Digital Commons Network^™

Genome-Wide Characterization Of Vdac Gene Family In Soybean (Glycine Max L.) And In Silico Expression Profiling In Response To Drought And Salt Stress, Muhammad Muneeb Ullah, Muqadas Aleem, Mudassar Muhammad Iqbal, Ainong Shi

Horticulture Faculty Publications and Presentations

Soybean (Glycine max L.) is grown worldwide to obtain edible oil, livestock feed, and biodiesel. However, drought and salt stress are becoming serious challenges to global soybean cultivation as they retard the growth of soybean plants and cause significant yield losses. Voltage-dependent anion-selective channel (VDAC) proteins are well-known for their role in drought and salt tolerance in crop plants. In this study, we identified 111 putative VDAC genes randomly distributed in genomes of 14 plant species, including cultivated soybean (Glycine max) and wild soybean (Glycine soja). The comparative phylogenetic studies classified these genes into six different clades and found the …

Systemic Carbonic Anhydrase Inhibitors In Common Ophthalmic Diseases: A Scoping Review From A Clinical Standpoint, Shahin Hallaj, Wesam S. Shalaby, Sapna Sinha, Jonathan S. Myers, Reza Razeghinejad

Wills Eye Hospital Papers

PURPOSE OF REVIEW: This paper provides a detailed overview of systemic carbonic anhydrase inhibitors (CAIs) and their application in managing ophthalmic conditions, including glaucoma, cystoid macular edema, and idiopathic intracranial hypertension. Despite their recognized clinical benefits, the potential for severe systemic adverse effects often discourages clinicians from prescribing these agents. By examining the pharmacology, pharmacokinetics, safety profile, and clinical indications of systemic CAIs, this review highlights strategies to mitigate treatment challenges, particularly in patients with comorbidities and complex medical backgrounds.

RECENT FINDINGS: New insights into the diverse roles and distribution of carbonic anhydrase (CA) isozymes have expanded our understanding of …

Ensuring Data Quality In Large International Development Projects: Tools, Strategies, And Lessons Learned, Jennifer Sdunzik, Ann M. Bessenbacher, Wilella D. Burgess, Asia M. Mohamud, Abdirisak Dalmar

Somalia Education Evaluation Publications

The success of development projects and evaluations hinges on having access to research protocols and methodologies that consider the needs and characteristics of stakeholders, subjects, and context while remaining rigorous and culturally sound. These efforts are often complicated by a dearth of tools that have been tested for validity and reliability in communities of interest and data collection environments that necessitate reliance on international and domestic partners with varying backgrounds to collect, process, and share data. Overcoming these challenges requires flexibility, intentionality, and continuous improvement across all partners. This article describes lessons learned from a mixed-methods longitudinal evaluation of an …

Str Analysis Performance Comparison For Two Capillary Electrophoresis Instruments: The Seqstudio And The 3500 Genetic Analyzers, Yana Leichyk

Student Theses

This study compares the performance of two capillary electrophoresis instruments—the SeqStudio™ Genetic Analyzer and the 3500™ Genetic Analyzer—for forensic short tandem repeat (STR) analysis. Using the GlobalFiler STR kit and certified reference material (SRM 2391d), five key performance metrics were evaluated: sizing precision, signal reproducibility, detection sensitivity, mixture resolution, and overload tolerance. STR profiles were generated from single-source and mixture samples with DNA inputs ranging from 500 pg to 15.6 pg. Both instruments met the < 0.15 bp sizing precision requirement for forensic casework. Signal reproducibility tests showed that the SeqStudio often produced higher average RFU values, but with greater variability, while the 3500 demonstrated more stable signal performance across days and samples. Mixture detection was effective on both platforms up to 1:10 ratios. Dropout of minor alleles began to appear at 1:20 ratios, especially in green and yellow dye channels, on both instruments. Sensitivity studies confirmed full profile recovery down to 62.5 pg, with increasing allelic and locus dropout at lower inputs. Enhanced injection voltage (1.5 kV) did not improve low-template performance. In overload testing (1–5 ng input), the 3500 maintained a consistent signal output, while the SeqStudio exhibited signal suppression at 5 ng, likely due to internal normalization. The SeqStudio exhibited better spectral overlap compensation, with fewer occurrences of spectral bleed-through artifacts. These findings support the use of both platforms in forensic casework, while emphasizing the importance of platform-specific calibration and analytical threshold settings for optimal performance.

