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The Role Individual Differences And Environmental Factors In Automated Driving Performance, John M. Duany Aug 2025

The Role Individual Differences And Environmental Factors In Automated Driving Performance, John M. Duany

Graduate Thesis and Dissertation post-2024

A series of experiments were conducted to investigate the effects of ADHD diagnosis, inclement weather, non-driving-related tasks (NDRT), automation failures, and traffic density on driving performance and takeover performance. This study also examined the relationship between dispositional factors (i.e., trust in automation, cognitive failures, and self-efficacy) and dynamic factors (i.e., mental workload, situation awareness, and situational trust) in relation to automated driving performance. A total of 156 participants were recruited for this study, including drivers with and without attention-deficit hyperactivity disorder (ADHD). Each participant completed four experimental drives and two baseline drives. Mental workload, heart rate variability (HRV), situational trust, …


Pride Or Prejudice: An Examination Of Queer Content In Florida High Schools, Niamh L. Harrop Aug 2025

Pride Or Prejudice: An Examination Of Queer Content In Florida High Schools, Niamh L. Harrop

Graduate Thesis and Dissertation post-2024

This thesis explores how queer individuals reflect on the presence—or more often, the absence—of queer content in their high school education. Despite increasing visibility of LGBTQ+ people in popular culture and legal reform, formal educational spaces remain largely heteronormative and cisnormative structured from a heterosexual and cisgender standpoint. Through a critical qualitative approach, this study draws on semi-structured interviews with 13 queer participants who attended high school in Florida in the years between the legalization of same-sex marriage in 2015 and the passage of Florida’s H.B. 1557 (“Don’t Say Gay” law) in 2022. Using thematic analysis, four key themes were …


Examining Educational Inequalities And Driving Science’S Next Generation Forward: Geobus Program Theory Evaluation, Elise M. Lorenzo Aug 2025

Examining Educational Inequalities And Driving Science’S Next Generation Forward: Geobus Program Theory Evaluation, Elise M. Lorenzo

Graduate Thesis and Dissertation post-2024

This study presents a theory-driven evaluation of GeoBus, a mobile science lab designed to deliver hands-on, “fun learning experiences” via a solar powered, technology-rich learning environment brought directly to K-12 students in Central Florida Title 1 schools. While STEM education is widely recognized as essential for promoting equity, many schools, particularly in under-resourced communities, continue to face barriers to accessing meaningful and inclusive science learning opportunities. GeoBus was created in response to this need, offering students an informal learning environment with exposure to geospatial technologies and interactive science content.

Drawing on mixed-methods data, including content from the GeoBus website and …


Staff Education On The Columbia-Suicide Severity Rating Scale, Nathlie Ndokame Aug 2025

Staff Education On The Columbia-Suicide Severity Rating Scale, Nathlie Ndokame

Walden Dissertations and Doctoral Studies

Summary This was a staff education project aimed at improving nurse knowledge on the Columbia-Suicide Severity Rating Scale (C-SSRS) tool. The identified gap in practice was a lack of knowledge and confidence among psychiatric nursing staff in utilizing this evidence-based suicide risk assessment tool. This project question was as follows: Does the implementation of an education program for psychiatric nursing staff on the use of the Columbia-Suicide Severity Rating Scale improve knowledge of patients at risk for suicide? The project employed the ADDIE framework and the Johns Hopkins evidence-based practice model. A comprehensive literature search was conducted, yielding 67 relevant …


The Speech-To-Song Illusion Across Development And The Effects Of High-Level Expectations, Rodica R. Constantine Aug 2025

The Speech-To-Song Illusion Across Development And The Effects Of High-Level Expectations, Rodica R. Constantine

UNLV Theses, Dissertations, Professional Papers, and Capstones

The typical listener can readily categorize auditory stimuli as either speech or song even though these structures share many acoustic similarities. These musical and linguistic categories may nevertheless take time to develop as children acquire language- and music-specific knowledge. In the Speech-to-Song (STS) illusion, multiple repetitions of a natural spoken utterance can give rise to a perceptual switch wherein the stimulus begins to sound song-like to the listener. While the STS illusion has been well-researched in adult listeners, it had yet to be investigated in children. In our study, we examined whether children experience the STS illusion by presenting participants …


