Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 15361 - 15390 of 1439293

Full-Text Articles in Entire DC Network

The “One Big Beautiful Bill” Will Deepen The Farm Crisis, Not Solve It, Rebecca Schewe, Rick Welsh Apr 2026

The “One Big Beautiful Bill” Will Deepen The Farm Crisis, Not Solve It, Rebecca Schewe, Rick Welsh

Center for Policy Research

The One Big Beautiful Bill (OBBB) promises billions in new farm subsidies, but most of that money won’t go to the farmers who need it most. This brief describes how the OBBB’s changes to agricultural subsidy programs will disproportionately benefit large farms and non-farming investors, accelerating farm loss and consolidation across the United States. The authors argue that without reforms, the OBBB will inflate land values, raise barriers for new and small farmers, and further fuel absentee farmland investment. The authors also identify four reforms policymakers should enact to prevent these devastating consequences, including tightening payment limits and closing loopholes, …


Blink & Beat: Pupillometry Response In Autonomic Nervous System Monitoring, Ximena Castillo Apr 2026

Blink & Beat: Pupillometry Response In Autonomic Nervous System Monitoring, Ximena Castillo

2026 Spring Honors Capstones Projects

In the neuroscience intensive care unit (NSICU), nurses rely on advanced monitoring tools to detect neurological deterioration. Two noninvasive measures, heart rate variability (HRV) and pupillary light reflex (PLR), are used to assess autonomic nervous system function; however, it remains unclear whether these indicators provide overlapping or distinct information. The purpose of this observational prospective study is to evaluate the relationship between HRV and quantitative pupillometry measurements to determine whether these noninvasive indicators provide congruent information. Data already collected as routine care from NSICU patients is extracted from the medical record for analysis. Understanding the correlation between HRV and PLR …


The Guardian The Month Of April 2026, Wright State Student Body Apr 2026

The Guardian The Month Of April 2026, Wright State Student Body

The Guardian Student Newspaper

News articles from The Guardian for the Month of April 2026. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.


How Media Framing Impacts Juror Bias In A Fictional Criminal Case, Teah Sharon Swartzon Apr 2026

How Media Framing Impacts Juror Bias In A Fictional Criminal Case, Teah Sharon Swartzon

Journalism

This study examines how media framing influences juror bias among college-aged students when evaluating a defendant's guilt in a fictional criminal case. Utilizing framing theory, the research explores whether biased news coverage can shape perceptions of a defendant's guilt before trial.

Participants, consisting of students at California Polytechnic State University, aged 18-22, were asked to read two news articles about a fictional criminal case. One framed the fictional defendant as guilty, while the other framed him as innocent. Both articles were generated using the Artificial Intelligence Platform, Claude.

Data was collected in a survey where participants indicated whether they believed …


Teeth That Tell Time: Elemental Analysis From Shark Teeth, Gisele-Elizabeth Perez, David Turner Apr 2026

Teeth That Tell Time: Elemental Analysis From Shark Teeth, Gisele-Elizabeth Perez, David Turner

Research Papers

Sharks (Chondrichthyes) have hunted in the oceans for over 400 million years, their teeth leaving history behind, constantly becoming a part of the fossilization process (Worm et al. 2013). Their survival throughout 5 major extinctions is due to their ability to adapt easily with slow metabolism, a wide range of diet, and an efficient physiology. Shark teeth are vital to the hunting and consumption of their prey, making it a point for scientists to study them. Their tooth minerals contain fluorapatite in their enameloid, and dentin in the “root” of the tooth, with extinct species containing dentin and hydroxyapatite in …


Teeth That Tell Time: Elemental Analysis From Shark Teeth, Gisele-Elizabeth Perez Apr 2026

Teeth That Tell Time: Elemental Analysis From Shark Teeth, Gisele-Elizabeth Perez

Posters - 2026

Sharks (Chondrichthyes) have hunted in the oceans for over 400 million years, their teeth leaving history behind, constantly becoming a part of the fossilization process (Worm et al. 2013). Their survival throughout 5 major extinctions is due to their ability to adapt easily with slow metabolism, a wide range of diet, and an efficient physiology. Shark teeth are vital to the hunting and consumption of their prey, making it a point for scientists to study them. Their tooth minerals contain fluorapatite in their enameloid, and dentin in the “root” of the tooth, with extinct species containing dentin and hydroxyapatite in …


