Digital Commons Network^™

Treatment Of Biopsy-Proven Laryngeal Squamous Cell Carcinoma In Situ, Praneet C. Kaki, Aman M. Patel, Lily Huang, Gavin Turner, Afash Haleem, Jason A. Brant, Robert M. Brody, Ryan M. Carey

SKMC Student Presentations and Publications

OBJECTIVE: To investigate the impact of clinical surveillance, primary radiotherapy, and primary surgery on overall survival (OS) in laryngeal carcinoma in situ (Cis).

METHODS: The 2006-2020 National Cancer Database was queried for adults with a biopsy-proven diagnosis of laryngeal Cis. Multivariable binary logistic and Cox proportional hazards regression models were implemented.

RESULTS: Of 3567 unique patients satisfying inclusion criteria, 514 (14.4%) underwent clinical surveillance, 1074 (30.1%) underwent primary radiotherapy, and 1979 (55.5%) underwent primary surgery. Receiving treatment at an academic/research facility was associated with higher odds of undergoing primary surgery compared to primary radiotherapy. Among 646 patients undergoing primary surgery …

Methemoglobinemia-Induced Cardiac Dysfunction In A Pediatric Patient, Brian Drury, Chelsea Boyd, Kelsey Van Housen, Siraj Amanullah

Student Papers, Posters & Projects

Methemoglobinemia is a rare congenital or acquired cause of functional anemia resulting from oxidation of hemoglobin. Prompt recognition and treatment are critical to prevent tissue hypoxia and end-organ injury. While other complications are well described, cardiac dysfunction is rarely reported—especially in children. We present what, to our knowledge, is the first known case of methemoglobinemia-induced transient cardiac dysfunction—or “myocardial stunning— in a pediatric patient. This case underscores the importance of maintaining a high index of suspicion and assessing cardiac involvement in such patients. Early intervention can lead to full recovery and prevent long-term sequelae, even in the presence of multiorgan …

Post-Traumatic Stress Disorder (Ptsd) In Zoulfa Katouh’S As Long As The Lemon Trees Grow, Mai Hazem El Gebali

English Language and Literature

This paper aims to analyze the representation of Post-traumatic Stress Disorder (PTSD) in Zoulfa Katouh’s novel, As Long as the Lemon Trees Grow (2022). Katouh, a Canadian-Syrian author who specializes in drug sciences, sets her debut novel against the backdrop of the war in Syria in the aftermath of the Arab Spring. The protagonist, Salama, a teenage girl pursuing an undergraduate degree in pharmacy, faces the harrowing realities of war and volunteers as a surgical assistant amidst the chaos of bombings and sniper attacks. As a result of the war, Salama tragically loses almost all her family members, and in …

Approved Courses 10-7-25, Angela Brock

Individual Course Committee (ICC)

No abstract provided.

Approved Programs 10-7-25, Angela Brock

Programs Committee (PC)

No abstract provided.

Community-Based Food Program Limits In Reducing Older Adult Food Insecurity, Madonna Harrington Meyer, Colleen M. Heflin

Population Health Research Brief Series

Older adults who are grappling with food insecurity may enhance their food supply through community-based programs that provide free and subsidized food. This complicated system, categorized by group meal programs, home-delivered meals, and food provided to be eaten off-site, is complex, expensive, and may be difficult for older adults to use. Based on the book, Food for Thought: Understanding Older Adults Food Insecurity, this brief describes three key limits of community-based food programs for older adults. First, the quantity and quality of community-based food programs vary markedly by where one lives. Second, the food may be of poor nutritional …

Compensation Committee Minutes, Clemson University Board Of Trustees, 2025 October 7, Clemson University Board Of Trustees

Minutes

No abstract provided.

