Digital Commons Network^™

Comparative Evolution Of Caenorhabditis Hermaphrodites, James Francis Kennedy

Theses and Dissertations

The Caenorhabditis genus produced three independently-evolved hermaphroditic species, C. elegans, C. briggsae, and C. tropicalis. This convergence happened by the independent co-option of male programs for use in a female body. This required two distinct steps: (1) mutations in the sex-determination pathway that activated spermatogenesis in XX animals, and (2) mutations that expressed one of the redundant sperm activation signals in XX animals. My project focused on characterizing how sex-determination genes work in C. briggsae and C. tropicalis. Loss-of-function alleles were used to compare the core sex-determination pathway to that of C. elegans. I found that the somatic sex-determination pathway …

Densest Subgraph Discovery On The Cpu, Hunter Gerard Gareau

Theses and Dissertations

The Densest Subgraph Discovery (DSD) problem is a prevalent problem in the field of graph mining, aiming to find the cohesive subgraph. Given a graph �� = (��,��) and an integer �� ≥ 2, the goal is to find a vertex sub- set �� ⊆ �� whose induced subgraph �� (��) maximizes the ��-clique density, defined as the number of ��-cliques per vertex. Larger val- ues of �� capture higher-order connectivity patterns beyond edges, enabling the discovery of more cohesive structures. There have been many solutions to this problem. However, one avenue that other graph mining problems have gone down …

A Human-Centric Framework: Employment Principles For Lethal Autonomous Weapons, Brennan Deveraux

Books, Monographs & Collaborative Studies

This monograph challenges the Department of War to reframe the conversation about humans’ involvement in lethal autonomous weapons systems by codifying a human-centric framework built on the employment pillars of certification, authority, restriction, and accountability. Although an ample body of literature discusses lethal autonomous weapon systems, this monograph takes a novel approach by proposing a theoretical framework and applying it to historical and hypothetical practical scenarios involving weapons with autonomous characteristics. In terms of methodology, the monograph relies heavily on primary sources, including UN documents and Department of War publications, which are augmented by secondary sources from experts in the …

High School Dropout Rates Among Latin Students In The United States, Taryn T. Marriott

Student Works

An ongoing concern of educators and community members is the disproportionately high amounts of Latinx students dropping out of high school in the United States. Although there has been notable research done and action taken, the problem still remains. Lack of familial support, discrimination, and residence in low-income areas all contribute to the low retention rates of Latinx youth on track to graduate high school. As a result, youth who do not complete their education and set their sights on career goals have a harder time with employment, communicating in their society, and tend to show higher levels of engagement …

Clinical Practice Guideline: Self-Care Management For Patients With Chronic Obstructive Pulmonary Disease (Copd), Scholastica Nnedimma Ihejirika

Walden Dissertations and Doctoral Studies

Summary The DNP project is a clinical practice guideline (CPG) quality improvement project to guide nurses in caring for patients admitted with chronic obstructive disease (COPD). The quality issue identified was an increased readmission rate for patients with COPD in the facility, of which knowledge and awareness remain extremely low. An annual target of 19.36% was set by the facility to track the readmission rate of patients with COPD, and according to statistics from the facility, from July 2021 to June 2022, the rate was 25.7%; from July 2022 to June 2023, the readmission rate increased to 26%, thus necessitating …

Delegation And Agency Deference In Financial Regulation: A Comparative Eu-U.S. Perspective, Rosa M. Lastra, Patricia A. Mccoy

Law and Contemporary Problems

No abstract provided.

Systemic Risk And Macroprudential Regulation, Seraina Grünewald, Jeremy Kress

Law and Contemporary Problems

No abstract provided.

An Ocean Apart: The Regulation Of Financial Technology In The United States And European Union, Dan Awrey, Pauline Pailler

Law and Contemporary Problems

No abstract provided.

The Divergence Of Mandatory Climate Disclosure In The United States And European Union, Alessio M. Pacces, David Zaring

Law and Contemporary Problems

No abstract provided.

Sustainability Assurance, Luca Enriques, Alessandro Romano, Andrew F. Tuch

Law and Contemporary Problems

No abstract provided.

