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Engineering Hiv-1 Env Protein To Elucidate In Situ Structural Dynamics Of Env, Narendra Kumar Gonepudi May 2025

Engineering Hiv-1 Env Protein To Elucidate In Situ Structural Dynamics Of Env, Narendra Kumar Gonepudi

Biotechnology Theses

The HIV-1 Envelope (Env) glycoprotein trimers undergo structural changes upon interacting with host receptor CD4 and coreceptors (CCR5/CXCR4) for virus entry. As the only surface-exposed viral protein, Env is a key antibody target but evades recognition through structural changes. Studying Env dynamics with respect to the coreceptor binding region (V3 loop) provides insights into virus entry and immune evasion. Fluorescence labeling via genetic code expansion (amber–TAG suppression) offers a minimally invasive approach for fluorescence microscope-based Env dynamics studies. Here, two V3-related dual-amber Env constructs (A135TAG-P308TAG, P308TAG-E395TAG) were generated by incorporating two non-canonical …

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Illinois State University Salaries Fy2025 Update, Illinois State University May 2025

Illinois State University Salaries Fy2025 Update, Illinois State University

Illinois State University Salaries

Includes two sections: administrative professional and civil service salaries, and non-tenure track, tenure track, and faculty associate salaries.

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Role Of Hdac1 In Type I Ifn Production By Macrophages And Dendritic Cells In Response To Tlr3 Stimulation And Mycobacterium Tuberculosis Infection, Andy Omeje May 2025

Role Of Hdac1 In Type I Ifn Production By Macrophages And Dendritic Cells In Response To Tlr3 Stimulation And Mycobacterium Tuberculosis Infection, Andy Omeje

Biotechnology Theses

In this study we explored the role of histone deacetylases (HDACs), a group of epigenetic regulators, in production of type I interferon (IFN) by macrophages and dendritic cells (DCs) in response Mycobacterium tuberculosis (Mtb) infection and Poly I:C, a viral RNA mimic, stimulation. Human monocyte derived macrophages (MDMs) and DCs (MDDCs) stimulated with either Poly I:C or infected with Mtb produced elevated IFN-β and this was inhibited both at the protein and mRNA levels by 4-(dimethyl amino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide (DHOB) and CAY10603 (CAY), chemical inhibitors targeting HDAC1. This was further supported by THP1-derived macrophages with HDAC1 knockdown producing reduced IFN-β …

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Early Childhood Teachers’ Perspectives On The Challenges Of Closing The African American Achievement Gap, Cherie Mcelroy-Burch May 2025

Early Childhood Teachers’ Perspectives On The Challenges Of Closing The African American Achievement Gap, Cherie Mcelroy-Burch

Walden Dissertations and Doctoral Studies

There is a persistent academic achievement gap between African American students and their White peers in Grades 1–3. Federal and state governments have made numerous efforts, implemented policy changes, and allocated more resources to struggling school districts, yet the disparity in academic achievement persists. The purpose of this basic qualitative study was to explore early childhood teachers’ perspectives on the challenges of closing the achievement gap between African American students and their White peers in Grades 1–3. The conceptual framework for this study was based on Coll and Lamberty’s model of developmental competencies in minority children. The research question for …

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Illuminating The Iceberg: Brain Science And Punitive Damages In Libel Cases, Catherine J. Cameron May 2025

Illuminating The Iceberg: Brain Science And Punitive Damages In Libel Cases, Catherine J. Cameron

Tulsa Law Review

No abstract provided.

