Digital Commons Network^™

Neural Epigenetic Changes In Response To Morphine: A Peek Into The Science Of Addiction, Timothy Smartt, Jeffrey Edwards, Addison Smartt

Library/Life Sciences Undergraduate Poster Competition 2024

Introduction

Since the 1990's, the United States has experienced a crisis of opioid addiction and overdose. The effects of opioids on the ventral tegmental area (VTA), the reward center of the brain, are a primary cause of opioid dependence.

Distinguishing Leukemic Cells Using Fractal Chromatin Patterns And Machine Learning, Abigail Gordhamer, Ryan Cordner, Paul Young

Library/Life Sciences Undergraduate Poster Competition 2024

One of the most important tests in the clinical laboratory is the Complete Blood Count, which involves identifying the white blood cells in a patient’s blood. The respective counts of the different white blood cell types correlate with various states of health and disease and are critical to diagnosing diseases such as leukemia. Leukemic cells (blasts) are considered especially difficult to distinguish, and it is of the upmost importance that these cells are identified correctly. To aid in the process of leukemic cell identification, we quantified fractal patterns in the chromatin of white blood cells and used the data to …

Spartan Daily, March 21, 2024, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2024

Volume 162, Issue 25

Technical Data Package For Sysmlv2 Vignettes, Allen W. Dukes

Student Publications

This Technical Data Package (TDP) thoroughly compiles instructions, concepts, and solutions for eight SysMLv2 vignettes. Each vignette illustrates methods to solve complex system modeling challenges. The initial concept for each vignette can drive the use and evaluation of a custom SysMLv2 modeling tool as shown in [1]. They can support a baseline set of tasks to compare usability with other SysMLv2 modeling software tools.

The document starts with three pairs of vignettes for modeling a hypothetical Unmanned Aerial Vehicle (UAV) operated with a Virtual Reality (VR) headset derived from AFIT WKSP 696. The final pair of vignettes focus on two …

Quantitative Shotgun Proteomic Analysis Of Bacteria After Overexpression Of Recombinant Spider Miniature Spidroin, Masp1, Kathryn Randene, J. Alexander H. Mendoza, Michael Ysit, Craig Vierra

Pacific Faculty Work

Spider silk has extraordinary mechanical properties, displaying high tensile strength, elasticity, and toughness. Given the high performance of natural fibers, one of the long-term goals of the silk community is to manufacture large-scale synthetic spider silk. This process requires vast quantities of recombinant proteins for wet-spinning applications. Attempts to synthesize large amounts of native size recombinant spidroins in diverse cell types have been unsuccessful. In these studies, we design and express recombinant miniature black widow MaSp1 spidroins in bacteria that incorporate the N-terminal and C-terminal domain (NTD and CTD), along with varying numbers of codon-optimized internal block repeats. Following spidroin …

Ultrasound Imaging Of Abductor Hallucis Volume Demonstrated By Strong Agreement With Mri, Jacob Willes, Aaron W. Johnson

Library/Life Sciences Undergraduate Poster Competition 2024

Due to the complexity of assessing the individual strength and function of certain deep small muscles within the body such intrinsic foot muscles, ultrasound (US) and magnetic resonance imaging (MRI) may provide a means to appropriately evaluate these muscles. Assessing foot muscles using US and MRI provides a unique and important model to compare muscle volume. Since intrinsic foot muscles are crucial for function and mobility while influencing quality of life, being able to accurately measure foot muscle volume is important. For example, the tracking of atrophy or hypertrophy due to disease or therapeutic intervention. While MRI is often considered …

Brief Of Children’S Rights Advocates In Support Of Appellees: Held V. Montana, Asha Brundage-Moore, Wyatt Sassman, Catherine Smith

