Digital Commons Network^™

Book Review: Smokescreen: Debunking Wildfire Myths To Save Our Forests And Climate, Brenda Macías López

Natural Resources Journal

No abstract provided.

Protocol For The Phase 2 Edelife Trial Investigating The Efficacy And Safety Of Intra-Amniotic Er004 Administration To Male Subjects With X-Linked Hypohidrotic Ectodermal Dysplasia, Holm Schneider, Smail Hadj-Rabia, Florian Faschingbauer, Christine Bodemer, Dorothy K Grange, Mary E Norton, Riccardo Cavalli, Gianluca Tadini, Holger Stepan, Angus Clarke, Encarna Guillén-Navarro, Sigrun Maier-Wohlfart, Athmane Bouroubi, Florence Porte

2020-Current year OA Pubs

X-linked hypohidrotic ectodermal dysplasia (XLHED) is a rare genetic disorder characte-rised by abnormal development of the skin and its appendages, such as hair and sweat glands, the teeth, and mucous glands of the airways, resulting in serious, sometimes life-threatening complications like hyperthermia or recurrent respiratory infections. It is caused by pathogenic variants of the ectodysplasin A gene (

Excretory/Secretory Proteome Of Females And Males Of The Hookworm Ancylostoma Ceylanicum, Samuel C Uzoechi, Bruce A Rosa, Kumar Sachin Singh, Young-Jun Choi, Bethany K Bracken, Paul J Brindley, R Reid Townsend, Robert Sprung, Bin Zhan, Maria-Elena Bottazzi, John M Hawdon, Yide Wong, Alex Loukas, Sergej Djuranovic, Makedonka Mitreva

Faculty, Staff and Students Publications

The dynamic host-parasite mechanisms underlying hookworm infection establishment and maintenance in mammalian hosts remain poorly understood but are primarily mediated by hookworm’s excretory/secretory products (ESPs), which have a wide spectrum of biological functions. We used ultra-high performance mass spectrometry to comprehensively profile and compare female and male ESPs from the zoonotic human hookworm Ancylostoma ceylanicum, which is a natural parasite of dogs, cats, and humans. We improved the genome annotation, decreasing the number of protein-coding genes by 49% while improving completeness from 92 to 96%. Compared to the previous genome annotation, we detected 11% and 10% more spectra in …

What Are You Looking At? Emerging Privacy Concerns With Eye Tracking In Virtual Reality, Richard Koch

Colorado Technology Law Journal

No abstract provided.

Full Issue: Summer 2016

DePaul Magazine

This issue of DePaul Magazine recounts the story of alumni Olympian Mabel “Dolly” Staton (EDU ’55) who competed at the 1952 Olympics in Helsinki. Also, learn how DePaul’s Institute for Housing Studies and others examine gentrification in Chicago, find out about DePaul students participating in The Cities Project to help children with the stress of living in urban poverty, and meet alumni who curate exhibitions at museums and galleries.

Full Issue: Summer 2018

DePaul Magazine

The latest issue of DePaul Magazine is now available. In the cover story, see how weathercaster Paul Konrad (THE '87) combines his theatre background and meteorology training as he entertains and informs viewers on WGN-TV Chicago. Get an inside look at his career in "Sunshine State of Mind."

Full Issue: Summer 2020

DePaul Magazine

Concerns about our health have taken center stage in countries around the world. Even before the novel coronavirus emerged, DePaul University was focusing on the need for research and education centered on the health sciences. This issue of DePaul Magazine looks at such timely and urgent topics as traumatic brain injury, nursing, speech language pathology, occupational health and heart disease. It also provides an update on DePaul's response to COVID-19 and the opening of a completely renovated space for opera performance. Please enjoy the summer 2020 issue of DePaul Magazine.

