Digital Commons Network^™

A Knowledge-Driven Deep Learning Framework For Organoid Morphological Segmentation And Characterization, Yiming Qin, Jiajia Li, Yin Heng, Zheyuan Wang, Dezhi Wu, Mahi Rahman, Pengwei Hu, Tobias Plötz, Alexander Hopp, Nicholas Kurniawan, Mathias Winkel, Philipp Harbach, Chunling Tang, Feng Tan

Publications

BACKGROUND: Organoids have great potential to revolutionize various aspects of biomedical research and healthcare. Researchers typically use the fluorescence-based approach to analyse their dynamics, which requires specialized equipment and may interfere with their growth. Therefore, it is an open challenge to develop a general framework to analyse organoid dynamics under non-invasive and low-resource settings.

RESULTS: In this paper, we present a knowledge-driven deep learning system named TransOrga-plus to automatically analyse organoid dynamics in a non-invasive manner. Given a bright-field microscopic image, TransOrga-plus detects organoids through a multi-modal transformer-based segmentation module. To provide customized and robust organoid analysis, a biological knowledge-driven …

Improving Suicide Risk Detection And Management In Primary Care, Syndie Volcy

Walden Dissertations and Doctoral Studies

Suicide remains a critical public health issue in the United States, with rates continuing to rise despite national prevention initiatives. Primary care settings serve as a pivotal point for early detection, yet inconsistent use of standardized screening and safety planning tools contributes to under-recognition of suicide risk. This Doctor of Nursing Practice (DNP) project aimed to enhance the identification and management of suicide risk in primary care by developing and implementing an evidence-based clinical practice guideline (CPG). The project addressed the practice-focused question: Does implementing a standardized suicide prevention guideline using validated tools improve risk detection and management in primary …

Elementary Teachers' Challenges To Implement Letrs In A Local Alabama School District, Jessica Morton

Walden Dissertations and Doctoral Studies

While the Language Essentials for Teachers of Reading and Spelling (LETRS) professional development provided elementary teachers with a new form of instruction, third-grade reading scores remain below proficiency levels on the Alabama state test. Guided by Vygotsky’s theory of social constructivism, the purpose of this basic qualitative study was to explore elementary teachers’ challenges of implementing LETRS in a local Alabama school district. Two research questions addressed the challenges of and suggestions for implementing LETRS. Data were collected through semistructured interviews with 10 elementary teachers in local school districts who were trained in LETRS, implemented LETRS in classroom instruction, and …

Relationship Of Job Demands And Perceived Usefulness Of Virtual Nursing Technology Among Bedside Nurses In Acute Care Settings, Oluponle Olubajo

Walden Dissertations and Doctoral Studies

Bedside nurses in acute care settings face intensified job demands amid persistent low nursing staff census and rising patient acuity. The purpose of the study, guided by the job demands–resources (JD-R) model, was to examine the relationship between job demands, years of nursing experience, and perceived usefulness of virtual nursing technology among bedside nurses in acute care settings. A cross-sectional online survey was administered to bedside registered nurses (N = 102) currently using virtual nursing technology. Measures included the Intensification of Job Demands Scale and the Perceived Usefulness Scale. Data analyses indicated that the multiple regression was not statistically significant, …

Integration Of An Artificial Intelligence–Based Autism Diagnostic Device Into The Echo Autism Primary Care Workflow: Prospective Observational Study, Kristin Sohl, Erik Linstead, Kelianne Heinz, Elia Eiroa Lledo, Alicia Brewer Curran, Melissa Mahurin, Valeria Nanclares-Nogués, Carmela Salomon, Minda Seal, Sharief Taraman

Engineering Faculty Articles and Research

Background: Pediatric specialist shortages and rapidly rising autism prevalence rates have compelled primary care clinicians to consider playing a greater role in the autism diagnostic process. The ECHO Autism: Early Diagnosis Program (EDx) prepares clinicians to screen, evaluate, differentiate, diagnose, and provide longitudinal care for children with autism in primary care settings. Canvas Dx is a prescription-only Software as a Medical Device designed to support clinical diagnosis or rule out of autism, including in primary care settings. It is authorized by the Food and Drug Administration for use, in conjunction with clinical judgment, in 18‐ to 72-month-olds with indicators …

