Digital Commons Network^™

Polygenic Scores For Obstructive Sleep Apnoea Reveal Pathways Contributing To Cardiovascular Disease, Nuzulul Kurniansyah, Satu J Strausz, Geetha Chittoor, Shreyash Gupta, Anne E Justice, Yana Hrytsenko, Brendan T Keenan, Brian E Cade, Brian W Spitzer, Heming Wang, Jennifer Huffman, Matthew R Moll, Bernhard Haring, Su Yon Jung, Laura M Raffield, Robert Kaplan, Jerome I Rotter, Stephen S Rich, Sina A Gharib, Traci M Bartz, Peter Y Liu, Han Chen, Myriam Fornage, Lifang Hou, Daniel Levy, Alanna C Morrison, Heather M Ochs-Balcom, Bruce M Psaty, Peter W F Wilson, Kelly Cho, Allan I Pack, Hanna M Ollila, Susan Redline, Daniel J Gottlieb, Tamar Sofer

Faculty, Staff and Student Publications

Background: Obstructive sleep apnoea (OSA) is a common chronic condition, with obesity its strongest risk factor. Polygenic scores (PGSs) summarise the genetic liability to phenotype and can provide insights into relationships between phenotypes. Recently, large datasets that include genetic data and OSA status became available, providing an opportunity to utilise PGS approaches to study the genetic relationship between OSA and other phenotypes, while differentiating OSA-specific from obesity-specific genetic factors.

Methods: Using race/ethnic diverse samples from over 1.2 million individuals from the Million Veteran Program, FinnGen, TOPMed, All of Us (AoU), Geisinger's MyCode, MGB Biobank, and the Human Phenotype Project, we …

Cross-Sectional Analysis Of Wound-Associated Soluble Factors In Early, Established, And Chronic Wounds Of Recessive Dystrophic Epidermolysis Bullosa Patients, Vitali Alexeev, Leonie Huitema, Taylor Phillips, Paras Patel, Mauricio Garza, Franziska Ringpfeil, Julio Salas-Alanis, Olga Igoucheva

Department of Dermatology and Cutaneous Biology Faculty Papers

BACKGROUND: Poorly healing wounds represent the primary health-related burden for hereditary recessive dystrophic epidermolysis bullosa (RDEB) patients. Contribution of wound-associated soluble constituents to wound progression remains not well defined.

OBJECTIVE: To conduct cross-sectional analysis of cytokine, chemokine, and growth factor in exudates from RDEB wounds and define changes associated with wound progression.

METHODS: Concentrations of selected cytokines, chemokines, and growth factors were evaluated by multiplex ELISA in eight blister fluids and 66 exudates from early, established, and chronic RDEB and five chronic venous ulcers (VU). A cross-sectional analysis was performed.

RESULTS: Our data demonstrated that proinflammatory CXCL8 and IL-1β tend …

Direct Upcycling Of Degraded Ncm Via Low-Temperature Surface Engineering For High Performance Lithium-Ion Batteries, Yu Wang, Chris Yuan

Faculty Scholarship

Upcycling degraded low-Ni cathode materials into Ni-rich alternatives offers significant economic and environmental benefits for lithium-ion battery production. However, the stability and safety of the upcycled materials remain challenging due to their aggressive composition. This study reports an innovative two-step upcycling method that integrates a coating process with a low-temperature annealing process, thereby successfully upcycling degraded NCM622 with a LiAlO2 coating layer. Through comprehensive characterization, the recovery of crystal structure and uniform LiAlO2 coating on the particle surface are confirmed by XRD and XPS results. As a result of structural recovery and surface engineering, upcycled NCM622 demonstrates an initial capacity …

Mesenchymal Stem Cells And Fibroblasts Contribute To Microvascular Proliferation In Glioblastoma And Are Correlated With Immunosuppression And Poor Outcome, Candice C Poon, Shelley M Herbrich, Yulong Chen, Anwar Hossain, Gregory N Fuller, Sonali Jindal, Sreyashi Basu, Daniel Ledbetter, Marc Macaluso, Lynnette M Phillips, Joy Gumin, Zhong He, Brittany C Parker Kerrigan, Sanjay K Singh, Pratishtha Singh, Mohammed Fayyad Zaman, Derek Ng Tang, Sangeeta Goswami, Frederick F Lang, Padmanee Sharma

