Digital Commons Network^™

Evaluation Of Qpcr To Detect Shifts In Population Composition Of The Rhizobial Symbiont Mesorhizobium Japonicum During Serial In Planta Transfers, Kenjiro W. Quides, Yoobeen Lee, Teresa Hur, Hagop S. Atamian

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Microbial symbionts range from mutualistic to commensal to antagonistic. While these roles are distinct in their outcome, they are also fluid in a changing environment. Here, we used the Lotus japonicus–Mesorhizobium japonicum symbiosis to investigate short-term and long-term shifts in population abundance using an effective, fast, and low-cost tracking methodology for M. japonicum. We use quantitative polymerase chain reaction (qPCR) to track previously generated signature-tagged M. japonicum mutants targeting the Tn5 transposon insertion and the flanking gene. We used a highly beneficial wild type and moderately beneficial and non-beneficial mutants of M. japonicum sp. nov. to demonstrate the specificity …

The Grizzly, February 9, 2023, Layla Halterman, Chase Portaro, Marie Sykes, Jagger Clapsadle, Erin Corcoran, Kate I. Foley, Isabel Wesman, Ava Compagnoni

Ursinus College Grizzly Newspaper, 1978 to Present

The Wismer Shuffle • Talking Trash to Address Ursinus' Waste Issue • February Editor's Letter • Ursinus Student Lives It Up, Down Under • Job, Internship and Networking Fair February 15! • Opinions: Pets Banned From Campus Buildings? A-Paw-lling! • "Deal"-ing out Ws • Swim, Swam, Swum in Florida

The Mechanism Of Enantioselective Neurosteroid Actions On Gaba, Hiroki Tateiwa, Satyanarayana M Chintala, Ziwei Chen, Lei Wang, Fatima Amtashar, John Bracamontes, Allison L Germann, Spencer R Pierce, Douglas F Covey, Gustav Akk, Alex S Evers

2020-Current year OA Pubs

The neurosteroid allopregnanolone (ALLO) and pregnanolone (PREG), are equally effective positive allosteric modulators (PAMs) of GABA

Chikungunya Virus And Its Envelope Protein E2 Induce Hyperalgesia In Mice: Inhibition By Anti-E2 Monoclonal Antibodies And By Targeting Trpv1, Carina Z Segato-Vendrameto, Felipe A Pinho-Ribeiro, Et Al.

2020-Current year OA Pubs

Chikungunya virus is an arthropod-borne infectious agent that causes Chikungunya fever disease. About 90% of the infected patients experience intense polyarthralgia, affecting mainly the extremities but also the large joints such as the knees. Chronic disease symptoms persist for months, even after clearance of the virus from the blood. Envelope proteins stimulate the immune response against the Chikungunya virus, becoming an important therapeutic target. We inactivated the Chikungunya virus (iCHIKV) and produced recombinant E2 (rE2) protein and three different types of anti-rE2 monoclonal antibodies. Using these tools, we observed that iCHIKV and rE2 protein induced mechanical hyperalgesia (electronic aesthesiometer test) …

The Student Movement Volume 107 Issue 15: Moving Forward: Au Rings In Black History Month, Anna Pak, Grace No, Nora Martin, Jonathon Woolford-Hunt, Aiko J. Ayala Rios, Andrew Francis, Hannah Cruse, Gloria Oh, Alannah Tjhatra, T Bruggemann, Gabriela Francisco, Elizabeth Getahun, Wambui Karanja, Charisse Lapuebla, Chris Ngugi

The Student Movement v. 107 (2022-2023)

HUMANS

Current Book Reads, Anna Pak

Interview with Kayla Goodman, Lamson Student Dean, Interviewed by: Grace No

Meet Julaine Phillips, BSCF Vice President, Interviewed by: Grace No

ARTS & ENTERTAINMENT

Creatives on Campus: Black History Month, Mora Martin

Currently: You People, Jonathon Woolford-Hunt

Shining Talent at Young Artists Concert 2023, Aiko J. Ayala Rios

NEWS

BSCF's IMPACT Vespers Kicks off Black History Month, Andrew Francis

Death of Tyre Nichols: Catalyst for Change or Recurring Event?, Hannah Cruse

Honors Agape Feast, Gloria Oh

Pre-Vet Club Fundraisers for Stray Cats, Alannah Tjhatra

IDEAS

I Don't Understand Poetry, T Bruggemann

Open AI's Chat …

The Montclarion, February 9, 2023, The Montclarion

The Montclarion

Student Newspaper of Montclair State University

The Cowl - V. 87 N. 11 - February 9, 2023

The Cowl

The Cowl - student newspaper of Providence College. Vol. 87 No. 11 - February, 9, 2023. 28 pages.