Exploring Challenges Of Parents With Disabilities Affecting Custody Of The Children, Kendyll King

Walden Dissertations and Doctoral Studies

Despite the Americans with Disabilities Act of 1990 promoting equality for people with disabilities, parents with developmental and intellectual disabilities experience high rates of involvement with child welfare services due to outdated terminology, information about disabilities, and policies. The purpose of this study was to identify the challenges of parents with intellectual and developmental disabilities and determine if they differ from those of parents without a disability. This was a generic qualitative study grounded in intersectionality theory. Education, employment, health and safety concerns, independence, assistive technology, social services involvement, and supports or resources were examined through the perspective of the …

School Counselors Lived Experiences With Executing Child-Centered Play Therapy In High-Diversity Elementary Schools, Ruth Devito

Walden Dissertations and Doctoral Studies

Minority students are often omitted from social, economic, cultural, and political life due to ethnicity or poverty, which increases their risk of adverse childhood experiences, such as abuse or neglect, and increases their likelihood of discrimination that can obstruct their normal childhood development, including academic performance. Child-centered play therapy (CCPT) is a multiculturally appropriate approach that creates a safe and nonjudgmental environment, supporting adjustment and coping. However, many school counselors are not using CCPT. The research question was as follows: What are the lived experiences of school counselors who use CCPT in their work at high-diversity elementary schools? This study …

Occurrence Of Delphinids Off Egmont Atoll, Chagos Archipelago: Detection, Characterisation, And Temporal Variability Of Vocalisations, Udayanga Sampath, Clare B Embling, Danielle V Harris, Tom B Letessier, Isha Shyam, Simon N Ingram, M F M Fairoz, Samina Sharmin Rouf, Asha De Vos

School of Biological and Marine Sciences

Passive acoustic monitoring techniques are useful for studying vocally active marine species, particularly in remote and difficult to access areas. In this study, three months of acoustic recordings were collected off Egmont Atoll, Chagos Archipelago in the central Indian Ocean to detect, characterise, and investigate temporal variability of delphinid whistles. A subsample (3.6% of the total dataset) was used to manually annotate whistles and test automated whistle detectors. Higher frequency whistles (6-25 kHz, n = 126) were manually classified into six categories: upsweep (56%), convex (19%), downsweep (13%), concave (5%), sine (4%), and constant frequency (3%). An automated whistle detector …

A Standard-Based Taxonomy Of Features That Affect User Response To Clinical Decision Support Alerts, Siru Liu, Allison B Mccoy, Dean F Sittig, Josh F Peterson, Thomas A Lasko, Adam Wright

Faculty, Staff and Student Publications

Objective: The objective of this work is to develop a standard-based taxonomy of features that might affect user response to alerts using evidence from literature and public alert logic repositories.

Methods: We developed a taxonomy of features using multiple sources: (1) the Agency for Healthcare Research and Quality (AHRQ) CDS Connect Repository, (2) alert logic from commercial electronic health record (EHR) customers, and (3) published literature. Three categories (patient, provider, environment/context) were used a priori to develop the taxonomy. The final taxonomy was mapped to the Fast Healthcare Interoperability Resources (FHIR) standard for development of standardized CDS services.

Results: Aggregating …

Sexually Dimorphic Sail Feathers In The Mandarin Duck As A Model For Lifelong Developmental Modulation, Pin-Chi Tang, Hsu-Chen Cheng, Gee-Way Lin, Yung-Chih Lai, Ya-Chen Liang, Ping Wu, Tzu-Chiao Lin, Chen Siang Ng, Isheng Jason Tsai, Ang Li, Wen Hsiung Li, Chih-Feng Chen, Cheng-Ming Chuong, Randall Widelitz

