Digital Commons Network^™

Physiological And Hormonal Effects Of Titanium Dioxide Nanoparticles On Thyroid Function And The Impact On Bodyweight In Male Rats, Noori Mohammed Luaibi, Raghda Ali Mohammed

Baghdad Science Journal

Fifty-four Sprague-Dawley albino adult male rats were classified into three main groups each of 18 rats treated for a particular duration (1,2, and 4) weeks respectively. Each group was subdivided into three subgroups each of six rats treated as follows; group (1) serve as normal control, group (2, and 3) intra-peritoneal treated with TiO2NPs (50,200) mg/kg respectively, body *weight of all rats was measured before and after the experiment, then rats were dissected at the end of each experiment and the weights of the thyroid was measured. The result showed a highly significant decrease (p<0.01) in thyroid gland weight, a highly significant increase (p<0.01) in body weights and TSH, while a highly significant decrease (p<0.01) inT3 and T4 was observed in all different doses (50,200) mg/kg at durations 1,2 and 4 weeks. So, this study confirms body weight gain is associated with thyroid dysfunction.

Neurodevelopmental And Transient Impacts Of Brain Kynurenic Acid Elevation And Sleep-Wake Behavior, Katherine Rentschler

Theses and Dissertations

Sleep is vital for healthy cognition and mood. Sleep dysregulation is implicated in psychiatric disorders such as schizophrenia and bipolar disorder. Sex differences in sleep and arousal dysregulation are prominent in patients with psychotic disorders. Elevated levels of the neuroactive tryptophan metabolite, kynurenic acid (KYNA), have been found in cerebrospinal fluid and postmortem brain tissue samples from patients with psychotic disorders. KYNA is an astrocyte derived antagonist at N-methyl-D-aspartate (NMDA) glutamate receptors and α7 nicotinic acetylcholine (α7nACh) receptors. KYNA is synthesized in the brain from its biological precursor, kynurenine, via the enzyme kynurenine aminotransferase II (KAT II), a potential therapeutic …

Governance Of Drug Development Alliances, Devashish Chandrashekhar Thakar

Theses and Dissertations

Innovative biotechnology firms (hereafter, biotechs or biotech firms) consider drug development alliances with incumbent pharmaceutical firms (hereafter, pharmas or pharma firms) as a means to access complementary commercialization capabilities, enhance their managerial skillset through close interactions, and maintain financial stability. However, biotechs face challenges in designing and developing alliance contracts that (a) enable them to retain and refine valuable alliance assets and (b) ensure that the alliance makes tangible scientific progress. Designing contracts to achieve these dual purposes is therefore a salient concern for the biotechs.

Given these challenges, the first essay of this dissertation explores the factors driving the …

Connecting Their Stories: Black Educators’ Experiences Within Cultural Heritage Institutions That Document The Long Arc Of The Civil Rights Movement, Constance Marie Caddell

Theses and Dissertations

This study aims to examine Black educators’ experiences within cultural heritage institutions that are documenting topics that include the long arc of the American Civil Rights Movement. Black educators are powerful conduits of the African American story because they align with African American cultural heritage institution’s goals to foster equality, identity, pride, and honor in the community. These shared goals lead to Black educators using teaching methods that liberate, advocate, and empower students. This allows them to share new knowledge, strategies, techniques, and concepts on diverse topics. Considering their fundamental mission, it is essential to gain an awareness of the …

Impact Of Virtual Models On Students’ Multilevel Understanding Of An Organic Reaction, Eli Martin

Theses and Dissertations

As the number of STEM opportunities and the need for a scientifically literate society increases, educators in STEM fields require tools that help support these needs. Chemistry is one STEM content area that would benefit from exploring educational technology that supports conceptual understanding. An action research study was conducted to understand how students engage with the content and virtual representation to develop their understanding of a chemical reaction. This convergent mixed methods study looked at the effect of dynamic virtual molecular representation on students' ability to understand a reaction mechanism at the symbolic and subparticulate level by measuring content knowledge …

Fourth-Grade And Fifth-Grade Cover-Band Classes: An Action-Research Project Inspired By Popular Music Education And Music Learning Theory, Julia Turner

