Digital Commons Network^™

Assessment And Contrast The Sustainable Growth Of Various Road Transport Systems Using Intelligent Neutrosophic Multi-Criteria Decision-Making Model, Nada Nabeeh

Sustainable Machine Intelligence Journal

This study analyses the elements and approaches to creating sustainable transport systems, with a focus on road travel. The study examines the environmental and economic aspects of sustainable road transport and stresses the need to curb carbon emissions, boost energy efficiency, clean the air, ensure everyone has easy access to transport, and think about societal goals as a whole. Important considerations including environmental effect, energy efficiency, legislative frameworks, and economic impact are highlighted in the study. The MCDM model is used as a complexity instrument to strike a balance between competing objectives and criteria. This research may help stakeholders use …

Protecting Iot Devices From Botnet Threats: A Federated Machine Learning Solution, Ahmed A. Metwaly, Ibrahim Elhenawy

Sustainable Machine Intelligence Journal

The proliferation of Internet of Things (IoT) devices has brought unprecedented convenience to our lives, but it has also opened the door to new security challenges. One of the most pressing threats in the IoT landscape is the proliferation of BotNets, which can compromise and control a multitude of devices for malicious purposes. In this paper, we propose a novel approach to address this issue: a Federated Machine Learning Solution for BotNet detection in IoT environments. Our method leverages the collective intelligence of distributed IoT devices while respecting privacy constraints, ensuring that sensitive data never leaves the device. We present …

A First-In-Human Phase I Study Of Milademetan, An Mdm2 Inhibitor, In Patients With Advanced Liposarcoma, Solid Tumors, Or Lymphomas, Mrinal M Gounder, Todd M Bauer, Gary K Schwartz, Amy M Weise, Patricia Lorusso, Prasanna Kumar, Ben Tao, Ying Hong, Parul Patel, Yasong Lu, Arnaud Lesegretain, Vijaya G Tirunagaru, Feng Xu, Robert C Doebele, David S Hong

Faculty, Staff and Student Publications

Purpose: This study evaluated the safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy of milademetan, a small-molecule murine double minute-2 (MDM2) inhibitor, in patients with advanced cancers.

Patients and methods: In this first-in-human phase I study, patients with advanced solid tumors or lymphomas received milademetan orally once daily as extended/continuous (days 1-21 or 1-28 every 28 days) or intermittent (days 1-7, or days 1-3 and 15-17 every 28 days) schedules. The primary objective was to determine the recommended phase II dose and schedule. Secondary objectives included tumor response according to standard evaluation criteria. Predefined analyses by tumor type were performed. Safety and …

An Association Between Comorbidities And Postsurgical Complications In Adults Who Underwent Esophagectomy, Rupa Seetharamaiah

All Publications

Background Esophagectomy is the surgical excision of part or all of the esophagus and is associated with both common and serious complications. Various comorbidities, such as diabetes mellitus, smoking, and congestive heart failure (CHF), have been detected in individuals who have undergone esophagectomy. This study investigates the association of baseline characteristics and comorbidities with postoperative complications. Methods A retrospective cohort study based on data from the National Surgical Quality Improvement Program database was conducted, evaluating 2,544 patients who underwent esophagectomy between January 2016 and December 2018. Data included baseline characteristics, established comorbidities, and postoperative complications within 30 days of the …

Patterns And Processes In The History Of Body Size In Turritelline Gastropods, Jurassic To Recent, Carlie Pietsch, Michael Gigliotti, Brendan M. Anderson, Warren D. Allmon

Faculty Research, Scholarly, and Creative Activity

Body size is an important trait with implications for energy use and ecology as well as generation time and evolutionary rates. Turritelline gastropods are widely distributed through geologic time and space, making them an excellent group for evaluating macroevolutionary patterns. To evaluate the pattern of body-size change in turritelline gastropods, we compiled a dataset of shell lengths of 316 species of turritelline gastropods spanning the Jurassic to Recent. Type specimens were almost always significantly larger than specimen distributions from the same species. We found that turritelline gastropod size was inversely correlated with latitude, a trend likely driven by the Neogene-Recent …

