Digital Commons Network^™

Breaking Into Hiv-1'S Epigenetic Vault: Cure Strategies To Eliminate The Viral Reservoir, Joanna Jones, Chelsea Gunderson, Brian Wigdahl, Michael Nonnemacher

Kimmel Cancer Center Faculty Papers

Human immunodeficiency virus type 1 (HIV-1) is a retrovirus that integrates into the host cell's DNA as a provirus. Transcription from the provirus is regulated in large part by cellular proteins and epigenetic factors. These may be repressive or permissive to productive infection. The host factors that regulate this balance are therefore attractive targets for HIV-1 therapeutics. Indeed, proviral chromatin is the focus of two of the current HIV-1 cure strategies. "Shock and Kill" uses latency reversal agents to open the provirus's chromatin, promoting high levels of gene expression that induce the killing of infected cells. "Block and Lock" uses …

Spatiotemporal Patterns Of Occupancy By Pygmy Rabbits (Sylvilagus Idahoensis), Kevin A. Royal, Brock R. Mcmillan, Kimberly A. Hersey, Steven L. Petersen, Randy T. Larsen

Student Works

The pygmy rabbit (Sylvilagus idahoensis) is a species of conservation concern that has declined due to fragmentation and loss of essential habitat, primarily sagebrush-steppe. Pygmy rabbits are currently under review for listing under the U.S. Endangered Species Act (ESA) and consequently require a clearer understanding of current distribution and patterns of occurrence in big sagebrush (Artemisia tridentata) habitats. From 2024 to 2025, we surveyed for pygmy rabbits using remote cameras at several historically occupied sites in Utah, USA, to understand patterns of activity and occupancy. We also compared current estimates of occupancy to historical data collected approximately 20 years ago. …

Characterization Of Hyperoxia-Induced Lung Injury In Adult Female Rats, Abraham G. Taye

Master's Theses (2009 -)

Acute Respiratory Distress Syndrome (ARDS) is a life-threatening lung disease that results from direct or indirect insults to the lung, leading to air-blood barrier damage, pulmonary edema, hypoxemia, and multi-organ failure. Hyperoxia, or exposure to high fractions of oxygen, is used as a life-saving therapy to improve blood oxygenation in patients with ARDS. However, it can also worsen lung injury by inducing excessive production of reactive oxygen species (ROS), primarily from mitochondria, and by contributing to the progression of ARDS. Rat exposure to hyperoxia is a well-established animal model of clinical ARDS that replicates key clinical features. Clinical and preclinical …

“You Are My Tutor, Not My Peer”: Hierarchy In Cross-Cultural Consulting In Writing Centers, Yinan Ding

Purdue Writing Lab/Purdue OWL Graduate Student Presentations

Six cases of tutoring Chinese-speaking students and one case with English-speaking American student are presented to demonstrate students’ perceived hierarchy in tutoring sessions, as well as their different preferences and comfort levels with a hierarchical or peer-tutorial dynamic. Some students often addressed the tutor with the formal “you” in Mandarin Chinese, preferred to call tutors “teachers,” and expressed admiration for tutors' educational background, while English-speaking students occasionally signal hierarchical expectations, suggesting this phenomenon may transcend a single cultural group. To build writing centers as supportive, interconnected ecosystems of learning, it is important to conduct further research on students’ perceptions and …

Rethinking Ubuntu Philosophy In Nigeria's Environmental Law: A Pathway To Sustainable Plastic Pollution Regulation, Ndubuisi Augustine Nwafor

Villanova Environmental Law Journal (1991 - )

No abstract provided.

Sea Changes In Sue-And-Settle Policy: The Tides Of Transparency And Expediency, Evan B. Fitzgerald

Villanova Environmental Law Journal (1991 - )

No abstract provided.

Boots On The Ground, Toxins In The Water: A Look Into The Present State Of Camp Lejeune Water Contamination, Kaitlyn N. Helt

Villanova Environmental Law Journal (1991 - )

No abstract provided.

Employing A Hysteresis Approach To Analyze Shifts In Tree Physiological Thresholds In Response To Drought, Mauro Brum, Annie Deslauriers, Matthew A. Vadeboncoeur, Tanner Frost, David Moore, Caroline Rodrigues Da Silva, Daniel B. Metcalfe, Heidi Asbjornsen

Faculty Publications

Drought‐induced tree mortality underscores the need for improved physiological models to predict tree responses to water stress. We employed a hysteresis modelling approach analyzing diel water absorption and desorption cycles to understand drought‐induced shifts in physiological thresholds. We applied this approach to sap flow (Js), stem diameter fluctuation (SDF), stem volumetric water content fluctuation (SVWCF), and vapour pressure deficit (VPD), datasets from two throughfall reduction experiments in contrasting ecosystems: a cloud forest (Peru) and a temperate forest (USA). Using a generalised transcendental equation, we quantified five diurnal hysteresis loops (Js:VPD, Js:SDF, Js:SVWCF, SDF:VPD, SVWCF:VPD) and derived hysteresis parameters (centroids, area, …