Theses and Dissertations

I facilitated “Fourth-Grade and Fifth-Grade Cover-Band Classes,” a popular music education-, informal music learning-, and music learning theory-inspired action-research project. The purpose of this action-research project was to examine the facilitation and learning processes used by my students and me when engaged with those music learning approaches and theory. The guiding questions for this study included: 1) How do I use and adapt principles from modern band (2023), Green (2008; 2014), and Gordon (2012; 2013) to prepare my facilitation of a popular music project for my fourth-grade and fifth-grade students? and 2) How do my fourth-grade and fifth-grade students engage …

The Impact Of The Flipped Classroom Model On Elementary Students’ Achievement And Motivation For Learning Geometry, Kimberly M. Smalls

Theses and Dissertations

National and state data show students in poverty perform lower on math standardized assessments than their peers who are not students in poverty. The purpose of this action research was to evaluate the implementation of the flipped classroom model on the achievement and motivation towards mathematics for fourth-grade students at an elementary school in the Southeast United States. Traditional teaching methods such as teacher-led modeling, the use of manipulatives, and small-group math instruction present barriers which have not led to overall academic improvement for these students. This study focused on three overarching questions: (1) Is there a difference in fourth-grade …

Genomic Analysis Of Exophiala Sp. Etnp2018, A Marine Fungal Strain Isolated From An Oxygen Minimum Zone, Margaret Kelly Bernish

Theses and Dissertations

Microbial metabolic activity is central to biogeochemical cycling in virtually all ecosystems. Fungi are important parts of microbial communities, serving as decomposers, parasites, and symbionts. Most of our understanding of fungal ecology is derived from the study of isolated, cultured terrestrial fungi. However, the marine environment includes thousands of divergent, uncultured fungi. A number of these species, which include saprobes, parasites, and endophytes, can survive and sporulate in a wide range of salinities. Other such species face the additional challenge of limited nutrient accessibility. The genus Exophiala includes agents of mycoses in both humans and in marine animals. This research …

Risk Propensity In Journalists: An Analysis Of Journalists’ Personality Traits And How They Direct Behavior In The Field, Ellen Katherine Dunn

Theses and Dissertations

Much like first responders, journalists run toward dangerous scenes instead of away from them, often putting themselves at risk. Unlike first responders, there is no research on a how a person’s risk propensity ties to their career. For this project, reporters of various ages and tenures were surveyed on their sensation-seeking levels and propensity to engage in risky behaviors while working as journalists. Journalism risk propensity correlated positively with sensation seeking. Risk motivations increase with age and tenure, meaning that older and more experienced journalists are more likely to engage in risky behavior. Males are more risk-prone than females. The …

Exploration Into The Relationship Between Colitis And Depression: A Potential Role For The Aryl Hydrocarbon Receptor, Kasie Lynn Roark

Theses and Dissertations

Inflammatory Bowel Disease (IBD) is a group of chronic gastrointestinal disorders with unclear etiology comprised of two defined disorders – Crohn’s Disease (CD) and Ulcerative Colitis (UC). IBD leads to chronic pain, socially isolating symptoms, and an overall reduction in patient quality of life. There is currently no cure for IBD. Due to decreased mucous production and weakening of the colonic epithelial lining, gut-microbiota and their metabolites can invade the intestinal lamina propria and circulate systemically, a term known as “leaky gut”. Recent studies show a relationship exists between peripheral inflammation, such as IBD, and depression. The gut-brain axis (GBA) …

Implementation Of Digital Flashcards To Increase Content-Specific Vocabulary Knowledge And Perceptions Of Motivation And Self-Efficacy In An Eleventh-Grade U.S. History Course: An Action Research Study, Jill Lee Steinmeyer

Theses and Dissertations

Text- and document-dependent courses like high school U.S. History require students to have strong content literacy and vocabulary skills. Traditionally, content-area courses neglect vocabulary skills and those that do address vocabulary often teach words in isolation without context. Students needing more content comprehension skills frequently need more motivation and higher self-efficacy.