Development Of An Access Charge Framework For High-Speed Rail Incorporating Rail Replacement Costs And Dynamic Train Characteristics, Nitesh Kumar Yadav Aug 2025

Development Of An Access Charge Framework For High-Speed Rail Incorporating Rail Replacement Costs And Dynamic Train Characteristics, Nitesh Kumar Yadav

UNLV Theses, Dissertations, Professional Papers, and Capstones

This thesis develops a framework to determine track access charges for shared high-speed rail corridors, with a focus on rail replacement cost driven by train-induced loads. The method explicitly accounts for both static loads, resulting from axle weights, and dynamic loads that arise from train speed and track geometry, particularly curvature. Train characteristics such as axle load, operating speed, frequency of service, and number of wheels are integrated with track parameters, including curve radius, to calculate the total vertical load. These loads are used to estimate the cumulative tonnage threshold for rail replacement and the resulting service life of the …


Lipidomic And Proteomic Insights From Extracellular Vesicles In The Postmortem Dorsolateral Prefrontal Cortex Reveal Substance Use Disorder-Induced Brain Changes, Chioma M Okeoma, Wasifa Naushad, Bryson C Okeoma, Carlos Gartner, Yulica Santos-Ortega, Calvin Vary, Savio Lima-Bastos, Victor Corasolla Carregari, Martin R Larsen, Alessio Noghero, Consuelo Walss-Bass, Rodrigo Grassi-Oliveira Aug 2025

Lipidomic And Proteomic Insights From Extracellular Vesicles In The Postmortem Dorsolateral Prefrontal Cortex Reveal Substance Use Disorder-Induced Brain Changes, Chioma M Okeoma, Wasifa Naushad, Bryson C Okeoma, Carlos Gartner, Yulica Santos-Ortega, Calvin Vary, Savio Lima-Bastos, Victor Corasolla Carregari, Martin R Larsen, Alessio Noghero, Consuelo Walss-Bass, Rodrigo Grassi-Oliveira

Faculty, Staff and Student Publications

Substance use disorder (SUD) significantly increases the risk of neurotoxicity, inflammation, oxidative stress, and impaired neuroplasticity. The activation of inflammatory pathways by substances may lead to reactive astrogliosis and chronic neuroinflammation, potentially mediated by the release of extracellular particles (EPs), such as extracellular condensates (ECs) and extracellular vesicles (EVs). These particles, which reflect the physiological, pathophysiological, and metabolic states of their cells of origin, might carry molecular signatures indicative of SUD. In particular, our study investigated neuroinflammatory signatures in SUD patients by isolating EVs from the dorsolateral prefrontal cortex (dlPFC) Brodmann's area 9 (BA9) from postmortem subjects. We isolated BA9-derived …


Mathematical Modeling And Association Analysis Decipher The Impact Of The Gut Microbiome On Cancer Immunotherapy, Andreas G Hadjigeorgiou, Constantinos Harkos, Aditya K Mishra, Golnaz Morad, Sarah B Johnson, Nadim J Ajami, Jennifer A Wargo, Lance L Munn, Triantafyllos Stylianopoulos, Rakesh K Jain Aug 2025

Mathematical Modeling And Association Analysis Decipher The Impact Of The Gut Microbiome On Cancer Immunotherapy, Andreas G Hadjigeorgiou, Constantinos Harkos, Aditya K Mishra, Golnaz Morad, Sarah B Johnson, Nadim J Ajami, Jennifer A Wargo, Lance L Munn, Triantafyllos Stylianopoulos, Rakesh K Jain

Faculty, Staff and Student Publications

The gut microbiome has emerged as a key regulator of response to cancer immunotherapy. However, a better understanding of the underlying mechanisms by which the microbiome influences immunotherapy is needed to identify strategies to optimize outcomes. To this end, we developed a mathematical model to obtain insights into the effect of the microbiome on the immune system and immunotherapy response. This model was based on (i) gut microbiome data derived from preclinical studies, (ii) mathematical modeling of the antitumor immune response, (iii) association analysis of microbiome profiles with model-predicted immune profiles, and (iv) statistical models that correlate model parameters with …


