Digital Commons Network^™

Integrative Multiomic Classification Reveals Distinct Origins And Evolutionary Trajectories Of Thymic Epithelial Tumors., Seongyeol Park, Kijong Yi, Jieun Lee, Myung Jin Yang, Joo-Hye Song, Joonoh Lim, Taewoo Kim, Seokhwi Kim, Su Yeon Kim, Hyung-Don Kim, Yoon Ho Kim, Sae Bom Lee, Yoo Jin Jung, Hansol Park, Jake June-Koo Lee, Yohan An, Jeonghwan Youk, Kwon Joong Na, Samina Park, Hyun Joo Lee, In Kyu Park, Chang Hyun Kang, Eui-Cheol Shin, Tae Min Kim, Won Do Heo, Charles Lee, Gou Young Koh, Sung-Yup Cho, Young Seok Ju, Young Tae Kim

Faculty Research 2026

Thymic epithelial tumors (TET), comprising various histologic types of thymomas and thymic carcinomas, originate from thymic epithelial cells (TEC). Each histologic type is typically associated with a distinct immune cell composition and clinical manifestation. A better understanding of the cellular origins and molecular pathways underlying this heterogeneity is needed to improve patient stratification and treatment. In this study, we conducted an integrated genomic and transcriptomic analysis of 124 thymomas and 13 thymic carcinomas, including 20 newly sequenced cases, combined with 117 cases from publicly available datasets. Single-cell transcriptomic data from murine thymic tissues across developmental stages were incorporated to further …

Tennessee State Museum Spring 2026 Newsletter & Calendar Of Events, Tennessee. State Museum.

Tennessee State Museum

No abstract provided.

Fostering Audiation In Band Through Modeling Videos, Zachary T. Larsen

Undergraduate Honors Theses

Within band classrooms, teachers have a dual responsibility to nurture students’ growth on their primary instrument and cultivate their ability to audiate. While established pedagogical traditions effectively support the teaching of primary instruments, comparable frameworks for cultivating audiation in band settings remain underdeveloped. This project provides band teachers with scaffolded modeling videos designed to bridge this pedagogical gap and support students' development of audiation.

Buffered Strength: A Narrative Review Of Beta-Alanine Supplementation In Weightlifting And Resistance Training, Ian Brunson

Undergraduate Honors Theses

Beta-alanine is a non-essential amino acid synthesized endogenously through hepatic metabolism of uracil and obtained in small amounts from dietary sources. In skeletal muscle, beta-alanine combines with histidine to form carnosine, a dipeptide that functions as an intracellular buffer. Beta-alanine is commonly used as a dietary supplement and is frequently included in pre-workout formulations as an ergogenic aid for high-intensity exercise. Beta-alanine supplementation increases intramuscular carnosine concentrations, which may enhance intracellular buffering capacity by regulating hydrogen ion accumulation and delaying fatigue during intense activity.^1,2 Although much research has examined beta-alanine supplementation in endurance, sprinting, and repeated high-intensity exercise contexts …

Defining The Early Temporal Window Of Cerebellar Motor Memory Consolidation In Mice, Benji Nixon

Undergraduate Honors Theses

The vestibulo-ocular reflex (VOR), a cerebellum-dependent reflex that stabilizes gaze during head movement, provides a powerful model for studying motor learning and memory consolidation. The time-dependent process by which short-term memories become stabilized for long-term storage and are gradually redistributed to other brain regions, enabling retention even after damage to the site of early learning. In mice, motor skill memory deficits can be observed as early as four hours post-training, highlighting that systems consolidation varies in timing and extent across reflexes. This thesis examines the time course of motor memory consolidation in the VOR by examining repeated trainings, presented to …

Targeting Il-1 Signaling In Recessive Dystrophic Epidermolysis Bullosa: Improved Survival And Pathogenesis In Rdeb Mouse Model, Rahim Hirani

