Digital Commons Network^™

Relationship Between Cyp2d6 Genotype, Activity Score And Phenotype In A Pediatric Thai Population Treated With Risperidone., Yaowaluck Hongkaew, Andrea Gaedigk, Bob Wilffert, Nattawat Ngamsamut, Wiranpat Kittitharaphan, Penkhae Limsila, Chonlaphat Sukasem

Manuscripts, Articles, Book Chapters and Other Papers

Recently, the Clinical Pharmacogenetics Implementation Consortium (CPIC) have revised recommendations for the translation of CYP2D6 genotype to phenotype. Changes affect phenotype grouping, as well as the value used to calculate activity score for the CYP2D6*10 allele to better reflect the substantially decreased activity of this allele which is the most frequent allele found in Asian populations. This study aimed to evaluate whether the lower value for CYP2D6*10 as recommended, and the revised phenotype groupings improve the relationship between CYP2D6 genotype and risperidone measures. One hundred and ninety-nine children and adolescents with autism treated with a risperidone-based regimen for at least …

Correspondence Between Perceived Pubertal Development And Hormone Levels In 9-10 Year-Olds From The Adolescent Brain Cognitive Development Study., Megan M Herting, Kristina A Uban, Marybel Robledo Gonzalez, Fiona C Baker, Eric C Kan, Wesley K Thompson, Douglas A Granger, Matthew D Albaugh, Andrey P Anokhin, Kara S Bagot, Marie T Banich, Deanna M Barch, Arielle Baskin-Sommers, Florence J Breslin, B J Casey, Bader Chaarani, Linda Chang, Duncan B Clark, Christine C Cloak, R Todd Constable, Linda B Cottler, Rada K Dagher, Mirella Dapretto, Anthony S Dick, Nico Dosenbach, Gayathri J Dowling, Julie A Dumas, Sarah Edwards, Thomas Ernst, Damien A Fair, Sarah W Feldstein-Ewing, Edward G Freedman, Bernard F Fuemmeler, Hugh Garavan, Dylan G Gee, Jay N Giedd, Paul E A Glaser, Aimee Goldstone, Kevin M Gray, Samuel W Hawes, Andrew C Heath, Mary M Heitzeg, John K Hewitt, Charles J Heyser, Elizabeth A Hoffman, Rebekah S Huber, Marilyn A. Huestis, Luke W Hyde, M Alejandra Infante, Masha Y Ivanova, Joanna Jacobus, Terry L Jernigan, Nicole R Karcher, Angela R Laird, Kimberly H Leblanc, Krista Lisdahl, Monica Luciana, Beatriz Luna, Hermine H Maes, Andrew T Marshall, Michael J Mason, Erin C Mcglade, Amanda S Morris, Bonnie J Nagel, Gretchen N Neigh, Clare E Palmer, Martin P Paulus, Alexandra S Potter, Leon I Puttler, Nishadi Rajapakse, Kristina Rapuano, Gloria Reeves, Perry F Renshaw, Claudiu Schirda, Kenneth J Sher, Chandni Sheth, Paul D Shilling, Lindsay M Squeglia, Matthew T Sutherland, Susan F Tapert, Rachel L Tomko, Deborah Yurgelun-Todd, Natasha E Wade, Susan R B Weiss, Robert A Zucker, Elizabeth R Sowell

Institute of Emerging Health Professions Faculty Papers

Aim: To examine individual variability between perceived physical features and hormones of pubertal maturation in 9-10-year-old children as a function of sociodemographic characteristics.

Methods: Cross-sectional metrics of puberty were utilized from the baseline assessment of the Adolescent Brain Cognitive Development (ABCD) Study—a multi-site sample of 9–10 year-olds (n = 11,875)—and included perceived physical features via the pubertal development scale (PDS) and child salivary hormone levels (dehydroepiandrosterone and testosterone in all, and estradiol in females). Multi-level models examined the relationships among sociodemographic measures, physical features, and hormone levels. A group factor analysis (GFA) was implemented to extract latent variables of pubertal …

The New Hampshire, Vol. 110 [111], No. 49 (Feb. 18, 2021), The New Hampshire

The New Hampshire Print Edition

An independent student produced newspaper from the University of New Hampshire. This volume was printed as 110, but it is the 111th volume in the series. This was corrected in pencil.

State V. Jolley Respondent's Brief Dckt. 48139

Not Reported

No abstract provided.

