Digital Commons Network^™

Kinase Suppressor Of Ras 2 Regulates Energy Balance And Tumor Initiation, Dianna H. Huisman

Theses & Dissertations

Kinase Suppressor of Ras 2 (KSR2) is a scaffold that facilitates Raf-MEK-ERK signaling and is expressed in the brain, pituitary, and adrenal gland. Here, we demonstrate that KSR2 functions in the adult brain to maintain organismal energy balance and in small-cell lung carcinoma (SCLC) to promote self-renewal and clonogenicity. Disruption of KSR2 in adult mice results in hyperphagia, obesity, reduced metabolic rate, and altered activity. Using spatial transcriptomics, we identify regions of the brain associated with regulation of feeding and energy expenditure with altered gene expression following KSR2 disruption. These findings reveal regions of interest in which targeted KSR2 disruption …

Claudin-1-Mediated Signaling And Therapy Resistance In Colorectal Cancer: From Mechanism To Translation, Mark W. Primeaux

Theses & Dissertations

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality, with metastatic cases showing poor response to chemotherapy due to both intrinsic and acquired therapy resistance. Claudin-1 (CLDN1), a tight junction protein, is overexpressed and mislocalized outside of tight junctions in CRC, where it contributes to an aggressive, metastatic phenotype. Although this causal relationship has been well established, the mechanisms by which CLDN1 promotes tumor progression were unclear due to its lack of intrinsic enzymatic activity. This dissertation investigates the molecular mechanisms through which CLDN1 drives oncogenic signaling, its role in therapy resistance, and its translational potential as both a …

Beyond The Bruise: Understanding Injury Risk Factors Among Livestock Workers In Cattle Feedyards And Animal Handling Farms And Ranches, Rishad Ahmed

Theses & Dissertations

Cattle feeding and livestock production are central to U.S. agriculture and represent some of the most hazardous occupational environments. Workers in feedyards and on cattle farms and ranches face elevated risks of injury due to physically demanding labor, frequent animal handling, and exposure to environmental and ergonomic hazards. Many feedyard workers are Hispanic/Latino immigrants who may experience additional barriers related to language, healthcare access, and job security. Similarly, injury risks among cattle producers are compounded by seasonal workload fluctuations, limited rest opportunities, and psychosocial stressors. Beyond individual impacts, agricultural injuries also pose a substantial economic burden. Recent estimates indicate that …

The Characterization Of Per- And Polyfluoroalkyl Substances (Pfas) In Nebraska Drinking Water And Human Health Impacts, Sarah Tucker

Theses & Dissertations

Per- and polyfluoroalkyl substances (PFAS) are synthetic compounds that have been detected in water sources of urban and rural environments with evidence of adverse human health effects from exposure. Humans are primarily exposed through ingestion of contaminated water and food. PFAS exposure has been linked to negative multi-system health outcomes (liver, kidneys, cardiovascular, reproductive, and immune). PFAS occur as persistent mixtures in environmental media with decades long consequences to water quality. While national agencies have launched large-scale PFAS water quality monitoring studies, limited data exists for contamination of rural water in Nebraska, especially private wells. The aims of this study …

A Replication And Extension Of The Enhanced Choice Model For Children Who Exhibit Challenging Behavior, Jessica Tran

Theses & Dissertations

Rajaraman et al. (2022) first introduced the Enhanced Choice Model (ECM) as an intervention that incorporates assent within the treatment framework. Shortly after, Staubitz et al. (2022) and Rajaraman et al. (2024) added to the literature available specifically regarding the ECM. Despite the initial successes of the ECM, it has only been applied to nine individuals. Of these, only two needed some form of modification to the treatment model. The criteria for these modifications was not specified within previous literature. Therefore, the purpose of the current study was twofold. First, we extended previous research by evaluating systematic modifications to the …

Learning Structure With Multivariate Information Bottleneck And Exploration Of New Methods In Sequential Decision Making, Volodymyr Makarenko

Master's Theses

Research in useful information extraction has been motivated by the increasing demand to extract insights from unstructured data, and by the need to store and transmit great volumes of information, often originating in unstructured data such as videos. Research in rate distortion and information bottleneck paved the path for understanding and guiding the design of lossy encoders, capable of extracting relevant information. Independently, research in deep representation learning has enabled numerous applications for unstructured high-dimensional data such as images. However, the interpretability of the deep learning methods remained limited. Several desired properties of learned representations have been suggested, including disentanglement. …