Everyday Norms Have Become More Permissive Over Time And Vary Across Cultures, Kimmo Eriksson, Pontus Strimling, Irina Vartanova, Brent Simpson, Minna Persson, Khalid Ahmed Abdi, Neta Ad, Alisher Aldashev, Habib Mohammad Ali, Maurizio Alì, Khatai Aliyev, Yasser M. Alrefaee, Alberth Estuardo Alvarado Ortiz, Per A. Andersson, Giulia Andrighetto, Gizem Arikan, John Jamir Aruta, Christian Lutete Ayikwa, Jonatan Baños-Chaparro, Davide Barrera, Justina Barsyte, Birzhan Batkeyev, Azma Batool, Elizaveta Berezina, Stéphanie Ngandu Bimina, Marie Björnstjerna, Sheyla Blumen

Faculty Publications

Every social situation that people encounter in their daily lives comes with a set of unwritten rules about what behavior is considered appropriate or inappropriate. These everyday norms can vary across societies: some societies may have more permissive norms in general or for certain behaviors, or for certain behaviors in specific situations. In a preregistered survey of 25,422 participants across 90 societies, we map societal differences in 150 everyday norms and show that they can be explained by how societies prioritize individualizing moral foundations such as care and liberty versus binding moral foundations such as purity. Specifically, societies with more …

The Use Of Long-Acting Injectables For People With Schizophrenia: Consensus Panel Recommendations For Overcoming Barriers And Implementing Treatment, Martha Sajatovic

Faculty Scholarship

Introduction: Antipsychotic medications are effective for people living with schizophrenia, but long-term treatment adherence remains challenging, leading to relapses and poor outcomes. Long-acting injectable antipsychotics (LAIs) may improve adherence and reduce relapses compared with oral antipsychotics. Barriers to the use of LAIs exist, yet practical recommendations to overcome them are lacking. Therefore, an expert consensus panel was formed to develop key recommendations using a modified Delphi panel method. Methods: The panel chair and Interactive Forums, Inc., conducted a narrative literature review of English-language articles published in the 10 years before 02/02/2024. Panelists rated, discussed, and re-rated proposed statements during 2 …

Icc Agenda 10-7-25, Angela Brock

Individual Course Committee (ICC)

No abstract provided.

Ucc Minutes 10-7-25, Angela Brock

UCC Agendas/Minutes

No abstract provided.

The Prospector, October 7, 2025, Utep Student Publications

The Prospector

No abstract provided.

Implementation Mapping To Identify Best Practices For Implementing Population-Wide Genomic Screening Programs: Protocol For The Focus (Facilitating The Implementation Of Population-Wide Genomic Screening) Study, Megan Roberts, Jarrod Marable, Kimberly Foss, Cason Whitcomb, Deborah Cragun, Adam Buchanan, Miranda Hallquist, Nathaniel Baker, Rebecca Bosch, Derek W Craig, Ingrid Wagner, Maria Fernandez, Chanita Hughes-Halbert, Caitlin Allen

Faculty, Staff and Student Publications

Background: Population-wide genomic screening (PGS) for genetic conditions such as hereditary breast and ovarian cancer syndrome, Lynch syndrome, and familial hypercholesterolemia presents opportunities to reduce morbidity and mortality among the 1%-2% of the population at elevated risk for these serious, preventable diseases. With decreasing sequencing costs and growing support from national bodies, there are increasing numbers of PGS programs in the United States. However, guidelines and strategies to support implementation are limited, especially regarding equitable access to PGS. Contextual factors, such as organizational structures and processes, impact PGS implementation, often failing to benefit underrepresented populations. To address these challenges, we …

The Trial Of Musammat Kelee: Widowhood, Infanticide, And Colonial Justice In Early Twentieth Century India, Rashmi Banerjee

Socio-Legal Review

This article examines the 1920 trial of Musammat Kelee, a Hindu widow from Ajmer-Merwara, accused of drowning her illegitimate infant son in a lake. Drawing on extensive trial records, police reports, and official correspondence, it reconstructs the procedural history of her case and situates it within broader colonial debates on female sexuality, widowhood, and infanticide. Kelee’s conviction under Section 302 of the Indian Penal Code, despite weak evidence, hinged on judicial emphasis on her widowhood and the perceived illegitimacy of her child as proof of motive. Yet her subsequent pardon by the Viceroy’s office reflected a contradictory administrative impulse that …

A Novel Turmeric Drying Approach Based On Supercritical Carbon Dioxide, Sumanjot Kaur, Arda Tuhanioglu, Ali Ubeyitogullari

Food Science Faculty Publications and Presentations

As a widely used spice, turmeric is rich in curcuminoids, which are known for their anti-inflammatory and antioxidant properties. However, the drying process, especially at high temperatures, often leads to significant curcumin degradation, impacting its bioactivity and quality. This study investigates drying turmeric using an innovative approach based on supercritical carbon dioxide (SC-CO2), and conventional drying methods (oven drying and freeze-drying) in terms of curcuminoid retention, color, solubility, chemical interactions, crystallinity, and morphology. The results revealed that SC-CO2 drying preserved up to 82.3 mu g curcuminoids /mg dried turmeric, which was significantly higher than the levels retained by oven drying …