Faculty, Staff and Student Publications

Microvascular proliferation (MVP) is a disease-defining hallmark of glioblastoma and other World Health Organization grade 4 gliomas. MVP also serves as a poor prognostic marker in various solid tumors. Despite its clinical significance, the mechanisms and biological consequences of MVP are controversial and remain unclear. In this study, we performed single-cell RNA sequencing on paired CD45-CD105+ vascular/perivascular stromal cells (PVSC) and CD45+CD105± immune cells from 16 primary glioma patient samples, both with and without MVP. This analysis revealed the presence of developmentally related mesenchymal stem cells alongside cancer-associated fibroblasts, pericytes, fibromyocytes, and smooth muscle cells within the CD45-CD105+ compartment. RNA …

2025-06-04 Saying A Beloved Goodbye To Graduating Spectator Editors, Leila Bunker

The Spectator Online

No abstract provided.

2025-06-04 The State Of Undergraduate Research At Seattle U: Suurj Volume 9, Henry Leyden

The Spectator Online

No abstract provided.

Asset Building For All, Starting At Birth: Emergence Of A Federal Policy And A Key Design Lesson, Michael Sherraden, Margaret M. Clancy, Jin Huang, Ray Boshara, Lissa Johnson

Center for Social Development Research

A proposal in the 2025 tax-reconciliation bill would provide federal Child Development Account–like accounts for all children born between 2024 and 2028, with a provision enabling children born in 2028 or after to open accounts. This Policy Brief is designed to inform public debate about the legislation through a discussion of the evidence underpinning the most fundamental of many lessons learned from SEED for Oklahoma Kids, the Center for Social Development’s long-running, randomized experiment with Child Development Account policy: the need for a centralized savings-plan platform.

Prediction Of Methotrexate Neurotoxicity Using Clinical, Sociodemographic, And Area-Based Information In Children With Acute Lymphoblastic Leukemia, Rachel D Harris, Olga A Taylor, Maria Monica Gramatges, Amy E Hughes, Mark Zobeck, Sandi Pruitt, M Brooke Bernhardt, Ashley Chavana, Van Huynh, Kathleen Ludwig, Laura Klesse, Kenneth Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Ashley Choi, Yuu Ohno, Melissa A Richard, Alanna C Morrison, Han Chen, Bing Yu, Philip J Lupo, Karen R Rabin, Michael E Scheurer, Austin L Brown

Center for Medical Ethics and Health Policy Staff Publications

Background: Methotrexate is a critical component of pediatric acute lymphoblastic leukemia (ALL) therapy that can result in neurotoxicity which has been associated with an increased risk of relapse. We leveraged machine learning to develop a neurotoxicity risk prediction model in a diverse cohort of children with ALL.

Methods: We included children (age 2-20 years) diagnosed with ALL (2005-2019) and treated in Texas without pre-existing neurologic disease. Clinical information was obtained by medical record review. Neurotoxicity occurring post-induction and prior to maintenance therapy was defined as neurologic episodes occurring within 21 days of methotrexate. Suspected cases were independently confirmed by 2 …

Assessment Of Water Quality Among Handwashing And Drinking Water Stations In Schools In Belize, 2022, Anh N Ly, Alexandra Kossik, Ary Sosa, Uriel Sosa, Dian Maheia, Yolanda Gongora, Russell Manzanero, Francis Morey, Melissa Diaz-Musa, Dennis Nichols, Adrianna Maliga, Kelsey Mcdavid, Christina Craig, Gerhaldine Morazan, Matthew Lozier, Kristy O Murray

Faculty, Staff and Students Publications

Water quality assessments are critical for ensuring timely responses to water-related concerns, particularly in low-resource areas with limited water, sanitation, and hygiene (WASH) infrastructure. In collaboration with the Belize Ministry of Health and Wellness and the Ministry of Education, Culture, Science and Technology, we conducted a survey on WASH infrastructure and resources among 221 schools. We identified 65 schools across all six districts of Belize for water quality testing. Among these 65 schools, 83% had at least one water sample that did not meet the WHO's recommended free chlorine residual level for drinking water. Additionally, coliforms and Escherichia coli were …