Faculty, Staff and Student Publications

Developmental processes extend beyond embryogenesis to support lifelong tissue adaptations. Avian feather follicles, with their resident stem cells and capacity for cyclic regeneration, provide a dynamic model for postnatal tissue remodeling. Here, we propose the Mandarin duck (Aix galericulata) as an ideal model to study lifelong developmental modulation, focusing on the sexually dimorphic "sail feather"-a secondary flight feather in males that undergoes seasonal transformation into a strikingly asymmetric, ornamented phenotype during the breeding season. We identified asymmetric morphogen expression in regenerating male sail feathers and used transcriptome and H3K27ac ChIP-seq to uncover male and female signaling pathways and regulatory elements. …

Research Progress On The Effect Of Grafting Technology On Disease Resistance And Stress Resistance Of Watermelon, Xuena Liu, Shikai La, Chang Chen, Ainong Shi, Mingjiao Wang, Yingying Zhang, Jinghuai Guo, Lingdi Dong

Horticulture Faculty Publications and Presentations

Grafting is an effective horticultural technique that significantly enhances disease resistance and stress tolerance in watermelon. This review systematically summarizes the types of rootstocks used in watermelon grafting and analyzes the effects of grafting on plant responses to biotic stresses, such as viral and fungal pathogens, root-knot nematodes infections, and abiotic stresses, including drought, temperature extremes, and salinity. Furthermore, it discusses the changes in fruit quality and explores the underlying mechanisms associated with graft-induced resistance. By synthesizing recent research advances, this review aims to offer valuable insights and practical references for improving resistance and promoting sustainable production in cucurbit and …

Fort Brooke After 200 Years: A Public Heritage Approach, Alex F. Fawbush

USF Tampa Graduate Theses and Dissertations

Fort Brooke, established in 1824 at the mouth of the Hillsborough River, shaped the growth of Tampa and Florida’s west coast for nearly sixty years and served as the nucleus for the forced removal of Indigenous people. Though the Fort itself has long since vanished beneath the modern city, archaeology has preserved its legacy. Excavations since the 1970s have uncovered rich assemblages of ceramics, glass, military equipment, faunal remains, and domestic refuse. These materials reveal daily life at the post, highlighting the interactions of soldiers, Seminoles, African Americans, white settlers, and Cuban fishermen, while also uncovering the deeper prehistoric, referred …

The Orange Glow In The Sunshine State: Three Visions Of Plato In Florida (1970-1990), Ryan Mcgahan

USF Tampa Graduate Theses and Dissertations

The PLATO network, a collection of mainframe computers, terminals, and educational software, has received an increasing amount of scholarly attention in the last decade as a social precursor to the modern internet. Existing histories have neglected to investigate the ways in which PLATO and its related business enterprise worked to accelerate the shift in university governance away from classical liberal ideas centering the public good and towards a more profit-centered neoliberal rationality. By tracing the rise of PLATO in Florida universities, this paper argues that PLATO aided and was aided by the shifting priorities of American universities in the 1970s …

The Marriage Of Reason And Imagination In British Romantic Poetry, Evelina Mykhovska

Electronic Theses and Dissertations Archive

There is a general consensus among literary critics that the Romantic Era stands for a celebration of Imagination and an elevation of the latter to a status of a superior mental faculty. This generalization, however, fails to acknowledge that the project of the Romantics was not so much to extol Imagination over Reason, as to unify the two faculties. In fact, the work of major Romantic poets in Britain reveals that what the Romantics mean by “Imagination” is actually Imagination unified with Reason (that is, “Primary Imagination” unified with “Primary Reason,” the merging of which forms the “One Mind”), and …

2025-10-21 Master Of Education Arts - Secondary, Morehead State University. Faculty Senate., University Graduate Committee.

Faculty Senate Records

Proposed revisions to the Master of Arts Education for the Secondary track approved on October 21, 2025.

2025-10-21 Master Of Education Arts - Middle Grades Revision, Morehead State University. Faculty Senate., University Graduate Committee.

Faculty Senate Records

Proposed revisions to the Master of Arts Education for the Middle Grades track approved on October 21, 2025.

