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Transcription Factors Daf-16/Foxo And Hlh-30/Tfeb Form A Regulatory Axis To Control Tubular Lsysosomes Formation In C. Elegans, Cristian Ricaurte

LSU Doctoral Dissertations

The development of therapies that can be applied in human health care to promote longer and healthier lives is one of the main goals of aging research. However, many of the interventions currently available have serious adverse effects that limit their translational potential. Thus, new strategies are urgently needed to promote healthy aging in humans. Here, we reveal a functional interaction between the insulin signaling pathway and mTOR pathway that promotes healthy aging in C. elegans via lysosomal tubulation. Their respective transcription factors, DAF-16/FOXO and HLH-30/TFEB cooperate, to drive the formation of tubular lysosomes (TLs) under various contexts, which contributes …

Megakaryocyte And Platelet Thrombospondin-1 Regulates Matrix Remodeling By Stabilizing Basement Membrane Col6a1 In Lung Injury, Hernán F Peñaloza, Atish Gheware, Ananya Gupta, Donovan Watza, Anupam Kumari, Zeyu Xiong, Pooja Bhojraj, Jae-Sung Kim, Bo-Ram Jin, Kyunghee Choi, Matthew R Rosengart, Jaehyung Cho, Janet S Lee, Et Al.

2020-Current year OA Pubs

An early event after lung injury is extracellular matrix (ECM) remodeling and the formation of a provisional matrix. While megakaryocytes and platelets (Mgk/plt) play important roles in hemostasis, their impact on the matrix in lung injury is not fully understood. Using lung intravital microscopy, 3D large area scanning with multiphoton confocal hybrid imaging, and label-free quantitative proteomics, the matricellular protein thrombospondin-1 (TSP1) arising from Mgk/plt protects the lung from alveolar injury. Mgk/plt cell-specific Thbs1 knockout (cKO) mice show increased alveolar barrier disruption with exaggerated neutrophil-mediated injury. The cKO mice exhibit striking extracellular matrix re-organization with reduction in basement membrane matrix …

No Effect In Plasma Corticosterone Levels After Observation Of Diseased Conspecifics, B. M. Hardy, M. Chang, S. Mccallum, S. Santangelo, Patricia C. Lopes

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Organisms commonly respond to stressors in their environment by increasing the secretion of corticosterone (CORT). While increased CORT is acknowledged as a response to predation risk by organisms inhabiting a landscape of fear, new research raises the potential for changes in CORT as a response to the risk of infection by organisms in their environment. An increase in CORT of a healthy, uninfected individual in response to their perception of the risk of infection in their environment could change their susceptibility to infection, highlighting a significant role for CORT to alter host–pathogen dynamics. To investigate the effects of infection risk …

Mist: A Hierarchical Bayesian Framework For Detecting Differential Dna Methylation Dynamics In Single-Cell Data, Daoyu Duan, Wenjing Ma, Wen Tang, Hao Wu, Liangliang Zhang, Hao Feng

Faculty, Staff and Student Publications

Recent advancements in single-cell DNA methylation (scDNAm) sequencing technologies have enabled the profiling of epigenetic landscapes at unprecedented resolution, offering insights into cellular heterogeneity, differentiation and evolution. Trajectory inference, which orders cells along pseudotime, allows researchers to track genomics changes across continuous cell states and identify key loci exhibiting differential methylation. However, no methods currently exist to model methylation changes along pseudotime in scDNAm data. Here, we present a hierarchical Bayesian framework for scDNAm data analysis. Our method, named mist (methylation inference for single-cell along trajectory), models stage-specific biological variations, identifies genomic features with significant methylation changes along pseudotime, and …

Pkmζ-Kibra Interactions, Molecular Turnover, And Memory, Changchi Hsieh, David A Cano, Panayiotis Tsokas, James E Cottrell, André Antonio Fenton, Harel Shouval, Todd Charlton Sacktor