Dental Insurance Status Among Formerly Incarcerated Older Adults, Alexander Testa, Rafael Samper-Ternent, Dylan B Jackson, Kyle T Ganson, Vahed Maroufy, Jason M Nagata, Ana C Neumann Apr 2026

Dental Insurance Status Among Formerly Incarcerated Older Adults, Alexander Testa, Rafael Samper-Ternent, Dylan B Jackson, Kyle T Ganson, Vahed Maroufy, Jason M Nagata, Ana C Neumann

Faculty, Staff and Student Publications

Formerly incarcerated individuals have poorer oral health and less frequent dental care utilization than the general population. However, prior work has overlooked the relationship between prior incarceration and disparities in dental insurance coverage. Using data from the Health and Retirement Study (n = 11,638), findings from multiple logistic regression analyses demonstrate that formerly incarcerated older adults are significantly less likely to have dental insurance coverage (odds ratio [OR] = 0.745, 95% confidence interval [CI] = 0.608, 0.912). After accounting for the income-to-poverty ratio, this association was no longer statistically significant. Analyses using the Karlson-Holm-Breen method demonstrated that approximately 45% of …


Sexual Health And Relationship Education Needs Of People In Recovery For An Opioid Use Disorder, J Michael Wilkerson, Kathryn R Gallardo, I Niles Zoschke, Hannah L N Stewart, Serena A Rodriguez, Michael U Anosike, Jason Pullin, Sheryl A Mccurdy Apr 2026

Sexual Health And Relationship Education Needs Of People In Recovery For An Opioid Use Disorder, J Michael Wilkerson, Kathryn R Gallardo, I Niles Zoschke, Hannah L N Stewart, Serena A Rodriguez, Michael U Anosike, Jason Pullin, Sheryl A Mccurdy

Faculty, Staff and Student Publications

People in recovery with histories of sex and drug-linked behavior (SDB) have an increased risk of substance use recurrence. However, sexual health concerns remain largely unaddressed by recovery support services researchers and practitioners. The purpose of this analysis was to describe the sex and relationship concerns of people in recovery for an opioid use disorder living in level II and level III recovery homes. Recovery homes are sober living homes that the National Association for Recovery Residences classifies into four levels based on staffing and service provision. We interviewed 93 residents and thematically analyzed 92 of the resulting transcripts; one …


Robo2 Variants Associated With Atrial Septal Defect Define A Novel Regulatory Element, Seong Won Kim, Michael Parfenov, Laura Rodriguez-Murillo, David A Conner, Arun Sharma, Inga Peter, Feng Xiao, Olivia Layton, Angela Tai, Tarsha Ward, Lauren K Wasson, Joshua M Gorham, Erica Mazaika, Valentina N Lagomarsino, Tracy L Young-Pearse, Elizabeth Goldmuntz, Hiroko Wakimoto, A J Agopian, David M Mckean, Steven R Depalma, William T Pu, Christine E Seidman, Bruce D Gelb, Jonathan G Seidman Apr 2026

Robo2 Variants Associated With Atrial Septal Defect Define A Novel Regulatory Element, Seong Won Kim, Michael Parfenov, Laura Rodriguez-Murillo, David A Conner, Arun Sharma, Inga Peter, Feng Xiao, Olivia Layton, Angela Tai, Tarsha Ward, Lauren K Wasson, Joshua M Gorham, Erica Mazaika, Valentina N Lagomarsino, Tracy L Young-Pearse, Elizabeth Goldmuntz, Hiroko Wakimoto, A J Agopian, David M Mckean, Steven R Depalma, William T Pu, Christine E Seidman, Bruce D Gelb, Jonathan G Seidman

Faculty, Staff and Student Publications

Background: Atrial septal defects (ASDs) are a prevalent type of congenital heart disease. Previous GWAS (Genome-Wide Association Studies) have identified common variants associated with ASDs, though their mechanisms remain unknown. We aimed to expand insights into the architecture of common variants associated with ASD risk and elucidate functional mechanisms.

