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Development Of Dynamic Proof-Mass Configurations For Broadband Piezoelectric Energy Harvesting, Nico E. Galarza Jul 2026

Development Of Dynamic Proof-Mass Configurations For Broadband Piezoelectric Energy Harvesting, Nico E. Galarza

Electrical and Computer Engineering ETDs

The purpose of this thesis is to investigate and develop dynamic proof-mass configurations for broadband piezoelectric energy harvesting. Conventional piezoelectric energy harvesters are typically limited by narrow operating bandwidths, restricting their performance under variable-frequency excitation. This research presents the design, fabrication, and experimental evaluation of multiple proof-mass concepts intended to increase the usable frequency range of cantilever-based piezoelectric energy harvesters. Several dynamic mass configurations were developed using additive manufacturing techniques and integrated with commercially available piezoelectric cantilevers. Experimental testing was conducted under controlled vibration conditions to characterize voltage response, resonant behavior, and bandwidth performance. The results demonstrate that dynamic proof-masses …


Synergizing Crowd Collaboration: Enhancing Crowdsourcing Matching Via Integration Of Matching Theory And Coalition Games, Rowan Aengus Kinney Jul 2026

Synergizing Crowd Collaboration: Enhancing Crowdsourcing Matching Via Integration Of Matching Theory And Coalition Games, Rowan Aengus Kinney

Electrical and Computer Engineering ETDs

This paper tackles the challenges inherent in crowdsourcing dynamics by introducing the CROWDMATCH mechanism. Aimed at enabling crowdworkers to strategically select suitable crowdsourcers while contributing information to crowdsourcing tasks, CROWDMATCH considers incentives, information availability and cost, and the decisions of fellow crowdworkers to model the utility functions for both the crowdworkers and the crowdsourcers. Specifically, the paper presents an initial Approximate CROWDMATCH mechanism grounded in matching theory principles, eliminating externalities from crowdworkers’ decisions and enabling each entity to maximize its utility. Subsequently, the Accurate CROWDMATCH mechanism is introduced, being initiated by the outcome of the Approximate CROWDMATCH mechanism, and employing …


Making Meaning Of Gendered Experiences: A Mixed Methods Analysis Among U.S. College Students, Andrea Bancroft Jul 2026

Making Meaning Of Gendered Experiences: A Mixed Methods Analysis Among U.S. College Students, Andrea Bancroft

Individual, Family, and Community Education ETDs

Gender inequities rooted in patriarchal norms shape the experiences of college-going emerging adults across many domains, often to the detriment of young women. In this study, we applied a mixed-methods approach to analyzing how college students interpret and make meaning from gendered experiences, and how the meaning making process relates to these emerging adults’ sense of university belonging. Participants provided written narratives of a gendered experience and completed a survey about university belonging. Through our qualitative analyses of the narrative responses, we identified four themes that represent cultural socialization messages that these participants engaged with in their narratives: bioessentialism, expectations …


Investigating Light-Matter Interactions In Low-Dimensional Silicon Carbide, Nishan Shrestha Jul 2026

Investigating Light-Matter Interactions In Low-Dimensional Silicon Carbide, Nishan Shrestha

Mechanical Engineering ETDs

Recent advances in materials science have transformed the study and application of low-dimensional materials, with two-dimensional (2D) systems and nanoscale structures exhibiting properties beyond their bulk counterparts. Despite significant progress in materials such as graphene and silicon, the nanoscale exploration of silicon carbide (SiC) remains relatively underdeveloped, despite its critical importance in photonics and electronics and high temperature applications. Motivated by the transformative potential of nanoscale material design and the technological importance of SiC, this dissertation investigates structure and properties of low-dimensional silicon carbide structures. It explores the synthesis and optical properties of SiC nanosheets and nanowires using a variety …


Simulations Of Atmospheric Pressure Streamer Discharges: Mechanisms Of Streamer Propagation And Related Physics, Dejan Nikic Jul 2026

Simulations Of Atmospheric Pressure Streamer Discharges: Mechanisms Of Streamer Propagation And Related Physics, Dejan Nikic

Electrical and Computer Engineering ETDs

Gas discharge simulations are performed with particular focus on photoionization process in a positive streamer discharge. The effects of this process are investigated by isolating the change in photoionization mean free path (MFP) and keeping the additional processes constant. Furthermore, comparison are made between various effects of simulation parameters, such as initial conditions, geometry extent, simula- tion particle count etc. All of these simulations are performed using a modern Direct Simulation Monte Carlo Particle-in-Cell (DSMC-PIC) code developed by Sandia Na- tional Laboratories. Large scale simulations including 1 cm and 5 cm electrode gaps are performed under standard atmospheric condition air. …


