Digital Commons Network^™

Financial Shocks, Emergency Savings, And Hardship Among Low-Wage Workers, Haotian Zheng, Stephen Roll, Mathieu Despard

Center for Social Development Research

For many households, particu­larly those with limited income or financial resources, medical emergencies, car repairs, sudden job losses, and unexpected expenses can quickly precipitate financial hardships. Emergency savings provide a buffer that allows households to manage disrup­tions and avoid reliance on options that incur high-interest debt. Addressing the lack of emergency savings is not just a matter of individual responsibility; it also poses a broader policy challenge with implications for public welfare. Drawing upon data from the nationally representative Workforce Economic Inclusion and Mobility survey, this brief reports on low-wage households’ experiences with shocks, savings, and hardships. It also discusses …

The Meaning Of Christian Suffering In Aquinas, Pedro Cardoso Figueiredo Santiago

Seton Hall University Dissertations and Theses (ETDs)

This thesis investigates the theological meaning of Christian suffering in the thought of Thomas Aquinas. While much attention has been given to Aquinas’s treatment of the problem of evil, little has been written on the positive and salvific meaning of suffering as it appears in his Christology, sacramental theology, and moral theology. This study aims to demonstrate that for Aquinas, suffering—when united to Christ—acquires a redemptive value that transforms human pain into a means of configuration to the crucified and risen Lord.

The first chapter develops the Christological foundation of Christian suffering. Drawing primarily from Summa Theologiae III, q. 69, …

Modeling Musculoskeletal Combat Casualty Care: Nato Trauma System Performance In Large Scale Combat Operations, Mark P. Cote, Kaitlyn E. Holly, Roman J. Schoenfeld, Matthew R. Bryan, Malina O. Hatton, Mitchel B. Harris, Tracey P. Koehlmoos, Andrew J. Schoenfeld

Department of Orthopaedic Surgery Faculty Papers

BACKGROUND: It is unclear whether the current North Atlantic Treaty Organization (NATO) trauma system will be effective in the setting of Large-Scale Combat Operations (LSCO). We sought to model the efficacy of the NATO trauma system in the setting of LSCO. We also intended to model novel scenarios that could better adapt the current system to LSCO.

METHODS: We developed a discrete-event simulation model for patients with combat musculoskeletal injuries treated within the standard NATO system. The primary outcome of the model was survival. The model's health states were characterized as stable, hypovolemia, sepsis, shock, or death. The model simulated …

The Colonic Crypt: Cellular Dynamics And Signaling Pathways In Homeostasis And Cancer, Anh L. Nguyen, Molly A. Lausten, Bruce M. Boman

College of Life Sciences Faculty Papers

The goal of this review is to expand our understanding of how the cellular organization of the normal colonic crypt is maintained and elucidate how this intricate architecture is disrupted during tumorigenesis. Additionally, it will focus on implications for new therapeutic strategies targeting Epithelial-Mesenchymal Transition (EMT). The colonic crypt is a highly structured epithelial unit that functions in maintaining homeostasis through a complex physiological function of diverse cell types: SCs, transit-amplifying (TA) progenitors, goblet cells, absorptive colonocytes, Paneth-like cells, M cells, tuft cells, and enteroendocrine cells. These cellular subpopulations are spatially organized and regulated by multiple crucial signaling pathways, including …

An Adaptive Force Matching Potential For Alanine Developed With Møller-Plesset Perturbation Theory And Smooth Fourier Transform Correction Map, Ying Yuan, Feng Wang

Chemistry & Biochemistry Faculty Publications and Presentations

Developing accurate force fields for biomolecules remains a significant challenge due to the subtle energetic differences between various conformational states. We present a novel force field model for polyalanine, ALAMP2_25, developed using adaptive force matching (AFM) with M & oslash;ller-Plesset perturbation theory at the second order (MP2) as the reference method. By fitting smaller model compounds and transferring parameters to larger peptides, we overcome the limitations of traditional AFM approaches and enable the use of more accurate electronic structure methods. The ALAMP2_25 model incorporates a new correction scheme, Smooth Fourier Transform-based phi, psi correction map (SFT-CMAP), which efficiently describes phi, …

Exploring The Influence Of Leadership On The Organizational Performance Of Federally Qualified Health Centers In The United States Through The Lens Of The Upper Echelons Theory, Devdutt Shriram Upadhye