What Are The Predictors Of Malignancy In Inflammatory Bowel Disease?, Zülal İstemi̇han, Bi̇lger Çavuş, Ali̇ Emre Bardak, Ayşe Merve Kirkoğlu, Cansu Kiziltaş, Rüveyda Si̇lay, İbrahi̇m Volkan Şenkal, Zi̇ya İmanov, Kenan Nuri̇yev, Aynure Rüstemzade, Sezen Genç, Mi̇ne Güllüoğlu, Asli Çi̇fci̇başi Örmeci̇, Kadi̇r Demi̇r, Fati̇h Beşişik, Sabahatti̇n Kaymakoğlu, Fi̇li̇z Akyüz Aug 2025

What Are The Predictors Of Malignancy In Inflammatory Bowel Disease?, Zülal İstemi̇han, Bi̇lger Çavuş, Ali̇ Emre Bardak, Ayşe Merve Kirkoğlu, Cansu Kiziltaş, Rüveyda Si̇lay, İbrahi̇m Volkan Şenkal, Zi̇ya İmanov, Kenan Nuri̇yev, Aynure Rüstemzade, Sezen Genç, Mi̇ne Güllüoğlu, Asli Çi̇fci̇başi Örmeci̇, Kadi̇r Demi̇r, Fati̇h Beşişik, Sabahatti̇n Kaymakoğlu, Fi̇li̇z Akyüz

Turkish Journal of Medical Sciences

Background/aimː This study aims to investigate the prevalence of malignancy in patients with inflammatory bowel disease (IBD) followed up in a tertiary reference center.

Materials and methodsː IBD patients with at least 6 months of follow-up from the gastroenterology clinic between 2000 and 2022 wereevaluated retrospectively in a tertiary center. Patient information was obtained from the patient registration system.

Resultsː There were 697 patients in the study, 320 (45.9%) of these were female. The mean age of the patients at IBD diagnosis was 33.4± 13.1 years. The mean follow-up time was 93.1 ± 64.8 (median 84, IQR (25–75) (36–144)) months. …


Different Local Anesthetic Volumes In Pericapsular Nerve Group Block For Hip Fracture Patients, Yusuf Özgüner, Savaş Altinsoy, Gökçen Kültüroğlu, Sevda Gökçe Gürpinar, Derya Özkan, Jüli̇de Ergi̇l, Erbi̇l Aydin Aug 2025

Different Local Anesthetic Volumes In Pericapsular Nerve Group Block For Hip Fracture Patients, Yusuf Özgüner, Savaş Altinsoy, Gökçen Kültüroğlu, Sevda Gökçe Gürpinar, Derya Özkan, Jüli̇de Ergi̇l, Erbi̇l Aydin

Turkish Journal of Medical Sciences

Background/aim: The pericapsular nerve group (PENG) block is an effective method for pain management in patients with hip fractures. In our study, we compared three different local anesthetic volumes of the PENG block in patients who underwent surgery for hip fracture.Materials and methodsː Patients who underwent surgery with spinal anesthesia for intertrochanteric femur fractures (60 patients) were divided into three groups based on the volume of local anesthetic administered: Group 1 (20 mL), Group 2 (30 mL), and Group 3 (40 mL). Postoperative patient-controlled analgesia was initiated. Postoperative tramadol consumption, rest and movement pain scores, and the duration of motor …


Factors Affecting Extremity Fracture Risk In Children With Attention Deficit Hyperactivity Disorder, Yüksel Sümeyra Naralan, Esra Demi̇rel Aug 2025

Factors Affecting Extremity Fracture Risk In Children With Attention Deficit Hyperactivity Disorder, Yüksel Sümeyra Naralan, Esra Demi̇rel

Turkish Journal of Medical Sciences

Background/aim: Attention-Deficit/Hyperactivity Disorder (ADHD) is increasingly recognized not only for its behavioural and cognitive challenges but also for its potential implications in physical health, particularly injury risk. This study aimed to investigate the incidence of extremity fractures among children and adolescents diagnosed with ADHD and to evaluate the influence of demographic, clinical, and pharmacological variables—including ADHD subtypes and medication types—on fracture risk

Materials and Methods: This retrospective cross-sectional study included 754 children and adolescents aged 6–18 years who were diagnosed with ADHD according to DSM-5 criteria. Data were collected from electronic health records at a tertiary referral hospital. Variables …


Blood Group Profile Of Türkiye With Regional And Demographic Differences: A 23-Year Retrospective Study, Levent Sağdur, Azi̇z Karaca, Mustafa Nuri̇ Günçikan, Mustafa Yilmaz, Kerem Kinik Aug 2025

Blood Group Profile Of Türkiye With Regional And Demographic Differences: A 23-Year Retrospective Study, Levent Sağdur, Azi̇z Karaca, Mustafa Nuri̇ Günçikan, Mustafa Yilmaz, Kerem Kinik

Turkish Journal of Medical Sciences

Background/aim: This study aims to comprehensively analyze the distribution of ABO and Rh blood groups, as well as demographic characteristics and regional variations, using data from 9.5 million blood donors across Türkiye.

