Digital Commons Network^™

Himrod St. Assoc., L.P. V. Andrews

All Decisions

In a non-payment case settled with a payment agreement, the tenant's government agency (HRA) sent checks to the landlord, but one went missing. The court ruled the landlord couldn't evict the tenant for the missing amount because it likely went to someone with access to the landlord's checks. Even though the payee (landlord) usually bears the risk of internal fraud, the court considered the hardship of eviction and the government agency's resources for investigating the missing funds.

Doubly Charged Dimers And Trimers Of Heavy Noble Gases, Gabriel Schöpfer, Stefan Bergmeister, Milan Ončák, Ianessa Stromberg, Masoomeh Mahmoodi-Darian, Paul Scheier, Olof Echt, Elisabeth Gruber

Faculty Publications

Many doubly charged heteronuclear dimers are metastable or even thermodynamically stable with respect to charge separation. Homonuclear dicationic dimers, however, are more difficult to form. He₂²⁺ was the first noble gas dimer predicted to be metastable and, decades later, observed. Ne₂²⁺ is the only other dicationic noble gas dimer that has been detected so far. Here, we present a novel approach to form fragile dicationic species, by post-ionization of singly charged ions that are embedded in helium nanodroplets (HNDs). Bare ions are then extracted by colliding the HNDs with helium gas. We detect homonuclear doubly charged …

The Gyrokinetic Dispersion Relation Of Microtearing Modes In Collisionless Toroidal Plasmas, Benjamin D G Chandran, A A. Schekochihin

Faculty Publications

We solve the linearized gyrokinetic equation, quasineutrality condition and Ampere's law to obtain the dispersion relation of microtearing modes (MTMs) in collisionless low- $\beta$ toroidal plasmas. Consistent with past studies, we find that MTMs are driven unstable by the electron temperature gradient and that this instability drive is mediated by magnetic drifts. The dispersion relation that we derive can be evaluated numerically very quickly and may prove useful for devising strategies to mitigate MTM instability in fusion devices.

The Difference Between Males And Females In First Language Acquisition, Haya Alotaibi

Sociology Between the Gaps: Forgotten and Neglected Topics

No abstract provided.

If1 Promotes Cellular Proliferation And Inhibits Oxidative Phosphorylation In Mouse Embryonic Fibroblasts Under Normoxia And Hypoxia, Lothar Lauterboeck, Sung Wook Kang, Donnell White, Rong Bao, Parnia Mobasheran, Qinglin Yang

School of Graduate Studies Faculty Publications

ATP synthase inhibitory factor subunit 1 (IF1) is an inhibitory subunit of mitochondrial ATP synthase, playing a crucial role in regulating mitochondrial respiration and energetics. It is well-established that IF1 interacts with the F1 sector of ATP synthase to inhibit the reversal rotation and, thus, ATP hydrolysis. Recent evidence supports that IF1 also inhibits forward rotation or the ATP synthesis activity. Adding to the complexity, IF1 may also facilitate mitophagy and cristae formation. The implications of these complex actions of IF1 for cellular function remain obscure. In the present study, we found that IF1 expression was markedly upregulated in hypoxic …

The Past As A Colonialist Resource, Deepa Das Acevedo

Duke Law Journal

Originalism’s critics have failed to block its rise. For many jurists and legal scholars, the question is no longer whether to espouse originalism but how to espouse it. This Article argues that critics have ceded too much ground by focusing on discrediting originalism as either bad history or shoddy linguistics. To disrupt the cycle of endless “methodological” refinements and effectively address originalism’s continued popularity, critics must do two things: identify a better disciplinary analogue for originalist interpretation and advance an argument that moves beyond methods.