The Quantitative Microanalysis Explorer: Introducing Web-Based Visualization For Optical, Electron, And Quantitative X-Ray Maps For Studying Lunar Samples, Angelina Minocha

Senior Honors Papers / Undergraduate Theses

Modern sample imaging techniques produce data in the form of large mosaics, wherein every pixel contains valuable mineralogical information. These heavy data files are challenging for most computers to load and process, furthermore access to lunar and other extraterrestrial samples is limited. We developed the QME Tool to display optical, electron, and quantitative x-ray maps in conjunction with one another to overcome these challenges and advance mineralogy data presentation and analysis. The images and quantitative data was collected using specialized techniques, followed by an extensive image co-registration process. The interface was developed using OpenSeadragon, “An open-source, web-based viewer for high-resolution …

Board Of Pharmacy, Mackenzie Mccoy, Angela O’Hara

California Regulatory Law Reporter

No abstract provided.

Veterinary Medical Board, Dimitri A. Davis, Angela O’Hara

California Regulatory Law Reporter

No abstract provided.

Ecological And Environmental Changes And Protection Measures Of Lakes In China, Ganlin Zhang, Xiaohong Gu, Tao Zhao, Yunlin Zhang, Ligang Xu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Lakes (including artificial reservoirs) are important surface water resources, and they are also an important part of the earth surface system consisting of "mountains, waters, forests, fields, lakes, grassland and desert". Based on the lake survey data and long-term monitoring data collected by the Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences as well as other institutions, this paper systematically analyzed the overall status and long-term trends of the ecological and environmental changes of natural and artificial lakes in China, focused on the ecological and environmental status and changes of typical lakes in the five major lake zones …

Achievement Of Wetland Protection And Restoration And Development Strategies In China, Hui Zhu, Haitao Wu, Xiaoxu Xing, Tian Xie, Changchun Song, Guodong Wang, Ming Jiang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Wetland provides various ecological functions, and wetland protection and restoration directly affect national security, sustainability of economy and society, as well as human well-being. This study has systematically summarized the current status of wetland resource and the achievement of wetland protection in China, and the conclusions will provide scientific support for the policy making in wetland protection and management. The area of wetland in China was 41.2×104 km2 based on remote sensing monitoring in 2020, which lead the first in Asia. Since the 18th National Congress of the Communist Party of China (CPC), the area of wetland has showed a …

Mountain Protection And Mountain Development In China: Review And Prospect, Anbang Wen, Qing Tang, Chaojun Ouyang, Bo Zhu, Yukuan Wang, Ainong Li, Shuai Li, Wanze Zhu, Lijun Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

China is a large mountainous country in the world, where the mountainous area is about two-thirds of the land area. In the past ten years, the coverage rate of mountain forest and grass vegetation has increased by 8.2%, the average value of mountain green coverage index has reached 82.1%, and vegetation coverage has reached the highest value since the founding of the People's Republic of China; The area of water and soil erosion has decreased by 275 000 square kilometers, and the annual soil erosion in mountainous areas has decreased by 27%. At present, the backbone system of mountain ecological …

Accelerating Biosafety Capacity Building To Ensure National Biosecurity, Peipei Liu, Jiafu Jiang, Hao Lu, Peilei Cong, Lilin Zhao, Gexia Qiao, Dongsheng Zhou, Guizhen Wu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Biosafety is an essential part of the national security system, which is related to people's lives and health, the country's longterm stability, and sustainable development, which is the bottom line that must be guaranteed. The international biosafety situation is grim and complex, while domestic biosafety faces challenges. Therefore, biosafety capacity building has become an international hot spot, among which scientific and technological innovation, talent training, and infrastructure platform construction are the top priorities. Although China has achieved strategic results in the rapid identification of pathogens, research, and development of specific vaccines and medicine in fighting against COVID-19 by relying on …