‘They Say There’S More Equality…’: Women’S Perspectives On Progress And Setbacks In Gender Equality In Northern Iceland During Times Of Crisis, Marya Rozanova-Smith, Embla Eir Oddsdóttir, Andrey N. Petrov

Faculty Publications

Enabling gender equality through the empowerment of women to fully participate in modern society is one of the most critical steps toward sustainable development. However, recent UN reports indicate that the impacts of the COVID-19 pandemic have jeopardized the achievement of Sustainable Development Goal 5 by 2030 in many countries worldwide, including Iceland, which has consistently been ranked as a global leader in gender equality. The main objective of this qualitative study is to examine the gendered impacts of the COVID-19 pandemic by exploring women’s lived experiences during the crisis and its aftermath across the primary domains of gender equality—personal …

Feels Like Home, Qamar Bazar

Publications and Research

Feels Like Home is a personal poem about what home means and how it lives in our memories, culture, and the people we love, even when the physical place feels far or out of reach. With everything happening around the world, especially in places like Gaza and across Palestine, this poem is a reminder that home is something we carry in our language, our food, our traditions, and our stories. It explores themes of identity, belonging, and what it feels like to be rooted in a place you may not always get to return to. I wanted this piece to …

Food Noise: Definition, Measurement, And Future Research Directions, Emily J Dhurandhar, Kevin C Maki, Nikhil V Dhurandhar, Theodore K Kyle, Sydney Yurkow, Misty A W Hawkins, Jon Agley, Emily H Ho, Lawrence J Cheskin, Thorkild I A Sørensen, Xi Rita Wang, David B Allison

Children’s Nutrition Research Center Staff Publications

The term food noise has been recently popularized by individuals managing their weight or adhering to specific diets for health reasons. Anecdotal evidence from patients and clinical observations suggests that food noise involves constant preoccupation with food-related decisions-such as which foods to eat, caloric intake, macronutrient balance, and meal timing-which can become intrusive and unpleasant. Food noise also appears to affect cognitive burden and quality of life, and is being cited as one reason weight-loss attempts fail. The increase in public discourse about food noise has highlighted its potential significance, yet a formal clinical definition and method of measurement of …

The Storm They Didn’T See Coming, Qamar Bazar

Publications and Research

The Storm They Didn’t See Coming is a personal story about what it feels like to chase success and still feel like it’s not enough. I discuss the pressure I put on myself, how difficult it is to slow down, and the fear of falling behind. It’s about trying to be proud of where I am while still wanting more, and learning that it’s okay to not have everything figured out. This piece is for anyone who's ever felt like they had to keep proving themselves just to feel worthy.

Perceived Experiences Of Native American Men During Incarceration In Tribal Jail, Stacy Marie Becker

Walden Dissertations and Doctoral Studies

The subject of this dissertation is the Perceived Experiences of Native American Men during Incarceration in Tribal Jail. The reason for this research is to determine what practices are rehabilitative and what practices are detrimental to this population. This is important to learn so that criminal justice professionals will be able to consider possible changes that can be made to make recidivism less likely among this population while increasing practices that are conducive to rehabilitation. This work was researched using the Indigenous Standpoint Theory which is meant to reflect the experiences and views of the research participants without analysis through …

Opposing Roles For Myeloid And Smooth Muscle Cell Sting In Pulmonary Hypertension, Ann T Pham, Shiza Virk, Aline C Oliveira, Matthew D Alves, Chunhua Fu, Yutao Zhang, Jimena Alvarez-Castanon, Brian B Lee, Keira L Lee, Radwan Mashina, Katherine E Ray, Patrick Donabedian, Elnaz Ebrahimi, Harsh Patel, Reeha Patel, Duncan Lewis, Zhiguang Huo, Harry Karmouty-Quintana, Li Chen, Lei Jin, Andrew J Bryant

