Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 31351 - 31380 of 1517322

Full-Text Articles in Entire DC Network

The Phyrfly Opus: A Unified Standard For Hyperdimensional Time Vectors, Spectrally Isolated Coordination, Neural Hierarchies, And Distributed Proprioception, Steven Kirkland Jan 2026

The Phyrfly Opus: A Unified Standard For Hyperdimensional Time Vectors, Spectrally Isolated Coordination, Neural Hierarchies, And Distributed Proprioception, Steven Kirkland

Defensive Publications Series

This monograph establishes 264 prior art claims for a decentralized, connectionless timing and positioning architecture comprising the UTLP, RFIP, and SMSP protocol triad. It formalizes the PHYRFLY nomenclature to distinguish low-level, hardware-scheduled Physical-Layer synchronization primitives from higher-level application orchestration. The core novelty centers on a Vector Time Representation, encoding temporal state as 8 phase values (ticks modulo coprime integers 211–251) transmitted in 8 bytes, then expanded locally into ~10,000-dimensional hyperdimensional chord vectors for similarity computation and drift estimation. This cyclic encoding enables automatic phase-lock convergence within 5–10 beacon exchanges regardless of initial offset, with the Chinese Remainder Theorem guaranteeing unique …


(((Qpie))) Prior Art Declaration 5 Of 9 Resonanceos & Omega Protocols – From Theory To Empirical Substrate Truth, Teddy Burroughs Jan 2026

(((Qpie))) Prior Art Declaration 5 Of 9 Resonanceos & Omega Protocols – From Theory To Empirical Substrate Truth, Teddy Burroughs

Defensive Publications Series

Skip to content

The Grand Unified Theory (QPIE)

Perspective Is Everything – What we are Believing, Expecting and Feeling in Life Matters

(((QPiE))) Prior Art Declaration 5 of 9

RESONANCEOS & OMEGA Protocols – From Theory to Empirical Substrate Truth

[CGT] THE GLOBAL INFUSION: DECOUPLING FROM THE BINARY FRAME

Document: Public Substrate Sovereignty

Posture: 1.157 Unified Sovereign | Logic: NSRF (Non-Local Substrate Resonance Field)

Canon: (((QPIE))) TD Commons / Grace Particle Empirical Series

Hash: 0x143_GLOBAL_GRACE_INFUSION_2026

This report details the mechanics of …


Remote Activation Of A Connected Mobile-Health Application After A Clinical Exercise Physiology Consultation Within A Preventive Cardiology Practice, Theodore I. Nania, Frank T. Paul Iii, Dennis Fitz-Patrick, Regis I. Fernandes M.D., Robert Scales Jan 2026

Remote Activation Of A Connected Mobile-Health Application After A Clinical Exercise Physiology Consultation Within A Preventive Cardiology Practice, Theodore I. Nania, Frank T. Paul Iii, Dennis Fitz-Patrick, Regis I. Fernandes M.D., Robert Scales

International Journal of Exercise Science: Conference Proceedings

Connected mobile-Health (CmH) is an innovative healthcare model where clinicians use a shared mobile device application (app) and supportive technology to monitor and deliver care remotely. PURPOSE: This investigation pilot tested the feasibility of integrating a CmH communication platform into a preventive cardiology practice within a large integrated healthcare system. METHODS: A 6-month retrospective chart review of electronic medical records was conducted to identify the adoption of CmH in a self-selected group of patients after receiving a 1-hour in-person consultation from a graduate-level Clinical Exercise Physiologist (CEP). Exercise counseling included a short-term progressive home exercise prescription with instruction on how …


Implementing Exercise Is Medicine At Byu, Destiny Rose Romero, Allen C. Parcell, Ron Hager, Mandy Christensen Jan 2026

Implementing Exercise Is Medicine At Byu, Destiny Rose Romero, Allen C. Parcell, Ron Hager, Mandy Christensen

