Digital Commons Network^™

Efficacy Of Erdafitinib Before Or After Enfortumab Vedotin In Fgfr3-Altered Advanced Urothelial Cancer: Analysis Of The Unite Collaborative Study, Cindy Y Jiang, Hyunsoo Hwang, Ilana Y Epstein, Dimitra Rafailia Bakaloudi, Rafee Talukder, Amy K Taylor, Amanda Nizam, Tanya Jindal, Michael J Glover, Ali Raza Khaki, Pedro C Barata, Charles B Nguyen, Eugene Oh, Nancy B Davis, Hannah Mabey, Christopher J Hoimes, Sean T Evans, Bashar Abuqayas, Emily Lemke, Irene Tsung, Wei Qiao, Deepak Kilari, Yousef Zakharia, Mehmet A Bilen, Matthew I Milowsky, Sumit A Shah, Shilpa Gupta, Hamid Emamekhoo, Joaquim Bellmunt, Ajjai S Alva, Petros Grivas, Pavlos Msaouel, Vadim S Koshkin, Matthew T Campbell, Omar Alhalabi

Faculty, Staff and Students Publications

Background: Erdafitinib is approved for locally advanced/metastatic urothelial cancer (LA/mUC). As enfortumab vedotin (EV) plus pembrolizumab enters frontline management, outcomes with erdafitinib pre- and post-EV are clinically relevant but not specifically evaluated in clinical trials.

Methods: UNITE is a multi-institutional retrospective study of patients with LA/mUC treated with novel targeted agents. All patients with FGFR3 alterations treated with EV only, erdafitinib then EV (Erda->EV), and EV then erdafitinib (EV->Erda) were included. Sequential treatment with EV and Erda was not required. Primary endpoints were observed response rates (ORR) and progression-free survival (PFS); secondary endpoint was overall survival (OS).

Results: …

Impact Of Obicetrapib On Major Adverse Cardiovascular Events In High-Risk Patients: A Pooled Analysis, Stephen J Nicholls, Adam J Nelson, Kausik K Ray, Christie M Ballantyne, Marc Ditmarsch, Douglas Kling, Andrew Hsieh, Michael Szarek, John J Kastelein, Michael H Davidson

Faculty, Staff and Students Publications

Background: The cholesteryl ester transfer protein inhibitor obicetrapib decreases levels of atherogenic lipids and raises high-density lipoprotein cholesterol (HDL-C).

Objectives: In this study, we sought to determine the effect of obicetrapib on cardiovascular events.

Methods: The effects of 10 mg obicetrapib and placebo daily on major adverse cardiovascular event (MACE) rates were investigated in a pooled analysis of 354 patients with heterozygous familial hypercholesterolemia (HeFH) and 2,530 patients with atherosclerotic cardiovascular disease (ASCVD) over 365 days. The association between on-treatment lipids and MACE were also investigated.

Results: The cohort (mean age 66 years, 36% female, ASCVD 82%, HeFH 27%, diabetes …

Functional Diversity In Gii.4 Norovirus Entry: Hbga Binding And Capsid Clustering Dynamics, B Vijayalakshmi Ayyar, Carmen V Apostol, Janam Jitendra Dave, Soni Kaundal, Joseph A Kendra, Frederick H Neill, Khalil Ettayebi, Sarah Maher, Ramakrishnan Anish, Gabriel I Parra, Göran Larson, Robert L Atmar, Sue E Crawford, B V Venkataram Prasad, Mary K Estes

Faculty, Staff and Students Publications

Human noroviruses (HuNoVs), especially GII.4 strains, are the leading cause of acute viral gastroenteritis worldwide, yet no approved vaccines or antivirals exist. The pandemic GII.4 Sydney 2012 strain enters cells via membrane wounding and clathrin-independent carrier-mediated endocytosis, but it is unclear whether this entry mechanism is conserved across GII.4 variants. We compared early binding and entry of multiple GII.4 variants using wild-type and mutant GII.4 virus-like particles (VLPs) and modified human intestinal enteroid cultures. Only a subset of GII.4 variants, including GII.4 Sydney, form distinct, histo-blood group antigen (HBGA)-dependent capsid clusters on the cell surface. Clustering strains display significantly enhanced …