NYMC Student Theses and Dissertations

Recessive dystrophic epidermolysis bullosa (RDEB) is a devastating inherited blistering disorder caused by biallelic mutations in COL7A1, resulting in deficiency of type VII collagen (C7) and loss of dermal–epidermal adhesion. Beyond mechanical fragility, RDEB is characterized by chronic inflammation, progressive fibrosis, impaired wound healing, severe pain, and an exceptionally high risk of aggressive cutaneous squamous cell carcinoma. Emerging transcriptomic and cytokine profiling studies have identified interleukin-1 alpha (IL-1α) as a dominant and temporally upstream inflammatory mediator in RDEB skin. The central hypothesis of this dissertation is that IL-1α signaling functions as a key initiator and amplifier of inflammation-driven pathology …

The Story Of Belonging: A Rhetorical Analysis Of Transformative Storytelling As A Catalyst For Belonging, Kennedy Kleinman

Undergraduate Honors Theses

This thesis examines how transformative storytelling functions as a catalyst for belonging within institutional contexts, focusing on Brigham Young University (BYU). While institutions increasingly prioritize belonging through policies and programs, many students continue to experience isolation, loneliness, and belonging uncertainty. This project argues that storytelling addresses this gap by providing students with opportunities to participate in their own belonging and contribute to feelings of belonging for other students. This study analyzes student stories developed in structured workshops and shared at BYU campus StorySLAM events. Stories are evaluated for their use of four rhetorical tactics: counter-narrative, bridge-building between ingroups and outgroups, …

Ifnγ-Induced Antigen Loss In Chimeric Antigen Receptor-T Cell Therapy, Miao Cao, Jasmine Alvarez, Ramkrishna Mitra, Michael Xu, Trevor R. Baybutt, Zhengyang Sun, Oluwatobiloba Taylor, Allison Doermann, Ross E Staudt, Scott A. Waldman, Adam E. Snook

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

INTRODUCTION: FDA-approved chimeric antigen receptor (CAR)-expressing T cell therapies (CARTs) have revolutionized the treatment of blood cancers. Yet none have been successful for "solid" tumors, such as colorectal cancer (CRC), the 2nd leading cause of cancer deaths. Guanylyl cyclase C (GUCY2C) has emerged as a clinical-stage target for CART and bispecific T-cell engager (BiTE) therapies in CRC. IFNγ has been canonically recognized as beneficial for the effector functions of T cells by enhancing antigen processing and HLA presentation and is essential for CART targeting of solid malignancies by inducing adhesion molecule expression for synapse stabilization.

METHODS: Using

RESULTS: We identified …

Cannibalism, Predation, And Refuges Of Juvenile Blue Crabsfrom A 37–Year Experiment, Anson H. Hines, Margaret A. Kramer, Kimberly D. Richie, L. David Smith, Robert Aguilar, Matthew B. Ogburn, Eric G. Johnson, Gregory M. Ruiz

Biological Sciences: Faculty Publications

This 37-y record (1989–2025) of field experiments tested seasonal and annual variation in predation on juvenile blue crabs (Callinectes sapidus) in a representative mesohaline site of Chesapeake Bay, USA, where the species is a dominant epibenthic predator and major fishery. We used replicated sets of individually tethered crabs to provide a relative index of lethal and sublethal predation rates on intermolt individuals as a function of size and habitats. Cannibalism by large adult crabs accounted for>97% of predation of juvenile crabs; predation by fish was not observed; and mortality from physiological stress was rare (< 1%). Sampling by depth showed that juveniles occurred in nearshore shallows, while adults were in deeper water. Cannibalism was also depth-dependent: Rates were high at 75 cm depth; intermediate at 40cm; and lowest at 15 cm shallows, which provided partial refuge. Cannibalism was size-dependent: 30 to 50 mm juveniles experienced high rates of predation; 90 to 110mm preadults had low rates; and >120 mm adults …

Lanthorn, Vol. 60, No. 13, March 16, 2026, Grand Valley State University

Volume 60, August 4, 2025 – current

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

An Exploration Into Network Analyses Of Motor Behavior, Brain-Computer Interface Control, Arousal States, And An Ischemic Lesion Model, Shashank Anand

