Tmem106b Coding Variant Is Protective And Deletion Detrimental In A Mouse Model Of Tauopathy, George A Edwards, Caleb A Wood, Yang He, Quynh Nguyen, Peter J Kim, Ruben Gomez-Gutierrez, Kyung-Won Park, Yong Xu, Cody Zurhellen, Ismael Al-Ramahi, Joanna L Jankowsky

Duncan NRI Faculty and Staff Publications

TMEM106B is a risk modifier of multiple neurological conditions, where a single coding variant and multiple non-coding SNPs influence the balance between susceptibility and resilience. Two key questions that emerge from past work are whether the lone T185S coding variant contributes to protection, and if the presence of TMEM106B is helpful or harmful in the context of disease. Here, we address both questions while expanding the scope of TMEM106B study from TDP-43 to models of tauopathy. We generated knockout mice with constitutive deletion of TMEM106B, alongside knock-in mice encoding the T186S knock-in mutation (equivalent to the human T185S variant), and …

Advocacy Connection Team-Now Educational Program For Headache Fellows And Patients/Caregivers: Assessment Of Educational Objectives, Courtney Seebadri-White, Hsiangkuo Yuan, William B. Young, Karissa N. Arca

Department of Neurology Faculty Papers

OBJECTIVE: To assess for improvement in comfort in participating in advocacy for migraine and headache disorders and knowledge needed for successful advocacy.

BACKGROUND: The Advocacy Connection Team (ACT)-Now program is an educational program offered through Miles for Migraine, a non-profit advocacy organization. It is designed to teach headache fellows and patients advocacy skills.

METHODS: In a cross-sectional pre-test-post-test design, the 2021 ACT-Now cohort of 98 participants were administered a set of 11 pre-course survey questions identifying their role (healthcare provider/headache fellow or patient/caregiver), baseline knowledge of migraine-related disability and stigma, and baseline engagement and comfort with advocating. The post-course survey …

Patterns Of Social Responsibility Among Gifted Students And Their Relationship To Certain Variables, Suhair Al-Tal, Fuad Al-Jawaldeh, Heyam Al-Taj, Wafaa Al-Eid

Jordan Journal of Applied Science-Humanities Series

The current study aimed to identify the degree of prevalence of social responsibility patterns among gifted students in schools in Cairo during the second semester of the academic year 2019/2020. The study sample consisted of 196 male and female students from grades eight and ten, all of whom achieved an average of 90% or higher. The sample included 102 female students and 94 male students. The researchers developed and applied a social responsibility scale encompassing three patterns: self, family, and social, after verifying its validity and reliability. The results indicated that the prevalence of social responsibility patterns among gifted students …

Developmental Differences In Reported Speech And Internal State Language In Preschoolers’ Personal Narratives, Megan E. Welliver, Alice J. Davidson, Alexandra Mccrary

Faculty Publications

The present study explored developmental differences in preschoolers’ use of reported speech and internal state language in personal narratives. Three-, four-, and five-year-olds attending a laboratory preschool shared 204 stories about ‘a time when you were happy/sad’. Stories were audio-recorded, transcribed, and coded for reported speech (direct, indirect, narrativized) and internal state language (cognitive states, total emotion terms, unique emotion terms). Personal narratives told by five-year-olds included more cognitive states and more narrativized speech than those told by three- and four-year-olds, even when accounting for children’s vocabulary skills, and that reported speech (narrativized, direct) were positively correlated with cognitive state …

The Chronicle, Kennedy Ballinger, Lara Jones, Dashae Engler, Bella Perez, Emily Riley, Riley Dickerson, Maya Pierce, Andy Langager

Campus Chronicle

No abstract provided.

Ohio’S Failure To Protect Motorcyclists' Heads: A Law Enforcement Perspective, B. Thomas

Et Cetera

As a former police officer, the aftereffects of helmetless motorcycle crashes will forever haunt me. This Article discusses the need for helmet laws for all motorcyclists.

Inequitable By Design: The Strategic Distribution Of Costs And Benefits By Business Improvement Districts And Special Assessments, Molly Gillespie

Et Cetera

Business Improvement Districts (BIDs) are most commonly credited for their innovative strategies in rejuvenating the economic vitality in American cities. However, their implementation raises concerns about fairness and equity. The current practice of financing BIDs through special assessments, particularly applying the front footage method, disproportionately burdens certain property owners for the benefit of others. Consequently, property owners face a range of issues, including financial strain, involuntary annexation, and potential threats to property ownership. However, the existing framework of state constitutions lack the necessary provisions to adequately address these challenges, underscoring the need for significant reform.

