Digital Commons Network^™

2022-11-29 Executive Council Minutes, Susie Salazar

Executive Council Minutes

No abstract provided.

2023-01-17 Leadership Council Minutes, Susie Salazar

Executive Council Minutes

No abstract provided.

2023-05-16 Executive Council Minutes, Susie Salazar

Executive Council Minutes

No abstract provided.

2021-06-01 Leadership Council Minutes, Susie Salazar

Executive Council Minutes

No abstract provided.

2021-09-21 Executive Council Minutes, Laura Bagley

Executive Council Minutes

No abstract provided.

2021-10-19 Executive Council Minutes, St. Mary's University

Executive Council Minutes

No abstract provided.

Targeted Delivery Of Rapamycin Via Epidermal Growth Factor Receptors In Pancreatic Cancer Cells Inhibits Cell Proliferation And Induces Apoptosis, Adeolu S. Oluremi, Christofer Baldwin, Nickolas L. Gustavision, Mujeebat Bashiru, Adeniyi Nsiah Oyebade, Noureen Siraj, Raj Raghavendra Rao, N. Ali

Biomedical Engineering Faculty Publications and Presentations

Pancreatic cancer (PC) is aggressive and deadly; most PC cells overexpress an epidermal growth factor receptor (EGFR). EGFR-targeting peptide (GE11) was conjugated to gold nanoparticles (AuNPs) for delivering rapamycin (Rap), an mTOR inhibitor that reduces proliferation and induces apoptosis. Biophysical techniques confirmed the conjugation. Rap loading efficiency was 41.5%, with sustained release at a lower pH. Conjugates showed higher uptake in PANC-1 cells than unmodified AuNPs. It also inhibited proliferation and induced apoptosis via pathways involving reactive oxygen species, mitochondrial damage, and caspase activation. This approach represents a promising nanoparticle-based therapeutic strategy targeting PC cells, utilizing GE11-EGFR interactions to minimize …

A Phase I Trial Of Evorpacept, Lenalidomide And Rituximab For Patients With B-Cell Non-Hodgkin Lymphoma, Paolo Strati, Lei Feng, Andrey Tyshevich, Darya Shavronskaya, Julia Alesse, Noel English, Elizabeth Sheehan, Nikita Syzrantsev, Alexander Nesmelov, Tony Z Zhuang, Dai Chihara, Jason R Westin, Sairah Ahmed, Luis E Fayad, Jared Henderson, Kylie Dent, Elizabeth Mcchesney, Sattva S Neelapu, Christopher R Flowers

Faculty, Staff and Student Publications

Introduction: SIRPα+ macrophages can mediate resistance to lenalidomide and rituximab (R2) in patients with B-cell non-Hodgkin lymphoma (B-NHL). Evorpacept (ALX148) is a novel CD47 blocker that abrogates interactions between lymphoma cells and SIRPα+ macrophages.

Methods: Adult patients with B-NHL who had received at least 2 prior lines of systemic therapy were included in this single arm phase I study (NCT05025800). Evorpacept was administered intravenously (IV), in a 28-day cycle, until progression, at two dose levels (DL): 30 mg/Kg on day (D) 1 and D15 (DL1), or 60 mg/Kg on day 1 (DL2); rituximab 375 mg/m2 IV was given …

Transforming Cancer Care: A Narrative Review On Leveraging Artificial Intelligence To Advance Immunotherapy In Underserved Communities, Victor M. Vasquez Jr., Molly Mccabe, Jack C. Mckee, Sharon Siby, Usman Hussain, Farah Faizuddin, Aadil Sheikh, Subramanian Dhandayuthapani, Shrikanth Gadad, Jessica Chacon