All ETDs from UAB

This study examines the influence that leaders have on the performance of Federally Qualified Health Centers (FQHCs) in the US. The framework through which the study examines this relationship is the Upper Echelons Theory (UET), which posits that managers and leaders take actions that shape the organization they lead, and these actions are based on a confluence of experiential and characteristic factors. The current study focuses on a leader’s influence through three proxies, viz. educational background, role tenure, and sex, on the organizational performance of FQHCs. Performance is captured using both financial and quality metrics. Data for the study was …

A Short Trip: A Mixed Methods Investigation Of The Perceived Effects Of Vaporized Dmt Vs Vaporized 5-Meo-Dmt, Cynthia Estrella Ortiz

All ETDs from UAB

The rise in psychedelic use has been accompanied by increased interest in alternative routes of administration, including vaporization. However, little is known about the characteristics and outcomes associated with vaporized forms of N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT). This mixed-methods study examined the subjective experiences and mental health correlates of individuals who reported using vaporized DMT, vaporized 5-MeO-DMT, or psilocybin mushrooms in the past six months. A total of 209 adults completed an online survey assessing demographic variables, substance use, and psychological functioning, including measures of global health (PROMIS), subjective happiness, magical ideation, spiritual connection, psychosis-like experiences (CAPE-42), and hypomanic symptoms. …

Bridging Fact And Fiction: Lawrence Alma-Tadema’S And Georg Ebers’ Visions Of Ancient Egypt, Elizabeth Casement

All ETDs from UAB

Existing research on the methodology behind the production of ancient Egyptian-themed paintings of Lawrence Alma-Tadema (1836-1912) has centered on his use of an extensive cache of reference materials. This thesis suggests that Alma-Tadema’s sources of historical information and creative influence far exceeded his private reference library, also hinging on his vast personal network and specifically examining the collaborative friendship he maintained with German author and professor of Egyptian studies Georg Ebers (1837-1898). A thorough reading of letters from Alma-Tadema to Ebers elucidates the impact of the German author on the artist’s understanding of Egypt from the Pharaonic to the Roman …

Measuring Emotional Well-Being Across Neurodevelopmental Disorders, Alecia Mercier

All ETDs from UAB

Emotional well-being has emerged as a crucial determinant of both physical and mental health, with implications for public health initiatives aimed at improving quality of life and reducing mortality. However, a clear and consistent understanding of emotional well-being, its components, and optimal measurement strategies remains lacking, especially for individuals with neurodevelopmental disorders. This dissertation investigated how emotional well-being is conceptualized and measured in individuals with neurodevelopmental disorders. Paper one was a scoping review that identified 20 emotional well-being measures developed or adapted for individuals with intellectual and developmental disabilities. Findings demonstrated that many existing measures do not include emotional well-being …

Bayesian Mediation Analyses For Zero-Inflated Data, Jinhong Cui

All ETDs from UAB

Mediation analysis is a fundamental tool in causal inference, enabling researchers to disentangle the pathways through which an exposure affects an outcome via intermediate variables (mediators). It has been widely applied in social sciences, psychology, and healthcare-related studies. Traditionally, mediation analysis has been conducted within the linear structural equation modeling (LSEM) framework. However, recent advances have shifted attention toward the counterfactual framework due to its flexibility in defining causal effects and its capacity to accommodate non-linear relationships, parametric and non-parametric models. Building on this foundation, methodological developments in mediation analysis have expanded to address more complex data structures, such as …

Voices From Two Secondary Newcomer Programs In Alabama: A Multiple Case Study, Carl Anthony Floyd Jr

All ETDs from UAB

This multiple case study investigates the design, implementation, and impact of two secondary newcomer programs in Alabama, with a focus on Students with Limited or Interrupted Formal Education (SLIFE) and non-SLIFE English Learner (EL) newcomers. Grounded in Esteban-Guitart et al.’s (2023) framework of community funds of knowledge and identity, the study explores how these programs function as community educational ecosystems. Data were collected through interviews, observations, and document reviews across two school districts and analyzed using ethnographic and thematic methods. Findings reveal that when newcomer programs are intentionally designed to leverage community assets and cultural identities, they provide meaningful academic, …

Parenting And Parental Well-Being As Risk And Resilience Factors For Mental Well-Being In Adolescents With And Without Neurodevelopmental Disorders, Wanqin Yu

All ETDs from UAB

Parenting practices and caregiver well-being are widely recognized as key determinants of adolescent mental health. However, few studies have examined how these factors operate in the context of neurodevelopmental disorders (NDDs), particularly through a risk and resilience framework. This study investigated how positive and negative parenting practices, caregiver well-being, and parenting stress relate to adolescents’ emotional well-being and internalizing problems. It also explored whether these variables differed between adolescents with and without NDDs. Participants included 105 adolescents aged 11–14 years (61.9% female; 52.4% diagnosed with an NDD) and their caregivers, drawn from a larger study on adolescent socio-emotional competencies. Caregivers …

