Digital Commons Network^™

Can Legal Knowledge Save Lives? A Randomized Experiment In Preventive Health Screenings, Christopher Robertson, Wendy Netter Epstein

Faculty Scholarship

While the U.S. healthcare system typically imposes significant out-of-pocket costs, the Affordable Care Act (ACA) requires full insurance coverage for certain preventive health services (PHS), including cancer screenings, without cost-sharing. Despite this policy, one in four eligible Americans remains unscreened for breast, colorectal, and cervical cancer, which increases their risk of premature death. We hypothesize that a lack of awareness about the ACA’s free care requirement contributes to this gap and that explicitly informing patients could increase screening uptake. Additionally, we investigate whether prior experiences with medical debt deter individuals from seeking even cost-free care, reflecting a spillover effect of …

Ia Et Maintien De L'Ordre : Rapport De Synthèse Des Connaissances Sur La Gouvernance Et L'Utilisation De L'Intelligence Artificielle Par La Police Au Canada, Benjamin Perrin, Geoffrey Liew, Isabelle Sweeney

All Faculty Publications

Les services de police de partout au Canada utilisent, ou explorent, un large éventail de technologies d'intelligence artificielle (IA), y compris la reconnaissance faciale, le maintien de l'ordre prédictif basé sur la localisation, les lecteurs de plaques d'immatriculation automatisés, les rapports de police assistés par IA, la reconnaissance d'objets et l'analyse vidéo, la surveillance des médias sociaux, la détection de coups de feu, le génotypage probabiliste et l'exploration de données.

Bien que promettant des avantages en matière de productivité et de sécurité publique, ces outils soulèvent également diverses préoccupations et risques. Le Canada manque actuellement de mesures législatives et de …

Spatial Profiling Reveals Distinct Molecular And Immune Evolution Of Mouse Lung Adenocarcinoma Precancers With Or Without Carcinogen Exposure, Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian-Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao-Wei Lu, Hong Chen, Chenxi Ma, Xin Hu, Jie Ye, Andrew Y Liu, Beibei Huang, Frank R Rojas, Parra Cuentas Edwin Roger, Ou Shi, Monique B Nilsson, Alissa Poteete, Khaja B Khan, Wei Lu, Luisa M Solis Soto, Junya Fujimoto, Cara Haymaker, Ignacio I Wistuba, Zhubo Wei, Linghua Wang, Don L Gibbons, Ken Chen, Alexandre Reuben, Jason M Schenkel, John V Heymach, Chao Cheng, Jia Wu, Jianjun Zhang

Faculty, Staff and Student Publications

Tumor evolution involves genetic, transcriptional, and phenotypic alterations that shape cancer cell behavior and interactions with the microenvironment. While single‐cell technologies have advanced our understanding of this process, spatial dynamics remain incompletely characterized. Here, whole‐exome sequencing (WES), imaging mass cytometry (IMC), and spatial transcriptomics (ST) were integrated to study molecular evolution and immune responses in two lung adenocarcinoma (LUAD) mouse models: a genetically engineered model (129S4/Sv‐KrasLSL‐G12D, termed 129S4 K) and a carcinogen‐induced precancer model (129S4 U). Compared to 129S4 K, 129S4 U tumors exhibited higher mutational, neoantigen but lower copy number variation (CNV) burdens at matched developmental timepoints, consistent with …

Validation Of Longitudinal Biomarker Screening Algorithms For Hcc Detection In Patients With Cirrhosis, Amit G Singal, Qingchun Jin, Jorge Marrero, Neehar D Parikh, Anna S Lok, Camden Lopez, Stephanie Page-Lester, Lewis R Roberts, Rajender Reddy, Michelle Luster, Saira Khaderi, Sumeet K Asrani, Hashem B El-Serag, Fasiha Kanwal, Ziding Feng, Nabihah Tayob

Faculty, Staff and Students Publications

Background: Blood-based biomarker panels, including GALAD, have been proposed as an alternative to abdominal ultrasound for hepatocellular carcinoma (HCC) surveillance. Studies suggest longitudinal evaluation of biomarkers can improve test performance; however, no large studies have validated these findings.

