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Articles 86071 - 86100 of 733206

Full-Text Articles in Entire DC Network

Mouse Phenome Database: Towards A More Fair-Compliant And Trust-Worthy Data Repository And Tool Suite For Phenotypes And Genotypes., Molly A. Bogue, Robyn L Ball, Vivek M. Philip, David O Walton, Matthew H Dunn, Georgi Kolishovski, Anna Lamoureux, Matthew Gerring, Hongping Liang, Jake Emerson, Timothy M Stearns, Hao He, Gaurab Mukherjee, John Bluis, Sejal Desai, Beth A. Sundberg, Beena Kadakkuzha, Govindarajan Kunde-Ramamoorthy, Elissa J Chesler Jan 2023

Mouse Phenome Database: Towards A More Fair-Compliant And Trust-Worthy Data Repository And Tool Suite For Phenotypes And Genotypes., Molly A. Bogue, Robyn L Ball, Vivek M. Philip, David O Walton, Matthew H Dunn, Georgi Kolishovski, Anna Lamoureux, Matthew Gerring, Hongping Liang, Jake Emerson, Timothy M Stearns, Hao He, Gaurab Mukherjee, John Bluis, Sejal Desai, Beth A. Sundberg, Beena Kadakkuzha, Govindarajan Kunde-Ramamoorthy, Elissa J Chesler

Faculty Research 2023

The Mouse Phenome Database (MPD; https://phenome.jax.org; RRID:SCR_003212), supported by the US National Institutes of Health, is a Biomedical Data Repository listed in the Trans-NIH Biomedical Informatics Coordinating Committee registry. As an increasingly FAIR-compliant and TRUST-worthy data repository, MPD accepts phenotype and genotype data from mouse experiments and curates, organizes, integrates, archives, and distributes those data using community standards. Data are accompanied by rich metadata, including widely used ontologies and detailed protocols. Data are from all over the world and represent genetic, behavioral, morphological, and physiological disease-related characteristics in mice at baseline or those exposed to drugs or other treatments. MPD …

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Full Issue: Fall 2019 Jan 2023

Full Issue: Fall 2019

DePaul Magazine

This issue of DePaul Magazine announces the establishment of The Grace School of Applied Diplomacy in the College of Liberal Arts and Social Sciences. Learn more about transprofessional diplomacy and this exciting new endeavor in the cover story "Expanding the Borders of Diplomacy."

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Hemispheric Reconstructions: Post-Emancipation Social Movements And Capitalist Reaction In Colombia And The United States, James E. Sanders Jan 2023

Hemispheric Reconstructions: Post-Emancipation Social Movements And Capitalist Reaction In Colombia And The United States, James E. Sanders

History Faculty Publications

As historians have begun to conceptualize the U.S. Civil War as a global event, so too must they consider Reconstruction as a political process that transcended national boundaries. The United States and Colombia both abolished slavery during civil wars; ex-slaves in both societies struggled for full citizenship and landholding, partially succeeding for a time; in both societies, a harsh reaction ripped full citizenship from the freedpeople and denied their claims to the land. These events, usually studied only as part of a national story in either the United States or Colombia, can also be understood, and perhaps be better understood, …

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Thirteen New Species Of Butterflies (Lepidoptera: Hesperiidae) From Texas, Jing Zhang, Qian Cong, Nick V. Grishin Jan 2023

Thirteen New Species Of Butterflies (Lepidoptera: Hesperiidae) From Texas, Jing Zhang, Qian Cong, Nick V. Grishin

Insecta Mundi

Analyses of whole genomic shotgun datasets, COI barcodes, morphology, and historical literature suggest that the following 13 butterfly species from the family Hesperiidae (Lepidoptera: Papilionoidea) in Texas, USA are distinct from their closest named relatives and therefore are described as new (type localities are given in parenthesis): Spicauda atelis Grishin, new species (Hidalgo Co., Mission), Urbanus (Urbanus) rickardi Grishin, new species (Hidalgo Co., nr. Madero), Urbanus (Urbanus) oplerorum Grishin, new spe­cies (Hidalgo Co., Mission/Madero), Telegonus tsongae Grishin, new species (Starr Co., Roma), Autochton caballo Grishin, new species (Hidalgo Co., 6 mi W of Hidalgo), Epargyreus fractigutta …