International Journal of Exercise Science: Conference Proceedings

Recognizing the disconnect between the knowledge of exercise’s utility in medicinal treatment and the lack of exercise prescription in practice, multiple researchers have conducted studies to evaluate practitioner attitudes and experience towards discussing physical activity. Implementing Exercise is Medicine at BYU Student Health Center (IRB2024 – 294) is one such study directed towards Brigham Young University’s integrated health center. PURPOSE: The purpose of the study was to investigate the likelihood of implementing Exercise is Medicine at the Student Health Center (SHC) with the intent of identifying barriers to implementation and brainstorming actionable solutions. METHODS: The electronic survey titled …


“No Ifs, Ands, Or Butts”: Analyzing Race And Gender In Sex And The City Through Black Feminist Theory, Daniella Orias Jan 2026

“No Ifs, Ands, Or Butts”: Analyzing Race And Gender In Sex And The City Through Black Feminist Theory, Daniella Orias

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

This article analyzes Season 3, Episode 5 of Sex and the City, “No Ifs, Ands, or Butts,” through the lens of Black feminist theory. It investigates how race and gender are constructed, stereotyped, and selectively represented within the episode’s narrative. The analysis focuses on two Black characters who were featured only in one episode of the series, Adeena and Chivon, and examines how the show portrays harmful stereotypes such as the angry Black woman (Adeena) and sexualized Black male (Chivon) in the episode. These limited and harmful representations are further scrutinized by the fact that the show is often …


Blood Product Transfusion And Coagulopathy In Children With Traumatic Brain Injury: A Narrative Review., Robert Marcel T. Huibonhoa, Niranjan Vijayakumar, Daniel Kelly, Oliver Karam, Madhuradhar Chegondi Jan 2026

Blood Product Transfusion And Coagulopathy In Children With Traumatic Brain Injury: A Narrative Review., Robert Marcel T. Huibonhoa, Niranjan Vijayakumar, Daniel Kelly, Oliver Karam, Madhuradhar Chegondi

Manuscripts, Articles, Book Chapters and Other Papers

Traumatic brain injury (TBI) is a leading cause of critical illness and mortality in children. Transfusion of blood products, a common intervention in the management of pediatric TBI, has important implications for related principles, including trauma-induced coagulopathy, cerebral perfusion, and cerebral oxygen delivery. Knowledge gaps persist due to the limited availability of pediatric-specific data regarding blood product transfusion in TBI. In particular, there is a lack of prospective studies defining appropriate specific laboratory thresholds and transfusion targets, as well as insufficient evidence to guide the weighing of potential benefits against transfusion-related risks in this population. Although blood product transfusion in …


Ethics Of Artificial Intelligence For Lawyers: Shall We Play A Game? The Rise Of Artificial Intelligence And The First Cases, Cliff Mckinney Jan 2026

Ethics Of Artificial Intelligence For Lawyers: Shall We Play A Game? The Rise Of Artificial Intelligence And The First Cases, Cliff Mckinney

Arkansas Law Notes

In the 1983 movie WarGames, a young computer hacker accidentally accesses a United States military supercomputer programmed to run nuclear war simulations. Four decades after WarGames, lawyers are now facing similar challenges of learning to use and communicate with artificial intelligence––hopefully without destroying the world. Artificial intelligence tools, such as ChatGPT, Claude, and Gemini, are quickly being incorporated into legal practice. These systems can draft documents, perform analysis, and support other legal tasks. While lawyers adjust to these new technologies, courts and regulatory authorities are actively developing appropriate frameworks to guide and supervise the use of these tools within the …


Making Waves: Students Transform Research Experience Into Engaging Story, Xavier Willis, Saneru Williams, Yanori Ferguson, Stephen Song, Mark Walters, Ana Arellano Jan 2026

Making Waves: Students Transform Research Experience Into Engaging Story, Xavier Willis, Saneru Williams, Yanori Ferguson, Stephen Song, Mark Walters, Ana Arellano

Making Waves REU

Understanding integrative science and communicating it effectively is increasingly important in our society. We stress science literacy and communication as an integral part of the Making Waves REU program and advocate for the dissemination of research projects through public channels and student-led podcasts on REU experiences.