Methods: We conducted a GWAS using isolated ASD cases and healthy controls and replicated findings in an independent cohort. We examined epigenetic marks within this ASD locus in human induced pluripotent stem cell-derived cardiomyocytes and fetal human hearts. We characterized the consequences of deletions introduced by CRISPR-Cas9 mutagenesis of human induced …


Developing Scenario-Based Strategies For Health, Climate, And Environmental Preparedness: The One Health, One Earth Approach, Azar M Abadi, Kyle D Brumfield, Moiz Usmani, Gemma Jiang, T C Chakraborty, Yuzhou Wang, Zhijie Zhou, Cenlin He, Minghao Qiu, Jennifer D Stowell, Douglas Fritz, Sunil Kumar, Qiang Guo, Ying Xiong, Georgia Destouni, Qian Xiao, Xindi C Hu, Kelvin C Fong, Yun Hang, John Nielsen-Gammon, Rima Habre, Jennifer R Bratburd, Christopher W Tessum, Antarpreet Jutla, Rita R Colwell, Gabriel M Filippelli, Thanh H Nguyen Apr 2026

Developing Scenario-Based Strategies For Health, Climate, And Environmental Preparedness: The One Health, One Earth Approach, Azar M Abadi, Kyle D Brumfield, Moiz Usmani, Gemma Jiang, T C Chakraborty, Yuzhou Wang, Zhijie Zhou, Cenlin He, Minghao Qiu, Jennifer D Stowell, Douglas Fritz, Sunil Kumar, Qiang Guo, Ying Xiong, Georgia Destouni, Qian Xiao, Xindi C Hu, Kelvin C Fong, Yun Hang, John Nielsen-Gammon, Rima Habre, Jennifer R Bratburd, Christopher W Tessum, Antarpreet Jutla, Rita R Colwell, Gabriel M Filippelli, Thanh H Nguyen

Faculty, Staff and Student Publications

Climate change amplifies many threats to human health. Despite advances in understanding climate change dynamics and impacts, there remains a critical gap in translating scientific knowledge into equitable, and community‐driven health interventions. The inaugural One Earth, One Health workshop sought to explore this gap through human‐centered design exercises involving interdisciplinary researchers from climate and Earth sciences, engineering, epidemiology, microbiology, and environmental health. Although participants did not co‐develop solutions with affected communities, they used stakeholder role‐playing to guide ideation and lay groundwork for actionable plans. Through these methods, participants identified community needs and proposed prototype solutions to alleviate health threats …


The All-Payer Claims Database After The Gobeille Supreme Court Decision: Assessing The Impact On Fatal Opioid-Related Overdose Research, Jack Cordes, Cici Bauer, Dana Bernson, Marc R Larochelle, Wenjun Li, Jiahao Cao, Olaf Dammann, Thomas J Stopka Apr 2026

The All-Payer Claims Database After The Gobeille Supreme Court Decision: Assessing The Impact On Fatal Opioid-Related Overdose Research, Jack Cordes, Cici Bauer, Dana Bernson, Marc R Larochelle, Wenjun Li, Jiahao Cao, Olaf Dammann, Thomas J Stopka

Faculty, Staff and Student Publications

Objective: To determine the consequences of the Gobeille v. Liberty Mutual Supreme Court decision on the representativeness of the Massachusetts all-payer claims database (APCD). The loss of individuals captured in the APCD may vary demographically, geographically, and in the capture of fatal opioid-related overdose (OOD).

Data sources and study setting: We used 2013-2021 data from the Massachusetts Public Health Data Warehouse (PHD), which links person-level APCD records to other datasets. The APCD includes commercially-insured health claims mandatorily reported pre-Gobeille. Post-Gobeille, reporting from self-insured plans, a subset of commercially-insured plans, became voluntary.

Study design: In a repeated cross-sectional design, we compared …


The Internal Motivation Of English Language Learners To Acquire The Language, Milos Slaninka Apr 2026

The Internal Motivation Of English Language Learners To Acquire The Language, Milos Slaninka

Doctor of Education (Ed.D)

This case study utilized qualitative research to investigate how the adult education program at a school in a northeastern state’s English as a second language (ESL) program affected the students’ intrinsic motivation. Students’ recruitment followed the principle of homogenous sampling, which entailed choosing a small number of the population that fit the study’s parameters. As a result, the data collection for the study consisted of interviews with 11 individuals enrolled in the ESL program. All interviews were carried out in the interviewee’s private setting via the Zoom platform to ensure the collection of the most genuine data possible. The main …


El Leñador, April 2026, El Leñador Staff Apr 2026

El Leñador, April 2026, El Leñador Staff

El Leñador Newspaper

El Leñador is an English and Spanish newspaper produced by Humboldt State University students. Our staff cover and provide news to Latinx and other diverse communities on campus and in Humboldt County. We are committed to providing relevant news and expanding the representations and stories told about people of color and other marginalized groups. Our work helps create more social, political and cultural diversity in local media.