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Desire In The Iliad: The Force That Moves The Epic And Its Audience, Rachel H. Lesser Jan 2023

Desire In The Iliad: The Force That Moves The Epic And Its Audience, Rachel H. Lesser

Gettysburg College Faculty Books

This book is the first study to examine desire in the Iliad in a comprehensive way and to explain its relationship to the epic’s narrative structure and audience reception. It offers a new reading of the poem that shows how the characters’ desires, especially those of the mortal hero Achilleus and the divine king Zeus, motivate plot and keep the audience engaged with the epic until and even beyond its end. The author argues that the characters’ desires are primarily organized in narrative triangles that feature two parties in conflict over a third. A variety of desires animate these triangles, …

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Temperature Fluctuation Alters Optimal Predator Community Composition For Anticipated Biological Control, Amanda N. Laubmeier, Nusrat Tabassum, Brigitte Tenhumberg Jan 2023

Temperature Fluctuation Alters Optimal Predator Community Composition For Anticipated Biological Control, Amanda N. Laubmeier, Nusrat Tabassum, Brigitte Tenhumberg

School of Biological Sciences: Faculty Publications

Alongside pesticides and specialist predators, natural communities of generalist beetle and spider predators play an important role in suppressing agricultural pests. However, the predation pressure of natural communities can be unpredictable. Overall predation pressure is influenced by a dense network of potential intraguild interactions, which are further shaped by species traits and environmental factors. Understanding how these different influences combine to impact pest control is especially important in the context of changing global temperatures. Recent empirical studies have demonstrated that the foraging behavior of arthropod predators is influenced by an interaction between temperature and predator body size. To explore the …

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Full Issue: Fall 2018 Jan 2023

Full Issue: Fall 2018

DePaul Magazine

DePaul's new president, A. Gabriel Esteban, PhD, and his wife, Jo, talk about their lives and their first year at DePaul in this issue of DePaul Magazine. Discover their favorite places in Chicago in "The Road to DePaul."

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Mouse Pancreatic Peptide Hormones Probed At The Sub-Single-Islet Level: The Effects Of Acute Corticosterone Treatment, Aleksandra Antevska, Connor C. Long, Samuel D. Dupuy, J. Jason Collier, Michael D. Karlstad, Thanh D. Do Jan 2023

Mouse Pancreatic Peptide Hormones Probed At The Sub-Single-Islet Level: The Effects Of Acute Corticosterone Treatment, Aleksandra Antevska, Connor C. Long, Samuel D. Dupuy, J. Jason Collier, Michael D. Karlstad, Thanh D. Do

Division of Basic Science Faculty Publications

We combine liquid chromatography coupled with ion mobility spectrometry-mass spectrometry to elucidate how short exposure to corticosterone (Cort) alters the output of mouse pancreatic islet hormones. The workflow enables the robust separation of mouse insulin 1 (Ins1) and insulin 2 (Ins2) and the detection of major islet hormones in a homogenate equivalent to 100-150 islet cells. We show that Ins2 has a unique structure and is degraded much faster than Ins1. Further investigation indicates that Ins2 may populate both T and R states, whereas Ins1 may not. The assemblies of Ins1’s B-chain also introduce more structural heterogeneity than Ins2. Collectively, …

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The Evolution Of Life History Traits And Their Thermal Plasticity In Daphnia, Larry L. Bowman Jr., David M. Post Jan 2023

The Evolution Of Life History Traits And Their Thermal Plasticity In Daphnia, Larry L. Bowman Jr., David M. Post