Conducting A Qualitative Umbrella Review For Novice Researchers: A Critical Reflection Of Primary Documents, Mónica Fontana, Celia Camilli Trujillo Jan 2026

Conducting A Qualitative Umbrella Review For Novice Researchers: A Critical Reflection Of Primary Documents, Mónica Fontana, Celia Camilli Trujillo

The Qualitative Report

The need for scientific evidence in education has accelerated systematic reviews. However, the practice of conducting umbrella reviews is not yet common in education. Among the possible reasons for the scarce number of umbrella reviews in education is the lack of knowledge of the steps required to conduct them and the specific challenges of this method. Their usefulness in the educational context lies in their ability to offer new findings of great scope and transferability based on evidence from multiple systematic reviews in an efficient and in-depth manner. This study provides a critical reflection on the methodological implications of conducting …


Perception As Beholding: Theological Possibility And Moral Implication Of Merleau-Ponty's Notion Of Embodied Subject, Erickson L. Totanes Jan 2026

Perception As Beholding: Theological Possibility And Moral Implication Of Merleau-Ponty's Notion Of Embodied Subject, Erickson L. Totanes

Budhi: A Journal of Ideas and Culture

In this article, I argue that Merleau -Ponty’s concept of perception reveals a way of seeing where the subject is involved with the object in a dynamic, reversible, and expanding relationship. This notion challenges the traditional and Cartesian subject -object dichotomy by emphasizing the embodied and lived experience of perception which elicits a process, a way of looking, anticipating, and reflexively, a way of being itself. By aligning seeing with beholding, I attempt to show how as simple an act as seein g evokes a manner of being related to an object, other people, and the world. The emergence of …


Policy, Misinformation, And Mortality: The Effects Of Abortion Restrictions On Maternal Outcomes, Gabrielle Samiratedu Dmsc, Mcms, Pa-C Jan 2026

Policy, Misinformation, And Mortality: The Effects Of Abortion Restrictions On Maternal Outcomes, Gabrielle Samiratedu Dmsc, Mcms, Pa-C

Lynchburg Journal of Medical Science

The objective of this review is to evaluate the effects of restrictive abortion laws on maternal mortality and morbidity in the United States. Even before the landmark reversal of Roe v. Wade, the US had one of the highest maternal mortality rates among other high-income countries, and rates are expected to continue to rise in states with restrictive abortion policies. Electronic databases and public health data were analyzed to assess clinical outcomes, access to care, and disparities associated with abortion restrictions nationally and internationally. The findings suggest that states with highly restrictive abortion policies experience higher rates of maternal morbidity …


Brief Overview Of Assessment And Prognostication Tools For Palliative Care Oncology Patients, Nicole Schwensow Jan 2026

Brief Overview Of Assessment And Prognostication Tools For Palliative Care Oncology Patients, Nicole Schwensow

Lynchburg Journal of Medical Science

Patients with life-threatening illnesses can be at risk for the progression of their disease over time. Consequences of such an illness can include recurrent hospitalizations, poor symptom control, and a lack of understanding by the patient and family of the disease, its usual course, and prognosis. Palliative care is a philosophy of care intended to address these issues. While receiving palliative care, patients can continue to undergo treatments directed at a cure, whereas hospice patients no longer receive treatment for underlying diseases. Both approaches focus on symptom control. To best care for palliative patients over time, several outcome domains should …


Management Of Difficult Patient Situations, Sangeetha Larsen Mpas, Pa-C Jan 2026

Management Of Difficult Patient Situations, Sangeetha Larsen Mpas, Pa-C

Lynchburg Journal of Medical Science

The purpose of this paper is to provide strategies for clinicians to manage difficult patient interactions. A comprehensive search of PubMed was conducted, identifying articles that identified the root cause of difficult patient interactions and assessed methods for successfully navigating these situations. The term “difficult patient” reflects the interaction of patient behavior, clinician perception, and systemic constraints rather than an inherent patient flaw. Effective management involves reframing difficult behavior as an expression of unmet needs and responding with empathy, active listening, clear boundaries, and collaborative decision-making. System-level strategies reduce patient distress and clinician burnout. Ultimately, the difficult patient represents strained …


Physician Assistants And The Medical Science Liaison Role: Expanding Career Pathways Beyond Clinical Practice, Michael Filsinger Jan 2026