Draft Intermediate (60%) Remedial Design Report Blacktail Creek Riparian Actions Butte Priority Soils Operable Unit Of The Silver Bow Creek/Butte Area Superfund Site Silver Bow County, Montana, Hydrogeologic, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Pinocchio And The Tiny Pink Monkey (2026) | Program, Jacksonville State University

Department of Theatre & Film Performance Archive

Performed: 13-16 March 2026; "Pinocchio and the Tiny Pink Monkey" was written by Michael Boynton and the Members of the Flying Blink Theatre Ensemble. Artistic team were Carolyn Conover (director), Brayden Turner (stage manager), Addie Barnes and Ophelia Lazo (assistant stage managers), Eli Sims (assistant stage manager/tour manager), Corrine Todd (costume designer), Skye Strauss (puppet designer), Cheyenne Oliver (lighting designer), Ryan Godfrey (assistant lighting designer), Mike Long (fight choreographer). Production staff were Cheyenne Oliver (technical director), Ryan Godfrey (run crew), Akira Scott-Crough (light board operator), Liesl Cristy (spotlight operator), Ellie Boozer (costume shop manager), Molly Willingham (wardrobe head), Devin Knight …

The Collective Impact Of Physical Activity, Somatic Therapy, And Nature-Based Spirituality (Pastans) On Individuals Recovering From Substance Use Disorders (Suds), Sara R. Maddox

University Honors Theses

This correlation research study explores the collective impact of physical activities, somatic therapies, and nature-based spirituality (referred to as PASTANS, a term created by the researcher) on individuals recovering from substance use disorders (SUDs). The study aimed to evaluate how these practices enhanced emotional regulation and fostered community development, thereby supporting sustained recovery and overall well-being. PASTANS interconnected to alleviate cravings and rewire brain reward pathways, promoting cultural connections through activities that resonated with pre-colonial traditions and were accessible to atheists and agnostics.

Participants engaged in movement and somatic practices in natural settings, including yoga and hiking. Somatic therapies are …

Glycative Stress Disrupts The Mitochondrial-Lysosome Axis And Promotes Geroconversion In Aging Cardiomyocytes, Diana Bou-Teen, Simonas Valiuska, Elisabet Miro-Casas, Chiara Rubeo, Elena Bonzon-Kulichenko, Zuzana Nichtova, Celia Fernandez-Sanz, Javier Inserte, Antonio Rodriguez-Sinovas, Begoña Benito, Eduard Ródenas-Alesina, Jesús Vázquez, Ignacio Ferreira-González, Marisol Ruiz-Meana

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Aging is a major risk factor for heart failure, yet the molecular mechanisms linking cardiac aging to the inflammatory pathophysiology of heart failure remain elusive. Mitochondrial dysfunction and defective organelle quality control are emerging hallmarks of the aging heart, but their biochemical underpinnings are poorly defined. Using comprehensive glycomics, we found that cardiac mitochondria from physiologically aged mice (≥ 20 months) are the major intracellular reservoirs of advanced glycation end products (AGEs), derived primarily from the chemical attack of some α-oxoaldehydes on proteins. This was associated with mild mitochondrial dysfunction and structural remodeling. Lysosomes in aged hearts were enlarged, more …

Identification And Full Genome Sequencing Of Previously Unknown Sandfly-Borne Phleboviruses Using A Newly Established Capture-Based Next-Generation Sequencing Approach, Edwin O. Ogola, Inga Slothouwer, Gilbert Rotich, Anne Kopp, Armanda D. Bastos, Caroline Getugi, Julia Melchert, Terence C. Jones, Dorcus C. Omoga, Rosemary Sang, Baldwyn Torto, David P. Tchouassi, Sandra Junglen

All Peer-Reviewed Publications

Sandfly-borne phleboviruses cause febrile illness and neuroinvasive disease in humans. While infections are reported in the Mediterranean region, the discovery of previously unknown phleboviruses in sandflies from Kenya suggests a wider geographic distribution. Detection and characterization of novel phleboviruses are often hindered by low-quality and low-viral-load samples. We developed a capture-based target enrichment next-generation sequencing approach that showed a 99%-100% fold enrichment of viral genomes from primary material and provides a robust tool for generating complete genomes of both known and previously unknown viruses. From a collection of 15,652 sandflies in Kenya, we recovered seven complete coding sequences of Embossos, …