Methods: We leveraged the HCC Early Detection Strategy (HEDS) study (n=1019 patients with cirrhosis; 99 incident HCC) and Texas HCC Consortium (THCCC) (n=2345 patients with cirrhosis; 126 incident HCC) to compare the performance of fixed-threshold GALAD (cutoff of -1.36), and 4 longitudinal algorithms: longitudinal GALAD, PALAD, mFB-ALAD, and mPEB-ALAD. The HEDS cohort was used to derive longitudinal algorithms, and external validation was …

Copyrighting Nature, Cathay Y. N. Smith -- Professor Of Law

Vanderbilt Law Review

This Article introduces a "work of nature" doctrine for copyright law. In 1903, the U.S. Supreme Court established the principle in copyright law that, while anyone can copy the original source of a copyrighted work, they cannot copy an author's copy of the original source. A century later, the U.S. Court of Appeals for the Ninth Circuit hinted at a "work of nature" exception, suggesting that even if copying the copy is restricted, copying elements of expression that nature displays for all observers is permissible. U.S. patent law excludes products of nature from protection, but this Article is the first …

« À La Fois Une Fierté Et Un Vertige » : Dire Le Droit Des Personnes Et De La Filiation En Contexte De Réforme (2022-2025), Régine Tremblay

All Faculty Publications

Quelle chance d’écrire sur une réforme du Code civil du Québec pour célébrer les 50 ans du Centre Paul-André Crépeau ! Depuis l’arrivée au pouvoir de la Coalition Avenir Québec (CAQ) en 2018, le fond et la forme du droit des personnes et des familles ont été transformés. Entre 2021 et 2025, le gouvernement majoritaire de la CAQ a déposé quatre projets de loi, un chantier par étapes que le ministre de la Justice et Procureur général du Québec, M. Simon Jolin-Barette, qualifia pour sa part de « première réforme majeure »  en droit de la famille depuis 1980. Pour …

Thermodynamically Consistent Incorporation Of The Langmuir Adsorption Model Into Compressible Fluctuating Hydrodynamics, Hyun Tae Jung, Hyungjun Kim, Alejandro L. Garcia, Andrew J. Nonaka, John B. Bell, Ishan Srivastava, Changho Kim

Faculty Research, Scholarly, and Creative Activity

For a gas–solid interfacial system where chemical species undergo reversible adsorption, we develop a mesoscopic stochastic modeling method that simulates both gas-phase hydrodynamics and surface coverage dynamics by coupling the Langmuir adsorption model with compressible fluctuating hydrodynamics. To this end, we derive a thermodynamically consistent mass–energy update scheme that accounts for how the mass and energy variables in the gas and surface subsystems should be updated according to the changes in the number of molecules of each species in each subsystem due to adsorption and desorption events. By performing a stochastic analysis for the ideal Langmuir model and the full …

Ultrarenderer: Real-Time Heterogeneous Cpu-Gpu Memory Management And Adaptive View-Dependent Rendering For Massive 3d Environments, Huadong Zhang

Theses

Rendering large-scale 3D datasets in real-time presents significant challenges due to the widening gap between the ever-growing scale of dataset complexity and the limited memory capacity of modern GPUs. As datasets increasingly exceed available GPU memory, traditional methods encounter severe bottlenecks, such as restricted CPU-GPU bandwidth and inefficient memory usage, which significantly hinder rendering performance. This is especially problematic in interactive applications where high frame rates and low latency are critical. To address these limitations, this dissertation presents UltraRenderer, a novel out-of-core rendering method designed to maximize visual fidelity under strict memory and bandwidth constraints. The core of our approach …

Online Age Gating: An Interdisciplinary Evaluation, Noah Apthorpe, Brett Frischmann, Yan Shvartzshnaider

Faculty Publications

The recent surge in regulation seeking to establish age-based governance online is part of a decades-long attempt to establish online zoning. It is driven by active development of technologies to estimate or verify user age based on various characteristics of users, their credentials, or their activities. However, these developments have heightened prevailing concerns that online age gating technology will inevitably be abused and misused to cause a variety of privacy harms and rights infringements. This paper examines this ongoing debate by bridging technical and legal scholarship to explore the current state of online age-based governance. We discuss the current legal …

We Are Still In It: A Conceptual Model For Moral Injury And Burnout In Alternative Response Programs To Guide Intervention, Miranda Worthen, Soma De Bourbon, Omar Breedlove, Courtney Ewing, Joseph Graterol, Amelia Harmon, Nakia Hines, Erik Lundgren, Michael Mason, Michael Marchiselli, Vania Mendoza, Khoa Nguyen, Britt Rubin, April Sloan, Shira Maguen

