Digital Commons Network^™

Metabolic Flexibility Across The Spectrum Of Glycemic Regulation In Youth, Fida Bacha, Sara Klinepeter Bartz, Maurice Puyau, Anne Adolph, Susan Sharma

Children’s Nutrition Research Center Staff Publications

BACKGROUNDMetabolic flexibility (MF) refers to the relative ability to utilize lipid and carbohydrate substrates and to transition between them. It is not clear whether MF is impaired in obese youth and what the determining factors are.METHODSWe investigated the determinants of MF (increased respiratory exchange ratio [ΔRER] under insulin-stimulated conditions) in pubertal youth (n = 104; 15.6 ± 1.8 years) with obesity across the spectrum of glucose tolerance compared with normal weight (NW) controls, including body composition (fat-free mass [FFM], %body fat), visceral adipose fat (VAT) (MRI), glycemia, and insulin sensitivity (IS) [3-hour hyperinsulinemic-euglycemic clamp with measurement of lipolysis ([2H5] glycerol), …

Kourtni Haskell, Plaintiff/ Appellant V. Wakefield & Assocait Es, Inc., And Matthew Frawley, An Individual, Defendants/ Appellees : Brief Of Appellant, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

Appeal from the Third Judicial District Court, Salt Lake County, State of Utah The Honorable Judge Andrew Stone

Attorneys for Appellees Mark A. Nickel, David Gamer

Attorneys for Appellant, Daniel Baczynski

Circulating Mitochondrial Dna Is An Early Indicator Of Severe Illness And Mortality From Covid-19, Davide Scozzi, Marlene Cano, Lina Ma, Dequan Zhou, Ji Hong Zhu, Jane A. O'Halloran, Charles Goss, Adriana M. Rauseo, Zhiyi Liu, Sanjaya K. Sahu, Mohsen Ibrahim, Ramsey Hachem, Daniel Kreisel, Philip A. Mudd, Hrishikesh S. Kulkarni, Andrew E. Gelman, Et Al

Open Access Publications

BackgroundMitochondrial DNA (MT-DNA) are intrinsically inflammatory nucleic acids released by damaged solid organs. Whether circulating cell-free MT-DNA quantitation could be used to predict the risk of poor COVID-19 outcomes remains undetermined.MethodsWe measured circulating MT-DNA levels in prospectively collected, cell-free plasma samples from 97 subjects with COVID-19 at hospital presentation. Our primary outcome was mortality. Intensive care unit (ICU) admission, intubation, vasopressor, and renal replacement therapy requirements were secondary outcomes. Multivariate regression analysis determined whether MT-DNA levels were independent of other reported COVID-19 risk factors. Receiver operating characteristic and area under the curve assessments were used to compare MT-DNA levels with …

Biotic Homogenization Or Riparian Refugia? Urban And Wild Land Snail Assemblages Along A Subtropical Precipitation Gradient, Kathryn E. Perez, Briante S. Lewis Najev, Bradley O. Christoffersen, Jeffrey C. Nekola

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

A noted impact of urbanization is the tendency for biotic homogenization, or the increase of similarity of geographically disparate communities. On the other hand, some urban habitats harbor biodiversity native to their region, a role potentially important in xeric landscapes, with irrigation increasing the coverage and availability of mesic habitats in an otherwise water-limited landscape. We assessed the relative importance of urban yards as agents of biotic homogenization or riparian refugia by characterizing community composition of Tamaulipan thornforest land snail assemblages across a pronounced precipitation gradient in far south Texas, USA. We quantified α- and β-diversity and assessed whether the …

Examining The Causal Impact Of Prenatal Home Visiting On Birth Outcomes: A Propensity Score Analysis, Elizabeth R. Anthony, Robert L. Fischer

Faculty Scholarship

Objectives: In Ohio, African American babies die at 2.5–3 times the rate of White babies. Preterm birth and low birth weight are the leading causes of infant mortality. Home visiting is an evidence-based strategy for serving low-income pregnant women; however, there are relatively few rigorous studies examining its effect on birth outcomes. Methods: This study uses a propensity score technique to estimate the causal effect of participation in home visiting on prematurity and low birth weight among a low-income, predominantly African American sample (N = 26,814). Results: We found that participation in home visiting significantly reduced the odds of experiencing …