A Comparative Subnational Policy Analysis Of State Covid-19 Vaccine Policies And Application Of The Political Determinants Of Health Model, Demetrius Cianci Chapman

Nursing ETDs

A COMPARATIVE SUBNATIONAL POLICY ANALYSIS OF STATE COVID-19 VACCINE POLICIES AND APPLICATION OF THE POLITICAL DETERMINANTS OF HEALTH MODEL

By

Demetrius Cianci Chapman

Associate of Science Nursing, Jewish Hospital College of Nursing and Allied Health, 1998

Bachelor of Science of Nursing, Saint Louis University, 2000

Master of Public Health, Saint Louis University, 2004

Master of Science Nursing (Research), Saint Louis University, 2004

Doctor of Philosophy, Nursing, University of New Mexico, 2025

ABSTRACT

This study uses the political determinants of health (PDoH) framework to analyze state-level COVID-19 vaccine policies and their impact on population health. The PDoH model examines how structured …

Autonomous Uav Swarm Formation Utilizing Gradient-Driven Contour Mapping For Radiation Source Localization, Edgar Amalyan

UNLV Theses, Dissertations, Professional Papers, and Capstones

This thesis presents a drone swarm for radiation mapping to aid source localization. The Department of Energy advocates employing UAVs for this task, but existing approaches remain inefficient and impractical in real-world scenarios. Three custom drones are built and flight-tested. A control algorithm to follow a contour, a constant-intensity path, is designed using a gradient fit. By knowing the source’s direction, the drone swarm can fly in the optimal trajectory at every step, leaving nothing to assumption. A program is created that implements formation flight and autonomous navigation. It is tested via a software-in-the-loop simulation utilizing radiation sources and detectors …

Empowering Science With The World's First High Accuracy And High Throughput Functional Assay, Christopher Giacoletto

UNLV Theses, Dissertations, Professional Papers, and Capstones

Understanding the functional consequences of genetic mutations remains a central challenge in modern biology, with far-reaching implications for human health and disease. While early systematic methods like alanine scanning and phage display provided foundational insights into protein structure and function, the emergence of high-throughput approaches—such as Multiplexed Assays of Variant Effect (MAVEs)—and predictive tools powered by artificial intelligence have vastly expanded our ability to profile mutational landscapes. However, these methods are often constrained by trade-offs between accuracy, scalability, and biological relevance.This dissertation presents the development and application of the GigaAssay, the world’s first high-throughput functional assay capable of delivering both …

Exploring The Processing Of Objects, Settings, And Global Properties In Natural Auditory Scenes, Margaret A. Mcmullin

UNLV Theses, Dissertations, Professional Papers, and Capstones

Our auditory system has a remarkable ability to make sense of complex environments, allowing us to identify what we are hearing and where sounds come from. This process of auditory scene analysis is essential for situational awareness, decision-making, and effective communication in daily life. While much is known about how listeners segregate and identify individual sound sources (e.g., voices), less is understood about how global properties of a scene (e.g., openness, naturalness) contribute to perception. This dissertation examined how object- and setting-level information in natural auditory scenes are processed, and whether they rely on distinct or overlapping mechanisms. In Experiment …

The Dropbot: Design And Development Of A Custom Drone For Precision Water Drop Penetration Time (Wdpt) Testing, Mugundan Prakash

UNLV Theses, Dissertations, Professional Papers, and Capstones

Assessing the hydrophobic characteristics of soil is vital for understanding soil wettability or soil-water interactions, particularly in post-wildfire environments where water repellency can significantly impact ecosystem recovery, water infiltration, and erosion control. One key metric in soil wettability studies is the Water Drop Penetration Time (WDPT) test, which evaluates the hydrophobicity of soil and guides land treatment strategies. This thesis presents the design and development of DropBot, a custom-built drone platform engineered for the precise delivery and analysis of water droplets in WDPT tests.The DropBot, a custom drone, integrates a lightweight, 3D-printed frame with a self-leveling platform, enabling consistent droplet …

