Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 51961 - 51990 of 1440097

Full-Text Articles in Entire DC Network

Inspire Student Research & Engagement Conference [Program] April 7-8, 2025, University Of Northern Iowa Apr 2025

Inspire Student Research & Engagement Conference [Program] April 7-8, 2025, University Of Northern Iowa

INSPIRE Student Research & Engagement Conference Programs

A program for the INSPIRE conference where undergraduate and graduate students present their research, internship, volunteer and study abroad experiences, club activities and creative performances.


A Pilot Study On Tailored Dynamic Written Corrective Feedback For High School Chinese Language Learners, Cilei Han Apr 2025

A Pilot Study On Tailored Dynamic Written Corrective Feedback For High School Chinese Language Learners, Cilei Han

Doctor of Education (EdD)

Despite a significant increase in global efforts to teach and learn Chinese as a foreign language (CFL) in recent decades (Center for Applied Second Language Studies, 2010), past research reveals that CFL learners face greater challenges in writing than their peers studying AP1 Spanish, French, and German, underscoring the need for targeted writing support at the high school intermediate level (College Board, 2025). To address the gap, this mixed-methods study tailored Dynamic Written Corrective Feedback (DWCF), originally designed for college English (as a second language, ESL) writing courses, to high school intermediate CFL learners. Participants included Level IV students (n …


Dollars And Zen: A Randomized Control Trial Of A Community-Partnered Financial Capability And Stress Management Digital Intervention Among Low-Income Latino Adults, Luisa Blanco, Nataria Joseph, Mckenzie Richards, Flora Sedrakyan Apr 2025

Dollars And Zen: A Randomized Control Trial Of A Community-Partnered Financial Capability And Stress Management Digital Intervention Among Low-Income Latino Adults, Luisa Blanco, Nataria Joseph, Mckenzie Richards, Flora Sedrakyan

School of Public Policy Working Papers

Latino adults disproportionately experience financial stress, but no programs developed for Latinos comprehensively and successfully integrate financial capability and stress management approaches to address financial stress. Using a community-partnered approach, we enhanced a digital financial capability intervention with theoretically- and empirically-grounded stress management techniques. We tested whether this integrative intervention improved financial capability, self-efficacy, actions, and stress as well as sleep, a correlate of stress. A sample of 76 Latino adults (39 in the intervention group, 37 in the control group; mean age = 45, 76% female, 88% with household income below $59,999) completed the three-month randomized waitlist-control trial. Participants …


Short-Term Study Abroad Programs: A Sustainable Model For Community Colleges, Jorge Grajales-Díaz Apr 2025

Short-Term Study Abroad Programs: A Sustainable Model For Community Colleges, Jorge Grajales-Díaz

Inquiry: The Journal of the Virginia Community Colleges

This study employed qualitative methods to explore how the UVA in Valencia Summer Program 2019/ 2021 approached instructional practices (e.g., in-class and out-of-class immersive learning activities, homestays, pre-program services, including use of L2 and culture learning strategies) to identify those features of the program design that Piedmont Virginia Community College (PVCC) could reproduce in a new short-term study abroad designed to expand its students’ oral proficiency and cultural awareness. The study used data from Zoom interviews with faculty, administrators, and L2 participating students. The findings address the study’s purpose in describing how the UVA in Valencia Summer Program 2019/ 2021 …


Ai Beliefs And Practices In Community College Classrooms, Julie Eng, Heather Umphlett, Jocelyn Gilchrist, Alicia Howell, Mary Ann Howell, Wendy Miller-Edwards, Laurel Pope Apr 2025

Ai Beliefs And Practices In Community College Classrooms, Julie Eng, Heather Umphlett, Jocelyn Gilchrist, Alicia Howell, Mary Ann Howell, Wendy Miller-Edwards, Laurel Pope

Inquiry: The Journal of the Virginia Community Colleges

The country, the Commonwealth of Virginia, and Virginia Community College System initiatives all promote generative AI within education. It is a topic of great concern and interest for higher education instructors, yet at the same time many faculty members feel uncertain about effectively integrating it into class material. To further add pressure to the AI explosion, community colleges particularly face a responsibility to prepare their students for success in this new AI-focused environment. In this article, seven faculty members from Camp Community College discuss the implications of generative AI programs, including subscriptions and chatbots, within their particular courses and how …