Independently Controlling Stochastic Field Realization Magnitude And Phase Statistics For The Construction Of Novel Partially Coherent Sources, Milo W. Hyde Iv

Faculty Publications

In this paper, we present a method to independently control the field and irradiance statistics of a partially coherent beam. Prior techniques focus on generating optical field realizations whose ensemble-averaged autocorrelation matches a specified second-order field moment known as the cross-spectral density (CSD) function. Since optical field realizations are assumed to obey Gaussian statistics, these methods do not consider the irradiance moments, as they, by the Gaussian moment theorem, are completely determined by the field’s first and second moments. Our work, by including control over the irradiance statistics (in addition to the CSD function), expands existing synthesis approaches and allows …

Impact Of Dynamic Sub-Populations Within Grafted Chains On The Protein Binding And Colloidal Stability Of Pegylated Nanoparticles, Delyan Hristov, Hender Lopez, Yannick Ortin, Kate O'Sullivan, Kenneth A. Dawson, Dermot F. Brougham

Articles

Polyethylene glycol grafting has played a central role in preparing the surfaces of nano-probes for biological interaction, to extend blood circulation times and to modulate protein recognition and cellular uptake. However, the role of PEG graft dynamics and conformation in determining surface recognition processes is poorly understood primarily due to the absence of a microscopic picture of the surface presentation of the polymer. Here a detailed NMR analysis reveals three types of dynamic ethylene glycol units on PEG-grafted SiO2 nanoparticles (NPs) of the type commonly evaluated as long-circulating theranostic nano-probes; a narrow fraction with fast dynamics associated with the chain …

Hearing Threshold Levels Of Australian Coal Mine Workers: A Retrospective Cross-Sectional Study Of 64196 Audiograms, Adelle Liebenberg, Alan M. Brichta, Valerie M. Nie, Sima Ahmadi, Carole L. James

Research outputs 2014 to 2021

Objective: This study examined the hearing threshold levels (HTL) of workers commencing employment in Australian coal mines in the State of New South Wales (NSW). The aim was to establish if some degree of hearing loss was identifiable in the mandatory pre-employment audiograms of workers.

Design: This was an observational, retrospective, repeated cross-sectional study. Study Sample De-identified audiometric records of 64196 employees entering NSW coal mining in three representative five-year periods between 1991–2015 were utilised

Results: Although HTLs were lower (better) in more recent years, the results showed clinically significant hearing loss ( ≥ 25dBHL) for older workers, 45–60 years. …

Three-Dimensional Structure Of Human Cyclooxygenase (Hcox)-1., Morena Miciaccia, Benny Danilo Belviso, Mariaclara Iaselli, Gino Cingolani, Savina Ferorelli, Marianna Cappellari, Paola Loguercio Polosa, Maria Grazia Perrone, Rocco Caliandro, Antonio Scilimati

Department of Biochemistry and Molecular Biology Faculty Papers

The beneficial effects of Cyclooxygenases (COX) inhibitors on human health have been known for thousands of years. Nevertheless, COXs, particularly COX-1, have been linked to a plethora of human diseases such as cancer, heart failure, neurological and neurodegenerative diseases only recently. COXs catalyze the first step in the biosynthesis of prostaglandins (PGs) and are among the most important mediators of inflammation. All published structural work on COX-1 deals with the ovine isoenzyme, which is easier to produce in milligram-quantities than the human enzyme and crystallizes readily. Here, we report the long-sought structure of the human cyclooxygenase-1 (hCOX-1) that we refined …

Saudi Teachers’ Perceptions Of Rough-And-Tumble Play In Early Learning, Rana Alghamdi

USF Tampa Graduate Theses and Dissertations

This study explored teachers’ perceptions of rough-and- tumble (R&T) play in early childhood education in Saudi Arabia. The literature on rough-and-tumble play in Saudi Arabia is limited in scope, and more research is needed to explore teachers’ perceptions on this type of play for early learners. The pertinent literature reveals that R&T play, which includes running, jumping, fighting, wrestling, chasing, pulling, pushing, and climbing, among other rough playful activities, can positively impact learning and development across psychosocial, emotional, and cognitive domains. Teachers’ understanding of R & T play is key, and the attitudes of Saudi early childhood teachers who are …

Investigation Of The Structure And Dynamics Of Novel Battery Electrolytes By Utilizing Multidimensional Infrared Spectroscopic Techniques, Susith Rajitha Abeythunga Galle Kankanamge