Anthropology can assist with both tasks. Both anthropological analysis and originalist interpretation are premised on …

Gut Microbiota Composition Is Associated With The Efficacy Of Delta-24-Rgdox In Malignant Gliomas, Natalie M Meléndez-Vázquez, Teresa T Nguyen, Xuejun Fan, Andrés R López-Rivas, Juan Fueyo, Candelaria Gomez-Manzano, Filipa Godoy-Vitorino

Faculty, Staff and Student Publications

Glioblastoma, the most common primary brain tumor, has a 6.8% survival rate 5 years post diagnosis. Our team developed an oncolytic adenovirus with an OX-40L expression cassette named Delta-24-RGDOX. While studies have revealed the interaction between the gut microbiota and immunotherapy agents, there are no studies linking the gut microbiota with viroimmunotherapy efficacy. We hypothesize that gut bacterial signatures will be associated with oncolytic viral therapy efficacy. To test this hypothesis, we evaluated the changes in gut microbiota in two mouse cohorts: (1) GSC-005 glioblastoma-bearing mice treated orally with indoximod, an immunotherapeutic agent, or with Delta-24-RGDOX by intratumoral injection and …

Correction: Detecting The Percent Of Peripheral Blood Mononuclear Cells Displaying P-Stat-3 In Malignant Glioma Patients, William Humphries, Yongtao Wang, Wei Qiao, Chantal Reina-Ortiz, Mohamed K Abou-Ghazal, Lamonne M Crutcher, Jun Wei, Ling-Yuan Kong, Raymond Sawaya, Ganesh Rao, Jeffrey Weinberg, Sujit S Prabhu, Gregory N Fuller, Amy B Heimberger

Faculty, Staff and Student Publications

No abstract provided.

Gut Microbiota Composition Is Associated With The Efficacy Of Delta-24-Rgdox In Malignant Gliomas, Natalie M Meléndez-Vázquez, Teresa T Nguyen, Xuejun Fan, Andrés R López-Rivas, Juan Fueyo, Candelaria Gomez-Manzano, Filipa Godoy-Vitorino

Faculty, Staff and Student Publications

Glioblastoma, the most common primary brain tumor, has a 6.8% survival rate 5 years post diagnosis. Our team developed an oncolytic adenovirus with an OX-40L expression cassette named Delta-24-RGDOX. While studies have revealed the interaction between the gut microbiota and immunotherapy agents, there are no studies linking the gut microbiota with viroimmunotherapy efficacy. We hypothesize that gut bacterial signatures will be associated with oncolytic viral therapy efficacy. To test this hypothesis, we evaluated the changes in gut microbiota in two mouse cohorts: (1) GSC-005 glioblastoma-bearing mice treated orally with indoximod, an immunotherapeutic agent, or with Delta-24-RGDOX by intratumoral injection and …

Comprehensive Quality Assessment For Aphasia Rehabilitation After Stroke: Protocol For A Multicentre, Mixed-Methods Study, Sam Harvey, Marissa Stone, Sally Zingelman, David A. Copland, Monique F. Kilkenny, Erin Godecke, Dominique A. Cadilhac, Joosup Kim, Muideen T. Olaiya, Miranda L. Rose, Caterina Breitenstein, Kirstine Shrubsole, Robyn O'Halloran, Annie J. Hill, Deborah Hersh, Kathryn Mainstone, Penelope Mainstone, Carolyn A. Unsworth, Emily Brogan, Kylie J. Short, Clare L. Burns, Caroline Baker, Sarah J. Wallace

Research outputs 2022 to 2026

INTRODUCTION: People with aphasia following stroke experience disproportionally poor outcomes, yet there is no comprehensive approach to measuring the quality of aphasia services. The Meaningful Evaluation of Aphasia SeRvicES (MEASuRES) minimum dataset was developed in partnership with people with lived experience of aphasia, clinicians and researchers to address this gap. It comprises sociodemographic characteristics, quality indicators, treatment descriptors and outcome measurement instruments. We present a protocol to pilot the MEASuRES minimum dataset in clinical practice, describe the factors that hinder or support implementation and determine meaningful thresholds of clinical change for core outcome measurement instruments. METHODS AND ANALYSIS: This research …

2024-03-21 Faculty Senate Meeting Minutes, Morehead State University. Faculty Senate.

Faculty Senate Records

Faculty Senate meeting minutes from March 21, 2024.

