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What Was I Made For?, Maythazin Minthu Sep 2025

What Was I Made For?, Maythazin Minthu

Ovid

No abstract provided.


Faith Without Borders, Kylie Sarkovics Sep 2025

Faith Without Borders, Kylie Sarkovics

Ovid

No abstract provided.


Psychometric Validation Of The Modified Fatigue Impact Scale (Mfis) In Individuals With Heart Failure, Rita De Cassia Gengo E Silva Butcher Sep 2025

Psychometric Validation Of The Modified Fatigue Impact Scale (Mfis) In Individuals With Heart Failure, Rita De Cassia Gengo E Silva Butcher

Sigma Foundation for Nursing Research Grant Reports

Evaluation of fatigue remains challenging.

The aim of the study was to (1) access the reliability of the Modified Fatigue Impact Scale (MFIA) and (2) to evaluate the internal structure and convergent, divergent, and construct validity of the MFIS.

The study objective was partially achieved, as it was not possible to recruit the full number of participants originally estimated in the sample size calculation (N = 116).


The Use Of Indigenous Plants In Home And Health Clinic Gardens To Engender Urban Rewilding In The Urban And Peri-Urban Areas Of The North-West Province, South Africa, Nanamhla Gwedla, Sonja De Beer, Dikeledi Seshoka, Sarel S. Cilliers Sep 2025

The Use Of Indigenous Plants In Home And Health Clinic Gardens To Engender Urban Rewilding In The Urban And Peri-Urban Areas Of The North-West Province, South Africa, Nanamhla Gwedla, Sonja De Beer, Dikeledi Seshoka, Sarel S. Cilliers

Cities and the Environment (CATE)

There is a need to rethink the sustainability and resilience of cities, where there is often limited availability and access to urban green spaces (UGS). Urban rewilding is an opportune avenue to connect humans to nature. Thus, the aim of this study was to understand the potential for urban re-naturing through home and health clinic gardens (HCGs). This was done through vegetation surveys in the naga (natural area) micro-gardens of 16 HCGs and household surveys with 80 households with home gardens (HGs) in two districts of the North-West province, South Africa. The size of the naga across HCGs ranged from …


Performance Fatigability At Task Failure And Beyond: Distinct Patterns Of Recovery Following Constant Load Versus Intermittent Cycling Exercise, Zachary J. Mcclean, Keenan Macdougall, Matthew J. Jordan, Danilo Iannetta, Martin Macinnis, Saied J. Aboodarda Sep 2025

Performance Fatigability At Task Failure And Beyond: Distinct Patterns Of Recovery Following Constant Load Versus Intermittent Cycling Exercise, Zachary J. Mcclean, Keenan Macdougall, Matthew J. Jordan, Danilo Iannetta, Martin Macinnis, Saied J. Aboodarda

International Journal of Exercise Science

International Journal of Exercise Science 18(7): 971-983, 2025. The total work completed during an exercise session is often assumed to be the primary factor influencing the kinetics of post-exercise recovery. However, the duration of work and rest periods during high intensity interval training (HIIT) have been shown to impact the magnitude of physiological stress and could also impact post-exercise recovery. The aim of this study was to characterize the recovery time course of neuromuscular function following work-to-rest matched HIIT protocols with different work interval durations and conducted to task failure. Participants (n=12, n=6 females) completed a ramp incremental exercise test …


Faculty Senate Agenda September 8, 2025, Utah State University Sep 2025

Faculty Senate Agenda September 8, 2025, Utah State University

Faculty Senate & Faculty Senate Executive Committee

  • 3:00 Call to Order
  • Approval of Minutes - April 28, 2025
  • 3:05 University Business
  • 3:20 Faculty Senate Business
  • 3:35 Information
  • EPC Report - April 3, 2025
  • The Office of Equity
  • 3:45 Report
  • Empowering Teaching Excellence
  • Center for Instructional Design and Innovation
  • 4:10 Old Business
  • 4:15 New Business
  • Adjourn: 4:30 pm