Computationally Tractable Methods For Constrained Optimal Control And Reachability Analysis Of Nonlinear Stochastic Dynamical Systems, Karthik Sivaramakrishnan Jul 2026

Computationally Tractable Methods For Constrained Optimal Control And Reachability Analysis Of Nonlinear Stochastic Dynamical Systems, Karthik Sivaramakrishnan

Electrical and Computer Engineering ETDs

Autonomous systems operating in uncertain environments require methods that can rigorously quantify safety, predict future behavior, and compute optimal decisions tractably. The unifying challenge is reasoning about uncertainty propagation in constrained dynamical systems. Motivated by autonomous spacecraft inspection, this dissertation develops model-based and data-driven methods for stochastic optimal control and stochastic reachability. First, it studies optimal on-orbit inspection of an uncertain tumbling spacecraft in both single-agent and multi-agent settings, and derives computationally efficient reformulations for exploring trade-offs among sensing, trajectory deviation, and fuel use. Second, it develops a probabilistically safe penalty-based reinforcement learning method that preserves gradient information during training …


Notch Signaling Regulates The Secretion Of Pro-Metastatic Factors In Extracellular Vesicles In Liposarcoma, Menchus Quan, Yi-Kai Liu, Ying Zhao, Madeline Kay, Kai Sun, Timothy P Gavin, Raphael E Pollock, W Andy Tao, Shihuan Kuang Jul 2026

Notch Signaling Regulates The Secretion Of Pro-Metastatic Factors In Extracellular Vesicles In Liposarcoma, Menchus Quan, Yi-Kai Liu, Ying Zhao, Madeline Kay, Kai Sun, Timothy P Gavin, Raphael E Pollock, W Andy Tao, Shihuan Kuang

The Brown Foundation: Institute of Molecular Medicine

Notch signaling is an emerging regulator of liposarcoma (LPS), but its role in mediating communication with the tumor microenvironment (TME) is unclear. Here, we investigate how Notch activation (NICD overexpression) alters the proteomes of LPS-derived extracellular vesicles (EVs). We used quantitative mass spectrometry to profile the EV proteome in multiple contexts: cultured LPS cells, LPS tumor, circulating EVs of LPS-bearing mice, and human LPS samples. We found that Notch signaling increases the secretion of EV proteins that favor tumor progression and metastasis but suppresses immune responses in murine LPS cells. Overlapping murine and human LPS data identifies 18 proteins that …


Exploring The Nature And Role Of Local Cation Ordering In Disordered Rock Salt Cathodes For Li- And Na-Ion Batteries, You Wang Jul 2026

Exploring The Nature And Role Of Local Cation Ordering In Disordered Rock Salt Cathodes For Li- And Na-Ion Batteries, You Wang

Chemistry and Chemical Biology ETDs

Cation-disordered rock-salt (DRX) cathodes provide a highly tunable platform for next-generation Li- and Na-ion batteries, but their electrochemical behavior is strongly influenced by local structural features hidden in average crystal structures. This dissertation systematically investigates local cation ordering in Li- and Na-based DRX cathodes to understand its effects on Li+/Na+ transport, redox activity, structural evolution, and electrochemical performance. In Li-based systems, Raman spectroscopy and electrochemical analysis reveal that local layered cation ordering in Mn- and Fe-based DRX cathodes is closely correlated with electrochemical behavior. Over-stoichiometric Li-based DRX oxyfluorides further demonstrate that excess Li can regulate local cation ordering, improve Li+ …


Ophthoevidence Report: Comparative Effects Of Prophylactic Strategies For Post-Intravitreal Injection Endophthalmitis: Protocol For A Systematic Review And Network Meta-Analysis, Maryam Ghadimi, Dena Zeraatkar, João Pedro Lima, Jinhui Ma, Sunir J. Garg, Peter Kaiser, David Steel, Tien Yin Wong, Sobha Sivaprasad, Charles Wykoff, Varun Chaudhary Jul 2026

Ophthoevidence Report: Comparative Effects Of Prophylactic Strategies For Post-Intravitreal Injection Endophthalmitis: Protocol For A Systematic Review And Network Meta-Analysis, Maryam Ghadimi, Dena Zeraatkar, João Pedro Lima, Jinhui Ma, Sunir J. Garg, Peter Kaiser, David Steel, Tien Yin Wong, Sobha Sivaprasad, Charles Wykoff, Varun Chaudhary

Wills Eye Hospital Papers

BACKGROUND: Endophthalmitis is a rare but serious complication of intravitreal injections (IVI). To mitigate the risk of post-injection endophthalmitis (PIE), retinal specialists use different strategies, combining various prophylactic measures. However, existing systematic reviews have evaluated the effects of these measures in isolation, which does not consider their concurrent use in practice. A trustworthy systematic review with network meta-analysis (NMA) by providing a framework for simultaneous comparisons of different prophylactic combinations is essential to guide decision-making.