Internalized Weight Stigma As A Mediator Between Past Weight Stigma And Current Healthcare Avoidance/Comfort In Seeking Medical Care, Shannon Joyel Sagert

UNLV Theses, Dissertations, Professional Papers, and Capstones

Research has found that medical providers such as physicians, nurses, and medical support staff may contribute to externalized weight stigma directed toward youth (Garcia et al., 2016; Gorlick et al., 2021). Individuals who have encountered weight stigmatization may internalize those experiences, leading to psychological, physical, and behavioral changes that reduce their quality of life (Palad et al., 2019; Romano et al., 2023; Tanas et al., 2022; Zancu & Diaconu-Gherasim, 2023). However, little is known about how historical externalized weight stigma from medical providers relates to future healthcare access behaviors. This study examined whether internalized weight stigma mediated two relationships: First, …

Little Cigar And Cigarillo Graphic Health Warnings And Quitting Behaviors A Randomized Clinical Trial, Adam O. Goldstein, Kristen L. Jarman, Leah M. Ranney, Jennifer Cornacchione Ross, Sarah D. Kowitt, Chineme Enyioha, Sonia A. Clark, Paschal Sheeran, James F. Thrasher Ph.D., Ma, Ms, Desmond Jenson, Nadja A. Vielot

Faculty Publications

IMPORTANCE Although little cigars and cigarillos (LCCs) are common combustible tobacco products, the effects of LCC warning labels on behavioral outcomes remain untested.

OBJECTIVE To evaluate the effects of LCC graphic health warnings (GHWs) on promoting LCC quitting intentions and behaviors.

DESIGN, SETTING, AND PARTICIPANTS This randomized clinical trial included 1029 adult LCC users from a Qualtrics online panel who were randomized to (1) LCC GHWs (n = 339), (2) existing US Food and Drug Administration (FDA) text-only warnings (n = 346), or (3) no stimulus control (n = 344). Participants accessed messages via email from May 1 to August …

Msw Portfolio, Jennifer Lynn Barnhill

Graduate Student Portfolios, Professional Papers, and Capstone Projects

The Master of Social Work (MSW) Portfolio is a sample of the essays, presentations, projects, and experiences completed as part of my online MSW curriculum at the University of Montana (UM) School of Social Work (SSW) from 2022-2025. Throughout this narrative, I’ll describe the skills, values, theories, and frameworks I’ve learned during my three years working toward my master's degree in social work. Each of the appendices will demonstrate an understanding of the nine Council on Social Work Education, or CSWE, competencies (Texas College, n.d.) that all social workers are expected to meet, along with a tenth competency added by …

Msw Portfolio 2025, Lacie R. Ranieri

Graduate Student Portfolios, Professional Papers, and Capstone Projects

MSW Portfolio - 2025

Professional Portfolio, Grace E. Lowder

Graduate Student Portfolios, Professional Papers, and Capstone Projects

No abstract provided.

The Impact Of Alternatives To Incarceration And The Motherhood Identity On Mothers And Their Children: A Qualitative Study, Chloe Blau

Seton Hall University Dissertations and Theses (ETDs)

The U.S. prison system population increasingly includes women, a significant proportion of whom are mothers, often incarcerated for non-violent crimes. Some research suggests that alternative to incarceration (ATI) programs can help these women to continue supporting their children while serving their sentences and receiving services that may decrease recidivism. However, few studies have explored the lived experiences of women in these programs. This dissertation investigates the impact of participating in ATI programs on mothers and their relationship to their motherhood identity, their ability to mother, and their relationship with their children. Using a qualitative approach to better understand how women …

The Effectiveness Of Pre-Packaged Literacy Curriculum: A Document Analysis Of The Culturally Responsive Tenets In Pre-Packaged Literacy Curriculum, Grace Ghazzawi

Seton Hall University Dissertations and Theses (ETDs)

The introduction of the Common Core State Standards in 2010 sought to standardize educational expectations across the U.S., aiming to promote equity by ensuring all students received a high-quality education. However, educational disparities persist, particularly for historically marginalized students, leading to a continued achievement gap in literacy, especially among low-income students of color. While pre-packaged curricula have emerged as tools to align instruction with the rigor of the Common Core State Standards, their effectiveness in addressing the diverse needs of students from marginalized backgrounds remains uncertain. This study explores the intersection of pre-packaged literacy curricula and Culturally Responsive Teaching (CRT) …