Analysis Of Germany’S Experience On Development Of Biosphere Reserves And Suggestions To China, Yijie Xian, Ning Liu, Na Qiao, Qiang Fang, Qunli Han, Ding Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Germany has integrated biosphere reserves into the national strategy of sustainable development, and has built an outstanding biosphere reserve system nationwide, which has played a key role in maintaining the stability of ecosystem, exploring sustainable use of natural resources, innovating social development models, prospering local economies and providing an important platform to carry out comprehensive research on human and nature relationship. The experience of Germany includes:long and solid accumulation in the development of protected areas; deep understanding from authorities and the folk of the concept of Man and the Biosphere Programme (MAB) and the value of biosphere reserves, and more …

Ecological Impacts Of Climate Change And Adaption Strategies, Xinru Wan, Chaoyuan Cheng, Defeng Bai, Zhibin Zhang

Bulletin of Chinese Academy of Sciences (Chinese Version)

In 2022, The United Nations' Intergovernmental Panel on Climate Change (IPCC) released the Sixth Assessment Report (AR6) of Climate Change 2022:Impact, Adaptation and Vulnerability and China Meteorological Administration issued China Climate Chang Blue Book (2022). This paper presents a brief summary of the assessment report on the ecological impacts of climate change and adaption strategies, and related studies of China by reviewing additional literature. The AR6 report and related studies indicate that the ecological impacts of climate warming are significant, including advancement of phenology, extension of plant growing season; species range shift towards high latitude or elevation, tree line moving …

Adiponectin-Mediated Promotion Of Cd44 Suppresses Diabetic Vascular Inflammatory Effects, Yanru Duan, Shihan Zhang, Yuanyuan Xing, Ye Wu, Wen Zhao, Pinxue Xie, Huina Zhang, Xinxiao Gao, Yanwen Qin, Yajing Wang, Xin-Liang Ma, Yunhui Du, Huirong Liu

Department of Emergency Medicine Faculty Papers

While adiponectin (APN) was known to significantly abolish the diabetic endothelial inflammatory response, the specific mechanisms have yet to be elucidated. Aortic vascular tissues from mice fed normal and high-fat diets (HFD) were analyzed by transcriptome analysis. GO functional annotation showed that APN inhibited vascular endothelial inflammation in an APPL1-dependent manner. We confirmed that activation of the Wnt/β-catenin signaling plays a key role in APN-mediated anti-inflammation. Mechanistically, APN promoted APPL1/reptin complex formation and β-catenin nuclear translocation. Simultaneously, we identified APN promoted the expression of CD44 by activating TCF/LEF in an APPL1-mediated manner. Clinically, the serum levels of APN and CD44 …

Bishops In The Catholic Peace Tradition, Ronald G. Musto

The Journal of Social Encounters

This brief survey takes a historical perspective on the role of Catholic bishops in global peacemaking. Building on my previous work 1 and more recent research, it focuses on the roles of bishop as teacher, ruler, and minister of the sacraments and on the interplay between prophetic protest and institutional authority. It covers the origins of the bishop’s office, the development o f prophetic protest and rule in episcopal peacemaking in the early church and Middle Ages, including the Peace and Truce of God. It then turns to early modern peacemaking and the influence of humanist thinkers on Latin American …

Peace Studies And The Limits To Growth, Selina Gallo-Cruz

The Journal of Social Encounters

150 Peace Studies and the Limits to Growth Selina Gallo-Cruz Scientists have issued increasingly dire warnings about the present and future danger posed by ecological overshoot. Peace scholars’ entrée into this discourse is often through a concern over extractive politics, a central locus for how conflicts are bound up in environmental destruction at the hands of the same industries responsible for ecological decline. Policy and practical responses to the urgent need to scale down production lag behind reality, however, and a global growth-based economy continues to prevail. Here, I explore the dilemmas faced by peace studies scholars who may want …

Subsidiarity: A Central Principle For Justice, Peace, And Sustainability In Mining, Caesar A. Montevecchio

The Journal of Social Encounters

The Catholic social teaching principle of subsidiarity states that problems should be dealt with at the lowest level possible, but the highest level necessary. It attempts to create structures of social power that can best protect the dignity of individuals and families and promote their human flourishing. In the case of mining, subsidiarity would say that the communities impacted by mining need to be centered and empowered to the greatest extent possible, but that the national, regional, and/or global nature of the issues at stake, like climate change, violent conflict, or economic justice, mean that community goals and decisions need …