Three research questions were used to evaluate the impact of digital flashcards on learning content-specific vocabulary and student perceptions in an eleventh-grade U.S. History course: (a) How and to what extent do digital flashcards affect eleventh-grade U.S. History students’ learning content-specific vocabulary knowledge?; (b) How and to what extent …

Symphony No. V: Elements (Julie Giroux, 2018); An Overview Of Programmatic Elements And Performance Devices, Zackery Augustus Deininger

Theses and Dissertations

Julie Giroux is a multi-faceted composer who has been writing for the wind band since the 1980s. Having composed and arranged over 125 works for wind band, Giroux has dedicated her compositional career to furthering the development of the wind band repertoire while simultaneously working to establish the wind band genre as an area of serious artistic merit. Giroux is in constant demand as a commissioned composer. Her projects are often commissioned by distinguished ensembles, both in the United States and around the world, and many of her pieces receive performances at significant events such as The Midwest Clinic Band …

Nature As Culture: Ecofeminist Narratives Of Environmental And Colonial History, Sydney Leimbach

Theses and Dissertations

“Nature as Culture: Ecofeminist Narratives of Environmental and Colonial History” is a cross-cultural, comparative, feminist investigation of two films, The Nightingale and Wolfwalkers, and two books, The Giving Tree and The Overstory. The narratives are analyzed through a combination of ecofeminism and decolonial feminism, revealing the four narratives’ investment in the effects of colonization on the environment. The two chapters explore the association of women with nature, traditionally used as a subordinating position, instead as a condition of empathetic understanding with both the colonized and the environment. Further, these narratives use the association of women with nature as …

Aortopathies: Mechanism Of Pathogenesis And Therapy, Mengistu G. Gebere

Theses and Dissertations

The aorta is the largest artery in the body which is directly connected to the left ventricle of the heart and functions as an elastic conduit that transports the ejected blood from the left ventricle to peripheral vessels. There are three layers to the aortic wall, tunica intima, tunica media, and tunica adventitia. The tunica media, the thickest middle layer, is composed of vascular smooth muscle cells (SMC) and the extracellular matrix (ECM) as its essential components. SMCs are circumferentially arranged and embedded in elastic lamellae. They are responsible for producing and maintaining/remodeling the extracellular matrix of the aortic media. …

Targeting Macrophages In Cancer Models Using Natural Compounds, Sierra Jordan Mcdonald

Theses and Dissertations

Cancer remains a leading cause of death worldwide. More specifically, breast cancer (BrCa) and colorectal cancer (CRC) continue to be the most diagnosed cancers and leading causes of cancer-related death worldwide. Given that surgery followed by adjuvant chemotherapy is only effective in 20% of CRC patients, and that there are no preventive agents for BrCa metastasis for hormone receptor negative patients, more effective agents and strategies are needed in both the prevention and treatment of these cancers. As one of the most abundant immune cells in the tumor microenvironment, macrophages help regulate primary tumor growth, angiogenesis, and metastasis in many …

Kurt Vonnegut, A Difficult Feminist: Investigating Female Characters In Bluebeard, Matthew Steven Medl

Theses and Dissertations

After a brief contextualization of Vonnegut’s work, this essay close-reads his 1987 novel, Bluebeard, and locates the feminism within. I argue that Vonnegut establishes women as agents of generative change, breakers of marital conventions, artistic sages, authors, expressionists, interlopers, and nonviolent activists. I primarily examine Circe Berman and Marilee Kemp, supplementing with evidence from Edith Taft and Dorothy, as well as wider scholarship.

Biochemical, Structural, And Immunological Characterization Of Selected Panallergens, Andrea Leigh O'Malley

Theses and Dissertations

Allergies throughout the world are increasing in prevalence and severity. Although the direct causes of the development of allergies are not confirmed, study of proteins that cause reactions will lead to a deeper understanding of allergy. This work focuses on three panallergen families, profilins, parvalbumins, and arginine kinases, to further elucidate the background of allergy from the point of view of the allergens themselves. In Chapter 1, we evaluate pollen, fruit, and mite profilins in the context of allergy, showing the relevance of conserved cysteine residues in stability and oligomerization as well as the first data on cross-reactivity between plant …

Redbird Scholar, Vol. 8, No. 2 (Spring 2023), Illinois State University, Office Of The Vice President For Research And Graduate Studies

Redbird Scholar

No abstract provided.

