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A Report On Health Care Access By The United States Citizens., Kelvin Njuki, Emil Agbemade Feb 2025

A Report On Health Care Access By The United States Citizens., Kelvin Njuki, Emil Agbemade

Data Science and Data Mining

Access to health care is a critical factor in ensuring public health. This study analyzes data from the National Health Interview Survey (NHIS) for the years 2015–2018 to examine the relationship between health care coverage, affordability, and costs among U.S. families. Re-sults indicate that families with at least one member covered by health insurance were more likely to afford medical care and incur lower health care costs. Despite a high proportion of families with health care coverage during this period, the number of insured family members declined over the years. These findings underscore the importance of health care coverage in …


Eng 3401-001 Methods Of Teaching Composition In The Middle And Secondary School, Elizabeth Tacke Feb 2025

Eng 3401-001 Methods Of Teaching Composition In The Middle And Secondary School, Elizabeth Tacke

Fall 2024

No abstract provided.


Cover And Contents Feb 2025

Cover And Contents

Turkish Journal of Chemistry

No abstract provided.


Triswinunetr Lobe Segmentation Model For Computing Dir-Free Ct-Ventilation, Gabriela Roque Oliveira Nomura, Aarom T. Luong, Ananya Prakash, Annabelle Alemand, Tanish Bhowmick, Alisa Ali, Jaimie Ren, Basil Rehani, Girish Nair, Richard Castillo, Yevgeniy Vinogradskiy, Edward Castillo Feb 2025

Triswinunetr Lobe Segmentation Model For Computing Dir-Free Ct-Ventilation, Gabriela Roque Oliveira Nomura, Aarom T. Luong, Ananya Prakash, Annabelle Alemand, Tanish Bhowmick, Alisa Ali, Jaimie Ren, Basil Rehani, Girish Nair, Richard Castillo, Yevgeniy Vinogradskiy, Edward Castillo

Department of Radiation Oncology Faculty Papers

Purpose: Functional radiotherapy avoids the delivery of high-radiation dosages to high-ventilated lung areas. Methods to determine CT-ventilation imaging (CTVI) typically rely on deformable image registration (DIR) to calculate volume changes within inhale/exhale CT image pairs. Since DIR is a non-trivial task that can bias CTVI, we hypothesize that lung volume changes needed to calculate CTVI can be computed from AI-driven lobe segmentations in inhale/exhale phases, without DIR. We utilize a novel lobe segmentation pipeline (TriSwinUNETR), and the resulting inhale/exhale lobe volumes are used to calculate CTVI. Methods: Our pipeline involves three SwinUNETR networks, each trained on 6,501 CT image pairs …


Elementary Italian Ii, Monica Rossi-Miller Feb 2025

Elementary Italian Ii, Monica Rossi-Miller

Open Educational Resources

Italian II aims at increasing the student's ability to use basic forms of oral communication in Italian through constant use of the everyday idiom. Carefully graded practice in reading and writing supplement the conversational aspects of the course. We will cover the second half of Italian Espresso 1 that is, chapter 7 through chapter 11, and the accompanying chapters in the workbook. We also will work on vocabulary, grammar, pronunciation, oral comprehension, conversation, spelling and writing. Speaking, oral comprehension, and conversation will be
emphasized.


Italian Culture Through Film, Monica Rossi-Miller Feb 2025

Italian Culture Through Film, Monica Rossi-Miller

Open Educational Resources

Introduction to important themes of Italian culture by viewing and analyzing
representative Italian films from the post-World War II era to the present. Topics examined include: the Italian family, how World War II has shaped contemporary Italian culture, Italy as a country of emigrants and immigrants, and an examination of religion and the Catholic Church.
This is a Writing Intensive course conducted in English, and all films have English subtitles.

A Writing Intensive Course Specifically is a designated course sections that—in addition to providing the established disciplinary-oriented student outcomes—incorporate approved instructional strategies and course assignments designed to enhance students’ writing …


Culture Of German Speaking Countries, Monica Rossi-Miller Feb 2025

Culture Of German Speaking Countries, Monica Rossi-Miller

Open Educational Resources

LG401 FNET is a 3 hours, 3 credits course with ENGL101 as a pre or co-requisite. It is an upper level course, however, no previous knowledge in Cultures of German speaking Countries is required, nor any knowledge of German language. The focus will be on cultures of countries in which German is an official language such as Germany, Austria, Switzerland and Liechtenstein. It fulfills 2A of the Common Core, WI (Writing intensive) requirement and Humanities elective.

