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Articles 12661 - 12690 of 1439293
Full-Text Articles in Entire DC Network
Mild Thermal Treatment Of Lithium-Ion Batteries To Optimize Black Mass Production, Brooke Lillie
Mild Thermal Treatment Of Lithium-Ion Batteries To Optimize Black Mass Production, Brooke Lillie
Theses and Dissertations
This thesis explains the design of equipment and the experimental procedure for thermal treatment of lithium-ion batteries for the purpose of low-cost materials recycling. Conditions used were between 150 ℃ and 425 ℃, involving different atmospheric conditions and treatment durations. The battery samples were processed through a sieve shaker device. Mass loss during the heat treatment, and separation of the battery through sieving was used to analyze the effect of the treatments on separability of black mass from the batteries. Additionally, internal battery temperature was measured and compared to real average furnace temperature to monitor thermal runaway. Testing showed minimal …
The Artificial Maintenance Of Relationship Satisfaction: Romantic Ai Companion Usage Sustains Emerging Adults' Human Romantic Relationship Satisfaction While Eroding Relationship Stability, Rebekah M. Hakala
Theses and Dissertations
As artificial intelligence becomes increasingly sophisticated, romantic AI companions--AI systems designed to simulate romantic, emotional, or sexual relationships--have emerged as a novel relational phenomenon. Nearly one in four emerging adults now engage with romantic AI companions, yet little is known about how this usage affects their romantic human relationships. Drawing on Social Exchange Theory and the Investment Model of Commitment, and employing structural equation modeling, this thesis uses data from 2,431 emerging adults in romantic relationships to examine whether romantic AI companion usage influences relationship satisfaction and relationship stability among emerging adults in the United States (ages 18-30), and whether …
Impacts Of Arbuscular Mycorrhizal Fungi And Novel Soil Amendments On Perennial Grass Establishment In Mineland Soils, Melissa M. Burrell
Impacts Of Arbuscular Mycorrhizal Fungi And Novel Soil Amendments On Perennial Grass Establishment In Mineland Soils, Melissa M. Burrell
Theses and Dissertations
Establishing perennial vegetation on mine waste materials is one of the primary challenges in mine land reclamation. Waste rock and mine tailing substrates typically lack the physical structure, nutrient availability, and biological communities necessary to support plant establishment and long-term ecosystem recovery. As a result, revegetation efforts often experience poor seeding success and limited plant persistence despite intensive management efforts. These studies investigated two complementary strategies to improve perennial grass establishment in degraded mine substrates: restoring mycorrhizal associations and enhancing soil function through soil amendments. The first study examined the role of arbuscular mycorrhizal fungi (AMF) in facilitating plant establishment …
The 12-Week Silence: A Scrollytelling Investigation Into Early Pregnancy Loss And The Case For Continuous Progesterone Monitoring, Audrey Gold
FHSS Mentored Research Conference
Opens with the scale of the problem (up to 1M miscarriages annually, all in the most data-poor window of pregnancy), describes the methodology (2 original surveys, 4 clinical interviews, peer-reviewed literature), walks through what the piece does visually (the distribution curve, the blind-spot timeline, the 5-phase progesterone chart, the intervention pathway), and closes with the central argument — that the silence is a gap in technology, not an inevitability.
Historical Claims And Environmental Harms: How Historical Analogues Can Be Utilized To Show Injury-In-Fact In Environmental Cases, Julia Landi
Seton Hall Law Review
No abstract provided.
The Myth Of Homespun, Valeria Delaportilla
The Myth Of Homespun, Valeria Delaportilla
Undergraduate Scholarly Works
In this work, delaPortilla analyzes the Homespun Movement, a boycott largely led by women during the American Revolution that encouraged the use of homespun fabrics to avoid purchasing fabrics from Europe. DelaPortilla argues that the homespun movement was not as widespread as existing historiography allows us to believe and explains that the movement was largely limited to people of means who could afford to commit to a fully homespun lifestyle. DelaPortilla further argues that the forceful application of the homespun movement in New England largely contributed to the mass criticism and in some occasions abuse of women.