A Soft-Stiff Patterned Bioengineering Model Reveals Kinase Pathways Driving Directional Cell Migration In Pulmonary Arterial Hypertension, Tamanna Islam, Jacob Hooper, Xiaojun Zhang, Clarissa Garcia, Md Mahedi Hasan, David H Drewry, Mohammad Anwar Hossain, Taslim A Al-Hilal

Faculty, Staff and Student Publications

Directional cell migration by pulmonary arterial cells (PACs) is one of the important features of diseases involving arterial remodeling, such as pulmonary arterial hypertension (PAH), a disease that is often characterized by reduced arterial compliance and increased extracellular matrix (ECM) stiffening. However, there are no therapeutics that can halt the directional cell migration of PACs in PAH. The inability to identify drug targets or drugs against the directional cell migration during PAH pathogenesis stems from an incomplete understanding of the process and a lack of effective translational models for screening of candidate small molecules. Here, for the first time, we …

Advances In Fret Methodologies For Probing Molecular Interactions, Geetika Verma, Vasanthi Jayaraman

Faculty, Staff and Student Publications

Förster resonance energy transfer (FRET) has evolved into a powerful, quantitative approach for probing biomolecular structure, dynamics, and interactions. This research highlight brings together recent studies in Biophysical Journal that push the boundaries of traditional FRET. These innovations expand the spatial and temporal resolution of FRET, enabling its application to increasingly complex biological systems.

Representation Is Power: Traditional, Hybrid, And Digital Recruitment Results From A Non-Randomized Clinical Trial Engaging Adolescents, Taylor B Harrison, Jessica A Sinclair, Lisa J Martin, Kristin Childers-Buschle, Holly Elder, Sunyang Fu, Hongfang Liu, William B Brinkman, Melanie F Myers, Michelle L Mcgowan

Faculty, Staff and Student Publications

Clinical trials support the iterative advancement of modern medicine. However, challenges in achieving population-representativeness or participant sampling commensurate with the burden of disease can limit the generalizability and reproducibility of trial results. Here, we present the recruitment strategies and cohort profile of the Engaging Adolescents in Decisions about Return of Genomic Research Results non-randomized clinical trial (NCT0448106), where traditional, targeted hybrid, and digital recruitment methods were implemented with quota sampling to enroll diverse adolescents (ages 13-17) and young adults (ages 18-21). The largest proportion of participants enrolled through digital strategies (39.1%), followed by traditional (34.2%), and targeted hybrid strategies (23.2%). …

From Fort To Prison: The Production Of Iloilo City, Ram Paulo A. Anayan

Akda: The Asian Journal of Literature, Culture, Performance

The foundation of colonial cities in the Philippines rests on violence. The Spanish policies of the reducción forced the natives to settle in pueblos where colonial power is ensured. The resistance of some natives brought about the divide between tagabayan (town dweller) and tagabundok (mountain dweller)—respective connotations of civilization and savagery (Lumbera and Lumbera, 36). This paper examines how this centripetal-centrifugal force of simultaneous identity-production and displacement is echoed in the metonymy of the fort on which the origins of Iloilo City stand. I navigate how this movement manifests in the consciousness of the city across historical periods represented by …

Contributors

Akda: The Asian Journal of Literature, Culture, Performance

No abstract provided.

Does The Acquisition Of Spanish Affect The Acquisition Of English? A Longitudinal Study Of Minority-Majority Simultaneous Bilingual Development From 2.5 To 12 Years, Heather J. Johnson

Electronic Theses and Dissertations 2020 - Present

Past work with bilinguals suggests that the acquisition of one language has an impact on the acquisition of another. What is unclear is the direction and strength of the relation between the two languages and whether the relation changes with age. Participants were children in South Florida who heard both Spanish and English at home. They were assessed in expressive (from 2.5 to 12 years) and receptive vocabulary (from 4 to 12 years). Both concurrent bivariate correlations and bivariate splines were used to evaluate the cross-language relations. Results suggest that early in acquisition the two languages compete for resources, but …