A Holistic Approach To Post-Traumatic Stress Disorder: Alpha-2 Adrenergic Receptor-Sinophilin Cofilin Axis Biologic Antibody Treatment Proposal, Ashley S. Graham

Selected Honors Theses

PTSD affects about 5% of adults in the United States every year.1 This thesis investigates the common biologic therapies for PTSD and the specificity factor of the catecholamine binding to related norepinephrine alpha-2A adrenergic receptors. The binding of these catecholamines to adrenaline receptors in the spinophilin cofilin axis of the dorsal hippocampus causes fear-memory modulation and storage by altering dendritic morphology and thus manipulating neuronal plasticity. Targeting the inhibition of these respective receptors and increasing the activity of cofilin, a protein responsible for breaking down actin utilized for dendrite reaction to stimulus appears promising. By preventing the binding of catecholamines …

A Systematic Literature Review Of Mobile Applications To Assist People With Mild To Moderate Dementia In Their Daily Lives, Zehang Cheng, Kamal Sabran

Malaysian Journal of Computing (MJoC)

The popularity of smartphones has made mobile apps an essential tool for people in managing their daily lives. Helping people with dementia to make good use of mobile apps can reduce the stress on the patient's family and society. Mild and moderate dementia can be eliminated Mild and moderate dementia may be mitigated through simple teaching and human-centered design approaches that accommodate individuals with difficulty using mobile apps. This paper aims to identify the functionality and usability of mobile apps for people with dementia by reviewing mobile apps that assist people with mild to moderate dementia in their daily lives. …

Effect Of Fishmeal Replacement With Dried Red Wigglers (Eisenia Fetida) Worm Meal On Growth And Feed Utilization, Production Efficiency, And Serum Biochemistry In Nile Tilapia (Oreochromis Niloticus) Fingerlings, Youssra M. El-Ouny, Sahya Maulu, Mohamed A.A. Zaki, Amira A. Helaly, Abdel Aziz M. Nour, Mohammed F. Elbasuini, Eman M.H. Labib, Riad H. Khalil, Ali H. Gouda, Amira A.A. Hessein, Marc Verdegem, Hala S. Khalil

School of Biological and Marine Sciences

This study investigated the effect of replacing fishmeal with red wigglers (Eisenia fetida) worm meal (RWWM) in the diet of Nile tilapia (Oreochromis niloticus) fingerlings. Red wigglers worms (RWW) were culture on a vegetable by-product medium, harvested and dried to obtain red wigglers worm meal. The fish (average weight ± SE: 7.70 ± 0.06 g) were fed with seven diets (30% crude protein and 7.5% crude lipid), in which fishmeal was replaced with 0%, 5%, 10%, 15%, 20%, 25%, and 30% RWWM. The fish was reared in 1000 L fiberglass tanks in a recirculating aquaculture system and were hand-fed twice …

Self-Reported Intake Of High-Fat And High-Sugar Diet Is Not Associated With Cognitive Stability And Flexibility In Healthy Men, Hendrik Hartmann, Lieneke K. Janssen, Nadine Herzog, Filip Morys, Daniel Fängström, Sean J. Fallon, Annette Horstmann

School of Psychology

No abstract provided.

Modeling Immune System Dynamics During Hiv Infection And Treatment With Differential Equations, Nicole Rychagov

CODEE Journal

An inquiry-based project that discusses immune system dynamics during HIV infection using differential equations is presented. The complex interactions between healthy T-cells, latently infected T-cells, actively infected T-cells, and the HIV virus are modeled using four nonlinear differential equations. The model is adapted to simulate long term HIV dynamics, including the AIDS state, and is used to simulate the long term effects of the traditional antiretroviral therapy (ART). The model is also used to test viral rebound over time of combined application of ART and a new drug that blocks the reactivation of the viral genome in the infected cells …

Evidence That The Inner Nuclear Membrane Is A Functional Β1-Adrenergic Receptor Signaling Platform In Astrocytes, Kelsey Benton

Dissertations (1934 -)

The noradrenergic system exerts powerful modulatory influences over fundamental brain processes including attention, arousal, learning, and memory by activating adrenergic receptors on neuronal and glial cells. In addition to triggering rapid, transient changes in cellular physiology that drive short-term behavioral actions, these G-protein-coupled receptors also initiate delayed, long-lasting changes in cellular function by regulating gene expression. For example, in astrocytes, norepinephrine-induced activation of β-adrenergic receptors (β-ARs) rapidly induces glucose mobilization from glycogen stores, while simultaneously initiating delayed changes in the expression of glycogen storage genes. Regulation of gene expression requires adrenergic receptor-initiated intracellular signals to reach the nuclear compartment. To …