ETSU Faculty Works

Few studies have explored the relative strength of ecogeographic versus lineage-specific effects on a global scale, particularly for poikilotherms, those organisms whose internal temperature varies with their environment. Here, we compile a global dataset of life history traits in Daphnia, at the species-and population-level, and use those data to parse the relative influences of lineage-specific effects and climate. We also compare the thermal response (plasticity) of life history traits and their dependence on climate, temperature, precipitation, and latitude. We found that the mode of evolution for life history traits varies but that the thermal response of life history traits most …

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Design And Synthesis Of Substituted N,3,3-Triphenylpropanamide And 1-Benzhydryl-N-Phenylazetidine-3-Carboxamide Analogs And Their Biological Evaluation, Michael Dorogan Jan 2023

Design And Synthesis Of Substituted N,3,3-Triphenylpropanamide And 1-Benzhydryl-N-Phenylazetidine-3-Carboxamide Analogs And Their Biological Evaluation, Michael Dorogan

Theses and Dissertations

As D1R agonism has significant implications in the treatment of cognitive deficits, we sought to develop novel D1R PAMs, through the derigidification of BMS D1R PAM hit compound. While we were able to synthesize derigidified analogs of the BMS hit compound, derigidification did not produce active D1R ligands.

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Children And The Cold War: Race & Hypocrisy Amid Fear Of Nuclear War, Richard D. Mctaggart Jr. Jan 2023

Children And The Cold War: Race & Hypocrisy Amid Fear Of Nuclear War, Richard D. Mctaggart Jr.

Theses and Dissertations

During the Cold War, American propaganda centered the wellbeing of the child in its messaging warning of atomic attack at the hands of the Soviet Union. However, despite American claims that all children were valued by the United States, this was proven untrue by its unequal treatment of Black children.

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Paper, Clay, And Thread: Tools Of Decolonization In The Work Of Guadalupe Maravilla, Juan Javier Salazar, And Julieth Morales, Alexandra J. Goldman Jan 2023

Paper, Clay, And Thread: Tools Of Decolonization In The Work Of Guadalupe Maravilla, Juan Javier Salazar, And Julieth Morales, Alexandra J. Goldman

Theses and Dissertations

This thesis contains case studies on artwork by Guadalupe Maravilla, Juan Javier Salazar, and Julieth Morales. Each chapter focuses on one important medium in ancient American indigenous art - cartography, ceramics, and textiles – as explored in-depth by a contemporary artist from a region in which the medium has significant roots.

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“This Little Patch Of Earth Is Inexhaustible”: Ernst Ludwig Kirchner And The Outdoors Movements, Erica Evans Jan 2023

“This Little Patch Of Earth Is Inexhaustible”: Ernst Ludwig Kirchner And The Outdoors Movements, Erica Evans

Theses and Dissertations

This thesis focuses on the influence of reform movements and hiking and mountaineering organizations on the life and work of Ernst Ludwig Kirchner. I explore how principles of these outdoors movements, including a healthy mind/body connection and rustic lifestyle, inform Kirchner’s works created while living in Davos, Switzerland.

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Artist-Scholar: Tradition And Modernity In The Work Of Tseng Yuho, Jennie Tang Jan 2023

Artist-Scholar: Tradition And Modernity In The Work Of Tseng Yuho, Jennie Tang

Theses and Dissertations

Chinese American artist-scholar Tseng-Yuho (1925-2017) developed an original, modern style called dsui hua based on her extensive knowledge of traditional Chinese ink art and scroll mounting techniques, Chinese and Western art history, and experiences living in or travelling to mainland China, Taiwan, Hong Kong, Paris, Hawai‘i, and New York.

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“W”: Women In Afropop Entertainment At The Intersection Of Race, Gender, Sexuality, And Culture, Coreen Robledo Jan 2023

“W”: Women In Afropop Entertainment At The Intersection Of Race, Gender, Sexuality, And Culture, Coreen Robledo

Theses and Dissertations

Performing artist uses a personal and historical viewpoint as a catalyst to discuss some women's challenges in the Afropop and African entertainment by offering social, patriarchal, cultural, and sexual contexts that the writer argues construct the images, reputations, decision-making, and circumstances of Brown and Black women in the entertainment industry.

