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Spartan Daily, March 17, 2026, San Jose State University, School Of Journalism And Mass Communications Mar 2026

Spartan Daily, March 17, 2026, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2026

Volume 166, Issue 23


Whole-Blood, Concentrated, And Micro–Dose Del Nido Cardioplegia In Adult Cardiac Surgery: A Scoping Review, Christian Iulianelli Mar 2026

Whole-Blood, Concentrated, And Micro–Dose Del Nido Cardioplegia In Adult Cardiac Surgery: A Scoping Review, Christian Iulianelli

Student Works

  1. A.     Background/Introduction: Del Nido cardioplegia was originally developed for pediatric cardiac surgery to provide prolonged myocardial protection with a single-dose strategy. Its adoption in adult cardiac surgery has led to multiple modified formulations, including whole-blood, concentrated, and bloodless strategies. Given expanding clinical use and variation in technique, a structured mapping of the adult evidence base is warranted.
  2. B.     Methodology: This scoping review followed PRISMA-ScR guidance. PubMed and CINAHL were searched, yielding 88 records. After duplicate removal and screening, 18 studies met inclusion criteria. Data were charted on study design, cardioplegia formulation, patient population, myocardial biomarkers, arrhythmias, renal outcomes, transfusion requirements, …


Understanding The Rising Popularity Of (Un)Religious Pilgrims: Belonging Without Believing, Gregory Smith Mar 2026

Understanding The Rising Popularity Of (Un)Religious Pilgrims: Belonging Without Believing, Gregory Smith

International Journal of Religious Tourism and Pilgrimage

While researchers are in agreement about the positive relationship between spiritual activities (SAs) and mental health (MH) among the general population, the relationship between spiritual tourism (ST) and MH, particularly among young adults, is yet to be adequately investigated. As such, important questions regarding the status of religion in the contemporary world can be addressed through the study of current pilgrimage trends. A ‘pilgrimage boom’ is occurring in Britain and other parts of the global anglosphere (Williams, 2020 & O’Keeffe, 2022). Yet, many of these modern pilgrims do not identify with established religious categories (i.e., Christianity). Significant gaps in our …


The Journey Of The Soul In Aboriginal Australia, Ian S. Mcintosh Mar 2026

The Journey Of The Soul In Aboriginal Australia, Ian S. Mcintosh

International Journal of Religious Tourism and Pilgrimage

For the past decade, I have been studying pilgrimage in all its dimensions in what my colleagues and I have been calling a kaleidoscopic inquiry (McIntosh et al., 2024). In my current investigations, I have been exploring the journey of the soul upon the death of its host. My focus in this working paper is the myths and traditions of the Yolngu Indigenous peoples of northeast Arnhemland in remote northern Australia with whom I lived and worked in the 1980s and 90s. The Yolngu go to great lengths to prepare the dying for their ultimate journey, painting the body with …


The Link March 17, 2026, Access To Justice Institute Mar 2026

The Link March 17, 2026, Access To Justice Institute

The Link Newsletter

No abstract provided.


Carroll County Advisory Council March 2026 Meeting Minutes, Extension Mar 2026

Carroll County Advisory Council March 2026 Meeting Minutes, Extension

Advisory Council

No abstract provided.


Fungal Meningitis In Us Patients Who Received Epidural Anesthesia In Matamoros, Mexico, Dallas J Smith, Elizabeth Misas, Jeremy A W Gold, Nicole Evert, Thi Dang, Emilie Prot, Simone Godwin, Julieanna Rivas, Jessica Pearson, Lori Koenecke, Nirma D Bustamante, Maria Julia Marinissen, Gabriel Garcia Rodriquez, Irma López-Martínez, Caitlyn Lutfy, Samantha Williams, Axel A Vazquez Deida, Katrina M Byrd, Julian A Villalba, Sarah Reagan-Steiner, Lindsay Parnell, Lalitha Gade, Romney M Humphries, Nathan P Wiederhold, Charles Y Chiu, Joshua A Lieberman, Anastasia P Litvintseva, Tom Chiller, Luis Ostrosky-Zeichner, Fungal Meningitis Response Team Mar 2026