Phosphorylation Of Ryr1 At Ser2902 Decreases Ca2+ Leak In Skeletal Muscle And Susceptibility To Malignant Hyperthermia And Heat Stroke, Rachel Sue Zhen Yee, Chang Seok Lee, Ting Chang, Sung Yun Jung, Omar Yousif, Courtney Cavazos, John Colyer, Filip Van Petegem, George G Rodney, Susan L Hamilton

Faculty, Staff and Students Publications

The ryanodine receptor 1 (RYR1) is the sarcoplasmic reticulum (SR) Ca2+ release channel required for both skeletal muscle contraction and Ca2+ leak. Mutations in RYR1 cause malignant hyperthermia susceptibility (MHS) and enhanced sensitivity to heat stroke (ESHS), which can result in death due to excessive skeletal muscle thermogenesis upon exposure to volatile anesthetics or heat. Here, we investigated the molecular and physiological functions of phosphorylation of RYR1 at Ser2902 by the kinase SPEG (striated muscle preferentially expressed protein). Muscle from SPEG-deficient mice expressing RYR1 with a Ser2902 →Asp2902 (S2902D) point mutation to mimic phosphorylation by SPEG showed decreased SR Ca2+ …

Film Review: A Feminist Critique Of The Representation Of Women In 21st-Century Bollywood Sports Biopics, Amitabh Roy

Journal of International Women's Studies

This review critically analyses the portrayal of women in Bollywood sports biopics using a feminist perspective, with reference to three influential 21st-century films: Mary Kom (2014), Saina (2021), and Shabaash Mithu (2022). While these movies ostensibly celebrate women’s sporting achievements, a close reading discloses the durability of patriarchal currents in the narrative, visual composition, and character construction. Using feminist theories like Laura Mulvey’s “male gaze,” Judith Butler’s “gender performativity,” and bell hooks’s intersectionality, this work contends that these films simultaneously empower and limit their heroines. Exploring how femininity, family, and national pride are performed in these films, this review examines …

Revisiting “Autobiographical Reflections: My Story”: A Reflection On The Unspoken And Misconveyed, Ronak Karami

Journal of International Women's Studies

This piece revisits and reflects on my feminist essay, “Autobiographical Reflections: My Story” (2020), published in the Journal of International Women's Studies. With the benefit of years of growth and introspection, I return to that work and see more than the story I once told. I now notice the silences between the lines, the nuances I overlooked, and the unintended messages my words may have carried. This reflection is not an attempt to erase my truth but rather an effort to revisit and refine it—to provide, within the confines of a few pages, greater clarity, accountability, and context where …

Between Mothers And Daughters: Female Isolation, Despotism And Fragile Bonds In Anthony Trollope’S "Castle Richmond" And "Lady Anna", Aleksandra Tryniecka

Journal of International Women's Studies

Analyzing the dialogue in Anthony Trollope’s nineteenth-century novels Castle Richmond and Lady Anna reveals portrayals of mother-daughter conflicts that span throughout generations and carry profound societal consequences. In both novels, the mothers are depicted as ambivalent figures who simultaneously play the roles of both victim and oppressor. Relentlessly striving to redeem their past, the despotic mothers intimidate their daughters into accepting socially beneficial marriage arrangements. Using Bakhtin’s notion of dialogism, I present how in both novels, the younger generation (the daughters) adopt a fresh system of social values, which gradually results in a change in Victorian society of the second …

Antecedents And Measures Of Women’S Financial Empowerment: A Comprehensive And Global Literature Review, Priya Gupta, Mamta Aggarwal, Meera Bamba