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New Music For A New World: Robert Ashley’S Television Operas, Nicole Kaack Jan 2023

New Music For A New World: Robert Ashley’S Television Operas, Nicole Kaack

Theses and Dissertations

Robert Ashley defined the majority of his works as “television operas”—spoken narrative music for television broadcast. Analyzing Ashley’s works through their cross-disciplinarity, this thesis addresses the development of Ashley’s chosen medium; assesses his use of visual, linguistic, and musical structures; and interprets their basis in American cultural identity.

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Cashing Out (Documentary), Girard Tecson Jan 2023

Cashing Out (Documentary), Girard Tecson

Theses and Dissertations

My 30-minute documentary film, Cashing Out, explores my journey into the world of sneaker culture and the major impact it made in my life.

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Revolutionary Women, Fredgy Noël Jan 2023

Revolutionary Women, Fredgy Noël

Theses and Dissertations

Revolutionary Women is a five screen video installation that honors five women leaders of the Haitian Revolution that lasted from August 22, 1791- January 1, 1804. Women revolutionaries are almost non-existent in its historical documentation in spite of their important roles as fighters, military leaders, and spiritual guides. Revolutionary Women aims to fill this gap. It re-inserts these erased women into the history of the Revolution through telling the stories of Cécile Fatiman, Dédée Bazile, Marie-Jeanne Lamartinière, Victoria "Abdaraya Toya" Montou, and Sanite Bélair. The video installation takes an experimental mixed-media approach to tell their dynamic stories. The five screens …

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The Case Of The Disappearing Owner: Do Dogs Show Behavioral Evidence Of Violation Of Expectation?, Rita Kanagat Jan 2023

The Case Of The Disappearing Owner: Do Dogs Show Behavioral Evidence Of Violation Of Expectation?, Rita Kanagat

Theses and Dissertations

The What the Fluff challenge became a series of viral YouTube videos that started in 2018. In the videos, a person stood behind a blanket in a doorway in front of their dog and lifted and lowered the blanket revealing and obscuring themselves, and finally disappearing with a final blanket drop. The dogs’ reactions were varied but were suggestive of a violation of expectation response. We conducted a community science study that employed methodologies consistent with the What the Fluff Challenge paradigm that were conducted in the owners’ homes with their dogs. Each owner was required to run a control …

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Engineering At-Home Dilution And Filtration Methods To Enable Paper-Based Colorimetric Biosensing In Human Blood With Cell-Free Protein Synthesis, Tyler J. Free, Ryan W. Tucker, Katelyn M. Simonson, Sydney A. Smith, Caleb M. Lindgren, William G. Pitt, Bradley C. Bundy Jan 2023

Engineering At-Home Dilution And Filtration Methods To Enable Paper-Based Colorimetric Biosensing In Human Blood With Cell-Free Protein Synthesis, Tyler J. Free, Ryan W. Tucker, Katelyn M. Simonson, Sydney A. Smith, Caleb M. Lindgren, William G. Pitt, Bradley C. Bundy

Faculty Publications

Diagnostic blood tests can guide the administration of healthcare to save and improve lives. Most clinical biosensing blood tests require a trained technician and specialized equipment to process samples and interpret results, which greatly limits test accessibility. Colorimetric paper-based diagnostics have an equipment-free readout, but raw blood obscures a colorimetric response which has motivated diverse efforts to develop blood sample processing techniques. This work uses inexpensive readily-available materials to engineer user-friendly dilution and filtration methods for blood sample collection and processing to enable a proof-of-concept colorimetric biosensor that is responsive to glutamine in 50 µL blood drop samples in less …

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Full Issue: Summer 2019 Jan 2023

Full Issue: Summer 2019

DePaul Magazine

In this issue of DePaul Magazine, the cover story profiles Scott Ellis, a 1978 graduate of The Theatre School who has made a successful career as a theatre and television director. Learn about his work on the Broadway musical "Tootsie" and more in "Born to Direct."