The Impact Of Dual Enrollment On Educational Aspirations Of Traditionally Underrepresented Students In Community College, Wayne Carter, Carol Gruber Apr 2025

The Impact Of Dual Enrollment On Educational Aspirations Of Traditionally Underrepresented Students In Community College, Wayne Carter, Carol Gruber

Inquiry: The Journal of the Virginia Community Colleges

This research study examined the difference in academic motivation and academic self-efficacy of traditionally underrepresented students in community college who previously participated in high school dual enrollment programs versus their comparable peers without dual enrollment experience. This is important given the socio-economic disparities between the various student groups participating in this selective college preparatory program. Historically, traditionally underrepresented students have yet to participate in dual enrollment programs commensurate with their non-minority and affluent peers. By examining the difference between these two specific student subgroups, the researchers addressed what types of motivation and self-efficacious behaviors affected these college students who opted …


Ai Isn’T What We Should Be Worried About – It’S The Humans Controlling It, Billy J. Stratton Apr 2025

Ai Isn’T What We Should Be Worried About – It’S The Humans Controlling It, Billy J. Stratton

English and Literary Arts: Faculty Scholarship

Stratton examines depictions of AI in popular media and literature, drawing comparisons to real-world AI and humanity's capacity to harness technology for good or ill.


Exploring Credit Loss For Engineering Transfer Students, Amy J. Richardson, David B. Knight Apr 2025

Exploring Credit Loss For Engineering Transfer Students, Amy J. Richardson, David B. Knight

Inquiry: The Journal of the Virginia Community Colleges

One of the issues at the heart of transfer is the mobility of credits across institutions—moving credits from one institution to another is a crucial process for the transfer pathway to be a viable option. Credit loss is a critical issue for transfer students enrolled in highly sequential degrees, such as engineering. A student could be set back a year or more if they miss one required prerequisite course at the time of transfer. Determining who experiences credit loss in engineering could help ease the transfer process, improve graduation rates, and broaden participation in engineering since the transfer pathway has …


Characterizing Stroke Presenting To A Regional Referral Hospital Before And During The Covid-19 Pandemic In Uganda: A Retrospective Analysis, Christopher Burant, Shirley Moore, Martha Sajatovic Apr 2025

Characterizing Stroke Presenting To A Regional Referral Hospital Before And During The Covid-19 Pandemic In Uganda: A Retrospective Analysis, Christopher Burant, Shirley Moore, Martha Sajatovic

Faculty Scholarship

Introduction: Stroke, a leading cause of global morbidity and mortality, disproportionately impacts low and middle-income countries, particularly in sub-Saharan Africa (SSA) which reports the highest stroke burden. The COVID-19 pandemic further complicated this situation, emerging as a significant stroke risk factor. The pandemic also disrupted healthcare systems worldwide, affecting stroke management and care accessibility, and leading to deteriorated conditions in stroke patients upon hospital admission. In this pre/during COVID-19 pandemic analysis of acute stroke cases presenting to a Ugandan hospital, we investigated the relationship between stroke admissions, management and treatment outcomes. Methods: This was a retrospective medical record review in …


Gardner-Webb Team Answers Call To Help Neighbors In Western North Carolina, Office Of University Communications Apr 2025

Gardner-Webb Team Answers Call To Help Neighbors In Western North Carolina, Office Of University Communications

Gardner-Webb NewsCenter Archive

Over the years, the Gardner-Webb Office of Christian Life and Service has led student mission teams to serve around the world and other parts of the United States. This year, some of the greatest needs were close to home, just over an hour from campus.


Rotunda - Vol 104, No 6 - Apr 7, 2025, Longwood University Apr 2025

Rotunda - Vol 104, No 6 - Apr 7, 2025, Longwood University

Rotunda

No abstract provided.