Faculty, Staff and Student Publications

There is an emerging role for stimulator of interferon genes (STING) signaling in pulmonary hypertension (PH) development. Related to this, prior research has demonstrated the relevance of immune checkpoint protein programmed death ligand 1 (PD-L1) expression by immunoregulatory myeloid cells in PH. However, there remains a need to elucidate the cell-specific role of STING expression, and the STING/PD-L1 signaling axis in PH, before readily available disease-modifying therapies can be applied for patients with the disease. Here, through generation of bone marrow chimeric mice, we show that STING-/- mice receiving WT bone marrow were protected against PH secondary to chronic hypoxia. …

Exploring Sub-Protocols For Spectrum Cooperation And Transparency, Ashton Palacios

Theses and Dissertations

With the proliferation of terrestrial and space-based wireless radio frequency transmitters and receivers in recent years, there is a greater need for spectrum cooperation and transparency. Spectrum is a limited resource that is shared between all wireless devices, both active and passive. The spectrum needs of today and tomorrow demand new techniques to enable cooperation and device transparency. This dissertation explores an innovative field, wireless sub-protocols, that provides novel software solutions for spectrum cooperation and transparency. The first application is radio astronomy. Radio astronomy deploys highly sensitive, passive RF receivers to capture faint signals from distant celestial bodies. Because passive …

Mechanism Of Ph-Sensitive Amphiphilic Endosomal Escape Of Ionizable Lipid Nanoparticles For Cytosolic Nucleic Acid Delivery, Zheng Rong Lu, Da Sun

Faculty Scholarship

Lipid nanoparticles (LNPs) are among the most successful classes of nonviral delivery systems for nucleic acid-based therapeutics in treating human diseases. One of the key challenges in achieving efficient cytosolic delivery of nucleic acids is overcoming endosomal entrapment within cells. Conventional lipid bilayer-forming cationic and amino lipids mediate endosomal escape via the mechanism of lamellar-to-inverted hexagonal phase transition, resulting in suboptimal cytosolic cargo delivery. pH-sensitive amphiphilic cell membrane disruption and endosomal escape have emerged as a strategy for designing protonatable or ionizable lipids, especially nonlamellar lipids, for efficient cytosolic nucleic acid delivery. Nonlamellar amino lipids possess a large wedge-shaped tail …

Beliefs About The Causes And Treatment Of Common Mental Illnesses And Suicidality In Rural Uganda, Yang Jae Lee, Rita Mbabazi, Ondine Jevremov, Shakira Nakaweesi, Ella Brodey, Jason Wykoff, Roshan Sivakumar, Rauben Kazungu, Ibrahim Ssekalo, Robert Rosenheck, Alexander C Tsai

2020-Current year OA Pubs

BACKGROUND: Mental illnesses constitute a large and escalating portion of the global burden of disease, particularly in low- and middle-income countries like Uganda. Understanding community perceptions towards mental illness is crucial for developing effective interventions.

AIMS: To explore beliefs about the perceived causes and treatment of common mental illnesses (depression, anxiety, alcohol use disorder) and suicidality in rural eastern Uganda.

METHOD: Qualitative study using 31 in-depth interviews and 4 focus group discussions with healthcare workers, community health workers, community leaders and general community members in Buyende District, Uganda. Vignettes were used to depict mental illnesses to elicit perceptions, and data …

Ehealth Technologies In Transitional Care Interventions For Stroke Survivors And Caregivers: A Scoping Review, Orachorn Lumprom, Charuwan Kritpracha, Cansel Kocakabak, Jos M. Latour

School of Nursing and Midwifery

The high rate of stroke disability necessitates extensive care during transitions between hospitals and homes. While many transitional care interventions have emerged, no explicit evidence illustrates the details of those combining or integrating eHealth. The aim of this scoping review was to comprehensively map the literature on eHealth technologies within transitional care interventions for stroke survivors and their caregivers. Studies were included if they focused on transitional care interventions that combined or integrated eHealth technologies for adult and elderly survivors of post-hyperacute stroke, as well as for caregivers aged 18 years and older. A systematic search was conducted from inception …