Fungal Meningitis In Us Patients Who Received Epidural Anesthesia In Matamoros, Mexico, Dallas J Smith, Elizabeth Misas, Jeremy A W Gold, Nicole Evert, Thi Dang, Emilie Prot, Simone Godwin, Julieanna Rivas, Jessica Pearson, Lori Koenecke, Nirma D Bustamante, Maria Julia Marinissen, Gabriel Garcia Rodriquez, Irma López-Martínez, Caitlyn Lutfy, Samantha Williams, Axel A Vazquez Deida, Katrina M Byrd, Julian A Villalba, Sarah Reagan-Steiner, Lindsay Parnell, Lalitha Gade, Romney M Humphries, Nathan P Wiederhold, Charles Y Chiu, Joshua A Lieberman, Anastasia P Litvintseva, Tom Chiller, Luis Ostrosky-Zeichner, Fungal Meningitis Response Team

Faculty, Staff and Student Publications

Background: Fungal meningitis outbreaks are rare and entail high mortality rates. Beginning May 2023, we investigated fungal meningitis caused by Fusarium solani species complex occurring in US patients who received epidural anesthesia in Matamoros, Mexico.

Methods: Early epidemiological information suggested US patients with suspected fungal meningitis had undergone mostly cosmetic procedures under epidural anesthesia performed in 2 Matamoros clinics. US patients known to have received surgery at these clinics during 1 January-13 May 2023 (clinic closures date) were identified and notified by public health officials. Epidemiological and clinical data were used to update diagnostic and clinical guidance for outbreak response, …


Is The Long-Horned Grasshopper Ruspolia Differens (Orthoptera: Tettigoniidae) A Novel, Nutritious, Functional, And Safe Alternative Food Product? A Review, Margaret Kababu, Collins Mweresa, Dorothy Nakimbugwe, Geoffrey Ssepuuya, Karlmax Rutaro, Nicodemus Matojo, Faith Nyamu, Robert Mbeche, Sevgan Subramanian, Sunday Ekesi, Chrysantus Tanga Mar 2026

Is The Long-Horned Grasshopper Ruspolia Differens (Orthoptera: Tettigoniidae) A Novel, Nutritious, Functional, And Safe Alternative Food Product? A Review, Margaret Kababu, Collins Mweresa, Dorothy Nakimbugwe, Geoffrey Ssepuuya, Karlmax Rutaro, Nicodemus Matojo, Faith Nyamu, Robert Mbeche, Sevgan Subramanian, Sunday Ekesi, Chrysantus Tanga

All Peer-Reviewed Publications

Ruspolia differens Serville (Orthoptera: Tettigoniidae) is among the most widely consumed edible insect in Eastern and Central Africa, where it contributes to both household nutrition and income generation. As a nutrient-dense food source, it offers a promising alternative to curb food insecurity and malnutrition. Despite this, the consumption and use of the grasshopper is limited to its seasonal availability when it is collected from the wild. Coupled with this, is limited evidence on its domestication despite research advances to optimize conditions for mass production. This review was conducted to highlight research advances and gaps on production, processing, nutritional profile, and …


The Prospector, March 17, 2026, Utep Student Publications Mar 2026

The Prospector, March 17, 2026, Utep Student Publications

The Prospector

No abstract provided.


Hsp90 Inhibitor In Reducing Integrated Stress Response In An Experimental Mouse Model Of Spinal Cord Injury, Yousef Abozaid, Aditya Sarkar, Lukasz P. Slomnicki, Michal Hetman Mar 2026

Hsp90 Inhibitor In Reducing Integrated Stress Response In An Experimental Mouse Model Of Spinal Cord Injury, Yousef Abozaid, Aditya Sarkar, Lukasz P. Slomnicki, Michal Hetman

The Cardinal Edge

Spinal cord injury (SCI) initiates a complex cascade of molecular events, including protein misfolding and neuroinflammation, contributing to neural damage and impaired functional recovery. Heat Shock Protein 90 (HSP90), a critical molecular chaperone involved in cellular stress responses, emerges as a promising therapeutic target to mitigate secondary damage after SCI. This study was designed to validate the in-vivo effects of different doses of HSP90 inhibitor, HSP990-i, administered acutely after moderate T9 SCI mouse model. The level of HSP70 protein level is measured through western blot from the injury epicenter. Adult mice underwent experimental contusive SCI at the T9 level, followed …


Urban Areas Are Associated With Earlier Breeding Timing In American Robins, Lola Hackle, Jennifer Wickes, Elise Mittlestat, Ashley Stine, Keegan Abeson, Carolina Villalona, Mikus Abolins-Abols Mar 2026

Urban Areas Are Associated With Earlier Breeding Timing In American Robins, Lola Hackle, Jennifer Wickes, Elise Mittlestat, Ashley Stine, Keegan Abeson, Carolina Villalona, Mikus Abolins-Abols

