Digital Commons Network^™

Amino Acid Transporter Lat1 (Slc7a5) Promotes Metabolic Rewiring In Tnbc Progression Through The L-Trp/Qprt/Nad+ Pathway, Margot Y. Fedoroff, Lei Zhao, Shaomin Wang, Alok Bhushan, Haifeng Yang, Karen M. Bussard, Stephen C. Peiper, Jun He

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Cancer cells uptake excessive nutrients by expressing higher levels of glucose and/or amino acid transporters to meet their increased energy demands. L-type amino acid transporter 1 (LAT1), is regarded as a cancer-specific transporter for the uptake of large neutral amino acids such as L-tryptophan. However, the mechanism by which LAT1 rewires cellular metabolism to promote cancer progression and chemoresistance have not yet been investigated.

METHODS: The protein levels of LAT1, p-PKM2, and p-LDHA were determined in breast cancer tissue arrays by immunohistochemistry staining followed by survival analysis. The orthotopic breast cancer models in mice, syngeneic breast cancer models, and …

Building Belonging Infrastructure In Cities: Arts/Culture-Based Critical Participatory Action Research And Youth, Kimberly Rae Nightingale

Dissertations and Theses

Belonging is a critical human need. Urban planning's history of bureaucratic expertise continues to champion the powerful, resulting in structures and procedures that still separate and damage city communities. This research challenges the current hegemony of urban planning that centers geography--the container of land--in its practice. Instead, centering the belonging of people to each other is the essential quality of healthy urban planning. A people-centered urban planning practice where the community's people are the experts and decision-makers of their own cities--and belonging is the primary objective--is long overdue.

Arts/culture-based critical participatory action research (PAR)--where the research questions, design, data collection, …

Recurrent De Novo Variants In The Spliceosomal Factor Crnkl1 Are Associated With Severe Microcephaly And Pontocerebellar Hypoplasia With Seizures, Sankalita Ray Das, Rosie Sullivan, Mischa S G Ruegg, Julia Horsfield, Jordan Doran, Gemma Poke, Nathalie De Vries, Sarah Duerinckx, Damien Lederer, Muzhirah Haniffa, Wee-Teik Keng, Gaik-Siew Ch'ng, David A Parry, Andrew P Jackson, Masamune Sakamoto, Naomichi Matsumoto, Noriko Miyake, Shin Nabatame, Hidetoshi Taniguchi, Emma Wakeling, Katrin Õunap, Pilvi Ilves, Ghayda Mirzaa, Andrew Timms, Emily Pao, Kimberly A Aldinger, William Dobyns, Axel Bohring, Beate Behre, Daniel G Calame, James R Lupski, Juan M Pascual, Marc Abramowicz, Gregory Gimenez, Louise S Bicknell

Faculty, Staff and Students Publications

Splicing is a complex process that is required to create the transcriptomic diversity needed for specialized functions in higher eukaryotes. The spliceosome contains more than 100 proteins and RNA molecules, which coordinate this dynamic process. Despite the ubiquity of splicing, pathogenic variants in spliceosomal components often cause a tissue-specific phenotype, hinting at further complexities that are not yet fully understood. We have identified a cohort of ten families with de novo missense variants in a spliceosomal component, CRNKL1, where nine individuals harbor one of two missense variants that both affect the same amino acid, Arg267. All affected individuals share a …

Genomic Rare Variant Mechanisms For Congenital Cardiac Laterality Defect: A Digenic Model Approach, Archana Rai, Jonathan Klonowski, Bo Yuan, Karen J Coveler, Zain Dardas, Iman Egab, Jiaoyang Xu, Philip J Lupo, A J Agopian, Dennis Kostka, Cecilia W Lo, S Stephen Yi, Bruce D Gelb, Christine E Seidman, Eric Boerwinkle, Jennifer E Posey, Richard A Gibbs, James R Lupski, Shaine A Morris, Zeynep Coban-Akdemir

Faculty, Staff and Students Publications

Laterality defects are defined by perturbations in the usual left-right asymmetry of organs. The genetic etiology that underlies congenital heart disease (CHD) is often unknown (less than 40%), so we used a digenic model approach for the identification of contributing variants in known laterality-defect-associated genes (n = 115) in the exome/genome sequencing (ES/GS) data from individuals with clinically diagnosed laterality defects. The unsolved ES/GS data were analyzed from three CHD cohorts: Baylor College of Medicine-Genomics Research to Elucidate the Genetics of Rare Diseases (BCM-GREGoR; n= 251 proband ES), Gabriella Miller Kids First Pediatric Research Program (Kids First; n = 158 …