Faculty, Staff and Student Publications

How can the molecules that strengthen synaptic connections maintain memory in the face of molecular turnover? Our previous work showed that persistent interaction between the postsynaptic scaffolding protein, KIBRA, and the autonomously active PKC isoform, PKMζ, is crucial for maintaining synaptic long-term potentiation (LTP) and memory lasting at least a month. This duration is longer than the lifespans of individual KIBRA and PKMζ molecules. Biophysical modeling of the interaction suggests oligomers of KIBRA-PKMζ dimers, but not individual dimers or monomers, can overcome molecular turnover by continuously incorporating newly synthesized KIBRA and PKMζ, replacing those that have degraded. Here we used …

The Role Of Autophagy In Intestinal Infection In Mice And C. Elegans, Gowri Kalugotla

Arts & Sciences Graduate Student Theses and Dissertations

Although autophagy, which is the process by which cells reallocate nutrients and eliminate unwanted materials, has been studied for decades, the connections between autophagy, inflammation, and viral immunity are still under investigation. Our studies focus on two genes: murine Epg5, which is involved in fusion of the autophagosome and lysosome, and C. elegans atg-3, which is important for the elongation of the phagophore. Here, we find that Epg5 mutation protects against enteric viruses including norovirus and rotavirus. We identify IFN- responsive genes as a key alteration and observe that Epg5 mutant mice exhibit substantial alterations in the intestinal microbiota. Surprisingly, …

Household Expenditure And Insurance Adoption As Determinants Of Financial Risk In Urban Companion Animal Healthcare, Hong Yun Wu, Chee Vui Wong, Changh Hao Han

Jesselton Journal of Educators and Scholars

Urban households increasingly face financial exposure associated with companion animal healthcare in market-based systems where costs are largely borne out of pocket. This study examines how household expenditure and insurance adoption shape financial risk in urban companion animal healthcare. Using survey data from 500 urban households, the analysis investigates expenditure patterns, predictors of pet insurance adoption, and spatial variation in healthcare spending across urban districts. Regression results show that household income, number of pets owned, educational attainment, and age are significantly associated with variation in annual healthcare expenditure. Logistic regression findings indicate that insurance adoption is driven more by socioeconomic …

Periodontal Disease And Its Association With Porphyromonas Gingivalis: Current Understanding Of Microbial Dysbiosis, Immunopathology And Immune Evasion, Samantha Robins, Alex Strachan, Vehid Salih, Andrew Foey

Peninsula Dental School

Porphyromonas gingivalis is described as a keystone pathogen associated with periodontal disease (PD), which exhibits enhanced representation upon microbial dysbiosis in such a chronic inflammatory disease. This oral pathogen drives and contributes to a dysregulated immune response, resulting in stages of aggressive destructive immune activation and inflammation punctuated by immune suppression, which underlies the relapsing–remitting nature of this disease. The understanding of key mechanisms and balance between protective innate, adaptive immune responses and dysregulated responses, linked to changes in the oral mucosal microbial environment, will afford researchers the potential to manipulate oral mucosal environments for clinical benefit. This review focuses …

In Vivo Hsc Gene Therapy Enables Sustained Ecd4-Ig Expression For Siv Prevention, Chang Li, Anna K Anderson, Anne-Sophie Kuhlmann, Veronica Nelson, Audrey Germond, Hongjie Wang, Aphrodite Georgakopoulou, Sucheol Gil, Jasmin Martinez-Reyes, Andrew Riker, Shruthi Shankar Raman, Jiho Kim, Philip Ng, Donna Palmer, Michael D Alpert, Nickolas Skamangas, Charles Bailey, Tianling Ou, Christine M Fennessey, Michael Farzan, Keith R Jerome, Brandon F Keele, Hans-Peter Kiem, André Lieber, John K Bui

Faculty, Staff and Students Publications

We aim to develop an in vivo hematopoietic stem cell (HSC) gene therapy approach for the prevention and control of HIV-1 infection. Toward this goal, we engineered helper-dependent adenovirus (HDAd) 6/3+ vectors to directly transduce HSCs in vivo, enabling progeny cells to secrete eCD4-Ig, a decoy protein that broadly neutralizes HIV/simian immunodeficiency virus (SIV) isolates by mimicking the primary viral receptor CD4 and coreceptors such as CCR5. In rhesus macaques, the HDAd 6/3+ platform achieved long-term expression of an enhanced eCD4-Ig variant (“eCD4-Ig-Emm06”) that retained potent neutralization efficacy in vivo. Transduced HSCs differentiated into lymphoid and myeloid lineages …