Daily Acute Intermittent Hypoxia Elicits Age & Sex-Dependent Changes In Molecules Regulating Phrenic Motor Plasticity, Jayakrishnan Nair, Alexandria Marciante, Carter Lurk, Mia Kelly, Maclain Capron, Gordon Mitchell Apr 2025

Daily Acute Intermittent Hypoxia Elicits Age & Sex-Dependent Changes In Molecules Regulating Phrenic Motor Plasticity, Jayakrishnan Nair, Alexandria Marciante, Carter Lurk, Mia Kelly, Maclain Capron, Gordon Mitchell

Department of Physical Therapy Faculty Papers

Acute intermittent hypoxia (AIH) elicits a form of respiratory motor plasticity known as phrenic long-term facilitation (pLTF). Exposure to repetitive daily AIH (dAIH) enhances pLTF, a form of metaplasticity. Little is known concerning cellular mechanisms giving rise to dAIH-induced metaplasticity and the age-dependent sexual dimorphism of AIH associated pro-plasticity mRNA expression. To test if age, sex, and dAIH effects are associated with differential expression of molecules that regulate the Q- and S-pathways and their cross-talk interactions to phrenic motor facilitation, we analyzed key regulatory molecules in ventral spinal (C3-C5) homogenates from young (3-month) and middle-aged (12-month) male and female Sprague-Dawley …


A Multimethod Study Of The Impact Of Nudge Letters On Middle School Students’ Attendance, Kaila M. Wilson Apr 2025

A Multimethod Study Of The Impact Of Nudge Letters On Middle School Students’ Attendance, Kaila M. Wilson

Doctor of Education (EdD)

The purpose of this study was to increase parent involvement by using nudge theory to increase students’ overall attendance. This study addressed the issue of chronic absenteeism in K–12 schools in the current landscape of post-COVID-19 global pandemic where absenteeism has remained a persistent problem in Oregon. Chronic absenteeism affects student academics, behavior, and socioemotional well-being, displaying the importance of schools increasing their communication efforts with families. Attendance interventions have been used, but chronic absenteeism has remained at high levels postpandemic. Using nudge letters as an intervention is limited yet has proven to be effective in some schools in the …


Evaluating The Performance Of Bayesian Removal Models For Estimating Population Density And Detecting Trends With Variable Detection Probability, David R. Stewart Apr 2025

Evaluating The Performance Of Bayesian Removal Models For Estimating Population Density And Detecting Trends With Variable Detection Probability, David R. Stewart

Mathematics & Statistics ETDs

Removal models have long been used to estimate population abundance by progressively capturing and removing individuals from a closed population. These models provide a valuable tool for ecological monitoring, but their accuracy depends heavily on assumptions about detection probability, which may decline over successive sampling passes. Traditional removal models assume constant detection probabilities, an assumption that is often violated in real-world applications. This thesis aims to advance hierarchical Bayesian models by accounting for variable detection probabilities, improving the reliability of abundance estimates and trend detection. By integrating simulation-based analyses with empirical data from Lahontan Cutthroat Trout (Oncorhynchus clarkia henshawi …


Pediatric And Congenital Cardiac Services: An Innovative And Empowering Approach To Global Training And Equitable Care, Wyman W. Lai, Dominique Vervoort, David Bradley, Antonio G. Cabrera, Casey Culbertson, Alejandro Floh, Saurabh K. Gupta, Babar S. Hasan, Adrian Holloway, Jeffrey P. Jacobs, Kathy J. Jenkins, R. K. Kumar, L.A. Larrazabal, Colin J. Mcmahon, Daniel J. Penny, Alistair Phillips, Emilio Quezada, Craig A. Sable, Shubhika Srivastava, Sandra L. Staveski, Patcharapong Suntharos, David F. Teitel, Betsy Tirado, Brian C. Tran, Bistra Zheleva, Liesl Zuhkle, Anthony C. Chang Apr 2025

Pediatric And Congenital Cardiac Services: An Innovative And Empowering Approach To Global Training And Equitable Care, Wyman W. Lai, Dominique Vervoort, David Bradley, Antonio G. Cabrera, Casey Culbertson, Alejandro Floh, Saurabh K. Gupta, Babar S. Hasan, Adrian Holloway, Jeffrey P. Jacobs, Kathy J. Jenkins, R. K. Kumar, L.A. Larrazabal, Colin J. Mcmahon, Daniel J. Penny, Alistair Phillips, Emilio Quezada, Craig A. Sable, Shubhika Srivastava, Sandra L. Staveski, Patcharapong Suntharos, David F. Teitel, Betsy Tirado, Brian C. Tran, Bistra Zheleva, Liesl Zuhkle, Anthony C. Chang