Antagonistic Effect Of Cyclin-Dependent Kinases And A Calcium-Dependent Phosphatase On Polyglutamine-Expanded Androgen Receptor Toxic Gain Of Function, Diana Piol, Laura Tosatto, Emanuela Zuccaro, Eric N Anderson, Antonella Falconieri, Maria J Polanco, Caterina Marchioretti, Federica Lia, Joseph White, Elisa Bregolin, Giovanni Minervini, Sara Parodi, Xavier Salvatella, Giorgio Arrigoni, Andrea Ballabio, Albert R La Spada, Silvio C E Tosatto, Fabio Sambataro, Diego L Medina, Udai B Pandey, Manuela Basso, Maria Pennuto

Duncan NRI Faculty and Staff Publications

Spinal and bulbar muscular atrophy is caused by polyglutamine (polyQ) expansions in androgen receptor (AR), generating gain-of-function toxicity that may involve phosphorylation. Using cellular and animal models, we investigated what kinases and phosphatases target polyQ-expanded AR, whether polyQ expansions modify AR phosphorylation, and how this contributes to neurodegeneration. Mass spectrometry showed that polyQ expansions preserve native phosphorylation and increase phosphorylation at conserved sites controlling AR stability and transactivation. In small-molecule screening, we identified that CDC25/CDK2 signaling could enhance AR phosphorylation, and the calcium-sensitive phosphatase calcineurin had opposite effects. Pharmacologic and genetic manipulation of these kinases and phosphatases modified polyQ-expanded AR …

Multimodal Brain Age Estimates Relate To Alzheimer Disease Biomarkers And Cognition In Early Stages: A Cross-Sectional Observational Study, Peter R Millar, Brian A Gordon, Patrick H Luckett, Tammie L S Benzinger, Carlos Cruchaga, Anne M Fagan, Jason J Hassenstab, Richard J Perrin, Suzanne E Schindler, Randall J Bateman, John C Morris, Beau M Ances, Et Al.

2020-Current year OA Pubs

BACKGROUND: Estimates of 'brain-predicted age' quantify apparent brain age compared to normative trajectories of neuroimaging features. The brain age gap (BAG) between predicted and chronological age is elevated in symptomatic Alzheimer disease (AD) but has not been well explored in presymptomatic AD. Prior studies have typically modeled BAG with structural MRI, but more recently other modalities, including functional connectivity (FC) and multimodal MRI, have been explored.

METHODS: We trained three models to predict age from FC, structural (S), or multimodal MRI (S+FC) in 390 amyloid-negative cognitively normal (CN/A-) participants (18-89 years old). In independent samples of 144 CN/A-, 154 CN/A+, …

Excretory/Secretory Proteome Of Females And Males Of The Hookworm Ancylostoma Ceylanicum, Samuel C Uzoechi, Bruce A Rosa, Kumar Sachin Singh, Young-Jun Choi, Bethany K Bracken, Paul J Brindley, R Reid Townsend, Robert Sprung, Bin Zhan, Maria-Elena Bottazzi, John M Hawdon, Yide Wong, Alex Loukas, Sergej Djuranovic, Makedonka Mitreva

2020-Current year OA Pubs

The dynamic host-parasite mechanisms underlying hookworm infection establishment and maintenance in mammalian hosts remain poorly understood but are primarily mediated by hookworm's excretory/secretory products (ESPs), which have a wide spectrum of biological functions. We used ultra-high performance mass spectrometry to comprehensively profile and compare female and male ESPs from the zoonotic human hookworm

Establishing 3d Endometrial Organoids From The Mouse Uterus, Suni Tang, Sydney E Parks, Zian Liao, Dominique I Cope, Sarah E Blutt, Diana Monsivais

Faculty, Staff and Students Publications

Endometrial tissue lines the inner cavity of the uterus and is under the cyclical control of estrogen and progesterone. It is a tissue that is composed of luminal and glandular epithelium, a stromal compartment, a vascular network, and a complex immune cell population. Mouse models have been a powerful tool to study the endometrium, revealing critical mechanisms that control implantation, placentation, and cancer. The recent development of 3D endometrial organoid cultures presents a state-of-the-art model to dissect the signaling pathways that underlie endometrial biology. Establishing endometrial organoids from genetically engineered mouse models, analyzing their transcriptomes, and visualizing their morphology at …

Seroprevalence And Titer Concentration Testing For Leptospirosis In Equine, Ashley Himmelsbaugh

Posters-at-the-Capitol

The most common best management practice used to combat diseases in horses is vaccination, which can decrease the incidence or severity of illness. However, the duration of immunity will vary for each vaccination and must be considered for revaccination purposes. Titer concentration, which evaluates antibodies in the blood, may be a helpful way of determining how long an animal has immunity to a disease. Leptospirosis, a zoonotic, bacterial disease, can result in uveitis, potentially leading to blindness, and abortion in mares. One serovar, Leptospirosis pomona (L. pomona), is associated with most cases of clinical disease in horses in North America. …