Journal of International Women's Studies

Women’s financial empowerment has garnered greater interest in recent years, and numerous articles have highlighted gender disparities. In existing literature, antecedents and measures of economic empowerment are fragmented, with limited research that provides a comprehensive assessment framework. This systematic review aims to identify the determinants affecting women’s financial empowerment to develop a comprehensive framework to measure financial empowerment based on insights derived from an examination of 101 selected research articles published from 2001 to 2023 and exclusively sourced from the Scopus database. The search followed a comprehensive and systematic approach involving identification, selection, appraisal, and synthesis of the existing literature. …

Undoing Gender Performativities In Nawal El Saadawi’S Woman At Point Zero, Tobe Levin Von Gleichen, U. H. Ruhina Jesmin, Tasnuva Khair

Journal of International Women's Studies

Physician, psychiatrist, and Marxist activist for women’s rights, Nawal El Saadawi (1931-2021) published fiction and non-fiction exposing how a capitalistic, phallocratic social order keeps Egyptian women in thrall to men through violent suppression. Women are exploited by men, who see women as weak and prey on these presumed docile subordinates in a display of masculinity. Deciphering the effects of this gendered performativity through the lens of Judith Butler, El Saadawi’s novel Woman at Point Zero (1977/2015a), or Ferdaous, une Voix en Enfer (El Saadawi, 1977/2007) in French, provides a narrative whose significance is amplified by Butlerian theory. The protagonist, …

The Impact Of Artificial Intelligence Using The Reading Progress Tool In Microsoft Teams On English Reading Skill T For 10th Grade, Mai Hassan, Zubaida Yusuf Al-Qarza’I, Amjaad Tariq Mujallid

University of Bisha Journal for Educational Sciences

The study aimed to find the impact of Artificial Intelligence using the Reading Progress tool in Microsoft Teams on developing English reading skills for 10th grade students at one of the schools in Jeddah. The quasi-experimental approach was used on one experimental group consisted of (39) female students in 10th grade. Accordingly, data were collected by using Likert-type scale in both pre- and post-test. The results showed that there were statistically significant differences between the mean scores of the study group in the pre and posttest in favor of the post one. The results also indicated that there is a …

The Reality Of Employing Artificial Intelligence Applications By Mathematics Teachers In The Educational Process In Medinah, Salwa Salem Hamzah Barzanji

University of Bisha Journal for Educational Sciences

The study aimed to reveal the reality of mathematics teachers’ use of artificial intelligence applications in the educational process. To achieve this, the researcher designed a questionnaire consisting of (26) statements; Distributed into three main axes, the study was applied to (315) mathematics teachers in the general education stages. The results revealed that the degree of mathematics teachers’ knowledge of the importance of employing artificial intelligence applications in the educational process; was high, while the degree of mathematics teachers’ use of artificial intelligence applications in the educational process was low, and the challenges facing mathematics teachers in employing artificial intelligence …

Animation Film Industry Of India And Service Design: A Systematic Review Of Literature, Abhishek Kumar, Dr. Shikha Rai, Dr. Sonali Srivastav

ServDes Conference Series

The medium of animation transcends the physical limitations posed by other visual media, combining elements of fantasy with realism. By 2030, the animation business in India is expected to grow from ₹215.8 billion to ₹1.21 trillion. The major companies that dominate this segment in India are Disney and Pixar. The fact that the top 10 highest-grossing animation films in India are all produced by international companies, with ‘Kung Fu Panda 4(2024)’ at the top further demonstrating this foreign domination. Compared to its global counterparts, the Indian animation industry is yet to see the boom, despite the market accepting the medium. …

Empowering Rural Women Of Olasahi: Service Blueprint For A Community-Driven Sustainable Revenue Model, Gatikrushna Mohapatra, Seema Krishnakumar

ServDes Conference Series

This research paper explores the development of a sustainable business model for rural women in Olasahi, Jajpur, Odisha. Women in this region primarily engage in traditional snack-making but lack access to structured markets, have limited sources of revenue, and have limited financial awareness. The study integrates service design principles with entrepreneurship models to create a sustainable revenue framework enabling financial independence. A mixed-methods approach was employed, including surveys, focus group discussions, and case study analyses. The study highlights key barriers such as limited financial literacy, market inaccessibility, and a lack of structured business knowledge. It also identifies scalable solutions inspired …