McKelvey School of Engineering Graduate Student Theses & Dissertations

Network-level modelling of neural function incorporates activity in specific brain regions along with a measure of the interactions between these regions (“connectivity”). Connectivity can be assessed through several means, for example through tractography (structural connectivity) or correlated temporal evolution of neural activity (functional connectivity). These analyses have provided valuable insight into several aspects of brain function, such as top-down control, memory, and navigation. This work focuses on studying neural activity within and between several brain regions across different brain states: namely, during motor actions, sensory perception, brain-computer interface engagement, task-free fluctuations in arousal state, and ischemic injury. High gamma (70-170 …

Seeds Of Change - Building Community And Resilience With Plant Guilds, Roslynn Mccann, Liliane Dionne, Kevin White

All Current Publications

The goals of this Grade 6 living systems/biodiversity curriculum are to highlight Indigenous (First Nations, Métis, and Inuit) contributions to science, technology, and sustainable agriculture, with a focus on relational worldviews, permaculture practices, and respect for Mother Earth. Students will conduct plant experiments, learn Indigenous stories, make corn husk dolls, create a recipe, and enjoy eating their soup creation.

Lifestyle Intervention Therapy Modulates Global Dna Methylation And Adipogenic Gene Expression In Severely Obese Hypogonadal Men, Siresha Bathina, Virginia Fuenmayor Lopez, Mia Prado, Salina Biene Teo, Dennis T Villareal, Rui Chen, Clifford Qualls, Reina Armamento-Villareal

Faculty, Staff and Students Publications

Background/Objectives: Previous studies have suggested that lifestyle intervention (LSI) therapies involving diet and exercise can modulate DNA methylation; however, whether this occurs in severely obese hypogonadal men undergoing weight loss from diet and exercise remains unclear.

Methods: In this study, we investigated the effects of weight loss from diet and exercise on global DNA methylation as well as on the mRNA expression of specific demethylation enzymes, DNMT1, DNMT3A, and DNMT3B—in peripheral blood mononuclear cells (PBMCs) and DNA methylation markers in DNA of severely obese hypogonadal men. This is a secondary analysis of samples of severely obese (body …

Extraction And Application Of Biopolymer (Chitosan) From The Waste Of Iraqi Agricultural Crop (Mushroom), Ruaa A. Salman, Wisam K. Hamdan, Hussain A. Jaber

Engineering and Technology Journal

The current work extracted the chitosan from the waste of mushroom crops for the first time in Iraq. The chemical process was adopted for demineralization with 2M HCl, deproteinization with 2M NaOH, and decolorization. Also, the refluxing process with 60% NaOH for chitin was applied. The XRD result shows two peaks around 2θ =10° and 20°, indicating the ordered crystalline structure of chitosan. The FT-IR spectrum showed specific bands of chitosan at 3327.97, 2918.71, and 1645.95 cm^-1. Also, the FE-SEM results show a smooth, dense, and non-porous surface. The viability results on white blood cells (WBCs) show the …

Seasonal Dynamics And Trends Of Environmental Conditions In Lake Louise, Georgia, Daniel Kwawuvi, James A. Nienow

Georgia Journal of Science

Lakes are important aquatic ecosystems that are extensively influenced by seasonal variations. In this study we investigate the seasonal dynamics and trends of three environmental variables, water temperature, conductivity and dissolved oxygen (DO), in Lake Louise, a sinkhole lake located in southern Georgia. These variables were measured in-situ along a depth profile from January 27, 2024 to January 17, 2025. We also accessed archived data from field campaigns in 2003, 2004, and 2017 in order to test whether a recent increase in the number of hurricanes impacting the region, five since August, 2017, may have significantly altered the seasonal dynamics …

Sheikh Ḥilu: A Crusader Structure And Additional Remains From The Iron Age And Late Ottoman Period, Yoav Arbel, ‘Abed A-Salam Sa‘Id

Qadum: Journal of Excavation Reports from Israel

Excavations at the site of Sheikh Ḥilu in Ḥadera revealed the remains of a possible manor house or farm dating from the Crusader period. The partially exposed two-phase complex is a rare example of a settlement from this period in the Sharon plain. Careful planning and relatively high construction quality attest to its significance; however, apart from its solid architecture, there is no evidence of fortification. The site underwent a non-violent abandonment at the end of the Crusader period, after which it was temporarily settled by squatters. In the late Ottoman period and the early twentieth century, this was the …