Faculty Research, Scholarly, and Creative Activity

Introduction: About 20% of police calls involve a person experiencing a behavioral health crisis. To better address these community member’s needs and reduce risk of harm, jurisdictions are developing programs that shift calls for crises related to homelessness, addiction, and mental health to non-law enforcement alternatives. In responding to these calls, first responders working in these alternative response programs are exposed to a different set of moral dilemmas and pressures, increasing their risk of developing moral injury. Methods: The Alternative Response Program Moral Injury and Burnout Model highlights causes of exposure to potentially morally injurious events and the interplay between …

An Analysis Of Injury And Fatality Trends In The U.S. Construction Industry, Ryan Dutt

Construction Management

Construction work is one of the most dangerous industries in the United States, with different trades and work types showing various risk levels for injuries and fatalities. This paper’s objective is to identify the safety trends in construction over the past 10 to 20 years and understand the trades, accident types, and construction sectors with the highest safety risks. All of the data was obtained from the Occupational Safety and Health Administration (OSHA), the Bureau of Labor Statistics (BLS), the National Institute for Occupational Safety and Health (NIOSH), and the National Safety Council (NSC) databases, broken down by trade, accident …

Slo Botanical Garden Lean-To Carport, Saul Gracian, Sergio Gonzalez

Construction Management

This paper documents the planning, design, funding, and construction of a lean-to carport for the San Luis Obispo Botanical Garden, completed as a student-led Construction Management senior project by Saul Gracian and Sergio Gonzalez. The purpose of the project was to provide a functional storage structure for garden equipment while applying construction management principles in a real-world, nonprofit setting. The project methodology included site evaluation, collaborative design development, cost estimating, funding acquisition, regulatory review, and hands-on construction. Design decisions were informed by site constraints, county code requirements, budget limitations, and stakeholder input, resulting in a final 10’ x 12’ structure …

Slo Botanical Garden Outdoor Classroom, Nathan Berger, Jake Galster

Construction Management

This paper focuses on the construction and completion of outdoor benches and tabletops for the renovation of the SLO Botanical Garden’s Outdoor Classroom. This project is student lead for the completion of the Cal Poly SLO Construction Management curriculum requirement of a senior project by the project team consisting of Nathan Berger and Jake Galster. The objective of the project is to build two 12’ long benches that allow the SLO Botanical Garden staff to store four bins beneath each bench. The table tops objective to provide students in the outdoor classroom a flat and level workspace that is removable …

Case Study: The Benefits Implementing Azure 3d Printed Homes Onto Dignitymoves Project In San Luis Obispo, Lucy E. Heimer

Construction Management

California is actively addressing the challenges of housing shortages and climate change. These challenges have shifted the construction industry, steering the market into finding more sustainable means of construction. This case study evaluates the sustainable benefits of modular construction fabricated by Azure Homes. The focused project is a DignityMoves project in San Luis Obispo where modular units are factory built in El Segundo, CA and set on site. DignityMoves is a nonprofit organization that aims to provide housing for unhoused individuals throughout California. Thus far, DignityMoves has opted to use prefabricated modular units as their primary means of construction on …

From Concept To Construction: A Carport For The Slo Botanical Garden, Trent A. Denholm

Construction Management

This paper documents the design, budgeting, procurement and construction of a timber framed carport with architectural shingle roofing at the San Luis Obispo Botanical Garden (SLOBG). The Botanical Garden, a nonprofit organization dependent on community support and volunteer labor, identified the need for covered storage and a dedicated charging station for its golf cart, a vehicle central to daily operations across the property. Without permanent shelter, the cart was exposed to the elements year-round, which contributed to equipment wear and reduced operational efficiency. Working simultaneously as project manager and lead builder, Trent coordinated stakeholder relationships, developed a project budget, secured …

Drainage And Pedestrian Access Improvements At City Farms Slo, Benjamin Marc Kocher, Jacob Anthony Booker

Construction Management

This senior project focused on planning, designing, and constructing drainage and pedestrian access improvements at City Farms SLO, a nonprofit in San Luis Obispo that promotes sustainable agriculture and youth education. Prior to construction, the site experienced significant stormwater pooling and erosion in a central area of the farm, making daily operations and visitor access difficult during wet weather. The team excavated an 80-foot trench drain with appropriate slopes, installed a 15-foot corrugated HDPE culvert with proper bedding and backfill, built a seven-foot pedestrian bridge over the trench, and created a 17-foot gravel pathway connecting the bridge to an existing …

