Digital Commons Network^™

Finite Element Investigation Of Blast Load Responses In Nuclear Power Plant Containment Structures, Janak Raj Awasthi

Civil Engineering ETDs

Some significant incidents like the Chernobyl disaster (1986), the Fukushima Daiichi hydrogen explosion (2011), and some frequent military and terror threats to the nuclear Power plant structures have led to studying the capacity of power plant structures to withstand blast loadings. From this research, even one-third of the loss of the coolant is enough to damage the power plant structure. Crack starts from the wall and propagates toward the top of the dome and the foundation. The external blast shows high damage symptoms near the foundation area. Most of the steel members, including the rebars, Liner, and Tendons, showed high …

Elevated Nr2f1 Underlies The Persistence Of Invasive Disease After Treatment Of Braf-Mutant Melanoma, Manoela Tiago, Timothy J. Purwin, Casey D. Stefanski, Renaira Oliveira Da Silva, Mitchell E. Fane, Yash Chhabra, Jelan I. Haj, Jessica L. F. Teh, Rama Kadamb, Weijia Cai, Sheera Rosenbaum, Vivian Chua, Nir Hacohen, Michael A. Davies, Jessie Villanueva, Inna Chervoneva, Ashani T. Weeraratna, Dan A. Erkes, Claudia Capparelli, Julio A. Aguirre-Ghiso, Andrew E. Aplin

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Despite the success of targeted inhibitors in cutaneous melanoma, therapeutic responses are limited by the aged tumor microenvironment and drug-tolerant residual cells. Given the similarities between drug tolerance and cellular dormancy, we studied the dormancy marker, nuclear receptor subfamily 2 group F member 1 (NR2F1), in response to BRAF-V600E inhibitors (BRAFi) plus MEK inhibitors (MEKi) in BRAF-mutant melanoma models. Transcriptomic analysis of melanoma patient samples treated with BRAFi + MEKi showed increased NR2F1. NR2F1 was highly expressed in the drug-tolerant invasive cell state of minimal residual disease in patient-derived and mouse-derived xenografts on BRAFi + MEKi. NR2F1 over-expression was sufficient …

College Football Or Abortion Education? An Examination Of The University Of Arizona’S 1974 Stadium Bonds Bill, Emma Masterson

History ETDs

In 1974 the University of Arizona renovated their football stadium through a bonds bill passed by the state legislature. The renovations allowed the university to increase the stadium’s capacity by 17,000 seats. While in the state house, an Arizona Congressman attached a rider to the bonds bill banning the university’s medical school from performing abortions in most circumstances, effectively barring the university from teaching the medical students how to perform the procedure as well. This thesis seeks to position the University of Arizona football stadium renovations and abortion ban within the larger histories of American higher education and Arizona. This …

Optimizing Distributed Boundary Exchanges For Benchmarks, Solvers And Sparse Matrix Operations, Gerald Collom

Computer Science ETDs

Boundary exchanges dominate the cost of both stenciled codes and those that rely on sparse matrix operations. The performance of large boundary exchanges is limited by synchronization overheads and injection bandwidth limitations. Irregular boundary exchanges incur additional overheads due to the large number of required messages. This thesis investigates multiple methods for improving the performance and scalability of both Cartesian and irregular boundary exchanges. Since boundary exchanges are typically performed iteratively, persistent communication presents an opportunity for optimization by sharing and amortizing setup costs. Partitioned communication is also explored to increase asynchrony, reducing bottlenecks from synchronization overheads and data congestion. …

Exploring Immune System Through Computational Modeling: A Comprehensive Study Of Lymph Nodes And Immune Response Scaling, Vaccine Efficacy, And Large-Scale Extreme First Passage Time, Jannatul Ferdous

Computer Science ETDs

The adaptive immune response is a complex defense mechanism that develops over time to recognize and eliminate pathogens with remarkable precision and durability. This dissertation investigates the dynamics, scaling, and efficiency of the adaptive immune response through a synthesis of computational modeling, mathematical analysis, and agent-based simulations. First, we analyze the topology of the lymphatic network and investigate the T cell search time to find the lymph node that is containing the matching dendritic cell. Second we show how the scaling of lymph node number and volume with body mass, leads to scale-invariant search times for T cells locating antigen-bearing …