Florida Police Officers’ Reflections On Faith And Spirituality Through Lived Experiences, Steven Vose Mcgillicuddy
Florida Police Officers’ Reflections On Faith And Spirituality Through Lived Experiences, Steven Vose Mcgillicuddy
Walden Dissertations and Doctoral Studies
This qualitative phenomenological study examined how Florida police officers perceived changes in their spiritual and religious beliefs following prolonged exposure to critical incidents. The research question asked how officers interpreted, adapted, and transformed their spiritual or religious beliefs in response to repeated critical incident exposure. Nine sworn frontline officers participated and were interviewed using a semi structured protocol. Transcripts were analyzed inductively using thematic analysis. Three primary findings emerged: (1) Career and Impact captured cumulative occupational exposure that prompted moral appraisal and coping, and participants did not report uniform loss of faith; (2) Spiritual Belief followed three common trajectories—stability, strengthening/reaffirmation, …
April 21, 2026 Ereporter, University Of Alabama At Birmingham
April 21, 2026 Ereporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
Awareness, Protest, And Action: Women Science-Fiction Writers As Writer Activists, Carolyn Nolte
Awareness, Protest, And Action: Women Science-Fiction Writers As Writer Activists, Carolyn Nolte
Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–
Following the end of World War II, science-fiction literature, which was mostly dominated by white male writers, experienced an increase in stories written by women writers. Of these postwar stories written by women, the three women writers in this dissertation imagined how their present-day experiences informed the future by exploring their concerns about humanity’s collective trajectory. By analyzing how their stories dramatize possible future social, psychological, biological, and environmental harms, this dissertation argues that these women writers’ works distinguish them as writer-activists, a concept I borrow from Rob Nixon’s work Slow Violence and the Environmentalism of the Poor.
I …
There Is Strength In Numbers: The Case For Another Model Of Cardiometabolic Hfpef, Sadia Ashraf, Hunter A Hidalgo, Romain Harmancey
There Is Strength In Numbers: The Case For Another Model Of Cardiometabolic Hfpef, Sadia Ashraf, Hunter A Hidalgo, Romain Harmancey
Faculty, Staff and Student Publications
No abstract provided.
Opportunistic Breast Cancer Detection With Photon-Counting Ct: A Quantitative Pilot Study Of Reconstruction-Dependent Image Quality, Graham Hannon
Opportunistic Breast Cancer Detection With Photon-Counting Ct: A Quantitative Pilot Study Of Reconstruction-Dependent Image Quality, Graham Hannon
McKelvey School of Engineering Graduate Student Theses & Dissertations
Photon-counting computed tomography (PCCT) has emerged as a promising imaging modality with improved spatial resolution and contrast capabilities compared to conventional energy-integrating detector systems. These advantages present an opportunity for opportunistic detection of breast cancer in routine thoracic CT scans that include breast tissue. In this pilot study, we evaluated the feasibility of opportunistic breast cancer detection using clinical PCCT data through quantitative image analysis. Two patients with confirmed breast malignancies and corresponding thoracic PCCT scans were retrospectively analyzed. Dedicated reconstructions were performed with varying convolution kernels, field-of-view sizes, and virtual monoenergetic spectra. Image quality was assessed using signal-to-noise ratio …
Three Papers On The Impacts Of Electoral Rules On The Behavior Of Politicians, Jordon Tyler Newton
Three Papers On The Impacts Of Electoral Rules On The Behavior Of Politicians, Jordon Tyler Newton
Arts & Sciences Graduate Student Theses and Dissertations