The Cardinal Edge

Climate change and urban environment have been shown to affect bird reproductive timing. In particular, urban development can create the so-called “heat islands” – urban areas that are hotter than the surrounding environment. While the primary cue birds use to time their reproduction is daylength, birds also use temperature as a supplementary cue to fine-tune their reproductive timing. Change in the timing of breeding may impact the survivability of nestlings due to temperature fluctuations and food availability. The American Robin (Turdus migratorius) is a widespread songbird in North American cities and rural areas. We sought to see if urban heating …


Leaf Droppage Delayed In Sugar Maple Trees On An Urban To Rural Gradient, Isabella S. Bastien, Isabella Bastien Mar 2026

Leaf Droppage Delayed In Sugar Maple Trees On An Urban To Rural Gradient, Isabella S. Bastien, Isabella Bastien

The Cardinal Edge

This study investigates the timing of leaf abscission in Sugar Maple (Acer saccharum) trees along an urban-to-rural gradient in Louisville, Kentucky, to determine how proximity to urban environments influences leaf drop. We hypothesized that urban trees would retain their leaves longer than suburban or rural trees due to environmental stressors and tested this using weekly leaf collection and canopy cover measurements from three locations—urban, suburban, and rural. Results showed that urban trees exhibited delayed leaf drop and slower canopy opening compared to suburban and rural trees. These findings suggest that urban stressors significantly alter tree phenology, which may signal underlying …


Asimina Triloba (L.) Dunal: The Complete Story Of America’S Forgotten Fruit, Autumn M. Howard Mar 2026

Asimina Triloba (L.) Dunal: The Complete Story Of America’S Forgotten Fruit, Autumn M. Howard

The Cardinal Edge

Asimina triloba, commonly known as the pawpaw, is a unique and historically significant native fruit tree of the eastern United States. This research paper explores the taxonomy, botanical description, distribution, habitat requirements, ecological interactions, economic importance, and reproductive biology of A. triloba. The species is distinguished by its tropical-flavored fruits, adaptation to temperate climates, and reliance on clonal reproduction and specific insect pollinators. While offering promising opportunities for sustainable agriculture and riparian restoration, A. triloba faces challenges related to limited seed dispersal, susceptibility to certain pests and diseases, and the presence of neurotoxic compounds. Despite its historical importance …


Full Issue - Mend V.4, Project Mend Mar 2026

Full Issue - Mend V.4, Project Mend

Mend

No abstract provided.


When I Think Of Freedom…, Alexis Kirkpatrick Mar 2026

When I Think Of Freedom…, Alexis Kirkpatrick

Mend

No abstract provided.


Contributors - Mend V.4, Project Mend Mar 2026

Contributors - Mend V.4, Project Mend

Mend

No abstract provided.


History Does Not Repeat Itself, But It Often Rhymes: Comparing The Messaging Of Adolf Hitler And Donald Trump, Elaina Varney Mar 2026

History Does Not Repeat Itself, But It Often Rhymes: Comparing The Messaging Of Adolf Hitler And Donald Trump, Elaina Varney

Scholarly Horizons: University of Minnesota, Morris Undergraduate Journal

With the growing divide between the left and right, many on the left have raised alarms that Donald Trump is a fascist. My research paper compares Donald Trump’s messaging to Adolf Hitler’s messaging to find any similarities between the two in order to determine if Trumpism is a precursor to fascism. This study begins by looking at previous scholars’ research into whether or not Trumpism is a precursor to fascism and then I proceed to draw on primary sources such as speeches, Mein Kampf, and Trump’s TruthSocial posts, particularly those related to immigration and minorities, attacks on and suppression …


When Women Weep: The Gendered Politics Of Lamenting And Death In Early Irish Literature, Catherine Van Wey Mar 2026

When Women Weep: The Gendered Politics Of Lamenting And Death In Early Irish Literature, Catherine Van Wey

Scholarly Horizons: University of Minnesota, Morris Undergraduate Journal

Early Irish literature of the ninth through thirteenth centuries encodes gendered assumptions about women’s emotion through narratives in which grief, sorrow, and shame repeatedly lead to female death. Focusing on the thirteenth-century hagiographic text Tales of the Elders of Ireland, feminist standpoint theory is applied to reveal how male-dominated authorship shapes literary portrayals of women as emotionally excessive, dependent on men, and narratively expendable once those men are lost. Situated within the cultural tradition of female lamentation or caoineadh, these portrayals show how women’s ritual roles as mourners were mythologized and reworked into literary mechanisms that reinforce patriarchal authority. Within …


