Digital Commons Network^™

Vessel-Specific Myocardial Mass In Patients With Stable Coronary Artery Disease, Nikolaos Stalikas, Takuya Mizukami, Frederic Bouisset, Kazumasa Ikeda, Atomu Tajima, Daniel Munhoz, Thabo Mahendiran, Adriaan Wilgenhof, Koshiro Sakai, Bjarne Noorgard, Thomas Engstroem, Jonathon Leipsic, Giulio Stefanini, Antonio Bartorelli, Timothy Fairbairn, Alan Bagnall, Brian Ko, Nils P Johnson, Colin Berry, Divaka Perera, Evald Høj Christiansen, Toshiro Shinke, Hiromase Otake, Bon Kwon Koo, Emanuele Barbato, Salvatore Brugaletta, Damien Collison, Gianluca Campo, Eric Van Belle, Tommaso Goori, Lokien Van Nunen, Adam Witkowski, Patricio Astudillo, James Spratt, Tetsuya Amano, Hirohiko Ando, Georgios Sianos, Jeroen Sonck, Daniele Andreini, Bernard De Bruyne, Carlos Collet

Faculty, Staff and Student Publications

Background: Assessing the myocardial mass at risk is essential in evaluating patients with coronary artery disease. This study aims to establish reference values for vessel-specific myocardial mass derived from coronary computed tomography angiography, providing a quantitative assessment of the myocardial mass subtended by each epicardial vessel.

Methods: Left ventricular (LV) and vessel-specific myocardial mass were calculated from coronary computed tomography angiography using the Voronoi method in patients with stable coronary artery disease. Myocardial mass was quantified for each epicardial coronary artery with a diameter >1.5 mm.

Results: We included 948 patients with 9228 epicardial coronary artery branches. Mean age was …

Generative Ai And The Future Of The Scholarship Of Teaching And Learning: What Do We Stand To Gain Or Lose?, Kathryn C. Wymer

International Journal for the Scholarship of Teaching & Learning

Discussions about generative artificial intelligence (AI) seem to predominate current conversations about higher education. It is urgent for those engaged in the Scholarship of Teaching and Learning to evaluate how generative AI could be used appropriately in course development and evaluation, but it is also important for SoTL practitioners to research the potential pitfalls inherent in the use of generative AI for such purposes. This concept essay presents three key questions that need to be addressed in order to fill in research gaps about generative AI and SoTL. Answering these questions will help us advocate for the importance of SoTL …

Prognosis And Treatment Response Stratification According To Loss Of Proofreading (Lop), Giulia Maddalena, Fadl A Zeineddine, Saikat Chowdhury, Mohammad A Zeineddine, Abdelrahman M Yousef, Francesca Bergamo, Sara Lonardi, Timothy A Yap, Michael Geoffrey White, Michael J Overman, Scott Kopetz, John Paul Shen

Faculty, Staff and Student Publications

Background: Only a subset of polymerase epsilon (POLE) mutations is associated with hypermutant phenotype; we hypothesized that only loss-of-proofreading (LOP) POLE mutations are associated with favorable immunotherapy response.

Methods: This retrospective cohort study included a pan-cancer cohort of 69,223 patients from cBioPortal and a cohort of patients with 41 POLE mutant metastatic colorectal (CRC) treated with immunotherapy at the MD Anderson Cancer Center between January 2017 and May 2023. We evaluated prognosis according to POLE mutation functionality.

Results: In the pan-cancer cBioPortal cohort (n=69,223) POLE was mutated in 2.8% (1,965) of tumors; of these, only 7.5% (n=148) had …

Humeral Head Retroversion On A Contemporary Skeletal Population With Known Physical Activity To Investigate The Differential Expressions Of Biological Sex, Elizabeth Hightower

Electronic Theses and Dissertations 2020 - Present

Retroversion is an angled measurement of the humerus that is indicative of habitual overhand activity. Elevated retroversion measurements (in degrees) indicate overhand activity. Overhand activity indicates subsistence gathering from spear or atlatl throwing. Most retroversion research is conducted in populations where men perform more physically demanding labor. Therefore, bioarchaeologists are producing the same data over and over. Additionally, contemporary retroversion data is used as comparative figures. These subjects range from youth to professional baseball players, but the data on women is nearly obsolete. Bioarchaeology needs contemporary female retroversion data. Research was conducted at the University of Tennessee Knoxville where humeral …