School of Medicine Publications

Purpose: Cancer immunotherapy has transformed oncology, but underserved populations face persistent disparities in access and outcomes. This review explores how artificial intelligence (AI) can help mitigate these barriers. Methods: We conducted a narrative review based on peer-reviewed literature selected for relevance to artificial intelligence, cancer immunotherapy, and healthcare challenges, without restrictions on publication date. We searched three major electronic databases: PubMed, IEEE Xplore, and arXiv, covering both biomedical and computational literature. The search included publications from January 2015 through April 2024 to capture contemporary developments in AI and cancer immunotherapy. Results: AI tools such as machine learning, …

Seeing Bias Through Eye Movements: Investigating Empathy And Engagement With Authentic And Altered Refugee Imagery, Reem Albaghli, Akshay Sunil Gurnaney, Nada Attar

Faculty Research, Scholarly, and Creative Activity

This study investigates perceptual biases in responses to Syrian and Ukrainian refugee images using human-computer interaction (HCI) techniques. We hypothesized that media portrayals might shape empathy and influence both biases and donation behavior. Participants viewed both authentic and face-swapped images, with eye-tracking data capturing pupil size and decision-making patterns. In Experiment 1, participants' eye-tracking data and donation behavior indicated higher engagement and donations for authentic images, suggesting a preference for unaltered images without ethnicity-based bias. Experiment 2 explored this further by presenting cropped refugee faces alongside neutral or intellectual art, asking participants to choose the art that best matched each …

Lessons In Longevity From Blood Stem Cells Under Protein Stress, André Catic

Center on Aging Staff Publications

Blood stem cells are among the body's longest-living cells despite being highly vulnerable to proteotoxic damage, which accelerates their aging. To maintain protein homeostasis (proteostasis), hematopoietic stem cells (HSCs) employ mechanisms such as reduced translation rates, high chaperone activity, autophagy, and selective protein degradation. These strategies mitigate protein misfolding, maintain quiescence, and preserve regenerative potential. Disruptions in proteostasis can lead to the elimination of impaired HSCs through differentiation or apoptosis, ensuring the integrity of the stem cell pool. Due to the systemic impact of the blood on aging and its experimental and clinical accessibility, investigating HSC proteostasis provides insights into …

Sleep Drive, Not Total Sleep Amount, Increases Seizure Risk, Vishnu Anand Cuddapah, Cynthia T Hsu, Fernanda Valle Sirias, Yongjun Li, Hrishit M Shah, Christopher Saul, Samantha Killiany, Camilo Guevara, Joy Shon, Zhifeng Yue, Gabrielle L Gionet, Mary E Putt, Amita Sehgal

Duncan NRI Faculty and Staff Publications

Sleep loss has been associated with increased seizure risk since antiquity. Using automated video detection of spontaneous seizures in Drosophila epilepsy models, we show that seizures worsen only when sleep restriction raises homeostatic "sleep drive," not simply when total sleep amount falls. This is supported by the paradoxical finding that acute activation of sleep-promoting circuits worsens seizures, because it increases sleep drive without changing sleep amount. Sleep-promoting circuits become hyperactive after sleep loss and are associated with increased whole-brain activity. During sleep restriction, optogenetic inhibition of sleep-promoting circuits to reduce sleep drive protects against seizures. Downregulation of the 5HT1A serotonin …

Structural Variants: Mechanisms, Mapping, And Interpretation In Human Genetics, Shruti Pande, Moez Dawood, Christopher M Grochowski

Faculty, Staff and Students Publications

Structural variations (SVs) represent genomic variations that involve breakage and rejoining of DNA segments. SVs can alter normal gene dosage, lead to rearrangements of genes and regulatory elements within a topologically associated domain, and potentially contribute to physical traits, genomic disorders, or complex traits. Recent advances in sequencing technologies and bioinformatics have greatly improved SV detection and interpretation at unprecedented resolution and scale. Despite these advances, the functional impact of SVs, the underlying SV mechanism(s) contributing to complex traits, and the technical challenges associated with SV detection and annotation remain active areas of research. This review aims to provide an …