State V. Atkinson Appellant's Brief Dckt. 48141

Not Reported

No abstract provided.

M.N.V. Holdings, L.C., Appelant V. 200 South Llc, Appelle : Brief Of Appellee, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

appeal from the Third Judicial District Court, Salt Lake County The Honorable Andrew Stone

Scott 0. Mercer J. Adam Knorr KESLER & Rust Attorneys for MN. V Holdings, L.C.

Greggory J. Savage Gregory S. Roberts RAY QUINNEY & NEBEKER P.C. Attorneys for Appellee 200 South LLC

Republican Autonomy : Extending Freedom As Non-Domination, Ezechiel Thibaud

Lingnan Theses (MPhil & PhD)

In political philosophy, the concept of autonomy is often associated with liberalism: it serves as a justification for the liberal values of state neutrality and value pluralism, and seems coherent with the liberal definition of freedom as the absence of interference. Neo-republicans have pointed out that freedom as non-interference fails to acknowledge the fact that one may be unfree while non-interfered with, while on the other hand, not all forms of interference are freedom-limiting. They have proposed to replace the concept by freedom as non-domination, which they define as the absence of actual or possible arbitrary interference. Although their definition …

Knowledge And Attitudes Among Healthcare Workers And Patients With Total Knee And Hip Replacement Towards The Use Of Brief Psychological Techniques: A Qualitative Study In Uk And Saudi Hospitals, T Alsanaani, A Norman, B Whalley

School of Psychology

No abstract provided.

February 18, 2021, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Vista: February 18, 2021, University Of San Diego

USD Vista (1965-)

No abstract provided.

Conducting Household Surveys On Reproductive Health In Urban Settings: Lessons From Karachi, Pakistan, Mirbaz Khan, Sidrah Nausheen, Imtiaz Hussain, Kristy Hackett, Kaneez Zehra, Khalid Feroz, David Cannin, Iqbal Shah, Sajid Bashir Soofi

Department of Paediatrics and Child Health

Background: Data collection is the most critical stage in any population health study and correctly implementing fieldwork enhances the quality of collected information. However, even the most carefully planned large-scale household surveys can encounter many context-specific issues. This paper reflected on our research team's recent experience conducting surveys for a quasi-experimental evaluation of a reproductive health program in urban areas of Karachi, Pakistan. We aim to describe the issues encountered and lessons learned from this process, and present some potential solutions for conducting future household surveys in similar urban environments.
Methods: The study followed a three-stage random sampling design. Initially, …

Epidemiology, Biostatistics, And Population Health Concepts, Allison R. Casola, Phd, Mph, Mches

Department of Family & Community Medicine Presentations and Grand Rounds

Overview

Study Designs

• Overview

Epidemiology and Biostatistics

• Vocabulary Review
• Reliability, Variability, and Bias
• Diagnostic Testing and Measures of Association

Population Health

• Evidence Based Medicine
• Interpreting and Evaluating Literature
• Clinical Decision Making

Ft-Cnn: Algorithm-Based Fault Tolerance For Convolutional Neural Networks, Kai Zhao, Sheng Di, Sihuan Li, Xin Liang, For Full List Of Authors, See Publisher's Website.

Computer Science Faculty Research & Creative Works

Convolutional neural networks (CNNs) are becoming more and more important for solving challenging and critical problems in many fields. CNN inference applications have been deployed in safety-critical systems, which may suffer from soft errors caused by high-energy particles, high temperature, or abnormal voltage. Of critical importance is ensuring the stability of the CNN inference process against soft errors. Traditional fault tolerance methods are not suitable for CNN inference because error-correcting code is unable to protect computational components, instruction duplication techniques incur high overhead, and existing algorithm-based fault tolerance (ABFT) techniques cannot protect all convolution implementations. In this paper, we focus …

Influence Of Sequential And Simultaneous Bilingualism On Second Grade Dual Language Students’ Use Of Syntax In Reading, Allison Briceño

Faculty Research, Scholarly, and Creative Activity

This study integrated reading and bilingual theories to examine the reading behaviors of second grade Latinx students in a Dual Language program. It explored how the students’ differing language backgrounds (simultaneous bilinguals and sequential bilinguals who had developed Spanish as a home language) might influence their early reading behaviors. Data sources include Spanish and English informal reading inventories and student interviews. While all students struggled with the syntax of grade-level text in Spanish and English, simultaneous bilinguals’ superior ability to use syntax to self-correct in both languages evidenced a stronger syntactical base. The findings have significant implications for equity of …