Early Detection Of Agrilus Planipennis Using Environmental Dna, Hannah Ferguson, Blythe Layton, Matt P. Mills Mar 2026

Early Detection Of Agrilus Planipennis Using Environmental Dna, Hannah Ferguson, Blythe Layton, Matt P. Mills

Urban Ecosystem Research Consortium of Portland/Vancouver

As a recent pest to Oregon, Agrilus planipennis (Emerald Ash Borer, EAB) stands to decimate native ash tree stands, as it has throughout Eastern USA. As shown in common garden studies, Oregon Ash is extremely susceptible to EAB with expected mortality rates of 99% (Herms 2015). EAB infestations are cryptic, and traditional monitoring relies on advanced infestations and costly tree girdling and bark peeling, resulting in appropriate responses lagging the leading edge of the infestation. Environmental DNA (eDNA), the practice of collecting and identifying traces of DNA left in an environmental sample, is a promising tool for early infestation detection …


Gci Invention #258-B: Whirlybird V3.0 – High-Wind Autorotating Fire Suppression & Nutrient Delivery System, Michael Victor Caldwell Mr. Mar 2026

Gci Invention #258-B: Whirlybird V3.0 – High-Wind Autorotating Fire Suppression & Nutrient Delivery System, Michael Victor Caldwell Mr.

Defensive Publications Series

GCI Invention #258-B describes WHIRLYBIRD v3.0, a passive boundary-layer controlled (PBLC) autorotating samara-wing system for ballistic delivery of fire suppressants and precision nutrients in 70+ mph crosswind conditions.

Aerodynamics: Asymmetric high-camber samara wing with spanwise-zoned vortex-grate perforations (root/mid/tip density gradient), geometric twist, and tip micro-tabs for stable LEV, TSR ≈2.2, and 550-650 RPM autorotation. Chordwise stiffness gradient enables passive gust-load shedding (FoS ≥2.5 ultimate, ≥1.5 fatigue). Central high-inertia core provides gyroscopic stability.

Dispersal: RPM-altitude dual-trigger centrifugal release (550-650 RPM + 15m AGL) with internal vanes for 15m uniform ground coverage. Hybrid pellets (outer Purple-K for flame knockdown + inner MAP/polyphosphate …


Gci Universal Acoustic Access Platform (Uaap V1.0): Modular System For Acoustic Access Research Using Phantom Models, Michael Victor Caldwell Mr. Mar 2026

Gci Universal Acoustic Access Platform (Uaap V1.0): Modular System For Acoustic Access Research Using Phantom Models, Michael Victor Caldwell Mr.

Defensive Publications Series

This disclosure describes the GCI Universal Acoustic Access Platform (UAAP v1.0), a modular research system designed to evaluate acoustic access strategies using phantoms and non‑biological analogs. The platform integrates:

  1. Acoustic Window Modules that explore impedance‑matching concepts using gels, water layers, and controlled aerosol layers;

  2. An Active Organ‑on‑Chip Laboratory using low‑absorption polymer microfluidics and vortex‑enhanced flow channels; and

  3. A Smart Beam Tracker that predicts phantom motion and adjusts transducer alignment in real time.

The UAAP platform enables engineers and researchers to study acoustic transmission through bone‑like materials, air‑gap phantoms, and tissue‑mimicking gels. This disclosure provides system architecture, materials, phantom …


Using Passive Camera Monitoring To Investigate Northern Red-Legged Frog Use Of A New Road Undercrossing Structure, Alyson W. Yates, Catherine De Rivera, Susan Barnes, Rachel Wheat, Justine Brumm Mar 2026

Using Passive Camera Monitoring To Investigate Northern Red-Legged Frog Use Of A New Road Undercrossing Structure, Alyson W. Yates, Catherine De Rivera, Susan Barnes, Rachel Wheat, Justine Brumm

Urban Ecosystem Research Consortium of Portland/Vancouver

Northern Red-legged Frogs (Rana aurora) make seasonal movements between lentic waters and adjacent upland forests to meet their life history requirements. This movement behavior makes the species particularly vulnerable to landscape fragmentation by roads, where traffic can cause large mortality events during the breeding period. To mitigate R. aurora mortality on U.S. Route 30 near Burlington, Oregon, an under-road wildlife crossing structure was installed by the Oregon Department of Fish and Wildlife and other partners in late 2024, reconnecting a forested public recreation area with protected wetland habitat in the floodplain of the Willamette River.