This dissertation is composed of three papers that examine the ways that electoral rules may provide elites incentives that cut against citizen interests. In the first, titled ``Maybe Later: Term Limits and Strategy Behind Candidate Entry," I use the context of term limits to reexamine conditions for candidate entry. I argue they reduce the number of candidates who challenge incumbents, leading to a lock-in effect. By increasing the frequency of open races, term limits incentivize potential challengers to wait for an open race. To demonstrate this, I analyze primary data from 85 legislative chambers in 44 states over a two-decade …
Development And Flight Of Stratospheric Missions For Hard X-Ray Polarimetry And Hard X-Ray Spectroscopy, Ephraim Gau
Development And Flight Of Stratospheric Missions For Hard X-Ray Polarimetry And Hard X-Ray Spectroscopy, Ephraim Gau
Arts & Sciences Graduate Student Theses and Dissertations
The recent launches of the {\it Imaging X-ray Polarimetry Explorer} ({\it IXPE}\,) and {\it XRISM} have provided significant advances to the realms of polarization and high-resolution spectroscopy in X-ray astrophysics. However, both of these satellite missions conduct measurements in the soft X-rays, below 10 keV. To obtain a complete picture of any astrophysical source, we must extend these capabilities to the hard X-rays, above 10 keV, as well. Thus, in my graduate work, I have directed my efforts in these two regimes: measuring the polarization of hard X-rays with {\it XL-Calibur}, and improving the energy resolution of hard X-ray telescopes …
The Place We Live Which Does Not Exist, Jonathon Parker Yontz
The Place We Live Which Does Not Exist, Jonathon Parker Yontz
Electronic Theses and Dissertations 2020 - Present
The Place We Live Which Does Not Exist is a collection of stories examining the intersection of trauma and catharsis through a psychologically manufactured underground environment. By inhabiting the perspectives of multiple characters, each story builds toward a collective reality that exists parallel to our present. As the shortsightedness of hedonistic expression is shown, the viability of escapism as panacea is questioned, exploring the ends of a society increasingly dependent on reclusive tendencies.
Some Closure On The Relation Between Cfg And Peg, Nathan J. Bulloch
Some Closure On The Relation Between Cfg And Peg, Nathan J. Bulloch
Theses and Dissertations
We work toward a practical, unified language formalism for structurally recursive languages by expressing the mathematical theories underlying context-free grammars with lookahead (CFGLA) in the Rocq theorem prover and leveraging CFGLA semantics to analyze interactions between between recursion and negative lookahead. We give examples of grammars with left-recursive negation cycles for the parsing expression grammar (PEG) variant due to Medeiros et al. and for the translation from PEG to CFGLA due to Miyazaki and Minamide. To study the interaction between left recursion and negative lookahead in a PEG context, we introduce FPEG, a left-recursive extension of PEG with Fitting semantics.
Changes In Internet Search Term Popularity In Elder Mistreatment (2018-2023): Infodemiology Study Of Google Trends Data, Nicholas Sevey, Melvin Livingston, Kristin Lees-Haggerty, Olanike Ojelabi, Randi Campetti, Jason Burnett, Carolyn E Z Pickering, David Hancock, Rachit Sabharwal, Michael Brad Cannell
Changes In Internet Search Term Popularity In Elder Mistreatment (2018-2023): Infodemiology Study Of Google Trends Data, Nicholas Sevey, Melvin Livingston, Kristin Lees-Haggerty, Olanike Ojelabi, Randi Campetti, Jason Burnett, Carolyn E Z Pickering, David Hancock, Rachit Sabharwal, Michael Brad Cannell
Faculty, Staff and Student Publications
Background: Elder mistreatment (EM) is a significant public health problem that is frequently underdetected and underreported. Insufficient public recognition and engagement have been hypothesized as one contributor to this underreporting; however, few data sources exist to quantify public awareness or engagement with EM at the population level.
Objective: This study examined relative internet search interest in EM compared with other forms of abuse (child abuse and domestic violence) in the United States using Google Trends data.