Education For Home Infusion Nurses, Ann Marie Wilson Sep 2025

Education For Home Infusion Nurses, Ann Marie Wilson

Walden Dissertations and Doctoral Studies

This document presents an executive summary of a staff education initiative designed for home infusion nurses, submitted in fulfillment of requirements for the Doctor of Nursing Practice at Walden University. The project aims to address the specialized educational needs of nurses in the home infusion setting, where evolving clinical procedures and patient safety standards demand advanced competency and knowledge. Through the development and implementation of targeted educational strategies, the project seeks to enhance nurses' skills, promote best practices in infusion therapy, and improve health outcomes for patients receiving infusion care at home. Key objectives include identifying gaps in current education, …


High Energy Consumption Characterizes Abnormal Brain State Transitions In Temporal Lobe Epilepsy, Sam S. Javidi, Qirui Zhang, Ankeeta Ankeeta, Michael R. Sperling, Joseph I. Tracy Sep 2025

High Energy Consumption Characterizes Abnormal Brain State Transitions In Temporal Lobe Epilepsy, Sam S. Javidi, Qirui Zhang, Ankeeta Ankeeta, Michael R. Sperling, Joseph I. Tracy

Farber Institute for Neuroscience Faculty Papers

Temporal lobe epilepsy (TLE) patients experience shifts between non-seizing and seizing brain states, but the structural networks underlying these transitions remain undefined and poorly characterized. We detected dynamic brain states in resting-state fMRI and constructed linked structural networks utilizing multi-shell diffusion-weighted MR data. Leveraging network control theory, we interrogated the structural data for all possible brain state transitions, identifying those requiring abnormal levels of transition energy (low or high) in TLE compared to matched healthy participants (n's = 25). Results revealed three transitions requiring significantly higher energy in TLE; no abnormally low-energy transitions were observed. In HPs, transitions relied on …


Bridging Domains: Advances In Explainable, Automated, And Privacy-Preserving Ai For Computer Science And Cybersecurity, Youssef Harrath, Oswald Adohinzin, Jihene Kaabi Dr., Morgan Saathoff Sep 2025

Bridging Domains: Advances In Explainable, Automated, And Privacy-Preserving Ai For Computer Science And Cybersecurity, Youssef Harrath, Oswald Adohinzin, Jihene Kaabi Dr., Morgan Saathoff

Research & Publications

Artificial intelligence (AI) is rapidly redefining both computer science and cybersecurity by enabling more intelligent, scalable, and privacy-conscious systems. While most prior surveys treat these fields in isolation, this paper provides a unified review of 256 peer reviewed publications to bridge that gap. We examine how emerging AI paradigms, such as explainable AI (XAI), AI-augmented software development, and federated learning, are shaping technological progress across both domains. In computer science, AI is increasingly embedded throughout the software development lifecycle to boost productivity, improve testing reliability, and automate decision making. In cybersecurity, AI drives advances in real-time threat detection and adaptive …


An Experiment In Electron Paramagnetic Resonance Spectroscopy For Undergraduate Labs In Physical Chemistry Or Physical Biochemistry, Evan A. Old, Matthew C. Rehak, Jefferson C. Thompson, Herbert J. Sipe Jr. Sep 2025

An Experiment In Electron Paramagnetic Resonance Spectroscopy For Undergraduate Labs In Physical Chemistry Or Physical Biochemistry, Evan A. Old, Matthew C. Rehak, Jefferson C. Thompson, Herbert J. Sipe Jr.

TeachEPR Submissions

We report a biochemically based EPR experiment for undergraduate laboratories that will serve as instruction for learning EPR sample preparation, spectral observation, and spectral analysis. There is a current lack of EPR instructional experiments that present complex spectra in which computational analysis may be required. The biochemical oxidation system of horse radish peroxidase (HRP) activated by H2O2 acts on 2,6-di-t-butyl-4-hydroxyanisole (DTBHA) to form phenoxyl radicals. This experiment produces moderately complex spectra of moderately long-lived radicals using relatively small amounts of readily available reactants. Spectrum analysis and simulation is accomplished using software freely available on-line. If desired, EPR …


Experiential Learning: Innovative Approaches To Post-Secondary Cybersecurity Education, Brendan Bertone, Paul Wagner, Joshua Pauli Sep 2025