Description: Students will be exposed to and discuss cultural developments in German-speaking countries including their role in the European Union. They will read …


Sidi Zin Archaeological Project: New Investigations Into The Acheulean And Middle Stone Age In Tunisia, Eslem Ben Arous, Nabiha Aouadi, Lotfi Belhouchet, Héla Mekki, Kaïs Trabelsi, Mosbah Mabrouki, El Mabrouk Essid, Noômène Fehri, Qingfeng Shao, Christophe Falguères, Vincent Lebreton, Patrick Roberts, Robert Patalano Feb 2025

Sidi Zin Archaeological Project: New Investigations Into The Acheulean And Middle Stone Age In Tunisia, Eslem Ben Arous, Nabiha Aouadi, Lotfi Belhouchet, Héla Mekki, Kaïs Trabelsi, Mosbah Mabrouki, El Mabrouk Essid, Noômène Fehri, Qingfeng Shao, Christophe Falguères, Vincent Lebreton, Patrick Roberts, Robert Patalano

Biological and Biomedical Sciences Department Faculty Journal Articles

The Sidi Zin Archaeological Project aims to bridge understanding of the Acheulean–Middle Stone Age transition in northern Tunisia, a relatively understudied region in the context of hominin evolution. The Sidi Zin locality will provide chronological, palaeoenvironmental, geomorphological and cultural insights into Acheulean and Middle Stone Age occupations in Tunisia.


Resilience, Joshua Liashenko Feb 2025

Resilience, Joshua Liashenko

Sociology Faculty Articles and Research

Once a ubiquitous framework for assessing the capacity for recovery, perseverance, and success in the face of adversity, resilience has been met with growing critiques in its application. As a frequently used “pretty word” within health disparities research, resilience has come to signify how at-risk communities overcome hardship in ways this work argues overdetermine their labor, activist potential, and existence. This critique examines resilience through the lens of ethnographic research conducted among transgender and nonbinary healthcare providers who provide gender-affirming care within their communities. As a marginalized community experiencing transphobia and increasing structural barriers to life-affirming and life-saving healthcare, trans …


David Garrison, Professor Emeritus, Department Of Modern Languages, College Of Liberal Arts, David Garrison, Kathy Morris Feb 2025

David Garrison, Professor Emeritus, Department Of Modern Languages, College Of Liberal Arts, David Garrison, Kathy Morris

Wright State University Retirees Association Oral History Project

In this February 17, 2025 oral history interview conducted by Kathy Morris, David Garrison reflects on his thirty-year career as Professor of Spanish and Portuguese at Wright State University. He discusses the growth of the Modern Languages Department, his service as chair, his work as a translator and interpreter in the Dayton community, and the practical value of language study.


A Narrative Policy Review Of Asthma Education Programs In North Carolina Schools, Rosemary Moody Feb 2025

A Narrative Policy Review Of Asthma Education Programs In North Carolina Schools, Rosemary Moody

Walden Dissertations and Doctoral Studies

Asthma remains one of the most common chronic conditions affecting school-aged children, posing significant challenges to their academic performance and overall well-being. However, the literature indicates that there continues to be barriers to successful implementation of asthma education policies in the public schools, particularly in the elementary levels. Using Maxwell’s interactive design for qualitative research, this study investigated how educators and stakeholders perceived the impact of state legislation on asthma education criteria and outcomes for student in grades K-5, as well as their recommendations for policy. Guided by Jones and McBeth’s narrative policy framework, semi structured interview data were collected …


Strategies For Improving Phlebotomy Training Programs In Midwestern Nonprofit Acute Care Hospitals, Zaid Naima Feb 2025

Strategies For Improving Phlebotomy Training Programs In Midwestern Nonprofit Acute Care Hospitals, Zaid Naima