We used two specialized optical …


Proceedings Of The 24th Annual Urban Ecology & Conservation Symposium March 16, 2026, Urban Ecosystem Research Consortium Of Portland/Vancouver Mar 2026

Proceedings Of The 24th Annual Urban Ecology & Conservation Symposium March 16, 2026, Urban Ecosystem Research Consortium Of Portland/Vancouver

Urban Ecosystem Research Consortium of Portland/Vancouver

These proceedings document the agenda and abstracts for presentations and posters from the 24th annual conference organized by the Urban Ecosystem Research Consortium of Portland/Vancouver (UERC) which occurred on March 16, 2026. The UERC is a consortium of people from various universities and colleges, state and federal agencies, local governments, non-profit organizations and independent professionals interested in supporting urban ecosystem research and creating an information-sharing network of people that collect and use ecological data in the Portland/Vancouver area. The annual conference has an open call for abstracts. The UERC organizing committee selects the final oral and poster presentations, along with …


Faculty Senate Executive Committee Minutes March 16, 2026, Utah State University Mar 2026

Faculty Senate Executive Committee Minutes March 16, 2026, Utah State University

Faculty Senate & Faculty Senate Executive Committee

  • Call to Order
  • Approval of Minutes
  • University Business
  • Faculty Senate Business
  • Reports
  • Budget and Faculty Welfare
  • Faculty Development and Educational Leadership
  • Sustainability Council
  • Information
  • EPC Report
  • Center for Civic Excellence
  • Employee Benefits
  • Task Force Report
  • Additional Business
  • 2026-2027 Faculty Senate Calendar
  • Adjourn: 4:41 PM


Within Sacred Walls: Cloister Architecture And The Virgin Mary As The Hortus Conclusus In 14th- And 15th-Century Italian Art, Catherine Howard Mar 2026

Within Sacred Walls: Cloister Architecture And The Virgin Mary As The Hortus Conclusus In 14th- And 15th-Century Italian Art, Catherine Howard

Undergraduate Honors Theses

The practice of cloistering allows women to exist in spaces dedicated to meditation and religious devotion. The physical nature of the cloister, which involves walls separating these religious women from the world, maintains a distinction between the cloister as spiritual and the world as secular.

One of the many titles of the Virgin Mary is the hortus conclusus, or “walled garden.” This metaphor is intended to emphasize her spiritual separation from the sins of the world, as well as her perpetual virginity. Artistic depictions of the Virgin in this role, particularly from Italy in the 14th and 15th centuries, often …


Faculty Senate Executive Committee Agenda March 16, 2026, Utah State University Mar 2026

Faculty Senate Executive Committee Agenda March 16, 2026, Utah State University

Faculty Senate & Faculty Senate Executive Committee

  • 3:00 Call to Order
  • Approval of Minutes February 17, 2026
  • 3:05 University Business
  • 3:20 Faculty Senate Business
  • 3:35 Reports
  • Budget and Faculty Welfare
  • Faculty Development and Educational Leadership
  • Sustainability Council
  • 3:55 Information
  • EPC Report - March 5, 2026
  • Employee Benefits
  • Task Force Report
  • 4:15 Additional Business
  • 2026-2027 Faculty Senate Calendar
  • Adjourn: 4:30 pm


The Impact Of The Legalization Of Marijuana On The Under 21 In New Jersey, Sharon Mesmer Mar 2026

The Impact Of The Legalization Of Marijuana On The Under 21 In New Jersey, Sharon Mesmer

Child and Family Law Journal

No abstract provided.


Integrative Multiomic Classification Reveals Distinct Origins And Evolutionary Trajectories Of Thymic Epithelial Tumors., Seongyeol Park, Kijong Yi, Jieun Lee, Myung Jin Yang, Joo-Hye Song, Joonoh Lim, Taewoo Kim, Seokhwi Kim, Su Yeon Kim, Hyung-Don Kim, Yoon Ho Kim, Sae Bom Lee, Yoo Jin Jung, Hansol Park, Jake June-Koo Lee, Yohan An, Jeonghwan Youk, Kwon Joong Na, Samina Park, Hyun Joo Lee, In Kyu Park, Chang Hyun Kang, Eui-Cheol Shin, Tae Min Kim, Won Do Heo, Charles Lee, Gou Young Koh, Sung-Yup Cho, Young Seok Ju, Young Tae Kim Mar 2026