Nonstructural Roles Of Junctophilin-2 In The Heart, Daniel F Hutchison, Satadru K Lahiri, Kurt W Prins, Xander H T Wehrens

Faculty, Staff and Students Publications

Junctophilin-2 (JPH2) is an essential structural protein that maintains the integrity of junctional membrane complexes (JMCs) in cardiomyocytes, thereby playing its canonical role in excitation-contraction (E-C) coupling. Recent studies reveal novel, nonstructural functions of JPH2 in cardiomyocytes, including regulation of mitochondrial function, lipid metabolism, nuclear signaling, and innate immune responses. Calpain-mediated cleavage of JPH2 generates nuclear fragments, which differentially modulate stress responses. Moreover, full-length JPH2 also localizes to the nucleus, where it forms phase-separated nuclear droplets during oxidative stress. Collectively, these findings highlight JPH2 as a multifunctional protein with critical roles beyond its canonical structural function in E-C coupling.

Oxygen Saturation Targeting In The Neonatal Intensive Care Unit, Faeq Almudares, Bheru Gandhi, Jonathan Davies, Xanthi Couroucli, Natalie Villafranco, Nidhy Paulose Varghese, Milenka Cuevas Guaman, Charleta Guillory, Binoy Shivanna

Faculty, Staff and Students Publications

Oxygen (O2) is vital for cellular development, function, proliferation, and repair, underscoring its critical role in organogenesis. Both hypoxia (reduced tissue O2) and hyperoxia (excess tissue O2), when prolonged, can trigger inflammation and oxidative stress, contributing to acute and long-term cardiopulmonary and neurodevelopmental morbidity. In sick neonates, immature defense mechanisms and coexisting morbidities demand nuanced and sometimes opposing strategies for O2 saturation targets and therapeutic titration. Most current neonatal O2 targeting guidelines are based on animal models or small clinical studies, resulting in recommendations with limited evidence. This narrative review aims to provide an updated overview of the physiological roles …

Impact Of Sociodemographic Determinants On Enrollment Into Contemporary Lymphoma Clinical Trials: A Systematic Review, Jun Yang Jiang, Ang Li, Alexis Romero, Christopher R Flowers, Chijioke Nze

Faculty, Staff and Students Publications

While the incidence and survival associated with lymphoma have improved in recent years, outcome disparities related to sociodemographic factors such as age, sex, race, ethnicity, socioeconomic status (SES), and other social determinants of health (SDOH) remain prevalent in the modern era. Clinical trials are crucial for further improving outcomes, yet not all sociodemographic groups are equally represented in contemporary lymphoma trials. We conducted a systematic review of the literature evaluating the impact of SDOH on enrollment into clinical trials in the United States and identified 21 relevant studies. We confirmed that Black and Hispanic individuals are underrepresented in lymphoma clinical …

Career Impact Of The National Interprofessional Fellowship In Patient Safety: An Alumni Evaluation, Bradley V Watts, Kathleen Carluzzo, Blake F Webb, Kelley Arredondo

Faculty, Staff and Students Publications

Background: There has been a proliferation of health professions training programmes focused on quality and patient safety, but little information regarding the outcomes of these programmes. The purpose of this study was to examine the impact of an interprofessional quality and patient safety curriculum on career outcomes of interprofessional healthcare learners for the Veterans Affairs Patient Safety Fellowship.

Method: We conducted a survey-based assessment of 117 alumni of the Interprofessional Fellowship in Patient Safety assessing their satisfaction with the training program and career impacts.

Results: 84 of 117 alumni were located and participated in the assessment. Fellows entered the training …

Sustaining Progress: Investing In Adolescent Girls Amidst Global Challenges—Slide Deck, Coalition For Adolescent Girls

Adolescents and Young People

No abstract provided.