Experiences Of Women In K–12 Educational Technology Leadership Positions, Natalie M. Johnson

Walden Dissertations and Doctoral Studies

The problem addressed in this study was the lack of women in K–12 educational technology leadership positions in the United States. The purpose of this basic qualitative study was to explore the experiences of women in K–12 educational technology leadership regarding the challenges and successes they encountered in achieving and maintaining their positions. Feminist standpoint theory formed the framework for this study. Semistructured interviews were conducted with 10 women who were active or former K–12 educational technology leaders in public schools across the country. Open and pattern coding were used to support thematic analysis. An overarching theme of gender bias …

Secured Through Stone: The Power, Monuments, And Memory Of Thyra Danmarkarbót And The Jelling Dynasty, Jacquelyn Truitt

History ETDs

Sometime in the mid-tenth century on the Jutland peninsula of Denmark, the Viking Age Queen Thyra (d. ca. 958/9) passed away and the epithet Danmarkarbót—Denmark’s Adornment—was skillfully carved onto her memorial runestone. Yet Thyra’s story has been clouded by few and unreliable textual sources, by differing assessments of her familial background that have emerged from those sources, and by misrepresentations of the material culture relating to her. This thesis explores Thyra and her place within the Viking Age Jelling dynasty through textual and material evidence and considers how the construction of both medieval and modern memory work and memorialization …

From Backstage To Front Stage : Understanding Dramaturgical Work Behavior In The Workplace, Yufei Cheng

Lingnan Theses (MPhil & PhD)

Modern organizations often reward “looking busy” rather than genuinely contributing, prompting employees to engage in superficial displays of productivity. This type of behavior can be considered as a previously unexplored yet important form of impression management. While impression management research has predominantly examined outcome-oriented tactics, it has not fully captured the subtler, non-contributory forms of performative behavior that permeate everyday work life. To address this gap, this dissertation introduces Dramaturgical Work Behavior (DWB), a concept grounded in Goffman’ s dramaturgical theory, which outlines how employees enact symbolic “front-stage” performances—such as feigned urgency or exaggerated busyness—to signal conformity without adding real …

Glucose Metabolism And Its Direct Action In Cancer And Immune Regulation: Opportunities And Challenges For Metabolic Targeting, Bo-Syong Pan, Che-Chia Hsu, Hsin-En Wu, Yuan-Ru Chen, Xiaobo Zhou, Shu-Chi Wang, Chia-Yang Li, Hui-Kuan Lin

Faculty, Staff and Student Publications

Glucose metabolism is a pivotal hub for cellular energy production and the generation of building blocks that support cell growth, survival, and differentiation. Cancer cells undergo metabolic reprogramming to sustain rapid proliferation, survive in harsh microenvironments, and resist therapies. Beyond producing energy and building blocks to meet cancer cell demands, glucose metabolism generates numerous metabolites that serve as signaling molecules, orchestrating signaling pathways and epigenetic modifications that regulate cancer cell phenotypes and immunity. In this review, we discuss how glucose, through its metabolism and direct actions, influences diverse biological processes driving cancer progression and therapeutic resistance, while also exploring metabolic …

A Data Assimilation Framework For Predicting The Spatiotemporal Response Of High-Grade Gliomas To Chemoradiation, Hugo J M Miniere, David A Hormuth, Ernesto A B F Lima, Maguy Farhat, Bikash Panthi, Holly Langshaw, Mihir D Shanker, Wasif Talpur, Sara Thrower, Jodi Goldman, Sophia Ty, Caroline Chung, Thomas E Yankeelov

Faculty, Staff and Student Publications

Background: High-grade gliomas are highly invasive and respond variably to chemoradiation. Accurate, patient-specific predictions of tumor response could enhance treatment planning. We present a novel computational platform that assimilates MRI data to continually predict spatiotemporal tumor changes during chemoradiotherapy.