Xpert Mtb/Rif Ultra Assay For Pulmonary Tuberculosis And Rifampicin Resistance In Adults And Adolescents, David J Horne, Jerry S Zifodya, Adrienne E Shapiro, Elizabeth Chandler Church, Jonah S Kreniske, Alexander W Kay, Katie Scandrett, Karen R Steingart, Yemisi Takwoingi

Faculty, Staff and Students Publications

Background: Xpert MTB/RIF Ultra (Xpert Ultra) is a molecular World Health Organization (WHO)-recommended rapid diagnostic test that simultaneously detects tuberculosis and rifampicin resistance. This review updates a comparative accuracy Cochrane review of Xpert MTB/RIF and Xpert Ultra as Xpert Ultra has replaced Xpert MTB/RIF.

Objectives: To determine the diagnostic accuracy of Xpert MTB/RIF Ultra (Xpert Ultra) for detecting pulmonary tuberculosis and rifampicin resistance in adults and adolescents with presumptive tuberculosis based on signs or symptoms or with an abnormal chest x-ray suggestive of tuberculosis.

Search methods: We searched seven databases including CENTRAL, MEDLINE, and Embase, plus two trial registers (ClinicalTrials.gov …

Cell Type-Specific Purifying Selection Of Synonymous Mitochondrial Dna Variation, Caleb A Lareau, Patrick Maschmeyer, Yajie Yin, Jacob C Gutierrez, Ryan S Dhindsa, Anne-Sophie Gribling-Burrer, Sebastian Zielinski, Yu-Hsin Hsieh, Lena Nitsch, Veronika Dimitrova, Benan Nalbant, Frank A Buquicchio, Tsion Abay, Robert R Stickels, Jacob C Ulirsch, Patrick Yan, Fangyi Wang, Zhuang Miao, Katalin Sandor, Bence Daniel, Vincent Liu, Paul L Mendez, Petra Knaus, Manpreet Meyer, William J Greenleaf, Anshul Kundaje, Redmond P Smyth, Mathias Munschauer, Leif S Ludwig, Ansuman T Satpathy

Duncan NRI Faculty and Staff Publications

While somatic variants are well-characterized drivers of tumor evolution, their influence on cellular fitness in nonmalignant contexts remains understudied. We identified a mosaic synonymous variant (m.7076A > G) in the mitochondrial DNA (mtDNA)-encoded cytochrome c-oxidase subunit 1 (MT-CO1, p.Gly391=), present at homoplasmy in 47% of immune cells from a healthy donor. Single-cell multiomics revealed strong, lineage-specific selection against the m.7076G allele in CD8+ effector memory T cells, but not other T cell subsets, mirroring patterns of purifying selection of pathogenic mtDNA alleles. The limited anticodon diversity of mitochondrial tRNAs forces m.7076G translation to rely on wobble pairing, unlike the Watson-Crick-Franklin pairing …

Burke’S Politics: Selected Writings And Speeches On Reform, Revolution, And War, Edmund Burke

Hannah Arendt Marginalia - All

New York, A.A. Knopf, 1949.

Call #: DA506 .B85 1949

Contains marginal lining and endpaper notes

PDF information – 73 pages – 6MB

Will In Western Thought; An Historico-Critical Survey, Vernon J. Bourke

Hannah Arendt Marginalia - All

New York, Sheed and Ward [1964]

Call #: BD450 .B64

Contains marginalia, underlining, and marginal lining

PDF Information: 39 pages – 35 MB

Prevalence Of Stress Urinary Incontinence In Female Strength Athletes, Meghan Rohde, Jason Brumitt, Jodi Sandvik, Kari Bo

Internet Journal of Allied Health Sciences and Practice

Background: Stress urinary incontinence (SUI) is a symptom during pregnancy and in the postpartum period, but a high prevalence of SUI is experienced in sports involving running and jumping. Objectives: Identify the scope of the problem of SUI in women participating in strength sports, movement patterns that elicit SUI, and the impact on quality of life in female athletes with SUI. Study Design: Survey mixed methods with qualitative focus groups. Methods: The International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF) and a sport-specific and obstetric/gynecological history questionnaire were sent to women who are United States citizens, age 18-65, and …