"This Is Not A Scam!": Assessment Of An Awareness Raising Program Tackling Older Adults' Scam Victimization In A Multi-Method Study, Katalin Parti, Pamela Teaster, Susanna Rinehart, Charles Dye

Qualitative Criminology (QC)

"Interactive theatre has long been used to educate and empower communities and prevent crime across all age groups. Although older populations are disproportionately victimized through fraudulent online schemes, effective educational interventions, like interactive theatre, have not been utilized to increase crime awareness. This paper describes an explorational research project, analyzing the results of a theatre-based fraud awareness program aimed towards educating victims and their communities about scams targeting older people. The study employs a mixed-method research design to examine program impact. In applying multifaceted tools of data collection, such as survey, participant observation, and follow-up interviews, the research team identified …

The Sequence Of The Creation Of The Universe And The Rest Between Jewish Thought And The Interpreters Of The Imamiyyah (Al-Tibyan And Al-Mizan As A Model), Haider Abbas Kadhim, Khalid Ahmed Hussein

Alustath Journal for Human and Social Sciences

The Torah talks about the creation of the universe in the Book of Genesis, as this book tells the sequence of this creation, and that it was completed in six earthly days consisting of morning and evening, so according to the order of the Torah, the earth, light, darkness, and water were created, then the sky was created when he placed a skin between waters and waters, then the waters gathered under the skin that was called the sky, so the land was formed and the grass and herbs grew, then the sun, moon, and stars were created above the …

The Impact Of Imam Al-Ridha’S Philosophical Dialogues On Abbasid Literature, Musaab Abdulrahman M Al Mashhadani, Khalil Brouwini, Hadi Nazari

Alustath Journal for Human and Social Sciences

Imam Ali ibn Musa al-Ridha (peace be upon him) is considered one of the most influential figures in the history of Islamic thought. Through his profound philosophical dialogues, he left a significant mark on Abbasid-era intellectual and literary traditions. These dialogues encompassed discussions with philosophers and scholars from various cultures and religions of the Abbasid period, aiming to bridge reason and revelation while clarifying numerous philosophical and theological issues. Imam al-Ridha’s philosophical discussions addressed topics such as monotheism, divine justice, rationality, ethics, and guidance, contributing to the spread of rational thought within Abbasid society. Abbasid literature was profoundly influenced by …

Characterisation Of Pouch Secretions From Breeding Tasmanian Devils, Manujaya W. Jayamanna Mohottige, Emma Peel, Angéla Juhász, Mitchell G. Nye-Wood, Katherine Belov, Michelle L. Colgrave, Carolyn J. Hogg

Research outputs 2022 to 2026

Tasmanian devils (Sarcophilus harrisii), like all marsupials, give birth to altricial young. Here we employ proteomic analysis to identify components of devil pouch secretions that may contribute to offspring survival and development. Proteins were extracted from five samples and analysed by liquid chromatography-tandem mass spectrometry. Peptide-level evidence revealed proteins involved in a diverse set of immune pathways, including those mediating iron-ion transport, defence responses to bacteria, innate immune responses, and antigen processing. A core set of 200 proteins was identified across at least three samples, 63 of which were associated with antimicrobial or immunoregulatory functions. These included immunoglobulins, components of …

Medical Detection Dogs: A Visual Exploration Of Canine Olfactory Anatomy & Volatile Organic Compounds As Applied To Non-Invasive Biomedical Detection, Kirsten Santiago

Theses

Medical detection dogs provide a non-invasive early method of disease and medical alert detection that is underrepresented in the medical visualization sector. The domesticated dog, or Canis familiaris, is known for its loving nature and has become an important member of many households, but they are also incredibly intelligent with a capacity for specialized training. Dogs have a specialized olfactory system, allowing them to detect scents with high acuity (Guest & Otto, 20). Volatile organic compounds or VOCs are molecular substances associated with metabolic processes that are often a result or byproduct of certain diseases and can be influenced by …

The Influence Of Presurgical Mandibular Incisor Inclination On The Stability Of Surgical Class Iii Patients: A Systematic Review, Houda Ousli, Youssef Oualalou, Fatima Zaoui, Asmae Bahoum

International Arab Journal of Dentistry

Objective: This study aims to assess the impact of presurgical mandibular incisor inclination on the stability of surgical class III patients.

