Digital Commons Network^™

Review Of Rejection: A Sumatran Odyssey, Kaisa R. Aquino

Perspectives in the Arts and Humanities Asia

No abstract provided.

Review Of Banaag At Sikat (Radiance And Sunrise), Christoffer Mitch C. Cerda

Perspectives in the Arts and Humanities Asia

No abstract provided.

Review Of “Homecoming And “Finale” By The Philippine Philharmonic Orchestra, Niccolo Rocamora Vitug

Perspectives in the Arts and Humanities Asia

No abstract provided.

The Columbus Promise: Year Two Evaluation Report, Michelle Miller-Adams, Kevin Hollenbeck, Bridget Timmeney, Kyle Huisman

Reports

No abstract provided.

Molecular Subtyping Of Hypertensive Disorders Of Pregnancy, Michal Elovitz, Elaine Gee, Nathaniel Delaney-Busch, Alison Moe, Mitsu Reddy, Arkady Khodursky, Johnny La, Ilma Abbas, Kay Mekaru, Hunter Collins, Farooq Siddiqui, Rory Nolan, Rupsa Boelig, Daniel Kiefer, Pamela Simmons, George Saade, Antonio Saad, Ebony Carter, Thomas Mcelrath, Stephen Quake, Mark Depristo, Carrie Haverty, Manfred Lee, Eugeni Namsaraev, Vincenzo Berghella, Ai-Ris Collier, Antonia Frolova, Esther Park-Hwang, Luis Pacheco, Elizabeth Sutton, Maneesh Jain, Kara Rood, William A Grobman, Joseph Biggio, Cynthia Gyamfi-Bannerman, Arun Jeyabalan, Morten Rasmussen

Department of Obstetrics and Gynecology Faculty Papers

Hypertensive disorders of pregnancy (HDP), including preeclampsia, affect 1 in 6 pregnancies, are major contributors to maternal morbidity and mortality, yet lack precision medicine strategies. Analyzing transcriptomic data from a prospectively-collected diverse cohort (n = 9102), this study reveals distinct RNA subtypes in maternal blood, reclassifying clinical HDP phenotypes like early/late-onset preeclampsia. The placental gene PAPPA2 strongly predicts the most severe forms of preeclampsia in individuals without pre-existing high risk factors, months before symptoms, and its overexpression correlates with earlier delivery in a dose-dependent manner. Further, molecular subtypes characterized by immune genes are upregulated in less severe forms of HDP. …

March Madness Plus, Richard C. Crepeau

On Sport and Society

March Madness, the NCAA marketing term, often is anything but. This year in both the women’s and men’s rendition, March Madness spilled over, as it often does into April. The final weekend, featuring the men’s and women’s semi-finals and finals, offered more madness than could have been hoped for.

Protecting Global Health Partnerships In The Era Of Destructive Nationalism, Maya Adam, Desiree Labeaud, Nokwanele Mbewu, Jennifer Gates, Randall Waechter, Mercy Borbor-Cordova, Lydiah Kibe, Sonia Alvarez, Annie Dori, Anil Bilimale, Meggie Mwoka, Jessica Deffler, Michele Spring, Avriel Diaz, Rachael Farquhar, Willy Dunbar, Comfort Phiri, Valerie Luzadis, Nicole Redvers, Cristina Alonso, Rosemary Rochford, Rachel Lowe, Kareem Coomansingh, Moses Laman, Rebeca Sultana, Sadie Ryan, Amaya Bustinduy, Anita Hargrave-Bouagnon, Shazia Ruybal-Pesántez, Zebedee Kerry, Trevor Kelebi, Samuel Mcewen, Leanne Robinson, Maritza Salazar Campo, Till Bärnighausen

Department of Family & Community Medicine Faculty Papers

No abstract provided.

The Cardiovascular Care Of The Pediatric Athlete, Peter N Dean, Julie A Brothers, Kristin Burns, Jonathan B Edelson, Susan Etheridge, Dermot M Phelan, Keri Shafer, Chris Snyder, Silvana Molossi, Alfred Danielian, Eli M Friedman, Jeff Hsu, Mustafa Husaini, Eugene H Chung, Matthew W Martinez, Aaron L Baggish, Benjamin D Levine, Jonathan H Kim, American College Of Cardiology Sports & Exercise Cardiology Council