Materials and methods: In this multicenter, retrospective, cross-sectional study, data were collected from 9,587,592 healthy, voluntary donors who donated to the Turkish Red Crescent between 1998 and 2021. Donors met the criteria of being 18–70 years old, weighing over 50 kg, with hemoglobin levels above 13.5 g/dL for male and 12.5 g/dL for female. The data were evaluated based on age, gender, education level, and geographic region.

Results: …


Evaluation Of Teachers' Knowledge And Awareness About Autism Spectrum Disorder, Hami̇t Harun Bağci, Abi̇de Aksungur, Gülsüm Öztürk Emi̇ral, Erhan Şi̇mşek Aug 2025

Evaluation Of Teachers' Knowledge And Awareness About Autism Spectrum Disorder, Hami̇t Harun Bağci, Abi̇de Aksungur, Gülsüm Öztürk Emi̇ral, Erhan Şi̇mşek

Turkish Journal of Medical Sciences

Background/aim: Teachers play an essential role in the early identification of autism spectrum disorder (ASD) and associated difficulties in children. Increasing teachers’ knowledge of ASD can be helpful in identifying these children and making the necessary referrals. This study aimed to assess teachers’ knowledge and awareness of ASD and the factors affecting them.

Materials and methods: This is a cross-sectional study conducted among school counsellors. A total of 171 school counsellors were contacted; school visits were arranged by prior appointment, and the purpose of the study was explained. Data were collected using a questionnaire prepared by the researchers and the …


Consensus Paper On Candida Auris By Türkiye Ekmud, Thsk Of Ministry Of Health Of The Republic Of Türkiye, Klimud, Tmc, Tard, Tybd And Id-Iri, Canan Ağalar, Hakan Erdem, Yasemi̇n Çağ, Bi̇lgi̇n Arda, Recep Balik, Ali̇ye Baştuğ, Burcu Dalyan-Ci̇lo, Nuretti̇n Erben, Esma Eryilmaz-Eren, Gülşen İskender, Ayşe Kalkanci, Ni̇lgün Karabiçak, Zeli̇ha Koçak-Tufan, Emi̇ne Parlak, Nagehan Di̇dem Sari, Murat Sayin, Seni̇ha Şenbayrak, Recep Teki̇n, Ayşegül Ulu-Kiliç, Tuğhan Utku, Ömrüm Uzun, Göknur Yapar Toros, Sevtap Arikan-Akdağli Aug 2025

Consensus Paper On Candida Auris By Türkiye Ekmud, Thsk Of Ministry Of Health Of The Republic Of Türkiye, Klimud, Tmc, Tard, Tybd And Id-Iri, Canan Ağalar, Hakan Erdem, Yasemi̇n Çağ, Bi̇lgi̇n Arda, Recep Balik, Ali̇ye Baştuğ, Burcu Dalyan-Ci̇lo, Nuretti̇n Erben, Esma Eryilmaz-Eren, Gülşen İskender, Ayşe Kalkanci, Ni̇lgün Karabiçak, Zeli̇ha Koçak-Tufan, Emi̇ne Parlak, Nagehan Di̇dem Sari, Murat Sayin, Seni̇ha Şenbayrak, Recep Teki̇n, Ayşegül Ulu-Kiliç, Tuğhan Utku, Ömrüm Uzun, Göknur Yapar Toros, Sevtap Arikan-Akdağli

