Digital Commons Network^™

Gene Expression In Tumor And Adjacent Normal Tissues In Lung Adenocarcinoma Subtypes, Olga Y Gorlova, Ivan P Gorlov, R Taylor Ripley, Chao Cheng, Yafang Li, Bo Peng, Yanhong Liu, Hee-Jin Jang, Sung Wook Kang, Claire Lee, Priyanka Ranchod, Bryan M Burt, Hyun-Sung Lee, Christopher I Amos

Faculty, Staff and Students Publications

Background: Lung adenocarcinoma (LUAD) has several histologically distinct subtypes that differ by a number of clinical features including patient survival. Molecular mechanisms underlying histological and clinical differences between subtypes remain poorly understood.

Methods: We conducted a comparative analyses of gene expression in acinar, lepidic, papillary and solid subtypes, as well as mucinous adenocarcinoma. We used a novel, more efficient approach to identify subtype-specific genes. We compared the mean gene expression level separately for tumors and adjacent normal tissue with pure or a highly represented (≥ 75%) subtype of interest to the mean expression in tumors where the subtype of interest …

Spatial Proximity Of Immune Cell Pairs To Cancer Cells In The Tumor Microenvironment As Biomarkers For Patient Stratification, Jian-Rong Li, Xingxin Pan, Yupei Lin, Yanding Zhao, Yanhong Liu, Yong Li, Christopher I Amos, Chao Cheng

Faculty, Staff and Students Publications

Background/objectives: The tumor microenvironment (TME) plays a critical role in cancer progression by shaping immune responses and influencing patient outcomes. We hypothesized that the relative proximity of specific immune cell pairs to cancer cells within the TME could help predict their pro- or anti-tumor functions and reflect clinically relevant immune dynamics.

Methods: We analyzed imaging mass cytometry (IMC) data from lung adenocarcinoma (LUAD) and triple-negative breast cancer (TNBC) cohorts. For each immune cell pair, we calculated a relative distance (RD) score, which quantifies the spatial difference in proximity to cancer cells. We assessed the prognostic and predictive significance of these …

The Feasibility Of Passively Tracking Children’S Tv Viewing And Mobile Device Use In Naturalistic Settings, Teresia M O'Connor, Tatyana Garza, Uzair Alam, Anil Kumar Vadathya, Jennette P Moreno, Alicia Beltran, Samah Haidar, Nimah Haidar, Sheryl O Hughes, Debbe Thompson, Salma M A Musaad, Tom Baranowski, Jason A Mendoza, Joseph Young, Akane Sano, Ashok Veeraraghavan

Faculty, Staff and Students Publications

Research on children's technology and digital media (TDM) is hampered by a lack of robust approaches for assessing TDM use. This study assessed the feasibility of passively measuring children's TV screens and mobile devices (TDM) in a naturalistic setting. In the three-day feasibility study, FLASH-TV was set up on one to two TVs the child (5-12 year olds) typically used in the home (n=20). Children's mobile device use was assessed with either the Chronicle App or ScreenTime screenshots. Parents completed three TDM diaries. An exit interview with the parent explored their perceptions of the assessments and the child's TDM use …

Exogenous Arginine Differentially Regulates Inflammatory Cytokine And Inducible Nitric Oxide Synthase Expression In Macrophages, Kelsey Stayer, Saliha Pathan, Aalekhya Biswas, Huiqiao Li, Yi Zhu, Fong Wilson Lam, Juan Marini, Sundararajah Thevananther

Faculty, Staff and Students Publications

Immune dysfunction and late mortality from multiorgan failure are hallmarks of severe sepsis. Arginine, a semi-essential amino acid important for protein synthesis, immune response, and circulatory regulation, is deficient in sepsis. However, arginine supplementation in sepsis remains controversial due to the potential to upregulate inducible nitric oxide synthase (iNOS)-mediated excessive nitric oxide (NO) generation in macrophages, leading to vasodilation and hemodynamic catastrophe. Citrulline supplementation has been considered an alternative to replenishing arginine via de novo synthesis, orchestrated by argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase (ASL). However, the functional relevance of the ASS1-ASL pathway in macrophages after endotoxin stimulation is …

Beowulf And Théoden: Differing Teaching Methods Of Hrothgar And Gandalf, Ali Mirzabayati