El Leñador es un periodico en español y inglés producido por estudiantes de la Universidad Estatal de Humboldt. Nuestro personal cubre y provee noticias a la comunidad Latinx y otras comunidades diversas en …


A Culture Divided: How Irish Americans Responded To Ireland’S Wartime Neutrality, Robert J. Barron Apr 2026

A Culture Divided: How Irish Americans Responded To Ireland’S Wartime Neutrality, Robert J. Barron

Honors College Theses

In the Second World War, the nation of Ireland declared its neutrality and maintained this status through the course of the long conflict. Meanwhile, Germany, Great Britain, and eventually the United States all competed to gain Ireland’s support in the war. However, one overlooked group continued to keep tabs on the affairs within their homeland: Irish Americans. How does one respond to a nation you have a connection with staying neutral in such a deadly conflict? The answer, for Irish Americans, was that it depended on the year. Before the United States entered the war, Irish Americans firmly defended the …


Conflict As Catalyst: The Role Of Conflict In Creating Political Space For Women, Christie S. Warren Apr 2026

Conflict As Catalyst: The Role Of Conflict In Creating Political Space For Women, Christie S. Warren

Faculty Publications

Although the benefits associated with the presence of women in political decision-making positions are uncontested, global statistics relating to the number of women in political leadership roles paint a disappointing picture of underutilized resources. While rights-based advocacy, quotas, and economic incentives are commonly posited as effective strategies to increase the number of women active in public spaces, several studies have shown that the law alone is not sufficient to bring about changes in gender norms unless the underlying structural constructs that perpetuate inequalities privileging dominant groups are addressed first. Conflict, especially when driven by rejection of those inequalities, can hasten …


Is It Credit?, Jim Hawkins Apr 2026

Is It Credit?, Jim Hawkins

William & Mary Law Review

Earned wage access companies advance money to workers based on wages they have already earned but have not yet been paid. Then, one of three things happens to reimburse the earned wage access provider: (1) the worker’s employer sends the provider money directly, (2) the provider withdraws money from the worker’s bank account on payday, or (3) nothing. The last of these is the most interesting. If the earned wage access provider does not receive the funds from the worker’s employer or bank account, the worker just walks away. Even more remarkable, many providers do not charge any mandatory fees …


Key Components Of An Effective Gifted Program, Amanda Fjeld Apr 2026

Key Components Of An Effective Gifted Program, Amanda Fjeld

Master's Theses & Capstone Projects

This inquiry-based research project aimed to identify the essential components of an effective gifted education program. The study examined which factors of a gifted pull-out program impact student learning through identifying consistent patterns. A mixed-methods approach was used. Qualitative and quantitative data were gathered on program structures, instructional approaches, and teacher preparedness. This study gathered information from peer-reviewed articles and survey responses from four Iowa gifted educators. The results revealed that while there are consistencies across many pull-out programs, there are many different goals. Key themes that were identified in gifted programs include 21st-century skill development, project-based learning, and social-emotional …


The Impact Of Culturally Responsive And Inclusive Instructional Practices, Avril Baccam Apr 2026

The Impact Of Culturally Responsive And Inclusive Instructional Practices, Avril Baccam

Master's Theses & Capstone Projects

Culturally responsive and inclusive instructional practices are essential for supporting student engagement and participation in increasingly diverse elementary classrooms. However, some second-grade students do not experience equitable opportunities to engage in learning due to instructional practices that may not fully address cultural, linguistic, and learning differences. This inquiry-based research study aimed to examine second-grade teachers' perceptions of culturally responsive and inclusive instructional practices and their impact on student engagement and participation. The study also explored which instructional strategies teachers identify as most effective for promoting equitable engagement among diverse learners. A mixed-methods approach was utilized, including quantitative survey data and …