Turkish Journal of Medical Sciences

Candida auris is an emerging fungal pathogen that has become a critical global health concern due to its high antifungal resistance and potential to cause nosocomial outbreaks. Since its initial identification in Japan in 2009, C. auris has spread rapidly, posing significant treatment challenges across various healthcare settings worldwide. The biofilm formation ability of C. auris enhances its resilience against disinfectants and antifungal agents, complicating infection control in healthcare environments. This consensus report, developed with the collaboration of several Turkish medical specialty societies, including the Turkish Society of Infectious Diseases and Clinical Microbiology Specialty (EKMUD), the Turkish Society of Anesthesiology …


The Benefits Of Establishing Attending Behavior Prior To The Discriminative Stimulus During Discrete-Trial Instruction: A Systematic Review, Ruben S. Pereira Aug 2025

The Benefits Of Establishing Attending Behavior Prior To The Discriminative Stimulus During Discrete-Trial Instruction: A Systematic Review, Ruben S. Pereira

Seton Hall University Dissertations and Theses (ETDs)

Discrete trial instruction (DTI) is one of the most effective and commonly used instructional strategies for teaching individuals with autism. Researchers and professionals have informally promoted the importance of establishing attending behavior prior to initiating discrete trials. However, some researchers have reported a lack of literature analyzing the effects of establishing attending behavior, prior to instruction, on skill acquisition. Therefore, the benefits of establishing attending as part of DTI remain unknown. The goal of the current thesis was to conduct a systematic review using PRISMA guidelines to search for published studies where attending behavior was a primary independent variable within …


Colostrum Extracellular Vesicle Are Neuroprotective In The Mptp Intoxicated Mouse Model Of Parkinson's Disease, Samia Akter Aug 2025

Colostrum Extracellular Vesicle Are Neuroprotective In The Mptp Intoxicated Mouse Model Of Parkinson's Disease, Samia Akter

Theses & Dissertations

Parkinson’s Disease (PD) is the second most common neurodegenerative disorder. Dopaminergic neuronal loss in the substantia nigra and the formation of Lewy bodies are the disease pathological hallmarks. We demonstrate that bovine colostrum extracellular vesicles (EVs) induce anti-inflammatory and neuroprotective activities during MPTP (methyl-4-phenyl-1,2,3,6-tetrahydropyridine) intoxication. Treatment these mice with colostrum EVs reduced the extent of activated microglia and neurodegenerative activities. RNA sequencing and transcriptomic analysis revealed a significant decrease in pro- inflammatory responses, as well as reduced recruitment and activation of immunocytes in affected brain tissues. Decreased expression of pro-inflammatory cytokines and chemokines, as well as suppressed canonical inflammasomes, was …


Synthesis, Characterization, Biological Activity And Antioxidant Studies Of New Metal Ion Complexes Based On (E)-4-((Benzo[D]Thiazol-2-Ylimino)Methyl)-1,5-Dimethyl-2-Phenylpyrazolidin-3-One, Rafah Saad Talib, Naser Shaalan Aug 2025

Synthesis, Characterization, Biological Activity And Antioxidant Studies Of New Metal Ion Complexes Based On (E)-4-((Benzo[D]Thiazol-2-Ylimino)Methyl)-1,5-Dimethyl-2-Phenylpyrazolidin-3-One, Rafah Saad Talib, Naser Shaalan

Baghdad Science Journal

The study involved synthesis of four new complexes involving bidentate ligand [(E)-4-((benzo[d]thiazol-2-ylimino) methyl)-1,5-dimethyl-2-phenylpyrazolidin-3-one] with the general formula [M(L)2Cl2].xH2O or [MLCl2]. xH2O, where M represents Mn2+, Co2+, Ni2+ and Cu2+. The ligand was synthesized by treating the 4-Antipyrinecarboxaldehyde and 2-aminobenzothiazoles in an alcoholic solution. The structural characteristics of ligand and complexes were characterized quantitatively and qualitatively by using various techniques including elemental analyses, magnetic susceptibility measurement, molar conductivity, infrared, ultraviolet absorption, Gc-Mass, and 1H-NMR spectroscopy studies. The physical measurements indicated that the prepared …


Red Noise Suppression In Pulsar Timing Array Data Using Adaptive Splines, Yi-Qian Qian, Yan Wang, Soumya Mohanty Aug 2025

Red Noise Suppression In Pulsar Timing Array Data Using Adaptive Splines, Yi-Qian Qian, Yan Wang, Soumya Mohanty