The Influence Of Remote Instruction On Middle School Ell Students' New Jersey State Learning Assessment English Ela And Math Achievement, Marie Chezuette Dort

Seton Hall University Dissertations and Theses (ETDs)

This correlational study explained the influence of remote instruction on English Language Learner (ELL) students' middle school grades on the New Jersey Student Learning Assessment (NJSLA) achievement in English Language Arts (ELA) and Mathematics. This study focused on data collected in two separate school years and analyzed middle school grades with the ELL Subgroup. It indicated the correlation between remote instruction and ELL students' ELA and mathematical performance in the NJSLA Grades 6, 7, and 8. This study also included controlled variables, Grades 3, 4, and 5, from 2018-2019 and other student characteristics, the percentage of economically disadvantaged students and …

Sexual Intervention Self-Efficacy In Clinical And Counseling Psychology Doctoral Trainees: Examining Education, Family Sexual Communication, And Sex Positivity, Sara Aigen

Seton Hall University Dissertations and Theses (ETDs)

Sexual wellbeing is a critical yet often overlooked aspect of psychological health. Despite its significance, many psychologists report discomfort and low self-efficacy in addressing clients’ sexual concerns. The current study examined factors associated with sexual intervention self-efficacy among doctoral trainees in clinical and counseling psychology. Specifically, it investigated whether family communication about sex and didactic education in sexuality predicted sexual intervention self-efficacy and whether sex positivity moderated these relationships. A cross-sectional survey design was employed with 166 doctoral students enrolled in APA-accredited programs across the United States. Participants completed a demographic questionnaire and measures assessing family sexual communication, sex positivity, …

A Systematic Review To Assess The Use Of Peer Mediated Interventions For Children With Autism When Autistic Children Serve As Peer Instructors And Models, Corinne Boyce-Swem

Seton Hall University Dissertations and Theses (ETDs)

Abstract

Autism spectrum disorder is a neurodevelopmental disorder characterized by deficits in social communication, social interactions and restricted, repetitive and stereotyped patterns of behavior, interest or activities. These deficits hinder autistic children’s social and communicative skills. Peer-mediated interventions (PMIs) have been found effective in the development of communication, play and social skills in individuals with ASD. In PMIs typically developing children are trained to be peer models of socially acceptable behavior for children with ASD. This however may contrast with literature indicating that the most effective peer models are individuals who share similarities with the learner. The current study was …

Does The Literature Empirically Support The Use Of Behavior Analysis In The Treatment Of Sports Related Concussions: A Systemic Review, Kayla Mckoy

Seton Hall University Dissertations and Theses (ETDs)

Although the literature supports the use of applied behavior analytic (ABA) interventions in the treatment of traumatic and acquired brain injuries, the question remains as to whether or not ABA procedures are an effective treatment option specifically for TBI associated with sports related concussion (SRC). The purpose of the present study was to review the literature available on the use of ABA with individuals diagnosed with sport related TBI to determine if there is enough research to empirically support the use of behavior analysis in the treatment of sport related concussions. The PRISMA method for systematic reviews was used to …

The Effectiveness Of Kolmogorov–Arnold Networks In The Healthcare Domain, Vishnu S. Pendyala, Nivedita Venkatachalam

Faculty Research, Scholarly, and Creative Activity

Kolmogorov–Arnold Networks (KANs) have recently emerged as a powerful alternative to traditional Artificial Neural Networks (ANNs), offering superior accuracy and interpretability, which are two critical requirements in healthcare applications. This study investigates the effectiveness of KANs across a range of clinical tasks by applying them to diverse medical datasets, including structured clinical data and time-series physiological signals. Compared with conventional ANNs, KANs demonstrate significantly improved performance, achieving higher predictive accuracy even with smaller network architectures. Beyond performance gains, KANs offer a unique advantage: the ability to extract symbolic expressions from learned functions, enabling transparent, human-interpretable models—a key factor in clinical …