Resilient By Design: The Dissolution Of Alternative Food Networks, Cagri G. Varli, Stefano Maffei

ServDes Conference Series

Alternative food networks (AFNs) are often presented through peak-period success stories, leaving their entire lifecycle — transformations, challenges, and reconfigurations — underexplored. By rethinking AFN dissolution process through a service design lens, this study examines how embedded values, networks, and operational models evolve beyond their initial structures. The research uses a new generation consumer cooperative as a case study, and it employs multiple sources of evidence — semi-structured interviews, archival data, media sources, and direct observations — to analyze the cooperative’s evolution. Findings reveal how AFNs transition from grassroots initiatives to structured models but struggle with economic constraints and governance …

Design Tensions Between Attractiveness And Inclusivity In Milan Public Universities: The Case Of A Student Housing Orientation Service, Nicole Sacchetti, Daniela Sangiorgi

ServDes Conference Series

As Milan public universities compete globally to attract economic capital and student flows, they simultaneously face growing challenges in addressing the housing affordability crisis affecting their student populations. This paper reflects on the design tensions emerging within the service ecosystem of Politecnico di Milano, starting from the shortcomings encountered during the development of the multidisciplinary research-action project StudMIHome: Students Living in Milan; a study on student housing conducted by three research departments of the university, with the objective of prototyping and testing a housing orientation service for students.

Generative Ai In Service Design: An Explorative Diary Study In Discovery Process, Yaoqi Li, Hyunyim Park

ServDes Conference Series

As AI technologies advance, service design practitioners should consider their role in the field, including how to integrate generative AI (GenAI) into their workflows. This study explored how service design practitioners engage with GenAI tools in the discovery phase; it was intended to enhance service design research with regard to GenAI and highlight its potential and future applications. Through a diary study, 26 service design practitioners participated in three design activities using a variety of GenAI tools and recorded their experiences and perceptions in diaries. The findings indicate that participants perceived the GenAI tools as effective for data collection, processing, …

Reframing Evaluation And “Frameworks”: Reflecting, Learning And Adapting Practices Of Social Change, Sarah Kushinsky, Yoko Akama, Ko-Le Chen, Hirotake Imanishi, Yuko Kikuchi, Sarah Teasley, Khemmiga Teerapong, Joyce Yee

ServDes Conference Series

Evaluation is a double-edged sword. For those invested in social change, it is vital to evaluate the process and impact of designing. However, traditional positivist approaches can risk harm by magnifying power through the instruments and mechanisms of evaluation, especially when Global North models are unthinkingly applied in the Global South. What is deemed valuable to know – without asking what matters to whom, how, where and when – is an ethical and political concern as it ignores how people are variously situated. This paper argues for building evaluative capacities otherwise. It shares key insights by tracing how an evaluative …

Adopting A Diffractive Approach To Journey Mapping In The Exploration Of Scaling Citizen Assemblies In Sweden, Christina M.K. Lindeberg, Nicola Morelli, Luca Simeone

ServDes Conference Series

Scaling citizen assemblies to increase their impact on sustainable transitions requires situated knowledges. Whilst service design methods can support local governments in working with situated knowledges, there has been a call for more reflection on their application. In contrast to reflection, the feminist metaphor of diffraction enables greater relationality, complexity, and impact within research; yet it remains a novel approach. This paper presents an experiment with participants of a city-level citizen assembly in Sweden. During the experiment, journey mapping was used within a diffraction apparatus, and diffractive reading enabled the collective exploration of barriers to and opportunities for scaling citizen …

Dispute Resolution As A Service: Leveraging Service Design And Ai Assistance, Ravi Mahamuni, Sachin Pawar, Manoj Apte, Girish Palshikar