LSU Doctoral Dissertations

Novel battery technologies are being developed due to the high global demand for energy in many fields where different specifications are required. The battery electrolyte provides a medium for ions to diffuse between electrodes and its composition determines the compatibility with the electrode pair. While many works focus on characterizing novel electrolyte systems to advance new batteries, the understanding of the microscopic structure and dynamics of speciations present in these electrolytes is limited. Many experiment methods have obtained incomplete time-averaged structure information due to lack of instrumental time resolution compared to the molecular intrinsic time sales of electrolytes that range …

A Prospective Surveillance Study On The Kinetics Of The Humoral Immune Response To The Respiratory Syncytial Virus Fusion Protein In Adults In Houston, Texas, Brittani N Blunck, Letisha Aideyan, Xunyan Ye, Vasanthi Avadhanula, Laura Ferlic-Stark, Lynn Zechiedrich, Brian E Gilbert, Pedro A Piedra

Faculty, Staff and Students Publications

Respiratory syncytial virus (RSV)-specific serum antibody has been correlated to protection of infection and reduction of severe disease, but reinfection is still frequent. In this study, we evaluated RSV-specific serum antibody activity following natural RSV re-infection to examine the longevity of the humoral immune response in adults. Nineteen healthy adult volunteers under sixty-five years of age were enrolled during the 2018-2019 RSV season in Houston, TX. Blood was collected at three study visits. The kinetics of RSV-neutralizing, RSV F site-specific competitive, and RSV-binding antibodies in serum samples were measured by microneutralization and enzyme-linked immunosorbent assays. Three distinct profiles of RSV-specific …

Scholarly Conversations, Intellectual Virtues, And Virtue Information Literacy, Wayne Bivens-Tatum

Library Philosophy and Practice (e-journal)

This article develops a concept of Virtue Information Literacy (VIL) modeled on the philosophical subfields of virtue ethics and virtue epistemology. VIL is an ethical, character-based approach analyzing information literacy through intellectual virtues and vices in order to cultivate such virtues with the goal of living a more flourishing life. The article explains the foundation of VIL in virtue ethics and virtue epistemology; analyzes recent work making similar connections between information literacy, virtue epistemology, and intellectual virtues and vices; and finally with the aid of Richard Rorty’s pragmatism and Hans-Georg Gadamer’s philosophical hermeneutics analyzes some intellectual virtues especially useful for …

The Second Ninds/Nibib Consensus Meeting To Define Neuropathological Criteria For The Diagnosis Of Chronic Traumatic Encephalopathy, Kevin F Bieniek, Nigel J Cairns, Et Al.

2020-Current year OA Pubs

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder associated with exposure to head trauma. In 2015, a panel of neuropathologists funded by the NINDS/NIBIB defined preliminary consensus neuropathological criteria for CTE, including the pathognomonic lesion of CTE as "an accumulation of abnormal hyperphosphorylated tau (p-tau) in neurons and astroglia distributed around small blood vessels at the depths of cortical sulci and in an irregular pattern," based on review of 25 tauopathy cases. In 2016, the consensus panel met again to review and refine the preliminary criteria, with consideration around the minimum threshold for diagnosis and the reproducibility of a proposed …

Cerebrovascular Segmentation From Mra Images, Fatma Taher, Ayman S El-Baz

Patents

There is provided a method of processing a cerebrovascular medical image, the method comprising receiving magnetic resonance angiography (MRA) image associated with a cerebrovascular tissue comprising blood vessels and brain tissues other than blood vessels; segmenting MRA image using a prior appearance model for generating first prior appearance features representing a first-order prior appearance model and second appearance features representing a second-order prior appearance model of the cerebrovascular tissue, wherein current appearance model comprises a 3D Markov-Gibbs Random Field (MGRF) having a 2D rotational and translational symmetry such that MGRF model is 2D rotation and translation invariant; segmenting MRA image …

Effect Of Reduced Plume Entrainment On The Burning Rate Of Porous Fuel Beds, Sara Mcallister

Progress in Scale Modeling, an International Journal

Large outdoor fires often exhibit unexpected fire behavior, particularly compared with much smaller fires. Understanding the difference between large- and small-scale fires is of importance for both fire behavior predictions and safety. Large fires are often characterized by very tall plumes that can extend to the stratosphere. Particularly as the actively burning area increases, plumes in large-scale fires likely entrain relatively little and may act in a similar fashion to a chimney. To explore the possible changes in burning rate due to the chimney effect, experiments were conducted with wood cribs burned with a chimney of variable height. The burning …

Welcome To The New Dignity, Donna M. Hughes

Dignity: A Journal of Analysis of Exploitation and Violence

No abstract provided.