Pharmacokinetics Of Cbd Supplementation In Horses: Single Dose Vs. Long-Term Feeding, Madilyn Adamchik

Posters-at-the-Capitol

Research about supplemental feeding of cannabidiol (CBD) to horses is still in its early stages, but owners are feeding CBD to relieve pain and calm behavioral issues. Cannabinoids work through the endocannabinoid system to modulate nervous and hormonal actions in the body. The objectives of this study were to evaluate the pharmacokinetics of single dose versus long-term feeding of a pelleted CBD supplement. In Project 1, eighteen Quarter Horse geldings were given a single dose of 50 mg (n=6), 100 mg (n=6), or 250 mg (n=6) of pelleted CBD. Blood samples were collected before treatment (0 hrs), and at 0.5, …

Full Issue: Spring 2022

DePaul Magazine

In this issue of DePaul Magazine we celebrate the legacy and contributions of A. Gabriel Esteban, PhD, 12th president of DePaul University, as he steps down from his position at the end of the academic year. Also: Casting director and alumna Brittani Ward brings her Hollywood career home to Chicago, two faculty members mine pop culture to discover keys to our changing social landscape, and an alumna and her family think big picture with a gift supporting the community-engagement efforts of DePaul's Visual Art Education program.

Subject Index, Colorado General Assembly

Colorado House and Senate Journals

No abstract provided.

Sheep Grazing Trigonella Balansae Had Productivity, Health And Meat Quality Similar To Sheep Grazing Subterranean Clover Or French Serradella, M. G. Wilmot, Hayley C. Norman, Joshua Hendry, Paul Young, Elizabeth Hulm, Andrew Toovey, Jane Speijers, Robert J. Harrison

Animal production and livestock research articles

Context: An accession of the annual legume Trigonella balansae Boiss. & Reuter. has been selected for commercial release in Australia.

Aims: As part of a duty-of-care assessment, we tested the hypothesis that sheep grazing the trigonella accession will have liveweight, condition scores and wool production similar to those of sheep grazing two widely adopted annual legumes, subterranean clover (subclover, Trifolium subterraneum L. cv. Dalkeith) and French serradella (Ornithopus sativus Brot. cv. Erica). We also hypothesised that sheep grazing the three legumes will have similar meat quality and health, as indicated by blood plasma panel analysis.

Methods: Wethers (n …

Full Issue: Summer 2022

DePaul Magazine

In the latest issue of DePaul Magazine, we look at how Eugene P. Jarvis, a trailblazer in the video game industry, and his wife, DePaul Trustee Sasha L. Gerritson (MUS '99), are taking DePaul's College of Computing and Digital Media to the next level with a landmark gift to spur innovation. Also: Robert L. Manuel becomes DePaul's 13th president, DePaul alumnus Jon Irabagon (MUS '00) charts his own course in the jazz world as a performer, composer and producer, initiatives across campus amplify DePaul's commitment to diversity, equity and inclusion (DEI), and DePaul Originals Game Studio Creative Director Allen Turner …

Evidence Of Mirror Self-Recognition In Beluga Whales, Alexander Mildener

Theses and Dissertations

Four beluga whales (Delphinapterus leucas) were tested for mirror self-recognition at the New York Aquarium. The whales were exposed to a mirror and a non-reflective plexiglass control. Two whales, Natasha and Maris, demonstrated self-directed behavior and Natasha passed one mark-test. Two whales demonstrated compelling evidence for MSR.

Bloody Show, Leonie Weber

Theses and Dissertations

Leonie Weber reflects on how reproductive, domestic, and emotional labor is addressed in her artwork, and her experience as an artist-parent in the art world. Moreover, she specifically discusses mothers who are navigating their own artistic paths. Her practice encompasses sculpture, printmaking, performance, and installation.