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Students, Staff To Join Community For Mlk Day Of Service Activities, Edwin B. Smith Jan 2023

Students, Staff To Join Community For Mlk Day Of Service Activities, Edwin B. Smith

University of Mississippi News

Volunteers gathering to honor King's legacy through community engagement

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Book Review: Smokescreen: Debunking Wildfire Myths To Save Our Forests And Climate, Brenda Macías López Jan 2023

Book Review: Smokescreen: Debunking Wildfire Myths To Save Our Forests And Climate, Brenda Macías López

Natural Resources Journal

No abstract provided.

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Protocol For The Phase 2 Edelife Trial Investigating The Efficacy And Safety Of Intra-Amniotic Er004 Administration To Male Subjects With X-Linked Hypohidrotic Ectodermal Dysplasia, Holm Schneider, Smail Hadj-Rabia, Florian Faschingbauer, Christine Bodemer, Dorothy K Grange, Mary E Norton, Riccardo Cavalli, Gianluca Tadini, Holger Stepan, Angus Clarke, Encarna Guillén-Navarro, Sigrun Maier-Wohlfart, Athmane Bouroubi, Florence Porte Jan 2023

Protocol For The Phase 2 Edelife Trial Investigating The Efficacy And Safety Of Intra-Amniotic Er004 Administration To Male Subjects With X-Linked Hypohidrotic Ectodermal Dysplasia, Holm Schneider, Smail Hadj-Rabia, Florian Faschingbauer, Christine Bodemer, Dorothy K Grange, Mary E Norton, Riccardo Cavalli, Gianluca Tadini, Holger Stepan, Angus Clarke, Encarna Guillén-Navarro, Sigrun Maier-Wohlfart, Athmane Bouroubi, Florence Porte

2020-Current year OA Pubs

X-linked hypohidrotic ectodermal dysplasia (XLHED) is a rare genetic disorder characte-rised by abnormal development of the skin and its appendages, such as hair and sweat glands, the teeth, and mucous glands of the airways, resulting in serious, sometimes life-threatening complications like hyperthermia or recurrent respiratory infections. It is caused by pathogenic variants of the ectodysplasin A gene (

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Excretory/Secretory Proteome Of Females And Males Of The Hookworm Ancylostoma Ceylanicum, Samuel C Uzoechi, Bruce A Rosa, Kumar Sachin Singh, Young-Jun Choi, Bethany K Bracken, Paul J Brindley, R Reid Townsend, Robert Sprung, Bin Zhan, Maria-Elena Bottazzi, John M Hawdon, Yide Wong, Alex Loukas, Sergej Djuranovic, Makedonka Mitreva Jan 2023

Excretory/Secretory Proteome Of Females And Males Of The Hookworm Ancylostoma Ceylanicum, Samuel C Uzoechi, Bruce A Rosa, Kumar Sachin Singh, Young-Jun Choi, Bethany K Bracken, Paul J Brindley, R Reid Townsend, Robert Sprung, Bin Zhan, Maria-Elena Bottazzi, John M Hawdon, Yide Wong, Alex Loukas, Sergej Djuranovic, Makedonka Mitreva

Faculty, Staff and Students Publications

The dynamic host-parasite mechanisms underlying hookworm infection establishment and maintenance in mammalian hosts remain poorly understood but are primarily mediated by hookworm’s excretory/secretory products (ESPs), which have a wide spectrum of biological functions. We used ultra-high performance mass spectrometry to comprehensively profile and compare female and male ESPs from the zoonotic human hookworm Ancylostoma ceylanicum, which is a natural parasite of dogs, cats, and humans. We improved the genome annotation, decreasing the number of protein-coding genes by 49% while improving completeness from 92 to 96%. Compared to the previous genome annotation, we detected 11% and 10% more spectra in …

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What Are You Looking At? Emerging Privacy Concerns With Eye Tracking In Virtual Reality, Richard Koch Jan 2023

What Are You Looking At? Emerging Privacy Concerns With Eye Tracking In Virtual Reality, Richard Koch

Colorado Technology Law Journal

No abstract provided.