Experiential Learning: Innovative Approaches To Post-Secondary Cybersecurity Education, Brendan Bertone, Paul Wagner, Joshua Pauli

Journal of Cybersecurity Education, Research and Practice

The cybersecurity profession continues to face a significant shortfall of qualified professionals despite steady growth in degree programs. Employers consistently cite experience as the main barrier for entry-level cybersecurity hires. This paper argues that clinic-based experiential learning offers a scalable solution to that preparation gap. A systematic literature review spanning academic and professional literature was conducted to examine: (1) barriers to entry for aspiring cybersecurity professionals; (2) the effectiveness of experiential learning compared to traditional instruction; and (3) the viability and scalability of cybersecurity clinics. Screening emphasized workforce development, experiential pedagogy, and alignment with the NICE Cybersecurity Workforce Framework. Findings …


Edce 32204_How Children Learn Math_Syllabus, Colleen O. Oppenzato Sep 2025

Edce 32204_How Children Learn Math_Syllabus, Colleen O. Oppenzato

Open Educational Resources

This course described by this syllabus will focus on the mathematical development and growth of children from birth through Grade 2, with an emphasis on preschool, kindergarten, Grade 1, and Grade 2.


A Scoping Review Of Epilepsy Care In Low-Resource Settings: Addressing Stigma, Healthcare Disparities, And Socioeconomic Barriers, Michael Mncedisi Willie Sep 2025

A Scoping Review Of Epilepsy Care In Low-Resource Settings: Addressing Stigma, Healthcare Disparities, And Socioeconomic Barriers, Michael Mncedisi Willie

Journal of Indonesian Health Policy and Administration

Epilepsy affects around fifty million people worldwide, with stigma and limited healthcare access posing significant challenges, especially in low-resource settings. This scoping review aimed to identify key barriers to epilepsy care, focusing on stigma, healthcare access, and socioeconomic factors in sub-Saharan Africa and similar contexts. Using the Arksey and O’Malley framework, a systematic search was conducted across online databases for peer-reviewed studies published. The review found that stigma significantly delayed diagnosis, increased social isolation, and reduced treatment adherence. Healthcare barriers included a lack of trained professionals and inadequate treatment protocols. Socioeconomic challenges, such as poverty and rural residency, were linked …


The Jokowi Effect On The Victory Of Prabowo: Do People Vote For Continuity?, Cakra Yudi Putra, Dyah Ayu Febriani, Andri Tantyo Cahyo Nugroho, Teguh Dartanto Sep 2025

The Jokowi Effect On The Victory Of Prabowo: Do People Vote For Continuity?, Cakra Yudi Putra, Dyah Ayu Febriani, Andri Tantyo Cahyo Nugroho, Teguh Dartanto

Economics and Finance in Indonesia

The 2024 Indonesian presidential election marked a striking realignment as Prabowo Subianto—a former opposition leader—secured victory with the tacit endorsement of outgoing President Joko Widodo (Jokowi). This study investigates how the enduring popularity and policy achievements of Jokowi shaped voter preferences in favor of Prabowo, effectively positioning the election as a referendum on political continuity. Building on theories of economic voting and retrospective performance evaluation, the analysis explores the impact of district-level economic indicators, social media penetration, ideological orientation, social assistance distribution, and sociocultural characteristics on electoral outcomes. Employing Ordinary Least Squares (OLS) regression on data from 481 administrative regions, …


The Basics Of The Mundlak And Chamberlain Projections, Badi H. Baltagi, Tom Wansbeek Sep 2025

The Basics Of The Mundlak And Chamberlain Projections, Badi H. Baltagi, Tom Wansbeek

Center for Policy Research

One of the best-known results in panel data econometrics, due to Mundlak (1978), is the equality of the random-effects and fixed-effects estimators when the individual effects are correlated with the means over time of the regressors. Chamberlain (1980) showed that the same result holds when the individual effects are correlated with the regressors for all moments in time separately. In this chapter, we review basic elements of the Mundlak and Chamberlain projections. We emphasize the simplicity that is often obtained when the model is transformed into the within and between-model, following Arellano (1993). Topics that we discuss include the augmented …