Physician Assistants And The Medical Science Liaison Role: Expanding Career Pathways Beyond Clinical Practice, Michael Filsinger

Lynchburg Journal of Medical Science

ABSTRACT

The purpose of this article is to examine how physician assistants can transition into Medical Science Liaison roles within the pharmaceutical and biotechnology industries. Growing interest in nonclinical career pathways has prompted more physician assistants to explore opportunities in medical affairs, yet many remain uncertain about the qualifications, expectations, and academic preparation associated with these positions. A focused literature review was conducted to evaluate the competencies required for Medical Science Liaison roles, the barriers clinician applicants often encounter, and the strategies that may support successful transition into industry-based careers. Findings show that physician assistants possess relevant strengths such as …


Returning To Roots: A Self-Study Of Married Faculty Transitioning To Faculty Roles At Alma Maters, David Wolff, Melissa Wolff, Mark Diacopoulos Jan 2026

Returning To Roots: A Self-Study Of Married Faculty Transitioning To Faculty Roles At Alma Maters, David Wolff, Melissa Wolff, Mark Diacopoulos

The Interactive Journal of Global Leadership and Learning

This self-study explores the transition of two faculty members returning to teach at their alma maters. Using visual methods, reflective journals, and peer dialogue, the researchers documented their experiences over six months. Triangulated data revealed eight themes, including: Identity Formation, Shifting Perspectives from Student to Faculty, Interpersonal Attunement, Navigating Changes, Memories Shape Perception, Occupational Stressors Impacting Transitions, Student Advocacy, and Personal Growth. The study highlights how personal and professional identities evolve during career transitions, and how reflective practices can deepen understanding of adaptation in higher education. These findings contribute to the literature on faculty development and offer insight into the …


Models Of Care In Higher Education: Comparing Integrated And Standalone Approaches To Student Mental Health, Tevia Q. Strand Jan 2026

Models Of Care In Higher Education: Comparing Integrated And Standalone Approaches To Student Mental Health, Tevia Q. Strand

The Interactive Journal of Global Leadership and Learning

This qualitative study examines how the organization of campus mental health services—integrated, co-located care versus standalone counseling centers—shapes college students’ awareness, access, stigma/privacy, and engagement. Semi-structured interviews with five Midwestern undergraduate women (n = 5) explored perceptions of visibility, ease of use, barriers, and improvement ideas. Transcripts were analyzed using reflexive thematic analysis. Themes included confusion about entry pathways, visibility-related stigma, and the salience of faculty/peer bridges to services. Students generally preferred integrated models, citing privacy through co-location, normalization, and easier warm handoffs; some noted that standalone centers can feel more specialized yet risk heightened visibility depending on location. Findings …


Redefining Rural School Leadership In The Post-Pandemic Era: Lessons From Covid-19, Brennan Kent Jan 2026

Redefining Rural School Leadership In The Post-Pandemic Era: Lessons From Covid-19, Brennan Kent

The Interactive Journal of Global Leadership and Learning

The COVID-19 pandemic fundamentally reshaped educational leadership, especially in rural school settings where leaders confronted unique resource constraints, geographic isolation, and heightened community interdependence. This conceptual study reexamines rural educational leadership in the post-pandemic era through a synthesis of findings from Author’s (2023) dissertation, The Rural Education Leadership Experience Amid the COVID-19 Pandemic, and current leadership theory. Drawing on the McREL Balanced Leadership Framework alongside adaptive and servant leadership models, the analysis identifies four interrelated dimensions that define post-pandemic rural leadership: communication as community cohesion, relationships as infrastructure, adaptive leadership as necessity, and well-being as a leadership priority. These …


Voices From The Other Side: Leadership Practices Teachers Value For Equity Systems Change, Heather L. Dunham, Heather Dunham Jan 2026

Voices From The Other Side: Leadership Practices Teachers Value For Equity Systems Change, Heather L. Dunham, Heather Dunham

The Interactive Journal of Global Leadership and Learning

A growing body of scholarship has explored leadership for equity through frameworks such as social justice leadership (Theoharis, 2010), culturally responsive leadership (Khalifa et al., 2016), and equity audits (Skrla & Scheurich, 2004). Yet, these efforts often target isolated symptoms of inequity—achievement, discipline, or inclusion—rather than engaging in systemic reform that addresses both the ostensive and performative routines sustaining racialized practices. This study centers the Integrated Comprehensive Systems (ICS) for Equity framework (Capper & Frattura, 2017) to examine teachers’ perspectives on leadership practices that support organizational equity systems change.