Evaluating Relative Value Units And Its Alternatives Inradiology, Alfred Matthew Dewey

All ETDs from UAB

ABSTRACT Radiologist productivity in the United States is traditionally measured by thework Relative Value Unit (wRVU). However, wRVUs fail to capture several criticalaspects of radiologic work, including study complexity, patient characteristics, andfacility factors. This study evaluated the statistical significance of wRVUs as a measureof productivity and proposes an alternative model grounded in ascribable time—themeasurable duration a radiologist takes to interpret and report a study.A comprehensive literature review highlighted the inadequacy of wRVUs inaccounting for technological advances, case complexity, and workflow differences.Applying contingency theory as the guiding framework, this study posited that radiologyproductivity must be tailored to institutional and contextual variability. …

Mesenchymal Stem Cells In Socket Healing And Mronj, Yuki Arai, Chiaki Tsutsumi-Arai, Jeryl D English, Noriaki Ono, Wanida Ono

Faculty, Staff and Student Publications

This review aims to summarise the current understanding of the biological processes involved in socket healing after tooth extraction and the contribution of mesenchymal stem/progenitor cells (MSCs) during these processes. Additionally, it seeks to explore the mechanisms underlying medication-related osteonecrosis of the jaw (MRONJ), often linked to tooth extraction, to provide insights for future research directions. Socket healing is a complex biological process consisting of three phases: inflammatory, proliferative and modelling/remodelling. MSCs, particularly those derived from periodontal ligament (PDL) cells and bone lining cells, are known to play a significant role in the initial and subsequent stages of healing. However, …

The Glutaminase Activity Of Asns Fuels Glutamine Metabolism In Leukemia, Wai-Kin Chan, Lin Tan, Sara A Martinez, Di Du, Thomas D Horvath, Michael Pontikos, Leona A Rusling, Yulun Chiu, Bao Q Tran, Susan B Rempe, Sergei Sukharev, John N Weinstein, Philip L Lorenzi

Faculty, Staff and Student Publications

Not available.

Randomized Control Trial Of A Novel Dental Gel As An Adjunct To Scaling And Root Planing In Subjects With Stage Ii & Iii Periodontitis, Efstratios Choreftakis

All ETDs from UAB

Scaling and root planing (ScRP) is the gold standard for non-surgical periodontal therapy, yet no dentifrice has been definitively shown to improve its outcomes. This randomized controlled trial evaluated the effectiveness of LivFresh Dental Gel as an adjunct to ScRP in patients with Stage II and III periodontitis. Twenty-one participants were assigned to either a test group using LivFresh Dental Gel or a control group using a standard sodium fluoride dentifrice. Clinical parameters—including probing depth (PD), clinical attachment level (CAL), gingival index (GI), plaque index (PI), and bleeding on probing (BOP)—were assessed at baseline, 30, 90, and 180 days. The …

Racial Discrimination And Inflammation In Adolescence: Ethnic/Racial Processes As Moderators, Queenisha Crichlow

All ETDs from UAB

Discrimination and other psychosocial stressors contribute to chronic disease by dysregulating neuroendocrine and immune systems, which often leads to increased levels of inflammation. Given that inflammation is a key biological pathway associated with the development of chronic diseases, it has been proposed as a potential mechanism linking racial discrimination to poorer health. Most studies linking racial discrimination with inflammation have focused on adults, despite the fact that children and adolescents also experience discrimination. This dissertation explores the association between racial discrimination and inflammation, measured via salivary C-reactive protein (CRP) and proinflammatory cytokines, among Black and Hispanic adolescents. It also examines …

Impact Of Alpha-Synuclein Aggregation On Corticostriatal Synaptic Function And Morphology, Charlotte Franziska Brzozowski

All ETDs from UAB

Lewy Body Dementias (LBDs), including Parkinson’s Disease Dementia (PDD) and Dementia with Lewy Bodies (DLB), are defined by α-synuclein (α-syn) accumulation in Lewy Pathology (LP). LP is abundant in cortical layer V intratelencephalic (IT) neurons, a subset of neurons that also degenerate in the pre-supplementary motor area (preSMA) in humans, which is homologous to the secondary motor cortex (M2) in mice, as observed in PD postmortem tissue. IT neuron projections to the striatum are an intrinsic part of the motor basal ganglia circuitry, believed to modulate cognitive aspects of executive motor control, such as updating motor plans. M2 projections to …