Schoolwide Pbis And Its Influence On Engagement And Discipline For Students With Disabilities, Morgan Peterson Apr 2026

Schoolwide Pbis And Its Influence On Engagement And Discipline For Students With Disabilities, Morgan Peterson

Master's Theses & Capstone Projects

Positive Behavior Interventions and Supports (PBIS) is a framework adopted by schools to proactively teach and reinforce expected and prosocial student behaviors. The framework is implemented across three tiers and provides opportunities for data collection to support decision-making at each level of intervention. PBIS emphasizes clear behavioral expectations, consistent reinforcement, and systematic responses to behavior within a schoolwide system (Simonsen et al., 2022; Meyer et al., 2021). Previous research suggests that when PBIS is implemented across all three tiers, the use of exclusionary disciplinary practices decreases for all students, with particularly notable effects for students with disabilities who are supported …


Using Play-Based Learning To Support Early Academic-Related Learning Behaviors: A Case Study In An Early Childhood Classroom, Tracy Montalvo Apr 2026

Using Play-Based Learning To Support Early Academic-Related Learning Behaviors: A Case Study In An Early Childhood Classroom, Tracy Montalvo

Master's Theses & Capstone Projects

This inquiry-based research study examined how play-based learning supports early academic-related learning behaviors for an individual child in a preschool early childhood special education (ECSE) classroom. The purpose of this study was to understand how engagement, persistence, and problem-solving developed over time through play-based experiences and teacher facilitation. Data were collected over a four-week period using multiple tools, including structured observation checklists, frequency and duration recording sheets, anecdotal field notes, and reflective journal entries. The findings of this study suggest that play-based learning supported the development of early academic-related learning behaviors, as the child demonstrated increased engagement, improved persistence, and …


The Impact Of Mindfulness Strategies In An Elementary Classroom, Trinity Lawless Apr 2026

The Impact Of Mindfulness Strategies In An Elementary Classroom, Trinity Lawless

Master's Theses & Capstone Projects

School districts across the globe have adopted social-emotional initiatives throughout their schools to better the mental health of students and instill crucial soft skills within them. Implementing mindfulness strategies is one way that teachers are helping their students become more emotionally self-regulated learners. Although there is a plethora of research surrounding mindfulness, research on the specific mindfulness strategies that work best and the ones that students prefer is missing from the existing research. To mend this research gap, the current researcher sought to discover how mindfulness strategies impact students’ overall mindfulness score, what strategies are most beneficial, and which strategies …


Explicit Phonological Awareness Vs. Classroom Literacy Instruction, Aaron Sue Grahlman Apr 2026

Explicit Phonological Awareness Vs. Classroom Literacy Instruction, Aaron Sue Grahlman

Master's Theses & Capstone Projects

The study explored the effectiveness of explicit phonological awareness instruction compared with traditional classroom literacy instruction in supporting early reading development among kindergarten students, particularly those at risk for reading difficulties. Drawing on Formative Assessment System for Teachers (FAST) data from two cohorts, the results showed varying degrees of difference in overall reading proficiency between the two instructional approaches. These findings indicate that while both approaches support student literacy growth, early, systematic instruction in phonological awareness yields more rapid initial gains and a higher proportion of students meeting benchmarks. These findings suggest that implementing targeted phonological strategies can lead to …


The Impact Of Structured Reflective Journaling On Self-Efficacy In Early-Career Teachers, Ashley Van Dusseldorp Apr 2026

The Impact Of Structured Reflective Journaling On Self-Efficacy In Early-Career Teachers, Ashley Van Dusseldorp

Master's Theses & Capstone Projects

Teacher self-efficacy is a critical factor influencing instructional effectiveness, classroom management, and teacher retention, yet many educators in their first five years of teaching report low confidence in their professional abilities as they navigate the complexities of the classroom. This lack of confidence can negatively impact instructional decision-making, classroom practices, and long-term commitment to the profession. The purpose of this inquiry-based research study was to examine the impact of a structured reflective journaling intervention on the self-efficacy of new teachers with fewer than five years of teaching experience. Using a mixed-methods design, participants completed pre- and post-intervention self-efficacy surveys and …


Improving Bullying Victimization And Supports For Autistic Students, Sidney Swanson Apr 2026