OBJECTIVES: To present a protocol for addressing the comparative effects of different strategies for the prevention of PIE.

METHODS: We will search Medline, EMBASE, Cochrane …


Ai-Powered Resume Screening, Sang Suh, Numery Zaber Jul 2026

Ai-Powered Resume Screening, Sang Suh, Numery Zaber

Faculty Publications

Traditional resume screening is manual, slow, and susceptible to bias, and it struggles to keep pace with today’s application volumes. This paper presents a dual-engine, AI-powered resume screening system designed for transparency and reproducibility. The primary (classical) pipeline encodes resumes and job descriptions using Sentence-BERT (SBERT), computes a resume–job match score via cosine similarity, classifies candidates into 25 job categories using XGBoost, and provides model interpretability through SHAP. In parallel, a prompted large language model (LLM) baseline (GPT-4o/4o-mini) outputs a match score and predicted category for comparative analysis. A Streamlit-based interface integrates both engines to support recruiter workflows and human-in-the-loop …


Civilian Threat Reduces Distance Perceptions And Officer Punishment In Police Use-Of-Force Encounters, Stephanie A. Cárdenas, Kristyn A. Jones, Yael Granot, Emily Balcetis Jul 2026

Civilian Threat Reduces Distance Perceptions And Officer Punishment In Police Use-Of-Force Encounters, Stephanie A. Cárdenas, Kristyn A. Jones, Yael Granot, Emily Balcetis

Psychology: Faculty Publications

People turn to video evidence to make judgments about the justifiability of an officer’s actions in use-of-force incidents. Despite beliefs that video offers an objective account of events, use-of-force footage elicits different judgments among those watching it. Across four experiments (Ntotal = 2615), we investigated whether discrepant punishment judgments arise in part because of differences in perceptions of the physical space that separates an officer and civilian. We focus on third-party observers’ subjective perceptions, as they shape public discourse and justice outcomes, influence institutional accountability, and fuel public response. Despite watching the same video, civilians appeared physically closer to officers …


De Novo Pyrimidine Synthesis Controls Germinal Center B Cell And Plasma Cell Fates And Systemic Autoimmunity, Julia L. Weber, Tien Bui, Keomonyroth Nuon, Adam J. Fike, Sophia M. Crocker, Kristen N. Bricker, Anju Maharjan, Wujuan Zhang, Aaron R. Goldman, Sathi Babu Chodisetti, Ziaur S. M. Rahman Jul 2026

De Novo Pyrimidine Synthesis Controls Germinal Center B Cell And Plasma Cell Fates And Systemic Autoimmunity, Julia L. Weber, Tien Bui, Keomonyroth Nuon, Adam J. Fike, Sophia M. Crocker, Kristen N. Bricker, Anju Maharjan, Wujuan Zhang, Aaron R. Goldman, Sathi Babu Chodisetti, Ziaur S. M. Rahman

Department of Microbiology and Immunology Faculty Papers

Whether and how pyrimidine metabolites promote systemic autoimmunity is unknown. Here, metabolomics and 15N-amide glutamine tracing show enhanced flux through de novo pyrimidine synthesis in systemic lupus erythematosus (SLE)-prone B cells. Temporal inhibition of pyrimidine synthesis dampens SLE-prone but not foreign antigen-specific germinal center (GC), plasma cell (PC), and antibody responses. Uridine monophosphate synthase (UMPS) conditional deletion, however, reveals a B cell-intrinsic requirement of de novo pyrimidine synthesis in foreign antigen-driven and SLE-prone GC, PC, and antibody responses and kidney immune complex deposition. Metabolomics, mitochondrial stress test, metabolic flow cytometry, glycolytic rate assay, and RNA sequencing highlight the importance of …


Arts & Literature: Playing At Lemkin's House, Connie Winston Jul 2026

Arts & Literature: Playing At Lemkin's House, Connie Winston

Genocide Studies and Prevention: An International Journal

No abstract provided.