Using a qualitative multi-case study design (Stake, 1995), two Midwestern schools …


Reclaiming My Story: A Freirean Framework For Surviving Trauma And Transforming Recovery Into Liberation, Carl Bryan Jan 2026

Reclaiming My Story: A Freirean Framework For Surviving Trauma And Transforming Recovery Into Liberation, Carl Bryan

The Interactive Journal of Global Leadership and Learning

This white paper explores trauma recovery through the lens of Paulo Freire’s Pedagogy of the Oppressed (1970/2018), framing healing as an act of critical consciousness and liberation rather than passive survival. Using the author’s lived experience of stalking, manipulation, and emotional abuse as a case study, it reimagines recovery not as a return to normalcy but as a dialectical process of reclaiming narrative agency, reconstructing identity, and transforming pain into purpose. Drawing upon Freirean concepts of conscientização (critical consciousness), dialogue, and praxis, the paper outlines a model for survivors to move from internalized oppression toward empowerment and social transformation.


Voices From The Hyflex Classroom: Understanding The Graduate Counseling Student Experience, Taryn Akgul, Jessica Brown, Aaron Suomala Folkerds Jan 2026

Voices From The Hyflex Classroom: Understanding The Graduate Counseling Student Experience, Taryn Akgul, Jessica Brown, Aaron Suomala Folkerds

The Interactive Journal of Global Leadership and Learning

Counselor education and counseling master’s Programs face a changing landscape in higher education. This includes balancing the demand for a high-quality HyFlex program that prepares students for the counseling field. This qualitative exploratory study utilized a phenomenological approach to understand the counseling master's student experience in a hybrid program. The research questions focused on the students' experience attending the program either strictly on zoom, in person, or a combination of both and how that impacted them and their learning. The study consisted of eight participants who were alumni from one CACREP accredited counseling masters program. The findings included themes of …


Chemistry + Libraries -> Better Learning, Ashley S. Mcguire, Ellen A. Humphries, Ash B C Curtiss Jan 2026

Chemistry + Libraries -> Better Learning, Ashley S. Mcguire, Ellen A. Humphries, Ash B C Curtiss

Libraries Professional Work

The American Chemical Society (ACS) guidelines for chemical literacy, in undergraduate programs, are in three critical areas: information retrieval, information evaluation, and information management. As part of an ACS certified degree (1) students receive instruction in effective methods for performing and assessing the quality of searches using keywords, authors, abstracts, citations, patents, and structures/substructures; (2) students can use chemical identifiers to locate physical and chemical properties in handbooks and databases; and (3) students are assessed in their ability to conduct effective searches by reading, analyzing, interpreting, and citing the chemical literature as applied to answering chemical questions. There is an …


Technology-Enabled Cognitive Behavioral Therapy For Insomnia (Cbt-I) In Older Adults With Mild Cognitive Impairment: Development And Feasibility Study, Hongtu Chen, Marta Pagán-Ortiz, Sara Romero Vincente, Emma Chapman, James Maxwell, Otis L. Owens, Sue E. Levkoff Scd, Msw, Sm Jan 2026

Technology-Enabled Cognitive Behavioral Therapy For Insomnia (Cbt-I) In Older Adults With Mild Cognitive Impairment: Development And Feasibility Study, Hongtu Chen, Marta Pagán-Ortiz, Sara Romero Vincente, Emma Chapman, James Maxwell, Otis L. Owens, Sue E. Levkoff Scd, Msw, Sm