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Leading The Way: Preparing School Psychologists In Postsecondary Transition Training, Kaiya Joy Dawson May 2025

Leading The Way: Preparing School Psychologists In Postsecondary Transition Training, Kaiya Joy Dawson

Theses and Dissertations

Students with disabilities face significant challenges in achieving postsecondary success, yet training on postsecondary transition planning within school psychology graduate programs remains limited. A content analysis of 252 accredited school psychology programs in the United States revealed major gaps in transition training, with only 1.6% of programs covering all critical domains. Results indicated that 67% of programs include some transition training in at least one domain. Family engagement (42%) and program structure (30%) had the most training, then interagency collaboration (20%), student focused planning (3%) and student development (6%). Notably, programs with larger cohort sizes were correlated with more transition …

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Understanding The Delivery Of Music Learning In Nsw Public Schools: Primary Teachers' Survey - New South Wales, Rebecca Taylor, Daniel Edwards May 2025

Understanding The Delivery Of Music Learning In Nsw Public Schools: Primary Teachers' Survey - New South Wales, Rebecca Taylor, Daniel Edwards

School and system improvement

The Music Education: Right from the Start Primary Teachers’ Survey New South Wales was conducted to understand the delivery of music education in NSW Department of Education (the department) public primary schools and to provide baseline data for policy and program development. This broad-ranging survey of teachers and representatives from 706 New South Wales public primary schools. The results highlight the status of music education in NSW public primary schools, demonstrating teachers' need for better resources, improved preparation in Initial Teacher Education (ITE), increased access to quality professional learning, and integration of music into the broader curriculum.

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Integrating Community Assets, Place-Based Learning, And Career Development Through Project-Based Learning In Rural Settings, Denae Kizys, Christine Lotter Ph.D., Lucas Perez, Rachel Gilreath, Dodie Limberg May 2025

Integrating Community Assets, Place-Based Learning, And Career Development Through Project-Based Learning In Rural Settings, Denae Kizys, Christine Lotter Ph.D., Lucas Perez, Rachel Gilreath, Dodie Limberg

Faculty Publications

Our study investigates the first year of a two-year place-based education (PBE) professional development model that focuses on career development in rural middle schools through project-based learning (PBL) units. Rural science, technology, engineering, and mathematics (STEM) educators face unique challenges, including geographic isolation, limited resources, and reduced access to professional development opportunities, which can hinder the effective integration of career-oriented learning in the classroom. We addressed these challenges by implementing professional development in which school counselors and teachers collaborate to design PBL units aligned with rural community local needs and STEM careers. Using a descriptive multiple-case study methodology to document …

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2025 Commencement Program, New York Law School May 2025

2025 Commencement Program, New York Law School

Commencement Programs

No abstract provided.

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Disrupting And Facilitating: The Dual Role Of Generative Ai In Reshaping Power, Engagement, And Collaboration Within Organizations, Zain Khalid Baz Haddadin May 2025

Disrupting And Facilitating: The Dual Role Of Generative Ai In Reshaping Power, Engagement, And Collaboration Within Organizations, Zain Khalid Baz Haddadin

Student Theses and Dissertations

This study explores how Generative Artificial Intelligence (GenAI) is reshaping power, trust, engagement, and collaboration in communication-focused workplaces. Guided by a constructivist lens and informed by change management theory, it draws on eight semi-structured interviews and a survey of 40 professionals across agency, corporate, and academic roles. Findings reveal that GenAI does not fully flatten hierarchies, it subtly thins them, enabling junior staff to contribute to strategic conversations earlier while decision rights remain centralized. Trust is highly contextual, shaped by task sensitivity, prompt clarity, and user confidence. GenAI’s impact on engagement was mixed: some participants felt energized; others described increased …

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Using Ai As A Responsible Technology - A Guide To The Future Of Work, Eric F. Martinez-Valerio Mr. May 2025

Using Ai As A Responsible Technology - A Guide To The Future Of Work, Eric F. Martinez-Valerio Mr.