Division of Cardiology Faculty Papers

Congenital heart disease is a leading cause of preventable death in children, with a disproportionate impact on low- and middle-income countries. Despite progress in treating congenital heart disease globally, significant challenges remain in accessing specialized cardiovascular care, particularly cardiac surgery, in low- and middle-income countries. This review examines current models of assistance and proposes a novel global training program to address these inequities. Key challenges identified include building program infrastructure, training health care providers, ensuring financial sustainability, and promoting local engagement. The proposed program, structured under a new international organization, will leverage emerging technologies to deliver accessible and rigorously assessed …


Achieving Periodontal Disease Stabilization: Assessing The Impact Of Laser Therapy In Scaling And Root Planing And Periodontal Maintenance Visits, Cassandra Charlotte Cooper Apr 2025

Achieving Periodontal Disease Stabilization: Assessing The Impact Of Laser Therapy In Scaling And Root Planing And Periodontal Maintenance Visits, Cassandra Charlotte Cooper

Dental Hygiene ETDs

Purpose: This study examined the effectiveness of laser utilization in stabilizing periodontal disease over a one-year period. This research focused on the results following scaling and root planing with adjunctive laser-assisted periodontal therapy and laser bacterial reduction at subsequent periodontal maintenance visits. While short-term advantages are documented in the literature, research on sustained effectiveness is limited. Methods: A retrospective chart review of 30 adult patients who received the above treatment was conducted. Periodontal charting was recorded at three visits over one year. Data was collected and analyzed utilizing Statistical Package for Social Sciences (SPSS) to determine statistical significance of periodontal …


The Role Of The Church In The German Democratic Republic: Examining The Representation Of Christianity In The Novel Einer Trage Des Anderen Last Within Its Cultural And Historical Context, Arden Remnant Gewirtz Levine Apr 2025

The Role Of The Church In The German Democratic Republic: Examining The Representation Of Christianity In The Novel Einer Trage Des Anderen Last Within Its Cultural And Historical Context, Arden Remnant Gewirtz Levine

Foreign Languages & Literatures ETDs

The attitude towards the Protestant Church in the German Democratic Republic (GDR) changed overtime and was not homogenous during the approximately forty years of the GDR’s existence. This thesis will use this established cultural and historical context in order to analyze the representation of Christianity in the novel Einer trage des anderen Last, written by Wolfgang Held. The premise of the novel is two men diagnosed with tuberculosis are forced to share a room in the Sanatorium, however, one is a protestant pastor and the other is a member of the Volkspolizei (the People’s police). Through their distinct ideologies …


The Impact Of Perceived Discrimination On Mental And Physical Health Among The Hispanic Immigrant Population, Cheyla Tabares Cuesta Apr 2025

The Impact Of Perceived Discrimination On Mental And Physical Health Among The Hispanic Immigrant Population, Cheyla Tabares Cuesta

Undergraduate Theses

Discrimination has profoundly shaped the lives of individuals within disadvantaged communities, but its impact on mental and physical health has often been overlooked. In this project, I review literature on perceived discrimination based on immigrant status and its effects on psychological and physical health and examine a potential mediator and moderator of these relationships. Specifically, the relationships between immigration-based discrimination and both mental health and physical health may be mediated by perceived stress, meaning that discrimination may lead to higher stress levels, which results in poorer health outcomes. Furthermore, these relationships may be moderated by psychological resilience; individuals with higher …


Ototoxicity Monitoring: The Evolution Of A Protocol For Head And Neck Cancer Patients, Jena Patel, Jacob Beiriger, Kalena Liu, Zachary Urdang, Julia Croce, Molly Wolfson, Jacob Hulswit, Olivia Giglio, Jacob B. Hunter, Irina L. Middleton Apr 2025

Ototoxicity Monitoring: The Evolution Of A Protocol For Head And Neck Cancer Patients, Jena Patel, Jacob Beiriger, Kalena Liu, Zachary Urdang, Julia Croce, Molly Wolfson, Jacob Hulswit, Olivia Giglio, Jacob B. Hunter, Irina L. Middleton

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

OBJECTIVE: We evaluated an ototoxicity monitoring program (OMP) for improving audiologic follow-up in head and neck cancer (HNC) patients.

STUDY DESIGN: Retrospective cohort study.

SETTING: Tertiary academic center.