Scholarly Articles

Amici Curiae are members of the Consortium for the Advancement of Children’s Constitutional Rights and Healthy Mothers, Heathy Babies: The Montana Coalition who are children’s rights advocates and legal scholars. Amici submit this brief to: (1) highlight Montana’s Constitution as a leader in advancing children’s constitutional rights; (2) draw this Court’s attention to the Montana Constitution’s text and history recognizing children’s right to a clean and healthful environment; and (3) explain that a decision not to safeguard children’s right to a clean and healthful environment in reliance on adult-centric analytical missteps advanced by Appellants (and supporting Amici) would deny Montana’s …

In Re: Ocugen, Inc. Securities Litigation

2024 Decisions

USDC for the Eastern District of Pennsylvania

Troy Moore,Sr. V. Saajida Walton

2024 Decisions

USDC for the Eastern District of Pennsylvania

Jenn-Ching Luo V. Owen J Roberts School District

2024 Decisions

USDC for the Eastern District of Pennsylvania

Gartor Brown V. Maxwell

2024 Decisions

USDC for the Middle District of Pennsylvania

Sherry Norris V. Nlmk Pennsylvania Llc

2024 Decisions

USDC for the Western District of Pennsylvania

Calisia Kelley V. Brian O\'Malley

2024 Decisions

USDC for the Western District of Pennsylvania

Calisia Kelley V. Brian O\'Malley

2024 Decisions

USDC for the Western District of Pennsylvania

Estimating Polarization Purity With Noise, Alex Kostinski, Dan Kestner, Jothiram Vivekanandan

Michigan Tech Publications

We formulate a problem of estimating and monitoring mismatch (unwanted departure from orthogonality) of two ostensibly orthogonal polarization channels in a fully polarimetric general device such as a polarimetric weather radar. A statistical approach is proposed by using thermal noise or, more generally, a 'polarimetric noise' class of sources. The suitable noise class of distributions is shown to be rooted in the complex multivariate Gaussian probability density function (pdf), the latter possessing a uniform pdf on the Poincare sphere (PS), with a probability measure given by a fractional surface area. To that end, we develop a parameter to estimate polarization …

Lepocreadiidae (Trematoda) Associated With Gelatinous Zooplankton (Cnidaria And Ctenophora) And Fishes In Australian And Japanese Waters, Thomas H. Cribb, Scott C. Cutmore, Nicholas Q.-X. Wee, Joanna G. Browne, Pablo Diaz Morales, Kylie A. Pitt

Harold W. Manter Laboratory of Parasitology: Library Materials

We examined gelatinous zooplankton from off eastern Australia for lepocreadiid trematode metacercariae. From 221 specimens of 17 species of cnidarian medusae and 218 specimens of four species of ctenophores, infections were found in seven cnidarian and two ctenophore species. Metacercariae were distinguished using cox1 mtDNA, ITS2 rDNA and morphology. We identified three species of Prodistomum Linton, 1910 [P. keyam Bray & Cribb, 1996, P. orientale (Layman, 1930), and Prodistomum Type 3], two species of Opechona Looss, 1907 [O. kahawai Bray & Cribb, 2003 and O. cf. olssoni], and Cephalolepidapedon saba Yamaguti, 1970. Two species were found in cnidarians …

The Gyrokinetic Dispersion Relation Of Microtearing Modes In Collisionless Toroidal Plasmas, Benjamin D G Chandran, A A. Schekochihin

Faculty Publications

We solve the linearized gyrokinetic equation, quasineutrality condition and Ampere's law to obtain the dispersion relation of microtearing modes (MTMs) in collisionless low- $\beta$ toroidal plasmas. Consistent with past studies, we find that MTMs are driven unstable by the electron temperature gradient and that this instability drive is mediated by magnetic drifts. The dispersion relation that we derive can be evaluated numerically very quickly and may prove useful for devising strategies to mitigate MTM instability in fusion devices.