Methods: We analyzed Google Trends data to compare the Relative Search Index (RSI) for the terms "elder abuse," "child abuse," and "domestic violence" in …
Illinois Valley Central High School Wind Ensemble And Symphonic Band: April 21, 2026, Matthew Chapman, Lauren N. Bobarsky, Colby Powers
Illinois Valley Central High School Wind Ensemble And Symphonic Band: April 21, 2026, Matthew Chapman, Lauren N. Bobarsky, Colby Powers
School of Music Programs
This is the one hundred and eighty-fourth program of the 2025-2026 season.
Center for the Performing Arts
April 21, 2026
Tuesday Evening
8:00 p.m.
Templating Effect Of Neutral Dithiane Ligands On The Self-Assembly Of Cationic Au(I)-Phosphine Units, Farzane Osanlou, Abdollah Neshat, Mohammad Reza Yousefshahi, Vaclav Eigner, Michal Dusek, Shahram Seidi
Templating Effect Of Neutral Dithiane Ligands On The Self-Assembly Of Cationic Au(I)-Phosphine Units, Farzane Osanlou, Abdollah Neshat, Mohammad Reza Yousefshahi, Vaclav Eigner, Michal Dusek, Shahram Seidi
Turkish Journal of Chemistry
The interactions between the dinuclear Au(I) precursor (dppm)Au2Cl2 and neutral sulfur-containing dithianes (specifically 1,3- and 1,4-dithiane) were examined in the presence of NH₄PF₆. Although these sulfur-based ligands were initially employed to facilitate the formation of mixed phosphine/sulfur Au(I) complexes, single-crystal X-ray diffraction analysis revealed the unexpected generation of multinuclear Au(I) assemblies exclusively coordinated by phosphine ligands. When 1,3-dithiane was present, a trinuclear Au(I) complex was isolated, characterized by a central four-coordinate Au(I) center exhibiting a distorted see-saw geometry, flanked by two terminal Au(I) centers with T-shaped coordination environments. Importantly, the dithiane ligand did not coordinate directly to the gold centers …
The Hate Circuit: A Collection Of Essays On Hate And Healing, Vivian Murphy
The Hate Circuit: A Collection Of Essays On Hate And Healing, Vivian Murphy
Electronic Theses and Dissertations 2020 - Present
The Hate Circuit: A Collection of Essays on Hate and Healing is a lyric essay collection tracing the neuroscience, psychology, and lived experience of hatred and its slow unraveling. Rooted in the author’s relationship with her alcoholic mother, the essays move between memoir and scientific inquiry, examining how hatred forms in the brain, how it is inherited across generations, and what it costs to sustain it. Drawing on research in neuroscience, attachment theory, and the psychology of forgiveness, the collection argues that hatred is not simply an emotion but a circuit—one that can, with effort, be rewired. The essays ultimately …
The Scholastic Trombone Ensemble: Instructional Guide And Custom Arrangements For Secondary School Trombone Choir, Cassidy Clayton Shiflett-Cockrell
The Scholastic Trombone Ensemble: Instructional Guide And Custom Arrangements For Secondary School Trombone Choir, Cassidy Clayton Shiflett-Cockrell
Electronic Theses and Dissertations Archive
ABSTRACT The trombone ensemble is an increasingly popular academic tool for young collegiate players to cultivate musicianship and ensemble skills. Because this setting exclusively uses trombones, it is excellent for training intonation, resonance, and overall blend. I was first introduced to performing in a trombone ensemble during my undergraduate studies at the University of North Alabama through a trombone quartet. The time I spent learning to listen and blend with my colleagues was foundational to developing the critical ensemble skills I still use frequently. Throughout my following studies at The University of Akron and the University of Memphis, respectively, the …