Trauma In Anesthesiology, Daniela Ferrer Gonzalez, Konstantin Inozemtsev

Advocate GME

No abstract provided.

Mapping Sca1 Regional Vulnerabilities Reveals Neural And Skeletal Muscle Contributions To Disease, Lisa Duvick, W Michael Southern, Kellie A Benzow, Zoe N Burch, Hillary P Handler, Jason S Mitchell, Hannah Kuivinen, Udaya Gadiparthi, Praseuth Yang, Alyssa Soles, Carrie A Sheeler, Orion Rainwater, Shannah Serres, Erin B Lind, Tessa Nichols-Meade, Yun You, Brennon O'Callaghan, Huda Y Zoghbi, Marija Cvetanovic, Vanessa C Wheeler, James M Ervasti, Michael D Koob, Harry T Orr

Duncan NRI Faculty and Staff Publications

Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused by an expanded polyglutamine tract in the widely expressed ataxin-1 (ATXN1) protein. To elucidate anatomical regions and cell types that underlie mutant ATXN1-induced disease phenotypes, we developed a floxed conditional knockin mouse (f-ATXN1146Q/2Q) with mouse Atxn1 coding exons replaced by human ATXN1 exons encoding 146 glutamines. f-ATXN1146Q/2Q mice manifested SCA1-like phenotypes including motor and cognitive deficits, wasting, and decreased survival. Central nervous system (CNS) contributions to disease were revealed using f-ATXN1146Q/2Q;Nestin-Cre mice, which showed improved rotarod, open field, and Barnes maze performance by 6-12 weeks of age. In contrast, …

Design To Data For Mutants Of Β-Glucosidase B From Paenibacillus Polymyxa: E26k, I170y, And V398n, Carter Ahlstedt, Annika Bennett, Daniel Kaluka

Lux et Fides: A Journal for Undergraduate Christian Scholars

Protein modeling aids in developing novel protein configurations that are critical in, for example, the pharmaceutical and environmental industries. However, the predictive capabilities of the protein modeling algorithms are limited due to a lack of experimental data on structure and function. To bridge this gap, Seigel Lab at UC Davis developed the Design to Data (D2D) program to catalog thermal stability and catalytic efficiency data sets on β-glucosidase B (BglB) variants. Over 300 BglB variants have been characterized. However, there are over 8400 possible BglB single-point mutations. We utilized Foldit software to design BglB mutants E26K, I170Y, and V398N. The …

Answering The Call From Victims Of Dating Violence: Georgia’S New Dating Violence Law, Sydney K. Parish

Georgia Criminal Law Review

Dating violence is a topic that has garnered increased awareness in recent days, both in the media and in the legal field. Many states have begun to pass legislation in attempt to address this issue and provide relief for victims of dating violence. In the summer of 2021, the state of Georgia passed House Bill 231, what later became known as Georgia’s Dating Violence law. This Article first examines our nation’s history of intimate partner violence to show why dating violence legislation was so desperately needed and how these legislative reforms have attempted to heal a system that for so …

The Death Dignity Demands: The Eighth Amendment Requires Incarcerated People Decide Their Method Of Execution, Kali A. Haney

Georgia Criminal Law Review

Recently, there have been a number of incarcerated people on death-row challenging their method of execution and proposing an alternative: usually, firing squad. Courts are hesitant to grant this request for a number of reasons, including the rare use of the firing squad. But there is substantial evidence this method is the most humane. Additionally, it appears incarcerated people think so, which is why so many in recent years chose—or petitioned for—death by firing squad rather than lethal injection or electrocution. As pharmaceutical companies halt their drugs’ distribution to prisons, prisons are forced to come up with their own—often more …

Protecting Our Nation’S Children In The Technological Age: Arguing For An Interpretation Of “Sexual Activity” In 18 U.S.C. § 2422(B) That Does Not Require Physical Contact, Allison Fine

Georgia Criminal Law Review

Our Nation’s justice system values “equal protection under the law.” This represents the belief that all individuals should be treated equally under the law regardless of personal characteristics. Traditionally, we think about this in a context of things like race, gender, or ethnicity. However, this also encompasses the general idea that individuals nationwide should be accountable to and protected by the same laws. As it relates to criminal law, this notion highlights the importance of uniformity in a criminal justice system. Without consistent application and execution, a criminal justice system will never be fair or “equal.”