Journal of Tolkien Research

Most studies on the character of Théoden in The Lord of the Rings center on Germanic heroic themes like courage and oath-keeping, often emphasizing his renewal by Gandalf at Meduseld and his death at the Battle of Pelennor Fields. This perspective overlooks Théoden's growth in wisdom and hope between these events. During this period, Théoden learns about the various forces in Middle-earth and contemplates his role in the broader world, leading to a profound sense of humility. Building on Tolkien's inspiration from Beowulf, this paper compares Théoden and Beowulf to explore their learning processes and heroic outcomes. This comparison …

Impact Of Primary Care Healthcare Providers Patient Electronic Medical Records Completion Rates Using Speech Recognition Dictation, Pepper Losely

Student Scholarly Projects

Practice Problem: Completion of electronic medical records (EMRs) is an ongoing problem for providers, facilities, and insurance reimbursement. Current completion of EMRs lack standardized processes to make EMRs completion easier for providers with their busy workday and allow optimal time for patient care.

PICOT: For healthcare providers at primary clinics (P) will implementing speech recognition dictation (SRD) for data entry into the electronic medical records (EMRs) (I) compared to the current practice of manually typing all data causing long medical record turnaround times (c) improve medical record completion within 30 days (O) over 10-weeks (T).

Evidence: Evidence that was …

Facilitating Novice Learning In Visual Search: Baseline-Dependent Effects Of Transcranial Electrical Stimulation Over The Right Inferior Frontal Gyrus, Bradley M. Robert

Psychology ETDs

Transcranial electrical stimulation (tES) has shown potential to modulate attention and enhance learning, yet its effects in applied, real-world contexts, remains underexplored. This study investigated the impact of transcranial direct current stimulation (tDCS) and high-frequency transcranial random noise stimulation (hf-tRNS with DC offset) on performance in a synthetic aperture radar (SAR) visual search task requiring both target identification and change detection. Participants (N = 63) were randomly assigned to tDCS, hf-tRNS, or sham conditions, with stimulation applied to the right inferior frontal gyrus (F10) during the training phase. Accuracy served as the primary outcome, with supplementary EEG and eye-tracking data …

Alaska’S Type M Teacher Workforce: An Overview, Noah Burke, Dayna Jean Defeo, Douglas Cost, Matthew Berman, Olga Skinner

CAEPR Reports

This policy brief gives an overview of Alaska’s Type M teacher workforce with information about the demographics, teaching assignments, and retention rates of Type M teachers. The paper discusses the state policies around teacher certification, and considers the implications and limitations of the Type M certificate in the context of teacher retention and representation.

Eloq: Resources For Enhancing Llm Detection Of Out-Of-Scope Questions, Zhiyuan Peng, Jinming Nian, Alexandre Evfimievski, Yi Fang

Computer Science and Engineering

Retrieval-augmented generation (RAG) has become integral to large language models (LLMs), particularly for conversational AI systems where user questions may reference knowledge beyond the LLMs' training cutoff. However, many natural user questions lack well-defined answers, either due to limited domain knowledge or because the retrieval system returns documents that are relevant in appearance but uninformative in content. In such cases, LLMs often produce hallucinated answers without flagging them. While recent work has largely focused on questions with false premises, we study out-of-scope questions, where the retrieved document appears semantically similar to the question but lacks the necessary information to answer …

Characterization Of Dna Background On Duct Tape Stored In Domestic Environments, Elaan A. Lukasiewicz

Student Theses

With lower detection limits for forensic DNA analysis, it is important to have a better understanding of background DNA levels unrelated to the crime to facilitate accurate data interpretation. Duct tape is used in crimes, e.g. to bind victims and seal drug packaging, and may be tested for DNA. To determine DNA background levels, twelve volunteers were recruited to donate a used roll of duct tape from their home. The duct tape was divided into three areas: inside, outside, and sides of the roll, and swabbed for DNA. The average concentration of DNA was determined for the inside (0.0723 ng/µL …

Qualitative Research Methods In English Medium Instruction For Emerging Researchers: A Book Review, Dewi Bernike Tampubolon

The Qualitative Report

This review discusses the book Qualitative Research Methods in English Medium Instruction for Emerging Researchers, edited by Samantha M. Curle and Jack K. H. Pun, published in 2023. In this review, I provide a summary of the book's content as well as an overview of each chapter that includes theory and case studies from different countries. I also discuss the structure and organization of the book, including its strengths and weaknesses. The review concludes with an evaluation that the book is a very useful resource and practical guide for early career researchers, supervisors, EMI practitioners and scholars in the …