Report On A Self-Directed Pilot Study (For Students), Yoshihiko Ariizumi

Spiritual Proficiency

Level Up Your Life: The Science of Spiritual Growth

Ever feel like you're stuck in "mental noise" or struggling to stay focused? This study explores how a simple 4-week routine can literally "accelerate" your brain and emotional resilience. By using checklists and specific mental "switches," I found that we can turn daily frustrations into moments of gratitude and even boost our ability to learn complex subjects. This isn't just about faith; it's about a practical "system" to help you stay calm, sharp, and connected to your higher purpose in a busy world.

Development Of An Educational Intervention To Enhance Nurses’ Knowledge And Intent To Implement Evidence-Based Diabetes Self-Management In Clinical Practice, Anne Marie Sieyou Ngouane

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice (DNP) project was purposed with closing critical gaps in staff knowledge and adherence to diabetes self-management protocols in a busy primary care clinic. Rising readmission rates and uneven use of American Diabetes Association (ADA) standards signaled an urgent need for a structured approach to staff education. To address this, a one-hour interactive training session was created that blended teaching, evidence-based handouts, and a practical diabetes care checklist. Staff learning was measured through pretest and posttest, confidence and adherence used a 5-point Likert-scale survey, and 21day readmission data tracked patient outcomes. The project question asked if …

Enhancing Anxiety Identification In Adult Patients, Wonda Crump

Walden Dissertations and Doctoral Studies

In this Doctor of Nursing (DNP) project, I focused on implementing a staff education program for anxiety screening at a health and wellness clinic. Mental health conditions, particularly anxiety disorders, are common in primary care settings. Research shows that anxiety affects millions of adults, yet many cases remain undiagnosed. The practice problem that I identified was that many patients with anxiety disorders were going undiagnosed during regular clinic visits. The clinic had no standard process for screening anxiety, and staff members had a knowledge deficit on the proper use of anxiety assessment tools. This gap in practice led to missed …

Evaluation Of Unmet Needs Of Vulnerable Populations And At-Risk Communities Through Disaster Management Planning, Ryan Austin Crowe

Walden Dissertations and Doctoral Studies

This community-based non-profit organization aimed to aid those most in need by providing critical social services. The client organization has been selected numerous times as a recipient of federal disaster case management programs, often not until a year after the disaster, resulting in distrust of the federal government and organizations contracted to perform recovery services. Providing services to areas impacted has been difficult due to contract delays. The practice research question addressed in this study was: How can a client organization address the one-year service gap frequently associated with federal contracts through a disaster management planning system? The purpose of …

Usaid Grant Recipient Data Fy2002-2025, Susan Turner Haynes

Faculty Works

Grant recipient data from USAID from fiscal years 2002-2025.

Play-Based Curriculum, Marina E. Prawdzik

Masters Projects

This project addresses the drastic decline of play and play-based learning in public education early childhood settings. Kindergarten classrooms have shifted their focus more to academics in the form of lecture based learning and lessons, rather than play based learning techniques. Because of this, children are lacking in cognitive development, physical development and social and emotional development and growth. This project includes research from within the state of Michigan, research within the United States as a whole, and research about play based learning from other countries such as Nigeria, Mexico, South Africa, Kenya, Finland, and Germany.

Tumor-Infiltrating Bacteria Disrupt Cancer Epithelial Cell Interactions And Induce Cell-Cycle Arrest, Jorge Luis Galeano Niño, Falk Ponath, Victor A Ajisafe, Clara R Becker, Andrew G Kempchinsky, Martha A Zepeda-Rivera, Javier A Gomez, Hanrui Wu, Jessica G Terrazas, Heather Bouzek, Elizabeth Cromwell, Pritha Chanana, Matthew Wong, Ashish Damania, Michael G White, Y Nancy You, Scott Kopetz, Nadim J Ajami, Jennifer A Wargo, Christopher D Johnston, Susan Bullman

Faculty, Staff and Student Publications

Tumor-infiltrating bacteria are increasingly recognized as modulators of cancer progression and therapy resistance. We describe a mechanism by which extracellular intratumoral bacteria, including Fusobacterium, modulate cancer epithelial cell behavior. Spatial imaging and single-cell spatial transcriptomics show that these bacteria predominantly localize extracellularly within tumor microniches of colorectal and oral cancers, characterized by reduced cell density, transcriptional activity, and proliferation. In vitro, Fusobacterium nucleatum disrupts epithelial contacts, inducing G0-G1 arrest and transcriptional quiescence. This state confers 5-fluorouracil resistance and remodels the tumor microenvironment. Findings were validated by live-cell imaging, spatial profiling, mouse models, and a 52-patient colorectal cancer cohort. Transcriptomics reveals …