Establishing An In Vitro Model To Study Avian Carotenoid Ketolation, Chidimma Okegbe

Electronic Theses and Dissertations Archive

Carotenoid coloration is among the most widely recognized condition-dependent signal of quality in animals. This project first explored the possibility of establishing an in-vitro model to study carotenoid ketolation in two avian species, where both species use red keto-carotenoids for plumage pigmentation. Secondly, this project tested whether the carotenoid ketolation pathway would be affected by antioxidant and mitochondrial uncoupler treatments. We observed that most carotenoid ketolation could happen in in-vitro settings using primary hepatocytes for both House Finch and Domestic Canary. However, interestingly, the in-vitro system using House Finch hepatocytes failed to convert β-cryptoxanthin to 3-HE. Then, we tested the …

Full Issue: Fall 2021

DePaul Magazine

Disruption has taken on positive connotations when it comes to innovating everything from communication technology to business structures. COVID-19, however, forced disruptions across all aspects of life as we knew it. This issue of DePaul Magazine features a special report on how four sectors—transportation, hospitality, entertainment and education—have reacted to the challenges wrought by the pandemic. We also take a look at a documentary produced by an alumna to showcase the charitable work of a Honduran nun. Finally, we update two programs previously covered in DePaul Magazine to see what progress they have made since they were first launched.

The Weekly Challenger, January 5, 2023, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The January 5, 2023, issue of The Weekly Challenger.

Targeting Brd4 And Pi3k Signaling Pathways For The Treatment Of Medulloblastoma, Bharti Sethi, Virender Kumar, Thilina D. Jayasinghe, Yuxiang Dong, Donald R. Ronning, Haizhen Zhong, Donald W. Coulter, Ram I. Mahato

Chemistry Faculty Publications

Medulloblastoma (MB) is a malignant pediatric brain tumor which shows upregulation of MYC and sonic hedgehog (SHH) signaling. SHH inhibitors face acquired resistance, which is a major cause of relapse. Further, direct MYC oncogene inhibition is challenging, inhibition of MYC upstream insulin-like growth factor/ phosphatidylinositol-4,5-bisphosphate 3-kinase (IGF/PI3K) is a promising alternative. While PI3K inhibition activates resistance mechanisms, simultaneous inhibition of bromodomain-containing protein 4 (BRD4) and PI3K can overcome resistance. We synthesized a new molecule 8-(2,3-dihydrobenzo[b] [1, 4] dioxin-6-yl)-2-morpholino-4H-chromen-4-one (MDP5) that targets both BRD4 and PI3K pathways. We used X-ray crystal structures and a molecular modeling approach to confirm the interactions …

Characterization, Antibacterial, Antioxidant, Antidiabetic, And Anti-Inflammatory Activities Of Green Synthesized Silver Nanoparticles Using Phragmanthera Austroarabica A. G. Mill And J. A. Nyberg Extract, Shady Swidan, Dina Khodeer, Sarah Shabayek, Ali Nasr, Roaa Khinkar, Mohammed Aldurdunji, Maryam Ramadan, Jihan Badr

Pharmacy

Introduction: Diabetes mellitus is a chronic metabolic disorder that exhibited great expansion all over the world. It is becoming an epidemic disease adding a major burden to the health care system, particularly in developing countries.

Methods: The plant under investigation in the current study Phragmanthera austroarabica A. G. Mill and J. A. Nyberg is traditionally used in Saudi Arabia for the treatment of diabetes mellitus. The methanolic extract (200 mg/kg) of the plant and pure gallic acid (40 mg/kg), a major metabolite of the plant, as well as their silver nanoparticle formulae (AgNPs) were evaluated for their antidiabetic activity.

Results …

Sickle Red Blood Cell-Derived Extracellular Vesicles Activate Endothelial Cells And Enhance Sickle Red Cell Adhesion Mediated By Von Willebrand Factor, Ran An, Yuncheng Man, Kevin Cheng, Tianyi Zhang, Fang Wang, Erdem Kucukal, William J. Wulftange, Utku Goreke, Allison Bode, Lalitha V. Nayak, Jane A. Little, Umut A. Gurkan

Faculty Scholarship

Endothelial activation and sickle red blood cell (RBC) adhesion are central to the pathogenesis of sickle cell disease (SCD). Quantitatively, RBC-derived extracellular vesicles (REVs) are more abundant from SS RBCs compared with healthy RBCs (AA RBCs). Sickle RBC-derived REVs (SS REVs) are known to promote endothelial cell (EC) activation through cell signalling and transcriptional regulation at longer terms. However, the SS REV-mediated short-term non-transcriptional response of EC is unclear. Here, we examined the impact of SS REVs on acute microvascular EC activation and RBC adhesion at 2 h. Compared with AA REVs, SS REVs promoted human pulmonary microvascular ECs (HPMEC) …