The Association Of Resilience Factors With Mental Health Outcomes Among Middle-Aged And Older People Living With Hiv, Jeremy Delgadillo

All ETDs from UAB

Research suggests that people living with HIV (PLWH), an aging chronic health population, have higher prevalence rates and severity of mental health and substance use disorders compared to people living without HIV (PLWoH). Cross-sectional and longitu-dinal studies have suggested intrapersonal resilience factors may serve a protective function in reducing the prevalence and severity of mental health and substance use outcomes among PLWH. The purpose of the current study was two-fold. The first aim was to systematically review the current state of the literature from 2000 to present that examined the associations between intrapersonal resilience factors and mental health outcomes among …

Those Who Strayed: Quaker Abolitionist John Greenleaf Whittier, And The Grimké Sisters Who Broke From The Society Of Friends To Actively Oppose Slavery In The Antebellum Era, David Mark Ledlow

All ETDs from UAB

The adoption of quietist theology by the Quaker community in the early nineteenth century created a divide between Quakers and their abolitionist movement due to the differing methods to achieve an end to slavery. Quaker society began to adopt a stance that avoided all controversies and employed conservative actions to combat slavery while abolitionist began to speak out more against the evils of slavery regardless of any controversy. This divided left Quaker abolitionist like John Greenleaf Whittier and the Grimké sisters with the choice to distance themselves from the Society of Friends or the abolitionist movement. Whittier and the Grimké …

Reducing The Risk Of Phishing Attacks Through Providing Consistent Training Via The Kaizen Education Platform, Dalton E. Pena

All ETDs from UAB

Introduction: Many healthcare organizations have experienced cybersecurity related phishing email attacks, costing these organizations many thousands to many millions of dollars to release ransomed data to maintain patient care delivery and operations. Use of technology alone has proven to be insufficient, as most occurrences of data breaches are related to human behaviors. Background: Cybersecurity is a threat increasingly common to healthcare organizations, and it is gaining in both sophistication and complexity, aided by artificial intelligence. Healthcare organizations have adopted new technologies and increased the prevalence of cybersecurity training to develop a healthy cyber culture and construct a human firewall against …

Spartan Daily, September 11, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 165, Issue 9

Nmr-Based Metabolomic Profiling For Brain Cancer Diagnosis And Treatment Guidance, Julia R Zickus, José S Enriquez, Paytience Smith, Bill T Sun, Muxin Wang, Aldo Morales, Pratip K Bhattacharya, Shivanand Pudakalakatti

Faculty, Staff and Student Publications

Nuclear magnetic resonance (NMR) spectroscopy is a routinely used analytical tool for studying chemical entities of varying molecular sizes, ranging from approximately 20 Da to ~45 kDa, and in some cases even larger. Over the past two decades, the use of NMR spectroscopy has significantly expanded to the study of metabolomics. In this medium-sized review, the application of NMR-based metabolomics in the diagnosis, therapeutic intervention, and guidance of therapy for various types of brain cancer is discussed.

Complete Genome Sequence Of Actinomyces Oris Strain Mg-1: An Oral Commensal Critical For Dental Plaque Formation, Bibek G C, Kexin Tan, Chenggang Wu

Faculty, Staff and Student Publications

Actinomyces oris MG-1 is a key oral commensal involved in dental plaque formation. We report its complete genome sequence, generated using Illumina and Oxford Nanopore sequencing. The genome consists of a single circular chromosome of 3,042,829 bp, providing a resource for future functional studies.

Neuroengineering Approaches Assessing Structural And Functional Changes Of Motor Descending Pathways In Stroke, Jordan N Williamson, Rita Huan-Ting Peng, Joohwan Sung, Mahmood Rajabtabar Darvish, Xiaoxi Chen, Mehreen Ali, Sheng Li, Yuan Yang

Faculty, Staff and Student Publications

Stroke is a leading cause of adult disability worldwide, with approximately 101 million survivors globally. Over 60% of these individuals live with from long-term, often lifelong, movement impairments that significantly hinder their ability to perform essential daily activities and maintain independence. Post-stroke movement disabilities are highly associated with structural and functional changes in motor descending pathways, particularly the corticospinal tract and other indirect motor pathways via the brainstem. For decades, neuroengineers have been working to quantitively evaluate the post-stroke changes of motor descending pathways, aiming to establish a precision prognosis and tailoring treatments to post-stroke motor impairment. However, a clear …