Spatial Omics At The Forefront: Emerging Technologies, Analytical Innovations, And Clinical Applications, Yunhe Liu, Yibo Dai, Linghua Wang

Faculty, Staff and Student Publications

Spatial omics transforms our understanding of cancer by revealing how tumor cells and the microenvironment are organized, interact, and evolve within tissues. Here, we synthesize advances in spatial technologies that map tumor ecosystems with unprecedented fidelity. We highlighted analytical breakthroughs-including multimodal integration and emerging spatial foundation models-that resolve functional niches and spatial communities, converting spatial patterns into mechanistic insights. We summarize how spatially organized features, from immune hubs to microbiota and neural interfaces, shape tumor evolution and clinical outcomes. We then outline how spatial approaches illuminate precancer biology, metastatic adaptation, and therapy response. Bridging discovery and translation, we provide a …

Adipose Stromal Cell-Derived Cancer-Associated Fibroblasts Promote Pancreatic Adenocarcinoma Progression Through Sfrp4 Signaling, Joseph Rupert, Lingyi Cai, Alexes C Daquinag, Dimitris Anastassiou, Mikhail G Kolonin

Faculty, Staff and Student Publications

Background/objectives: Progression of pancreatic ductal adenocarcinoma (PDAC) and other carcinomas relies on cancer-associated fibroblasts (CAFs). A subset of CAFs is derived from adipose stromal cells (ASCs) recruited by tumors and the ASC-CAF conversion has been associated with invasiveness and poor prognosis.

Methods: To explore the underlying molecular mechanisms, we used a model based on primary ASCs derived from human visceral adipose tissue co-cultured with human PDAC cell line Capan-1. To investigate cancer progression in vivo, we also used mice orthotopically grafted with mouse KPC cells.

Results: Genomic analysis revealed that Capan-1 co-culture induces Wnt and TGFβ signaling and extracellular matrix …

2026-01-12 Message From The President, Morehead State University. Office Of The Provost.

Staff Congress Records

Message sent on January 12, 2026 by the President to the campus community regarding upcoming dates of importance, congratulatory recognitions, and the New Carnegie Designation.

Employing Ai Tools To Predict Features For Dental Care Use In The United States During The Global Respiratory Illness Outbreak, Preeti Pushpalata Zanwar, Hamid-Reza Kodan-Ghadr, Vijayakumar Thirumalai, Suad Ghaddar, Shuo Jim Huang, Beth Harkness, Eben Rey, Romanch Shah, Sairaja Reddy Kurelli, Jay S. Patel

Health & Biomedical Sciences Faculty Publications

No abstract provided.

Lanthorn, Vol. 60, No. 09, January 12, 2026, Grand Valley State University

Volume 60, August 4, 2025 – April 20, 2026

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Message From The President, Georgia Southern University

Messages from the President

No abstract provided.

Optimal Quantization Of Finite Uniform Data On The Sphere, Mrinal Kanti Roychowdhury

School of Mathematical & Statistical Sciences Faculty Publications

This paper develops a systematic and geometric theory of optimal quantization on the unit sphere 𝕊2, focusing on finite uniform probability distributions supported on the spherical surface—rather than on lower-dimensional geodesic subsets such as circles or arcs. We first establish the existence of optimal sets of n-means and characterize them through centroidal spherical Voronoi tessellations. Three fundamental structural results are obtained. First, a cluster-purity theorem shows that when the support consists of well-separated components, each optimal Voronoi region remains confined to a single component. Second, a ring allocation (discrete water-filling) theorem provides an explicit rule describing how optimal representatives are …

Robust And High-Efficiency Demodulation Of Ultra-Weak Fbg Arrays In Ofdr-Based Distributed Sensing, Zhaopeng Zhang, Yuxuan Cao, Xu Liu, Dingcheng Wang, Bo Liu, Chen Zhu

Electrical and Computer Engineering Faculty Research & Creative Works

A robust and high-efficiency demodulation scheme for optical frequency domain reflectometry (OFDR) based ultra-weak fiber Bragg grating (UWFBG) array detection system, originating from the Buneman frequency estimation (BFE) algorithm, is proposed and experimentally demonstrated. Due to the current limitations and imperfections of FBG inscription technology, the quasi-continuous inscription approach, along with its less-than-ideal outcomes, gives rise to problems of grating spectrum splitting and spectral distortion during the grating demodulation process. This renders the traditional approach of directly applying the BFE algorithm for grating demodulation ineffective, despite its significant enhancement of demodulation efficiency. To address this issue, we propose utilizing the …