Sars-Cov-2 Early Infection Signature Identified Potential Key Infection Mechanisms And Drug Targets, Yue Li, Ashley Duche, Michael R. Sayer, Don Roosan, Farid G. Khalafalla, Rennolds S. Ostrom, Jennifer Totonchy, Moom Roosan

Pharmacy Faculty Articles and Research

Background

The ongoing COVID-19 outbreak has caused devastating mortality and posed a significant threat to public health worldwide. Despite the severity of this illness and 2.3 million worldwide deaths, the disease mechanism is mostly unknown. Previous studies that characterized differential gene expression due to SARS-CoV-2 infection lacked robust validation. Although vaccines are now available, effective treatment options are still out of reach.

Results

To characterize the transcriptional activity of SARS-CoV-2 infection, a gene signature consisting of 25 genes was generated using a publicly available RNA-Sequencing (RNA-Seq) dataset of cultured cells infected with SARS-CoV-2. The signature estimated infection level accurately in …

Measurement Of Information: A Review Article, Dariush Alimohammadi

Library Philosophy and Practice (e-journal)

Purpose - Measurement of information has long been studied for many years from different perspectives. Acknowledging this diversity, the article aims at reviewing approaches to the information measurement.

Design/methodology/approach – Literature review method was used to analyze and interpret main approaches of measuring information.

Findings - Logarithm, volume, syntax, probability and entropy, quantity, impact, value, and energy of information were identified and investigated in detail as the major approaches to the information measurement.

Originality/value - Discussing strengths and weaknesses of each approach, it concludes that a multi-dimensional approach would help us measure the information more accurate.

Limited Effects Of Long-Term Daily Cranberry Consumption On The Gut Microbiome In A Placebo-Controlled Study Of Women With Recurrent Urinary Tract Infections, Timothy J Straub, Wen-Chi Chou, Abigail L Manson, Henry L Schreiber 4th, Bruce J Walker, Christopher A Desjardins, Sinéad B Chapman, Kerrie L Kaspar, Orsalem J Kahsai, Elizabeth Traylor, Karen W Dodson, Meredith A J Hullar, Scott J Hultgren, Christina Khoo, Ashlee M Earl

2020-Current year OA Pubs

BACKGROUND: Urinary tract infections (UTIs) affect 15 million women each year in the United States, with > 20% experiencing frequent recurrent UTIs. A recent placebo-controlled clinical trial found a 39% reduction in UTI symptoms among recurrent UTI sufferers who consumed a daily cranberry beverage for 24 weeks. Using metagenomic sequencing of stool from a subset of these trial participants, we assessed the impact of cranberry consumption on the gut microbiota, a reservoir for UTI-causing pathogens such as Escherichia coli, which causes > 80% of UTIs.

RESULTS: The overall taxonomic composition, community diversity, carriage of functional pathways and gene families, and relative abundances …

Covid-19 Drugs And Medicines: A Scientometric Mapping Of Research Publications, Surulinathi Muthuraj, Arputha Sahayarani Y Research Scholar, Srinivasa Ragavan S Professor And Head, Library Information Science, Rajkumar N Research Scholar, Jayasuriya T Final Year Mlis

Library Philosophy and Practice (e-journal)

This paper attempts to highlight the growth and development of Covid-19 drugs and medicine literature and make the quantitative and qualitative assessment by way of analyzing various features of research output and Citations impact based on the Web of Science database. A total of 6425 publications were published on Covid-19 drugs and medicine, which received 313411 Citations during 2020-2021. In all, there were 140 countries involved in research in Covid-19 drugs and medicine. The most productive countries are USA highest share of 1814(28.4%) publications and received 17779 Citations followed by Peoples Republic of China with 18623 Citations for 986(15.5%) …

Issue Nineteen Full Text

SIGNED: The Magazine of The Hong Kong Design Institute

No abstract provided.