Walden Dissertations and Doctoral Studies

Preanalytical errors in laboratory testing represent a significant challenge in healthcare delivery, accounting for most laboratory errors. Inadequate and inconsistent phlebotomy training has been identified as a major contributor to high rates of preanalytical errors and specimen rejection in nonprofit acute care hospitals within multihospital health systems in the U.S. Midwest region. The aim of this integrative review was to identify best practices and strategies for improving on-the-job phlebotomy training programs in Midwestern nonprofit acute care hospitals within multihospital health systems, using the Donabedian model as a framework to enhance specimen quality, reduce rejection rates, and increase patient satisfaction. A …


Health-Seeking Behaviors Of Asian American College Students With First-Generation Immigrant Parents, Andrea Michelle Ortega-Criddle Feb 2025

Health-Seeking Behaviors Of Asian American College Students With First-Generation Immigrant Parents, Andrea Michelle Ortega-Criddle

Doctor of Psychology (PsyD)

Asian Americans continue to underutilize mental health and health care services for various reasons such as cultural values, acculturation/enculturation, and lack of familiarity with the healthcare system (Ruzek et al., 2011). There is little information about how much influence first-generation Asian immigrant parents have on influencing health-seeking behaviors and attitudes of their Asian American children. While second-generation Asian Americans demonstrate adherence to both Asian and Western values, they continue to be less likely to seek health services than any other ethnic group in the United States. In order to provide more culturally aware and culturally sensitive services for Asian Americans, …


The Echo: February 17, 2025, Taylor University Feb 2025

The Echo: February 17, 2025, Taylor University

2024-2025 (Volume 112)

No abstract provided.


Is An Exclusive Pipeline Servitude Actually Exclusive? The Louisiana Second Circuit Opines, Ryan M. Seidemann Feb 2025

Is An Exclusive Pipeline Servitude Actually Exclusive? The Louisiana Second Circuit Opines, Ryan M. Seidemann

LSU Journal of Energy Law and Resources

No abstract provided.


Residence, Education, Wealth, And Hiv/Aids Prevention Knowledge Among Nigerian Adults, Chinedu Nwaobia Nwaru Feb 2025

Residence, Education, Wealth, And Hiv/Aids Prevention Knowledge Among Nigerian Adults, Chinedu Nwaobia Nwaru

Walden Dissertations and Doctoral Studies

HIV has remained the most prevalent and deadliest epidemic affecting humanity. It is pertinent to note that, despite the number of years since the first case was reported in the early 1980s in the United States, and concerted efforts by local, national, and international governmental and nongovernmental agencies at curbing it, the level of knowledge of HIV transmission and the disease prevention, especially among Nigerians, is still not encouraging. Nigeria, the most populous country in Sub-Saharan Africa ranks second globally as the country with the highest number of people living with HIV/AIDS, which is currently estimated at 3 million. In …


A Qualitative Exploration Of Urgent Care Clinic Providers’ Experiences With Patients With Mental Health Concerns, Teresa L. Hodges Feb 2025

A Qualitative Exploration Of Urgent Care Clinic Providers’ Experiences With Patients With Mental Health Concerns, Teresa L. Hodges

Walden Dissertations and Doctoral Studies

With mental health concerns on the rise in the United States and around the world, there has been a call for non-traditional avenues for the treatment of patients with mental health needs. Existing research indicates that in the current post-pandemic era, urgent care clinic providers have begun playing a pivotal role in the treatment of patients with mental health concerns. However, there is a lack of research currently available on the lived experiences of urgent care clinic providers treating of patients with mental health concerns. The purpose of this phenomenological study was to explore the lived experiences of urgent care …


Medical Laboratory Technologist Labor Market And Industry Initiatives To Address Labor Shortages, Jarvis John Surriga Feb 2025

Medical Laboratory Technologist Labor Market And Industry Initiatives To Address Labor Shortages, Jarvis John Surriga

Walden Dissertations and Doctoral Studies

The demand for laboratory testing has increased, requiring more medical laboratory technologists/scientists (MLTs/MLSs) in the United States. However, the supply of qualified MLS workers has decreased, which has caused a critical labor shortage. The purpose of this integrative review was to determine the best practices and strategies for improving the staffing and retention of clinical laboratory staff (CLS) given the growing demand for laboratory services. A search of empirical and nonempirical literature published between 2019 and 2024 yielded 1,935 articles, and exclusions resulted in 66 articles that addressed the problem. The additional examination resulted in 26 articles chosen for further …