The Free Press Vol. 57, Issue 2, 09-08-2025, Julz Levesque, Caraline Squires Sep 2025

The Free Press Vol. 57, Issue 2, 09-08-2025, Julz Levesque, Caraline Squires

Free Press, The

ESPORTS Arena Opening--Will Susan Collins Lose?--MovieTalk and Events--World Cup in America--Letters from the Editors


Third Amended Plan Non-Monetary Terms Sep 2025

Third Amended Plan Non-Monetary Terms

Catholic Dioceses in Bankruptcy

No abstract provided.


Sex-Specific Associations Between Early Life Unpredictability And Trajectories Of Body Mass Index From Infancy To Adolescence, Emily M. Melnick, Lilybelle K. Deer, Jenalee R. Doom, Hal S. Stern, Curt A. Sandman, Laura M. Glynn, Elysia P. Davis Sep 2025

Sex-Specific Associations Between Early Life Unpredictability And Trajectories Of Body Mass Index From Infancy To Adolescence, Emily M. Melnick, Lilybelle K. Deer, Jenalee R. Doom, Hal S. Stern, Curt A. Sandman, Laura M. Glynn, Elysia P. Davis

Psychology Faculty Articles and Research

Objective:

Unpredictability in early life is an understudied aspect of early life adversity that provides important signals to the child about their environment. Recent work shows the predictability of patterns of parental signals on a moment-to-moment timescale sculpts the developing brain during sensitive windows, offering a potential pathway through which early life experiences shape child development. Both experimental non-human animal models and observational human research show sex-specific links between early life exposure to unpredictable patterns of parental sensory signals and aberrant offspring development. The impact of predictability of sensory signals on physical health outcomes, such as BMI, remains unknown. Here …


Tracing Carceral Continuities: A Review Of Recent Works On The Incarcerations Of The "Bhima Koregaon-16", Saumya Dadoo, Shailza Sharma Sep 2025

Tracing Carceral Continuities: A Review Of Recent Works On The Incarcerations Of The "Bhima Koregaon-16", Saumya Dadoo, Shailza Sharma

Socio-Legal Review

This systematic review analyses three recent books that focus on the incarceration of the “BK-16”—sixteen activists who were detained in the aftermath of a 2018 gathering to celebrate the bicentenary of the Battle of Koregaon: (1) Suchitra Vijayan and Francesca Recchia’s How Long Can the Moon Be Caged (Pluto Press 2023); (2) Alpa Shah’s The Incarcerations: Bhima Koregaon and the Search for Democracy in India (Harper Collins India 2024); and (3) Sudha Bharadwaj’s From Phansi Yard: My Year with the Women of Yerawada (Juggernaut 2023). The authors argue that, read together, the three works help situate the political and legal …


First-Generation College Students' Perceptions Of Undergraduate Degree Completion, Melinda Dianna Howard Sep 2025

First-Generation College Students' Perceptions Of Undergraduate Degree Completion, Melinda Dianna Howard

Walden Dissertations and Doctoral Studies

The problem explored in this study was the low graduation rate of first-generation college students at the university study site. Using Bandura’s self-efficacy theory, the purpose of this basic qualitative study was to explore first-generation college graduates’ beliefs about their educational experience as students upon entering a bachelor’s degree program, identify obstacles, and understand ways to master those obstacles to successfully graduate. Six first-generation college graduates from the study site were recruited from FIRST, an on-campus support organization, for semistructured interviews using purposeful sampling. Due to COVID and the closing of the university study site at the time of recruitment, …


Cyclical Matters: Black Labor, Temporality, And The Incomplete Reconstructions Within African American Literature, Courtney Walton Sep 2025

Cyclical Matters: Black Labor, Temporality, And The Incomplete Reconstructions Within African American Literature, Courtney Walton

Dissertations

This dissertation examines the role literature plays in understanding black life post-reconstruction and post-civil rights movement. Specifically, I explore the continuation of injustices and mistreatment for black workers, the role black labor plays during the first and second post-reconstructions, and how literature can be used in framing this discussion. The similarities between these periods help us to better understand the cycle of racist societal expectations and the challenges black workers face integrating into society, discriminatory mandates required of black workers, the unfair job market, and forced labor. These periods interact cyclically in that the second post-reconstruction models the first post-reconstruction. …