The federal child enticement …

Purpose’S Purposes: Culpability, Liberty, Legal Wrongs, And Accomplice Mens Rea, Kevin Cole

Georgia Criminal Law Review

The federal mens rea for accomplice liability—important in its own right and also as an example to the states—is unsettled. Three cases from the just completed Supreme Court term hint (somewhat surprisingly) at various directions the justices might take. This essay examines the cases with a particular focus on the alternative explanations that might be given for the traditional requirement of purposeful facilitation for accomplice liability. The purpose requirement is contestable so long as it is justified in terms of a narrow conception of culpability. It is better understood as serving a liberty-enhancing function. The liberty focus clarifies difficult questions …

Hybrid Sparse-Dense Embedding Search, Eric Stavarache, Felix Weissenberger

Defensive Publications Series

This disclosure describes techniques of information retrieval from text-based corpuses by combining dense and sparse embeddings into a single, composite, dense embedding. Documents from the corpus most relevant to a user query can be found by using the composite dense embedding to natively run nearest-neighbor searches using existing tools. The techniques retain information from both sparse and dense embeddings and provide a straightforward, mathematically sound way of combining them. The composite dense embedding, when used in retrieving information in response to a user query, performs well even when the query includes a proper name or a rare term, and can …

Benefits Of Pilates Exercises On Functional Fitness And Quality Of Life In Older Men: A Quasi-Experimental Study, Mohammad Khazaei, Jolanta Marszałek, Reza Aminzadeh, Elham Dehghani, Bahador Azizi

Baltic Journal of Health and Physical Activity

Introduction: As age increases, declines in basic motor skills are observed in older men. Limited physical activity-based interventions, such as Pilates exercises, focus on enhancing these basic motor skills. This study aimed to identify the benefits of Pilates exercises on functional fitness and the quality of life in older men.

Material and Methods: Older men were randomly assigned to either a Pilates exercises group or a control group. Balance, strength, flexibility, and agility were tested using the Senior Fitness Test (SFT). The Quality-of-Life Questionnaire (SF-36) assessed the quality of life before and after 6 weeks of Pilates exercises. Differences over …

Rejoinder To Rural Transformations And Rural Crime Book Review Published In Rural Society (Vol. 32, Iss. 3), Matt Bowden, Alistair Harkness

Articles

In his review, John Scott makes two key but misleading charges: first is an intimation that rural criminology is dominated by a clique of scholars; and second that the book by and large lacks ‘critical’ analysis to his liking. The reviewer provides a glimpse of a broad analysis of the field and adopts an independently minded position. Indeed, some observations and claims are made that should rightly be part of a wider debate in criminology broadly, about its relevance, impact and contribution to the social sciences: legitimate and important questions that ought to be addressed. However, a few errors in …

Spartan Daily, March 20, 2024, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2024

Volume 162, Issue 24

Considerations For The Use Of Porcine Organ Donation Models In Preclinical Organ Donor Intervention Research, Frazer I. Heinis, Shaheed Merani, Nicholas W. Markin, Kim F. Duncan, Michael J. Moulton, Lance Fristoe, William E. Thorell, Raechel A. Sherrick, Tami R. Wells, Matthew T. Andrews, Marian Urban

School of Natural Resources: Faculty Publications

Use of animal models in preclinical transplant research is essential to the optimization of human allografts for clinical transplantation. Animal models of organ donation and preservation help to advance and improve technical elements of solid organ recovery and facilitate research of ischemia–reperfusion injury, organ preservation strategies, and future donor-based interventions. Important considerations include cost, public opinion regarding the conduct of animal research, translational value, and relevance of the animal model for clinical practice. We present an overview of two porcine models of organ donation: donation following brain death (DBD) and donation following circulatory death (DCD). The cardiovascular anatomy and physiology …