Testosterone Deficiency And Treatments: Common Misconceptions And Practical Guidance For Patient Care, Mohit Khera, James M Hotaling, Martin Miner

Faculty, Staff and Students Publications

Introduction: Misconceptions about testosterone therapy are prevalent and there is an unmet need for a review of current literature that can be leveraged by physicians to deliver safe and effective care for men with hypogonadism.

Objectives: This review aims to address common misconceptions about testosterone therapy using current literature and synthesize practical guidance for clinicians with patients who are starting testosterone therapy.

Methods: A literature search of PubMed, Embase, CINAHL was carried out to identify associations between testosterone therapy and prostate cancer, cardiovascular risk, and hepatic toxicity; definitions of hypogonadism; and practical guidance for clinician with patients starting testosterone therapy. …

Hallmarks Of Stem Cell Aging, Thomas A Rando, Anne Brunet, Margaret A Goodell

Faculty, Staff and Students Publications

As organisms age, somatic stem cells progressively lose their ability to sustain tissue homeostasis and support regeneration. Although stem cells are relatively shielded from some cellular aging mechanisms compared with their differentiated progeny, they remain vulnerable to both intrinsic and extrinsic stressors. In this review, we delineate five cardinal features that characterize aged stem cells and examine how these alterations underlie functional decline across well-studied stem cell compartments. These hallmarks not only provide insight into the aging process but also serve as promising targets for therapeutic strategies aimed at rejuvenating stem cell function and extending tissue health span.

Brivaracetam Effectiveness And Patient-Reported Outcomes In Clinical Practice: Data From A 12-Month Prospective, Observational Study In The United States., Hina Dave, Michael R. Sperling, Hamada Hamid Altalib, Heidi Henninger, Roger J. Porter, Michael Gelfand, Prashant Dongre, Sami Elmoufti, Melinda S. Martin, Anne-Liv Schulz, Jacqueline A. French

Department of Neurology Faculty Papers

OBJECTIVE: Evaluate real-world effectiveness, patient-reported outcomes (PROs), and safety/tolerability of brivaracetam in patients (≥16 years) with focal-onset seizures currently receiving ≥ 1 antiseizure medication (ASM), and with historical or current use of levetiracetam, lamotrigine, oxcarbazepine, and/or carbamazepine.

METHODS: EP0088 was a 12-month, prospective, observational study of brivaracetam in a clinical practice setting in the US. Primary study outcome was brivaracetam retention at 12 months after brivaracetam initiation. Effect of brivaracetam on patients' perceptions of their health was assessed using Patient-Reported Outcomes Measurement Information System (PROMIS) short forms and Seizure-Related Disability Assessment Scale (SERDAS). Safety outcomes included incidence of treatment-emergent adverse …

“A Time Of Fire And Cataclysm”: The Centrality Of Cosmic War In Tolkien’S Round World Cosmologies, Kristine Larsen

Journal of Tolkien Research

In the etiological mythology of Middle-earth, heavenly battles routinely invoke astronomical events, signs of Melkor’s marring of the world or mighty weapons in his arsenal of destruction. In this conference paper I specifically focus on battles involving the Sun and Moon, especially in Tolkien's later "Round Earth" cosmologies, where the Sun Maiden is "ravished" by Melkor.

Gaining Insights Into Community Engagement Efforts: Learning From Preservice Stem Educators, Amy G. Maples, Lynn L. Hodge, Nick Kim

Journal of Community Engagement and Higher Education

This study seeks to extend research in the field by exploring literature examining preservice teachers’ perceptions of community engagement efforts. We then report findings from a thematic analysis of a survey conducted with teacher candidates at a university in the southeastern U.S. who took part in school- and community-based STEM events, and provide implications and suggestions for utilizing community engagement opportunities as a means of enriching preservice teachers’ understandings of local school and community contexts.