Mechanical Properties Of A Structural Component Processed In High-Pressure Die Casting (Hpdc) With A Non-Heat-Treated Aluminum Alloy, David Servando Cantú-Fernández, Jaime Taha-Tijerina, Alejandro González, Pablo Guajardo Hernández, Brian Quinn

Informatics and Engineering Systems Faculty Publications

This industrial research focuses on the implementation and development of a productive process for an automotive structural component (Shock tower) manufactured by a high-pressure die casting (HPDC) process made of aluminum alloy AuralTM-5. This aluminum alloy has been considered in diverse automotive and aerospace components that do not require heat treatment due to its mechanical properties as cast material (F temper). On the other hand, AuralTM-5 has been designed for processing as HPDC because it is an alloy with good fluidity, making it ideal for large castings with thin-wall thicknesses, like safety structural components such as rails, supports, rocker panels, …

Investigating The Use Of Finerenone In Children With Chronic Kidney Disease And Proteinuria: Design Of The Fiona And Open-Label Extension Studies., Franz Schaefer, Giovanni Montini, Hee Gyung Kang, Johan Vande Walle, Joshua Zaritsky, Michiel F. Schreuder, Mieczyslaw Litwin, Andrea Scalise, Helen Scott, James Potts, Pablo Iveli, Stefanie Breitenstein, Bradley A. Warady

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Proteinuria is a modifiable risk factor for chronic kidney disease (CKD) progression in children. Finerenone, a selective, non-steroidal, mineralocorticoid receptor antagonist (MRA) has been approved to treat adults with CKD associated with type 2 diabetes mellitus (T2DM) following results from the phase III clinical trials FIDELIO-DKD (NCT02540993) and FIGARO-DKD (NCT02545049). In a pre-specified pooled analysis of both studies (N = 13,026), finerenone was shown to have an acceptable safety profile and was efficacious in decreasing the risk of adverse kidney and cardiovascular outcomes and of proteinuria.

OBJECTIVE: FIONA and the associated open-label extension (OLE) study aim to demonstrate that …

The Homotopy Cardinality Of The Representation Category, Justin Murray

LSU Doctoral Dissertations

Given a Legendrian knot in (R^3, ker(dz − ydx)) one can assign a combinatorial invariants called ruling polynomials. These invariants have been shown to recover not only a (normalized) count of augmentations but are also closely related to a categorical count of augmentations in the form of the homotopy cardinality of the augmentation category. In this article, we prove that that the homotopy cardinality of the n-dimensional represen- tation category is a multiple of the n-colored ruling polynomial. Along the way, we establish that two n-dimensional representations are equivalent in the representation category if they are “conjugate homotopic”. We also …

Exploring Extended Reality In An Aqueous Processing Test Bed For Nuclear Material, Sam Wald

Undergraduate Honors Theses

This research aided in the ongoing creation of an extended reality training experience for Beartooth, an aqueous processing test bed for nuclear material, by exploring what will be comfortable and effective for users of the experience. Participants consisted of staff members from Idaho National Laboratory (INL) and authorized members of the Augmented Learning Lab at BYU. We conducted usability testing with participants who were given extended reality (XR) equipment to explore the Beartooth virtual training system. We also performed a heuristic evaluation on the system using an augmented reality evaluation checklist. Findings were discussed with the INL team and recommendations …

Inclusion Teachers' Perceived Barriers To Meeting The Academic Needs Of Students With Disabilities, Caren Renee Carey

Walden Dissertations and Doctoral Studies

No abstract provided.

Second Inflection Point Of Supercooled Water Surface Tension Induced By Hydrogen Bonds: A Molecular-Dynamics Study, Fawaz Hrahsheh, Inshad Jum'h, Gerald Wilemski

Physics Faculty Research & Creative Works

Surface Tension Of Supercooled Water Is A Fundamental Property In Various Scientific Processes. In This Study, We Perform Molecular Dynamics Simulations With The TIP4P-2005 Model To Investigate The Surface Tension Of Supercooled Water Down To 220 K. Our Results Show A Second Inflection Point (SIP) In The Surface Tension At Temperature TSIP ≈ 267.5 ± 2.3 K. Using An Extended IAPWS-E Functional Fit For The Water Surface Tension, We Calculate The Surface Excess Internal-Energy And Entropy Terms Of The Excess Helmholtz Free Energy. Similar To Prior Studies [Wang Et Al., Phys. Chem. Chem. Phys. 21, 3360 (2019); Gorfer Et Al., …