This Note addresses these concerns …

The Invasive Bank Vole (Clethrionomys Glareolus); A Longitudinal Investigation Into Rodents And Their Pathogen Communities, Using The Irish Rodent Invasion As A Model System., Andrew Mcmanus

Theses

The recent emergence of zoonotic pathogens such as, SARS-CoV-2, Ebola and Mpox, have emphasised the necessity to study wildlife and their pathogens. A knowledge gap currently exists in longitudinal studies of biological invasions, which are needed to understand the change in pathogen communities caused as the invader becomes more established. The invasion of Clethrionomys glareolus in Ireland provides a unique model system to study these changes at different stages of the bio-invasion. This is due to the depauperate small mammal community in Ireland, identifiable source population, introduction point, and ongoing expansion of C. glareolus in Ireland. Extensive work has been …

Digital Safe Spaces: Nonbinary Community Building On Tiktok, Xan Daggett

Theses and Dissertations

Queer and trans individuals have long relied on the Internet for community building and support; however, with the introduction of more than 700 anti-trans bills since the beginning of 2023 (Trans Legislation Tracker, 2024), conservatives’ consistent mocking and dehumanization of gender nonconforming people (ADL, 2023; Berg-Brousseau, 2022), and a record increase in violence specifically against nonbinary individuals (Astor, 2023), trans and nonbinary people are turning to online spaces more than ever as they endure this hostile social and political climate. While nonbinary people make up over 60% of trans adults in the U.S. (Kirzinger et al., 2023), there is very …

The Shock Cone Instabilities And Quasi-Periodic Oscillations Around The Hartle–Thorne Black Hole, Orhan Donmez, Fatih Dogan

Materials Science and Engineering Faculty Research & Creative Works

To explain the observed X-ray data in a black hole–accreting matter system and understand the physical mechanisms behind QPOs, we have numerically modeled the dynamical and oscillation properties of the shock cone formed around both slowly and rapidly rotating Hartle–Thorne black holes, resulting from the mechanism of Bondi–Hoyle–Lyttleton (BHL). According to the numerical simulations, an increase in the quadrupole parameter leads to a decrease in the shock cone opening angle around the black hole. A larger quadrupole parameter results in more matter falling into the black hole within the cone. The combination of the quadrupole parameter and black hole rotation …

Lawful Injustice: Novel Readings Of Racialized Temporality And Legal Instabilities, Danielle N. Mercier

USF Tampa Graduate Theses and Dissertations

This project, “Lawful Injustice: Novel Readings of Racialized Temporality and Legal Instabilities,” examines three specific BIPOC communities across literature—Native American, African American, and Asian American—to understand the influence of U.S. legal frameworks and temporalities upon both the collective and the individual. I assess how legal frameworks create and protect their own instabilities as well as understand how they are produced by the uneven temporal structures of the law. I examine how such legal and settler colonial temporalities are at odds with Native American, African American, and Asian American temporalities. These temporalities—a legal/juridical temporality which reinscribes settler colonial oppression and the …

[Discussions] Vol. 19 Iss. 1

Discussions

This issue of Discussions was published for the Spring 2023 cycle.

Review Of The Safety And Efficacy Of Trauma-Focused Treatment Among Patients With Psychosis, Mary Eggers

Discussions

Among people who experience psychosis, many have comorbid post traumatic stress disorder (PTSD) that is frequently undiagnosed and untreated. Symptoms have long-term implications, such as hallucinations, posttraumatic intrusions, and an increased risk of physical health conditions, like heart disease and respiratory issues. Many clinicians believe that diagnosing and treating PTSD in this population will be dangerous, so these patients are often excluded from trauma-focused treatment based on their psychosis symptoms. This paper will review current data regarding the rates of undiagnosed PTSD among this population as well as the safety and efficacy of treatment options. PubMed was used to identify …

Stress Hormone And Heart Rate Responses To Various Exercise Training Methods, Tomas Gomez Jr., Rebekah Schlatter, Megan Zamora, Marco Arriago, Sue Anne Chew, Murat Karabulut

Research Symposium

Background: Blood Flow Resistance (BFR) training has garnered attention for its ability to induce positive physiological adaptations with low-load resistance exercise. The present study aimed to examine the responses of catabolic hormones and heart rates (HR) to various BFR training protocols. This investigation seeks to provide insights into the stress levels induced by different protocols and identification behind the most effective protocol for optimal positive exercise-related adaptations.