Expression Of Malic Enzyme Reveals Subcellular Carbon Partitioning For Storage Reserve Production In Soybeans, Usda Agricultural Research Service, Donald Danforth Plant Science Center, Donald Danforth Plant Science Center, Thomas E. Clemente, Hanh T. Nguyen

Department of Agronomy and Horticulture: Faculty Publications

• Central metabolism produces amino and fatty acids for protein and lipids that establish seed value. Biosynthesis of storage reserves occurs in multiple organelles that exchange central intermediates including two essential metabolites, malate, and pyruvate that are linked by malic enzyme. Malic enzyme can be active in multiple subcellular compartments, partitioning carbon and reducing equivalents for anabolic and catabolic requirements. Prior studies based on isotopic labeling and steady-state metabolic flux analyses indicated malic enzyme provides carbon for fatty acid biosynthesis in plants, though genetic evidence confirming this role is lacking. We hypothesized that increasing malic enzyme flux would alter carbon partitioning …

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Natural Variation In Host Feeding Behaviors Impacts Host Disease And Pathogen Transmission Potential, Alaina C. Pfenning-Butterworth, Rachel E. Vetter, Jessica L. Hite

School of Biological Sciences: Faculty Publications

Animals ranging from mosquitoes to humans often vary their feeding behavior when infected or merely exposed to pathogens. These so-called “sickness behaviors” are part of the innate immune response with many consequences, including avoiding orally transmitted pathogens. Fully understanding the role of this ubiquitous behavior in host defense and pathogen evolution requires a quantitative account of its impact on host and pathogen fitness across environmentally relevant contexts. Here, we use a zooplankton host and fungal pathogen as a case study to ask if infection-mediated feeding behaviors vary across pathogen exposure levels and natural genetic variation in susceptibility to infection. Then, …

Using Research To Save The Anthropocene: A Review Of Michael Quinn Patton’S Blue Marble Evaluation: Premises And Principles, Richard H. Rogers

The Qualitative Report

Patton’s (2020) book, Blue Marble Evaluation: Premises and Principles, will expand your knowledge of evaluation, research, the Anthropocene, global issues, and the planet. In 2023, it is important that we understand the impact of our past and present actions on the planet and the future of humanity. Patton’s principles, supported with comics, figures, and exhibits, will grow evaluators in the knowledge, skills, and mindset to make a positive future difference in our planet and humanity. Methodologists will appreciate a new way to examine evaluation and grow as professionals while professors will have a source to add to their course …

Recovering The Art Of Testimony, As Embodied Within The Historical Black Church, As A Missionally Formative Practice, Christopher Cobbler

DMin Project Theses

This February 2023 Doctor of Ministry project thesis at Lipscomb University aims to consider how the art of testimony, as embodied within the traditional Black church, functions as missionally formative practice. The purpose of this project is to examine the ways testimony service can be utilized to reimagine an alternative eschatological community in a postmodern society. Testimony, in the historical Black Church, was a central component to the life of the congregation; it served as a tool to shape and navigate the theological imagination within a particular community, it cultivated and nurtured centered belonging and was a primary vehicle for …

Nrf2 Sequestration By Ssh1 Tips The Balance From Neuroprotection To Neurodegeneration In Alzheimer’S Disease, Sara G. Cazzaro Buosi

USF Tampa Graduate Theses and Dissertations

Oxidative damage is one of the earliest events in Alzheimer’s disease (AD) pathogenesis and precedes the clinical stage of disease. The nuclear factor erythroid 2-related factor (Nrf2) is activated in response to oxidative stress, which protects the brain from oxidative damage and AD pathogenesis. Although Nrf2-mediated oxidative stress response declines with age and becomes dysfunctional in AD brains, the mechanistic basis for this dysfunction is unknown. Here, we demonstrate through in vitro and in vivo models, as well as in human AD brain tissue, that Slingshot homolog-1 (SSH1) acts as a counterweight to neuroprotective Nrf2 in response to oxidative stress …

Spartan Daily, February 9, 2023, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2023

Volume 160, Issue 7

Compactness And Neutrosophic Topological Space Via Grills, Runu Dhar

Neutrosophic Systems with Applications

The aim of this paper is to introduce the concept of various types of compactness in neutrosophic topological space via grills. We shall generalize neutrosophic C - compact space and neutrosophic G - compact space and introduce C(G) - compact space in neutrosophic topological space with respect to grills. We shall call it as neutrosophic C - compact with respect to grills and term it as neutrosophic C(G) - compact space. We shall also investigate some of its basic properties and characterization theorems. We shall also study the neutrosophic quasi - H - closed space with respect to a grill.