Genetics-Nutrition Interactions Control Diurnal Enhancer-Promoter Dynamics And Liver Lipid Metabolism, Dishu Zhou, Ying Chen, Panpan Liu, Kun Zhu, Juliet Holder-Haynes, S Julie-Ann Lloyd, Cam Mong La, Inna I Astapova, Seunghee Choa, Ying Xiong, Hosung Bae, Marlene Aguilar, Hongyuan Yang, Yu A An, Zheng Sun, Mark A Herman, Xia Gao, Liming Pei, Cholsoon Jang, Joshua D Rabinowitz, Samer G Mattar, Yongyou Zhang, Dongyin Guan

Faculty, Staff and Student Publications

The circadian clock controls 24-h rhythmic processes. However, how genetic variations outside clock genes impact peripheral diurnal rhythms remains largely unknown. Here, we find that genetic variation contributes to different diurnal patterns of hepatic gene expression in both humans and mice. Nutritional challenges alter the rhythmicity of gene expression in mouse liver in a strain-specific manner. Remarkably, genetics and nutrition interdependently control more than 80% of rhythmic gene and enhancer-promoter interactions (E-PIs), with a noncanonical clock regulator, estrogen-related receptor gamma (ESRRγ), emerging as a top transcription factor during motif mining. Knockout of Esrrγ abolishes strain-specific metabolic processes in response to …

Social Media, Social Sensibilities, And The Employment Relationship, Matthew W. Finkin

The Journal of Contemporary Legal Issues

Employers have long made decisions based on the applicant’s or incumbent employee’s respectability. Those whose transgress the bounds could be excluded; e.g., those who publicly embrace the Ku Klux Klan.[] In other words, frank speech—speech “unconstrained by anything that might normally encourage one to be more circumspect,”[] speech revealing one’s “true feelings, however repellant to popular morality”[]—is not invariably a good thing.[]

When social media came into wide use, employers extended their monitoring of applicants and incumbents for the acceptability of that speech.[] There is nothing new in that.[] In the absence of a clear direction embodied in law …

Comment On Hurd And Moore, Richard Arneson

The Journal of Contemporary Legal Issues

In their essay on “Wrongful Student Speech and Rightful Private University Responses to It,” Professors Heidi Hurd and Michael Moore (hereafter, Hurd & Moore) deepen the discussion by situating it in a general account of moral limits on freedom of expression and by noting connections to some of their own views on moral theory. The result is an excellent primer on freedom of speech, and more than just a primer. Their general views are shown to have plausible implications for tangled questions about what private university administrators ought to do in response to problematic examples of campus protest. That this …

From Mill To Mussolini And On To Microsoft: Freedom Of Speech In A Neo-Corporatist Era, Maimon Schwarzschild

The Journal of Contemporary Legal Issues

John Stuart Mill’s On Liberty—a fundamental text for political liberalism—not only defended the importance of freedom of expression and debate, but suggested that social pressure from private persons and institutions can be as much, or more, of a threat to freedom, including freedom of expression, as any legal sanction or act of government. Mill feared “a social tyranny more formidable than many kinds of political oppression” which “leaves fewer means of escape, penetrating much more deeply into the details of life, and enslaving the soul to itself”.

Recent decades in America have seen efforts to suppress free expression by colleges …

Interpreting The Law And Complying With It, Larry Alexander

The Journal of Contemporary Legal Issues

In this Article, I am going to focus on a set of issues that follow from the fact that laws are created by human beings and interpreted by human beings. It is unlike morality in these respects. For morality presumably applies to us humans, whether we accept what it requires or correctly assess what it requires. But it is we who decide what laws, good or bad, should govern us, and whose interpretations of those laws, correct or incorrect, should constitute our governing laws. And if the uncertainty of what morality requires creates the necessity for laws, and if laws, …

Multicenter Stroke Preclinical Assessment Network Analysis Of Cardiovascular Risk Factor Subgroups Treated With The Poly(Adp-Ribose) Polymerase Inhibitor Veliparib, Raymond C Koehler, Karni Bedirian, Mu-Hsun Chen, Yanrong Shi, Suyi Cao, Brooklyn D Avery, Senthilkumar S Karuppagounder, Kazi Akhter, Adnan Bibic, Valina L Dawson, Ted M Dawson, Márcio A Diniz, Jessica Lamb, Karisma A Nagarkatti, Anjali Chauhan, Jaroslaw Aronowski, Louise D Mccullough, Andreia Lopes De Morais, Xuyan Jin, Cenk Ayata, Mariia Kumskova, Rakesh B Patel, Anil K Chauhan, Enrique C Leira, Pradip K Kamat, Mohammad B Khan, Krishnan M Dhandapani, David C Hess, Ligia S B Boisserand, Basavaraju G Sanganahalli, Lauren H Sansing, Patrick D Lyden