Student Theses and Dissertations

The capstone project, Using AI as A responsible Technology – A guide to the future of work is culmination of the last 2 years while in the Masters in Corporate Communications program at Baruch College. It is a training guide framework that is built upon the current discussions on the rise of Generative Artificial Intelligence (GenAI) in the workplace in recent years and aims to help organizations bridge the real time knowledge gap that is forming between individuals who have been using GenAI already and individuals who have not yet engaged with this new technology altogether. The framework for this …

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Utah People And Environment Poll 2024/25 Descriptive Report, Jessica Schad, Sydney Fisk, Zubair Barkat May 2025

Utah People And Environment Poll 2024/25 Descriptive Report, Jessica Schad, Sydney Fisk, Zubair Barkat

Utah People and Environment Poll (UPEP)

In spring of 2023, faculty and graduate students at Utah State University (USU) started the Utah People and Environment Poll, or UPEP, to survey adult Utah residents about their perceptions on environmental issues of importance to the state. From November 2024 to January 2025 the second iteration of the survey was conducted. While some questions remained the same, others were added to account for new interests of the team and emergent environmental issues of interest.

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Assessment Of Graduate Admission Requirements Aimed At Predicting Student Outcomes, William Pratt, Robert Greve, Michael Williams, Suye Wang, Evan Shough May 2025

Assessment Of Graduate Admission Requirements Aimed At Predicting Student Outcomes, William Pratt, Robert Greve, Michael Williams, Suye Wang, Evan Shough

International Journal for Business Education

The purpose of this study is to measure the appropriateness of the existing admissions requirements as related to the likelihood of graduation. We employ a five-year sample of students admitted into the graduate program and selected a cutoff date to allow sufficient time for most of each cohort to complete their studies. Following the general structure of Pratt (2015) this study assesses the appropriateness of criteria employed to evaluate graduate program applicants. The findings of our study demonstrate that undergraduate performance, GPA, and work experience can provide sufficient information for qualifying candidates into a graduate business program. Furthermore, our findings …

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A Crisis Of Craft: Creative Writing In The American University, Brenna E. Derbish May 2025

A Crisis Of Craft: Creative Writing In The American University, Brenna E. Derbish

Undergraduate Honors Theses

In this essay, I aim to analyze the changing nature of the Creative Writing MFA through the lens of the American culture that shaped it. In the 1930s, creative writing in American universities began to take shape, citing itself as a way to reform the philological study of literature into a more active field, a way for the common person to learn through creativity and self-expression. However, as the number of MFA programs in the nation continued to rise, admittance became increasingly selective, with many universities accepting only between 5 and 10% of their applicants. This increase in exclusivity, coupled …

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Adhd Diagnosis And Treatment Within Ethnic Minority Groups, Dianthe Hoang May 2025

Adhd Diagnosis And Treatment Within Ethnic Minority Groups, Dianthe Hoang

Undergraduate Honors Theses

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder that is commonly diagnosed in childhood, and the National Survey of Children’s Health reported that ADHD had a prevalence of around 6.1 million children aged 2-17 years old (NSCH, 2016). This review discusses the cultural and socioeconomic barriers that contribute to the underdiagnosis and treatment in members of ethnic minority communities. Black, Hispanic, Native American, and Asian adults received less mental health care compared to White Americans. Previous findings indicated that cultural factors, such as misinterpretation of symptoms from families and teachers and cultural perceptions of mental health, contributed to disparities …

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The Effects Of Family Cohesion On The Relationship Between Trauma And State-Level Social Policy Provision In The United States, Brandon Kendall Ross Fielding May 2025

The Effects Of Family Cohesion On The Relationship Between Trauma And State-Level Social Policy Provision In The United States, Brandon Kendall Ross Fielding

Dissertations and Theses

This dissertation examines how childhood trauma and family cohesion interact to shape state-level social policy generosity in the United States. The study begins with a multilevel quantitative analysis using data from the National Survey of Children’s Health and the State Safety-Net Generosity Index to assess how individual-level experiences of trauma and family support relate to state-level welfare generosity. Two trauma indices--one focused on adverse childhood experiences and bullying, and the other on food-related hardship--are used to explore how trauma influences attitudes toward public assistance, and whether family cohesion moderates this relationship. Results from marginal effects analyses indicate that family cohesion, …