Methods: Study population involved 10 healthy adult males (height: 175.0±5.0 cm, weight: 96.67±26.6 kg, age: 21.3±2.67 yr.) in a five-session investigation. Informed consent paperwork, pre-testing and anthropometric measurements served as session 1; sessions …

Spontaneous Tumor Lysis Syndrome In A Patient With Recent Diagnosis Of Multiple Myeloma — An Unusual Presentation, Taha Al Hassan, Olga G. Cantu-Rodriguez, Eunbee Cho, Edgar G. Dorsey Trevino

Research Symposium

Background: Tumor lysis syndrome (TLS) is an oncologic emergency that surfaces as a constellation of metabolic imbalances due to the rapid destruction of cancer cells and subsequent dissemination of their contents. However, a markedly rare subtype of TLS, known as spontaneous TLS (STLS), occurs without an evident trigger, such as cytotoxic therapy, and carries a similar mortality risk. It is paramount to recognize high-risk cases early and implement therapeutic measures to prevent complications of STLS.

Case Presentation: We present the case of a 74-year-old gentleman with a recent diagnosis of Kappa-restricted multiple myeloma who presented with worsening weakness, tremors, ataxia, …

From Shield To Sword: Straying From The Original Meaning Of The Establishment Clause, Tavia Bruxellas Mcalister

Nebraska Law Bulletin (Selected Issues)

Clause jurisprudence has strayed far from its original roots, leaving a string of nonsensical decisions, on every topic, in its wake. Kennedy v. Bremerton School District can serve as the North Star, guiding courts back to a consistent standard of history and tradition, but it alone will not be sufficient. Courts should return to the original force and funds view of the framers by making actual legal coercion the cornerstone of Establishment Clause standards. This clear-cut standard would save the courts from subjectivity and help heal the fractured precedent, leaving room for reasonable and consistent application. If the Court returned …

Participation Mandatory, Learning Not Required: A Phenomenological Study Of Diversity Training In Education And Law Enforcement, Jamie Martin, Tabari Asim Coleman, Toni J. Fall, Crystal L. Isom, Jennifer L. Niebrzydoski

Dissertations

This study provides a timely, qualitative exploration of the perceived efficacy of cultural competency training for both law enforcement officers and educators. It comprises 18 semi-structured interviews, 10 of which were conducted with education professionals and 8 with law enforcement officers. Drawing four main themes from the interview sample, findings show participants held a complex perception of training efficacy. Interviews featured multiple anecdotes from participants concerning the application of culturally competency skills, as well as important takeaways concerning their desired topics/format of professional development sessions and their favored characteristics of facilitator approach. Our analysis further reveals implications of participants’ identity …

For Black Women - When The Rainbow Was Not Enough (Shange, 1976, New York City): An Autoethnographic Collection About Spirit Assassination, Teresa Quarles, Tamika Galvin, Sherrie Mcclellan

Dissertations

ABSTRACT

We live in an America where the higher you elevate in your career as a Black woman, the greater your chances of being subjected to racism, discrimination, isolation, and bullying. We are underrepresented in various elevated roles, but we will not let that stop us. As Black women, we can attest to the experiences that we are subjected to with no question about our mental health. The Black community in America has been subjected to a considerable presence of systemic racism, oppression, and violence - with the objectives of exercising authority and oppressing the Black community, as well as …

Ethnic Studies And White Identity, Aimee Snelling, Kara Cisco

Dissertations

Abstract

This dissertation addresses white individuals’ experiences in ethnic studies courses and addresses concerns that there is too little research in this area. Drawing on the theoretical frameworks of Critical Whiteness Studies and Interpretive Phenomenological Analysis, this qualitative research study examines the lived experiences of white individuals who have taken at least one ethnic studies course in high school and explores the extent to which these experiences influence the development of their racial identity in the present. An extensive literature review includes the most recent research on Critical Whiteness Studies, white racial identity development, ethnic studies, and Interpretive Phenomenological Analysis. …