An Entosis-Like Process Induces Mitotic Disruption In Pals1 Microcephaly Pathogenesis, Noelle A Sterling, Jun Young Park, Raehee Park, Seo-Hee Cho, Seonhee Kim

Center for Translational Medicine Faculty Papers

Entosis is cell cannibalism utilized by tumor cells to engulf live neighboring cells for pro- or anti-tumorigenic purposes. It is unknown whether this extraordinary cellular event can be pathogenic in other diseases such as microcephaly, a condition characterized by a smaller than normal brain at birth. We find that mice mutant for the human microcephaly-causing gene Pals1, which exhibit diminished cortices due to massive cell death, also exhibit nuclei enveloped by plasma membranes inside of dividing cells. These cell-in-cell (CIC) structures represent a dynamic process accompanied by lengthened mitosis and cytokinesis abnormalities. As shown in tumor cells, ROCK inhibition completely …

Regrowing The Heart, One Tree At A Time, Jeffrey D Steimle, James F Martin

Faculty, Staff and Students Publications

While many animals can completely repair injured tissues, the mammalian heart possesses limited regenerative capabilities. Yan and Cigliola et al. show that AAV-mediated, zebrafish-derived tissue regeneration enhancer elements (TREEs) can direct pro-regenerative gene expression in injured cardiac tissue of mice and pigs that turn off following repair.

Fire Impacts And Dynamics Of Seasonally Dry Tropical Forest Of East Java, Indonesia, Sutomo, Eddie J. B. Van Etten

Research outputs 2022 to 2026

Background: Seasonally dry tropical forests (SDTFs) are globally important ecosystems which receive less research attention compared to tropical rainforests but are equally under serious threat. The objectives of this paper are to characterize the vegetation structure, diversity and composition of SDTF of Baluran National Park, East Java, Indonesia, and to assess the impact of burning this SDTF and its post-fire recovery. Methods: In the field, we measured floristic composition and dominance at sites with different fire histories in both SDTF and adjacent savannas of Baluran. Remote sensing image analysis was also employed using the MODIS burn area product and various …

Cellular Zinc Deficiency Impairs Heme Biosynthesis In Developing Erythroid Progenitors, Juyoung Kim, Jaekwon Lee, Moon-Suhn Ryu

Department of Biochemistry: Faculty Publications

Anemia is the most prevalent nutrition-related disorder worldwide. Zinc is an essential trace element for various biological processes in the body, and zinc deficiency has been associated with anemia in humans. However, the molecular mechanisms by which zinc availability alters red blood cell development remain uncertain. The present study identifies the essentiality of zinc during erythroid development, particularly for normal heme biosynthesis. G1E-ER4 mouse cells were used as an in vitro model of terminal erythroid differentiation, which featured elevated cellular zinc content by development. Restriction of zinc import compromised the rate of heme and -globin production and, thus, the hemoglobinization …

Scavenger Receptor B1 Facilitates The Endocytosis Of Escherichia Coli Via Tlr4 Signaling In Mammary Gland Infection, Qamar Taban, Syed Mudasir Ahmad, Peerzada Tajamul Mumtaz, Basharat Bhat, Ehtishamul Haq, Suhail Magray, Sahar Saleem, Nadeem Shabir, Amatul Muhee, Zahid Amin Kashoo, Mahrukh Hameed Zargar6, Abrar A. Malik, Nazir A. Ganai, Riaz A. Shah

Department of Nutrition and Health Sciences: Faculty Publications

SCARB1 belongs to class B of Scavenger receptors (SRs) that are known to be involved in binding and endocytosis of various pathogens. SRs have emerging role in regulating innate immunity and host–pathogen interactions by acting in co-ordination with Toll-like receptors.Query Little is known about the function of SCARB1 in milk-derived mammary epithelial cells (MECs). This study reports the role of SCARB1 in infection and its potential association in TLR4 signaling on bacterial challenge in Goat mammary epithelial cells (GMECs). The novelty in the establishment of MEC culture lies in the method that aims to enhance the viability of the cells …