Heat And Kidney Health: Exploring The Impact Of Rising Temperatures On Kidney Health And Vulnerable Populations, Hoimonty Mazumder

Electronic Theses and Dissertations Archive

This dissertation examines how ambient temperature influences renal health across three complementary chapters by exploring: sex-stratified temperature-urine biomarkers relationships, a global comprehensive synthesis of evidence on renal colic, and mediation effect of BP in the biological pathway between ambient temperature and proteinuria. We used repeated measurements of urinary electrolytes, 24-h urine total protein (UTP), and volume as outcomes from a stepped-wedge RCT conducted in southwest coastal Bangladesh and collected daily ambient temperature data from Bangladesh Meteorological Board (BMD). We employed piece-wise linear mixed effect models using random intercepts to demonstrate ambient temperature and urine biomarker’s relationships. We summarized global evidence …

Pedagogical Training And Support Systems For Graduate Teaching Assistants, Alina Zaman

Electronic Theses and Dissertations Archive

Computer science relies heavily on graduate teaching assistants (GTAs), yet most training available to them is generic, not tailored to CS pedagogy, and rarely responsive to the needs of international GTAs. At the same time, rising enrollments and limited instructional capacity make timely, high-quality feedback on code both essential and difficult to deliver—especially in low-resource departments. This dissertation addresses that problem by pairing programmatic GTA preparation with assistive, human-in-the-loop AI and by empirically mapping where, how, and under what conditions AI can responsibly augment GTA feedback practice. First, I worked with the GTA training team to design and deploy a …

Quality Assessment Of Pathology Board-Exam-Style Mcqs Produced By Chatgpt3.5: A Comparative Study, Arianna B. Morton, Zunaira Naeem, Allison F. Goldberg, Alexis R. Peedin, Joanna Chan

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Residents preparing for pathology board exams frequently use multiple-choice questions (MCQs) from question banks (QBs) like PathDojo and PathPrimer, which can be costly. ChatGPT, a free tool, has been used to generate MCQs for other tests like the SAT. This study compared the quality of pathology MCQs created by ChatGPT versus commercially available study questions for the American Board of Pathology’s (ABPath) certifying exams. A rubric adapted from the National Board of Medical Examiners’ (NBME) question writing guide was validated by two pathologists using commercially available pathology board exam questions. This rubric was then used to evaluate MCQs from commercially …

Learning By Doing: The Importance Of Thoughtful And Limited Generative A.I. Use In The Il Legal Writing Classroom, Luke Repici

Faculty Publications

Technological advances that impact lawyers day-to-day work are nothing new. From typewriters, dictaphones, and computers to electronic legal research, email, and e-discovery, new technologies have changed the nuts and bolts of how lawyers practice for decades. Previous technologies may have replaced the pen with the typewriter and supplanted the letter for the email, but the lawyer remained the one doing the work. For more junior lawyers, this meant assigned tasks – reading cases, drafting motions, dictating client updates, summarizing discovery, and creating deposition outlines – could not be outsourced to technology.

The emergence of generative artificial intelligence (“Gen AI”) presents …

Elastic Cytomatrix Dynamics Influences Metabolic Rate And Tumor Microenvironment Formation, Tattym E Shaiken, Tulendy T Nurkenov, Meruyert S Kurmanbayeva, David Y Graham

Faculty, Staff and Students Publications

In healthy cells, the cytomatrix mechanics utilize mitochondrial respiration to control cytosolic motion and fine-tune the chemical processes. In cancer, the cytosolic motion is energized by glycolytic fermentation (the Warburg effect), which provides additional energy to supply the needs of the cytomatrix. Here, we describe the physical and chemical processes of the integrated and cooperative cytomatrix cytoarchitecture, in which structure and function are inseparable. The extracellular matrix is interconnected with the intracellular cytomatrix and functions as two integrated elastic solid phases. This finding led us to propose mechanisms of tumor microenvironment formation resulting from the mutational burden, in which altered …