Methods: Tumor growth and response to chemoradiation was described using a two-species reaction-diffusion model of enhancing and non-enhancing regions of the tumor. Two evaluation scenarios were used to test the predictive accuracy of this model. In scenario 1, the model was calibrated on a patient-specific basis (n = 21) to weekly MRI data during the course of chemoradiotherapy. A data assimilation …

Neighborhood Environment And Incident Diabetes, A Neighborhood Environment-Wide Association Study ('Ne-Was'): Results From The Hispanic Community Health Study/Study Of Latinos (Hchs/Sol)., Cara M. Smith, Elizabeth W. Spalt, Linda C. Gallo, Jordan A. Carlson, Matthew Allison, Daniela Sotres-Alvarez, Christina Cordero, Qibin Qi, Earle C. Chambers, Martha Daviglus, Amber Pirzada, Gregory A. Talavera, Robert Kaplan, Joel D. Kaufman, Stephen J. Mooney

Manuscripts, Articles, Book Chapters and Other Papers

The prevalence of type 2 diabetes is increasing among the Hispanic/Latino population. Type 2 diabetes incidence rates vary between neighborhoods, but no single aspect of the neighborhood environment is known to cause type 2 diabetes. Using data from the Hispanic Community Health Study/Study of Latinos cohort of 16,415 Hispanic/Latino adults in four major US cities, we conducted a neighborhood environment-wide association study to identify neighborhood measures or clusters of measures associated with diabetes incidence. Two-hundred and four neighborhood measures were calculated at the census tract level or within a 1-km buffer of participants' residential addresses. Independent covariate-adjusted and survey-weighted Poisson …

Treatment With Allogenic Mesenchymal Stromal Cells For Moderate To Severe Acute Respiratory Distress Syndrome: A Double-Blind, Placebo-Controlled, Multi-Center, Phase 2b Clinical Trial (Stat), Michael A Matthay, Hanjing Zhou, Aartik Sarma, Narges Alipanah-Lechner, Carolyn Hendrickson, Lucy Z Kornblith, Martin Schreiber, David Zonies, Akram Khan, Bryce Robinson, Nicholas J Johnson, Lorraine B Ware, Oscar Guillamondegui, Jonathan Casey, Laura Moore, Bela Patel, Lillian Kao, Charles E Wade, Erin Fox, Charles Cox, Farrakh Khawanja, Robier Aguillon Prada, Sami Hossri, Rachael Callcut, Timothy Albertson, Kevin L Delucchi, Melanie Mcmillan, Charles R Langelier, Shibani Pati, David H Mckenna, Carolyn Leroux, Carolyn S Calfee, Kathleen D Liu

Faculty, Staff and Student Publications

Background: Prior clinical trials established the safety, but not the efficacy of bone marrow-derived mesenchymal stromal cells (MSCs) in the acute respiratory distress syndrome (ARDS).

Methods: We conducted a prospective, double-blind, multi-center randomized phase 2b clinical trial of one dose of intravenous MSCs (10 x 106/kg predicted body weight) versus placebo in 120 ventilated patients with ARDS (PaO2/FiO2 < 250 mmHg). The primary endpoint was change in oxygenation index (OI) over 36 hours from baseline.

Findings: Enrollment began in January 2020. Due to the Coronavirus 2019 (COVID-19) pandemic, the majority of subjects (101/120, 84%) developed ARDS from COVID-19. There were no significant baseline differences in severity of illness between patients treated with MSCs and those who received …

2022-09-13 Executive Council Meeting, Susie Salazar

Executive Council Minutes

No abstract provided.

2022-12-13 Executive Council Minutes, Susie Salazar

Executive Council Minutes

No abstract provided.

2023-03-07 Executive Council Minutes, Susie Salazar

Executive Council Minutes

No abstract provided.

2023-02-07 Leadership Council Minutes, Susie Salazar

Executive Council Minutes

No abstract provided.

2023-01-24 Executive Council Minutes, Susie Salazar

Executive Council Minutes

No abstract provided.