ServDes Conference Series

India’s insurance dispute resolution system is burdened by long delays, escalating costs, and growing complaint volumes. With the insurance market projected to reach US$ 222 billion by 2026 and recent data showing that leading public insurers registered over 81,000 complaints in FY2023, traditional processes are no longer viable. This paper proposes a “Dispute Resolution as a Service” model for the insurance claim domain, enabled by AI technologies with service design principles. By rethinking dispute resolution as a service, the solution addresses not only the technical requirements for speed and cost reduction but also the softer aspects such as transparency, user-centeredness, …

Co-Designing Ev Dashboards For Rural India: A Participatory Approach, Parinita Rai, Prasad Onkar

ServDes Conference Series

The adoption of electric vehicles (EVs) in rural India is hindered by literacy barriers, language diversity, and infrastructural constraints. This study focuses on designing an optimized digital Human-Machine Interface (HMI) dashboard for two-wheeler EVs to enhance usability among rural consumers. Building on insights from prior research presented at Design 2024, a user-centric approach was employed, incorporating qualitative interviews to gather authentic user feedback. Key findings emphasize the need for simplified interfaces, localized content, and adaptive displays to accommodate diverse user needs. The proposed HMI design aims to reduce the learning curve and encourage EV adoption by making digital dashboards more …

Activating Community Through Transmedia Storytelling: A Service Design Case Study Of The Life As Theater Project, Shuxiao Zhong, Wanqiang Li, Fei Hu, Haihao Xu

ServDes Conference Series

In the context of declining sustainability in traditional placemaking practices, this study explores how transmedia storytelling, when integrated with service design logic, can function as a replicable and adaptive mechanism for community activation. Grounded in a media–platform–role framework, this research takes Alipay’s Life as Theater project as a case study to examine how narrative-driven tasks, distributed media touchpoints, and platform-mediated coordination work together to mobilize user participation. Through service design analysis, it identifies how digital platforms serve as both structural orchestrators and narrative translators, aligning user behaviors, merchant interactions, and platform logic into a coherent activation pathway. This study contributes …

An Overview Of The European Eel Anguilla Anguilla Fisheries In Egypt, Azza A. El Ganainy, Mohamed S. Ahmed, Mohamed F. Osman, Amany A. Mahmoud

Blue Economy

The main objective of this study is to give for the first time an overview of the geographic, seasonal and intraspecific variations in European eel (Anguilla Anguilla) stock in the Egyptian different habitats. The geographical distribution, general status as well as stocks temporal variation in Egypt are analyzed examining long term catch data sets. European eels are found in the Nile Delta and along the Mediterranean coast, occupying the brackish northern lagoons (Edko, Burullus, Manzala) and the hyper saline Bardawil lagoon. Annual total eel landings from 2013 to 2022 fluctuated, with a maximum of 1268 tons recorded in Burullus Lagoon …

Nevada's Healthcare And Education Workforce Pipelines, David Damore, Caitlin J. Saladino, William E. Brown Jr.

Policy Briefs and Reports

With ongoing workforce shortages in K-12 education, healthcare, and mental and behavioral health—occupations central to the HEAL (health, education, administration, and literacy) economy—this brief utilizes the Nevada P-20 to Workforce Research Data System (NPWR) and data from the U.S. Bureau of Labor Statistics to explore the current and projected landscape for these workforces in Nevada. Examining the demographic characteristics of those participating in focused career and technical education training and those earning relevant postsecondary credentials illuminates gender disparities in Nevada’s healthcare and education workforce pipelines. After reviewing the current state of these workforces and assessing the available NPWR data, we …

Faculty Senate Agenda October 6, 2025, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• 3:00 Call to Order
• Approval of Minutes - September 8, 2025
• 3:05 University Business
• 3:20 Faculty Senate Business
• 3:35 Information
• EPC Report - September 4, 2025
• 3:45 Report
• EPC Annual Report
• 4:10 Old Business
• 4:15 New Business
• Adjourn: 4:30 pm

Cost Of Living For Older Adults (65+) In Mountain West Metropolitan Statistical Areas, 2024, Anirudh Polagani, Annie Vong, Mohit Pande, Olivia K. Cheche, Caitlin J. Saladino, William E. Brown Jr.