Physics & Astronomy Faculty Publications

Noise in Pulsar Timing Array (PTA) data is commonly modeled as a mixture of white and red noise components. While the former is related to the receivers, and easily characterized by three parameters (EFAC, EQUAD and ECORR), the latter arises from a mix of hard to model sources and, potentially, a stochastic gravitational wave background (GWB). Since their frequency ranges overlap, GWB search methods must model the non-GWB red noise component in PTA data explicitly, typically as a set of mutually independent Gaussian stationary processes having power-law power spectral densities. However, in searches for continuous wave (CW) signals from resolvable …


Randomised, Placebo-Controlled Trial Of Oral Hymecromone In Adults With Pulmonary Hypertension, Kathryn Czepiel, Nadine Nagy, Tamera Panjalingam, Anissa Kalinowski, Adam R Frymoyer, Harry Karmouty-Quintana, Bo Gu, Haley Hedlin, Gernot Kaber, Sylvie Dobrota Lai, Joelle I Rosser, Paul L Bollyky, Vinicio De Jesus Perez, Roham T Zamanian Aug 2025

Randomised, Placebo-Controlled Trial Of Oral Hymecromone In Adults With Pulmonary Hypertension, Kathryn Czepiel, Nadine Nagy, Tamera Panjalingam, Anissa Kalinowski, Adam R Frymoyer, Harry Karmouty-Quintana, Bo Gu, Haley Hedlin, Gernot Kaber, Sylvie Dobrota Lai, Joelle I Rosser, Paul L Bollyky, Vinicio De Jesus Perez, Roham T Zamanian

Faculty, Staff and Student Publications

Background: Pulmonary hypertension (PH) is a progressive cardiopulmonary condition associated with increased morbidity and mortality. The extracellular matrix component hyaluronan (HA) is linked to vascular remodelling and interstitial fibrosis in PH. We hypothesised that inhibition of HA synthesis with hymecromone could serve as a reverse-remodelling therapy in PH.

Methods: We performed a proof-of-concept phase IIa randomised, double-blind, placebo-controlled study in adults with pulmonary arterial hypertension and PH associated with interstitial lung disease (PH-ILD). Patients were randomised to a 5:3 ratio and stratified by PH group to receive oral hymecromone or placebo two times per day over 24 weeks. The primary …


Role Of Immunosuppressive Jnk Pathway In The Tumor Microenvironment Among Tnbc Subtypes In Ibcsg Trial 22–00, Andrea Joaquin Garcia, Takashi Semba, Mattia Rediti, Daniel J Mcgrail, Xuemei Xie, Xiaoping Wang, Dileep R Rampa, David Venet, Laurence Buisseret, Samira Majjaj, Roswitha Kammler, Marco Colleoni, Sherene Loi, Giuseppe Viale, Meredith M Regan, Françoise Rothé, Christos Sotiriou, Naoto T Ueno Aug 2025

Role Of Immunosuppressive Jnk Pathway In The Tumor Microenvironment Among Tnbc Subtypes In Ibcsg Trial 22–00, Andrea Joaquin Garcia, Takashi Semba, Mattia Rediti, Daniel J Mcgrail, Xuemei Xie, Xiaoping Wang, Dileep R Rampa, David Venet, Laurence Buisseret, Samira Majjaj, Roswitha Kammler, Marco Colleoni, Sherene Loi, Giuseppe Viale, Meredith M Regan, Françoise Rothé, Christos Sotiriou, Naoto T Ueno

Faculty, Staff and Student Publications

Phosphorylation of the JNK (pJNK) protein promotes an immunosuppressive tumor microenvironment (TME), enhancing aggressiveness in inflammatory triple-negative breast cancer (TNBC). This study evaluated the role of JNK signaling using a gene signature. RNA sequencing was performed on 347 TNBC tumors from the phase 3 International Breast Cancer Study Group (IBCSG) 22-00 trial, which evaluated adjuvant low-dose cyclophosphamide and methotrexate (CM). Immune-related tumors were identified by TNBC subtype or tumor-infiltrating lymphocytes (TILs). Associations between JNK and outcomes were analyzed using Cox models. Low pJNK levels were associated with better disease-free survival (DFS) in immune-related tumors. These tumors also had lower Treg …


Highly Potent And Subtype-Selective Sperm-Specific Potassium Channel Slo3 Inhibitors Display High Tissue Exposure In The Murine Female Reproductive Tract, Kayla J Temple, Ping Li, Maximilian D Lyon, Shweta Bhagwat, Leila Asadi, Sophia Li, Ronald Mccarthy, Celia M Santi, Et Al. Aug 2025

Highly Potent And Subtype-Selective Sperm-Specific Potassium Channel Slo3 Inhibitors Display High Tissue Exposure In The Murine Female Reproductive Tract, Kayla J Temple, Ping Li, Maximilian D Lyon, Shweta Bhagwat, Leila Asadi, Sophia Li, Ronald Mccarthy, Celia M Santi, Et Al.