2023-04-25 Executive Council Minutes, Susie Salazar

Executive Council Minutes

No abstract provided.

2021-06-08 Executive Council Minutes, Susie Salazar

Executive Council Minutes

No abstract provided.

2021-08-24 Executive Council Minutes, Susie Salazar

Executive Council Minutes

No abstract provided.

2021-08-31 Leadership Council Minutes, St. Mary's University

Executive Council Minutes

No abstract provided.

2021-06-22 Executive Council Minutes, Dianne Pipes

Executive Council Minutes

No abstract provided.

2022-02-15 Leadership Council Minutes, St. Mary's University

Executive Council Minutes

No abstract provided.

2021-11-09 Leadership Council Minutes, Susie Salazar

Executive Council Minutes

No abstract provided.

2022-01-18 Executive Council Minutes, St. Mary's University

Executive Council Minutes

No abstract provided.

2022-05-31 Executive Council Minutes, St. Mary's University

Executive Council Minutes

No abstract provided.

2022-04-12 Leadership Council Minutes, St. Mary's University

Executive Council Minutes

No abstract provided.

Cd45 And Cd148 Are Critically Involved In Neutrophil Recruitment And Function During Inflammatory Arthritis In Mice, Jan-Niklas Heming, Andreas Margraf, Karolina Najder, Giulia Germena, Mathis Richter, Anika Cappenberg, Katharina Henke, Bernadette Bardel, Lena Schemmelmann, Marina Oguama, Pia Lindental, Wida Amini, Jacqueline Sobocik, Georg Schett, Gerhard Krönke, Helena Block, Jan Rossaint, Oliver Soehnlein, Alexander Zarbock

Faculty, Staff and Student Publications

Neutrophils play a key role in autoimmune diseases like rheumatoid arthritis, contributing to tissue damage through rapid recruitment and activation. In this study, we investigated the regulatory properties of two receptor-like tyrosine phosphatases (RPTPs), CD45 and CD148, in inflammatory arthritis. Using an in vivo mouse model of K/BxN serum transfer-induced arthritis, we found that CD45 and CD148 feature distinct regulatory properties during inflammatory arthritis. CD45 is required for neutrophil infiltration, cytokine release, and reactive oxygen species production, whereas CD148 deficiency leads to a delayed onset of arthritis but unaltered overall neutrophil infiltration and reduced ROS production. Furthermore, we could demonstrate …

Network Intelligence For Next-Generation Wireless Networks: Advancing Distribution And Coordination, Yonatan Melese Worku

Electrical and Computer Engineering ETDs

Next-generation wireless networks, encompassing 6G and beyond, face rigorous demands for ultra-low latency, ubiquitous connectivity, exceptionally high data rates, and robust security, necessitating innovative approaches to resource optimization and network protection. This dissertation proposes a pioneering framework that synergizes advanced methodologies—deep reinforcement learning, deep learning, blockchain, and multi-agent systems—to address these challenges. Distributed architectures, underpinned by AI-driven multi-agent systems, form the backbone of this framework, enabling seamless integration and intelligent orchestration across diverse domains. The research advances IoT-based systems leveraging machine learning for resource efficiency in healthcare applications, develops reinforcement learning-driven frameworks to optimize energy and coverage for Unmanned Aerial …

Classifying Heterogeneous Cooperation In Social Dilemmas: Experimental Evidence And Simulation Insights, Sining Wang

Faculty Scholarship

In this paper, we introduce a revealed strategy method to capture heterogeneous behavioral patterns in repeated public goods experiments. This method identifies an individual’s strategic type—a stable decision-making tendency in interactive settings—by analyzing behavioral profiles. We conduct a repeated public goods game to collect participants’ behavioral data and then apply both k-medians and hierarchical clustering algorithms to classify them into five distinctive types: free riders, strong cooperators, above-average conditional cooperators, below-average conditional cooperators, and hump-shaped players. These classifications are then used to construct and calibrate an agent-based simulation model. Our simulation results suggest that policies targeting how conditional cooperators respond …