Tumor Treating Fields Suppress Tumor Cell Growth And Neurologic Decline In Models Of Spinal Metastases, Daniel Ledbetter, Romulo Augusto Andrade De Almeida, Xizi Wu, Ariel Naveh, Chirag B Patel, Queena Gonzalez, Thomas H Beckham, Robert North, Laurence Rhines, Jing Li, Amol Ghia, David Aten, Claudio Tatsui, Christopher Alvarez-Breckenridge

Faculty, Staff and Student Publications

Spinal metastases can result in severe neurologic compromise and decreased overall survival. Despite treatment advances, local disease progression is frequent, highlighting the need for novel therapies. Tumor treating fields (TTFields) impair tumor cell replication and are influenced by properties of surrounding tissue. We hypothesized that bone's dielectric properties will enhance TTFields-mediated suppression of tumor growth in spinal metastasis models. Computational modeling of TTFields intensity was performed following surgical resection of a spinal metastasis and demonstrated enhanced TTFields intensity within the resected vertebral body. Additionally, luciferase-tagged human KRIB osteosarcoma and A549 lung adenocarcinoma cell lines were cultured in demineralized bone grafts …

Reconceptualizing Museum Decolonization: A Proposal For The Repatriation Of Agency, Bacci Francesca

All Works

This paper discusses how cultural governance leadership can adopt a decolonizing operational model for museums, to the advantage of all stakeholders. Key to the proposed framework is foregrounding the repatriation of ex-colonies’ agency as preparatory to the possible repatriation of their objects. The model hypothesizes the creation of an international alliance of museums, ministries of culture and universities/research institutes to form an accrediting body that certifies the status of “decolonized museum”, with appointed national curators or community representatives from each former colony. These professionals can be temporarily hired by institutions worldwide, to support the writing, displaying and storytelling revisions necessary …

Stare Decisis And Remedy, Melissa Murray

Duke Law Journal

Much ink has been spilled on the Roberts Court’s approach to stare decisis and precedent. Such commentary is hardly surprising. In just the last five years, the Court has overruled extant precedents on issues that range from abortion and jury convictions to property rights and public unions. It has also substantially narrowed and limited existing precedents, curbing the reach of earlier decisions in ways that disrupt and distort the jurisprudential landscape.

Some view the Court’s uneven approach to precedent as ideologically determined. As these critics maintain, the Court adheres to precedents that are consistent with the views of its six-member …

The Return Of Three-Judge Constitutional Courts, Matt Queen

Duke Law Journal

State courts wield the authority to elevate state constitutional protections above those afforded by the U.S. Constitution. That power is great—so great that some legislatures have intervened in constitutional adjudication, purportedly to undermine forum shopping and check a single judge’s influence. Accordingly, North Carolina and Tennessee require that three-judge trial courts hear constitutional challenges to state laws. These courts echo twentieth-century congressional efforts to trim federal courts’ equitable jurisdiction. They also present new and familiar drawbacks spawned by their federal ancestors.

This Note examines these new constitutional courts through several lenses: their historical context, political development, advantages, and drawbacks. Although …

Fighting Utility Wildfire With Knowledge Management, Catherine J.K. Sandoval

Duke Environmental Law & Policy Forum

No abstract provided.

Healthcare Overspend – Valuable Insights From A Hands-On Assessment And Chiropractic Care For Uninterrupted Cervicogenic Headaches: A Case Report, Jessy Johnson, Michael Mcqueen, Eric J. Kirk, Christopher Arick

Aurora GME

No abstract provided.

Bold Group, Llc V. Rachmut

All Decisions

In a residential landlord-tenant action, the tenant successfully defended against eviction by establishing a prima facie case of a rent-impairing violation, specifically a roof leak. The court found that the landlord's evidence to refute the violation was weak. However, the court also denied the tenant's request for attorney fees and security deposit return.