This Is Why We Do It: Faculty Motivations For Embracing Community-Engaged Pedagogy, Magdalena Denham, Lee M. Miller, Joyce K. Mccauley, Danica Schieber, Taylor L. Morrison, Chuck Drumm

Journal of Community Engagement and Higher Education

Institutions of higher education are increasingly highlighting community engagement activities to make the benefits of higher education more visible. The most transformational community engagement is linked to curriculum, so it is faculty who must incorporate community-engaged pedagogy. This content analysis of faculty narratives about community engagement reveals motivations for faculty to engage in this work. These findings connect to social capital theory and suggest a new direction for faculty development efforts to promote community engagement.

The Role Of Cultural Brokers In Community-Based Research, Rachel Boit, Joy Birabwa, Dhoha Altaki, Savannah Bayer, Michele Kamau, Linda Hestenes

Journal of Community Engagement and Higher Education

Cultural brokers play a critical role of helping researchers navigate cultural and language barriers to gain insight into communities. This paper focuses on one cultural broker who helped facilitate community-based research among the refugee community. Her professionalism, expertise and knowledge of the community made her a valuable resource for both the researchers and the community. This work acknowledges the position of power and privilege that cultural brokers hold in community research.

Book Publishing In A Changing Environment

Communication Research Trends

In 1982 Unesco held the first World Congress of Books in London. Its aim was to promote the idea of the 'reading society'. As if to underline ,he problem facing Unesco in achieving its aim, 1982 was also Information Technology Year in Britain. The juxtaposition of traditional and modern forms of communication is an apt symbol of the theme of this issue.

Since the time of Gutenberg the printed book has held a prominent place in the Western cultural and intellectual system. Today book production continues to increase around the world and developing countries are ever more anxious to combat …

Improving Children's Television

Communication Research Trends

Few areas of television programming have provoked such strong public concern and protest as children's programmes. Parents and educators fear that television may be disrupting the balanced development of children's personalities or implanting harmful values. Most of the early research on children's television was an attempt to determine more accurately whether content was truly violent or manipulative and whether violence, advertising or other content was having destructive effects.

This public reaction also sparked moves in the late 1960s to carefully design programmes such as Sesame Street which would be entertaining, instructive and contribute to the intellectual-emotional growth of the child. …

Stepping Up, Keeping On Track, And Pulling Your Own Weight: Collaborative Arts-Based Service-Learning Metaphors, Marcy Meyer

Journal of Community Engagement and Higher Education

In this study, the author explores metaphors related to students’ experiences conducting collaborative arts-based ethnographic research in a U.S. nonprofit organization. A metaphor analysis of 25 students’ essays revealed they were most likely to frame their experiences with arts-based service learning as a journey or a sports contest. The author examines the extent to which students’ metaphors legitimize or delegitimize arts-based service learning, as well as the degree of novelty that characterizes these metaphors. She explores the implications of her findings for teaching and promoting arts-based service learning in the academy.

Incorporating Community-Engaged Pedagogy In Online Classes: Benefits, Challenges, And Strong Practices, Emmy Price, Margaret Thomas-Evans

Journal of Community Engagement and Higher Education

Community-engagement in virtual classrooms comes with unique benefits and challenges. Between 2018-2021, technical writing e-service-learning students from Indiana University East (Richmond, Indiana) raised a total of $149,239 through grant writing projects. This e-servicelearning project gave students real-world experiences and opportunity to connect with local organizations, prompting one student to choose grant writing as a career. Many students were able to successfully obtain funding for their chosen nonprofits, giving students a sense of social responsibility.

Exploring The Impact Of A Middle Level School Therapy Dog On Students And Staff And Connections To Best Practices In Middle School Education, Brandye Nobiling, Sherry Maykrantz, Tara Downes, Joshua Nobiling

Current Issues in Middle Level Education

The presence of therapy dogs in schools has increased due to the growing body of research showing positive effects of assisted-animal interaction. But there is little published research on how an innovation such as a therapy dog connects to best practices in middle level education. The goal of the research was to use the Diffusion of Innovation (DOI) theory to connect the implementation of a therapy dog to the Association for Middle Level Education’s (AMLE) essential attributes and characteristics as well as components of the Centers for Disease Control and Prevention’s Whole School, Whole Community, Whole Child (WSCC) model. Focus …

"It Makes It More Real.”: Teacher Candidate Perceptions Of A Clinically-Rich Middle Grades Teacher Preparation Program, Shawn A. Faulkner, Michael Dicicco