Table Of Contents Jul 2026

Table Of Contents

Genocide Studies and Prevention: An International Journal

No abstract provided.


Genocide By Algorithm In Gaza: Artificial Intelligence, Countervailing Responsibility, And The Corruption Of Public Discourse, Branislav Radeljić Jul 2026

Genocide By Algorithm In Gaza: Artificial Intelligence, Countervailing Responsibility, And The Corruption Of Public Discourse, Branislav Radeljić

Genocide Studies and Prevention: An International Journal

The accelerating militarization of artificial intelligence (AI) has transformed the ethics, politics, and governance of warfare. This article interrogates how AI-driven targeting systems function as epistemic infrastructures that classify, legitimize, and execute violence, using Israel’s conduct in Gaza as a paradigmatic case. Building on interdisciplinary debates in security studies, critical technology studies, and international law, the paper advances the concept of "genocide by algorithm"—a mode of technologically mediated extermination in which opaque computational systems automate and rationalize mass violence. The study argues that these systems collapse distinctions between military and civilian targets, and between intentional and accidental harm, thereby eroding …


Genocidal Occupation And The Occupier’S Dilemma: From Lemkin’S Axis Rule To 21st Century Palestine, Martin Shaw Jul 2026

Genocidal Occupation And The Occupier’S Dilemma: From Lemkin’S Axis Rule To 21st Century Palestine, Martin Shaw

Genocide Studies and Prevention: An International Journal

Following Israel’s campaign in Gaza after October 7, 2023, which was widely recognized as a genocide, the “ceasefire” of late 2025 introduced the prospect of a new occupation of the territory by the USA and Israel, leading to its redevelopment by them rather than the restoration of the pre-2023 Palestinian society. Together with the parallel accentuation of Palestinian dispossession under Israeli occupation in the West Bank, this development calls for a theorization of the relationship between occupation and genocide. Yet, although the concept of genocide was introduced by Raphael Lemkin in his analysis of the German occupations of European countries, …


U.S. Public Opinion During The Rwandan Genocide And The Power Of Executive Detachment, Carly Schmitt, Matthew L. Bergbower Jul 2026

U.S. Public Opinion During The Rwandan Genocide And The Power Of Executive Detachment, Carly Schmitt, Matthew L. Bergbower

Genocide Studies and Prevention: An International Journal

We examine U.S. public opinion during the Rwandan genocide in the spring and early summer of 1994. Drawing on more than a dozen public opinion polls fielded during this period, we analyze Americans’ levels of knowledge about the violence in Rwanda, their views on United Nations involvement, support for U.S. military intervention, and evaluations of President Bill Clinton’s handling of the crisis. Longstanding theory recognizes public opinion as an important variable in explaining foreign policy choices during international crises. In the case of U.S. policy toward the Rwandan genocide, our analysis reveals widespread public unfamiliarity with a distant African conflict …


Arts & Literature: Living On The Margins, Bashir Cassimally Jul 2026

Arts & Literature: Living On The Margins, Bashir Cassimally

Genocide Studies and Prevention: An International Journal

Living on the Margins follows the parallel journey of a mountain gorilla and a Batwa youth in Rwanda against the backdrop of displacement and genocide. The story explores the marginalization of a human community and the bond between people, animals, and land.


Book Review: Uyghur Women Activists In The Diaspora: Restorying A Genocide, Robert W. Wilson Jul 2026

Book Review: Uyghur Women Activists In The Diaspora: Restorying A Genocide, Robert W. Wilson

Genocide Studies and Prevention: An International Journal

No abstract provided.


Book Review: The Futures Of Reparations In Latin America: Imagination, Translation, And Belonging, Jakob Leichtman Jul 2026

Book Review: The Futures Of Reparations In Latin America: Imagination, Translation, And Belonging, Jakob Leichtman

Genocide Studies and Prevention: An International Journal

No abstract provided.