METHODS: Two hundred and forty patients were recommended for chemotherapy between January 2017 and June 2022. An OMP was implemented in March 2021; every patient received an audiology referral and was contacted to schedule a pretreatment audiogram. Patients were divided into pre-OMP and post-OMP cohorts. Main outcome measures included rates of pretreatment audiograms, posttreatment audiograms, posttreatment otologic symptoms, and hearing aid utilization.

RESULTS: There were 131 patients evaluated pre-OMP and 109 evaluated …


Acculturation, Social Support, And Immigration-Related Stressors: Impact On Depression Among Single Mother Immigrants In The United States, Comfort Payne Apr 2025

Acculturation, Social Support, And Immigration-Related Stressors: Impact On Depression Among Single Mother Immigrants In The United States, Comfort Payne

Walden Dissertations and Doctoral Studies

Depression is a prevalent mental health condition that disproportionately affects immigrant single mothers in the United States, whose risk is heightened by unique vulnerabilities. The interplay between acculturation, social support, and economic burden in this population is underexplored. This quantitative, cross-sectional study examined the relationship between various factors and depression using 2020–2022 National Health Interview Survey data. Inclusion criteria were single immigrant mothers aged 19–60 years, who had lived in the U.S. for at least one year, had one or more dependent children, and self-reported depression status. The socioecological model provided a lens for identifying how individual, interpersonal, and structural …


Development Of End-Of-Life Educational Module For Nurses, Kari Mcclain Apr 2025

Development Of End-Of-Life Educational Module For Nurses, Kari Mcclain

Walden Dissertations and Doctoral Studies

End-of-life (EOL) care is given to patients and their families near the end of the patient’s life or when a patient or family member chooses to stop any treatment they are receiving to either cure or control their disease process. Having discussions regarding end-of-life and dying has proven to be difficult and uncomfortable for most healthcare professionals, whether they are providers or nurses at the bedside. Part of the reason for the discomfort in having these discussions is twofold. First, healthcare professionals are trained to do what they can to save a person's life. Therefore, there is a lack of …


Interlibrary Loan And Document Delivery Services: Evidence-Based Practice Council Monthly Meeting, Evelyn Wang, Ingrid Hendrix, Kristin Proctor Apr 2025

Interlibrary Loan And Document Delivery Services: Evidence-Based Practice Council Monthly Meeting, Evelyn Wang, Ingrid Hendrix, Kristin Proctor

HSLIC Faculty and Staff Instructional Resources

This presentation provides an overview of interlibrary loan (ILL) and document delivery services offered by the UNM Health Sciences Library and Informatics Center (HSLIC). It includes detailed information on service types, eligibility criteria, costs, processing times, restrictions, and how to request materials. The presentation aims to guide UNM Health Sciences affiliates in accessing resources efficiently to support research, education, and clinical practice.


Bargaining Across Borders: The Prevalence Of Collective Bargaining Agreements In American Sports And The Potential Implementation Of The American Model Into The English Premier League, Bryce Goodwyn Apr 2025

Bargaining Across Borders: The Prevalence Of Collective Bargaining Agreements In American Sports And The Potential Implementation Of The American Model Into The English Premier League, Bryce Goodwyn

Jeffrey S. Moorad Sports Law Journal (1994 - )

No abstract provided.


The Grand Narratives: The Rise And Fall Of Universal Philosophical Systems, Gavin S. Litchford Apr 2025

The Grand Narratives: The Rise And Fall Of Universal Philosophical Systems, Gavin S. Litchford

Senior Honors Theses

This thesis reviews the development of narrative and systematic methods of argumentative legitimation in the Western tradition of philosophy from its conception until the present day. Utilizing both primary sources from central figures in key movements within this development process and supplementary secondary sources, this analysis notes which systems were used as appeals to higher authority and the trends in the adoption and transformation of new models. It is demonstrated that the Enlightenment era punctuated a progression begun in the premodern era from simple, cultural narratives to individualized, subjective, and self-perpetuating Grand Narrative systems, and that it generated the preconditions …