Apathy Self-Awareness And Its Neural Correlates In Parkinson’S Disease, Hannah Conn, Hideo Suzuki, Zekai Jin, Ana Marin, Xi Zhu, Seonjoo Lee, Edward Huey, Ratko Radakovic, Sarah R Heilbronner, Nora Vanegas-Arroyave

Faculty, Staff and Students Publications

Apathy is a prevalent non-motor symptom in Parkinson's disease (PD) that negatively impacts quality of life. Impaired self-awareness of apathy (ISA-a) further impacts patient care by limiting engagement. While apathy has been associated with reduced fronto-striatal functional connectivity (FC), the neural basis of ISA-a remains unclear. We examined ISA-a in 52 individuals and the neural basis of ISA-a in 35 individuals with PD using a dimensional approach (i.e., initiation, executive, and emotional apathy) and resting-state fMRI (3T scanner). Apathetic PD patients (42%) showed poorer self-awareness than non-apathetic peers. Apathetic PD patients showed a trend towards reduced FC between the left …

Retinol Tracing Within Murine Neural Retina Reveals Cell Type-Specific Retinol Transport And Distribution, Zachary J Engfer, Grazyna Palczewska, Samuel W Du, Jianye Zhang, Zhiqian Dong, Carolline Rodrigues Menezes, Jun Wang, Jianming Shao, Budd A Tucker, Robert F Mullins, Rui Chen, Philip D Kiser, Krzysztof Palczewski

Faculty, Staff and Students Publications

11-cis-Retinal is essential for light perception in mammalian photoreceptors (PRs), and aberrations in retinoid transformations cause severe retinal diseases. Understanding these processes is crucial for combating blinding diseases. The visual cycle, operating within PRs and the retinal pigment epithelium (RPE), regenerates 11-cis-retinal to sustain light sensitivity. Retinoids are also present in Müller glia (MG), hypothesized to supply 11-cis-retinol to cone PRs and retinal ganglion cells (RGCs). To trace retinoid movement through retinal cell types, we used cell-specific knock-in of lecithin:retinol acyltransferase (LRAT), which converts retinols into stable retinyl esters (REs). Ectopic LRAT expression in murine PRs, MG, and RGCs resulted …

Improved Technical Outcomes With Converting Thrombectomy Techniques After Failed First Pass Recanalization, Hidetoshi Matsukawa, Charles Matouk, Kazutaka Uchida, Sami Al Kasab, Mohammad-Mahdi Sowlat, Sameh Samir Elawady, Ilko Maier, Pascal Jabbour, Joon-Tae Kim, Stacey Q Wolfe, Ansaar T Rai, Robert M Starke, Marios-Nikos Psychogios, Edgar A Samaniego, Adam S Arthur, Hugo Cuellar, Brain M Howard, Daniele G Romano, Omar Tanweer, Justin R Mascitelli, Isabel Fragata, Adam Polifka, Joshua W Osbun, Roberto Javier Crosa, Min S Park, Michael R Levitt, Waleed Brinjikji, Mark Moss, Richard Williamson, Pedro Navia, Peter Kan, Reade Andrew De Leacy, Shakeel A Chowdhry, Mohamad Ezzeldin, Alejandro M Spiotta, Shinichi Yoshimura, Ali M Alawieh

Faculty, Staff and Students Publications

Background: A higher number of recanalization attempts reduces the efficacy of endovascular thrombectomy (EVT) for acute ischemic stroke secondary to large vessel occlusion (LVO). We assessed the impact of switching EVT techniques after a failed first pass on procedural and clinical outcomes.

Methods: This multicenter international study, conducted between January 2013 and December 2022, included patients undergoing EVT for anterior circulation LVO (internal carotid artery or M1 segments) with failed first pass recanalization. Propensity score matching identified a 1:1 matched cohort of patients in whom EVT technique was changed after a failed first pass and those with the same technique …

Depth-Variant Deconvolution Applied To Widefield Microscopy For Rapid Large-Volume Tissue Imaging, Daniel D Lee, Kevin A Telfer, Mark A J Koenis, Yim K Lee, Kevin W Namink, Brian T Saunders, Heyun Lee, Hailey Kelley, Heather S Ruiz, Joseph P Gaut, Gwendalyn J Randolph, Bernd H Zinselmeyer