Faculty, Staff and Students Publications

Sports cardiology broadly encompasses the cardiovascular care of individuals who place a high premium on habitual exercise, sports performance, and/or sports competition. Some of the essential aspects within sports cardiology include the preparticipation cardiac evaluation and the management of cardiac diseases in athletes. Although most sports cardiology practitioners are trained in adult cardiology, a significant number of individuals who participate in sports are pediatric-aged, < 18 years old. Up to two-thirds of children in middle and high school participate in organized sports or are involved in nonorganized recreational sports. The cardiovascular care of pediatric-aged athletes can be challenging because many of the classic tenets and principles in adult sports cardiology do not fully generalize to pediatrics, and there is a lack of the evidence base that may be present for adult athletes. The epidemiology, presentation, and progression of cardiovascular diseases can be significantly different between pediatric and adult athletes. The evaluation of potential diseases and management considerations may also differ between pediatric and adult athletes. Similar to adults, there are "gray zones" where it is difficult to differentiate between normal exercise-induced cardiac remodeling and true cardiac pathology, but the additional lack of normative standards further complicates assessments in pediatric athletes. Management decisions for pediatric athletes are generally based on limited data but carry substantial short- and long-term implications. Thus, shared decision-making as part of the determination of clinical management strategies and for sports participation is critical and requires the participation of the parents or guardian(s). In this state-of-the-art review, key differences between pediatric and adult-aged athletes are highlighted. Specifically, how to define the "pediatric athlete," consider cardiovascular adaptations observed among pediatric athletes, determine preparticipation screening options and optimal symptom-driven evaluations in children, and consider best practices for pediatric athletes with several key cardiac conditions are detailed. The purpose of this document is to represent the first primary reference available to providers who care for pediatric athletes with cardiovascular concerns.

The Challenges Facing Academic Freedom And Free Speech, Keith E. Whittington

Catholic University Law Review

There are growing challenges to free speech and academic freedom on American college campuses. There is pressure from both the political left and the political right to suppress controversial speech on campus, and there are calls to restrict speech that come both from members of the campus community and from those beyond the campus gates. In this difficult environment, it is essential that academics both understand the principles of academic freedom and campus free speech and work to advocate for them.

Emojis And Emoticons In U.S. Court Opinions, Eric Goldman

Historical and Topical Legal Documents

No abstract provided.

“I Never Wanted This”: Examining Maintenance Of White Femininity Within Abortion Stories On Tiktok, Brooke Pope

Communication ETDs

The invocation of tragedy in abortion stories has been acknowledged as a rhetorical tool that creates affective prescriptions and marginalization. Expanding on this concept, this work identifies how these strategies are used to maintain white femininity structurally through individual narratives. An intersectional feminist rhetorical analysis of abortion stories told on the platform TikTok is used to identify discursive practices that signal to white femininity. These practices are organized into three prominent themes within narratives: moves toward victimization, moves toward innocence, and prescribed punishments. Thematically, these serve to identify how pro-choice rhetoric fails to be intersectional and underscore the importance of …

The Unconstitutional Impact Of Anti-Transgender Legislation On Native Hawaiians, Aaliah Moi-Matsumoto

Seattle Journal for Social Justice

No abstract provided.

The Art Of Craft: An Inquiry Into The Illusion Of Difference, Abigail Cancel

Honors Theses

The art of craft: an inquiry into the illusion of difference is an exploration of why art and craft have been historically separated and the ways in which this idea pervades into the modern world. It touches on the importance of art to society overall, as well as the undeniable significance of craft to the art world.

3d-Printed Organ-Realistic Phantoms To Verify Quantitative Spect/Ct Accuracy For 177lu-Psma-617 Treatment Planning, Lydia J. Wilson, Sara Belko, Eric L. Gingold, Shuying Wan, Rachel Monane, Robert S. Pugliese, Firas Mourtada

Department of Radiation Oncology Faculty Papers

Background/Objectives: Accurate patient-specific dosimetry is essential for optimizing radiopharmaceutical therapy (RPT), but current tools lack validation in clinically realistic conditions. This work aimed to develop a workflow for designing and fabricating patient-derived, organ-realistic RPT phantoms and evaluate their feasibility for commissioning patient-specific RPT radioactivity quantification. Methods: We used computed tomographic (CT) and magnetic resonance (MR) imaging of representative patients, computer-aided design, and in-house 3D printing technology to design and fabricate anthropomorphic kidney and parotid phantoms with realistic organ spacing, anatomically correct orientation, and surrounding tissue heterogeneities. We evaluated the fabrication process via geometric verification (i.e., volume comparisons) and leak testing …