Alterations In Dna Methylation, Proteomic, And Metabolomic Profiles In African Ancestry Populations With Apol1 Risk Alleles, Xinruo Zhang, Ashley W Scadden, Amarnath Marthi, Victoria L Buchanan, Yishu Qu, Kendra R Ferrier, Brian D Chen, Mariaelisa Graff, Julian Avila, Eric Boerwinkle, Steven Buyske, Clary B Clish, Dan Cruz, Myriam Fornage, Robert E Gerzsten, Christopher R Gignoux, Lashaunta Glover, Lifang Hou, Anne E Justice, Charles Kooperberg, Holly Kramer, Leslie Lange, Ruth J F Loos, Tara Matise, Josyf C Mychaleckyj, Opeyemi A Olabisi, Ulrike Peters, Laura M Raffield, Alex P Reiner, Stephen S Rich, Jerome I Rotter, Kent D Taylor, Bing Yu, Yinan Zheng, Kari E North, Amy K Mottl, Heather M Highland, Maggie A Stanislawski Apr 2025

Alterations In Dna Methylation, Proteomic, And Metabolomic Profiles In African Ancestry Populations With Apol1 Risk Alleles, Xinruo Zhang, Ashley W Scadden, Amarnath Marthi, Victoria L Buchanan, Yishu Qu, Kendra R Ferrier, Brian D Chen, Mariaelisa Graff, Julian Avila, Eric Boerwinkle, Steven Buyske, Clary B Clish, Dan Cruz, Myriam Fornage, Robert E Gerzsten, Christopher R Gignoux, Lashaunta Glover, Lifang Hou, Anne E Justice, Charles Kooperberg, Holly Kramer, Leslie Lange, Ruth J F Loos, Tara Matise, Josyf C Mychaleckyj, Opeyemi A Olabisi, Ulrike Peters, Laura M Raffield, Alex P Reiner, Stephen S Rich, Jerome I Rotter, Kent D Taylor, Bing Yu, Yinan Zheng, Kari E North, Amy K Mottl, Heather M Highland, Maggie A Stanislawski

Faculty, Staff and Student Publications

Key Points:

  1. We aimed to elucidate potential methylation, proteomic, and metabolomic mechanisms by which APOL1 variants may be linked to kidney disease.

  2. We report distinct methylation profiling between APOL1 risk allele carriers and noncarriers, many near APOL gene family.

  3. We report higher APOL1 protein and lower C18:1 cholesteryl ester in two risk allele carriers.

Background: The APOL1 high-risk haplotype has been associated with CKD and the deterioration of kidney function, particularly in populations with West African ancestry. However, the mechanisms by which APOL1 risk variants increase the risk for kidney disease and its progression have not been fully elucidated.

Methods: …


Mechanistic Insights Into The Structure-Based Design Of A Cspz-Targeting Lyme Disease Vaccine, Kalvis Brangulis, Jill Malfetano, Ashley L Marcinkiewicz, Alan Wang, Yi-Lin Chen, Jungsoon Lee, Zhuyun Liu, Xiuli Yang, Ulrich Strych, Dagnija Tupina, Inara Akopjana, Maria-Elena Bottazzi, Utpal Pal, Ching-Lin Hsieh, Wen-Hsiang Chen, Yi-Pin Lin Apr 2025

Mechanistic Insights Into The Structure-Based Design Of A Cspz-Targeting Lyme Disease Vaccine, Kalvis Brangulis, Jill Malfetano, Ashley L Marcinkiewicz, Alan Wang, Yi-Lin Chen, Jungsoon Lee, Zhuyun Liu, Xiuli Yang, Ulrich Strych, Dagnija Tupina, Inara Akopjana, Maria-Elena Bottazzi, Utpal Pal, Ching-Lin Hsieh, Wen-Hsiang Chen, Yi-Pin Lin

Faculty, Staff and Students Publications

Borrelia burgdorferi (Bb) causes Lyme disease (LD), one of the most common vector-borne diseases in the Northern Hemisphere. Here, we solve the crystal structure of a mutated Bb vaccine antigen, CspZ-YA that lacks the ability to bind to host complement factor H (FH). We generate point mutants of CspZ-YA and identify CspZ-YAI183Y and CspZ-YAC187S to trigger more robust bactericidal responses. Compared to CspZ-YA, these CspZ-YA mutants require a lower immunization frequency to protect mice from LD-associated inflammation and bacterial colonization. Antigenicity of wild-type and mutant CspZ-YA proteins are similar, as measured using sera from infected people or immunized …


Structural Updates To The Implant And Refill Needle Of The Port Delivery Platform, Dante J. Pieramici, Peter A. Campochiaro, Margaret Chang, Ian Pearce, Carl D. Regillo, Shamika Gune, Nancy Holekamp, Carlos Quezada-Ruiz, Shrirang V. Ranade, Natasha Singh, Geoffrey Wise, Joshua Horvath Apr 2025