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Full Issue: Summer 2016 Jan 2023

Full Issue: Summer 2016

DePaul Magazine

This issue of DePaul Magazine recounts the story of alumni Olympian Mabel “Dolly” Staton (EDU ’55) who competed at the 1952 Olympics in Helsinki. Also, learn how DePaul’s Institute for Housing Studies and others examine gentrification in Chicago, find out about DePaul students participating in The Cities Project to help children with the stress of living in urban poverty, and meet alumni who curate exhibitions at museums and galleries.

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Full Issue: Summer 2018 Jan 2023

Full Issue: Summer 2018

DePaul Magazine

The latest issue of DePaul Magazine is now available. In the cover story, see how weathercaster Paul Konrad (THE '87) combines his theatre background and meteorology training as he entertains and informs viewers on WGN-TV Chicago. Get an inside look at his career in "Sunshine State of Mind."

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Full Issue: Summer 2020 Jan 2023

Full Issue: Summer 2020

DePaul Magazine

Concerns about our health have taken center stage in countries around the world. Even before the novel coronavirus emerged, DePaul University was focusing on the need for research and education centered on the health sciences. This issue of DePaul Magazine looks at such timely and urgent topics as traumatic brain injury, nursing, speech language pathology, occupational health and heart disease. It also provides an update on DePaul's response to COVID-19 and the opening of a completely renovated space for opera performance. Please enjoy the summer 2020 issue of DePaul Magazine.

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Antagonistic Effect Of Cyclin-Dependent Kinases And A Calcium-Dependent Phosphatase On Polyglutamine-Expanded Androgen Receptor Toxic Gain Of Function, Diana Piol, Laura Tosatto, Emanuela Zuccaro, Eric N Anderson, Antonella Falconieri, Maria J Polanco, Caterina Marchioretti, Federica Lia, Joseph White, Elisa Bregolin, Giovanni Minervini, Sara Parodi, Xavier Salvatella, Giorgio Arrigoni, Andrea Ballabio, Albert R La Spada, Silvio C E Tosatto, Fabio Sambataro, Diego L Medina, Udai B Pandey, Manuela Basso, Maria Pennuto Jan 2023

Antagonistic Effect Of Cyclin-Dependent Kinases And A Calcium-Dependent Phosphatase On Polyglutamine-Expanded Androgen Receptor Toxic Gain Of Function, Diana Piol, Laura Tosatto, Emanuela Zuccaro, Eric N Anderson, Antonella Falconieri, Maria J Polanco, Caterina Marchioretti, Federica Lia, Joseph White, Elisa Bregolin, Giovanni Minervini, Sara Parodi, Xavier Salvatella, Giorgio Arrigoni, Andrea Ballabio, Albert R La Spada, Silvio C E Tosatto, Fabio Sambataro, Diego L Medina, Udai B Pandey, Manuela Basso, Maria Pennuto

Duncan NRI Faculty and Staff Publications

Spinal and bulbar muscular atrophy is caused by polyglutamine (polyQ) expansions in androgen receptor (AR), generating gain-of-function toxicity that may involve phosphorylation. Using cellular and animal models, we investigated what kinases and phosphatases target polyQ-expanded AR, whether polyQ expansions modify AR phosphorylation, and how this contributes to neurodegeneration. Mass spectrometry showed that polyQ expansions preserve native phosphorylation and increase phosphorylation at conserved sites controlling AR stability and transactivation. In small-molecule screening, we identified that CDC25/CDK2 signaling could enhance AR phosphorylation, and the calcium-sensitive phosphatase calcineurin had opposite effects. Pharmacologic and genetic manipulation of these kinases and phosphatases modified polyQ-expanded AR …

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