The Rider (2025-02-17), Rebeca Salinas Feb 2025

The Rider (2025-02-17), Rebeca Salinas

The Rider Archives

Vol. 10, No. 19


Principal Perceptions Of Advising For The Adoption Of Social Media As An Instructional Application, Ben Hudson Feb 2025

Principal Perceptions Of Advising For The Adoption Of Social Media As An Instructional Application, Ben Hudson

Walden Dissertations and Doctoral Studies

Secondary school principals are seeking to meet students where they are by integrating social media into school curricula to enhance student learning. However, little has been published about principals’ perceptions of the value of social media as an instructional tool or the advising processes they employ to facilitate the adoption of social media as an instructional application. The problem this study addressed was principals’ perceptions of social media as an instructional application and how those perceptions influence decisions to advise for the adoption of social media for instructional purposes. Guided by Rogers’s diffusion of innovations theory and Davis’s technology acceptance …


Profile Analysis Of Handwashing Behavior Among A Sample Of College Students In The Multi-Theory Model Framework, Miguel Antonio Fudolig, Robert E. Davis, Kavita Batra, Manoj Sharma Feb 2025

Profile Analysis Of Handwashing Behavior Among A Sample Of College Students In The Multi-Theory Model Framework, Miguel Antonio Fudolig, Robert E. Davis, Kavita Batra, Manoj Sharma

Health, Human Performance and Recreation Faculty Publications and Presentations

Maintaining proper hand hygiene is crucial in preventing the spread of infections and other communicable diseases. It is imperative to determine the factors that affect the likelihood of initiating and maintaining the recommended handwashing behavior, especially during a pandemic. This quantitative, secondary study employed a latent profile analysis (LPA) to identify the different attitudes toward behavior change based on the Multi-Theory Model (MTM) framework in the context of following the guidelines provided by the Centers for Disease Control and Prevention (CDC) during the COVID-19 pandemic. Data were collected from 602 college students at a large university in the southern region …


Mitochondrial Dysfunction Is A Hallmark Of Woody Breast Myopathy In Broiler Chickens, Elizabeth S. Greene, Paula R. Chen, Carrie Walk, Mike Bedford, Sami Dridi Feb 2025

Mitochondrial Dysfunction Is A Hallmark Of Woody Breast Myopathy In Broiler Chickens, Elizabeth S. Greene, Paula R. Chen, Carrie Walk, Mike Bedford, Sami Dridi

Poultry Science Faculty Publications and Presentations

The woody breast (WB) myopathy poses significant economic and welfare concerns to the poultry industry, however, there is no effective strategy to mitigate this pathology due to its unknown etiology. After showing previously that hypoxia is a key factor in WB progression, we used here various techniques demonstrating dysregulated mitochondria (morphology, biogenesis, tethering, function, and bioenergetics) in WB-affected muscles and in hypoxic myoblasts compared to healthy tissues and normoxic cells, respectively. The increased levels of calcium (Ca2+) in both WB-affected tissues and hypoxic myoblasts suggested that mitochondrial Ca2+ overload is likely a leading cause for mitochondrial dysfunction that merits further …


The Role Of Urinary Microbiome Analysis In The Diagnostic Approach And Management Of Urinary Incontinence: A Systematic Review, Pouyan Shaker, Zohreh Roshani, Ehsan Timajchi, Zahra Sharifi, Sarah Nikzadfar Goli, Behrooz Broumand, Mohammad Ali Shafiee Feb 2025

The Role Of Urinary Microbiome Analysis In The Diagnostic Approach And Management Of Urinary Incontinence: A Systematic Review, Pouyan Shaker, Zohreh Roshani, Ehsan Timajchi, Zahra Sharifi, Sarah Nikzadfar Goli, Behrooz Broumand, Mohammad Ali Shafiee

Student Publications

Urinary incontinence (UI) is a significant global health issue that impacts mainly middle-aged women, severely affecting their quality of life. Emerging research highlights the urinary microbiome's complex role in the etiology and management of UI, with microbial dysbiosis potentially influencing symptom severity and treatment outcomes. This systematic review aimed to evaluate the current evidence on the urinary microbiome's role in diagnosing and managing UI, focusing on variations in microbial composition across UI subtypes. We identified 21 studies, mostly employing 16S rRNA sequencing to characterize urinary microbiota and their associations with various UI subtypes, including urgency urinary incontinence (UUI), overactive bladder …


