Digital Commons Network^™

Sigrescuer: A Pan-System Framework For Noise Correction And Mutational Signature Identification Across Sequencing Platforms, Peter T. Nguyen, Maria Zhivagui

Nevada Institute of Personalized Medicine Faculty Research

Introduction: Mutational signatures serve as molecular fingerprints of the biological processes and exposures that shape cancer genomes. However, accurate signal recovery remains challenging due to pervasive background variants, sequencing artifacts, technical noise, and platform-specific biases that obscure true mutagenic patterns, hampering biomarker discovery, and mechanistic interpretation. Methods: Here we introduce SigRescueR, a rigorous, pan-system, computational framework based on Bayesian inference designed for noise correction and mutational signature identification. SigRescueR applies statistically robust baseline correction to effectively disentangle true mutational signals from confounding noise and artifacts. Results: When applied to extensive datasets spanning experimental models and human cancers, SigRescueR reliably identified …

Infectious Retinitis Associated With Jak Inhibitors: The Ongoing Duality Of Jak Inhibitors, Jose S. Pulido, Fukutaro Mano, Marcello Casella, Susumu Ishida

Wills Eye Hospital Papers

PURPOSE: To discuss the recent evidence that Janus kinase (JAK) inhibitors can cause viral retinitis.

METHODS: A commentary on the case report in this issue and a review of cases in the literature.

RESULTS: A total of 6 cases have now been reported of cytomegalovirus retinitis associated with Jak inhibitors. Additionally, there was a case of bilateral toxoplasma retinitis and a case of herpetic scleritis.

DISCUSSION: It is important to be aware of the potential blinding complications associated with JAK inhibitors and if the patient complains of acute vision loss and/or floaters, the patient should be emergently referred to a …

2026-03-06 Minutes Of The Executive Committee Of The Academic Senate Senate, University Of Dayton. Academic Senate. Executive Committee

ECAS Minutes

Approved minutes of a meeting of the Executive Committee of the Academic Senate of the University of Dayton.

Negotiating Fatherhood: Young Men’S Narratives Of Care, Responsibility, And Struggle In A Low-Income South African Setting, Urlridge A. Thompson Dr, Tshepang Headman Mr, Leballo Tjemolane Mr, Lukhanyo H. Nyati Dr

Journal of Social, Behavioral, and Health Sciences

Financial provision continues to factor significantly in how Black men perceive and enact fatherhood, influencing the extent and manner of their paternal engagement. The enduring representation of men primarily as financial providers constrains the generation and enactment of alternative modalities of fatherhood within families and society. This qualitative study explored how the everyday lived experiences of young Black men in Soweto, South Africa, influence their varied engagements with fatherhood as they navigate structural constraints to pursuing their ideal of fatherhood. An exploratory descriptive qualitative approach was employed. We conducted two sets of semi-structured interviews with 19 young Black men in …

“I Know He Would Do Anything If I Asked”: To All The Boys I’Ve Loved Before, Female Power Fantasy, And The Ya Romance, Ilse Eskelsen

Undergraduate Honors Theses

The female power fantasy in which a powerless woman conquers a powerful man, thereby symbolically winning his status within the patriarchy for herself, is a classic feature of adult romance. It is visible, too, in YA romances like Jenny Han’s To All the Boys I’ve Loved Before. Sitting in tension with this inheritance from adult romance is the fact that YA is generally expected to be pedagogical, teaching young readers how to live and love well. In blending pedagogy with power fantasy and its associated escapism, To All the Boys essentially upcycles the tropes of adult romance for young …

Patterns Of Recurrent Preterm Birth: An Individual Patient Data Meta-Analysis, Charlotte E. Van Dijk, Annemijn A. De Ruigh, Benjamin Y. Gravesteijn, Brenda M. Kazemier, Vincenzo Berghella, John Owen, Roberto Eduardo Bittar, Rashmi Bagga, Joan M. G. Crane, Andrew H. Shennan, Birgit Arabin, Ben Willem Mol, Eva Pajkrt, C. Emily Kleinrouweler

Department of Obstetrics and Gynecology Faculty Papers

OBJECTIVE: Pregnant patients with a previous spontaneous preterm birth are at high risk for recurrent (spontaneous) preterm birth. We investigated whether the number of previous spontaneous preterm births, gestational age of the previous birth and cervical length could stratify patients into different risk groups for recurrence to investigate whether there is a risk group that does not require additional interventions.