Improving Bullying Victimization And Supports For Autistic Students, Sidney Swanson

Master's Theses & Capstone Projects

Bullying and peer victimization remain persistent concerns for students with autism spectrum disorder (ASD), who experiences higher rates of peer exclusion, rejection, and social isolation than their neurotypical peers. These experiences can negatively affect school engagement, emotional well-being, peer relationships, and long-term mental health outcomes. This practitioner inquiry study examined how classroom based social emotional learning (SEL) and inclusion strategist influenced peer relationships, student belonging, and bullying related behaviors for students with autism in an elementary school setting. This study was conducted over a six-week period in one first grade general education classroom and one Strat II ID/ LD classroom …


Co-Teaching Classroom Management And Relationships: Impact On Ell Student Engagement And Achievement In 5th Grade Ela, Jesse Strong Apr 2026

Co-Teaching Classroom Management And Relationships: Impact On Ell Student Engagement And Achievement In 5th Grade Ela, Jesse Strong

Master's Theses & Capstone Projects

This study examines how co-teaching influences English Language Learner (ELL) engagement, behavior, teacher-student relationships, and academic achievement in a fifth-grade ELA classroom. As classrooms become more diverse, teachers need strategies that support language development while still holding students to grade-level expectations. Co-teaching, where a general education teacher works alongside a support teacher, allows for shared planning, instruction, and assessment to better meet student needs. The purpose of this study was to explore how different co-teaching approaches affect student engagement, confidence, classroom behavior, and learning outcomes. Data were collected through classroom observations, student work and performance data, and teacher reflections. Findings …


Transfusion In Transit: A Decade Of Prehospital Blood Transfusion In Pediatric Trauma, Krysta M Sutyak, Eunise C Chen, Lea Mock, Rudolfo Cabrera, Jeannette M Joly, Kuojen Tsao, Bryan A Cotton, David E Meyer, Charles S Cox, Kevin P Lally, Natalie A Drucker Apr 2026

Transfusion In Transit: A Decade Of Prehospital Blood Transfusion In Pediatric Trauma, Krysta M Sutyak, Eunise C Chen, Lea Mock, Rudolfo Cabrera, Jeannette M Joly, Kuojen Tsao, Bryan A Cotton, David E Meyer, Charles S Cox, Kevin P Lally, Natalie A Drucker

The Brown Foundation: Institute of Molecular Medicine

Background: Prehospital blood transfusion improves mortality in adults, with limited evidence in children. This study describes prehospital blood transfusion in pediatric trauma patients and the impact on shock index, pediatric adjusted (SIPA).

Methods: This study is a retrospective cohort study of trauma patients younger than 18 years who received blood transfusions during helicopter transport to a Level 1 pediatric trauma center from 2011 to 2023. Primary outcome was change in SIPA at time of emergency department (ED) arrival with prehospital transfusion. Secondary subgroup analysis was performed based on transport origin.

Results: Of 137 patients, 58% (80 of 137 patients) were …


Affinity-Optimized Trop2 Antibodies Support Potent Antitumor Activity In Antibody-Drug Conjugates, Aiko Yamaguchi, Junping Hong, Leike Li, Kiyotaka Kobayashi, Chisato M Yamazaki, Summer Y Y Ha, Yasuaki Anami, Wei Xiong, Junquan Liu, Zhiqiang An, Ningyan Zhang, Kyoji Tsuchikama Apr 2026

Affinity-Optimized Trop2 Antibodies Support Potent Antitumor Activity In Antibody-Drug Conjugates, Aiko Yamaguchi, Junping Hong, Leike Li, Kiyotaka Kobayashi, Chisato M Yamazaki, Summer Y Y Ha, Yasuaki Anami, Wei Xiong, Junquan Liu, Zhiqiang An, Ningyan Zhang, Kyoji Tsuchikama

The Brown Foundation: Institute of Molecular Medicine

Background: Trophoblast cell surface antigen 2 (TROP2) is frequently overexpressed in epithelial tumors and is associated with poor prognosis, making it an attractive therapeutic target. Antibody-drug conjugates (ADCs) directed against TROP2 show clinical benefit, but expression in normal tissues such as skin raises concerns about on-target, off-tumor toxicity. Strategies that improve antitumor efficacy without increasing toxicity are needed.