Rna Methyltransferase Spout1/Cenp-32 Links Mitotic Spindle Organization With The Neurodevelopmental Disorder Spadmiss, Reza Maroofian, Tristan T Sands, Farid Ullah, Itaru Samejima, Yanwen Shen, Martin A Wear, Kiara E Moore, Elena Kondakova, Natalia Mitina, Theres Schaub, Grace K Lee, Christine H Umandap, Sara M Berger, Alejandro D Iglesias, Bernt Popp, Rami Abou Jamra, Heinz Gabriel, Stefan Rentas, Alyssa L Rippert, Christopher Gray, Kosuke Izumi, Laura K Conlin, Daniel C Koboldt, Theresa Mihalic Mosher, Scott E Hickey, Dara V F Albert, Haley Norwood, Amy Feldman Lewanda, Hongzheng Dai, Pengfei Liu, Tadahiro Mitani, Dana Marafi, Hatice Koçak Eker, Davut Pehlivan, Jennifer E Posey, Natalie C Lippa, Natalie Vena, Erin L Heinzen, David B Goldstein, Cyril Mignot, Jean-Madeleine De Sainte Agathe, Nouriya Abbas Al-Sannaa, Mina Zamani, Saeid Sadeghian, Reza Azizimalamiri, Tahere Seifia, Maha S Zaki, Ghada M H Abdel-Salam, Mohamed S Abdel-Hamid, Lama Alabdi, Fowzan Sami Alkuraya, Heba Dawoud, Aya Lofty, Peter Bauer, Giovanni Zifarelli, Erum Afzal, Faisal Zafar, Stephanie Efthymiou, Daniel Gossett, Meghan C Towne, Raey Yeneabat, Belen Perez-Duenas, Ana Cazurro-Gutierrez, Edgard Verdura, Veronica Cantarin-Extremera, Ana Do Vale Marques, Aleksandra Helwak, David Tollervey, Sandeep N Wontakal, Vimla S Aggarwal, Jill A Rosenfeld, Victor Tarabykin, Shinya Ohta, James R Lupski, Henry Houlden, William C Earnshaw, Erica E Davis, A Arockia Jeyaprakash, Jun Liao Feb 2025

Rna Methyltransferase Spout1/Cenp-32 Links Mitotic Spindle Organization With The Neurodevelopmental Disorder Spadmiss, Reza Maroofian, Tristan T Sands, Farid Ullah, Itaru Samejima, Yanwen Shen, Martin A Wear, Kiara E Moore, Elena Kondakova, Natalia Mitina, Theres Schaub, Grace K Lee, Christine H Umandap, Sara M Berger, Alejandro D Iglesias, Bernt Popp, Rami Abou Jamra, Heinz Gabriel, Stefan Rentas, Alyssa L Rippert, Christopher Gray, Kosuke Izumi, Laura K Conlin, Daniel C Koboldt, Theresa Mihalic Mosher, Scott E Hickey, Dara V F Albert, Haley Norwood, Amy Feldman Lewanda, Hongzheng Dai, Pengfei Liu, Tadahiro Mitani, Dana Marafi, Hatice Koçak Eker, Davut Pehlivan, Jennifer E Posey, Natalie C Lippa, Natalie Vena, Erin L Heinzen, David B Goldstein, Cyril Mignot, Jean-Madeleine De Sainte Agathe, Nouriya Abbas Al-Sannaa, Mina Zamani, Saeid Sadeghian, Reza Azizimalamiri, Tahere Seifia, Maha S Zaki, Ghada M H Abdel-Salam, Mohamed S Abdel-Hamid, Lama Alabdi, Fowzan Sami Alkuraya, Heba Dawoud, Aya Lofty, Peter Bauer, Giovanni Zifarelli, Erum Afzal, Faisal Zafar, Stephanie Efthymiou, Daniel Gossett, Meghan C Towne, Raey Yeneabat, Belen Perez-Duenas, Ana Cazurro-Gutierrez, Edgard Verdura, Veronica Cantarin-Extremera, Ana Do Vale Marques, Aleksandra Helwak, David Tollervey, Sandeep N Wontakal, Vimla S Aggarwal, Jill A Rosenfeld, Victor Tarabykin, Shinya Ohta, James R Lupski, Henry Houlden, William C Earnshaw, Erica E Davis, A Arockia Jeyaprakash, Jun Liao