Current Issues in Middle Level Education

The persistent divide between theory and practice in teacher education has long been a subject of concern among researchers and scholars (Darling-Hammond, 2006; Zeichner, 2010). This paper explores teacher candidate perceptions of a clinically-rich (NASUP, 2021) middle grades teacher preparation program that has worked to create a “third space” (Zeichner, 2010) through a school-university partnership with a local middle school. Semi-structured interviews were conducted with teacher candidates (n=23) at the time of program completion. Findings suggest teacher candidates felt prepared and valued clinically-based activities and experiences. Teacher candidates suggest future improvements to the program should include more experiences tied to …

Using Text Clusters To Support Student Imagining, Wondering, Questioning, And Discovering, William P. Bintz

Current Issues in Middle Level Education

This article describes an unexpected playground experience that occurred between the author, a reading educator and former middle grades teacher, and his six-year-old granddaughter. The experience became the inspiration and impetus to provide an introduction to, and a rationale for, the concept of text clusters to middle grades teachers. The concept of developing and implementing text clusters in the classroom is driven by inquiry and based on one question: How can middle school teachers develop and implement text clusters to help their students actively engage in imagining, wondering, questioning, and discovering? It shares and illustrates examples of text clusters. It …

From Observation To Ethical Inquiry: Course Redesign In Middle Level Educator Preparation, Sarah Straub, Elizabeth Gound

Current Issues in Middle Level Education

This manuscript explores the transformative impact of ethical engagement in the course MLGE 3301: Adolescent Learning, designed for pre-field students in an educator preparation program. Focused on middle-grade education and special education, this course incorporates a significant service learning component, with undergraduate students spending 10 service hours in middle school classrooms and conducting interviews with middle school students. The purpose of the interviews is to enable pre-field students to engage with middle school students and use the insights gained to reflect on the alignment between their coursework in adolescent learning theory and real-world experiences. Two professors leading the course recognized …

Youth And Rock Music

Communication Research Trends

In 1954 the nineteen-year-old Elvis Presley suddenly caught the enthusiasm of millions of teenagers with a new form of pop music called rock 'n' roll. Five years later, sociologist James Coleman, in a massive survey of American adolescents, confirmed that pop music - especially rock 'n' roll - was the major form of entertainment of young people. Research continues to show that around the world teenage interest in rock music influences the television programmes they watch, the magazines they read, the cafes, youth clubs and dances they go to, and the 'necessary tools' they seek to own (transistor radios, record …

Social Support In Hypertension Treatment Adherence: A Qualitative Study In Ghana, Rose Therra Nortey

DNP and Student Works

Background: Hypertension is a leading global public health concern, contributing to 55.6% of annual mortality and affecting nearly one billion individuals worldwide.

Objective: The aim of the study is to explore the experiences of social support in treatment adherence of persons living with hypertension.

Method: This study utilized a qualitative research design ensuring methodological rigor and credibility. Semi-structured interviews with open-ended questions were conducted, audio recorded transcribed verbatim and analyzed using thematic content analysis.

Results: Participants primarily relied on companionship and emotional social support to maintain treatment adherence. While immediate blood pressure optimization was not achieved, improvements in overall health …

Exploring The Impact Of A Literacy-Based Service-Learning Project On Pre-Service Teachers, Shelly J. Landreth, Tara Wilson

Journal of Community Engagement and Higher Education

In this study, we describe a teacher educator’s first experience implementing a service-learning project in a children’s literature course in which pre-service teachers helped provide read-alouds for the local public library’s summer reading program. We sought to examine the impact the project had on the seven participants. Data was collected through reflective journals and an end-of-course debrief. Four themes were identified in the data: Initial Feelings, Preparation and Planning, Lessons Learned, and Barriers and Challenges.

Alma Link Resolver Referring Sources Report 2024-2025, Andrée J. Rathemacher

Technical Services Reports and Statistics

Statistics from 2024-2025 on the number of OpenURL requests made to the Alma link resolver for items held by the University of Rhode Island Libraries.

Information provided includes Source, Number of Requests, Number of Clicked Requests, % Clicks from Requests.