Leveraging Llms To Understand Narratives In Maude Reports, Yuheng Shi, Yang Gong

Faculty, Staff and Student Publications

Interest in using the MAUDE database to investigate adverse events linked to medical devices has been growing. Yet, the narrative sections of these reports remain largely unexplored, leaving valuable insights unutilized and creating an incomplete understanding of these events. To bridge this gap, we employ large language models (LLMs) to analyze and interpret these narratives. Using OpenAI's GPT-4-turbo model, we focused on MAUDE reports involving endoscopic clips to identify uncoded surgical procedures and uncover additional insights. This approach showcases the potential of LLMs in processing narrative content, offering a more efficient and cost-effective alternative to previous methods and supporting the …

Gpat4 Sustains Endoplasmic Reticulum Homeostasis In Endocardial Cells And Safeguards Heart Development, Tianyang Zhao, Kuipei Jin, Xiaodong Wang, Xiong Su, Youjun Wang, Mingming Gao, Wen Luo, Hongyuan Yang, Zhongzhou Yang

Faculty, Staff and Student Publications

The endocardium plays a pivotal role in governing myocardial development, and understanding the intrinsic regulatory insights will help apprehend pathological cardiomyopathy. Glycerol-3-phosphate acyltransferase 4 (GPAT4) is an endoplasmic reticulum (ER) membrane anchored protein. While the role of GPAT4 in glycerophospholipid biosynthesis is well established, its function in the ER is less explored. Here, we generate Gpat4 global and tissue-specific knockout mice and identify the essential role of GPAT4 in endocardial development. Deficiency of GPAT4 provokes endocardial ER stress response and enhances ER-mitochondrial (ER-mito) communications, leading to mitochondrial DNA (mtDNA) escape. As a result, the cGAS-STING pathway is triggered to stimulate …

A Fig Is More Than The Sum Of Its Seeds, Yana Giannoutsos

Montserrat Annual Writing Prize

This personal creative nonfiction essay, inspired by Aimee Nezhukumatathil’s nature writing, reflects on my evolving relationship with my Greek grandmother through the enduring symbol of the fig tree and its "roots". Blending memory, cultural heritage, and sensory detail, the piece explores the fig tree as a symbol of resilience, continuity, and the unspoken traditions passed down across generations.

Tacting The Functions Of Behavior And College Mental Health: A Mobile App-Based Approach To Developing Psychological Flexibility, Benjamin G. Pierce, Michael P. Twohig, Michael E. Levin

Psychology Faculty Publications

This study evaluated a brief Acceptance and Commitment Therapy (ACT) Matrix app to improve college student mental health in a randomized waitlist-controlled trial. It was hypothesized that participants assigned to the ACT Matrix app would report greater improvements than the waitlist condition on measures of psychological inflexibility (e.g., Acceptance and Action Questionnaire-II; Tacting of Function [TOF] scale), distress (e.g., Patient Health Questionnaire), and functioning (e.g., Satisfaction with Life Scale) as well as that changes in psychological inflexibility variables would predict improvements in distress and functioning at post-intervention and 4-week follow up. The sample included 106 students reporting elevated depression or …

Open Accessarticle Crystal Plasticity Modeling Of Dislocation Density Evolution In Cellular Dislocation Structures, Md Mahabubur Rohoman, Caizhi Zhou

Faculty Publications

The complex thermal cycles during the solidification process in metal additive manufacturing (AM) lead to the formation of high-density dislocation networks, organizing into submicron-scale cellular structures. These ultrafine structures are recognized as crucial for enhancing the mechanical properties of AM metals. In this study, we investigate the evolution of dislocation density within these cellular structures under plastic deformation and its impact on mechanical response using dislocation density-based crystal plasticity finite element (CPFE) modeling. The model incorporates the evolution of both statistically stored dislocation (SSD) and geometrically necessary dislocation (GND). Our simulations reveal that the yield and flow stresses of dislocation …

Deep Jansen-Rit Parameter Inference For Model-Driven Analysis Of Brain Activity, Deepa Tilwani, Christian O'Reilly

Faculty Publications

Accurately modeling effective connectivity (EC) is critical for understanding how the brain processes and integrates sensory information. Yet, it remains a formidable challenge due to complex neural dynamics and noisy measurements such as those obtained from the electroencephalogram (EEG). Model-driven EC infers local (within a brain region) and global (between brain regions) EC parameters by fitting a generative model of neural activity onto experimental data. This approach offers a promising route for various applications, including investigating neurodevel- opmental disorders. However, current approaches fail to scale to whole-brain analyses and are highly noise-sensitive. In this work, we employ three deep-learning architectures—a …