Be Trauma Informed: A Pilot Evaluation Of A Podcast Intervention To Improve Trauma-Informed Care Knowledge, Attitudes, And Practices Among Pediatric Critical Care Nurses, Elizabeth Devries
Be Trauma Informed: A Pilot Evaluation Of A Podcast Intervention To Improve Trauma-Informed Care Knowledge, Attitudes, And Practices Among Pediatric Critical Care Nurses, Elizabeth Devries
Dissertations (1934 -)
Trauma-informed care (TIC) is integral to pediatric critical care (PCC) but accessible, scalable education is limited. This mixed-methods pilot study developed and evaluated Be Trauma Informed, a two-episode podcast educational series designed to increase PCC nurses’ TIC knowledge, attitudes, and trauma-informed practices while also assessing implementation outcomes of feasibility, necessity, acceptability, fidelity, safety, and beginning effectiveness. The curriculum for the podcast series was developed by the primary investigator with stakeholder input from PCC and TIC experts. The podcast was professionally produced, and episodes were distributed on major podcast platforms. Using purposive convenience sampling, PCC nurses within the United States completed …
Using Chatgpt Ai To Analyze Clinical Judgment In Immersive Virtual Reality Simulation From Prelicensure Nursing Students, Shari Ann Fehrenbach
Using Chatgpt Ai To Analyze Clinical Judgment In Immersive Virtual Reality Simulation From Prelicensure Nursing Students, Shari Ann Fehrenbach
Dissertations (1934 -)
This retrospective, descriptive study examined how clinical judgment was demonstrated across two immersive virtual reality simulation (IVRS) experiences in a cohort of Direct Entry Master of Science in Nursing (DEMSN) students using a generative large language model artificial intelligence, ChatGPT, for categorization of clinical judgment cognitive processes. The National Council of State Boards of Nursing (NCSBN) Clinical Judgment Measurement Model (CJMM) guided the study (NCSBN, 2022). Nurse expert-derived CJMM-aligned scoring rubrics were applied to deidentified, developer-generated IVRS performance reports, and ChatGPT categorized whether rubric actions were demonstrated and generated case-level, scored excel files. Total CJMM and cognitive component scores were …
Prodromal Lewy Body Disorder Features In Rem Sleep Behavior Disorder With Biomarker-Defined Synucleinopathy, Daniel Weintraub, Michele K York, Roseanne Dobkin, Anuprita R Nair, Ryan Kurth, David-Erick Lafontant, Chelsea Caspell-Garcia, Roy N Alcalay, Ethan G Brown, Lana M Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M Tanner, Thomas F Tropea, Aleksandar Videnovic, Parkinson's Progression Markers Initiative
Prodromal Lewy Body Disorder Features In Rem Sleep Behavior Disorder With Biomarker-Defined Synucleinopathy, Daniel Weintraub, Michele K York, Roseanne Dobkin, Anuprita R Nair, Ryan Kurth, David-Erick Lafontant, Chelsea Caspell-Garcia, Roy N Alcalay, Ethan G Brown, Lana M Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M Tanner, Thomas F Tropea, Aleksandar Videnovic, Parkinson's Progression Markers Initiative
Faculty, Staff and Students Publications
Objective: Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker-defined synucleinopathy.