Discovery Of Highly Potent And Bmpr2-Selective Kinase Inhibitors Using Dna-Encoded Chemical Library Screening, Ram K Modukuri, Diana Monsivais, Feng Li, Murugesan Palaniappan, Kurt M Bohren, Zhi Tan, Angela F Ku, Yong Wang, Chandrashekhar Madasu, Jian-Yuan Li, Suni Tang, Gabriella Miklossy, Stephen S Palmer, Damian W Young, Martin M Matzuk

Faculty, Staff and Students Publications

The discovery of monokinase-selective inhibitors for patients is challenging because the 500+ kinases encoded by the human genome share highly conserved catalytic domains. Until now, no selective inhibitors unique for a single transforming growth factor β (TGFβ) family transmembrane receptor kinase, including bone morphogenetic protein receptor type 2 (BMPR2), have been reported. This dearth of receptor-specific kinase inhibitors hinders therapeutic options for skeletal defects and cancer as a result of an overactivated BMP signaling pathway. By screening 4.17 billion “unbiased” and “kinase-biased” DNA-encoded chemical library molecules, we identified hits CDD-1115 and CDD-1431, respectively, that were low-nanomolar selective kinase inhibitors of …

Vista: February 9, 2023, University Of San Diego

USD Vista (1965-)

No abstract provided.

The Kenyon Collegian - February 9, 2023

The Kenyon Collegian

No abstract provided.

Splicing Factor Srsf1 Deficiency In The Liver Triggers Nash-Like Pathology And Cell Death, Waqar Arif, Bhoomika Mathur, Michael F Saikali, Ullas V Chembazhi, Katelyn Toohill, You Jin Song, Qinyu Hao, Saman Karimi, Steven M Blue, Brian A Yee, Eric L Van Nostrand, Sushant Bangru, Grace Guzman, Gene W Yeo, Kannanganattu V Prasanth, Sayeepriyadarshini Anakk, Carolyn L Cummins, Auinash Kalsotra

Faculty, Staff and Students Publications

Regulation of RNA processing contributes profoundly to tissue development and physiology. Here, we report that serine-arginine-rich splicing factor 1 (SRSF1) is essential for hepatocyte function and survival. Although SRSF1 is mainly known for its many roles in mRNA metabolism, it is also crucial for maintaining genome stability. We show that acute liver damage in the setting of targeted SRSF1 deletion in mice is associated with the excessive formation of deleterious RNA-DNA hybrids (R-loops), which induce DNA damage. Combining hepatocyte-specific transcriptome, proteome, and RNA binding analyses, we demonstrate that widespread genotoxic stress following SRSF1 depletion results in global inhibition of mRNA …

Contributors

Marvels & Tales

No abstract provided.

Reviews

Marvels & Tales

The Castle of Truth and Other Revolutionary Tales. (Hermynia Zur Mühlen, ed. and Trans. by Jack Zipes). Reviewed by Anna Kérchy

Clever Maids, Fearless Jacks, and a Cat: Fairy Tales from a Living Oral Tradition. (eds. Anita Best, Martin Lovelace, and Pauline Greenhill). Reviewed by Millie Tullis

The Complete Folktales of A. N. Afanas’ev: Volume III. (eds. Jack V. Haney and Sibelan Forrester). Reviewed by Millie Tullis

Honey on the Page: A Treasury of Yiddish Children’s Literature. (ed. and Trans. Miriam Udel). Reviewed by Veronica Schanoes

Japanese Legends and Folklore: Samurai Tales, Ghost Stories, Legends, Fairy …

How Desirable Is The Medium? Effect Of Point Accumulation Scheme On Consumer Loyalty Toward Reward Program, Eujin Park

Asia Marketing Journal

An accruable point scenario study was applied to examine the effect of the point-accumulation trend (diminishing vs. increasing) and the nominal value (small vs. large) of a medium for repeated consumption on program loyalty. The results showed that both factors affect consumer loyalty toward a reward program. Consumers who received a medium with an increasing accumulation trend and a large nominal value perceived a reward to be more valuable than those who received a diminishing trend and a small nominal value. The results confirmed that a large nominal value or an increasing accumulation trend increased the perception of reward and …

Rules Of Attraction: Females Perception Of Male Self-Representation In A Dating App, Olga Roshchupkina, Olga Kim, Eun-Ju Lee