Linking Dna Methylation In Brain Regions To Alzheimer’S Disease Risk: A Mendelian Randomization Study, Hua Zhong, Jingjing Zhu, Shuai Liu, Dan Zhou, Quan Long, Chong Wu, Bingxin Zhao, Chao Cheng, Yaohua Yang, Qing Wu, Yong Wu, Changwei Li, Zhaoming Wang, Jianyong Wu, Xingyi Guo, Degui Zhi, Youping Deng, Lang Wu

Faculty, Staff and Students Publications

Aim: DNA methylation in brain regions represents a potential mechanism linking genetic variation to Alzheimer's disease (ad) risk, yet most studies have focused on blood-derived methylation markers. In this study, we conducted a systematic Mendelian randomization (MR) study to evaluate associations between predicted brain region-specific DNA methylation levels and ad risk, using methylation quantitative trait loci (mQTL) as genetic instruments.

Methods: We analyzed mQTLs from five human brain regions: cerebellum (CRBLM), frontal cortex (FCTX), causal pons (PONS), and temporal cortex (TCTX) from 600 individuals in Gibbs et al's study, as well as mQTLs from dorsolateral prefrontal cortex (DLPFC) of 543 …

Exploring The Pathway From Customer Sexual Harassment To Instigated Incivility In Service Employees, Fernanda Wolburg Martinez

Dissertations and Theses

The current study explores how and why customer sexual harassment (CSH) experienced by service workers may lead to instigated incivility towards customers in the same week. Specifically, following the tenets of Personality Systems Interaction theory (PSI) and the affective shift model, I hypothesized that week-level affective shifts mediate this relationship, such that upshifts in anxiety and downshifts in self-assurance govern changes in motivational and cognitive functions that impair the employee's ability to provide good customer service. Further, supervisor preventive behaviors and psychological detachment are proposed as interventions that may lead to a departure from the mistreatment spiral by weakening the …

Investigation Into Thermodynamic And Kinetic Phenomena In Arylation Reactions With Diaryliodonium Salts, Soocheta Jha

Dissertations and Theses

Benzenoid rings are fundamental structural motifs in organic chemistry, widely recognized for their prevalence in natural products, pharmaceuticals, agrochemicals, and functional materials. Transition metal-catalyzed arylation, using catalysts such as palladium, nickel, or copper, has revolutionized C-C, C-O, and C-N bond formation, offering broad substrate scope and high efficiency. Among the reagents developed for efficient aryl group transfer, diaryliodonium salts have emerged as particularly powerful tools. Diaryliodonium salts facilitate metal-free arylations across a broad spectrum of nucleophiles, offering high reactivity, operational simplicity and environmental compatibility. The versatility of diaryliodonium salts has led to their widespread adoption as efficient arylating reagent in …

The Experience Of Being A Christian Public School Teacher, Carrie Birmingham

International Christian Community of Teacher Educators Journal

This research asks, “What is the experience of being a Christian teacher in a public school?” Analysis of semistructured interviews with 16 Christian public school teachers revealed that, while this experience is highly variable and contextualized, teachers experienced four common concerns, making visible how teachers’ religious identity shapes their purpose for teaching, their interactions with supports and oppositions, their values for themselves and for their students, and their perspectives on Christian witness and teaching in their public school settings.

Exploring The Relationship Between Classroom Management And Relational Leadership, Genie Kim, Nancy Ross

International Christian Community of Teacher Educators Journal

Our research examines teachers’ capacity to cultivate a learning environment conducive to students’ academic and social-emotional flourishing, specifically as it pertains to love and its intersection with classroom management. Utilizing Ross’ (2023) Relational Leadership Scale (RLS), coupled with an adapted version of Tschannen-Moran’s Teacher Efficacy Scale, we measured loving leadership, from the perspective of Teacher Candidates, as they observed their Associate/Host teachers’ behaviors/dispositions within the context of teaching students. The results of our study revealed a moderate positive correlation between classroom management and the overall RLS scores. It was found that teachers who engage in loving leadership behaviors were perceived …

Drawing Lines In The Sea: Indigenous Sovereignty Through The Coastal Zone, Tyler Hall

Washington Journal of Social & Environmental Justice

No abstract provided.