From Protocol To Action: Critical Perspectives On Earthquake Preparedness In Mexico, Sandra Vaiciulyte, David A. Novelo-Casanova, Thalia Anagnos, Gerardo Suárez

Faculty Research, Scholarly, and Creative Activity

Purpose – This study explores perceptions and reactions to earthquake preparedness education, earthquake early warning (EEW) systems and earthquake drill protocols in Mexico, as well as potential strategies to make these earthquake preparedness tools more effective and meaningful. Design/methodology/approach – Eleven Focus Groups were conducted with 109 students from diverse academic and social backgrounds of the two largest public universities in Mexico. The findings were validated on a broader participant group using questionnaires, focused solely on the drill, administered to two populations at two distinct institutions following the 2025 National Earthquake Drill in Mexico City. Findings – Focus group findings …

From Athens To Morocco: Street Dogs And Sports, Andrew Rowan

WellBeing News

Street dogs are a visible feature of many cities, shaping how residents, tourists, and policymakers perceive urban life. This article traces connections between street dog populations, tourism, and major sporting events—from Athens’ experience with international competitions to Morocco’s preparations for global sports hosting—highlighting the ethical, cultural, and policy challenges surrounding humane dog population management. It argues that compassionate, science-based approaches to street dog management are essential for both community wellbeing and a city’s global reputation.

Evolving Animal Welfare Standards In American Veterinary Medicine: Controversies And Challenges, Andrew Rowan

WellBeing News

Veterinary medicine in the United States is evolving from a primary focus on treating disease to a broader commitment to advancing animal welfare. This article explores how science, ethics, and professional standards are shaping the veterinarian’s growing role in promoting animals’ well-being.

Costumes, Connections, And Community: An In-Depth Exploration Of The Dynamics Within The Cosplaying Community, Carlo L. Ortiz, Gabriel Louie Fil Limpin Darang, Danial Mendoza Shomalzadeh, Rodnae Lu Palmito Cayat, Jorge Carle Fontanilla Dacaimat, Carl Rangel Buslayan Dangsi, Alfonso B. Astudillo Iii

DLSU Senior High School Research Congress Conference Proceedings

Cosplay is a fun way to express oneself through costumes and roleplay that has given rise to a vibrant global community. While various studies have explored certain elements of this phenomenon, the cosplay community remains partially unexplored. This research aims to further investigate the dynamics of the cosplay community, providing meaningful insights into the identity processes, motivations, sense of belonging, and creativity that define it. Using in-depth interviews and online questionnaires, the research employs an inductive thematic analysis to examine how cosplayers interact with community-building, creativity, identity, and self-expression. Findings reveal that cosplayers actively engage with these aspects as they …

Undergraduate Research Institute Discovery 2026: Research Abstracts Booklet, Undergraduate Research Institute

Discovery Day - Prescott

No abstract provided.

Investigating Corollaries Between Streptococcus Gallolyticus Subsp. Gallolyticus Virulence And Colorectal Cancer, Tyler G. Myers

Pursuit - The Journal of Undergraduate Research at The University of Tennessee

Streptococcus gallolyticus subsp. gallolyticus (Sgg) is a gram-positive, non-beta-hemolytic bacterium that belongs to the Lancefield group D of streptococcal pathogens. For the past several decades, associations between Sgg bacteremia and colorectal cancer (CRC) have been apparent, with gastroenterologists routinely recommending colonoscopies for positive cases of Sgg in either blood or stool samples. However, current research has not wholly established whether Sgg acts as a causative agent of CRC or if pre-existing cancers make the lumen of the colon more hospitable to its colonization. Regardless, Sgg has been implicated in the modulation of host inflammatory pathways and subsequent remodeling …

The House Of Ai: Intellectual Property Law As It Relates To Generative Ai And Fashion, Abhilasha Praveen