Different Cooling Strategies Applied During Inter-Set Rest Intervals In High-Intensity Resistance Training, Gilmar J. Esteves, Renato A. Garcia, Paulo H. S. M. Azevedo

International Journal of Exercise Science

International Journal of Exercise Science 14(2): 295-303, 2021. The purpose of this study was to verify whether cooling between sets during high-intensity resistance exercise improves physical performance and to compare performance among different sites of cooling. It is important because delaying the muscular fatigue could improve total volume at a training session which could lead to greater hypertrophy. Nine healthy and recreational resistance training experienced men, performed six tests of a biceps curl exercise on different days. The first test was the one-repetition maximum test (1RM). Following, we applied five sessions, in crossover and randomized (counter-balanced) design. The subjects received …

Cross-Country Differences In Stay-At-Home Behaviors During Peaks In The Covid-19 Pandemic In China And The United States: The Roles Of Health Beliefs And Behavioral Intention, Wei Hong, Ru-De Liu, Yi Ding, Jacquenline Hwang, Jia Wang, Yi Yang

Covid-19 Digital Research

The novel coronavirus disease 2019 (COVID-19) rapidly escalated to a global pandemic. To control the rate of transmission, governments advocated that the public practice social distancing, which included staying at home. However, compliance with stay-at-home orders has varied between countries such as China and the United States, and little is known about the mechanisms underlying the national differences. Based on the health belief model, the theory of reasoned action, and the technology acceptance model, health beliefs and behavioral intention are suggested as possible explanations. A total of 498 Chinese and 292 American college students were recruited to complete an online …

Oral History Transcript | Interview With Timothy Mcfate, February 21, 2021, Timothy Mcfate, Andrew Martinez, Risd Archives, Andrew Martinez

RISD Oral History Project Transcripts

No abstract provided.

Oral History Transcript | Interview With Liisa Silander, February 21, 2021, Liisa Silander, Jennefer Liese, Risd Archives

RISD Oral History Project Transcripts

No abstract provided.

Case 70: Hemoglobin Mito: A Japanese Hemoglobin Variant With Altered Oxygen Binding Affinity, Dr. Kathleen Cornely

Chemistry & Biochemistry Case Studies

In this case study, researchers use their knowledge of hemoglobin structure to predict the oxygen binding properties of a hemoglobin mutant with a single amino acid substitution, then test their hypothesis by studying the mutant’s oxygen binding properties.

Interactive Effects Of Omega-3 Polyunsaturated Fatty Acids And Secondhand Smoke In Mice And Human Subjects, Emily Wheeler, Mary Walsh-Wilcox, Meer Shah, Abinash Achrekar, Joe R. Anderson, Mary K. Walker

Research and Scholarship

Active smoking and secondhand smoke (SHS) exposure increase the risk of cardiovascular morbidity and mortality. Active smoking is associated with reduced levels of omega-3 polyunsaturated fatty acids (n-3 PUFA) and studies show that n-3 PUFA supplementation can improve smoking-induced vascular dysfunction. However, the relationship between n-3 PUFA and SHS exposure has not been studied. Fat-1 transgenic mice, which convert n-6 to n-3 PUFA, were fed diets with n-3 PUFA or without (n-6 PUFA diet), exposed to air or SHS for 4 weeks, and vasoreactivity, antioxidant indices, and omega-3 index (percent eicosapentaenoic+docosahexaenoic acids in RBC) measured. Compared to air-exposed mice, SHS …

Physiological Consequences Of Neuromodulation And The Cellular Properties That Underlie Them, Margaret Louise Demaegd

Theses and Dissertations

Neuronal activity is a product of more than the underlying neuronal connections. Modulatory influences like changes in the animal’s environment, the animals physiological state, or the release of neuromodulators can dramatically alter neuronal activity. Modulatory influences can be beneficial for the animal because they are a source of neuronal and behavioral plasticity, and they can provide neuronal circuits with the robustness needed to continue to function in new conditions, states, or tasks.However, malfunctions of the modulatory system can disrupt neuronal activity and lead to pathologies. Predicting how modulatory influences will alter neuronal activity is challenging because the underlying cellular and …