2025-10-21 Master Of Arts Education - Elementary Revisions, Morehead State University. Faculty Senate., University Graduate Committee.

Faculty Senate Records

Proposed revisions to the Master of Arts Education for the Elementary track approved on October 21, 2025.

Exploring The Role Of Culture And Bilingualism In Programming Activities: Lessons From African Educators, Emma R. Dodoo, Katharine Childs, Ethel Tshukudu

Faculty Research, Scholarly, and Creative Activity

The delivery of culturally relevant content in K-12 computing education is widely recognized as essential for engaging students and fostering meaningful learning experiences. However, in many African contexts, K-12 computing teachers feel unprepared to address this need. Course materials often fail to reflect the cultural and linguistic diversity of the students they serve. In this study, we conducted participatory design sessions with education stakeholders, including primary and secondary school teachers, to develop culturally relevant programming activities for a national programming outreach initiative in Botswana. Our findings emphasize the importance of relatable examples and a balanced approach to integrating cultural elements …

Contextualizing Introductory Computer Science: Insights From African Faculty, Ethel Tshukudu, Ismaila Temitayo Sanusi, Oluwakemi Ola, Sally Hamouda, Linda Marshall, Oluwatoyin Adelakun-Adeyemo, Emma R. Dodoo, G. Ayorkor Korsah, Sandani Luvhengo, Jack Parkinson

Faculty Research, Scholarly, and Creative Activity

Contextualizing computer science education has been recognized as a key factor in enhancing student engagement and learning outcomes. This study investigates the initial perceptions of university computer science faculty in Africa regarding the benefits, adoption challenges, and institutional support required for the successful integration of contextually relevant materials into introductory computer science (CS1) courses. Faculty then assessed a set of previously developed contextually tailored materials, grounded in Banks' Additive Approach to curriculum reform and aligned to the CS curricula 2023. The research adopted qualitative methods, gathering data through open-ended surveys from 22 CS faculty across 9 African countries. Thematic analysis …

Injectable Microparticle-Nanoliposome Hydrogel For Extended Release Of Small Hydrophilic Molecules, Gil Aizik, Wonmin Choi, Claire A Ostertag-Hill, Matthew Torre, Daniel S Kohane

Duncan NRI Faculty and Staff Publications

Achieving sustained local release of small hydrophilic drugs is challenging and is particularly important when the drugs are toxic. To address these challenges, we developed a hybrid system comprising drug-containing microparticles embedded within a nanoliposomal hydrogel matrix. This system forms through salt-induced gelation using physiologically relevant sodium chloride concentrations (0.9%), allowing for microparticle encapsulation without harsh chemical processes. In vitro, the hybrid system exhibited a slower release of encapsulated cargo compared to microparticles or hydrogel alone. In vivo proof of principle was provided with tetrodotoxin (TTX), a small hydrophilic and ultrapotent local anesthetic, which can cause systemic toxicity if the …

Apoa1 Binding Protein Promotes Lymphatic Cell Fate And Lymphangiogenesis By Relieving Caveolae-Mediated Inhibition Of Vegfr3 Signaling, Jun-Dae Kim, Surbhi Chaudhary, Weiqing Chen, Jonathan Astin, Philip S Crosier, Pengchun Yu, John P Cooke, Henry J Pownall, Hugo J Bellen, Nhat-Tu Le, Daniel L Kiss, Guangyu Wang, Stanley G Rockson, Hong Chen, Longhou Fang

Faculty, Staff and Students Publications

The lymphatic system maintains tissue fluid balance, and its dysfunction can result in lymphedema. Although cholesterol is essential for cellular function, its role in lymphatic development has remained unknown. Here, we identify APOA1 binding protein (AIBP) as a key regulator that promotes lymphatic endothelial cell fate specification and lymphangiogenesis. Mechanistically, AIBP reduces plasma membrane cholesterol content, thereby enhancing VEGFR3 signaling by disrupting caveolae—small plasma membrane invaginations formed by the scaffolding protein caveolin-1 (CAV-1)—and relieving CAV-1–mediated inhibition. In zebrafish and mice, AIBP loss impairs VEGFR3 signaling and lymphatic development, defects that can be rescued by CAV-1 deletion or by a VEGFR3 …