Faculty, Staff and Students Publications

SPOUT1/CENP-32 encodes a putative SPOUT RNA methyltransferase previously identified as a mitotic chromosome associated protein. SPOUT1/CENP-32 depletion leads to centrosome detachment from the spindle poles and chromosome misalignment. Aided by gene matching platforms, here we identify 28 individuals with neurodevelopmental delays from 21 families with bi-allelic variants in SPOUT1/CENP-32 detected by exome/genome sequencing. Zebrafish spout1/cenp-32 mutants show reduction in larval head size with concomitant apoptosis likely associated with altered cell cycle progression. In vivo complementation assays in zebrafish indicate that SPOUT1/CENP-32 missense variants identified in humans are pathogenic. Crystal structure analysis of SPOUT1/CENP-32 reveals that most disease-associated missense variants are …


Markedly Elevated Blood Pressure, Tachycardia, And Altered Consciousness In Patients With Bacteremia During Transurethral Surgeries: Two Case Reports, Riko Uchida, Hiroshi Matsuura, Naoko Torii, Naoko Fujita, Taku Hamada, Ai Nakamoto, Noriko Yoshikawa Feb 2025

Markedly Elevated Blood Pressure, Tachycardia, And Altered Consciousness In Patients With Bacteremia During Transurethral Surgeries: Two Case Reports, Riko Uchida, Hiroshi Matsuura, Naoko Torii, Naoko Fujita, Taku Hamada, Ai Nakamoto, Noriko Yoshikawa

Faculty, Staff and Students Publications

Background: Transurethral surgery is often accompanied by postoperative urinary tract infection. Although early detection and adequate treatment of bacteremia are required to prevent sepsis, it is usually undetectable during surgery. We report two cases with remarkable hypertension and tachycardia during transurethral surgery in which bacteremia was diagnosed by an intraoperative blood test.

Case presentation: An 80-year-old man (Case 1) underwent transurethral holmium laser prostate enucleation under spinal anesthesia, and an 88-year-old woman (Case 2) underwent transurethral resection of bladder tumor under general anesthesia. Altered consciousness (Case 1) and postoperative delirium (Case 2) were noted, in addition to remarkable intraoperative hypertension …


The Unfolding Story Of Protein Misfolding Causing Alzheimer Disease In Recipients Of Human Pituitary Growth Hormone, Evan G. Graber, Sayed M. Hadi Hosseini, Darrell M. Wilson, Alan D. Rogol Feb 2025

The Unfolding Story Of Protein Misfolding Causing Alzheimer Disease In Recipients Of Human Pituitary Growth Hormone, Evan G. Graber, Sayed M. Hadi Hosseini, Darrell M. Wilson, Alan D. Rogol

Division of Endocrinology, Diabetes and Metabolic Diseases Faculty Papers

Human growth hormone (hGH) has been in clinical use for children with GH deficiency (GHD) since the late 1950s. The original formulations were considered very safe with few adverse events reported. That changed remarkably in 1985 when the first patients with GHD, who had been treated with cadaveric hGH, were diagnosed with Creutzfeldt-Jakob disease (CJD). Fortunately, that same year a robust supply of recombinant hGH was released to the market whose adverse event profile did not include CJD. Patients who had received National Hormone and Pituitary Program hGH have been continuously followed since 1985. It is clear that prions are …


Chimes: February 17, 2025, Calvin University Feb 2025

Chimes: February 17, 2025, Calvin University

Chimes

Confusion, apprehension run high among faculty as gravamen decision still up in the air by McKenna Wilkinson, Sarah Sparling & Ethan Meyers

Mayor David LaGrand, Calvin alum, shares his vision for Grand Rapids by McKenna Wilkinson & Sarah Sparling

The future and past of interdisciplinary minors by Elisabeth Stevens

Valentine's Week In A Nutshell by Natasha Jayaputra

"Team One": Women's acrobatics and tumbling makes history with first varsity match by Zach Kern