Integrative Multiomic Classification Reveals Distinct Origins And Evolutionary Trajectories Of Thymic Epithelial Tumors., Seongyeol Park, Kijong Yi, Jieun Lee, Myung Jin Yang, Joo-Hye Song, Joonoh Lim, Taewoo Kim, Seokhwi Kim, Su Yeon Kim, Hyung-Don Kim, Yoon Ho Kim, Sae Bom Lee, Yoo Jin Jung, Hansol Park, Jake June-Koo Lee, Yohan An, Jeonghwan Youk, Kwon Joong Na, Samina Park, Hyun Joo Lee, In Kyu Park, Chang Hyun Kang, Eui-Cheol Shin, Tae Min Kim, Won Do Heo, Charles Lee, Gou Young Koh, Sung-Yup Cho, Young Seok Ju, Young Tae Kim

Faculty Research 2026

Thymic epithelial tumors (TET), comprising various histologic types of thymomas and thymic carcinomas, originate from thymic epithelial cells (TEC). Each histologic type is typically associated with a distinct immune cell composition and clinical manifestation. A better understanding of the cellular origins and molecular pathways underlying this heterogeneity is needed to improve patient stratification and treatment. In this study, we conducted an integrated genomic and transcriptomic analysis of 124 thymomas and 13 thymic carcinomas, including 20 newly sequenced cases, combined with 117 cases from publicly available datasets. Single-cell transcriptomic data from murine thymic tissues across developmental stages were incorporated to further …


Short-Term Sleep Restriction In Humans Alters Diurnal Circulating Metabolite Profiles, Including Those Of Microbial Origin., Vanessa A Leone, Katya Frazier, Manpreet Kaur, Evan A Chrisler, Ashley M Sidebottom, Ethan Tai, Vilinh Tran, Shuzhao Li, Eugene B Chang, Dean P Jones, Eve Van Cauter, Erin C Hanlon Mar 2026

Short-Term Sleep Restriction In Humans Alters Diurnal Circulating Metabolite Profiles, Including Those Of Microbial Origin., Vanessa A Leone, Katya Frazier, Manpreet Kaur, Evan A Chrisler, Ashley M Sidebottom, Ethan Tai, Vilinh Tran, Shuzhao Li, Eugene B Chang, Dean P Jones, Eve Van Cauter, Erin C Hanlon

Faculty Research 2026

BACKGROUND. Gut microbes and their metabolites contribute to the host circulating metabolome and exhibit diurnal variation influenced by sleep-wake cycles and meal timing. Sleep deprivation alters the rhythmic circulating metabolome, but its impact on microbial metabolites remains unclear. We tested whether 24-hour circulating metabolite profiles, including those of microbial origin, differ under normal (habitual) versus short-term restricted sleep.

METHODS. In a randomized crossover design, 9 healthy adults completed 2 in-lab 24-hour blood sampling sessions (q120): one following 3 nights of normal sleep (8.5 hours/night), the other following 3 nights of sleep restriction (4.5 hours/night). Meal timing and caloric intake were …


Short-Term Sleep Restriction In Humans Alters Diurnal Circulating Metabolite Profiles, Including Those Of Microbial Origin., Vanessa A Leone, Katya Frazier, Manpreet Kaur, Evan A Chrisler, Ashley M Sidebottom, Ethan Tai, Vilinh Tran, Shuzhao Li, Eugene B Chang, Dean P Jones, Eve Van Cauter, Erin C Hanlon Mar 2026

Short-Term Sleep Restriction In Humans Alters Diurnal Circulating Metabolite Profiles, Including Those Of Microbial Origin., Vanessa A Leone, Katya Frazier, Manpreet Kaur, Evan A Chrisler, Ashley M Sidebottom, Ethan Tai, Vilinh Tran, Shuzhao Li, Eugene B Chang, Dean P Jones, Eve Van Cauter, Erin C Hanlon

Faculty Research 2026

BACKGROUNDGut microbes and their metabolites contribute to the host circulating metabolome and exhibit diurnal variation influenced by sleep-wake cycles and meal timing. Sleep deprivation alters the rhythmic circulating metabolome, but its impact on microbial metabolites remains unclear. We tested whether 24-hour circulating metabolite profiles, including those of microbial origin, differ under normal (habitual) versus short-term restricted sleep.METHODSIn a randomized crossover design, 9 healthy adults completed 2 in-lab 24-hour blood sampling sessions (q120): one following 3 nights of normal sleep (8.5 hours/night), the other following 3 nights of sleep restriction (4.5 hours/night). Meal timing and caloric intake were held constant. Serum …