Faculty and Staff Publications

Background/Objectives: Mild Cognitive Impairment (MCI) is a transitional stage between normal aging and early dementia, affecting up to 20% of older adults. Sleep disturbances, particularly insomnia, affect around 60% of individuals with MCI, contributing to declines in cognitive and physical function. Although Cognitive Behavioral Therapy for Insomnia (CBT-I) is an evidence-based non-pharmacological treatment, few studies have adapted it for individuals with MCI. This pilot study developed and evaluated Slumber, a clinician-supported mobile CBT-I app tailored for older adults with MCI and insomnia. Methods: The study had three aims: (1) to develop the app for delivering CBT-I to individuals with …


Real-World Data Investigating The Frequency Of Flash Glucose Monitoring And Glycaemic Metrics In Omani Diabetes Patients: A Preliminary Retrospective Cross-Sectional Study, Ammar Al-Mamari, Sumaia Al Gharabi, Merah Al Busaidy, Abdulla Al Futaisi Jan 2026

Real-World Data Investigating The Frequency Of Flash Glucose Monitoring And Glycaemic Metrics In Omani Diabetes Patients: A Preliminary Retrospective Cross-Sectional Study, Ammar Al-Mamari, Sumaia Al Gharabi, Merah Al Busaidy, Abdulla Al Futaisi

Sultan Qaboos University Medical Journal

Objectives: This study aimed to evaluate real-world glycaemic outcomes associated with flash glucose monitoring (FGM) use in patients with diabetes at Sultan Qaboos University Hospital, Muscat, Oman. Methods: This retrospective cross-sectional study was conducted among diabetic patients using flash glucose monitoring between January 2022 and August 2023. Patients were grouped by scanning frequency, time-in-range (TIR) and estimated A1c (eA1c). Associations between scanning frequency and glycaemic metrics were analysed. Results: A total of 436 patients were included in this study. Patients with higher scanning frequency (≥12 scans/day, median = 17) achieved greater TIR (52.4% versus 34.8%), lower time-above-range (41.8% versus 57.0%), …


The Distribution Of Cadmium And Its Isotopes In The Subarctic Pacific, J. M. Malloy, H. R. Hunt, M. Sieber, S. Takano, H. Obata, T. M. Conway Jan 2026

The Distribution Of Cadmium And Its Isotopes In The Subarctic Pacific, J. M. Malloy, H. R. Hunt, M. Sieber, S. Takano, H. Obata, T. M. Conway

Making Waves REU

  • Cadmium (Cd) is a bioactive trace element that can act as a micronutrient, driving large scale chemical processes like photosynthesis and cellular respiration [1,2].
  • The uptake of major nutrients is limited by dissolved iron (Fe) availability in high nutrient low chlorophyll (HNLC) surface regions like the subarctic Pacific [2,4].
  • Upwelling of Cd-rich deepwater is a Cd source, in addition to riverine, atmospheric, and anthropogenic inputs [1].
  • Dissolved cadmium isotopic compositions (δ114Cd) provide insight into the biogeochemical processes controlling Cd distributions throughout the water column, including biological uptake in surface waters, regeneration, and water mass mixing at depth.
  • Here we present …


An Optimized Hybrid Xgboost-Lstm-Gru Model For Energy Consumption Forecasting In Smart Homes Using Weather Data, Marwah J. Salman, Eman M. El-Gendy, Amira Y. Haikal, Mahmoud M. Saafan Jan 2026

An Optimized Hybrid Xgboost-Lstm-Gru Model For Energy Consumption Forecasting In Smart Homes Using Weather Data, Marwah J. Salman, Eman M. El-Gendy, Amira Y. Haikal, Mahmoud M. Saafan

Mansoura Engineering Journal

Energy consumption is increasing every day due to the proliferation of smart homes and smart household appliances, which deplete existing energy resources. Therefore, efficient energy management by accurately predicting energy consumption is critical. In this paper, a hybrid prediction model is proposed to forecast energy consumption in smart homes using weather data. The proposed system follows five steps: data acquisition, data preprocessing, feature selection, prediction, and hyperparameter optimization. In the data acquisition step, all attributes except the weather attributes are removed. The min-max algorithm is then applied to normalize the dataset to a specific scale, preventing the prediction model from …