2020-Current year OA Pubs

To date, the study of drug exposure and distribution throughout the female reproductive tract has often been overlooked and neglected. Herein, we report the first highly potent and subtype-selective sperm-specific potassium channel 3 (SLO3) inhibitors as a new modality of contraceptives. After extensive


Isolation And Divergence Of Greater Earless Lizards (Phrynosomatidae: Cophosaurus) In Western North America Support Multiple Diversification Processes And A Complex Demographic History, Christopher Robert Blair, Carlos Joaquín Pavón-Vázquez, Qaantah Rana, Keaka Farleigh, Erika Crispo, Thomas Panzera, Felipe De Medeiros Magalhães, Britt White, Uri Omar Garcia-Vazquez Aug 2025

Isolation And Divergence Of Greater Earless Lizards (Phrynosomatidae: Cophosaurus) In Western North America Support Multiple Diversification Processes And A Complex Demographic History, Christopher Robert Blair, Carlos Joaquín Pavón-Vázquez, Qaantah Rana, Keaka Farleigh, Erika Crispo, Thomas Panzera, Felipe De Medeiros Magalhães, Britt White, Uri Omar Garcia-Vazquez

Publications and Research

The Southwestern US and northern Mexico continue to serve as ideal regions to elucidate the suite of ecological and evolutionary processes influencing lineage diversification. The complex geological history of arid North America, coupled with paleoclimate change during the Pleistocene and diverse ecoregions makes a multipronged approach to hypothesis testing necessary. We combine thousands of loci from a genotyping-by-sequencing (GBS) approach along with mitochondrial DNA (mtDNA) sequences from the Greater Earless Lizard (Cophosaurus texanus) to examine diversity and test for cryptic population structure. We also apply recently developed coalescent approaches in a Bayesian framework to estimate migration rates. Population …


Segmentation And Memory In Interactive, Inferential Events, Ata Baris Karagoz Aug 2025

Segmentation And Memory In Interactive, Inferential Events, Ata Baris Karagoz

Arts & Sciences Graduate Student Theses and Dissertations

Though everyday life is continuous, people tend to understand and remember experiences as discrete events separated by boundaries. Event segmentation theory (EST) (Zacks et al., 2007) describes these event boundaries as being driven by prediction error. People have an internal model of how an event unfolds, uses this to form predictions, and then places a boundary when a new model is necessary. Prior studies suggest that episodic memory is enhanced for information occurring near event boundaries, though less is known about these effects in interactive environments. To assess this, I designed an experimental paradigm where participants uncover changes in the …


Structure And Function Of Type 1 Pilus Assembly Machinery In Uropathogenic Escherichia Coli, Ryan Bitter Aug 2025

Structure And Function Of Type 1 Pilus Assembly Machinery In Uropathogenic Escherichia Coli, Ryan Bitter

Arts & Sciences Graduate Student Theses and Dissertations

Gram-negative bacteria produce chaperone-usher pathway (CUP) pili, which are extracellular adhesive protein fibers critical for host-pathogen interactions. An outer-membrane usher protein, together with a periplasmic chaperone, assembles thousands of pilin subunits into a pilus fiber. Each pilus is tipped by an adhesin that mediates host and tissue tropisms by binding to receptors with stereochemical specificity. Type 1 pili expressed by uropathogenic Escherichia coli (UPEC) are essential virulence factors in urinary tract infections (UTIs) and facilitate attachment to mannosylated glycoproteins on bladder epithelial cells. Although type 1 pili have been extensively studied, critical gaps remain in our understanding of the molecular …


Unveiling Mysteries Of The Universe: Axions, Sterile Neutrinos, And Curvatons, Takuya Okawa Aug 2025