Demography

This fact sheet explores 2024 cost of living data for adults over the age of 65 in the largest metropolitan statistical areas (MSAs) across five Mountain West states: Arizona, Colorado, Nevada, New Mexico, and Utah. The data are sourced from the “Elder Index,” a dashboard that focuses on housing, healthcare, food, transportation, and miscellaneous expenses that collectively reflect the monthly expenses for those over the age of 65. This fact sheet focuses on five MSAs in the Mountain West: Phoenix-Mesa-Chandler, AZ; Denver-Aurora-Centennial, CO; Las Vegas-Henderson- North Las Vegas, NV; Albuquerque, NM; and Salt Lake City-Murray, UT.

Faculty Senate Minutes October 6, 2025, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• Call to Order
• Approval of Minutes - September 8, 2025
• University Business
• Faculty Senate Business
• Information
• EPC Report - September 4, 2025
• Report
• EPC Annual Report
• Old Business
• New Business
• Adjourn - 4:30 pm

Urban Heat Islands In Mountain West Cities, 2024, Mia Tschan, Krish Sharma, Olivia K. Cheche, William E. Brown Jr.

Environment

This fact sheet presents data on Urban Heat Islands (UHIs) in six cities across five Mountain West states: Arizona, Colorado, Nevada, New Mexico, and Utah. The data are derived from the 2024 Climate Central report, “Urban Heat Hot Spots in 65 Cities,” which includes data on how UHIs boost temperatures in 65 major cities across the United States. This fact sheet focuses on UHIs in six Mountain West cities: Albuquerque, NM; Denver, CO; Las Vegas, NV; Phoenix, AZ; Salt Lake City, UT; and Tucson, AZ.

Top-Down Instruction Outweighs Emotional Salience: Nocturnal Sleep Physiology Indicates Selective Memory Consolidation, Laura B.F. Kurdziel, Carie Fiedler, Alex Gajewski, Caroline Pongratz

Psychology Faculty Publications

Introduction:

Sleep plays a crucial role in memory consolidation, not only stabilizing newly encoded information but also potentially supporting forgetting. Yet it remains unclear how sleep prioritizes what is retained or discarded when multiple salience cues, such as emotional valence and top-down instructional goals, compete for consolidation.

Methods:

In two studies, we examined how emotional content and intentional memory instruction interact to shape memory performance across a 12 h interval that included either nocturnal sleep or wakefulness. Participants completed a directed forgetting paradigm with neutral and negatively valenced words, followed by immediate recognition and delayed free recall.

Results:

In both …

Fema Public Policy Impacts On Emergency Preparedness In Florida, Sara Sambolin

Walden Dissertations and Doctoral Studies

Older adults are at an increased risk of mortality during hazardous emergencies; therefore, it is crucial to comprehend how current emergency preparedness policies are related to preparedness perceptions of older adults. Findings in recent literature identified the underrepresentation of older adults in Emergency Preparedness studies across all areas and Counties of the state of Florida as a gap that needs to be addressed. The purpose of this quantitative correlational study was to examine the relationship between the 2023 FEMA policy on emergency preparedness and the self-reported degree of preparedness among Florida’s older adult residents in urban and rural areas across …

Alloplastic Implants For Rhinoplasty: A Systematic Review And Meta-Analysis Of Clinical Outcomes And Complications, Rafeni Bunga Cikita, Beta Subakti Nataadmaja

Folia Medica Indonesiana

Alloplastic implants emphasize the importance of a comprehensive understanding of both clinical and histological aspects, which are attributed to enhancing patient satisfaction and surgical success rates. The study aims to assess the viability of different implant materials and their related risks over time. A systematic literature search was conducted across multiple databases, including PubMed, Cochrane, and EBSCOhost, to identify 79 records. After eliminating duplicates and applying specific inclusion and exclusion criteria, four new studies were included for evaluation, focusing on postoperative outcomes related to alloplastic implants in rhinoplasty. Late-onset inflammation in non-healthy capsules required removal and showed histological damage. One …