The Curse Of El Dorado: How The Californnia Gold Rush Shaped The History Of Hawai'i, Ernesto Coronado

Theses and Dissertations

In the discourse of Western historiography, we fail to account for the importance of the Hawai’ian Islands. American imperialism did not stop with the occupation of the Pacific Coast but continued into the Pacific. In the mid-nineteenth century, Hawai’i and its monarch, King Kamehameha III, stood at the center of a dispute between Britain, France, and the United States. King Kamehameha III used the California Gold Rush and Hawai’i’s location to his advantage to garner capital and prevent the imperial powers from annexing his kingdom. However, even he knew he could not stop the mass wave of Hawai’ians leaving the …

Tumor-Derived Arachidonic Acid Reprograms Neutrophils To Promote Immune Suppression And Therapy Resistance In Triple-Negative Breast Cancer, Liqun Yu, Keziah Liebenberg, Yichao Shen, Fengshuo Liu, Zhan Xu, Xiaoxin Hao, Ling Wu, Weijie Zhang, Hilda L Chan, Bo Wei, Philip L Lorenzi, Yang Gao, Igor Bado, Luis Becerra-Dominguez, Charlotte Helena Rivas, Sergio Aguirre, Bradley C Pingel, Yi-Hsuan Wu, Yunfeng Ding, Jun Liu, David G Edwards, Livia S Eberlin, Xiang H-F Zhang

Faculty, Staff and Students Publications

The combination of immune checkpoint blockade and chemotherapies is the standard of care for triple-negative breast cancer (TNBC). However, initially, responsive tumors can still develop recurrences, suggesting acquired resistance mechanisms that remain poorly understood. Herein, we discover that TNBC cells surviving anti-programmed cell death protein-1 (anti-PD-1) and chemotherapy treatment accumulate neutral lipids. Disrupting lipid droplet formation in cancer cells reverses resistance and mitigates the immunosuppressive microenvironment. Single-cell RNA sequencing reveals a subset of neutrophils exhibiting a lipid-laden phenotype similar to adjacent tumor cells. Mechanistically, tumor-derived extracellular vesicles carrying lipids, including arachidonic acid (AA), mediate neutrophil reprogramming. Blocking dietary intake of …

Differential Antibody Response To Ebv Proteome Following Ebvst Immunotherapy In Ebv-Associated Lymphomas, Yomani D Sarathkumara, Nathan W Van Bibber, Zhiwei Liu, Helen E Heslop, Rayne H Rouce, Anna E Coghill, Cliona M Rooney, Carla Proietti, Denise L Doolan

Faculty, Staff and Students Publications

Epstein-Barr virus (EBV) is associated with a diverse range of lymphomas. EBV-specific T-cell (EBVST) infusions have shown promise in safety and clinical effectiveness in treating EBV-associated lymphomas; however, not all patients respond to T-cell immunotherapies. To identify EBV antigen–specific antibody responses associated with clinical outcomes, we comprehensively characterized antibody responses to the complete EBV proteome using a custom protein microarray in 56 patients with EBV-associated lymphoma who received EBVST infusions in phase 1 clinical trials. Responders (nonprogressors) and nonresponders (progressors) had distinct antibody profiles against EBV. Twenty-five immunoglobulin G (IgG) antibodies were significantly elevated in higher levels in nonresponders than …

Detection Of Co2 Locally Generated By Formate Dehydrogenase Using Carbonate Ion-Selective Micropipette Electrodes, Seol Baek, Salvador Gutierrez-Portocarrero, Rokas Gerulskis, Shelley D. Minteer, Sean R. German, Henry S. White

Chemistry Faculty Research & Creative Works

Many technologies involve immobilizing catalysts such as enzymes on surfaces, and the catalytic activities or functional efficiencies of these surface-bound catalysts can vary depending on orientations, localized binding sites, active sites, and intrinsic molecular nature. Accurate and rapid quantification of reaction products from surface-immobilized catalysts is crucial for understanding the selectivity, mechanisms, and reaction dynamics of catalytic systems and for revealing heterogeneous catalytic activities and reaction sites for applications such as biosensors and energy conversion/generation systems. Here, we demonstrate the feasibility of localized enzymatic activity measurements using microscale carbon dioxide (CO₂)-sensitive ion-selective electrode (ISE) pipettes (0.5-2.5 μm tip …

Challenges In Transitioning From Methadone To Buprenorphine-Naloxone For Chronic Pain Management: Two Cases, Jamal Hasoon, Anvinh Nguyen, Omar Viswanath, Alaa Abd-Elsayed

Faculty, Staff and Students Publications

Background: Methadone is frequently used for chronic pain management due to its long half-life and NMDA receptor activity, making it an effective option for opioid-tolerant patients. Buprenorphine-naloxone is increasingly explored as an alternative for chronic pain and opioid use disorder, offering partial opioid agonism with a ceiling effect on respiratory depression. The transition from methadone to buprenorphine-naloxone remains clinically challenging, requiring careful management to prevent withdrawal and ensure adequate pain control.