Navigating Cultural Barriers In Clinical Education: Unique Experiences And Insights From Culturally And Linguistically Diverse (Cald) Physiotherapy Students, Non-Cald Students, And Clinical Educators, Annie Yu, Neil Tuttle, Andrea Hams, Benjamin K. Weeks, Saras Henderson, Liisa Laakso

Internet Journal of Allied Health Sciences and Practice

Purpose: Culturally and Linguistically Diverse (CALD) students commonly face cultural barriers in the clinical learning environment that can impact on the success of clinical education experiences. Lack of effective strategies to facilitate clinical learning can be challenging for students and clinical educators alike. This study aimed to explore the issues impacting on clinical learning from the perspectives of CALD physiotherapy students and their clinical educators, and seeks suggestions from both participant groups to improve the clinical education experience. Methods: Qualitative descriptive design using grounded theory principles was utilised to gain insights from physiotherapy students and clinical educators regarding their clinical …

Increasing Clinical Placements For Occupational Therapy In A Social Services Setting: Innovations For Practice, Martin Fitzgerald, Becky Antich, Ele Grimwood

Internet Journal of Allied Health Sciences and Practice

Purpose: The provision of undergraduate clinical placements to support Allied Health education has always been a challenge. However, in the last few years, the mismatch between undergraduate students and available placements has become acute. This paper describes how an undergraduate occupational therapy programme and a Metropolitan Council provider of social services worked together to overcome these challenges. The aim was to enhance inter-institutional cooperation and placement educator support and to increase placement opportunities. Method: A series of meetings between the university and the host institution identified barriers and opportunities to placement expansion. For the host institution, these included the absence …

Evaluating Assistive Technologies In High Acuity Patients: A Scoping Review With Swot Analysis, Mallory Kargela Pt, Dpt, Amanda Anderson Pt, Dpt, Lindsay Anderson Pt, Dpt, Tian Gong Pt, Dpt, Kylie Scott Pt, Dpt, Edd

Internet Journal of Allied Health Sciences and Practice

Purpose: This publication examines the application of assistive technologies (AT) in high-acuity environments, including intensive care units (ICUs), acute care hospitals, and others. The aim is to systematically explore and synthesize the use of AT across these settings, identifying key strengths, weaknesses, opportunities, and threats (SWOT) associated. Methods: A literature search was conducted from 2016 to 2023 using PubMed, Tufts and Midwestern University Library databases. Search terms included ('physical therapy' OR 'physiotherapy') AND ('critically ill' OR 'acute' OR 'intensive care') AND ('assistive technology' OR 'technology' OR 'telerehabilitation' OR 'telePT' OR 'functional electrical stimulation' OR 'FES' OR 'cycle ergometry' …

Understanding The Relationship Between Occupation And Cognitive Abilities: A Preliminary Study, Deepak Puttanna, Srinidhi Konda, Mohammed Al Harbi

Internet Journal of Allied Health Sciences and Practice

Purpose: Understanding the cognitive abilities across various occupational backgrounds is deemed crucial, owing to the fact that the cognitive load imposed in each of the roles varies, thus there may be different levels of cognitive skills used in daily day-to-day activities. Also, it paves the way for the researchers to understand how an intellectually stimulating environment aids in better cognitive reserve or hinders cognitive decline. Method: A total of 60 participants aged between 30 to 50 years participated in the study. These participants were further divided into two broad groups, professional/technical workers and structural work occupations. These occupations were …

Constitutionalizing Traveling Feminisms In Kenya, Nkatha Kabira

Cornell International Law Journal

This Article uses selected provisions of the Constitution of Kenya 2010 to argue that although elaborate legal and institutional frameworks for promoting women’s empowerment have been adopted in Kenya’s legal framework, implementation of these provisions remains a challenge. Why is the law in the books so different from the law in action? This is the question this Article seeks to address. By mapping out how feminist ideas travel through collective action, colonial encounters, local, regional and world conferences, legislation, and other means, the Article demonstrates that the reason why implementation remains a challenge is that these ideas are often in …