Unveiling Mysteries Of The Universe: Axions, Sterile Neutrinos, And Curvatons, Takuya Okawa

Arts & Sciences Graduate Student Theses and Dissertations

The Standard Model of particle physics and cosmology is amazingly successful in describing our universe, from at present to even tracing back to just one second after its birth. Yet, it is known to be incomplete. For instance, (i) more than four-fifths of matter in the universe is unknown, (ii) quantum chromodynamics is unnaturally of CP-preserving nature, (iii) the universe produced baryonic particles by nearly equal but slightly larger amount compared to anti-baryonic particles, and (iv) the physics at very early times is not understood yet. This thesis first briefly summarizes the Standard Model of particle physics and cosmology, and …


Butte Priority Soils Operable Unit (Bpsou) Revised Butte Hill Revegetation Specifications, Mike Mcanulty, Eric Hassler Aug 2025

Butte Priority Soils Operable Unit (Bpsou) Revised Butte Hill Revegetation Specifications, Mike Mcanulty, Eric Hassler

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


From Sim To 6dof: Deep Learning For Real-Time Satellite Pose Estimation From Resolved Ground-Based Imagery, Thomas W.N. Dickinson Aug 2025

From Sim To 6dof: Deep Learning For Real-Time Satellite Pose Estimation From Resolved Ground-Based Imagery, Thomas W.N. Dickinson

Theses

This dissertation presents the first practical system for automated six degrees of freedom (6DOF) satellite pose estimation from resolved ground-based adaptive optics (AO) imagery. Addressing a key challenge in Space Domain Awareness (SDA), the proposed approach eliminates the need for human labeling by directly regressing satellite orientation and position from blurry, noisy, and deeply-shadowed imagery. The architecture consists of a multi-stage deep neural network pipeline that localizes the satellite, predicts pose, and optionally smooths predictions over time. Networks are trained exclusively on fully synthetic imagery generated from a 3D CAD model. Despite this, the model generalizes effectively, bridging the Sim2Real …


Spectroscopy Pre-Trained Transformer (Specpt): A Universal Spectroscopic Analysis And Redshift Measurement Framework, Rohan Pattnaik Aug 2025

Spectroscopy Pre-Trained Transformer (Specpt): A Universal Spectroscopic Analysis And Redshift Measurement Framework, Rohan Pattnaik

Theses

Spectroscopic surveys are essential for measuring galaxy redshifts and probing the physical processes driving galaxy evolution. As datasets grow in scale and complexity, traditional analysis methods face increasing limitations, motivating the development of scalable, data-driven alternatives. This thesis presents SpecPT, a transformer-based deep learning framework for general-purpose spectroscopic analysis, with a focus on redshift estimation. The model is first trained on DESI Early Data Release spectra from the Bright Galaxy and Emission Line Galaxy samples, jointly performing spectral reconstruction and redshift regression while learning a latent representation that captures the intrinsic properties of galaxies. SpecPT is then extended to a …


Fort Hays State University Tiger Weekly, August 15, 2025, University Relations Aug 2025

Fort Hays State University Tiger Weekly, August 15, 2025, University Relations

Tiger Weekly Newsletters

No abstract provided.


Seasonality In Terminus Ablation Rates For The Glaciers In Greenland (Kalaallit Nunaat), K. C. Aman, Ellyn M. Enderlin, Dominik Fahrner, Twila Moon, Dustin Carroll Aug 2025

Seasonality In Terminus Ablation Rates For The Glaciers In Greenland (Kalaallit Nunaat), K. C. Aman, Ellyn M. Enderlin, Dominik Fahrner, Twila Moon, Dustin Carroll

Faculty Research, Scholarly, and Creative Activity

Marine-terminating glaciers of Greenland (Kalaallit Nunaat) have been losing mass since the 1990s, with a substantial portion caused by the effects of dynamic change. Conventional assessments of dynamic mass loss, however, often ignore the influence of terminus advance or retreat on the timing of mass loss. Here, we construct and analyze a decade (2013-2023) of monthly ice flux driven both by temporal variability in ice flow (i.e., discharge) and terminus position change - collectively called terminus ablation - for 49 marine-terminating glaciers in Greenland. We calculate terminus ablation rates using open-source datasets, including terminus position, ice surface elevation, ice thickness, …