Pursuit - The Journal of Undergraduate Research at The University of Tennessee

Over the past decade, artificial intelligence has permeated nearly every aspect of society, yet American legislation in this field remains largely archaic. The absence of specific legislation governing generative AI in the United States has led to numerous intellectual property (IP) and copyright disputes, infringing on both creator’s rights and discouraging innovation. Given the rapid evolution of generative AI in society, comprehensive legislative action is necessary to establish clear guidelines balancing intellectual property rights with the need for innovation through technological advancement. While this issue spans multiple industries, this article focuses on fashion, examining how AI regulation can foster innovation …

Lsu Health New Orleans School Of Dentistry Welcomes Esperanza Academy For Give Kids A Smile Day

New Orleans Dental Association News

LSU Health New Orleans School of Dentistry (LSUSD) reinforced its long standing commitment to community oral health by welcoming approximately 120 first, second, and third graders from Esperanza Academy for this year’s Give Kids a Smile Day—a national initiative dedicated to expanding access to dental care and oral health education for children

The article showcases the event services, activities, contributors, and fun photos full of costumes.

Noda News March 2026

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.

Interactive Visual Disambiguation For Natural Language Database Queries, Timo Hoyer

Defensive Publications Series

Systems that translate natural language to database queries may encounter challenges with ambiguous terms, for example, 'high-value' or 'recent'. A system for interactive visual disambiguation can visually identify and highlight uncertain terms within a user’s natural language input. A user can interact with a highlighted term to generate a manipulatable graphical tether that connects the term to an interactive logic card. This card may provide controls, such as sliders, for refining the definition of the term. As a user adjusts a definition, a data projection engine can update a data preview in near real-time to illustrate the potential impact of …

The Parthenon, March 11, 2026, Baylee Parsons, Kaitlyn Fleming, Abby Ayes, Ella Hatfield, Davina Synder, Scott Price, Trista Honaker

The Parthenon

No abstract provided.

Genetic Architecture Of The Murine Red Blood Cell Proteome Reveals Central Role Of Hemoglobin Beta Cysteine 93 In Maintaining Redox Balance., Gregory R Keele, Monika Dzieciatkowska, Ariel M Hay, Matthew Vincent, Callan O'Connor, Daniel Stephenson, Julie A Reisz, Travis Nemkov, Kirk C Hansen, Grier P Page, James C Zimring, Gary Churchill, Angelo D'Alessandro

Faculty Research 2026

Red blood cells (RBCs) transport oxygen but accumulate oxidative damage over time, reducing function in vivo and during storage, critical for transfusions. To explore the genetics of RBC resilience, we profiled proteins, metabolites, and lipids from fresh and stored RBCs from 350 genetically diverse mice. Our analysis identified over 6,000 quantitative trait loci (QTLs). Compared to other tissues, the prevalence of trans genetic effects over cis ones reflects the absence of de novo protein synthesis in anucleated RBCs. QTL hotspots at Hbb, Hba, Mon1a, and (storage-specific) Steap3 linked ferroptosis to hemolysis. Proteasome QTLs clustered at multiple loci, underscoring the importance …

Genetic Architecture Of The Murine Red Blood Cell Proteome Reveals Central Role Of Hemoglobin Beta Cysteine 93 In Maintaining Redox Balance., Gregory R Keele, Monika Dzieciatkowska, Ariel M Hay, Matthew Vincent, Callan O'Connor, Daniel Stephenson, Julie A Reisz, Travis Nemkov, Kirk C Hansen, Grier P Page, James C Zimring, Gary Churchill, Angelo D'Alessandro

Faculty Research 2026

Red blood cells (RBCs) transport oxygen but accumulate oxidative damage over time, reducing function in vivo and during storage, critical for transfusions. To explore the genetics of RBC resilience, we profiled proteins, metabolites, and lipids from fresh and stored RBCs from 350 genetically diverse mice. Our analysis identified over 6,000 quantitative trait loci (QTLs). Compared to other tissues, the prevalence of trans genetic effects over cis ones reflects the absence of de novo protein synthesis in anucleated RBCs. QTL hotspots at Hbb, Hba, Mon1a, and (storage-specific) Steap3 linked ferroptosis to hemolysis. Proteasome QTLs clustered at multiple loci, underscoring the importance …