On Two-Generator Subgroups Of Mapping Torus Groups, Naomi Andrew, Edgar Bering Iv, Ilya Kapovich, Stefano Vidussi, Peter Shalen

Faculty Research, Scholarly, and Creative Activity

We prove that if (Formula presented.) is the mapping torus group of an injective endomorphism (Formula presented.) of a free group (Formula presented.) (of possibly infinite rank), then every two-generator subgroup (Formula presented.) of (Formula presented.) is either free or a (finitary) sub-mapping torus. As an application we show that if (Formula presented.) is a fully irreducible atoroidal automorphism, then every two-generator subgroup of (Formula presented.) is either free or has finite index in (Formula presented.).

The Co-Occurrence Of Autism Spectrum Disorder And Aarskog-Scott Syndrome In An Accomplished Young Man, Raisa S Romanova, Oksana I Talantseva, Katerina V Lind, Victoria A Manasevich, Julia E Kuznetsova, Elena L Grigorenko

Faculty, Staff and Students Publications

Objectives/Background: Aarskog-Scott syndrome (AAS), also known as faciogenital dysplasia, is a rare X-linked genetic disorder primarily characterized by its diverse physical manifestations. Previous evidence suggests a potential association between AAS and neurodevelopmental disorders, including autism spectrum disorder (ASD).

Methods: This case study presents a male adolescent with ASD and a novel genetic variant in FGD1 underlying AAS. We conducted comprehensive clinical, genetic, and behavioral assessments to characterize the neurodevelopmental presentation. Moreover, we examined the existing literature on AAS and comorbid neurodevelopmental disorders.

Results: The patient demonstrated features consistent with both AAS and ASD, presenting with characteristic physical features of AAS …

Infantile Pyknocytosis Revisited: Possible Familial Trend In A Study Of 9 Patients, Aileen Y Hu, Amy M Coffey, Jyotinder N Punia, Andrea N Marcogliese, Choladda V Curry, M Tarek Elghetany

Faculty, Staff and Students Publications

Context.—: Infantile pyknocytosis (IP) is an uncommon cause of transient neonatal hemolytic anemia and hyperbilirubinemia occurring in approximately 10% of cases of unexplained neonatal hemolytic anemia.

Objective.—: To study cases of IP with focus on long-term follow-up, perinatal events, and family history.

Design.—: Cases were prospectively identified during review of peripheral blood smears for neonatal hyperbilirubinemia during an 11-year period. Clinical and laboratory parameters, follow-up data, and family history were recorded.

Results.—: Nine cases of IP were identified from the morphologic recognition of pyknocytes and clinical and laboratory evidence of hemolysis, and included 6 males and 3 females. Age at …

Younger Haplo-Donors Improve Older Patient Survival Outcomes, Ahmad Ghorab, Leo Luznik

Faculty, Staff and Students Publications

No abstract provided.

Psilocybin Treatment Extends Cellular Lifespan And Improves Survival Of Aged Mice, Kosuke Kato, Jennifer M Kleinhenz, Yoon-Joo Shin, Cristian Coarfa, Ali J Zarrabi, Louise Hecker

Faculty, Staff and Students Publications

Psilocybin, the naturally occurring psychedelic compound produced by hallucinogenic mushrooms, has received attention due to considerable clinical evidence for its therapeutic potential to treat various psychiatric and neurodegenerative indications. However, the underlying molecular mechanisms remain enigmatic, and few studies have explored its systemic impacts. We provide the first experimental evidence that psilocin (the active metabolite of psilocybin) treatment extends cellular lifespan and psilocybin treatment promotes increased longevity in aged mice, suggesting that psilocybin may be a potent geroprotective agent.