Qder: Query-Specific Document And Entity Representations For Multi-Vector Document Re-Ranking, Shubham Chatterjee, Jeff Dalton

Computer Science Faculty Research & Creative Works

Neural IR has advanced through two distinct paths: entity-oriented approaches leveraging knowledge graphs and multi-vector models capturing fine-grained semantics. We introduce QDER, a neural re-ranking model that unifies these approaches by integrating knowledge graph semantics into a multi-vector model. QDER's key innovation lies in its modeling of query-document relationships: rather than computing similarity scores on aggregated embeddings, we maintain individual token and entity representations throughout the ranking process, performing aggregation only at the final scoring stage-an approach we call "late aggregation." We first transform these fine-grained representations through learned attention patterns, then apply carefully chosen mathematical operations for precise matches. …

Mbiochemical Identification And Clinical Description Of Edetomidine Exposure In People Who Use Fentanyl In Philadelphia, Pa, Phil Durney, Jennifer L. Kahoud, Tareva Warrick-Stone, Maeve Montesi, Meg Carter, Sabrina Butt, Alberto Martinez Mencia, Louisa Omoregie, Monali Shah, Mariah Bloomfield, Nicholas Tomasko, Rebecca C. Jaffe, Allison Herens, Warren R. Korn, Karen Alexander, Douglas F. Stickle, Dennis Goodstein, Lara Weinstein, Kory S. London

Department of Emergency Medicine Faculty Papers

Medetomidine, a veterinary α2-adrenergic agonist, has recently emerged as an adulterant in the non-medical opioid supply, yet human exposure has remained poorly characterized. We conducted a pragmatic retrospective cohort analysis utilizing chart review and liquid chromatography-tandem mass spectrometry (LC-MS/MS) toxicology testing on available urine samples from patients presenting to two hospitals in Philadelphia, PA, who fit two clinical phenotypes, intoxication or withdrawal. Samples also underwent glucuronidase pre-treatment to assess impact on the yield of medetomidine and xylazine metabolite detection. Testing identified universal exposure to medetomidine (58/58 samples) via the 3-hydroxy-medetomidine (3-OH-M) metabolite, post glucuronidase treatment and variable xylazine exposure (40/58 …

Ovochymase 2 Is A Key Regulatory Factor Modulating Proteolytic Pathways And Sperm Maturation In The Mammalian Epididymis, Katarzyna Kent, Kaori Nozawa, Antrix Jain, Anna Malovannaya, Thomas X Garcia, Martin M Matzuk

Faculty, Staff and Students Publications

Spermatozoa acquire fertilizing competence during epididymal transit through proteolytic, chaperone-mediated, and post-translational modifications. Ovochymase 2, an epididymis-specific trypsin-like serine protease, has emerged as a central regulator of this maturation process. Here, we integrate targeted gene disruption, comprehensive proteomic profiling, and affinity-based proteome enrichment to delineate how Ovochymase 2 influences sperm functionality. Deletion of Ovochymase 2 disrupts the proteome of epididymal sperm, resulting in diminished levels of core fertility-related factors-including a disintegrin and metalloprotease domain 3, β-defensins, and protease-inhibitor complexes-while inducing compensatory upregulation of alternate proteases and chaperones. Interaction assays confirm direct or indirect associations between Ovochymase 2 and sperm surface …

A Mouse Model Engineered To Spatiotemporally Control Cre Expression In Progesterone Receptor Positive Cells†, Elvis Quiroz, Ryan M Marquardt, Shu-Yun Li, Artiom Gruzdev, David Cunefare, Charan Ganta, San-Pin Wu, John P Lydon, Francesco J Demayo

Faculty, Staff and Students Publications

The Cre/loxP system is widely used for site-specific genetic manipulation in mice. The PgrCre mouse model, where Cre recombinase is driven by the progesterone receptor promoter, is commonly used for gene ablation in Pgr-positive uterine cells. However, the PgrCre is active in the neonatal uterus and does not allow temporal control. To enhance the functionality of the PgrCre mouse, we generated and characterized an inducible PgriCreERT2 mouse, in which iCreERT2 is inserted downstream of the endogenous Pgr promoter. PgriCreERT2 mice crossed with Rosa26-CAG-LSL-Sun1-sfGFP-myc reporter mice demonstrated tamoxifen-dependent recombination in uterine stromal fibroblasts and a subset of epithelial cells. Tamoxifen-induced ablation …