Altered Motivation & Dopamine Subcircuit Plasticity Unique To Sex During Protracted Opioid Withdrawal, Devan Marc Gomez

Dissertations (1934 -)

Opioid use disorder (OUD) is associated with enduring psychological withdrawal symptoms believed to contribute to drug abuse. Amongst these are shifts in motivational states, wherein pursuit of drug consumption exceeds that of non-drug rewards, reinforcing escalated opioid use and relapse vulnerability. A critical regulator of behavioral reinforcement, the mesoaccumbal dopamine system is thought to be both necessary and sufficient for opioid motivation. However, previous research into its involvement in opioid withdrawal has been limited to acute rather than protracted timepoints, global neuroadaptations rather than those in subcircuits, and overwhelmingly focused on males over females. Using a rodent model of self-administration …

Those Who Came Before: Learning From Native American College Alumni About Walking The Path Of Persistence, Jacqueline Schram

Dissertations (1934 -)

The very low college success rate of American Indians and Alaska Natives has inspired a scholarly literature that seeks to explain this outcome and, more recently, to account for why some Native students persist in college. Few studies, however, look at Native students who actually have graduated from college, and these rarely reflect Native voices or examine the life histories of Indigenous students. To achieve a broader understanding of successful educational trajectories, this qualitative exploration moves beyond the category of students currently attending college and examines the lives of five Indigenous Marquette University alumni. Employing an archival oral history method …

Milton’S Learning: Complementarity And Difference In Paradise Lost, Peter Spaulding

Dissertations (1934 -)

When we consider, in the vein of Golda Werman’s Milton and Midrash, the idea of Milton’s Paradise Lost as self-consciously responding to the Bible, the question of why he makes the changes and additions that he does comes to the fore. This dissertation explores the middle books of Paradise Lost as Milton’s midrashic interventions that, among other things, emphasize the presence of education in the Garden. These scenes shed some light on Milton’s own views of education. Specifically, these interventions show a theory of education that conceives of difference as non-combative, a distinctly non-Hobbesian view of difference. Using Aristotle’s four …

Evaluating The Impact Of Land Use Changes, Drivers Of Tmdl Development, And Green Infrastructure On Stream Impairments, Charitha Jayasri Gunawardana

Dissertations (1934 -)

Despite the water quality improvements and regulatory advancements over the last 50 years since the enactment of the Clean Water Act, water bodies within the United States are still impaired for a broad range of contaminants from non-point source pollution. Improving watershed management approaches to meet this challenge will require a greater understanding of (1) how changes within a watershed, such as changing land use, impact stream water quality, (2) what influence socioeconomic, spatial and political factors may have on the progress towards meeting water quality goals, such as those set within Total Maximum Daily Loads (TMDLs), and (3) how …

Neuronal Glutamate Transporters Modulate Reward-Based Behaviors In Mice, Corey Nilon

Biological Sciences

Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder characterized by uncontrollable, intrusive thoughts (obsessions), restlessness, and repetitive behaviors (compulsions). One of the genes associated with OCD encodes the neuronal glutamate transporter EAAC1. EAAC1 is expressed in the striatum, the main input nucleus of the basal ganglia, implicated with reward, which shows patterns of hyperactivity in patients with OCD. What remains unknown is how EAAC1 contributes to the different behavioral abnormalities of OCD. To address this question, we performed a set of behavioral tests in EAAC1-/- mice. Specifically, we asked how the execution of repetitive reward-based behaviors changed in these mice. Our …

A Design, Development, And Evaluation Of Bio-Patch For Myocardial Tissue Repair, Yaya Zhang

Theses and Dissertations (ETD)

Introduction. Ischemic heart disease (IHD) is a major concern of human health issue. The structural repair and functional recovery of injured hearts is a major challenge in the clinical setting. Preclinical studies over last 10 years have demonstrated the potential of using stem cells to treat IHD, but the efficacy of this therapy is jeopardized by uncontrollable migration and low survival of the injected stem cells. An approach based on tissue engineering enabling target-specific stem cell delivery such as cardiac patches has emerged as an alternative solution for stem cell therapy for IHD. It employs scaffold materials to engulf various …