Constitutional Property And Progressive Property’S Compatibility: A Reappraisal, Rachael Walsh

Texas A&M Journal of Property Law

Progressive property theory is driven by a desire to improve the law, and legal outcomes, for those on the margins of society. At the same time, it largely assumes the compatibility of constitutional property rights with its aims. However, constitutional property doctrine is often ambiguous on the core question of what distribution of collective burdens is susceptible to invalidation. Such ambiguity in turn can support political over-inflation of the strength of constitutional protection for property rights. Given the resulting chilling effect that constitutional property rights can have on measures that interfere with property rights, the Article argues that progressive property …

Operationalising Progressive Ideas About Property: Resilient Property, Scale, And Systemic Compromise, Lorna Fox O'Mahony, Marc Roark

Texas A&M Journal of Property Law

Property theory is at a crossroads. In recent decades, scholars seeking to advance progressive ideas about property have embraced ‘Progressive Property’ theories that seek to advance the goals of social justice and the common good, offering a vital counter-weight to utilitarian and neo-conservative accounts of property. Progressive Property theories seek to correct an imbalance in American property discourse which—across the temporal scale—has sustained a range of narratives and normative commitments, but which has veered towards extreme acquisitive individualism and the rhetoric of property absolutism since the 1970s. The idea that individual property rights are not absolute but defined by the …

Juvenile Delinquency As A Contemporary Issue In Nigeria: Understanding The Impacts Of Parenting Styles, Single Parenting, And Marital Discord, Sunkanmi Folorunsho, Oluwakemi Abdulrazaq, Victor Ajayi

Department of Sociology: Dissertations, Theses, and Student Research

When addressing juvenile delinquencies in Nigeria, it is important to consider the roles and effects of parenting styles and family structures. Although, there are no universally accepted parenting styles, evidence and studies have pointed to some parenting styles that expose children to delinquent behaviors. We examined different parenting styles comprehensively in this article and how these styles can influence juvenile delinquencies. We also discussed the association between single-parenting and behavioral outcomes; accounting how single-parenting may increase risks of delinquencies. Furthermore, marital discord was discussed and social learning theory by Albert Bandura was adopted to buttress our positions. We concluded that …

The Effect Of Covid-19 Infection On Clinical Outcomes In Patients Undergoing Surgical Repair Of Humerus Fractures, Nicholas Scigliano, Troy B. Puga, Noah M. Scigliano, Yale K. Williams, Michael A. Boin

Student Publications

Introduction

Limited research exists on the association between coronavirus 2019 (COVID-19) infection and outcomes following surgical fixation for humerus fractures. The objective of this study was to evaluate the effects of COVID-19 on the clinical outcomes of patients undergoing humerus fracture surgery.

Methods

Approval to utilize insurance claim data from the Change Healthcare dataset was obtained from the Datavant COVID-19 Research Database. Patients older than 55 years old who underwent humerus fracture surgery from April 1, 2020, to March 1, 2022, were included in the analysis. COVID-19 status, comorbidities, and adverse events were identified using the International Classification of Diseases, …

Prostate Cancer Survivorship Essentials For Men With Prostate Cancer On Androgen Deprivation Therapy: Protocol For A Randomised Controlled Trial Of A Tele-Based Nurse-Led Survivorship Care Intervention (Pcessentials Hormone Therapy Study), Anna Green, Robert U. Newton, David P. Smith, Haitham Tuffaha, Daniel A. Galvão, Peter Heathcote, Manish I. Patel, David Christie, Sam Egger, Sally A. M. Sara, Nicole Heneka, Suzanne K. Chambers, Jeff Dunn

Research outputs 2022 to 2026

Introduction: Androgen deprivation therapy (ADT) is commonly used to treat men with locally advanced or metastatic prostate cancer. Men receiving ADT experience numerous side effects and frequently report unmet supportive care needs. An essential part of quality cancer care is survivorship care. To date, an optimal effective approach to survivorship care for men with prostate cancer on ADT has not been described. This protocol describes a randomised trial of tele-based nurse-led survivorship that addresses this knowledge gap: (1) determine the effectiveness of a nurse-led survivorship care intervention (PCEssentials), relative to usual care, for improving health-related quality of life (HR-QoL) in …