2020-Current year OA Pubs

Innovations in 3D tissue imaging have revolutionized research, but limitations stemming from lengthy protocols and equipment accessibility persist. Widefield microscopy is fast and accessible but often excluded from 3D imaging workflows due to its lack of optical sectioning. Here we combine tissue clearing with a commercial depth-variant deconvolution approach that we optimized for large-volume widefield imaging. By implementing prefiltering with z-brick splitting, we achieve subnuclear axial resolution in tissues to a depth of 500 µm in multi-tile scan images. We illustrate the utility of this method in a model of ileitis and to gain a 3D perspective in thick brain …

Building A Chatbot, Tracy A. Mendolia, Alyssa Denaro

AI Summit

No abstract provided.

Raising The Bar: Student Perceptions Of Ai Use In Education: Essay Writing, Grading, And Trust, Chad Tossell

AI Summit

No abstract provided.

Access, Accountability, And Ethics: Student Use Of Ai In The Classroom, Dawn M. Armfield

AI Summit

No abstract provided.

Tax Clinic, Thomas S. Oehring

Tax Adviser

No abstract provided.

Washington Report: The Taxpayers’ Bill Of Rights, Joel M. Forster

Tax Adviser

No abstract provided.

Tax Trends, E. S. Linett

Tax Adviser

No abstract provided.

Agribusiness: Operating As A Corporation, William L. Lucas, Arthur O. Wilkonson

Tax Adviser

No abstract provided.

“I’M From The Federal Government And I’M Here To Help”: An Examination Of How Firekeeper’S Daughter Educates About Settler Colonialism, Robert Petrone

Occasional Paper Series

This essay offers an examination of various ways Angeline Boulley’s best-selling, award-winning Indigenous Young Adult novel, Firekeeper’s Daughter attends to and educates about settler colonialism. At the core of this analysis is the guiding question: In what ways does Firekeeper’s Daughter illuminate the ongoing social structure of settler colonialism within the context of what is currently known as “The United States”? Specifically, this analysis focuses on the topics of Native identity, including colonial mechanism of blood quantum; and the ways institutions such as the FBI operate from values and epistemologies of compartmentalization and deficit notions of Native Peoples. Across this …

Making Connections To The Local: Exploring The Role Of Indigenous Literature In Early Childhood Education, Lori Huston, Dr. Jan Hare, Ashleigh Janis, Leigh Kweon

Occasional Paper Series

Indigenous children's literature is a vital resource for nurturing cultural understandings and appreciation from an early age for both Indigenous and non-Indigenous children. This paper presents insights gathered from a workshop titled "Nurturing Indigenous Childhoods Through Themed Picture Books: Making Connections to the Local," which emerged as a culmination of our collaborative work on a massive open online course (MOOC) centered on Indigenous pedagogy in early childhood education. We curated a list of Indigenous children's books and engaged in discussions on the significance of Indigenous literature in nurturing cultural identity and literacy learning. In doing so, we aspired to create …

The Legacy Of Language: Indigenous Language In Children’S Fiction, Christine Hartman Derr

Occasional Paper Series

Generally speaking, storytelling is an honored tradition in many Native communities. I use the term generally with a disclaimer. There are currently 574 federally recognized tribal Nations on the land presently known as the United States of America. There are additional Native Nations recognized at the state level and tribal Nations left unrecognized. Each Nation has its own culture, language, traditions, and beliefs. The statements made in this paper could not be universally applicable to all Indigenous communities. There is no monolithic Native perspective that could adequately represent every Native Nation, nor should there be. We celebrate our differences as …

The Tax Adviser, Volume 6, Number 10, October 1975, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.

Tax Trends, E. S. Linett

Tax Adviser

No abstract provided.

Washington Report: Tax Reform-Regulation Of Return Preparers, Joel M. Forster

Tax Adviser

No abstract provided.

Reits: Tax Considerations In Troubled Times, Barry S. Auerbach, Burton M. Mirsky

Tax Adviser

No abstract provided.

The Tax Adviser, Volume 6, Number 9, September 1975, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.

Tax Trends, E. S. Linett

Tax Adviser

No abstract provided.

Defending Against The Accumulated Earnings Tax, Luther W. Linch

Tax Adviser

No abstract provided.