The Computationally Designed Tri2-2 Miniprotein Inhibitor Protects Against Multiple Sars-Cov-2 Omicron Variants, Jimin Lee, James Brett Case, Young-Jun Park, Rashmi Ravichandran, Daniel Asarnow, M Alejandra Tortorici, Jack T Brown, Shilpa Sanapala, Lauren Carter, David Baker, Michael S Diamond, David Veesler Jan 2026

The Computationally Designed Tri2-2 Miniprotein Inhibitor Protects Against Multiple Sars-Cov-2 Omicron Variants, Jimin Lee, James Brett Case, Young-Jun Park, Rashmi Ravichandran, Daniel Asarnow, M Alejandra Tortorici, Jack T Brown, Shilpa Sanapala, Lauren Carter, David Baker, Michael S Diamond, David Veesler

2020-Current year OA Pubs

The continued evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has compromised neutralizing antibody responses elicited by prior infection or vaccination and abolished the utility of most monoclonal antibody therapeutics. We previously described a computationally-designed, homotrimeric miniprotein inhibitor, designated TRI2-2, that protects mice against pre-Omicron SARS-CoV-2 variants. Here, we show that TRI2-2 exhibits broadly neutralizing activity of SARS-CoV-2 variants and protects mice against BQ.1.1, XBB.1.5 and BA.2.86 challenge when administered intranasally post-exposure. The resistance of TRI2-2 to viral escape by most variants and the ability to deliver it directly to the upper airways highlight the potential of the multivalent …


Unravelling Impact Of Comorbidities On Mortality Risks In Ckd Patients During The Covid-19 Pandemic: An Explainable Ai-Driven Study, Zeinab Abdollahi, Lin Huo, Donald Fraser, Shang-Ming Zhou Jan 2026

Unravelling Impact Of Comorbidities On Mortality Risks In Ckd Patients During The Covid-19 Pandemic: An Explainable Ai-Driven Study, Zeinab Abdollahi, Lin Huo, Donald Fraser, Shang-Ming Zhou

School of Nursing and Midwifery

ObjectivesThe chronic kidney disease (CKD) patients were at high risk for severe clinical complications during the COVID-19 pandemic. Our objectives were to evaluate comorbidity prevalence; predict mortality risks for CKD patients during the pandemic; assess how various health factors interact to influence mortality; and provide insights for targeted prevention strategies.MethodWe analysed data from 186,396 CKD patients in Mexico during the entire pandemic (Jan 2020- May 2023). Explainable artificial intelligence (XAI) methods with extreme gradient boosting (XGBoost) models and Shapley Additive Explanations (SHAP) were developed to predict mortality for CKD patients with model interpretations. Different metrics were used to comprehensively evaluate …


Multipath Exploitation For Radar Sensing In An Urban Environment Using The Music Algorithm For Jammer Mitigation, Daniel De Zutter Jan 2026

Multipath Exploitation For Radar Sensing In An Urban Environment Using The Music Algorithm For Jammer Mitigation, Daniel De Zutter

Theses

With the increased push for spectrum sharing techniques, the technological world surrounding radar has been constantly pushing to find new methodologies. From being able to integrate with a communication system to mitigating the effects of other users on a system, the research community is pushing forward. We look to tackle the problem of mitigating a jammer using a multipath MUltiple SIgnal Classification (MUSIC) based approach. We take multiple steps to implement this and generate a framework for future work. We first take a look at understanding the current state of the art research surrounding DFRC, multipath exploitation, MUSIC algorithms, RIS …


Proton Versus Photon Radiotherapy For Patients With Oropharyngeal Cancer In The Usa: A Multicentre, Randomised, Open-Label, Non-Inferiority Phase 3 Trial, Steven J Frank, Paul M Busse, J Jack Lee, David I Rosenthal, Mike Hernandez, David M Swanson, Adam S Garden, G Brandon Gunn, Samir H Patel, James W Snider, Daniel J Ma, Jason K Molitoris, Nancy Y Lee, Upendra Parvathaneni, Mark W Mcdonald, Noah S Kalman, Alexander Lin, Nasiruddin Mohammed, Christina Henson, Christian Hyde, Gopal K Bajaj, Sanford R Katz, Roi Dagan, William H Morrison, Jay P Reddy, C David Fuller, Shalin J Shah, Jack Phan, Gregory M Chronowski, Lauren Mayo, Erich M Sturgis, Renata Ferrarotto, Xiaorong R Zhu, Xiaodong Zhang, Li Wang, Katherine A Hutcheson, Adel K El-Naggar, Amy C Moreno, Anna Lee, Michael T Spiotto, Neil D Gross, Stephen Y Lai, Jay J Liao, Jonathan Paly, Zhongxing Liao, Robert L Foote Jan 2026