Residential Boundary Fence Installation In Oceano, Ca, Ulysses Beas

Construction Management

This Senior Project focuses on the planning and execution of a residential boundary wooden fence for an elderly homeowner located in Oceano, California, alongside a partial front yard renovation that was an appreciation gift from her grandson. Prior to construction, the front yard was divided by a small ornamental iron fence, which provided very little privacy. This fence installation was designed to improve privacy, security and overall safety while working alongside hired concrete laborers. Not only was the goal to improve safety but also the aesthetics of the home. This Project includes a project scope statement, site measurements, fence layout, …

The Impact Of Bilingual Superintendents On A Multilingual Job Site, Cesar Barajas

Construction Management

Language barriers are frequently encountered on construction job sites. Construction crews can often be limited in their proficiency when speaking English and in states like California, construction superintendents oversee a lot of Spanish-speaking crews. This study aims to identify if bilingual superintendents lead to better performing projects. Communication impacts major metrics of project performance including schedule, rework costs, safety performance, and coordination across trades. This qualitative study includes superintendents, project managers, and field crew semi structured interviews backed by survey answers. Interview participants discuss specific examples of how communication can affect jobsite performance both negatively and positively. Subjects are asked …

Post-Dobbs Realities: Ethical Imperatives For Data Transparency And Trust In Maternal Health Care, Faith E Fletcher, Sophie L Schott, Kelley Akhiemokhali, Kari White

Center for Medical Ethics and Health Policy Staff Publications

No abstract provided.

Defining The Society Of Pediatric Liver Transplantation (Split) Research Agenda: A Delphi Consensus Project, Sharad I Wadhwani, Pooja Reddy Spector, Amy G Feldman, Katryn N Furuya, Kayla Hartjes, Chaowapong Jarasvaraparn, Beau Kelly, Stacee M Lerret, Krupa Mysore, Arti Pawaria, Philip Rosenthal, Amy Shui, Voytek Slowik, Sarah Taylor, Jennifer Vittorio, Pamela L Valentino

Faculty, Staff and Students Publications

Background: Despite major advances in surgical and medical management, only one-third of pediatric liver transplant (LT) recipients remain morbidity-free at 10 years. The Society of Pediatric Liver Transplantation (SPLIT) published a research agenda over 10 years ago, and much progress has been made since then. An updated consensus-driven SPLIT research agenda could guide future research and funding priorities. We aimed to identify and prioritize key research needs across the continuum of pediatric LT care using a modified Delphi consensus approach.

Methods: We conducted a three-round modified Delphi process among SPLIT members. In round 1, participants submitted open-ended research priorities. In …

Rounding Styles On Inpatient Infectious Disease Consult Services: Impact On Education And Patient-Care Delivery, Melanie Kiener, Vanessa Ku, Prathit A Kulkarni

Faculty, Staff and Students Publications

Inpatient infectious disease (ID) consult services have recently been experiencing increased patient volumes due to a variety of factors, including higher patient complexity, increased patient turnover, growing rates of antimicrobial resistant infections, population aging, and ID outbreaks. As a result, increased time and resources have been required to continue to deliver high-quality medical care to patients. At academic teaching hospitals, providing patient care in the context of increased volumes must be balanced with the educational mission for trainees. Rounding is a central component of ID clinical work which brings together patient care and education. In this narrative review, we aim …

Distributed Battery-Free Bioelectronic Implants With Improved Network Power Transfer Efficiency Via Magnetoelectrics, Joshua E Woods, Fatima Alrashdan, Ellie C Chen, Wendy Tan, Mathews John, Lukas Jaworski, Drew Bernard, Allison Post, Angel Moctezuma-Ramirez, Abdelmotagaly Elgalad, Alexander G Steele, Sean M Barber, Philip J Horner, Amir H Faraji, Dimitry G Sayenko, Mehdi Razavi, Jacob T Robinson

Faculty, Staff and Students Publications

Networks of miniature implants could enable simultaneous sensing and stimulation at different locations in the body, such as the heart and central or peripheral nervous system. This capability would support precise disease tracking and treatment or enable prosthetic technologies with many degrees of freedom. However, wireless power and data transfer are often inefficient through biological tissues, particularly as the number of implanted devices increases. Here we show that magnetoelectric wireless data and power transfer supports a network of millimetre-sized bioelectronic implants in which system efficiency improves with additional devices. We demonstrate wireless, battery-free networks ranging from one to six implants, …