Case descriptions: Two patients with chronic pain were transitioned from methadone to buprenorphine-naloxone. The first patient, a mid-40s female, was abruptly switched from methadone 10 mg twice daily dosing …

84 - Effect Of Organized Sport Interventions On Motor Outcomes Of Children With Autism Spectrum Disorder - A Systematic Review., Maeren Hill, Kailash Ram, Caitlyn Warnock, Kaitlin Hardy, Sonia Khurana, Pt, Ph.D.

Undergraduate Research Symposium

Aim:

The aim of this systematic review was to synthesize randomized clinical trials to evaluate the effectiveness of sports-based interventions on motor outcomes in children with autism spectrum disorder (ASD).

Methods:

A comprehensive literature search was conducted on the following five databases from inception to November 2024: PubMed, Web of Science, CINAHL, Cochrane Library, and Clinical Trials. Gray literature was sourced from Google Scholar and ProQuest Dissertations and Theses.

Articles were eligible for inclusion if they met the following criteria: (1) published in English; (2) participants were under the age of 18 with a diagnosis of ASD; (3) interventions consisted …

70 - Unmeasured Confounding In Meta-Analyses Of Observational Studies Evaluating Maternal Periodontitis And Adverse Birth Outcomes, May Salama, Abdullah Al-Taiar, Denise Claiborne, Anwar Merchant

Undergraduate Research Symposium

Background: Maternal periodontitis has been consistently linked to adverse birth outcomes (ABOs). However, a causal relationship is not established due to potential unmeasured confounding factors in observational studies and inconclusive results from randomized controlled trials. This study aimed to assess the impact of unmeasured confounding factors in meta-analyses examining associations between maternal periodontitis and preterm birth (PTB) or low birth weight (LBW).

Methods: PubMed and MEDLINE, Cochrane, Embase, and Google Scholar were searched for systematic reviews with meta-analyses of observational studies between 2002 and 2023. Systematic reviews with meta-analyses of observational studies were included if either PTB or LBW were …

The Role Of Capital On Literacy And Second Language Acquisition: A Cross-National Comparative Study, Brenda Koumondji

INSPIRE Student Research and Engagement Conference

Key Context:

• Globalization has increased the demand for multilingual skills.
• Yet, language learning opportunities vary based on national education policies and socioeconomic factors.
• Language learning opportunities are shaped by social structures and vary based on economic,social, and cultural capital (ESC) (Bourdieu, 1986).

Second Language Benefits

• Economic (Brown & Lauder, 1991; Foreman-Peck & Wang, 2014)
• Cognitive and Psychological (Bialystok, 2011; Dewaele & Wei, 2012; Graham, 2017)
• Social and Cultural (Marboua et al., 2024)

Research Focus:

• Cross-national comparison of South Korea, Norway, Chile, and the U.S.

A Systematic Review Of Cultural And Structural Barriers To Mammogram Access Among Immigrant Women, Abeer Wael Abukamil, Samar Ghassan Chehab, Sabrina Khan, Rima Charara

Medical Student Research Symposium

Introduction:

Mammograms are crucial for early breast cancer detection and reducing mortality (5). However, U.S. minorities, particularly immigrants, are less likely to receive screenings (9). Identifying barriers can help tailor interventions to meet immigrant women’s needs.

Methods:

Studies were found on PubMed using a systematic review protocol following PRISMA guidelines (8). Search terms included “minority,” “mammograms,” and “barriers.” Articles were then selected for a full-text review by three authors. 220 articles were narrowed down to 7 by relevance and date of publishing (2005 and beyond).

Results:

Cultural barriers often limit immigrant women’s access to breast cancer screenings. In certain non-Western …

The Influence Of Field Experiences On English Language Teachers' Preparedness: An Analysis Of Teacher Education In Nigeria, Bushroh O. Animashaun

INSPIRE Student Research and Engagement Conference

Brief Context:

• Definition of key terms: teacher education, field experiences.
• Importance of teacher education in language education
• Challenges in the Nigerian education system
• Why focus on teacher education?