Asia Marketing Journal

In the current study, we explore how women decide whether to accept or reject a potential match offered by a dating app (Tinder). Specifically, we were trying to identify overlying factors that influence the decision and understand how women make a judgment based on limited cues provided by a Tinder profile. Women largely base their decision on the perceived attractiveness and character of the potential match. The findings suggest that attractiveness is highly subjective, with no universal rules that can be quantified; thus, it is hard to predict acceptance of the potential match. There are however factors that contribute significantly …

Sustainability Of Traditional Retail In An Emerging Market: A Conceptual Framework Applied To A Vietnamese Wet Market, Thi Tuyet Nhung Tran

Asia Marketing Journal

In emerging countries, traditional retail, such as wet markets, still accounts for a large proportion of retail sales. Traditional retail has poor infrastructure compared to modern retail, and is often associated with problems of waste, water, and environmental pollution. Therefore, traditional retail faces extreme difficulties in achieving sustainability. This study aimed to determine what value traditional retail contributes to sustainability. We generated and applied a conceptual framework of sustainability to explore this question. We used a single case study of a small-scale wet market in Vietnam. The results showed that wet markets have significant value for the development of sustainable …

Protocol: New York State Race, Ethnicity, And Insurance Disparities In Follow-Up Prostate Cancer Screening, Seth Greenspan, Mansi Chandra, Hyun Woo Joo, Netanel Sapir, Jonathan Gorman, Jie Yang, Xiaoning Li, Barghav Cavale, Allegra Fierro, Annie Laurie Laurie Shroyer, John P. Fitzgerald

Department of Urology Faculty Publications

Using de-identified reports from the Statewide Planning and Research Cooperative System (SPARCS) data, this descriptive study will identify the impact of socioeconomic status (SES) metrics on the follow-up prostate cancer screening care within 3 years of index prostate cancer screening test in NYS. The socioeconomic status metrics will be subclassified into race, insurance, and ethnicity and each of these sub-components will be evaluated for its impact on the follow-up cancer screening care. The exclusion criteria for this study includes patients records with unknown age, age <55 or >75, previous history of prostate cancer or radical prostatectomy, previous prostate biopsy, female sex, lives …

We Are ... Marshall, February 8, 2023, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

An Updated Classification Of Meditation Methods Using Principles Of Taxonomy And Systematics, Jonathan D. Nash, Andrew B. Newberg

Marcus Institute of Integrative Health Faculty Papers

This paper revisits the proposal for the classification of meditation methods which we introduced in our initial 2013 publication, “Toward a Universal Taxonomy and Definition of Meditation”. At that time, we advanced the thesis that meditation methods could be effectively segregated into three orthogonal categories by integrating the taxonomic principle of functional essentialism and the paradigm of Affect and Cognition; and we presented relevant research findings which supported that assertion. This iteration expands upon those theoretical and methodological elements by articulating a more comprehensive Three Tier Classification System which accounts for the full range of meditation methods; and demonstrates how …

The Concepts Of Law And Morality In Castle In The Sky, Kiet T. Tran

CAFE Symposium 2023

This project examines the film Castle in the Sky by Studio Ghibli, directed by Hayao Miyazaki and how it uses “chaotic good”, “lawless evil” and “lawful good” being ideas rework from Future Boy Conan (1978) also directed by Hayao Miyazaki through an examination of the relationships between the characters.

How Did The Tamagotchi Become A Worldwide Phenomenon, Gianna V. Bona

CAFE Symposium 2023

The Tamagotchi is a popular Japanese toy by Bandai Co that pioneered virtual pets and led other companies to develop virtual toys and games that changed how children and consumers interacted with toys.

Standing Genetic Variation As A Potential Mechanism Of Novel Cave Phenotype Evolution In The Freshwater Isopod, Asellus Aquaticus, Lizet R. Rodas, Serban M. Sarbu, Raluca Bancila, Devon Price, Žiga Fišer, Meredith E. Protas

Natural Sciences and Mathematics | Faculty Scholarship

Novel phenotypes can come about through a variety of mechanisms including standing genetic variation from a founding population. Cave animals are an excellent system in which to study the evolution of novel phenotypes such as loss of pigmentation and eyes. Asellus aquaticus is a freshwater isopod crustacean found in Europe and has both a surface and a cave ecomorph which vary in multiple phenotypic traits. An orange eye phenotype was previously revealed by F2 crosses and backcrosses to the cave parent within two examined Slovenian cave populations. Complete loss of pigmentation, both in eye and body, is epistatic to the …

Senate Meeting, February 8, 2023, Academic Senate

Academic Senate Minutes

No abstract provided.