Synergistic Microbiome-Peptidome Therapeutics: Exploring Lactobacillus Reuteri Dsmz 17648 And Stem Cell-Derived Peptides For Immunomodulation And Tissue Repair Across Diseases, Hasan M. Agha, Mohammed A. Abdalqader, Abdullah Asad Siddiqui, Shafiq Aazmi, Jantson Hoh, Oh Chin Kin Michelle, Sabaa M. Agha, Amjad Abdulhadi Mohammed, Muneer Mohammed Saleh Alsayadi

AUIQ Complementary Biological System

Chronic inflammatory and degenerative disorders are driven by interconnected immune dysregulation, metabolic instability, epithelial barrier disruption, and impaired tissue repair, limiting the durability of conventional single-target therapies. The global rise in chronic inflammatory, metabolic, and age-related degenerative diseases underscores an urgent need for multi-dimensional therapeutic strategies that move beyond isolated molecular targets. Despite rapid advances in microbiome science and regenerative medicine, these fields have largely evolved in parallel, with limited integration at the translational level. Emerging evidence identifies the gut microbiome as a central regulator of systemic immunometabolic homeostasis through microbial metabolites, barrier integrity modulation, and immune-cell education. In parallel, …

Python Hunting: How Laws That Protect The Everglades From The Invasive Burmese Python, Including Eradication Programs, Can Inform The Regulation Of Objects Controlled By Artificial Intelligence, Kerri Lynn Stone, Joshua Stone

Journal of Technology Law & Policy

This Article explores the surprisingly apt analogy between the Burmese python problem in the Florida Everglades and abandoned objects that are controlled by artificial intelligence (AI). With few natural predators, the invasive Burmese python, which was likely introduced to the Everglades through abandonment by pet owners, has threatened native species with extinction. Objects controlled by AI, which we will likely increasingly share our environment with, such as autonomous taxis and food delivery robots, as well as a variety of objects that are used by the military, may be abandoned by their owners and continue to operate. Over time, these objects …

Land Grant Report 2024-2025, Tennessee. Higher Education Commission.

Land Grant Funding Report

No abstract provided.

Tennessee State Museum Winter 2025 Newsletter & Calendar Of Events, Tennessee. State Museum.

Tennessee State Museum

No abstract provided.

Tennessee State Museum Summer 2025 Newsletter & Calendar Of Events, Tennessee. State Museum.

Tennessee State Museum

No abstract provided.

Tennessee State Museum Spring 2025 Newsletter & Calendar Of Events, Tennessee. State Museum.

Tennessee State Museum

No abstract provided.

Tennessee State Museum Spring 2024 Newsletter & Calendar Of Events, Tennessee. State Museum.

Tennessee State Museum

No abstract provided.

Polyherbal Phytochemicals As Multi-Target Inhibitors Of Key Breast Cancer Proteins: A Computational Approach, Nadia Wahyuningsih, Nashi Widodo, Sri Rahayu, Muhaimin Rifa’I

Karbala International Journal of Modern Science

Breast cancer is a primary worldwide health concern, and conventional therapies often cause side effects. This study was performed to investigate the therapeutic potential of a polyherbal formulation containing Curcuma longa, Phyllanthus niruri, Ziziphus mauritiana, Nigella sativa, and Annona muricata as multi-target inhibitors against breast cancer protein targets using molecular docking and molecular dynamics in silico approach. Bioactive compounds were analyzed using Liquid Chromatography High-Resolution Mass Spectrometry (LC-HRMS) to identify the extract's phytochemicals. The compounds were examined for drug-likeness, membrane permeability, bioactivity, and toxicity. The inhibitory ability against the proto-oncogene pathway, which is commonly dysregulated and mutated in breast cancer, …

The Effectiveness Of Wordwall-Integrated Game-Based Learning On Elementary School Students' Science And Social Studies (Ipas) Learning Outcomes, Maryanah Maryanah, Aynin Mashfufah, Riska Pristiani

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

The implementation of IPAS learning at the elementary school level is still dominated by one-way learning strategies with limited media support. This condition has an impact on the low level of student activity, resulting in suboptimal conceptual understanding, especially for abstract material such as food chains. This study aims to examine the effect of applying digital game-based learning integrated with Wordwall on the IPAS learning outcomes of fifth-grade elementary school students. The research used a quantitative approach with a quasi-experimental design, involving a treatment group and a comparison group with equivalent initial abilities. Data collection was carried out using a …

Spectator 2026-03-12, Editors Of The Spectator

The Spectator

No abstract provided.