An Introduction To Metaphysics, Henri Bergson

Hannah Arendt Marginalia - All

New York : Bobbs-Merrill [c1955]

Call #: BD112 .B42 1955

Contains underlining

PDF Information: 15 pages – 877 KB

Praxis And Action; Contemporary Philosophies Of Human Activity, Richard J. Bernstein

Hannah Arendt Marginalia - All

Philadelphia: University of Pennsylvania Press, 1971

Call #: BD450 .B44

Marginalia, marginal lining and underlining.

PDF Information: 15 pages – 7mb

The Beginning And The End, Nikolai Berdiaev

Hannah Arendt Marginalia - All

New York : Harper, 1957.

Call #: BD118.R8 B42 1957

Contains underlining and marginal lining

PDF information: 107 pages – 10.3MB

Teachers’ Talk About Children’S Texts, Sarah J. Mccarthey, Ngan Vu, Jiadi Zhang

Teaching/Writing: The Journal of Writing Teacher Education

Using a framework for discourses about writing, the qualitative study investigates teachers’ discussions about student texts during focus group sessions. The setting was a small, private school with a diverse student population and teachers who shared an approach to teaching. Their discussions focused on aspects of student writing including word choice and voice; learning to write within genres such as narrative, opinion, and poetry; and writing for an audience. Teachers valued multimodality by emphasizing how pictures and text can support one another throughout the writing process. The data reflect teachers’ knowledge of the students as writers and their cultural and …

“I Have Never Enjoyed Writing…” Exploring Pre-Service Teachers’ Divergent Perspectives And Responding To Student Writing, Nicole M. Martin, Lisa K. Hawkins, Jennifer Cooper Mrs.

Teaching/Writing: The Journal of Writing Teacher Education

Understanding of pre-service teachers’ [PSTs’] growth in practice is foundational to making the most of available opportunities in writing teacher preparation programs. We sought to examine differences in PSTs’ changes in reading and responding to student writing when their perspectives diverge from each other. Three PSTs enrolled in one learning-to-teach-writing course participated. Our comparisons of PSTs’ initial and end-of-semester reading and responding revealed varied changes within their core practice. PSTs’ variations displayed alignment to their divergent writing attitudes and beliefs. The results highlight the need for more nuanced attention to PSTs' growth in practice in future writing teacher preparation coursework.

Combining Bibliotherapy And Dialogue Journaling In A Fourth-Grade Book Club: Impact On Students’ Writing Apprehension, Leah A. Bryars, Bethanie C. Pletcher

Teaching/Writing: The Journal of Writing Teacher Education

This article presents the qualitative findings derived from a larger convergent-parallel mixed methods study that explored the outcomes of a bibliotherapy and dialogue journaling intervention on the writing apprehension of eight fourth-grade student participants in an after-school book club. In addition to transcripts of dialogue journal entries, other qualitative data included survey responses from the fourth-grade language arts teachers, field notes, and a post-intervention focus group interview. The qualitative data set was transcribed, coded, and analyzed for emergent themes. Qualitative findings suggested that the student participants demonstrated increased confidence and were in the process of developing more positive attitudes toward …

Ela Pre-Service Teachers Composing For Change: Public Letter Writing As Activist Endeavor, Mike P. Cook, Gail Harper Yeilding, Lindsey Ives

Teaching/Writing: The Journal of Writing Teacher Education

This study of five English Language Arts pre-service teachers draws on critical literacy and collective case study methods to examine how they talk about their own experiences with public letter writing as part of their writing methods course and they ways they perceive public letter writing as an activist endeavor. Our findings noted three interwoven themes—agency, advocacy, and focus on students—where participants talked about public letter writing as a way to develop and utilize agency, which allows them to advocate for students, teacher, themselves, education, etc. and to focus on students, especially as it relates to writing and writing instruction. …