Cmsi Note 22: Testing Boundaries: The Lan Hai 201 Mission East Of Taiwan, Ryan D. Martinson Jul 2026

Cmsi Note 22: Testing Boundaries: The Lan Hai 201 Mission East Of Taiwan, Ryan D. Martinson

CMSI Notes

Key Takeaways

  • From 17-23 July, the People’s Republic of China (PRC) deployed a 3,000-ton fisheries research ship, the Lan Hai 201, to waters east of Taiwan. China’s Ministry of Agriculture and Rural Affairs, which owns the vessel, declared that the cruise was intended to “comprehensively understand the state of fisheries resources in China’s jurisdictional space.”
  • During its cruise, the Lan Hai 201 engaged in survey activities in the EEZs of Taiwan, Japan, and the Philippines, in clear violation of their sovereign rights to regulate fisheries resources under the United Nations Convention on the Law of the Sea.
  • On 22 July, …


Wildfire Impacts On Fluvial Hydrology From Watershed To National Scales, Paige G. Tunby Jul 2026

Wildfire Impacts On Fluvial Hydrology From Watershed To National Scales, Paige G. Tunby

Civil Engineering ETDs

Wildfires alter the water quantity and quality in downstream river networks. Fires promote biodiversity, maintain habitat, and provide many ecosystem services in a fire-adapted landscape. However, changes in the natural fire regimes can alter ecosystem function and threaten the water security of impacted downstream communities. The magnitude, timing, and persistence of these impacts are difficult to predict due to the lack of high-resolution datasets with adequate coverage to evaluate spatiotemporal trends after a fire. This dissertation moves us beyond the status quo to evaluate post-fire fluvial responses across scales, from the event-scale impacts after the Hermit’s Peak-Calf Canyon wildfire in …


Effect Of Geothermal Conditions On Silica Flour Modified Wellbore Cement, Travis Benjamin Broadhurst Jul 2026

Effect Of Geothermal Conditions On Silica Flour Modified Wellbore Cement, Travis Benjamin Broadhurst

Civil Engineering ETDs

Considerable work has been conducted on modified wellbore cements, but a knowledge gap exists in the effects of downhole conditions on cement, especially tensile strength. In this study, a pressure vessel simulates representative downhole conditions (2000C, 1.5 MPa) with a reference solution for geothermal brine and naturally occurring geothermal gases. Samples are removed after 28-days for unconfined compressive strength testing, Brazilian tensile strength testing, elastic moduli measurement, and chemical analyses by X-ray diffraction and electron microprobe. Aqueous chemical analysis suggests multiple active reactions between the geothermal fluid and cement that are exacerbated by higher temperatures, but do not …


Mechanisms Of Advanced And Energy Efficient Wastewater Treatment Technologies, Derek Belka Jul 2026

Mechanisms Of Advanced And Energy Efficient Wastewater Treatment Technologies, Derek Belka

Civil Engineering ETDs

This dissertation combines meta-omics, microbial ecology, and hydrodynamic analysis to explore mechanisms of enhanced biological phosphorus removal (EBPR) and aerobic granular sludge (AGS) in municipal wastewater treatment. Metagenomic and functional gene profiling of a laboratory sequencing batch reactor fed with amino acids and proteins, and with a low abundance of known polyphosphate-accumulating organisms (PAOs), revealed abundant Herpetosiphonaceae and Dermatophilaceae families possessed key PAO metabolic traits, including phosphate scavenging, anaerobic carbon pathways, and ppk2 gene variants aligned with established PAOs. These findings suggest amino acid-driven EBPR can occur via previously unrecognized taxa, challenging current engineering assumptions and highlighting the need for …


K-12 Teachers’ Perspectives On The Adoption Of Virtual Reality And Augmented Reality Technology In Classroom Instruction, Breanna Mckenley Jul 2026

K-12 Teachers’ Perspectives On The Adoption Of Virtual Reality And Augmented Reality Technology In Classroom Instruction, Breanna Mckenley

Walden Dissertations and Doctoral Studies

The problem addressed in this basic qualitative study was that although some K–12 teachers have access to virtual reality (VR) and augmented reality (AR) technologies, these tools are not widely accepted or adopted for classroom instruction. Guided by the technology acceptance model, the purpose of the study was to explore K–12 teachers’ perspectives on their willingness to incorporate VR/AR, the perceived usefulness and ease of use of these technologies, and the challenges they encounter or anticipate during the adoption process. Semistructured interviews were conducted with 10 K-12 teachers from public, charter, and private schools in the United States who had …


Investigating The Corrosion Behavior Of Stainless Steel 316 In Static Lead Lithium Eutectic Under Applied Stressed Conditions, Daniel E. Levario Jul 2026

Investigating The Corrosion Behavior Of Stainless Steel 316 In Static Lead Lithium Eutectic Under Applied Stressed Conditions, Daniel E. Levario