Statistical Methods In Aging Research: Improving Current Practices And Embracing Emerging Approaches, Deependra K Thapa, Erik S Parker, Mounika Kandukuri, Xi Rita Wang, Thirupathi R Mokalla, Olivia C Robertson, Wasiuddin Najam, Andrew E Teschendorff, Andrew W Brown, John R Speakman, Yisheng Peng, Bernard S Gorman, Heping Zhang, Luis-Enrique Becerra-Garcia, Colby J Vorland, David B Allison

Faculty, Staff and Students Publications

Aging research relies on varied statistical methods, and applying these methods appropriately is important for scientific rigor. However, proper use of these statistical techniques is a challenge. We discuss two categories of statistical methods in aging research: (a) emerging methods requiring further validation, including techniques to examine compression of morbidity, maximum lifespan, immortal time bias, molecular aging clocks, and treatment response heterogeneity, and (b) classic and existing methods needing reconsideration and improvement, such as stepwise regression, generalized linear models, methods for accounting for clustering and nesting effects, methods for testing for group differences, methods for mediation …

Pharmacodynamics, Efficacy, And Safety Of Intraputaminal Eladocagene Exuparvovec Administered To Pediatric Patients With Aromatic L-Amino Acid Decarboxylase Deficiency Using An Mr-Compatible Cannula: 48 Weeks Of Follow-Up, Daniel J Curry, Phillip L Pearl, Scellig S D Stone, Donald L Gilbert, Sudhakar Vadivelu, Bruria Ben-Zeev, Matthew Vestal, Muhammad Zafar, Chun-Hwei Tai, Sheng-Che Chou, Zion Zibly, Lior Ungar, Mered Parnes, Mariam Hull, Lisa Emrick, Christian Werner, Alexis Krolick, Vinay Penematsa, Antonia Wang, Rezwanur Rahman, Lee Golden, Yin-Hsiu Chien, Paul Wuh-Liang Hwu

Faculty, Staff and Students Publications

Aromatic ʟ‐amino acid decarboxylase (AADC) deficiency is a rare pediatric neurotransmitter disorder that typically necessitates lifelong care, and that carries a risk of childhood mortality. Eladocagene exuparvovec gene therapy is designed to restore AADC production. Study GT‐002 (NCT04903288) is a phase 2, multicenter, open‐label trial assessing the pharmacodynamics, safety, and efficacy of eladocagene exuparvovec administered to the putamen bilaterally in pediatric patients with AADC deficiency using a magnetic resonance (MR)‐compatible cannula. Patients received eladocagene exuparvovec at 1.8 × 1011 vector genomes via the SmartFlow MR‐compatible cannula in a single operative session. Endpoints include the change from baseline in …

Development Of Retrieval-Augmented Generation-Based Large Language Model For Drug-Induced Liver Injury Using Livertox Data, Ashwin Rao, George Cholankeril, Avegail Flores, Gagan Sood, Terrence E White, Fasiha Kanwal, Hashem B El-Serag

Faculty, Staff and Students Publications

Background: Idiosyncratic DILI is a complex clinical challenge requiring timely and accurate decision support. LiverTox, curated by the National Institute of Health (NIH), offers a comprehensive DILI evidence base, but its encyclopedia-like format hinders point-of-care use. Health care providers increasingly use general large language models (LLMs) for clinical care, raising safety concerns due to LLM hallucinations or misinformation. We hypothesize that retrieval-augmented generation (RAG) integration-grounding LLM responses in LiverTox content-would enable accurate DILI decision support.

Methods: We processed 1343 LiverTox drug monographs into 8759 indexed segments using BioBERT embeddings. We developed a RAG pipeline that employs drug-specific prioritization, section-aware weighting, …

Lonp1 Variants Are Associated With Clinically Diverse Phenotypes, Randee E Young, Lu Qiao, Rebecca Hernan, David A Sweetser, Jessica L Waxler, Daryl A Scott, Tiana M Scott, Seema R Lalani, Mahshid S Azamian, Jill A Rosenfeld, Bret Bostwick, Lindsay C Burrage, Lance H Rodan, Bianca E Russell, Marina Dutra-Clarke, Michael Kruer, Somayeh Bakhtiarim, Hossein Darvish, David J Amor, Shamima Rahman, Karen Stals, Lisa Bradley, Susan Byrne, Leandra K Tolusso, Beatrix Wong, Laura Benedict, Kimberly Wallis, Kestutis Micke, Cindy Colson, Thomas Smol, Sabrina V Southwick, Kristen A Miller, Michelle L Kush, Odelia Chorin, Annick Rothschild, Wei Wang, Yufeng Shen, Wendy K Chung