The Pencil Code, A Modular Mpi Code For Partial Differential Equations And Particles: Multipurpose And Multiuser-Maintained, The Pencil Code Collaboration, Chao-Chin Yang

Physics & Astronomy Faculty Research

The Pencil Code is a highly modular physics-oriented simulation code that can be adapted to a wide range of applications. It is primarily designed to solve partial differential equations (PDEs) of compressible hydrodynamics and has lots of add-ons ranging from astrophysical magnetohydrodynamics (MHD) (A. Brandenburg & Dobler, 2010) to meteorological cloud microphysics (Li et al., 2017) and engineering applications in combustion (Babkovskaia et al., 2011). Nevertheless, the framework is general and can also be applied to situations not related to hydrodynamics or even PDEs, for example when just the message passing interface or input/output strategies of the code are to …

Changes At A Critical Branchpoint In The Anthocyanin Biosynthetic Pathway Underlie The Blue To Orange Flower Color Transition In Lysimachia Arvensis, Mercedes Sánchez-Cabrera, Francisco Javier Jiménez-López, Eduardo Narbona, Montserrat Arista, Pedro L. Ortiz, Francisco J. Romero-Campero, Karolis Ramanauskas, Boris Igić, Amelia A. Fuller, Justen B. Whittall

Chemistry and Biochemistry

Anthocyanins are the primary pigments contributing to the variety of flower colors among angiosperms and are considered essential for survival and reproduction. Anthocyanins are members of the flavonoids, a broader class of secondary metabolites, of which there are numerous structural genes and regulators thereof. In western European populations of Lysimachia arvensis, there are blue- and orange-petaled individuals. The proportion of blue-flowered plants increases with temperature and daylength yet decreases with precipitation. Here, we performed a transcriptome analysis to characterize the coding sequences of a large group of flavonoid biosynthetic genes, examine their expression and compare our results to flavonoid biochemical …

Explanatory Memorandum, Proposed Statements On Quality Management Standards -- Quality Management -- A Firm's System Of Quality Management Engagement Quality Reviews; Proposed Statement On Auditing Standards, Quality Management For An Engagement Conducted In Accordance With Generally Accepted Auditing Standards; Exposure Draft (American Institute Of Certified Public Accountants), 2021, February 4, American Institute Of Certified Public Accountants. Auditing Standards Board

Exposure Drafts, Comment Letters, and Statements of Position

No abstract provided.

Ripple Effects: How In Re Ripple Labs Inc. Litigation Could Signal The Beginning Of The End Of The Payment Platform, Lindsay Martin

Duke Law & Technology Review

Ripple Labs provides an international payment network that allows financial institutions to transfer money more cheaply and quickly than traditional international payments. Ripple’s native digital currency, XRP, supports global payments by acting as intermediate currency between different currencies, eliminating correspondent bank’s need to hold deposits in foreign currencies. In an ongoing class action lawsuit, XRP purchasers claim that the digital asset qualifies as a security under federal securities laws and that Ripple illegally offered and sold XRP as an unregistered security. Given Ripple’s rising prominence as a tool for financial institutions, this pending case will impact cryptocurrency markets and international …

Sga 52 Senate 2021-02-21 Minutes, Niu Student Government Association Senate

Student Government Association Archives

No abstract provided.

Coarse-Grained Simulation Of Pegylated And Tethered Protein Devices At All Experimentally Accessible Surface Residues On Β-Lactamase For Stability Analysis And Comparison, Addison K. Smith, Mehran Sultani, Joshua Wilkerson, Brandon Timmerman, Emily Long Zhao, Bradley C. Bundy, Thomas A. Knotts

Faculty Publications

PEGylated and surface-tethered proteins are used in a variety of biotechnological applications, but traditional methods offer little control over the placement of the functionalization sites on the protein. Fortunately, recent experimental methods functionalize the protein at any location on the amino acid sequence, so the question becomes one of selecting the site that will result in the best protein function. This work shows how molecular simulation can be used to screen potential attachment sites for surface tethering or PEGylation. Previous simulation work has shown promise in this regard for a model protein, but these studies are limited to screening only …