DATA SOURCES: A systematic search of MEDLINE and EMBASE was conducted from 1995 until April 2025.

STUDY ELIGIBILITY CRITERIA: Studies that were included were prospective studies with original individual patient data available that reported on asymptomatic pregnant individuals with ≥1 …

Repair Of Uterine Rupture With Placenta Accreta At 22 Weeks, Followed By Cesarean Hysterectomy Delivery Of Healthy Neonate At 32 Weeks, Molly Dickinson, Thomas Jefferson University, Marco Goldberg, Mae Florendo, Andrew Chau, Corrado Minimo, Kate Stampler, Jay Goldberg

Einstein Health Papers

Introduction: Uterine rupture at previable gestational ages is almost always treated with evacuation of the pregnancy, followed by uterine repair or hysterectomy. Case Presentation: A 40-year-old woman with one prior cesarean section presented at 22 weeks of gestation with an acute abdomen. Imaging noted hemoperitoneum with areas of bulging in the anterior uterine wall. Laparoscopy converted to a laparotomy through a midline incision, noted an actively bleeding 2 cm area of uterine rupture with protruding placental tissue. The uterine rupture was surgically closed with sutures. The patient was kept in the hospital for the remainder of her pregnancy. At 32 …

Risk Decision Making And Intertemporal Choice: Lessons From The Taiwan Strait, Rachel Downing

The US Army War College Quarterly: Parameters

This article argues that domestic and political factors may incentivize US presidents to use risky military options to resolve crises quickly, though high costs or threats to long-term vital interests can overcome leaders’ natural tendencies to focus on the present. Recently declassified documents from President Dwight D. Eisenhower’s administration allow a detailed examination of how US leaders balanced risks over time during the First and Second Taiwan Strait Crises. The findings inform policy recommendations to enhance military planning and enable military advisers to communicate long-term risks more effectively to political leaders.

Book Reviews, Usawc Press

The US Army War College Quarterly: Parameters

No abstract provided.

Spezialpropaganda: The East German Military’S Covert Information-Warfare Program, Joe Cheravitch

The US Army War College Quarterly: Parameters

This article details the East German military’s extensive, innovative covert-propaganda program, which was designed to influence West German attitudes for almost two decades during the Cold War. Unlike existing scholarship that primarily addresses intelligence-led disinformation, this study exclusively analyzes military-led information warfare. The article uses previously classified East German military records to examine capabilities and tactics ranging from fake conscription notices to radio broadcasts. The findings offer contemporary US military planners and practitioners insight into the complexities of integrating information-warfare capabilities, measuring the effectiveness of propaganda, and understanding adversarial influence campaigns, with direct implications for current Joint Force planning and …

Building A Better Landscape For Research Dissemination, Scott Horowitz

Chemistry and Biochemistry: Faculty Scholarship

Let’s take a moment to think about where we’ve come to in scientific publishing. Once upon a time, journals and their publishers played an absolutely critical role in science’s growth and successes.  Many journal publishers are for-profit enterprises, and they still want to make profits even if they no longer serve an important purpose. By controlling the information, they can still force people to pay for services that are obsolete and manipulate the system in ways that stymie progress to maintain their market. Open access did not have the power to change this. Altogether, things are in bad shape. I …

Multi-Stakeholder Perspectives On Barriers To Mental Health Support For Informal Caregivers, Maria Lizette Rangel, Donaji Stelzig, Cassandra Martinez Enriquez, Hoda Badr

Department of Medical Oncology Faculty Papers

BACKGROUND: Informal caregivers experience elevated psychological distress but face substantial challenges in accessing mental health support. Prior research has focused primarily on individual or interpersonal determinants, with less attention to how organizational, community, and policy contexts shape access and contribute to inequities in service availability.