Changes In Phenology Mediate Vertebrate Population Responses To Temperature Globally, Viktoriia Radchuk, Carys V. Jones, Nina Mclean, Anne Charmantier, Céline Teplitsky, Ray Alisauskas, Sergio Ancona, Tycho Anker-Nilssen, Peter Arcese, Karl S. Berg

School of Integrative Biological & Chemical Sciences Faculty Publications

Phenotypic responses to climate affect individual fitness, but the extent to which this translates into effects on population dynamics remains poorly understood. We assemble 213 time series on phenotypes and population sizes of wild vertebrates globally and match them with local climate data. Our meta-analysis shows that morphological traits are mostly climate insensitive. However, phenology is earlier in warmer-than-average years, which contributes positively to population growth in most species. At lower latitudes, temperature has weaker effects on phenology but stronger direct negative effects on population growth, likely because these populations are less capable of tracking climate via plasticity. Variation in …

Wild@Fire2025: Overview Of Word-Level Code-Mixed Language Identification In Dravidian Languages, Ameeta Agrawal, Asha Hegde, Sharal Coelho, Sabur Butt, Fazlourrahman Balouchzahi, Sudha V, Shashirekha Hosahalli Lakshmaiah

Computer Science Faculty Publications and Presentations

Code-mixing is considered as a linguistic phenomenon that combines several languages into one text. It has now become very common in multilingual societies, especially in digital communication. Word-Level Identification of Languages in Dravidian Languages (WILD) - a Code-mixed Language Identification (CoLI) in Dravidian languages shared task, organized as a part of Forum for Information Retrieval and Evaluation (FIRE) 2025, put forward these challenges to the researchers by asking them to develop models capable of classifying words in code-mixed texts involving Dravidian languages - Tamil, Telugu, Malayalam, Kannada, and Tulu, which are interwoven with English. It poses significant challenges due to …

Chek2 Loss Endows Chemotherapy Resistance To Hematopoietic Stem Cells, Jing Zhou, Tianyuan Hu, Dian Li, Sanming Li, Minhua Li, Xiangguo Shi, Daisuke Nakada

Faculty, Staff and Students Publications

Individuals with history of chemo- or radiotherapy frequently exhibit somatic mosaicism in the blood, often involving mutations in genes responsible for DNA damage responses (DDR), such as CHEK2. However, the mechanisms by which CHEK2 mutations promote the expansion of mutant cells following chemo- or radiotherapy remain poorly understood. Here, we demonstrate that loss of CHEK2 confers resistance to chemotherapy in hematopoietic stem and progenitor cells (HSPCs). Through a CRISPR-based screen, we identified CHEK2 as a gene whose loss enhances resistance to cytotoxic chemotherapies. A complementary drug screen revealed that CHEK2-mutant cells are also resistant to DNA hypomethylating agents. Chek2-deficient HSPCs …

Notes From The Editor, Derek Stadler

Urban Library Journal

I am very pleased to welcome you to the second issue of the 31^st volume of Urban Library Journal, which is a collection of proceedings from the LACUNY Institute held on Wednesday, May 21, 2025 as a hybrid event at City College of New York. The theme of the Institute was “The Persistent Record: Preserving Knowledge in an Uncertain World.” It explored challenges faced by librarians and information professionals across our profession. Presentations delved into the preservation of politicized data, intellectual freedom, censorship, and how information professionals can navigate these challenges in an ever-changing world.

Reference-Guided Generative Augmentation Of Low-Quality Images, Ilia Labzovsky, Danny Karmon

Defensive Publications Series

Many photo archives, e.g., personal photo libraries, suffer from poor quality due to factors such as capture with older, low-resolution cameras, motion blur, etc. Such images, while possibly holding significant sentimental value, are visually unsatisfying and unsuitable for printing or for high-resolution display. This disclosure describes techniques that generatively fill in contextually accurate detail in a low-quality image. Multimodal analysis of the image is performed to detect key regions of interest (faces, objects, etc.) that are low quality (blurred, pixelated, etc.). These regions are used to retrieve relevant, high-fidelity reference images from personal and global data corpora. The resulting multimodal …