Gender Identity And Pronoun Usage In Standardized Patient Encounters, Martha M. Popescu, Emily J. Noonan, Laura A. Weingartner

Grawemeyer Colloquium Papers

One of the most common documentation frameworks clinicians use for patient evaluations are Subjective, Objective, Assessment, and Plan, (SOAP) notes. The clinician will usually record medical, family, social, etc. history as “subjective” information. Temperature, blood pressure, lab work, etc. would be considered “objective” information. An evaluation of the patient’s health and possible medical issues would be considered the “assessment,” and their intentions for current and future treatment would be the “plan” within these notes. Trainees often write SOAP notes after completing a standardized patient (SP) encounter—an educational practice used in medical schools to simulate real-world physician-patient interactions in order to …

Multi-Year Biological Control Of Black Vine Weevil, Otiorhynchus Sulcatus, With Persistent Entomopathogenic Nematodes, Elson J. Shields, Antonio M. Testa

The Great Lakes Entomologist

Abstract:

The black vine weevil (BVW), Otiorhynchus sulcatus Fabricius (Coleoptera: Curculionidae), has a worldwide distribution and is a serious pest of many agricultural crops with a host plant species range of 140 plants. Common economic losses occur in small fruits, including strawberries, ornamental and nursery plants, caused primarily by the root feeding larvae resulting in reduced vigor and plant death.

The susceptibility of BVW to entomopathogenic nematodes (EPNs) is well established with numerous authors publishing papers using a wide array of EPN species from commercial sources and very high application rates for use as a biopesticide. The concept of using …

Screamin' From The Zoo (A Preview), Elijah Jalil Paz Fisher

UM Graduate Student Research Conference (GradCon)

SCREAMIN’ FROM THE ZOO (SFTZ) is a one-person, Neo-Spiritual developed through SoulWork for partial fulfillment of my Final Creative Project (FCP) as a Master of Fine Arts (MFA) Acting Candidate with the University of Montana School of Theatre & Dance. Throughout the show, I share a capella songs, spoken word, and theatrical dialogue to explore stillness, hope, change, pain, freedom, grief, empowerment, joy and further within myself all in a search for what it means to have Soul.

In the words of Dr. Cristal Chanelle Truscott, “Defining Soul is a mind-bending, elusive exercise.” Dr. Truscott is the practitioner …

Uncharted Waters: Sustaining A Meaningful Student Teaching Experience Amidst A Global Pandemic Via An Online Stem Curriculum, Nanette I. Marcum-Dietrich, Cindy Stunkard, Zachary Krauss, Steve Kerlin

Current Issues in Middle Level Education

Field experience is the culminating experience for pre-service teacher training. As COVID-19 closed schools across the country, pre-service teachers’ field experiences were disrupted. This case study examines how a student teacher, a team of mentor teachers, and a university supervisor at a regional public university adapted to remote learning. The findings suggest that there were gains and losses in terms of the pre-service teachers’ ability to develop essential skills; classroom management skills suffered while formative assessment practices, innovative lesson delivery, and reflection on instruction were enhanced. The transition to remote learning also caused the way student teachers’ skills were valued, …

Strategies Addressing The English Language Arts Content Standards, Susan L. Adkins, Nancy L. Douglas

Michigan Reading Journal

No abstract provided.

Where In The World Of Ela Is Michigan Today? A Message From The Mra President, William J. Devers Iii

Michigan Reading Journal

No abstract provided.

Front Matter, Michigan Reading Journal

Michigan Reading Journal

No abstract provided.

Effects On Interpretation Bias, Mood, And Physical Tension During Mobile Device Usage: An Examination Of Slumped, Upright, And Lying Down Postures, Gabriela Flores-Cruz

The Pegasus Review: UCF Undergraduate Research Journal

The purpose of this study was to examine the effects of posture on interpretation bias, mood, and physical tension when using a mobile device. Participants were randomly assigned to one of three conditions: sitting slumped, sitting upright, or lying down. They were then asked to unscramble emotional and neutral sentences to measure interpretation bias. Self-reported measurements were used to measure mood and physical tension. No significant differences were found in the type of sentence unscrambled when sitting slumped and upright. When lying down, participants unscrambled fewer neutral sentences compared to emotional sentences. Physical tension was found to mediate the relationship …

If We Can Talk About It, We Can Write About It; If We Can Write About It, We Can Read About It, Katie Fisher

Michigan Reading Journal

No abstract provided.

Front Matter, Michigan Reading Journal

Michigan Reading Journal

No abstract provided.

Voices In Michigan Literacy: Michigan Teachers Interview The 2002 Newberry Award Winner, Linda M. Pavonetti

Michigan Reading Journal

No abstract provided.