Du Rural Summit 2025: Full Conference Proceedings, 2025 Du Rural Summit

DU Rural Summit Conference Proceedings

Proceedings of the DU Rural Summit 2025, held June 27-27 in the Pueblo Convention Center. A gathering dedicated to addressing the unique opportunities and challenges facing rural schools and their communities.

Investigating Vacuum Insulator Flashover Resistance Of Rexolite And Acrylic Before And After Applying Novel Insulator Cleaning Techniques, Ritin Joseph

Electrical and Computer Engineering ETDs

Pulsed power involves accumulating large amounts of electrical energy and releasing it instantaneously. Large pulsed power accelerators use a vacuum insulator stack to facilitate power transfer from the liquid to vacuum section. Limiting the probability of surface flashover in this setting to acceptable levels improves machine longevity and prevents energy loss. Post-shot debris deposition requires a refurbishment process to prevent deterioration of dielectric performance, though the current technique of hand-sanding is long, labor-intensive, and pose serious health hazards. I have collected flashover data on frustrum-shaped Acrylic and C-Lec Rexolite® (cross-linked polystyrene) samples using a 500-kV, 20-ns risetime pulsed power test …

Individual Noise-Tolerance Profiles And Neural Signal-To-Noise Ratio: Insights Into Predicting Speech-In-Noise Performance And Noise-Reduction Outcomes, Subong Kim, Susan Arzac, Natalie Dokic, Jenn Donnelly, Nicole Genser, Kristen Nortwich, Alexis Rooney

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

Background/Objectives: Individuals with similar hearing sensitivity exhibit varying levels of tolerance to background noise, a trait tied to unique individual characteristics that affect their responsiveness to noise reduction (NR) processing in hearing aids. The present study aimed to capture such individual characteristics by employing electrophysiological measures and subjective noise-tolerance profiles, and both were analyzed in relation to speech-in-noise performance and NR outcomes. Methods: From a sample of 42 participants with normal hearing, the neural signal-to-noise ratio (SNR)—a cortical index comparing the amplitude ratio between auditory evoked responses to target speech onset versus noise onset—was calculated, and individual noise-tolerance profiles were …

Evaluating Nutrition, Exercise, And Education, On Mental Health And Quality Of Life In Menopause, Jill R. Stone

Walden Dissertations and Doctoral Studies

Physical inactivity, poor nutrition, and a lack of understanding of menopause adversely affect mental health and quality of life in women entering menopause. Metabolic changes during this period can lead to an increase in visceral fat, loss of muscle mass, depression, and anxiety. These metabolic changes are linked to a higher risk for cardiovascular disease, type two diabetes, and metabolic syndrome. This cross-sectional quantitative study, guided by the health belief model, explored the contribution of adopting specific nutrition strategies, exercise, and education in women during menopause transition to help manage mental health (as measured by depression and tension), and quality …

From Aortic Stenosis To Cardiomyopathy: The Hidden Impact Of Undiagnosed Acommissural Unicuspid Aortic Valve, Muhammad Sabri, Hamza Muhammadzai, Angad Bedi, Eddy Mizrahi, Matthew Collins

Abington Jefferson Health Papers

Unicuspid aortic valve (UAV) is a rare congenital anomaly, diagnosed in individuals aged 30 to 50. It is associated with aortic stenosis or aortic regurgitation, potentially leading to heart failure. We report a case of a 28-year-old male with an acommissural UAV, aortopathy, critical aortic stenosis, and heart failure with reduced ejection fraction, presenting with shortness of breath. This case is notable for late presentation of an acommissural UAV, which typically manifests in childhood.

Alma Link Resolver Subject Report 2024-2025, Andrée J. Rathemacher

Technical Services Reports and Statistics

Statistics for 2024-2025 on the number of OpenURL requests by Library of Congress classification code made to the Ex Libris Alma link resolver for items held by the University of Rhode Island Libraries.

Information provided includes Classification Code, Classifications, Number of Requests, Number of Clicked Requests, and % Clicks from Requests.

Alma Link Resolver Material Type Report 2024-2025, Andrée J. Rathemacher

Technical Services Reports and Statistics

Statistics for 2024-2025 on the number of OpenURL requests by material type made to the Ex Libris Alma link resolver for items held by the University of Rhode Island Libraries.

Information provided includes Material Type, Number of Requests, Number of Clicked Requests, and % Clicks from Requests.