Methods: Using an in-house phage library, we identified and characterized a novel fully human monoclonal antibody recognizing a unique conformational epitope of TROP2 with reduced binding affinity. This antibody was engineered into homogeneous ADCs carrying auristatin and/or duocarmycin payloads. Comparative studies with …


Telomerase Knockout In Myeloid Cells Predisposes Mice To Foam Cell Formation, Dyslipidemia, Lung Fibrosis, And Cardiac Dysfunction, Zhanguo Gao, Yongmei Yu, David Wiggins, Eva M Sevick-Muraca, Mikhail G Kolonin Apr 2026

Telomerase Knockout In Myeloid Cells Predisposes Mice To Foam Cell Formation, Dyslipidemia, Lung Fibrosis, And Cardiac Dysfunction, Zhanguo Gao, Yongmei Yu, David Wiggins, Eva M Sevick-Muraca, Mikhail G Kolonin

The Brown Foundation: Institute of Molecular Medicine

Aging-associated changes in myeloid cells are incompletely understood. One of the culprits of aging is the downregulation of the Tert gene coding for the catalytic subunit of telomerase. Studies of mouse models with Tert knockout (KO) in specific cells have revealed the importance of the telomere-independent noncanonical function of TERT in supporting mitochondrial metabolism and protection from cell senescence. To investigate the role of TERT in myeloid cells (MCs), we analyzed mice with Tert KO in the LysM+ lineage, indelibly labeled with membrane green fluorescent protein (mG). Macrophage numbers and properties in various organs were compared. Changes in the vasculature, …


Availability Of Cancer Screening Across Hiv Treatment Sites In The Iedea Consortium, Rachael Pellegrino, Bryan Shepherd, Sanjay Pujari, Valeria Fink, Gad Murenzi, Miriam Nakalembe, Sally Coburn, Eliane Rohner, Antoine Jaquet, Elkanah Orang'o Apr 2026

Availability Of Cancer Screening Across Hiv Treatment Sites In The Iedea Consortium, Rachael Pellegrino, Bryan Shepherd, Sanjay Pujari, Valeria Fink, Gad Murenzi, Miriam Nakalembe, Sally Coburn, Eliane Rohner, Antoine Jaquet, Elkanah Orang'o

Obstetrics and Gynaecology, East Africa

Cancer remains a leading cause of morbidity and mortality in people with HIV, and the importance of cancer screening increasesas this population ages. In 2017, 2020, and 2023, cross-sectional surveys were conducted at HIV care sites across 5 continentswithin the International epidemiology Databases to Evaluate AIDS (IeDEA) consortium. We described cancer screening avail-ability in 2023 and over time for cervical and anal cancer screening using generalized estimating equations with a logit linkfunction to account for site clustering, rurality, and country income. Of the 220 sites in the 2023 survey, 61% (134/220) reportedcervical cancer screening by cytology or human papillomavirus (HPV) …


Availability Of Cancer Screening Across Hiv Treatment Sites In The Iedea Consortium, Rachael Pellegrino, Bryan Shepherd, Sanjay Pujari, Valeria Fink, Gad Murenzi, Miriam Nakalembe, Sally Coburn, Eliane Rohner, Antoine Jaquet, Elkanah Orang'o Apr 2026

Availability Of Cancer Screening Across Hiv Treatment Sites In The Iedea Consortium, Rachael Pellegrino, Bryan Shepherd, Sanjay Pujari, Valeria Fink, Gad Murenzi, Miriam Nakalembe, Sally Coburn, Eliane Rohner, Antoine Jaquet, Elkanah Orang'o

Obstetrics and Gynaecology, East Africa

Cancer remains a leading cause of morbidity and mortality in people with HIV, and the importance of cancer screening increasesas this population ages. In 2017, 2020, and 2023, cross-sectional surveys were conducted at HIV care sites across 5 continentswithin the International epidemiology Databases to Evaluate AIDS (IeDEA) consortium. We described cancer screening avail-ability in 2023 and over time for cervical and anal cancer screening using generalized estimating equations with a logit linkfunction to account for site clustering, rurality, and country income. Of the 220 sites in the 2023 survey, 61% (134/220) reportedcervical cancer screening by cytology or human papillomavirus (HPV) …