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Introduction: Mother Tongue As Global Politics, Jessica Chandras, Joshua Babcock May 2025

Introduction: Mother Tongue As Global Politics, Jessica Chandras, Joshua Babcock

UNF Faculty Research and Scholarship

For racialized speakers living in the wake of colonial modernity, “mother tongues” persist as perilous, precarious terrain. Far from being a straightforward linguistic resource or a totalizing, self-evident identity marker, “mother tongue” is always positioned, partial, and political. As a category, “mother tongue” encompasses projects across disparate sites, histories, and interactional grounds beyond South Asia, where the concept has been most extensively elaborated. Articles in this collection trace the links among collective national identities, individuated personhood, and the denotational codes that get made to refract language-community attentions—not just a group's language, but more essentially, their “mother tongue.” What transformations, investments, …

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Setting Up Students For Success: Analysis Of Effectiveness Of Mathematics Placement, Jeff Carvell, Jason Ho, David Klanderman, Sarah Klanderman May 2025

Setting Up Students For Success: Analysis Of Effectiveness Of Mathematics Placement, Jeff Carvell, Jason Ho, David Klanderman, Sarah Klanderman

University Faculty Publications and Creative Works

How do we e!ectively and equitably place students into math classes in a way that provides them the best chance of success? As many higher education institutions veer away from placement based on standardized testing, many departments are seeking placement alternatives that will properly support students. Additionally, math placement determines not only a student’s mathematics courses but also influences their progress in related fields, including physics, chemistry, engineering, and more. This paper will describe three di!erent existing placement systems at each of our liberal arts institutions as well as the a!ordances and constraints of each approach. Further, we analyze data …

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Myocardin Effector Proteins Affect Tgf-Beta-Induced Myofibroblast Differentiation In Ipf Cells, Allison Gonzalez May 2025

Myocardin Effector Proteins Affect Tgf-Beta-Induced Myofibroblast Differentiation In Ipf Cells, Allison Gonzalez

Biotechnology Theses

Idiopathic pulmonary fibrosis (IPF) is an incurable interstitial lung disease defined by the progressive, irreversible scarring of the tissues between the lung’s alveoli. To date, only two drugs have received approval for treatment. However, these medications are not considered cures since they do not stop the progression of the disease. A deeper understanding of the mechanisms underlying IPF could aid in discovering a cure. We recently found that myocardin (MyoCD) regulates SMAD2/3 transcription factors in the TGF-β signaling pathway and governs the genes involved in pleural fibrosis. However, it is unclear whether MyoCD plays a critical role in IPF by …

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Perianal Infections Update, Boris Garber, Jonathan Glauser May 2025

Perianal Infections Update, Boris Garber, Jonathan Glauser

Faculty Scholarship

Purpose of Review We describe the evaluation, treatment, and disposition of patients presenting with perianal and rectal complaints, specifically focusing on identifying and treating various infectious diseases affecting this area. Risk factors and preventative strategies are also discussed where known. Recent Findings Several professional medical associations, namely the World Society of Emergency Surgery and the American Association for the Surgery of Trauma, recently promulgated new guidelines concerning the diagnosis and management of common infectious rectal disorders [1]. The American College of Radiology also published its criteria for choosing appropriate imaging modalities for anorectal disease [2]. Additionally, new meta-analyses have been …

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A Seat At The Schoolhouse Table: Reimagining Education Through Afrofuturist And Womanist Theory, Natasha M. Capers May 2025

A Seat At The Schoolhouse Table: Reimagining Education Through Afrofuturist And Womanist Theory, Natasha M. Capers