Late-Night concert sparks excitement for performing at Calvin by Stella Stachowiak


Ndls Communicator: Week Of 02.17.25, Notre Dame Law School Feb 2025

Ndls Communicator: Week Of 02.17.25, Notre Dame Law School

NDLS Communicator

The Latest News

  • ND Law Global Human Rights Clinic advocates for human rights before United States International Trade Commission
  • ND Law's Black Students Association celebrates Black History Month and the pursuit of justice
  • Professor Jorge Barrera-Rojas defends dissertation to earn two doctoral degrees
  • Notre Dame Law School's Religious Liberty Clinic secures asylum for Iranian Christian convert facing persecution

Faculty News and Briefs

  • Paul Miller was cited in an important dissenting opinion by Justices Gordon, Edelman, and Steward of the High Court of Australia for his work on fiduciary obligations.
  • This week, A.J. Bellia will speak on the legal implications of …


Next-Generation Sequencing-Based Msi Scoring Predicts Benefit In Mismatch Repair-Deficient Tumors Treated With Nivolumab: Follow-Up On Nci-Match Arm Z1d, Jonathan D Schoenfeld, Nilofer S Azad, Jacob Gross, Li Chen, Michael J Overman, Latifa Jackson, Xiangning Bu, Christina Coppola, Ping Guan, Jennifer Lee, David Sims, Rebecca Fuchs, Jason L Weirather, Kathleen L Pfaff, Lauren Gunasti, Srin Ranasinghe, Stanley R Hamilton, Victoria Wang, Peter J O'Dwyer, Catherine J Wu, Scott J Rodig, David R Patton, Lyndsay Harris Feb 2025

Next-Generation Sequencing-Based Msi Scoring Predicts Benefit In Mismatch Repair-Deficient Tumors Treated With Nivolumab: Follow-Up On Nci-Match Arm Z1d, Jonathan D Schoenfeld, Nilofer S Azad, Jacob Gross, Li Chen, Michael J Overman, Latifa Jackson, Xiangning Bu, Christina Coppola, Ping Guan, Jennifer Lee, David Sims, Rebecca Fuchs, Jason L Weirather, Kathleen L Pfaff, Lauren Gunasti, Srin Ranasinghe, Stanley R Hamilton, Victoria Wang, Peter J O'Dwyer, Catherine J Wu, Scott J Rodig, David R Patton, Lyndsay Harris

Faculty, Staff and Student Publications

Purpose: Mismatch repair-deficient (dMMR) tumors have demonstrated favorable responses to immune checkpoint inhibition targeting PD-1. However, more in-depth identification of predictors of response could further refine patient selection for immunotherapy treatment.

Patients and methods: We undertook integrated evaluation performed on samples collected from 28 of 42 patients enrolled on the NCI-Molecular Analysis for Therapy Choice arm Z1D trial that evaluated PD-1 inhibition treatment with nivolumab in patients with noncolorectal dMMR tumors. Genomic analyses were performed using next-generation sequencing (NGS), whole-exome sequencing, and RNA sequencing and supplemented by multiplex immunofluorescence performed on tissue samples.

Results: In this dMMR population, more extensive …


Techno-Economic Analysis For Floating Offshore Wind And Offshore Green Hydrogen, David Pegler, Deborah Greaves, Robert Rawlinson-Smith, Simone Michele, Daniel Conley, James Benhin Feb 2025

Techno-Economic Analysis For Floating Offshore Wind And Offshore Green Hydrogen, David Pegler, Deborah Greaves, Robert Rawlinson-Smith, Simone Michele, Daniel Conley, James Benhin

School of Engineering, Computing and Mathematics

This paper describes a techno-economic model for exploiting the Celtic Sea wind resource through direct productionof hydrogen offshore. The model conceives a modular approach with eight 510 MW floating windfarms,each with an electrolyser system and export compressor mounted on a jacket. The model ensures an uninterruptedhydrogen supply to an industrial cluster (16.4 te.H2/h) by incorporating salt cavern hydrogen storage.During periods of no power generation, baseload power is provided from hydrogen fuel cells. The base-casemodel with a Discount Rate of 6% returned an Levelised Cost of Hydrogen (LCoH) of £7.25 per kg of hydrogen in2023. The LCoH shows strong sensitivity to …