Pulpal Chamber Floor Thickness Of First Molars In A Black South African Sample, Marisca Meyer, Casper Jonker, Sandeepa Singh, Federico Foschi, Anna Catherina Oettlé

Peninsula Dental School

Background/Objectives: Root canal procedures on multi-rooted teeth, including first molars, depend on experience, tactile perception, and anatomical knowledge to avoid perforation in the furcation region. Studies using various methodologies and populations have reported discrepant findings on pulpal floor thickness. No study using micro-computed tomography (Micro-CT), the gold standard, has been conducted on a Black South African sample to evaluate pulpal floor thickness. Methods: In this cross-sectional, descriptive,quantitative study, Micro-CT scans of 91 maxillary and 77 mandibular first molars were reconstructed in 3D and oriented according to a reference plane along the cemento-enamel junction using Avizo software. Measurements were taken from …

2026-03-12 As Eduardo Penalver Departs For Georgetown, How Does He Leave Seattle U?, Natalie Schorr, Hadia Noor Ahmed

The Spectator Online

No abstract provided.

Energetic Heterogeneity In Retinal Ganglion Cells: Role Of Neuronal Activity And Implications For Resilience, Zelun Wang

Arts & Sciences Graduate Student Theses and Dissertations

Retinal ganglion cells (RGCs) form the only connection between the eye and the brain via their axons in the optic nerve. In diseases such as glaucoma, RGCs undergo irreversible neurodegeneration leading to vision loss. RGCs consist of multiple types differing in morphology, gene expression, and signaling properties. Moreover, these types exhibit differential survival after axon injury. What cellular properties vary between RGC types that could underlie their heterogeneous response to neurodegeneration? Given that energy metabolism is tightly optimized for the homeostatic and active functions of different neurons, physiologically distinct RGC types likely exhibit divergent energetic characteristics. Furthermore, energy metabolism is …

From Niche To Norm: Plant-Based Labelling Strategies To Shift Social Norms To Support Plant-Based Food Choices, Houkje Adema, Marleen C. Onwezen, Ellen J. Van Loo, Liam Dwyer, Ellen Van Kleef

Department of Agricultural Economics Faculty Publications

Plant-based labels aim to promote plant-based choices by highlighting which products are plant-based. However, these labels are often applied selectively, leaving many more plant-based products unlabelled. We argue that this may unintentionally communicate that plant-based options are more ‘niche’ rather than the ‘norm’, and thereby hinder normalisation of plant-based consumption. Across two incentive-compatible experiments with representative Dutch samples in a simulated online supermarket, we examined how labelling interventions influence perceived availability of plant-based options, descriptive and injunctive social norms for choosing plant-based, and plant-based choices. In Study 1 (N = 1474), we manipulated the number of plant-based products labelled as …

Etv2 Mediated Differentiation Of Human Pluripotent Stem Cells Results In Functional Endothelial Cells For Engineering Advanced Vascularized Microphysiological Models, Shun Zhang, Zhengpeng Wan, Lei Wang, Caihong Wu, Junkai Zhang, Sarah Spitz, Xun Wang, Marie A. Floryan, Mark F. Coughlin, Francesca M. Pramotton, Liling Xu, Ron Weiss, Roger D. Kamm

Michigan Tech Publications

Patient-specific microphysiological models have become a valuable tool for broad applications, revolutionizing biomedical research. However, limitations persist, with functional vasculature being a significant challenge. With the discovery of ETV2's determinant role in specifying EC lineages during differentiation, researchers have adopted techniques involving ETV2 overexpression to produce h-iECs more efficiently and consistently. Here, we generated multiple h-iPSC lines with inducible ETV2 expression, and subsequently differentiated them into h-iECs, which were validated functionally and by key endothelial markers and RNA-seq analysis. These cells are capable of reproducibly self-organizing into stable microvascular networks (MVNs) in a microfluidic chip, forming lumenized and functional vessels …

Ole Miss Bridge Program Equips First Responders With Sensory Kits, Marvis Herring

University of Mississippi News

OXFORD, Miss. – Flashing lights and blaring sirens during an emergency can overwhelm anyone, especially individuals with autism or sensory sensitivities. But a new initiative from the University of Mississippi's Bridge Program aims to help families find comfort when first responders arrive.

Biofilm Architecture Determines Proliferation Of Phages And Plasmids, James B. Winans

Dartmouth College Ph.D Dissertations

This thesis explores how biofilm architecture determines the spread and ecological consequences for the bacteria-dependent genetic elements phages and plasmids. Using Escherichia coli and Vibrio cholerae as model microbes, and the genetic elements T7 phages, λ phages, and conjugative plasmid pED208, we investigate how spatial structure influences phage infection dynamics, plasmid transfer, and interbacterial interactions within biofilms. We show that densely packed biofilms can protect sensitive bacteria from phage exposure and modulate competitive outcomes between obligately lytic and temperate phages. We find that entirely different outcomes can coöccur within microns of each other dependent on biofilm structure. We also demonstrate …