Divergent Detection: A Comprehensive Study Of Dgas Using Fnns For Original, Noise-Modified, And Linear Recursive Sequences(Lrs), Anthony Rizi

Masters Theses & Doctoral Dissertations

This comprehensive research endeavors to address a pressing issue within the realm of cybersecurity—the challenge posed by malicious activities utilizing Domain Generation Algorithms (DGAs). These algorithms, numbering at least 84 traditional malware families as of late 2023, dynamically generate domain names to facilitate nefarious operations while evading conventional detection mechanisms. The study generated over 159,750 domains and studied more than 1.27 million data points. Existing studies have predominantly focused on surface-level aspects of DGAs, including domain lengths, alphanumeric values, and top-level domains (TLDs). In response to this challenge, the research question at the core of this study aims to investigate …

Expression Of Als-Pfn1 Impairs Vesicular Degradation In Ipsc-Derived Microglia., Salome Funes, Jonathan Jung, Del Hayden Gadd, Michelle Mosqueda, Jianjun Zhong, Shankaracharya, Matthew Unger, Karly Stallworth, Debra Cameron, Melissa S Rotunno, Pepper Dawes, Megan Fowler-Magaw, Pamela J Keagle, Justin A Mcdonough, Sivakumar Boopathy, Miguel Sena-Esteves, Jeffrey A Nickerson, Cathleen Lutz, William C Skarnes, Elaine T Lim, Dorothy P Schafer, Francesca Massi, John E Landers, Daryl A Bosco

Faculty Research 2024

Microglia play a pivotal role in neurodegenerative disease pathogenesis, but the mechanisms underlying microglia dysfunction and toxicity remain to be elucidated. To investigate the effect of neurodegenerative disease-linked genes on the intrinsic properties of microglia, we studied microglia-like cells derived from human induced pluripotent stem cells (iPSCs), termed iMGs, harboring mutations in profilin-1 (PFN1) that are causative for amyotrophic lateral sclerosis (ALS). ALS-PFN1 iMGs exhibited evidence of lipid dysmetabolism, autophagy dysregulation and deficient phagocytosis, a canonical microglia function. Mutant PFN1 also displayed enhanced binding affinity for PI3P, a critical signaling molecule involved in autophagic and endocytic processing. Our cumulative data …

Back In The Ring: A Survey Of The Communist Party Of The United States: 1956-1976, Zachary Carlson

Theses and Dissertations

The Communist Party of the United States (CPUSA) suffered greatly under McCarthyism and by 1956 was no longer considered a viable political party by contemporary historians. Therefore, contemporary historians ignore the efforts of the CPUSA after this date. Failure to engage with the CPUSA post 1956 ignores their activity and contribution to the political and social landscape of the United States during the New Left, Civil Rights Movement, and Anti-War Movement. The CPUSA remained an influential political party and organizing power during the post-McCarty years. This survey exemplifies the methods used and spaces occupied by the CPUSA that allowed them …

Usa V. Kenneth Blakeney

2024 Decisions

USDC for the Eastern District of Pennsylvania

59th Student Senate Week 7 Meeting Minutes, Zoe Joubert

Student Senate Meeting Minutes

No abstract provided.

Potential Metabolite Biomarkers Of Multiple Sclerosis From Multiple Biofluids, Fatema Bhinderwala, Heidi E. Roth, Mary Filipi, Samantha Jack, Robert Powers

Robert Powers Publications

Multiple sclerosis (MS) is a chronic and progressive neurological disorder without a cure, but early intervention can slow disease progression and improve the quality of life for MS patients. Obtaining an accurate diagnosis for MS is an arduous and error-prone task that requires a combination of a detailed medical history, a comprehensive neurological exam, clinical tests such as magnetic resonance imaging, and the exclusion of other possible diseases. A simple and definitive biofluid test for MS does not exist but is highly desirable. To address this need, we have employed NMR-based metabolomics to identify potentially unique metabolite biomarkers of MS …

Minutes From March 20 2024, University Senate

University Senate Minutes

Minutes from March 20 2024 University Senate Meeting