The Cortical Motor Map For The Extensor Digitorum Communis Muscle Fails To Increase In Treatment-Related Clinically Significant Upper Limb Post-Stroke Recovery, Tomoko Kitago, Joshua Silverstein, Michael B. Gerber, Charlene Thomas, Linda M. Gerber, Gary W. Thickbroom, Dylan J. Edwards

Moss-Magee Rehabilitation Papers

Objectives: Cortical reorganization has been proposed as a mechanism for motor recovery of the upper limb. The objective of this study was to determine if intervention-related clinical improvement in post-stroke hemiparesis is associated with enlarged motor cortex representation. Methods: Data were analyzed from a single site subset of the NICHE trial. Clinical assessments of upper limb movement (Fugl-Meyer Upper Extremity Motor Assessment, FM-UE, Action Research Arm Test, ARAT, and Wolf Motor Function Test, WMFT) and transcranial magnetic stimulation (TMS) motor mapping of the extensor digitorum communis (EDC) muscle were performed in 23 participants (3–12 months post-stroke, 10 female, 40–88 yrs) …

Pd-Based Hydrogen Separation Membranes Synthesized Via A Liquid-Phase Route, Chase W. Thompson

Chemical and Biological Engineering ETDs

Palladium (Pd) membranes have gained significant attention for their ability to selectively separate hydrogen, a critical process for clean energy applications such as fuel cells and hydrogen storage. However, challenges such as grain growth, sintering, hydrogen embrittlement, and film uniformity limit their scalability and long-term stability. This thesis focuses on the controlled synthesis, deposition, and stability of Pd nanoparticles to optimize membrane performance for hydrogen separation. This work investigates solution-phase synthesis of Pd nanoparticles, focusing on temperature, precursor concentration, and solvent composition as key variables influencing particle growth and dispersion. Pd membranes were fabricated using nanoparticle deposition onto porous supports, …

Cultural Humility, Holistic Admission Review, And Multicultural Experiences Among Newly Admitted Nursing Students, Janna Michelle Hackett

Nursing ETDs

This study explored the impact of Holistic Admissions Review (HAR) on demographic characteristics, multicultural experiences, and cultural humility (CH) levels among newly admitted pre-licensure nursing students. Fostering CH and diversity among healthcare providers may help reduce health disparities. Traditional admissions methods may not identify candidates with traits supporting CH development, whereas HAR considers diverse backgrounds and experiences. Two groups were surveyed: one admitted through HAR and the other through traditional methods. No significant differences in CH scores were found, but significant differences were found in age, living abroad, and volunteering with diverse populations. Students admitted through HAR were younger and …

Relationship Between Mindfulness And Eudaimonic Well-Being In A Thai Adult Sample: Roles Of Hope And Meaning In Life, Somboon Jarukasemthawee, David B. Feldman, Kullaya Pisitsungkagarn, David C. Wang

Counseling Psychology

We examine the relationship between mindfulness and eudaimonic well-being in Thai adults, a population largely overlooked in mindfulness research despite the strong influence of Buddhism within this culture. Specifically, we hypothesized that hope and meaning will account for variance in this relationship. Utilizing self-report measures for mindfulness, hope, meaning in life, and eudaimonic well-being, findings from a sample of 269 Thai adults revealed significant positive correlations between all of these constructs and eudaimonic well-being. Regression analyses also indicated that hope and meaning in life accounted for statistically significant variance in the relationship between mindfulness and eudaimonic well-being and that mindfulness, …

Book Review: Lessons From History: Emerging And Non-Western Concepts Of Leadership And Spirituality, Elizabeth Gingerich

The Journal of Values-Based Leadership

No abstract provided.

The Enduring Flame: Churchill’S Leadership Qualities And Their Relevance Today, Emilio F. Iodice

The Journal of Values-Based Leadership

No abstract provided.

Perspective - Leadership And Management, Eric Silfen

The Journal of Values-Based Leadership

Why do we care?

Leadership is a word on everyone’s tongue. A hackneyed word. A much bantered about word. A word that engenders “good feeling”. A word that denotes reaching the pinnacle. A word akin to soaring heights. An Icarus word. A word that implies others will follow. A Pied Piper word.

But what is our view of leadership from below? What inspires us to be led? What makes us strive for this pinnacle? And why do we care? And why do we ignore that the leader might not be one of us?