The Benefits Of Exercise Training In Combination With Weight Loss Therapies, Bryan C Jiang, Dennis T Villareal

Faculty, Staff and Students Publications

The primary treatment for obesity involves calorie restriction (CR) to promote dietary weight loss achieved through interventions including behavioral modification, bariatric surgery, and antiobesity medications. In adults with obesity, CR-induced weight loss enhances physical function and improves quality of life, while also reducing the burden of various obesity-related chronic conditions, including hypertension, diabetes, obstructive sleep apnea, and atherosclerotic heart disease. However, it is also associated with a decline in lean mass and bone mineral density, which increases the risk of sarcopenia and osteoporosis. When performed alongside CR, progressive resistance training (RT) attenuates this loss of lean mass and bone mass, …

High-Affinity Cd16a Polymorphism Associated With Reduced Risk Ofsevere Covid-19, Anita E Qualls, Tasha Tsao, Irene Lui, Shion A Lim, Yapeng Su, Ernie Chen, Dylan Duchen, Holden T Maecker, Seunghee Kim-Schulze, Ruth R Montgomery, Florian Krammer, Charles R Langelier, Ofer Levy, Lindsey R Baden, Esther Melamed, Lauren Ir Ehrlich, Grace A Mccomsey, Rafick P Sekaly, Charles B Cairns, Elias K Haddad, Albert C Shaw, David A Hafler, David B Corry, Farrah Kheradmand, Mark A Atkinson, Scott C Brakenridge, Nelson I Agudelo Higuita, Jordan P Metcalf, Catherine L Hough, William B Messer, Bali Pulendran, Kari C Nadeau, Mark M Davis, Ana Fernandez-Sesma, Viviana Simon, Monica Kraft, Christian Bime, Carolyn S Calfee, David J Erle, Joanna Schaenmann, Al Ozonoff, Bjoern Peters, Steven H Kleinstein, Alison D Augustine, Joann Diray-Arce, Patrice M Becker, Nadine Rouphael, Impacc Network, Jason D Goldman, Daniel R Calabrese, James R Heath, James A Wells, Elaine F Reed, Lewis L Lanier, Harry Pickering, Oscar A Aguilar

Faculty, Staff and Students Publications

CD16A is an activating Fc receptor on NK cells that mediates antibody-dependent cellular cytotoxicity (ADCC), a key mechanism in antiviral immunity. However, the role of NK cell-mediated ADCC in SARS-CoV-2 infection remains unclear, particularly whether it limits viral spread and disease severity or contributes to the immunopathogenesis of COVID-19. We hypothesized that the high-affinity CD16AV176 polymorphism influences these outcomes. Using an in vitro reporter system, we demonstrated that CD16AV176 is a more potent and sensitive activator than the common CD16AF176 allele. To assess its clinical relevance, we analyzed 1,027 patients hospitalized with COVID-19 from the Immunophenotyping Assessment in a COVID-19 …

Mediating The Exquisite: Aesthetic Affordances Of The Network Arts, Seth Adams

Journal of Network Music and Arts

This paper argues that the Network Arts afford uniquely nuanced aesthetic interactions among humans and between humans and machines. After defining these moments under a new concept I call exquisite musicking, I investigate how distributed networks of human and nonhuman actors create experiences that challenge or complicate traditional notions of agency, ensemble, aesthetics, and synchrony. Using Actor-Network Theory as a lens of inquiry, I explore the exquisite affordances of network-based musicking, discussing how pitch, timbre, and texture are co-created in networked performances. I also examine how exquisite musicking could serve as a fruitful concept in music education, particularly in pedagogical …

The Devil’S In The Details: Opposition To Demonology In Early Modern Europe, Abigail Pickard

The Purdue Historian

Common assumptions that believers of witchcraft in the early modern period were uneducated fanatics overgeneralize the complex interplay of early modern science and theology. The study of demons, known as demonology, was considered a science. It was a respected field that was studied and debated. Theologians scrutinized, defended, and revised demonological theories. Thinkers turned over foundational concepts and split hairs over the fine details of theology. Since educated scholars were considered authorities on demonology, they repeatedly wrote, talked, and theorized about the topic in a similar fashion to other ideologies of the early modern era. Due to this, authors of …