Give People Money: The Effect Of Perceived Inequality In Everyday Life And Previous Cash-Transfer Programs On Support For Universal Basic Income, David Thomas Igliozzi Sep 2025

Give People Money: The Effect Of Perceived Inequality In Everyday Life And Previous Cash-Transfer Programs On Support For Universal Basic Income, David Thomas Igliozzi

Dissertations

Economic inequality is a global concern with many adverse consequences for people across class divides. These consequences vary in scope—from negative effects on individual’s physical, mental, and social health to large-scale economic shifts which result from climate change (Galbraith & Hale, 2008; Hiesh & Pugh, 1993; Kaplan et al., 1996; La Ferrara & Alesina, 2000; Solt, 2008; Vilhjalmsdottir et al., 2016; Wilkinson & Pickett, 2007). Policy solutions meant to address the negative effects of economic inequality include government redistribution of wealth. Universal Basic Income (UBI), a specific and actionable policy of government redistribution, is a promising method of economic inequality …


“The Wonderful Swiftness Of The Soul”: Mental Movement And Religious Ethics In Medieval English Literature, Abigail Palmisano Sep 2025

“The Wonderful Swiftness Of The Soul”: Mental Movement And Religious Ethics In Medieval English Literature, Abigail Palmisano

Dissertations

This dissertation analyzes conceptual metaphors of psychological motion and stability in medieval English religious literature. I trace how language itself structures cultural approaches to epistemology, spiritual knowing, and virtue. Chapter One examines Alfred’s translation of Neoplatonic metaphors of psychological movement in the OE translations of The Consolation of Philosophy and Augustine’s Soliloquies. I argue that the reconfiguration of these metaphors into images of stability reveals an epistemology centered on certainty. Chapter Two compares the omission of motive psychological metaphor in Cynewulf’s Juliana and Ælfric’s “St. Agatha and St. Lucy” in process of translation. While Cynewulf’s depiction of virtue through stability …


The Invisibility Of Race In Brazilian Jiu Jitsu: The Gracies Versus Capoeira And Judo, Benjamin Penglase Sep 2025

The Invisibility Of Race In Brazilian Jiu Jitsu: The Gracies Versus Capoeira And Judo, Benjamin Penglase

Anthropology: Faculty Publications and Other Works

This research article examines why the racialization of Brazilian jiu-jitsu has so often been invisible to non-Brazilians. It argues that Brazilian jiu-jitsu emerged in a highly racially stratified context and looks in particular at challenge matches that the Gracie family engaged in with fighters who practiced capoeira or judo.  It argues that through these competitions, not only was Brazilian jiu-jitsu located within Brazil’s racial hierarchy, but it was often positioned as ‘white,’ though usually in an unspoken manner. The ‘invisibility’ of Brazilian jiu-jitsu’s racialization is connected to Brazil’s hegemonic racial system where race is both of central social importance, yet …


Defining Breast Epithelial Cell Types In The Single-Cell Era, G Kenneth Gray, Eric G Carlson, Tatyana Lev, Bailey Marshall, Austin D Reed, Alex P Sánchez-Covarrubias, Alecia-Jane Twigger, Aleix Puig-Barbe, Aatish Thennavan, Ayodele Omotoso, Lyndsay M Murrow, Deeptiman Chatterjee, Siyuan He, Sara Pensa, Brian Aevermann, Norbert K Tavares, Natalie Chen, Jason A Hilton, Kerrigan Blake, Yunlong Liu, Kiet Phong, Zev J Gartner, Devon A Lawson, Alexander Swarbrick, Camila O Dos Santos, Sophia H L George, Joan S Brugge, Mark A Labarge, Harikrishna Nakshatri, Nicholas Navin, Kai Kessenbrock, Walid T Khaled Sep 2025