In this article, we explore the origin …

Summer/Fall 2025

The Journal of Values-Based Leadership

No abstract provided.

Censorship In The Media

Communication Research Trends

The principle of freedom of expression in the press, book publishing and broadcasting has been one of the hard-won battles in human history. Without this freedom, a democratic society,, could not exist. Yet every community and nation has to make painful decisions about what will, or will not be communicated. Libel and privacy are obvious examples. Otherwise our societies would virtually disintegrate. Does freedom of speech have limits? If so, how do we decide on these limits?

New forms of censorship are always creeping in. Currently it is insinuated that consumer protection groups such as Action for Children's Television in …

Television's Influence On Cultures

Communication Research Trends

It is widely assumed by the public, broadcasters and some communication researchers that television has caused major shifts in contemporary world view and values. McLuhan introduced the notion that the form of the medium itself- the simultaneous sound and vision - has brought about a new intuitive, holistic pattern of thinking. For McLuhan, the generation gap is the product of a television generation. Gerbner sees television as the central cultural arm of American society. Like a religion, it is the chief source of repetitive and ritualised symbol systems cultivating the consciousness of mass publics.

Others think that the process is …

The Language Of Film And Television

Communication Research Trends

An increasing number of people receive most of their news, entertainment and even religious inspiration through the visual media of film, television or illustrated magazines. We all "watch" television.James Monaco notes that some cats watch television attentively! But how well do we grasp the specific language of the visual media?

In countries such as the U.S., there is evidence that the post-1950 generation that has grown up with television has a pattern of thinking more attuned to the visual than to print media. Yet, some cross-cultural studies suggest that many American children, for all of the long hours of TV …

The Intersection Between Child Marriage And Climate Change: An Example Of Malawi, Musu Bakoto Sawo

Journal of African Policy Studies

Child marriage affects 39,000 girls daily, totaling 650 million women married before age eighteen globally. While driven by poverty, tradition, and limited education, climate change is emerging as a significant new factor, particularly in developing nations such as Malawi, where 42% of girls marry before age eighteen. An estimated 1.5 million girls in Malawi are at risk due to climate-exacerbated food insecurity and displacement. This paper, using feminist theories of intersectionality, postcolonial feminism, and feminist political ecology, examines the complex link between climate change and child marriage in Malawi. It critiques existing international, regional, and domestic policies, highlighting their inadequacy …

African Feminist Theories And The Gendered Dimensions Of Climate Change In Africa, Manase Kudzai Chiweshe

Journal of African Policy Studies

This paper analyzes how African feminist theories can provide nuanced insights into the gendered dimensions of climate change across the continent. African feminist theories provide essential insights into the everyday lived experiences of women within African spaces, allowing for a contextual analysis of the impacts of climate change. There has also been a growing recognition of the need to identify the gender-differentiated impacts of climate change. The main argument is not only that climate change will be experienced by men and women differently but also that the impacts will hurt women more severely. Yet this theorization must employ theoretical lenses …

The Healthcare Workforce In Nevada, 2024, Olivia K. Cheche, William E. Brown Jr., Caitlin J. Saladino

Health

This fact sheet presents data on the healthcare workforce in Nevada. The U.S. Bureau of Labor Statistics’ Occupational Employment and Wage Statistics Query System provides data on the amount of employment in all job sectors at the state and metropolitan statistical area (MSA) levels. This fact sheet focuses on employment and wage data for the State of Nevada, the Las Vegas-Henderson-Paradise, NV MSA, and the Reno, NV MSA as of May 2024.

District Impact On State-Wide Charter School Policy: Has Normandy Schools Collaborative Punctuated The Equilibrium? Charter School Policy Analysis Of The Missouri Department Of Elementary And Secondary Education, Tracey L. Cannon

Dissertations

Abstract

Punctuated Equilibrium Theory, as applied by Niles Eldredge and Stephen Jay Gould (1941-2002) to the study of species evolution, examined the infrequency of morphological change or stasis discontinuity.1 While groundbreaking in the field of Paleontology and the study of fossil change, the theory has been well-fitting to the decision sciences as introduced by Baumgartner and Jones2, in their 1993 and 2010 publications. Recognizing typical, incremental policy change, its use in this research looks at how stasis, stagnant policy can be punctuated by changes in political or societal views. This study examines the impact of heightened problem discussion for agenda …