Displacement Of The Rohingyas Of Myanmar, Land Grabbing, And Extractive Capital, Afroza Anwary

The Journal of Social Encounters

Research on the displacement of the Rohingya from their property has paid little attention to how the government’s land policies encourage various actors to seize that land and extract resources. This research is based on interviews with Rohingya refugees, reports from the United Nations and humanitarian agencies, and published academic work. Economic, social, and political factors are responsible for the displacement of Rohingyas. To argue that a single factor is responsible for their displacement would be incorrect, as research reveals a more complicated interaction of social forces. However, this paper considers the unique dynamics of land grabbing, land laws, ethnic …

The Multiple Paths Of Extraction, Dispossession, And Conflict In Mozambique: From Tete’S Coal Mines To Cabo Delgado’S Lng Projects, Ruy Llera Blanes, Ana Carolina Rodrigues, Euclides Gonçalves

The Journal of Social Encounters

When it comes to extractive processes, conflict, and peacebuilding, the case of Mozambique has recently taken center stage due to the emergence of an Islamic insurgency movement in the liquefied natural gas (LNG) project in its northern province of Cabo Delgado. This is but one part of a complex process of highly conflictual extractivist projects unfolding in the country. In this article, we argue that, beyond the specific case of LNG, there is a logic of continuity and accumulation regarding extraction-related grievances that, over the years, has generated community resentment in natural resource rich areas. Multiple accumulating forms of dispossession …

Introduction - Volume 7, Issue 1, Selina Gallo-Cruz

The Journal of Social Encounters

No abstract provided.

The Impact Of Social Determinants Of Health, Namely Financial Assistance, On Overall Survival In Advanced-Stage Non-Small Cell Lung Cancer Patients., Andreas Bello, Neeharika S. Makani

HPD Articles

PURPOSE: Non-small cell lung cancer (NSCLC) is the most prevalent form of lung cancer. Studies have evaluated the association of social determinants of health (SDH) with outcomes in early-stage NSCLC. These studies have shown statistically and clinically significant associations between overall survival (OS) and other SDH (e.g marital status, educational attainment).The aim of our study was to better understand the role of various SDH on OS in advanced-stage NSCLC patients in a community oncology practice in Florida. Methods: In this retrospective study, 125 patients with stage III and IV NSCLC were identified between January 1, 2014, and December 31, 2018. …

The Great Egg Mystery, Jerry Zezima

Erma Bombeck Writers' Workshop Blog

Why did the chicken cross the road? To lay an egg in my backyard.

Efficient Two-Stage Analysis For Complex Trait Association With Arbitrary Depth Sequencing Data, Zheng Xu, Song Yan, Shuai Yuan, Cong Wu, Sixia Chen, Zifang Guo

School of Computing: Faculty Publications

Sequencing-based genetic association analysis is typically performed by first generating genotype calls from sequence data and then performing association tests on the called genotypes. Standard approaches require accurate genotype calling (GC), which can be achieved either with high sequencing depth (typically available in a small number of individuals) or via computationally intensive multi-sample linkage disequilibrium (LD)-aware methods. We propose a computationally efficient two-stage combination approach for association analysis, in which single-nucleotide polymorphisms (SNPs) are screened in the first stage via a rapid maximum likelihood (ML)-based method on sequence data directly (without first calling genotypes), and then the selected SNPs are …

Ad-Syn-Net: Systematic Identification Of Alzheimer's Disease-Associated Mutation And Co-Mutation Vulnerabilities Via Deep Learning, Xingxin Pan, Zeynep H Coban Akdemir, Ruixuan Gao, Xiaoqian Jiang, Gloria M Sheynkman, Erxi Wu, Jason H Huang, Nidhi Sahni, S Stephen Yi