Factors Affecting Integration Of The Nurse Practitioner Workforce Into Health Systems: A Delphi Consensus Study, Joshua Porat-Dahlerbruch, Rebecca Clark, Brandon Dutchess, Nancy P. Blumenthal, Moriah E. Ellen

General Submissions: Clinical Settings Materials

Research has documented the positive impact of the nurse practitioner workforce on patient and system outcomes in multiple countries. Achieving these outcomes relies on successfully integrating the workforce into the health system. Research has reported negative effects of integration barriers on the ability for nurse practitioners to improve outcomes. Barriers include scope of practice restrictions, organizational climates inconducive to nurse practitioner care, and lacking mentorship. To design efficacious policies, organizational and national policy decision-makers require knowledge of the factors affecting the integration of this human resource into care settings. No research has synthesized these factors into an easily understandable and …

Women's Learning For Community Peacebuilding, Robin Neustater

Peace and Conflict Studies

Around the world, every day, women work on building peace in their communities. Through various roles, paid and unpaid, women’s community care work is significant to the lives of individuals, families, communities, and the women themselves. Understandings of peace are varied, and often nuanced to the context and experience of who is defining peace. How women define peace will inform how they think about peacebuilding. Women engage in learning about peace and for their peacebuilding work, through nonformal and formal programs, and through experience and role models. Their learning to do peace is vital to getting things done. This article …

‘You’ And ‘We’ In #Womanlifefreedom: A Corpus-Based Discourse Analysis Of Collective Identities And Speech Acts In The Twitter’S Discourse Of Iranian Protests, Kimiya Roohani

Peace and Conflict Studies

This paper applies corpus linguistic discourse analysis to approach the social media discourse of a recent political movement in Iran, known as #WomanLifeFreedom and Mahsa Amini. The movement included vast protests in different parts of Iran and went viral on an international scale. Protesters relied heavily on social media, particularly Twitter, to determine strategies and support each other during the expansive calls. To address the discourse shaped in that platform, a corpus was compiled from the Twitter posts, named Mahsa Amini Tweets Corpus (MATC). Using this data collection and analysis method, the endeavour was to obtain a balance between quantitative …

Cadential Rhetoric And Separate Agencies: Split-Voice Pacs And Their Impact On Formal Closure In The Music Of Dvořák, Xieyi (Abby) Zhang

Gamut: Online Journal of the Music Theory Society of the Mid-Atlantic

This article analyzes three pieces by Dvořák that make use of a cadential device henceforth referred to as a split PAC: either the melody or the bass appears to cadence significantly before the other—often by several measures—and maintains a holding pattern until the other voice catches up. This paper begins by contextualizing split PACs within the existing formal theory of cadences. Then, using the analytical perspective of multiple agencies, this paper reads these cadential gestures as drivers of musical narrative that often have long-lasting implications for the remainder of the piece.

In Search Of Robe & Crown (Jamiaposh)

Old name/logo items (letterheads, seals, posters, etc.)

No abstract provided.

Detecting Physical Activity Using Wearable Sensor Data, Dipok Deb

Data Science and Data Mining

This study focuses on detecting physical activity using wearable sensor data, specifically distinguishing between walking and running. A dataset comprising accelerometer and gyroscope readings is used to train and evaluate various machine learning models, including logistic regression, random forest, k-nearest neighbors, naïve Bayes, and XGBoost. Extensive preprocessing, such as creating lag features and rolling statistics, is performed to enhance temporal data representation. The models are evaluated using metrics like accuracy, precision, recall, and F1 score. Incorporating lag and rolling features significantly improves model performance, with logistic regression achieving perfect scores across all metrics. These findings demonstrate the effectiveness of enhanced …

Leadership For East Africa

Vision and mission statements

No abstract provided.

Graduate School Of Media And Communications - Foundation Ceremony

Inaugural addresses and related documents

No abstract provided.

The Aga Khan School Of Nursing

University press releases and calendars

No abstract provided.

No. 42: Remittance Practices, Digital Technologies And The Ghana-Canada Migration Corridor, Naomi Sunu, Sujata Ramachandran

Migration and Food Security (MiFOOD) Network

Migrant remittances have been recognized as vital resources for the well-being of recipient households and communities, as well as for sustainable development in the Global South. However, these flows can be impeded by limitations in the infrastructure, financial systems, and regulatory environments of both sending and receiving countries, as exemplified by the high costs associated with remitting to sub-Saharan Africa. Consequently, the use of less secure but more affordable informal remittance channels persists. Driven by the rapid growth of fintech technologies in recent years, including mobile money and web-based platforms, the digitalization of remittance-sending and receiving processes has the potential …