Defining Breast Epithelial Cell Types In The Single-Cell Era, G Kenneth Gray, Eric G Carlson, Tatyana Lev, Bailey Marshall, Austin D Reed, Alex P Sánchez-Covarrubias, Alecia-Jane Twigger, Aleix Puig-Barbe, Aatish Thennavan, Ayodele Omotoso, Lyndsay M Murrow, Deeptiman Chatterjee, Siyuan He, Sara Pensa, Brian Aevermann, Norbert K Tavares, Natalie Chen, Jason A Hilton, Kerrigan Blake, Yunlong Liu, Kiet Phong, Zev J Gartner, Devon A Lawson, Alexander Swarbrick, Camila O Dos Santos, Sophia H L George, Joan S Brugge, Mark A Labarge, Harikrishna Nakshatri, Nicholas Navin, Kai Kessenbrock, Walid T Khaled

Faculty, Staff and Student Publications

Single-cell studies on breast tissue have contributed to a change in our understanding of breast epithelial diversity that has, in turn, precipitated a lack of consensus on breast cell types. The confusion surrounding this issue highlights a possible challenge for advancing breast atlas efforts. In this perspective, we present our consensus on the identities, properties, and naming conventions for breast epithelial cell types and propose goals for future atlas endeavors. Our proposals and their underlying thought processes aim to catalyze the adoption of a shared model for this tissue and to serve as guidance for other investigators facing similar challenges.


Increased Risk Of Postoperative Complications In Patients With Hypertension Undergoing Mohs Micrographic Surgery, Alexandra Elder, Henry Yang, Megan O'Donnell-Capelli, Jenna Mandel, Molly Wallace, Lauren Banner, Ramsay Hafer, Thomas Rohan, Neda Nikbakht Sep 2025

Increased Risk Of Postoperative Complications In Patients With Hypertension Undergoing Mohs Micrographic Surgery, Alexandra Elder, Henry Yang, Megan O'Donnell-Capelli, Jenna Mandel, Molly Wallace, Lauren Banner, Ramsay Hafer, Thomas Rohan, Neda Nikbakht

Department of Dermatology and Cutaneous Biology Faculty Papers

Hypertension has been previously associated with higher intraoperative bleeding risk in patients undergoing Mohs micrographic surgery. However, the risks of common postoperative Mohs micrographic surgery complications have not been substantiated by large studies. Our study aimed to assess the risks of common Mohs micrographic surgery complications for patients with hypertension utilizing the TriNetX database, a global health records database encompassing over 105 million patients' data, from January 2009 to January 2024. After 1:1 propensity score matching for age, sex, race, diabetes, nicotine dependence, obesity, and anticoagulant use, the final analysis included 80,739 patients in each cohort of patients with hypertension …


Analysis Of Health Policy Impacts On Adolescent Tobacco And Alcohol Consumption In Asean: An Ecological Descriptive Study, Marzalyla Putri Hendriansyah, Syifa Azzahra Setiawan, Sabrina Aprilia Putri, Falah Nur Chusniati, Rizka Maulida Sep 2025

Analysis Of Health Policy Impacts On Adolescent Tobacco And Alcohol Consumption In Asean: An Ecological Descriptive Study, Marzalyla Putri Hendriansyah, Syifa Azzahra Setiawan, Sabrina Aprilia Putri, Falah Nur Chusniati, Rizka Maulida

Journal of Indonesian Health Policy and Administration

The prevalence of tobacco and alcohol consumption among adolescents in Southeast Asia remains a public health concern despite the introduction of several national policies. This study assessed the relationship between policy implementation and consumption trends of tobacco and alcohol in selected ASEAN countries. Using a descriptive ecological design, we analyzed secondary data from the Global School-based Student Health Survey (GSHS) and policy documents from official government sources. We observed a rise in tobacco consumption in Indonesia (+4.2%) and Brunei (+5.5%), while Thailand experienced a slight increase (+0.3%). Conversely, alcohol consumption decreased marginally in Indonesia (-0.7%) and Brunei (-0.8%), but increased …


Lanthorn, Vol. 60, No. 03, September 8, 2025, Grand Valley State University Sep 2025

Lanthorn, Vol. 60, No. 03, September 8, 2025, Grand Valley State University

Volume 60, August 4, 2025 – April 20, 2026

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.