Faculty, Staff and Student Publications

Background: The Stroke Preclinical Assessment Network tested 6 therapeutic interventions initiated at the time of reperfusion after focal ischemic stroke in young mice, aging mice, obese mice, and spontaneously hypertensive rats. This randomized, controlled trial was conducted across 6 sites with concealed treatment and blinded neurobehavior assessments. The trial had an adaptive design with preset levels of efficacy and futility interrogated after each of 4 stages. The primary outcome was turning preference on the corner test at 1 month. The PARP (poly(ADP-ribose) polymerase) inhibitor, veliparib, was considered futile after the second stage when pooling all animal models (n=231 …

Factors Associated With Corrective Actions, Remediation, And Employment Termination Of Emergency Physicians, Lyndsay Tyler, Yachana Bhakta, Michael Gottlieb, Chadd K. Kraus, Terry Kowalenko, Yvette Calderon, Samuel M. Keim, Diane L. Gorgas, Deborah B. Diercks, Lewis S. Nelson

Department of Emergency Medicine Faculty Papers

OBJECTIVE: Medical professionalism is fundamental to the delivery of high-quality patient care. There is a paucity of data to describe behaviors associated with negative professional and employment outcomes. This study examines common factors leading to corrective actions, remediation, and termination of emergency physicians (EPs).

METHODS: This was a cross-sectional survey sent to academic chairs in emergency medicine to identify factors for corrective actions, remediation, or termination of EPs. Survey items were piloted and response process validity gathered prior to administration. Data are reported as descriptive statistics.

RESULTS: 60 of 167 (36 %) members of the Association of Academic Chairs in …

Biliverdin Reductase A Is A Major Determinant Of Protective Nrf2 Signaling, Chirag Vasavda, Ruchita Kothari, Navneet Ammal Kaidery, Suwarna Chakraborty, Sunil Jamuna Tripathi, Ryan S Dhindsa, Cristina Ricco, Shruthi Shanmukha, Samaneh Saberi, Julia E Lefler, Priyanka Kothari, Kalyani Chaubey, Adele M Snowman, Michael C Ostrowski, Eugenio Barone, Lakshminarayan M Iyer, L Aravind, Sudarshana M Sharma, Andrew A Pieper, Bobby Thomas, Solomon H Snyder, Bindu D Paul

Duncan NRI Faculty and Staff Publications

Biliverdin reductase A (BVRA), the terminal enzyme in heme catabolism, generates the neuroprotective and lipophilic antioxidant bilirubin. Here, we identify a nonenzymatic role for BVRA in redox regulation. Through phylogenetic, genetic, biochemical, and enzymatic assays, we found that BVRA exerts critical nonenzymatic antioxidant activity. Transcriptomic analyses further revealed that BVRA physically and genetically interacts with nuclear factor erythroid-derived factor-like 2 (NRF2), a major transcriptional regulator of cellular redox signaling. ChIP-seq and RNA-seq analyses reveal that BVRA and NRF2 coordinate the expression of antioxidant genes, many of which are typically dysregulated in neurodegenerative conditions such as Alzheimer's disease. Thus, this noncanonical …

The Latest In Resuscitation Research: Highlights From The 2024 American Heart Association's Resuscitation Science Symposium, Gabriela M Galli, Aarthi Kaviyarasu, Sachin Agarwal, Catherine R Counts, Tommaso Scquizzato, Betty Yang, Clark G Owyang, Ryan Coute, Simon Orlob, Lindsay Shepard, Saleem Halablab, James Horowitz, Sarah Perman, Ryan Morgan, Anne Grossestreuer, Jacob Vine, Nicholas Johnson, Luke Andrea, Ari Moskowitz, Benjamin Abella, Cameron Dezfulian, Walid H Farooqi, Felipe Teran

Faculty, Staff and Students Publications

No abstract provided.