Faculty, Staff and Student Publications

Alzheimer's disease (AD) is one of the most challenging neurodegenerative diseases because of its complicated and progressive mechanisms, and multiple risk factors. Increasing research evidence demonstrates that genetics may be a key factor responsible for the occurrence of the disease. Although previous reports identified quite a few AD-associated genes, they were mostly limited owing to patient sample size and selection bias. There is a lack of comprehensive research aimed to identify AD-associated risk mutations systematically. to address this challenge, we hereby construct a large-scale AD mutation and co-mutation framework ('AD-Syn-Net'), and propose deep learning models named Deep-SMCI and Deep-CMCI configured …

A Systematic Review Of The Relationship Between Discrimination, Racism And Diabetes Care Outcomes For Black Americans, Sandra B. Anim

College of Science and Health Theses and Dissertations

Background: Disparities in diabetes (DM) risk, care, and complications impact Black communities more than that of their White counterparts. While studies have thoroughly examined the impact discrimination and racism have on DM health disparities, no study has systematically reviewed the literature on the association between discrimination, racism, and DM care and outcomes in Black persons.

Purpose: The purpose of this study was to conduct a systematic review of the literature to examine the association between discrimination, racism, and DM care and outcomes in Black persons. The results of this systematic review will be utilized to guide best practices for this …

Cognitive Sparing In Proton Versus Photon Radiotherapy For Pediatric Brain Tumor Is Associated With White Matter Integrity: An Exploratory Study, Lisa E Mash, Lisa S Kahalley, Kimberly P Raghubar, Naomi J Goodrich-Hunsaker, Tracy J Abildskov, Luz A De Leon, Marianne Macleod, Heather Stancel, Kelley Parsons, Brian Biekman, Nilesh K Desai, David R Grosshans, Arnold C Paulino, Zili D Chu, William E Whitehead, Mehmet Fatih Okcu, Murali Chintagumpala, Elisabeth A Wilde

Faculty, Staff and Student Publications

Radiotherapy for pediatric brain tumors is associated with reduced white matter structural integrity and neurocognitive decline. Superior cognitive outcomes have been reported following proton radiotherapy (PRT) compared to photon radiotherapy (XRT), presumably due to improved sparing of normal brain tissue. This exploratory study examined the relationship between white matter change and late cognitive effects in pediatric brain tumor survivors treated with XRT versus PRT. Pediatric brain tumor survivors treated with XRT (

Web-Based Accountability: An Integration Of Extant Knowledge, Research Gaps And Future Directions, Brandi N. Guidry Hollier, Lise Anne D. Slatten

Journal of the North American Management Society

Because Internet-based technologies are readily used by businesses, research scholars have begun to focus on the specific use of such technology by nonprofit organizations for accountability purposes. A central focus of this paper is to review some of the most significant extant literature on web-based accountability, with particular emphasis on conceptual and empirical studies focusing on the nonprofit sector. Much of this research is situated within the public relations literature, as some of the primary elements of online accountability are directly related to establishing relationships and disclosing information to stakeholders. Finally, this paper presents research gaps and future research propositions …

A Practical Theology Of Created Space: Contextualized Theology For Pastoral Crisis Ministry, Gabriel Fisher

Discernment: Theology and the Practice of Ministry

This is a practical theology of created space that attends to the questions raised by critical incidents and contexts by cultivating dialogue among experiences, beliefs, perceptions, and theology. This confessional approach works from the conviction that God is active and present within our experiences and that we are called to participate in the compassionate ministry of Christ. A created space represents a holding pattern of listening and dialogue where attention is given to the other person’s experiences, beliefs, present concerns, and our own formed center using the resources of spiritual theologies.

Using General Systems Theory As A Business Application Paradigm, Vincent O'Rourke

Journal of the North American Management Society

General Systems Theory (GST) is reviewed as a paradigm for modeling business applications. The theory has been used and abused for over sixty years, oftentimes the subject of scholarly articles written by authors who felt the need to write, especially as GST was the current ‘flavor of the day’, but who hadn’t reviewed the basic literature to learn what the GST concept actually entailed. The GST concept is reviewed, from its original documents, and the history is explored. A section is devoted to reviewing some of the literature that has been published in scholarly journals or books over the decades, …