Student Theses

“A Seat at the Schoolhouse Table: Reimagining Education Through Afrofuturist and Womanist Theory” critically examines how curriculum, even when well-intentioned, can perpetuate harm by excluding the lived experiences of marginalized communities—especially Black, Indigenous, and LGBTQIA+ students. Using a real middle school immigration assignment given to the author's son as a case study, this capstone deconstructs the structural biases embedded in curriculum design and proposes a radical reimagining through the liberatory lenses of Afrofuturism and Womanism. Blending scholarly inquiry, personal narrative, and community-based interviews, this project offers a restructured assignment that centers joy, identity, and speculative storytelling as tools for educational …

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Extreme Bandgap Polarization Doped Algan Layers On Bulk Aln For Pn-Diodes With An 8.5 Mv Cm−1 Breakdown Field And Forward Current Density Exceeding 20 Ka Cm−2, Tariq Jamil, Abdullah Al Mamun Mazumder, Muhammad Ali, Mafruda Rahman, Kenneth Stephenson, Grigory Simin, Asif Khan May 2025

Extreme Bandgap Polarization Doped Algan Layers On Bulk Aln For Pn-Diodes With An 8.5 Mv Cm−1 Breakdown Field And Forward Current Density Exceeding 20 Ka Cm−2, Tariq Jamil, Abdullah Al Mamun Mazumder, Muhammad Ali, Mafruda Rahman, Kenneth Stephenson, Grigory Simin, Asif Khan

Faculty Publications

In this paper we present a study of distribution polarization doped AlxGa1−xN layers and their use in quasi-vertical configuration pn-diodes which exhibited a high breakdown field of ∼8.5 MV cm−1 and a large forward current density (∼23 kA cm−2). We also establish their potential use in UVC light emitters by studying the optical emission from a quantum well inserted at the distribution polarization doped pn-junction interface.

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The Impact Of Functional Disabilities On The Quality Of Life Of Older U.S. Adults, Bernadette Lavender May 2025

The Impact Of Functional Disabilities On The Quality Of Life Of Older U.S. Adults, Bernadette Lavender

Walden Dissertations and Doctoral Studies

Among older U.S. adults, functional disabilities are critical determinants of quality of life (QoL), influencing mobility, social engagement, and independence. Despite growing evidence of these impacts, limited research examines how healthcare access, social support, and socioeconomic factors moderate this relationship. This quantitative study explored the effects of functional disabilities on QoL, operationalized through self-reported health, while examining the moderating roles of key social determinants. Using a cross-sectional design, secondary data from the Health and Retirement Study (HRS) were analyzed. The sample included 42,405 participants aged 60 years and above from all 50 states. Multiple regression analyses and ANOVA were employed …

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Mediating Models Of Depression, Anxiety, And Ptsd In Adults With Early Versus Late Autism Spectrum Disorder Diagnoses, Kaycee Malaki Dobson May 2025

Mediating Models Of Depression, Anxiety, And Ptsd In Adults With Early Versus Late Autism Spectrum Disorder Diagnoses, Kaycee Malaki Dobson

Walden Dissertations and Doctoral Studies

Adults are being diagnosed with autism at greater rates than in the past two decades. This research study examined whether the age of autism diagnosis impacts the severity of comorbid mental health disorders in adults formally diagnosed with autism. The Empathizing-Systemizing theory, which posits that autistic individuals systemize at greater rates, was applied to understand the link between age of autism diagnosis and two common comorbid disorders, depression (measured by the PHQ-9) and post-traumatic stress disorder (PTSD; measured by the PCL-5). Mediation analyses were used to explore these relationships on a convenience sample of 232 adults with autism. No significant …

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Creating Space For Climate Justice In Library And Information Science, Tami Oliphant, Tyler Youngman, Dan Hackborn, Lisa Nathan, Beth Patin May 2025

Creating Space For Climate Justice In Library And Information Science, Tami Oliphant, Tyler Youngman, Dan Hackborn, Lisa Nathan, Beth Patin

The Lender Center for Social Justice

This article explores the role of LIS in promoting climate justice, advocating for inclusive and sustainable information practices that address environmental inequities.