Methods: An electronic search was conducted on PubMed, Scopus, Web of Science, EBSCO, and the Cochrane Library from 2014 to February 2025, initially identifying 351 publications relevant to our review.

Results: Four retrospective studies were included in this review, with the risk of bias ranging from low to serious. A preoperative retroinclined incisal axis leads to an increased post-surgical overjet and inadequate interincisal contact, indicating that retroclined mandibular incisors may affect skeletal stability. However, Overcorrection of mandibular incisor inclination …

Pictures Of The Interactive Model Of The Saying Of The Original Model, A Reading Of The Qur’Anic Representations, Tahrir Qasim Saadoun, Nima Dahsh Farhan

Alustath Journal for Human and Social Sciences

The importance of this research comes in accordance with the research in cognitive psychology and cognitive linguistics related to the renewed concept, along with the work of Roche, which presented anthropological and mystical concepts that investigate the mystical constants that have a universal form. The concept of the saying in the theory of archetypes depends on the concept of mental image and referential connotation, to highlight the relationship between perception and language within the framework of experimental realism, which is the basic starting point in cognitive theory. The problem of the research appears from the possibility of considering the associative …

Engineering 50 Years From Today: A Purdue Engineering Community Perspective, Arvind Raman

Purdue University Press Books

Since opening its doors in 1874, Purdue University’s College of Engineering and its graduates have been at the forefront of technological breakthroughs and are now poised to lead the next generation of engineers in the United States and around the globe. Featuring more than twenty-five essays from former Boilermakers, Engineering 50 Years From Today both celebrates the program’s 150th anniversary and looks ahead, exploring what the field of engineering might look like half a century from now. Leading luminaries from Purdue’s engineering community, including prominent university professors as well as innovators working in the private sector, reveal how technologies related …

Embodied Transcendence: Psychedelics And The Evolution Of Moral Abstraction, Emanuel Jas

Journal of Conscious Evolution

This paper explores the role of psychedelics in the context of evolutionary brain development and the conceptual capacity for moral realism. Drawing on theories from evolutionary anthropology, neuroscience, and moral philosophy, the first part provides a brief overview of human evolution and brain expansion. From here, recent empirical data from the neurosciences is assessed on the effect psychedelics have on the brain, along with speculations on the role of psychedelics in our hominoid evolutionary history—specifically, the capacity for phenomenologically rich, conscious, subjective experiences that are incredibly vivid and real. This imaginative capacity for transcendence and disembodiment could enable the realization …

Targeted Therapy In Hepatobiliary Pancreatic Cancer (Hpc): Advantages And Advancements Of Antibody Drug Conjugates, A Type Of Chemo-Biologic Hybrid Drugs, Tushar Deb Nath, Attrayo Mukherjee, Subhash Chauhan, Debasish Bandyopadhyay

School of Integrative Biological & Chemical Sciences Faculty Publications

Currently, there are very few efficient treatment options for hepatobiliary pancreatic cancer (HPC), which comprises pancreatic ductal adenocarcinoma (PDAC), biliary tract cancer (BTC), and hepatocellular carcinoma (HCC). The HPC tumors are the most lethal malignant tumors in the world. Traditional chemotherapy offers little survival benefit and is associated with notable systemic toxicity, which has made antibody–drug conjugates (ADCs) a hopeful treatment option. Strong cytotoxic drugs combine with monoclonal antibodies to attack tumor-associated antigens. This review discusses the benefits and current developments of Antibody–Drug Conjugates (ADCs) in treating HPC. It also covers their mechanisms of action, ongoing clinical trials, and the …