Structural Updates To The Implant And Refill Needle Of The Port Delivery Platform, Dante J. Pieramici, Peter A. Campochiaro, Margaret Chang, Ian Pearce, Carl D. Regillo, Shamika Gune, Nancy Holekamp, Carlos Quezada-Ruiz, Shrirang V. Ranade, Natasha Singh, Geoffrey Wise, Joshua Horvath

Wills Eye Hospital Papers

PURPOSE: The purpose of this study was to report the impact of component-level changes and manufacturing process improvements on septum durability in the ocular implant of the Port Delivery Platform (PD-P), more commonly known as the Port Delivery System with ranibizumab (PDS) with its current formulation.

METHODS: Laboratory tests were conducted to determine (1) the bond strength of the septum to the overmold, (2) the amount of force utilized for the refill needle to puncture the septum, and (3) septum durability over 50 years. To simulate multiple refill-exchanges over long-term clinical use, implants were aged at elevated temperature in saline …


Predictors Of Political Participation Of U.S. Social Workers: The Mediating Effect Of Confidence, Maria Wathen, Rachel A. Young, Amy Krings, Teresa Kilbane Apr 2025

Predictors Of Political Participation Of U.S. Social Workers: The Mediating Effect Of Confidence, Maria Wathen, Rachel A. Young, Amy Krings, Teresa Kilbane

Social Work: School of Social Work Faculty Publications and Other Works

What factors are associated with social workers’ political participation, and how does political confidence mediate those relationships? To answer this question, data were collected in 2020 through an original online survey of members of the U.S.-based National Association of Social Workers (NASW). Informed by self-efficacy theory, researchers conducted a structural equation modeling (SEM) path model with political participation as the outcome variable, and political confidence as a mediating variable. Exogenous variables included: one’s self-reported political orientation, belief that social work has a political mandate, gender, and knowledge about how to effectively participate in politics. Results indicate that high political confidence …


A Folding-Docking-Affinity Framework For Protein-Ligand Binding Affinity Prediction, Ming-Hsiu Wu, Ziqian Xie, Degui Zhi Apr 2025

A Folding-Docking-Affinity Framework For Protein-Ligand Binding Affinity Prediction, Ming-Hsiu Wu, Ziqian Xie, Degui Zhi

Faculty, Staff and Student Publications

Accurate protein-ligand binding affinity prediction is crucial in drug discovery. Existing methods are predominately docking-free, without explicitly considering atom-level interaction between proteins and ligands in scenarios where crystallized protein-ligand binding conformations are unavailable. Now, with breakthroughs in deep learning AI-based protein folding and binding conformation prediction, can we improve binding affinity prediction? This study introduces a framework, Folding-Docking-Affinity (FDA), which folds proteins, determines protein-ligand binding conformations, and predicts binding affinities from three-dimensional protein-ligand binding structures. Our experimental results indicate that FDA performs comparably to state-of-the-art docking-free methods. We anticipate that our proposed framework serves as a starting point for integrating …


A Scoping Review Of Omop Cdm Adoption For Cancer Research Using Real World Data, Liwei Wang, Andrew Wen, Sunyang Fu, Xiaoyang Ruan, Ming Huang, Rui Li, Qiuhao Lu, Heather Lyu, Andrew E Williams, Hongfang Liu Apr 2025

A Scoping Review Of Omop Cdm Adoption For Cancer Research Using Real World Data, Liwei Wang, Andrew Wen, Sunyang Fu, Xiaoyang Ruan, Ming Huang, Rui Li, Qiuhao Lu, Heather Lyu, Andrew E Williams, Hongfang Liu

Faculty, Staff and Student Publications

The Observational Medical Outcomes Partnership (OMOP) common data model (CDM) supports large-scale research by enabling distributed network analyses. However, the breadth of its adoption in cancer research is not well understood. We conducted a scoping review to describe the adoption of the OMOP CDM in cancer research. A total of 49 unique articles were included in the review, with 30 on the data analysis theme, and 20 on the infrastructure theme. This review highlighted that while the OMOP CDM ecosystem has enabled successful data support for cancer research, particularly for collaborative studies, ongoing model development and iterative improvement remain needed …