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We, “The People,” Deserve A Second Chance, Meghan Monahan May 2025

We, “The People,” Deserve A Second Chance, Meghan Monahan

The Scholar: St. Mary's Law Review on Race and Social Justice

No abstract provided.

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Artificial Intelligence Applications In Decision-Making For Disease Management A Scoping Review, Mohammadhiwa Abdekhoda, Fatemeh Ranjbaran Madiseh May 2025

Artificial Intelligence Applications In Decision-Making For Disease Management A Scoping Review, Mohammadhiwa Abdekhoda, Fatemeh Ranjbaran Madiseh

Sultan Qaboos University Medical Journal

Artificial intelligence (AI) has several potential applications in medicine, creating opportunities for reliable and evidence-based decision-making in disease management. To explore the practical aspects of AI in decision-making, this scoping review was conducted to identify AI applications in disease management using the PRISMA-ScR checklist. Data collection involved searching relevant keywords in Web of Science and Scopus databases in May 2023. Eligibility criteria for study inclusion and exclusion were established, and the review process adhered to the PRISMA-ScR checklist. A total of 80 extracted sub-themes were identified and categorised into 6 main themes: data processing and management, characterisation and analysis, prediction …

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Evaluation Of Challenges In The Open Data Services Industry Under Uncertainty: A Methodology Based On Artificial Intelligence And Digital Transformation, Eman Sayed, Gawaher Soliman Hussein May 2025

Evaluation Of Challenges In The Open Data Services Industry Under Uncertainty: A Methodology Based On Artificial Intelligence And Digital Transformation, Eman Sayed, Gawaher Soliman Hussein

Sustainable Machine Intelligence Journal

This paper proposes a novel multi-criteria decision-making (MCDM) framework based on Triangular Linguistic Neutrosophic Cubic Fuzzy Sets (TLNCFSs) integrated with the COBRA method to evaluate strategic alternatives addressing key challenges in the Open Data Services (ODS) industry. In the era of digital transformation and artificial intelligence (AI), open data initiatives face multifaceted obstacles, including regulatory compliance, data interoperability, public engagement, and sustainable governance. To assess effective strategies, this study considers five potential alternatives aligned with AI and digital transformation, evaluated against fourteen critical criteria spanning policy, technical, governance, strategic, economic, and human-centric dimensions. Expert assessments are collected using TLNCFSs to …

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Ypfs Lessons Learned Oral History Project: An Interview With Agustín Carstens, Agustín Carstens, Mercedes Cardona, Rosalind Z. Wiggins May 2025

Ypfs Lessons Learned Oral History Project: An Interview With Agustín Carstens, Agustín Carstens, Mercedes Cardona, Rosalind Z. Wiggins

Documents

No abstract provided.

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Downregulation Of Biofilm Formation Genes In Some Pathogenic Bacteria By Extracts From Two Algal Genera, Nishtiman S Hasan, Janan J Toma, Abdulilah S Ismaeil, Suzan A Shareef, Muhsin J Abdulwahid May 2025

Downregulation Of Biofilm Formation Genes In Some Pathogenic Bacteria By Extracts From Two Algal Genera, Nishtiman S Hasan, Janan J Toma, Abdulilah S Ismaeil, Suzan A Shareef, Muhsin J Abdulwahid

Baghdad Science Journal

Most infectious diseases are primarily caused by the growth of microorganisms called biofilms. The formation of bacterial biofilms enables microorganisms to inhabit biotic and abiotic surfaces which increases their resistance to antimicrobials. To control this issue, there is a critical need for novel approaches and compounds can suppress the expression or regulation of virulence genes. A potential method for disarming rather than eliminating bacterial pathogens is antivirulence therapy based on the blockage of biofilm pathways. In current study, the action of water, diethyl ether and acetone extraction on two types of algae namely Scenedesmus quadricauda and Chlorosarcinopsis eremi in their …

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