Methods: Parkinson's Progression Markers Initiative (PPMI) is a longitudinal, multi-center observational study. Participants included polysomnogram (PSG)-confirmed iRBD individuals who were cerebrospinal fluid (CSF) α-synuclein seed amplification assay positive with no clinical diagnosis of Parkinson's disease or dementia with Lewy bodies, along with robust healthy controls (HCs). Clinical and biological features of prodromal PD and DLB, including mild cognitive impairment (MCI), subthreshold …
Development Of Telenutrition Education And Counseling Protocol To Improve Diet Quality In Individuals With Spinal Cord Injury, Adrianne Widaman, Benjamin Dirlikov, Ramya Gopalan, Shelley Wood, Maria Sol Casas, Kazuko Shem
Development Of Telenutrition Education And Counseling Protocol To Improve Diet Quality In Individuals With Spinal Cord Injury, Adrianne Widaman, Benjamin Dirlikov, Ramya Gopalan, Shelley Wood, Maria Sol Casas, Kazuko Shem
Faculty Research, Scholarly, and Creative Activity
Background: Cardiometabolic disease (CMD) is a leading cause of death for individuals living with chronic spinal cord injury (SCI), with a mortality rate due to CMD being higher than individuals without SCI. Telenutrition (TN) interventions tailored to health and accessibility needs of individuals with SCI may mitigate cardiometabolic risks. Objectives: To describe the development and validation of a telehealth-based medical nutrition therapy (MNT) within a clinical trial investigating the effectiveness of modifying diets to improve cardiometabolic health in persons with chronic SCI. Methods: The adaptive module-based MNT education content was developed in 3 phases by a multidisciplinary team. The first …
Cardiovascular Disease And Dyslipidemia In Pediatric Type 1 Diabetes, Grace K Kim, Preneet Cheema Brar, Nidhi Bansal
Cardiovascular Disease And Dyslipidemia In Pediatric Type 1 Diabetes, Grace K Kim, Preneet Cheema Brar, Nidhi Bansal
Faculty, Staff and Students Publications
Purpose of review
Despite advances in type 1 diabetes (T1D) management, mortality is still increased, with cardiovascular disease (CVD) as the leading cause. Dyslipidemia is a highly prevalent modifiable CVD risk factor. We reviewed the existing literature on CVD mortality in T1D to highlight CVD risk in pediatric patients with T1D.
Recent findings
Pathophysiology of T1D and premature CVD risk is still not fully understood. Dyslipidemia remains a highly prevalent and undertreated CV risk factor in T1D. Statins have been shown to be safe and effective to improve CVD risk in adults with T1D, and in children with familial hypercholesterolemia, …
Obstructive Sleep Apnea Treatment Modifies The Effectiveness Of Catheter Ablation For Atrial Fibrillation: Post Hoc Analysis Of The Cabana Trial, Matthew W Segar, Kaleb D Lambeth, Brett Doliner, Joshua R Hirsch, Abdi Rasekh, Mehdi Razavi
Obstructive Sleep Apnea Treatment Modifies The Effectiveness Of Catheter Ablation For Atrial Fibrillation: Post Hoc Analysis Of The Cabana Trial, Matthew W Segar, Kaleb D Lambeth, Brett Doliner, Joshua R Hirsch, Abdi Rasekh, Mehdi Razavi
Faculty, Staff and Students Publications
No abstract provided.
Designing Next-Generation Cardiometabolic Outcome Trials For Obesity Medicines, Elke Platz, Alexander Peikert, Biykem Bozkurt, Bart Van Der Schueren, Javed Butler, Ildiko Lingvay, Darren K Mcguire, Faiez Zannad, Naveed Sattar
Designing Next-Generation Cardiometabolic Outcome Trials For Obesity Medicines, Elke Platz, Alexander Peikert, Biykem Bozkurt, Bart Van Der Schueren, Javed Butler, Ildiko Lingvay, Darren K Mcguire, Faiez Zannad, Naveed Sattar
Faculty, Staff and Students Publications
The prevalence of obesity has reached pandemic proportions and is having enormous public health effects. Obesity increases the risk of type 2 diabetes, hypertension, chronic kidney disease, and cardiovascular (CV) disease including coronary artery disease, heart failure, atrial fibrillation, and stroke. Although initial randomized clinical trials of weight-loss strategies through diet and exercise or early medical therapies did not lead to improved CV outcomes, more recent trials using glucagon-like peptide-1 (GLP-1) receptor agonists in individuals with obesity have demonstrated CV benefits. At present, there are multiple cardiovascular outcome trials (CVOTs) of novel GLP-1 receptor agonists and investigational products targeting multiple …