METHODS: Fifty-one stakeholders, including 17 informal caregivers, 23 community health workers (CHWs), and 11 mental health professionals, completed a demographic survey and 60-90-min semi-structured interviews in English or Spanish. Data were analyzed using thematic analysis, combining deductive coding guided by the Socioecological Model with inductive identification of emergent themes.

RESULTS: Participants identified both barriers and …

Sga 57 Senate 2026-03-06 Minutes, Niu Student Government Association Senate

Student Government Association Archives

No abstract provided.

Ai-Driven Mental Health Support For Caregivers Of Individuals With Alzheimer Disease: Systematic Literature Review And Development Of A Conceptual Framework, Sweta Sneha, Chandra Renduchintala, Isa Siddique, Evelina Sterling, Sweta Sneha, Nazmus Sakib

Faculty Articles

Background:Caregivers supporting individuals with Alzheimer disease and related dementias (AD/ADRD) frequently encounter prolonged emotional strain, psychological distress, and social isolation, yet their needs are largely overlooked in current technological and clinical interventions. The special routines and obligations of caregivers of individuals with AD/ADRD are frequently not well-suited to the many artificial intelligence–driven (AI-driven) mental health solutions that are currently available. This reveals a critical need for sophisticated, customized solutions created especially to help the mental health of caregivers for patients with AD/ADRD.

Objective:To address the existing limitations of personalized mental health interventions, we aimed to identify existing literature on personalized …

Cancers 2025: Growing With Quality, Samuel C Mok

Faculty, Staff and Student Publications

As we enter 2026, we take a moment to reflect on the progress of Cancers over the past year [...].

Assessing The Presence Of Biasing And Non-Biasing Unblinding In A Randomized Controlled Trial Of A Home-Use Tdcs Device: An Exploratory Analysis, Fredrik Hieronymus, Nathan T M Huneke, Daniel Månsson, Erik M Rehn, Melker Hagsäter, Rachel D Woodham, Jair C Soares, Allan H Young, Rodrigo M Vieira, Sudhakar Selvaraj, Cynthia Fu

Faculty, Staff and Student Publications

Background: Better-than-chance guessing of treatment assignment raises concerns about unblinding as this opens efficacy estimates up to being influenced by factors other than the true efficacy of the intervention. However, such accuracy does not necessarily indicate that efficacy estimates are biased.

Objective: To assess whether unblinding was biasing (impacting on efficacy estimates) or non-biasing (not impacting on efficacy estimates) in a sham-controlled trial of a home-use transcranial direct-current stimulation (tDCS) device, in which treatment allocation guesses at endpoint were unbalanced.

Methods: Interrelations between i) treatment allocation, ii) treatment allocation guesses, iii) adverse event reports, and iv) depressive symptom severity, as …

2025-12-9 Leadership Team Minutes, Susie Salazar

Executive Council Minutes

No abstract provided.

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

Fluorescent Biosensor-Guided Engineering Of Enzyme Cascades For Electrochemical Applications, Nathan J. Ricks, Monica Brachi, Fnu Arun, Egor Baiarashov, Shelley D. Minteer, Ming C. Hammond

Chemistry Faculty Research & Creative Works

Substrate channeling is a strategy for enhancing flux and yield in enzymatic cascades and is increasingly relevant for applications in biocatalysis, biotechnology, and bioelectrochemical systems. However, efforts to engineer channeling are limited by the lack of high-throughput methods to evaluate and optimize channeling efficiency. Here, we present a fluorescence-based screening assay to rapidly assess substrate channeling in a model system involving fumarase and malate dehydrogenase, two sequential enzymes from the Krebs cycle. By expressing genetic fusions in Escherichia coli, quantifying intermediate (malate) and product (NADH) formation in lysate using orthogonal fluorescent readouts, and comparing product-to-intermediate ratios, we screened a library …