Nuclear Engineering ETDs

As fusion power moves closer to feasibility, identifying structural materials compatible with breeding blanket environments remains a critical challenge. Lead-lithium eutectic (LLE) is a leading candidate breeder and coolant material due to its low melting point and combined tritium breeding and neutron multiplication capability. However, the corrosive nature of LLE toward structural steels at elevated temperatures must be characterized before these systems can be reliably deployed. This study investigates the corrosion behavior of Type 316 stainless steel in static LLE under applied stress conditions at 550°C using C-ring stress corrosion specimens. Post exposure analysis via optical microscopy, SEM, EDS, and …


Under Pressure: Negative Urgency And Disordered Eating In The Context Of Parental Differential Support, Hamide Gozu, Jenna K. Rieder Jul 2026

Under Pressure: Negative Urgency And Disordered Eating In The Context Of Parental Differential Support, Hamide Gozu, Jenna K. Rieder

College of Humanities and Sciences Faculty Papers

Disordered eating behaviors are prevalent in emerging adulthood and may be shaped by family dynamics. This study examined associations among maternal and paternal differential support, weight-shape concerns, and binge eating and compensatory behaviors in emerging adulthood, while testing the moderating role of negative urgency. Participants were 517 emerging adults from across the United States (ages 18-29; M = 22.60, SD = 3.81; 76% female). Participants reported on parental differential support, weight-shape concerns, eating behaviors, and negative urgency. Using moderated-mediation analyses, we found that weight-shape concerns mediated associations between differential support and eating behaviors. Unequal maternal support and paternal favoritism showed …


Elucidation Of Spin-Hamiltonian Parameters Via Spectroscopy, Magnetization, And Computation, Joshua C. Mengell Jul 2026

Elucidation Of Spin-Hamiltonian Parameters Via Spectroscopy, Magnetization, And Computation, Joshua C. Mengell

Chemistry and Chemical Biology ETDs

Molecular Quantum Information Science (QIS) is fundamentally concerned with using spin-systems as quantum bits (qubits) or as sensors. Prerequisite to using molecular systems for QIS applications, it must be understood how one can design molecules with bespoke magnetic characteristics. Herein we study various paramagnetic molecular compounds, describing their complex magnetic characteristics using a spin-Hamiltonian formalism. We utilize various (sometimes novel) methods for determining these spin-Hamiltonian parameters. Many of these molecules possess magnetic characteristics, which make them attractive as qubits or for sensing applications. These characteristics include higher total spin-states (qudits—ST>1/2), forbidden interstate electronic transitions, systems of spatially distant …


Examining Conditional Indirect Media Effects Through Normative Perceptions: The Role Of Traditional Family Gender Role Expectations And Stigmatizing Beliefs In Human Papillomavirus Vaccination, Moonsun Choi Jul 2026

Examining Conditional Indirect Media Effects Through Normative Perceptions: The Role Of Traditional Family Gender Role Expectations And Stigmatizing Beliefs In Human Papillomavirus Vaccination, Moonsun Choi

Communication ETDs

This dissertation examines how indirect media effects operate through normative perceptions within a gendered and stigmatized health context of HPV vaccination. Specifically, this study investigates how these normative mediation processes are conditioned by traditional family gender role expectations at the norm formation stage and stigmatizing beliefs about HPV vaccination at the normative influence stage. A cross-sectional survey was conducted with mothers of children aged 9 – 12 in the United States in June 2025. The key findings show that while gendered perceptions of HPV vaccination persist, the underlying normative mechanism operated in similar ways across gender-referent contexts. Injunctive norms were …


Uv Damage Mapping Reveals Different Impacts Of Xpd Mutations On Global Genomic And Transcription-Coupled Dna Repair, Allyson Hoag Jul 2026

Uv Damage Mapping Reveals Different Impacts Of Xpd Mutations On Global Genomic And Transcription-Coupled Dna Repair, Allyson Hoag

Biomedical Sciences ETDs

Nucleotide Excision Repair (NER) is a fundamental cellular process that removes bulky and helical distorting lesions from the genome through the separate responses of its two subpathways – global genomic (GG-NER) and transcription coupled (TC-NER) DNA repair. The pathways converge with the recruitment of the TFIIH complex, a key step that is mediated by the translocase and helicase activities of  its XPD subunit. Germline mutations in XPD result in the clinical disorders, Xeroderma Pigmentosum (XP) and XP combined with Cockayne Syndrome (XP/CS). The goal of this thesis was to understand if XPD XP and XP/CS mutations differentially impact GG-NER and …