Ubiquitination-Targeted Therapies Improve Bmd Ipsc Myogenic Cell Engraftment And Dystrophin Expression In Vivo, Muchen Liu, Somik Chatterjee, Jianbo Wu, Zeinab Kashaniasl, Ashok Kumar, Chunru Lin, Radbod Darabi

Faculty, Staff and Student Publications

Becker muscular dystrophy (BMD) is caused by in-frame mutations in dystrophin gene, leading to progressive muscle weakness, and cardiac and respiratory complications. Currently, there is no cure. We have recently identified the importance of poly-ubiquitination in regulating dystrophin stability through the binding of lncRNA H19 to the dystrophin C-terminal zinc-finger domain (ZNF), inhibiting TRIM63-mediated poly-ubiquitination. We also demonstrated that BMD mutations lead to conformational changes in ZNF domain, reduced lncRNA H19 binding and increased dystrophin ubiquitination. Here we used BMD iPSCs to investigate the in vitro myogenic potential of BMD myogenic cells, as well as in vitro and in vivo …

Neurotransmitter Signaling In Molecular And Behavioral Immune Responses To Pathogens In C Elegans, Benson Otarigho, Alejandro Aballay

Faculty, Staff and Student Publications

Neurotransmitter signaling pathways play major roles in both molecular and behavioral defenses against pathogen invasion, shaping the ability of Caenorhabditis elegans to sense and respond to environmental challenges. Given the conservation of neurotransmitter signaling pathways, their understanding may not only provide insights into the neurobiology of C. elegans but also has broader implications for our understanding of neural-immune interactions and host defense mechanisms in higher organisms. In this review, we discussed the literature on various neurotransmitter signaling pathways, including serotonergic, dopaminergic/octopaminergic, GABAergic, and glutamatergic pathways, and how these pathways modulate molecular and behavioral immune defense against pathogens.

From Model To Behavior: Methodological Challenges In Using Fuzzy Cognitive Maps To Represent Mental Models, Catherine Elizabeth Moore

Dissertations and Theses

This dissertation examines the use of Fuzzy cognitive maps (FCMs) as representations of mental models and how these representations connect to individual behavior. Fuzzy cognitive maps (FCMs) are semi-quantitative models that encode cause-and-effect structures as directed graphs. They are frequently used to represent individuals' knowledge structures/mental models and should in theory correlate to actions and decisions of individuals; however, this correlation has yet to be explored in a systematic manner. This dissertation represents the first step in experimental research on the connection between FCMs and individual behavior. It examines two theories of how humans use mental models, one based on …

Mechanistic Rationale For Toxic Aerosol Formation From Vaping And Dabbing With A Focus On Ketene Formation From Semi-Synthetic Cannabinoids, Kaelas Ryan Munger

Dissertations and Theses

Cannabis vaping is a relatively new route of administration that is increasingly common among youth and young adults. Cannabis vaping has been associated with cases of acute lung injury, especially among youth, and most often involves the heating and aerosolization of high-potency products having cannabinoid concentrations of ~ 50 % - 98 % w/w. Proponents argue that vaping is safer than smoking due to the characteristically lower temperatures and fewer plant materials. However, the extreme cannabinoid concentrations, along with non-natural formulations having undisclosed additives, require studies of the health effects of these products. Despite the popularity of cannabis concentrate vaping, …

Barriers And Timely Postoperative Radiation Therapy In Head And Neck Cancer, Megan T Nguyen, Emily Kistner-Griffin, Reid Demass, Bhisham S Chera, Chanita Hughes Halbert, Katherine R Sterba, Elizabeth G Hill, Brian Nussenbaum, Anthony J Alberg, Vlad C Sandulache, David J Hernandez, Ryan S Jackson, Sidharth V Puram, Russel Kahmke, Nosayaba Osazuwa-Peters, Gail Jackson, Sue S Yom, Evan M Graboyes

Faculty, Staff and Students Publications

Importance: Initiation of postoperative radiation therapy (PORT) within 6 weeks of surgery is associated with improved outcomes among patients with head and neck squamous cell carcinoma. However, the relationship of barriers to care with timely PORT is unknown.

Objective: To categorize barriers to timely PORT, evaluate the association of barriers to care with initiation of timely PORT, and describe the primary reason for delay among patients without timely PORT.

Design, setting, and participants: This prospective cohort study at a US academic medical center included adults with head and neck squamous cell carcinoma undergoing curative-intent surgery with an indication for PORT. …