Early Camp Signaling Orchestrates Single-Cell Synchronicity Throughout Dictyostelium Development, Mariko Katoh-Kurasawa, Lena Trnovec, Peter Lehmann, Rui Chen, Yumei Li, Blaž Zupan, Gad Shaulsky

Faculty, Staff and Students Publications

Synchronicity is observed in many biological systems, including development, as seen in vertebrate body axis formation, fly eye development, and development of the social amoeba D. discoideum. Despite its prevalence, quantitative analyses of synchronicity at the single-cell level remain rare. Here we show that synchronicity in D. discoideum is mediated by early cAMP signaling. Using single-cell RNA sequencing (scRNA-seq), we quantify transcriptome similarities between individual cells during development. We show that synchronicity first declines upon starvation but then increases with the onset of cAMP-pulse signaling. Synchronicity remains stable throughout development and differs between prespore and prestalk cells. Genetic perturbations of …

Development Of A Sustainable Blended Food Aid Product Using Local Ingredients For Nutritionally Vulnerable Populations In Haiti, Sherlie Jean Louis Dulience, Rachel Zimmerman, Michelle Dorce, Ilana Seff, Andrea Spray Bulungu, Patricia Kohl, Carolyn Lesorogol, Bazelais Dulience, Lora Iannotti

2020-Current year OA Pubs

OBJECTIVES: This study aimed to: (1) identify optimal blended food recipe options using local flours; (2) assess behaviors, attitudes, and practices around the use of blended foods among nutritionally vulnerable groups in Haiti; and (3) evaluate the nutrient composition of prototype blended food product relative to nutrient requirements for vulnerable populations.

METHODS: Blended food recipes made from local flours were identified through matrix scoring and stakeholder consensus. Focus groups (n = 7) assessed behaviors and attitudes toward blended foods. Prototype recipes were selected based on matrix scoring, program participant feedback, and feasibility of bringing to scale. Nutrient composition of the …

Fragments, Editors Of Fragments

Fragments

No abstract provided.

Fragments, Editors Of Fragments

Fragments

No abstract provided.

Fragments, Editors Of Fragments

Fragments

No abstract provided.

1990s Alt Music Slang And Socioeconomic Precarity In Despentes’ "Vernon Subutex" Series, Daniel J. Lightfoot

Department of French Studies Graduate Student Association Conference

In a time of widespread cynicism and disillusionment with the political and economic status quo in France, how can literature give a voice to those discontents while inspiring hope? My contribution will explore Virginie Despentes’ use of slang from 1990s French alternative music subcultures in her narrative depictions of contemporary economic precarity and social alienation in the Vernon Subutex series (2015-17). I will discuss how Despentes uses French slang to establish a distance between economically marginalized characters and more affluent Parisians, highlighting how the former draw on vocabulary from Anglophone indie rock and hip-hop subcultures as an expression of a …

Fragments, Editors Of Fragments

Fragments

No abstract provided.

Civil Rights And The Edtech Revolution, Kirsten Mettler

Student Journal of Information Privacy Law

Education technology (EdTech) products, like grading software and plagiarism detectors, have increasingly led to concerns over discrimination issues in schools. While, in some instances, schools can be held liable under the federal education civil rights statutes for these harms, that solution is insufficient. EdTech companies should themselves be held responsible. EdTech companies have not historically been understood to fall under these federal statutes, but this Article argues these companies can appropriately be governed by these laws as “recipients” of federal financial assistance. Most EdTech companies should qualify as “recipients” of federal financial assistance under one of three theories: they are …

Research & Debate—Operation Sledgehammer Reconsidered: Disaster Averted Or Opportunity Lost?, Gary Giumarra

Naval War College Review

No abstract provided.

Comic Book Heroes In Theatres: Is “Superhero Fatigue” Real?, Malcolm Summers, The Rattler

The Rattler

Vol. 114 Iss. 1, Opinion

A Music Fantasy: “Tiktok Is Hurting The Music Industry”, Malcolm Summers, The Rattler

The Rattler

Vol. 114 Iss. 1, Opinion