Alyosha The Christian Hermeneut, Eddie Li

Seaver College Research And Scholarly Achievement Symposium

Presentation Abstract: Alyosha as the Christian Hermeneut

This presentation is adapted from my essay Alyosha as the Christian Hermeneut, written under the supervision of Dr. Paul Contino. In the essay, I gave an analysis of the character Alyosha in Dostoyevsky’s The Brothers Karamazov, in light of Merleau-Ponty’s phenomenology, Hans-Georg Gadamer’s hermeneutics, and Dr. Contino’s book on Incarnational Realism. I discussed how Alyosha adapts from an inexperienced Christian disciple to a mature interpreter capable of conducting the hermeneutical fusion of horizons with different horizons. Within this capability, Alyosha develops his unique Christian horizon, enabling him to understand and reconcile the …

Session Ic: Education And Psychology Presentation 1 - A Closer Look At Stephen Krashen’S Language Theories In The 21st Century, Paula Harvie

Life of the Scholar Multidisciplinary Conference

No abstract provided.

Machine Learning Prediction Of Photoluminescence In Mos2: Challenges In Data Acquisition And A Solution Via Improved Crystal Synthesis, Ethan Swonger, John Mann, Jared Horstmann, Daniel Yang

Seaver College Research And Scholarly Achievement Symposium

Transition metal dichalcogenides (TMDCs) like molybdenum disulfide (MoS2) possess unique electronic and optical properties, making them promising materials for nanotechnology. Photoluminescence (PL) is a key indicator of MoS2 crystal quality. This study aimed to develop a machine-learning model capable of predicting the peak PL wavelength of single MoS2 crystals based on micrograph analysis. Our limited ability to consistently synthesize high-quality MoS2 crystals hampered our ability to create a large set of training data. The project focus shifted towards improving MoS2 crystal synthesis to generate improved training data. We implemented a novel approach utilizing low-pressure chemical vapor deposition (LPCVD) combined with …

Effectiveness Of Frog Skin Secretions Against Uv-B Radiation, Connor Mcgaha, Kinkade Mcmurray, Lee B. Kats

Seaver College Research And Scholarly Achievement Symposium

As an increasing number of their species face possible extinction, amphibian populations have been steadily declining over the past decades (IUCN). While various factors have been suggested or proven to be partially responsible for this reduction, increased ultraviolet B radiation (UVBR) appears to be one of the more prominent explanations, especially when considering the continual thinning of the Earth’s ozone layer due to anthropogenic climate change. However, it has also been discovered that skin secretions, which are reported to function as a component of amphibians’ innate immune systems, may have an effect on UVBR (Cramp and Franklin). With this in …

Idiopathic And Neuromuscular Scoliosis In A Female College Basketball Player Requiring Spinal Correction Surgery, Magan Kim

UNO Student Research and Creative Activity Fair

The purpose of this report is to present the case of a 20-year-old female collegiate basketball player who was diagnosed with a combination of idiopathic and neuromuscular scoliosis. Patient underwent thoracic spinal fusion surgery when she was 15 to resolve her extreme scoliosis. The uniqueness of this case stems from the athlete’s urgency to have to undergo a life-altering spine operation and still be able to successfully contribute to a collegiate basketball team. Athletic trainers should be knowledgeable and aware of how to maintain treatment/rehabilitation for athletes with scoliosis, operative or non-operative. Scoliosis should no longer be a reason to …

Little Bit About Liddle: Big Improvement In Blood Pressure, Shreel Patel, Roy Kondapavuluru, Eunbee Cho, Fatimah Bello, Jian Garcia Cruz

Research Symposium

Background: Liddle syndrome is a rare autosomal dominant disorder associated with abnormalities in function of the collecting tubule sodium channel, also called the epithelial sodium channel (ENaC). ENaC function is increased in the Liddle’s syndrome leading to the manifestations of mineralocorticoid excess symptoms, such as hypertension, hypokalemia, and metabolic alkalosis. The diagnosis is made when these features are seen with low renin and low plasma or urinary aldosterone. Genetic testing is not required for the diagnosis of Liddle syndrome. Liddle's syndrome has an excellent response to amiloride.

Case Presentation: A 56-year-old gentleman, with longstanding uncontrolled hypertension was seen for functional …