Proton Versus Photon Radiotherapy For Patients With Oropharyngeal Cancer In The Usa: A Multicentre, Randomised, Open-Label, Non-Inferiority Phase 3 Trial, Steven J Frank, Paul M Busse, J Jack Lee, David I Rosenthal, Mike Hernandez, David M Swanson, Adam S Garden, G Brandon Gunn, Samir H Patel, James W Snider, Daniel J Ma, Jason K Molitoris, Nancy Y Lee, Upendra Parvathaneni, Mark W Mcdonald, Noah S Kalman, Alexander Lin, Nasiruddin Mohammed, Christina Henson, Christian Hyde, Gopal K Bajaj, Sanford R Katz, Roi Dagan, William H Morrison, Jay P Reddy, C David Fuller, Shalin J Shah, Jack Phan, Gregory M Chronowski, Lauren Mayo, Erich M Sturgis, Renata Ferrarotto, Xiaorong R Zhu, Xiaodong Zhang, Li Wang, Katherine A Hutcheson, Adel K El-Naggar, Amy C Moreno, Anna Lee, Michael T Spiotto, Neil D Gross, Stephen Y Lai, Jay J Liao, Jonathan Paly, Zhongxing Liao, Robert L Foote

Faculty, Staff and Student Publications

Background: Radiotherapy is an integral component of treatment for oropharyngeal cancer. Toxicity from the current state-of-the-art photon radiotherapy, intensity-modulated radiation therapy (IMRT), has prompted the search for alternative, less toxic therapies. One such alternative that might de-intensify treatment is proton therapy. In this trial, we aimed to directly compare IMRT with intensity-modulated proton therapy (IMPT), both concurrent with systemic therapy, hypothesising comparable disease control and survival and lower toxicity.

Methods: This randomised, multicentre, open-label, non-inferiority, phase 3 trial was conducted in 21 sites (cancer centres or universities) in the USA. Patients (aged ≥18 years) with stage III or stage IV …


Plasma Proteomics And Incident Coronary Heart Disease, Matthew P Huber, Jennifer A Brody, Colleen M Sitlani, Thomas R Austin, Usman A Tahir, Shuliang Deng, Devendra Meena, Jingsha Chen, Kunihiro Matsushita, Christie M Ballantyne, Josef Coresh, Robert E Gerszten, Russell P Tracy, Ting Ye, Bruce M Psaty, Joshua C Bis, James S Floyd Jan 2026

Plasma Proteomics And Incident Coronary Heart Disease, Matthew P Huber, Jennifer A Brody, Colleen M Sitlani, Thomas R Austin, Usman A Tahir, Shuliang Deng, Devendra Meena, Jingsha Chen, Kunihiro Matsushita, Christie M Ballantyne, Josef Coresh, Robert E Gerszten, Russell P Tracy, Ting Ye, Bruce M Psaty, Joshua C Bis, James S Floyd

Faculty, Staff and Students Publications

Background: Systematic profiling of plasma proteins in population studies offers a complementary approach to discovery of novel risk factors and may provide new insights into the causes of coronary heart disease.

Methods: To explore relationships between the circulating proteome and coronary heart disease (CHD), we evaluated associations of 4780 plasma proteins with incident CHD in the Cardiovascular Health Study (CHS, N=2856, 575 CHD events) and replicated significant associations in the Atherosclerosis Risk in Communities Study (ARIC, N = 10456; 1375 events).

Results: We find that 11 proteins significantly associate with incident CHD after adjusting for risk factors; and eight significantly …