Vascular Contribution To Cognitive Impairment And Dementia (Vcid): Proceedings Of 2025 Workshop Of The Jackson Laboratory., Mehwish Anwer, Tetiana Poliakova, Ricardo D'Oliveira Albanus, Mohammad Iqbal H Bhuiyan, Adam M Brickman, Soumilee Chaudhuri, Leah Cuddy, Maxwell Eisenbaum, Kate Foley, Douglas B Gould, Catherine Hall, Costantino Iadecola, Olivia J Marola, Christopher M Norris, Alaina M Reagan, Julie Schneider, Donna Wilcock, Isabella Xu, Andrew Yang, Gareth R Howell, Cheryl L Wellington

Faculty Research 2026

The first Vascular Contributions to Cognitive Impairment and Dementia (VCID) Workshop, held on May12-16, 2025 at The Jackson Laboratory, provided scientific content and career development training in the latest developments in VCID and Alzheimer's Disease (AD) and related dementia (ADRD). The Workshop aimed to foster interdisciplinary collaborations and empower the next generation of diverse scientists to advance ADRD research from mechanism to intervention. The meeting placed a strong emphasis on neurovascular pathology, its central role in ADRD pathogenesis, its modulation by both central and peripheral factors, and the critical need to dissect the mechanistic basis of VCID through experimental models. …

Vascular Contribution To Cognitive Impairment And Dementia (Vcid): Proceedings Of 2025 Workshop Of The Jackson Laboratory., Mehwish Anwer, Tetiana Poliakova, Ricardo D'Oliveira Albanus, Mohammad Iqbal H Bhuiyan, Adam M Brickman, Soumilee Chaudhuri, Leah Cuddy, Maxwell Eisenbaum, Kate Foley, Douglas B Gould, Catherine Hall, Costantino Iadecola, Olivia J Marola, Christopher M Norris, Alaina M Reagan, Julie Schneider, Donna Wilcock, Isabella Xu, Andrew Yang, Gareth R Howell, Cheryl L Wellington

Faculty Research 2026

The first Vascular Contributions to Cognitive Impairment and Dementia (VCID) Workshop, held on May12-16, 2025 at The Jackson Laboratory, provided scientific content and career development training in the latest developments in VCID and Alzheimer's Disease (AD) and related dementia (ADRD). The Workshop aimed to foster interdisciplinary collaborations and empower the next generation of diverse scientists to advance ADRD research from mechanism to intervention. The meeting placed a strong emphasis on neurovascular pathology, its central role in ADRD pathogenesis, its modulation by both central and peripheral factors, and the critical need to dissect the mechanistic basis of VCID through experimental models. …

Cell Type-Specific Enhancers Regulate Il-22 Expression In Innate And Adaptive Type 3 Lymphoid Cells, Ankita Saini, Leone S Hopkins, Vanida A Serna, Matthew V D Mccullen, Nicholas G Selner, Bishan Bhattarai, José L Fachi, Rebecca A Glynn, Katharina E Hayer, Craig H Bassing, Marco Colonna, Eugene M Oltz

2020-Current year OA Pubs

IL-22, a signature cytokine for type 3 lymphoid cells, including T helper 17/22 (Th17/22) and type 3 innate lymphoid cells (ILC3), mediates epithelial homeostasis and protective pathogen responses in barrier tissues. Upon dysregulation, IL-22 can drive chronic inflammatory diseases, yet little is known about transcriptional elements modulating its expression. Here, we identify two enhancers, E22-1 and E22-2, with distinct capacities for regulating Il22 expression in type 3 lymphoid cells. Both enhancers are necessary for protection from Citrobacter rodentium infection and for the onset of IL-22-mediated psoriasis. E22-2 is specifically required for IL-22 expression in ILC3s, while E22-1 functions in both …

Flight Of The Gods: Charting The Terra Incognita Of Belief Through Dragon Literature, Alanna Hess

Undergraduate Honors Theses

“Flight of the Gods” is a fantasy short story that portrays a religious relationship between humans and dragons to explore themes of religious questioning. In doing so, “Flight of the Gods” unites with modern dragon literature by adapting the dragon motif to address real-world issues. Drawing from research on falcons and falconry, the dragons in this short story exhibit a complex relationship with their human counterparts that emphasizes themes of religious doubt and the complexity of belief. The thesis begins with a critical introduction discussing these topics and then presents the short story.