Gene Context Drift Identifies Drug Targets To Mitigate Cancer Treatment Resistance, Amir Jassim, Birgit V Nimmervoll, Sabrina Terranova, Erica Nathan, Linda Hu, Jessica T Taylor, Katherine E Masih, Lisa Ruff, Matilde Duarte, Elizabeth Cooper, Gunjan Katyal, Melika Akhbari, Reuben J Gilbertson, Jennifer C Coleman, Joseph S Toker, Colton Terhune, Gabriel Balmus, Stephen P Jackson, Hailong Liu, Tao Jiang, Michael D Taylor, Kui Hua, Jean E Abraham, Mariella G Filbin, Anthony Hill, Anarita Patrizi, Neil Dani, Aviv Regev, Maria K Lehtinen, Richard J Gilbertson Sep 2025

Gene Context Drift Identifies Drug Targets To Mitigate Cancer Treatment Resistance, Amir Jassim, Birgit V Nimmervoll, Sabrina Terranova, Erica Nathan, Linda Hu, Jessica T Taylor, Katherine E Masih, Lisa Ruff, Matilde Duarte, Elizabeth Cooper, Gunjan Katyal, Melika Akhbari, Reuben J Gilbertson, Jennifer C Coleman, Joseph S Toker, Colton Terhune, Gabriel Balmus, Stephen P Jackson, Hailong Liu, Tao Jiang, Michael D Taylor, Kui Hua, Jean E Abraham, Mariella G Filbin, Anthony Hill, Anarita Patrizi, Neil Dani, Aviv Regev, Maria K Lehtinen, Richard J Gilbertson

Faculty, Staff and Students Publications

Cancer treatment often fails because combinations of different therapies evoke complex resistance mechanisms that are hard to predict. We introduce REsistance through COntext DRift (RECODR): a computational pipeline that combines co-expression graph networks of single-cell RNA sequencing profiles with a graph-embedding approach to measure changes in gene co-expression context during cancer treatment. RECODR is based on the idea that gene co-expression context, rather than expression level alone, reveals important information about treatment resistance. Analysis of tumors treated in preclinical and clinical trials using RECODR unmasked resistance mechanisms -invisible to existing computational approaches- enabling the design of highly effective combination treatments …


Results Of Tor001: An Open-Label Single Patient Study Using Targeted Bacteriophage Therapy For The Treatment Of A Chronic Urinary Tract Infection, Jonathan D Cook, Payton B Hooey, Keiko C Salazar, Justin R Clark, Umesh Jain, Carlos Fernando, Hanjeong Harvey, Alexander Cervantes, Stephanie Omagari, Udi Blankstein, Andrew M Kropinski, Alan R Davidson, Karen L Maxwell, Lori L Burrows, Austen L Terwilliger, Anthony W Maresso, Greg J German Sep 2025

Results Of Tor001: An Open-Label Single Patient Study Using Targeted Bacteriophage Therapy For The Treatment Of A Chronic Urinary Tract Infection, Jonathan D Cook, Payton B Hooey, Keiko C Salazar, Justin R Clark, Umesh Jain, Carlos Fernando, Hanjeong Harvey, Alexander Cervantes, Stephanie Omagari, Udi Blankstein, Andrew M Kropinski, Alan R Davidson, Karen L Maxwell, Lori L Burrows, Austen L Terwilliger, Anthony W Maresso, Greg J German

Faculty, Staff and Students Publications

Chronic urinary tract infections are persistent bacterial infections with the potential to drive antibiotic resistance. Like other persistent bacterial infections, intracellular bacterial reservoirs and biofilm formation hinder the clearance of pathogens despite long courses of antibiotic therapy. New strategies for treatment of these persistent infections are needed. Here we describe the results of an open-label individual patient study using bacteriophage therapy to treat a chronic urinary tract infection in an immunocompetent 72-year-old woman without underlying urolithiasis or indwelling devices. We co-administered HP3.1, HP3, and ES19 bacteriophages with demonstrated in vitro activity via bladder instillation, orally, and as a topical formulation. …