Optimizing Healthcare Utilization: Distinguishing Between Emergency And Urgent Care, Madilyn Calkins, Molly Dupar, Wintana Gherie, Marcin Janczak, Angela Lee, Lena Zhang

Nursing Leadership in Community Engagement Projects

Optimizing Healthcare Utilization: Distinguishing Between Emergency and Urgent Care

Over the past two months, our group of six nursing students worked with a local transitional housing program for families. Per the facility report, a large portion of the program’s current residents are immigrants and have had little to no exposure to the American healthcare system and their options for care. The issue we targeted for our project is the increased number of 911 calls and emergency room (ER) visits for non-emergent healthcare concerns by our target population. By creating education materials on self-triaging, ER vs. Urgent Care services, and how …

The Lumberjack, March 11, 2026

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.

Tunable 3d-Printed Biomaterials For Perfused In Vitro Models Of The Blood-Brain Barrier, Louis Salvatore Paone

Theses and Dissertations

In vitro models have tremendous utility for improving our understanding of complex physiological and pathophysiological processes in a more controlled environment than animal models, in addition to incorporating human cells to overcome species-specific disparities. This dissertation describes innovations in biomaterial-based fabrication processes that advance in vitro models of the blood-brain barrier, providing the opportunity to evaluate the effects of cell-matrix interactions on barrier integrity, additives to reduce viscous drag of blood flow, and molecular mechanisms underlying the cellular response to amyloid beta in the context of Alzheimer’s disease. The core technology underlying this advance is a biomaterial compatible with digital …

100 Years In The Making: The Drive Initiative And A Reorganization Of The Department Of Energy And Natural Resources, Blake Canfield, Tyler Gray, Clay Parker

LSU Journal of Energy Law and Resources

No abstract provided.

Trending Topics And Issues In Mineral Bankruptcy Sales, Chacey R. Malhouitre, Mary Elisabeth Naumann

LSU Journal of Energy Law and Resources

No abstract provided.

Note To Self V. Bpx: Closing The Post-Production Cost Gap In Louisiana's Forced Pooling Laws, Addison A. Jones

LSU Journal of Energy Law and Resources

No abstract provided.

Generative Ai/Machine Learning In The Screen Production Classroom And The Implications For Tertiary Educators., James Thompson, Kereen Ely-Harper, Tom Young, Rachel Wilson, Nico Meissner

Staff Scholarship - Australia & Dubai

This report explores how screen production educators in the ASPERA community are responding to the rapid integration of generative Artificial Intelligence (genAI) in teaching and learning. Framed by Sean Cubitt’s (2020) notion of Common Intelligence, we investigate two guiding questions: How are students engaging with genAI tools in their productions, and what are the implications for educators? Methodologically, we engaged in qualitative professional dialogue with screen practice educators through three mechanisms during the 2024 ASPERA Conference: lightning provocations, an anonymous Mentimeter survey, and a facilitated roundtable discussion. These activities provided a collaborative forum for educators to share practice-based insights, reflect …

Wnt/Β -Catenin Signalling Shapes Macrophage Behaviour During Injury And Repair In The Mouse Submandibular Gland, Araz Ahmed, Suveer Sachdeva, Simon Whawell, Isabelle Miletich

Peninsula Dental School

Xerostomia, the subjective sensation of dry mouth, is a debilitating consequence of head and neck radiotherapy and autoimmune disorders such as Sjögren’s syndrome. It severely impairs oral health and quality of life by promoting mucosal ulceration, infection, malnutrition, and speech difficulties, yet effective regenerative treatments remain limited. Macrophages have recently emerged as critical regulators of salivary gland repair through their roles in coordinating inflammation, fibrosis, and epithelial regeneration; however, the molecular mechanisms governing macrophage activation and function in the injured salivary gland remain poorly defined. The Wnt/β-catenin signalling pathway is a key regulator of inflammation and tissue homeostasis across multiple …