The Cohort Space As Experienced By Latina Doctoral Students, Tiana Bierwert

Graduate Doctoral Dissertations

This phenomenological study explores how Latina Doctoral Students experience cohort spaces within graduate programs, focusing on the gendered and racialized challenges embedded in these environments. Utilizing pláticas as a culturally grounded method and guided by a Latina Feminist Phenomenological framework, this research examines how cohort models—which are often designed to foster support and collaboration—can instead exacerbate marginalization for students at the intersections of race and gender. Drawing on the conceptual frameworks of White Space and Counterspace, the study interrogates how cohort environments can operate as sites of exclusion and surveillance, where dominant norms are reproduced and where Latina Doctoral Students …

Experiencing Race, Racism And Racialization In Transnational Contexts: Racial Literacies Of First-Year International Asian Students., Nasiba Norova

Graduate Doctoral Dissertations

This research focused on exploring the racial literacies of first-year international East Asian (EA) students, specifically examining their perceptions of and experiences with race, racism, and racialized groups in various social and educational contexts in both their home countries and the United States. The study used critical ethnography to examine the perspectives of EA international students and composition faculty. It involved multiple semi-structured interviews, journal entries, racial literacy autobiographies, site document analysis, and class observations to understand how students perceived exposure to race, racism, and racialized groups and how faculty viewed the importance of racial education for international students in …

Msw Portfolio, Andrea C. Lawrence

Graduate Student Portfolios, Professional Papers, and Capstone Projects

No abstract provided.

Master Of Social Work, Tanner J. Bailey

Graduate Student Portfolios, Professional Papers, and Capstone Projects

This portfolio documents my academic and professional development throughout the Master of Social Work (MSW) program at the University of Montana. Using my practicum experiences in juvenile probation and anonymous crisis intervention work, this paper integrates critical reflection, theory-informed application, and evidence-based practice to demonstrate my readiness as an advanced integrated social work practitioner.

Guided by the five elements of advanced integrated practice, the portfolio is structured around the ten core competencies outlined by the National Association of Social Workers (NASW). Key theoretical frameworks such as Cognitive Behavioral Therapy (CBT), Motivational Interviewing (MI), and trauma-informed care are discussed in relation …

Advocacy, Equity, And Impact: My Journey Through Social Work Practice, Stephanie L. Shaw

Graduate Student Portfolios, Professional Papers, and Capstone Projects

This portfolio presents a comprehensive overview of my graduate-level social work education and field experiences, demonstrating mastery of the core competencies outlined by the Council on Social Work Education and the University of Montana School of Social Work. Through rigorous coursework, evidence-based interventions, and direct practice in both clinical and community-based settings, I developed and applied critical skills in ethical practice, cultural humility, policy advocacy, and research-informed service delivery. This work reflects a strong integration of theory and practice, commitment to advancing social justice, and a readiness to enter the field as a competent, reflective, and ethical social worker.

Exploring Young Adults' Experiences And Beliefs In Asthma Medication Management: Pilot Qualitative Study Comparing Human And Multiple Ai Thematic Analysis, Ruth Ndarake Jeminiwa, Caroline Popielaski, Amber King

College of Pharmacy Faculty Papers

BACKGROUND: Young adults take their asthma maintenance medication 67% of the time or less. Understanding the specific needs and behaviors of young adults with asthma is essential for developing targeted interventions to improve disease self-management. Artificial intelligence (AI) has demonstrated its utility in summarizing and identifying patterns in qualitative research and may support or augment human coding efforts. However, there is pause literature to support this assertion.

OBJECTIVE: The objective of this study is to begin to explore the medication management-related needs of young adults with asthma via a pilot feasibility study. We aim to understand how to best assist …

A Comprehensive Study On The Use Of Sub-Coherent Self Heterodyne Linewidth Estimations, Genevieve Gutierrez

UNLV Theses, Dissertations, Professional Papers, and Capstones

A fundamental requirement for many precision spectroscopic applications is the development of stable lasers with narrow linewidths. However, accurately verifying laser linewidths becomes increasingly challenging as the linewidth decreases. In the field of frequency metrology, the delayed self-heterodyne technique has long been regarded as one of the most reliable and accessible methods for linewidth characterization, favored for its low equipment cost and reproducible results. Traditionally, self-heterodyne measurements employ an optical delay line significantly longer than the coherence length of the laser, with analysis performed via either the instantaneous power spectral density or the noise power spectral density. However, the use …