Sperm And Offspring Production In A Nonobstructive Azoospermia Mouse Model Via Testicular Mrna Delivery Using Lipid Nanoparticles, Daisuke Mashiko, Chihiro Emori, Yuki Hatanaka, Daisuke Motooka, Chen Pan, Yuki Kaneda, Martin M Matzuk, Masahito Ikawa

Faculty, Staff and Students Publications

Microsurgical testicular sperm extraction (microTESE) with intracytoplasmic sperm injection (ICSI) represents the current standard treatment for nonobstructive azoospermia (NOA). However, cures remain unavailable for NOA patients lacking retrievable haploid cells. mRNA supplementation could be a potential treatment for genetic defects leading to impaired spermatogenesis. Lipid nanoparticles (LNPs) have emerged as mRNA delivery vehicles with minimal risk of genome integration; however, their ability to selectively deliver mRNA to specific cell types remains limited. To overcome this, microRNA (miRNA) target sequences were incorporated into mRNA constructs to restrict expression specifically to germ cells. Using pyruvate dehydrogenase E1 subunit alpha 2 (PDHA2) knockout …

Everolimus And Low-Dose Tacrolimus After Heart Transplant In Children: A Randomized Clinical Trial, Christopher S Almond, Kevin P Daly, Erin L Albers, Juan C Alejos, Rebecca Ameduri, Scott R Auerbach, Lynsey Barkoff, Aliessa P Barnes, Matthew J Bock, Arene Butto, Waldemar F Carlo, Chesney D Castleberry, Maryanne R Chrisant, Shriprasad R Deshpande, William J Dreyer, Melanie D Everitt, Brian Feingold, Selena Gonzales, Seth A Hollander, Steven J Kindel, Gloria L Klein, Ashwin K Lal, Jacqueline M Lamour, Joanne Lee, Minmin Lu, Irene D Lytrivi, Shelley D Miyamoto, Elfriede Pahl, David M Peng, Thomas D Ryan, Tajinder P Singh, Jennifer A Su, David L Sutcliffe, A Marian Ybarra, Steven Zangwill, Joseph W Rossano, Lynn A Sleeper

Faculty, Staff and Students Publications

Importance: Studies suggest that everolimus may reduce the risk of rejection, cardiac allograft vasculopathy (CAV), chronic kidney disease (CKD), and cytomegalovirus (CMV) after heart transplant. Everolimus use is controversial because of data demonstrating higher infection deaths when everolimus is introduced de novo after transplant. It is unclear whether everolimus is safe and effective when initiated at 6 months posttransplant in children, a population in which median graft survival is limited to 15 years and randomized clinical trials are lacking.

Objective: To evaluate the safety and efficacy of everolimus combined with low-dose tacrolimus to prevent major adverse transplant events (MATEs) in …

Emergency Department-Initiated Palliative Care Screening Among Older Adults: A Systematic Review And Meta-Analysis Protocol, Dimitri E Lin, Satheesh Gunaga, Fabrice I Mowbray, Eric D Isaacs, Daniel Markwalter, Naomi George, Alison E Hay, Rita Manfredi, Erica Westlake, Murtaza Akhter, Jason K Bowman, Naomi Rebollo-Lee, Brian Gacioch, Alexander D Ginsburg, Justin Kenneth Brooten, Sarah Pajka, Katie Selman, Paul Bain, Joshua J Davis, Shan Liu, Kei Ouchi

Faculty, Staff and Students Publications

Introduction: The rapidly growing population of older adults (individuals aged 65 years and older) presents a new set of challenges for healthcare providers in the emergency department (ED), given the prevalence of severe and life-threatening conditions among this group, such as chronic cancer, Alzheimer's disease/dementia and congestive heart failure. ED encounters often represent a critical point in an older patient's trajectory of care and can thus be an important opportunity for various interventions such as palliative care consultation. Therefore, identifying those who will benefit most from palliative care is of high importance, especially in determining the course of future treatment. …