Faculty, Staff and Students Publications

LONP1 encodes a mitochondrial protease essential for protein quality control and metabolism. Variants in LONP1 are associated with a diverse and expanding spectrum of disorders, including Cerebral, Ocular, Dental, Auricular, and Skeletal anomalies syndrome (CODAS), congenital diaphragmatic hernia (CDH), and neurodevelopmental disorders (NDD), with some individuals exhibiting features of mitochondrial encephalopathy. We report 16 novel LONP1 variants identified in 16 individuals (11 with NDD, 5 with CDH), further expanding the clinical spectrum. Structural mapping of disease-associated missense variants revealed phenotype-specific clustering, with CODAS variants enriched in the proteolytic chamber and NDD variants more broadly distributed. CODAS is caused by biallelic …

Government Religious Speech And The Establishment Clause, Mark Storslee Associate Professor, Michael Helfand

Vanderbilt Law Review

The government says religious things. From monuments and holiday displays to legislative prayers, religion saturates the government's public voice. But how can that be permissible when the Establishment Clause, at least in theory, indicates the government should be religiously neutral?
So far, the Supreme Court's attempts to address the puzzle have come up short. Early on, the Court suggested that seemingly all government speech must be secular, or that it refrain from "endorsing" religion. But the Court never consistently enforced those limits, struggling to reconcile them with America's historical experience. And in recent years, the Court has rejected those approaches …

Active Bone Marrow Dose Reconstruction In A Large-Scale Cohort Study Of Cancer Patients Treated With Photon Radiotherapy, Keith T Griffin, Kishan J Pithadia, Yeon Soo Yeom, Lior Braunstein, Kelly L Bolton, Lindsay M Morton, Choonsik Lee

2020-Current year OA Pubs

BACKGROUND: Previous studies have investigated the dose-response relationship between external beam radiotherapy (EBRT) and leukemia by reconstructing the mean active bone marrow (ABM) dose as part of the exposure assessment. However, no prior study has leveraged electronic medical records (EMR) to reconstruct ABM dose and dose-volume in an EBRT patient population.

PURPOSE: To support future studies on the relationship between radiation exposure and adverse health effects among EBRT patients, we demonstrate methods to retrospectively calculate ABM dose and dose-volume metrics in a large patient cohort using EMR.

METHODS: We retrieved complete EMR for 639 individuals (five pediatric and 634 adult) …

Linkage Disequilibrium Score Regression Identifies Genetic Correlations Between Hepatocellular Carcinoma And Clinically Relevant Traits, Younghun Han, Vikram R Shaw, Jinyoung Byun, Aaron P Thrift, Catherine Zhu, Donghui Li, Rikita I Hatia, Robin Kate Kelley, Sean P Cleary, Anna S Lok, Paige M Bracci, Jennifer B Permuth, Roxana Bucur, Jennifer Knox, Jian-Min Yuan, Amit G Singal, Prasun K Jalal, R Mark Ghobrial, Yuko Kono, Dimpy P Shah, Mindie H Nguyen, Neehar D Parikh, Richard Kim, Hui-Chen Wu, Hashem El-Serag, Ping Chang, Yun Shin Chun, Jian Gu, Chad Huff, Asif Rashid, Lu-Yu Hwang, Alison P Klein, Saira A Khaderi, Ahmed O Kaseb, Kathrine A Mcglynn, Lewis R Roberts, Manal M Hassan, Christopher I Amos

Faculty, Staff and Students Publications

Hepatocellular carcinoma (HCC) mortality is increasing globally, partly due to the growing prevalence of nonviral liver diseases. Genome-wide association studies (GWAS) have identified genetic variants associated with HCC development. Leveraging GWAS summary statistics and linkage disequilibrium score regression (LDSR), we investigated disease co-development with hepatitis C virus-negative (HCV-negative) HCC to provide unique insights into HCC etiology and prioritize relationships for further causal inquiry. We utilized the LDSR statistical framework to estimate the genetic correlation and heritability between HCV-negative HCC with 901 epidemiologic, behavioral, and clinical traits from the United Kingdom Biobank (UKBB). First, we set the threshold for observed scale …

Communicating Across Languages: Experiences Of Spanish-Speaking People With Dementia And Care Partners In The Emergency Department, Anita N Chary, Victor Lara, Sumin Yoon, Annika R Bhananker, Edgar Ordoñez, Michelle I Suh, Manish N Shah

Faculty, Staff and Students Publications

No abstract provided.