Rhesus Macaques With An Opa1 Mutation Demonstrate Features Of Autosomal Dominant Optic Atrophy, Tracy N Jaggers, Ana Ripolles-Garcia, Ala Moshiri, Brett D Story, Jun Wang, Rui Chen, Lucy G Moore, Leandro B C Teixeira, Jaeho Shim, Ana C Raposo, Maria Isabel Casanova, Sophie M Le, Sangwan Park, Laura J Young, Soohyun Kim, Karolina P Roszak, Vanessa Ureno, Paige M Karpinen, Nayeli Echeverria, Monica Ardon, Brian C Leonard, Marguerite Knipe, Eliza Bliss-Moreau, Brad Fortune, J Timothy Stout, Jeffrey Rogers, Nicholas Marsh-Armstrong, Sara M Thomasy
Rhesus Macaques With An Opa1 Mutation Demonstrate Features Of Autosomal Dominant Optic Atrophy, Tracy N Jaggers, Ana Ripolles-Garcia, Ala Moshiri, Brett D Story, Jun Wang, Rui Chen, Lucy G Moore, Leandro B C Teixeira, Jaeho Shim, Ana C Raposo, Maria Isabel Casanova, Sophie M Le, Sangwan Park, Laura J Young, Soohyun Kim, Karolina P Roszak, Vanessa Ureno, Paige M Karpinen, Nayeli Echeverria, Monica Ardon, Brian C Leonard, Marguerite Knipe, Eliza Bliss-Moreau, Brad Fortune, J Timothy Stout, Jeffrey Rogers, Nicholas Marsh-Armstrong, Sara M Thomasy
Faculty, Staff and Students Publications
Autosomal dominant optic atrophy (ADOA) is an inherited optic neuropathy primarily caused by mutations in OPA1. We identified and defined a spontaneous nonhuman primate (NHP) model of ADOA using rhesus macaques heterozygous for a missense mutation (OPA1A8S). With ocular examinations, ophthalmic imaging, electroretinography, histopathology, immunohistochemistry, and transmission electron microscopy (TEM), we documented retinal nerve fiber layer (RNFL) thinning, retinal ganglion cell (RGC) loss and dysfunction, OPA1 mislocalization, and reduced axonal mitochondrial density in affected macaques. Our investigation revealed substantial phenotypic variability among affected macaques, shedding light on the pathogenesis of ADOA. The retinas were evaluated using techniques …
Out-Of-Pocket Costs And Antihypertensive Medication Use Among Veterans: A Natural Experiment, Alexander R. Zheutlin, Alexander Chaitoff, Daniel Addo, Joshua A. Jacobs, Catherine G. Derington, Eric L. Stulberg, Peter A. Glynn, Bernardo Modenesi, Jordana B. Cohen, Adam P. Bress
Out-Of-Pocket Costs And Antihypertensive Medication Use Among Veterans: A Natural Experiment, Alexander R. Zheutlin, Alexander Chaitoff, Daniel Addo, Joshua A. Jacobs, Catherine G. Derington, Eric L. Stulberg, Peter A. Glynn, Bernardo Modenesi, Jordana B. Cohen, Adam P. Bress
Department of Neurology Faculty Papers
BACKGROUND: Blood pressure (BP) control remains suboptimal in the United States despite available low-cost antihypertensive medications. Even small out-of-pocket medication costs may contribute to adherence. We determined whether $0 versus >$0 out-of-pocket costs for antihypertensive medications is associated with differences in adherence, discontinuation, BP control, and cardiovascular outcomes.
METHODS: We included veterans with newly diagnosed hypertension who initiated antihypertensive medication in the Veterans Health Administration from 2004 to 2022. A fuzzy regression discontinuity design with 2-stage residual inclusion leveraged differences in medication copay policy at a 50% service-connected disability threshold (≥50% service-connected disability: $0 out-of-pocket cost versus < 50%: $8 monthly cost). Outcomes included 1-year medication nonadherence (proportion of days covered < 80%), 1-year medication discontinuation (no medication in the final 90 days of the study year), 1-year BP control (systolic BP/diastolic BP < 140/90 mm Hg and < 130/80 mm Hg) and cardiovascular disease events (myocardial infarction, coronary revascularization, peripheral artery disease, or stroke).
RESULTS: Among 417 …