An Empirical Investigation Into The Effect Of Brain Drain “Japa Syndrome” On Agile Practitioners Developing Healthcare Information Systems Software In Nigeria, Yazidu Buba Salihu, Julian M. Bass, Gloria E. Iyawa

Communications of the IIMA

Within the software engineering context, agile approaches encourage customer collaboration, iterative development, and flexibility. However, the mass exodus of highly skilled professionals, known as the “brain drain” or "Japa Syndrome," has emerged as a significant challenge, especially in Nigeria. This phenomenon has particularly impacted agile software development practitioners by undermining project continuity, knowledge transfer, and team dynamics. This study empirically examines the effect of brain drain, “Japa Syndrome,” on agile practitioners developing healthcare information systems software in Nigeria. It employed a qualitative, multi-method approach to gather empirical data from 13 agile practitioners in Nigeria’s healthcare information systems sector. The study …

Creative Engagement With Ai Through Poetic Inquiry: A Posthuman Pedagogy, Amanda B. Deaton

Feminist Pedagogy

In this article, I describe an original teaching activity that explores the intersection of generative AI, poetic inquiry, and posthuman pedagogy, examining how students can critically and creatively engage with disruptive technologies. Using Rosi Braidotti’s posthuman framework (2013, 2019), I consider how generative AI might be used to challenge traditional notions of creativity, authorship, and knowledge production. Through a structured learning activity, students analyze a human poet’s work, generate AI-assisted poetry, and compose their own creative pieces, fostering non-linearity, memory and imagination, and defamiliarization—three key elements of Braidotti’s posthuman thinking. This pedagogical approach encourages ethical, affirmative engagement with AI, offering …

[Keynote Presentation] Who Owns Our Knowledge? Rethinking Publishing In A Scholar-Led World, Juan Pablo Alperin

Open Access Week Events

The UNI community is invited to attend a lecture by Juan Pablo Alperin, Simon Fraser University. The event is hosted by the Scholarly Communications sections of the three Iowa Regent institutions [Iowa State University, University of Iowa, and University of Northern Iowa].

Details:

• Lecture: "Who owns our knowledge? Rethinking Publishing in a Scholar-Led World," by Juan Pablo Alperin
• Date: Monday, October 20, 2025
• Time: 12 noon (Central Time) to 1 pm
• Location: Room LIB ScholarSpace 301 (Light refreshments) or via Zoom (Registration required)

Description: This presentation will discuss how the proliferation of open access …

Ensuring Ossabaw Island’S Lasting Legacy: Jimmy Carter And The Heritage Trust Act, Ariel Cornett, Cynthia C. Massey, Kathryn L. Haughney, Amanda Wall, Cora Mccaffrey

Teaching Social Studies in the Peach State

These classroom-based activities focus on Jimmy Carter, the Heritage Trust Act, and Ossabaw Island. We developed two short classroom experiences based on Georgia social studies standards with supporting English language arts standards: one classroom experience for second grade and the other for eighth grade. Teachers can adapt content and sequence for their grade levels, schedules, and other school-specific factors. Students will explore the history, culture, and geography of Ossabaw Island, Georgia’s third-largest barrier island. Classroom experiences include different sources, photo analysis, and a range of learning activities with modifications; figures and appendices are included.

Educational Programs For International Students: Present Status, James T. O'Rourke

IGC Proceedings (1977-2023)

A survey was conducted in eight major range science departments in the U.S. to determine the extent of appropriate training for international students, following recommendations made during the past twenty years. The average department was found to have little ability to teach in a language other than English, has few faculty who have worked in a developing country more than one year, and does not equally reward faculty for international work compared with domestic work. Less than 30% of the topics which should occur in international programs of study were actually found in all eight departments. Another 30% of the …

Notice To Employees, Farah Manufacturing Company

Justice for Farah Strikers Committee Records

A notice to Farah Employees detailing future commitments and the return of former employees.