Xyy: Why? Science For The People And The Xyy Controversy, Fern Rice

The Purdue Historian

The mid-20th century saw a boom of scientific discoveries in genetics as people sought to understand the American political landscape through genomes. The desire to understand criminality through genetics rose as counterculture surged. The genetic defect known as “XYY syndrome” became connected to criminality through biased medical studies and sensationalized criminal cases worldwide. When the National Institute of Mental Health began to fund studies attempting to prove a link between XYY syndrome and criminality, organizations concerned with scientific justice took notice. The leftist organization Science for the People campaigned against an XYY study in Boston, deeming it unethical and biologically …

Interplanetary Colonization And Multi-Agent Systems Systematized Literature Review Methodology, Ava Neubert

Discovery Day - Daytona Beach

The vision of colonizing Mars presents significant technological and logistical challenges that require advanced autonomous systems. Multi-agent systems, where multiple intelligent agents cooperate to solve complex problems, are as a promising approach to manage and optimize tasks involved in planetary colonization. However, it remains unclear which areas of general multi-agent systems research have been specifically considered or developed for Mars colonization efforts. Addressing this gap is crucial to guide the development of new multi-agent systems strategies in preparation for future missions to Mars. In response, we are conducting a systematic literature review to answer the research question, "What is the …

Visionarium, July 2025, Full Issue

International Journal of Emerging and Disruptive Innovation in Education : VISIONARIUM

No abstract provided.

Artificial Intelligence And Transformative Curricula Practices In Africa For Educational Development, Ibiwumi Abiodun Alade, P Mthetwa

International Journal of Emerging and Disruptive Innovation in Education : VISIONARIUM

Industrial revolutions in the world have orchestrated numerous innovations, and the impact on educational landscape in different countries do not leave the society to remain static. However, with the emergence of Artificial Intelligence (AI) in the fourth era of industrial revolution, the structural shift and the effect it might significantly cause in transformative educational and curricula practices deserve attention. This paper therefore, explored “artificial intelligence and transformative curricula practices in Africa for educational development” In the paper, a review of the transformative era of the Four Industrial Revolutions (4IR) within which artificial intelligence emerges has been explored, Also, an …

Writing As Curation: Empowering Authorial Agency In Ai-Assisted Composition Through Style Prompting And Quotation Glosses, Daniel Plate

International Journal of Emerging and Disruptive Innovation in Education : VISIONARIUM

As artificial intelligence writing tools become increasingly prevalent in educational settings, students often report feeling alienated from AI-generated content, describing it as lacking their "authentic voice." This article presents a pedagogical approach that addresses this challenge by repositioning students as curators of their authorial identities rather than passive consumers of AI-generated text. Through a dual curation methodology combining quotation glosses with style prompting, students develop multiple authorial voices for different rhetorical situations while maintaining agency over their writing process. The approach builds on classical rhetorical traditions while leveraging contemporary AI capabilities, creating a framework where students collaborate with AI tools …

Community-Based Art Education In Early Field Experiences: Facilitating Opportunities For Preservice Art Education Students To Support Students With Disabilities, Kristin Vanderlip Taylor

Journal of Community Engagement and Higher Education

Preservice art education students are often required to engage in Early Field Experience (EFE) observation hours before entering a credential program. Community-based art education (CBAE) projects may provide them with EFE opportunities to apply what they are learning in art education environments beyond the traditional classroom. This article describes one such CBAE project with a nonprofit organization providing arts instruction to students with different abilities and needs, primarily those with autism spectrum disorder (ASD).

The State Of The Field On Popular Culture Themed (Pct) Courses: Introducing The Journal Of Thematic Instruction, Kathy R. Doody Ph.D., Pamela Schuetze Ph.D., Jill M. Swirsky Ph.D.

Journal of Thematic Instruction

As universities adapt to meet evolving student needs, popular culture themed (PCT) courses have emerged as an innovative approach that integrates media with academic theory to foster engagement, critical thinking, and interdisciplinary connections. PCTs use popular culture themes that are not directly related to the course content to teach the course content. Despite their growing use across diverse disciplines, from STEM to the humanities, there is a lack of cohesive understanding, consistent terminology, and empirical research on the impacts of PCT courses in higher education.

This paper reviews existing literature on PCT courses organized by discipline, highlighting representative pedagogical strategies, …