Digital Commons Network^™

"From 'I Will' To 'I Can:' The Political And Pedagogical Playfulness Of Tyson E. Lewis" In T.E. Lewis, Educational Potentialities: Collected Talks On Revolutionary Education, Aesthetics, And Organization, Derek R. Ford

Education Studies Faculty publications

Having the chance to introduce the thinking (and talking) of Tyson E. Lewis to a new audience of revolutionary activists and organizers is exciting and intimidating. It’s exciting because this collection of talks, which cover much of his ex- tensive research interests and span more than a decade, is filled with raw materials out of which communists can produce politically timely and incisive educational practices, theories, and experiments. It’s intimidating for the same reasons. Instead of writing an introduction, then, I’m going to write three. (beginning paragraph)

Alfred Russel Wallace Notes 25. Wallace And The 'Physical Environment'., Charles H. Smith

Faculty/Staff Personal Papers

Alfred Russel Wallace’s natural selection essay of 1858 has been held to frame a greater role for the physical environment in forcing selection regimes than we find in Darwin’s writings, but here that verdict is challenged by a re-examination of both the essay itself, and period usage of the term ‘physical.’

Independent - Apr. 1, 2023, Monty Stites

The Independent (1988-present)

No abstract provided.

Using Object Detection To Navigate A Game Playfield, Peter Kearnan Hyde-Smith

Master's Theses (2009 -)

Perhaps the crown jewel of AI is the self-navigating agent. To take many sources of data as input and use it to traverse complex and varied areas while mitigating risk and damage to the vehicle that is being controlled, visual object detection is a key part of the overall suite of this technology. While much efforts are being put towards real-world applications, for example self-driving cars, healthcare related issues and automated manufacturing, we apply object detection in a different way; the automation of movement across a video game play field. We take the TensorFlow Object Detection API and use it …

The Influence Of The Digitization Method On The Assessment Of Accuracy And Reliability Of Implant Placements, Ajitesh Singh

Master's Theses (2009 -)

Purpose: Studies investigating the accuracy of implant placement are utilizing different methods to digitize the post-operative implant position to compare it with the planned reference position. This study aimed to compare the influence on radiographic and digital methods in the accuracy of static computer-assisted and free hand implant placement.Methods: In total, n=40 implants were placed either fully guided (n=20) or free-handed (n=20) in standardized mandible replicas. A static surgical guide was planned for the fully guided surgery group (FG) for an implant at the lower right first molar site and 3D printed. In the free-hand group (FH) the implant surgery …

Mechanisms Of The Age-Related Power Reduction In The Knee Extensor Muscles Of Men And Women, David Wrucke

Master's Theses (2009 -)

The mechanisms for the loss in limb muscle power output in old (60-79 years) and very old adults (≥80 years) and whether these mechanisms differ between older men and women are not well-understood. The aims of the thesis are to 1) compare peak power output of the knee extensor muscles between young, old, and very old adults and 2) determine the physiological mechanisms for the age-related loss of power in men compared with women. 31 young (22.9±3.0 years, 16 men), 83 old (70.4±4.9 years, 44 men), and 16 very old adults (85.8±4.2 years, 7 men) performed maximal isokinetic contractions at …

Effect Of Storage Condition On Penetration Threshold Of Porcine Skin Tissue, Jared Michael Koser

Master's Theses (2009 -)

Buried blast explosions create small projectiles which can become lodged in the tissue of personnel as far away as hundreds of meters. Without appropriate treatment, these lodged projectiles can become a source of infection and prolonged injury to soldiers in modern combat. Human cadavers can be used as surrogates for living humans for ballistic penetration testing, but human cadavers are frozen during transport and storage. The process of freezing and thawing the tissue before testing may change the biomechanical properties of the tissue. The goal of the current study was to investigate the effect of tissue storage on penetration threshold …

Immediate Postoperative Dimensional Changes Following Implant Placement, Juan Felipe Valencia Rincon

Master's Theses (2009 -)

Objective: Hard tissue outcomes after implant placement have been well documented. However, there is scarce evidence on immediate soft tissue and patient-centered outcomes. The aim of this prospective study is to quantify post-implant placement edema and to correlate it with oral health-related quality of life. Methods: Patients undergoing a standardized two-stage implant placement at a single tooth-bound site were recruited (n=26; 54.13.3 years, 14 males). Soft tissue edema was recorded by using intraoral scans immediately pre- (PS) and post-operatively (IP), at 2 (2D), 7 (7D) and 14 days (14D) and 2 months (2M). After scan registration, ridge width, maximum height, …

The Global Health Architecture: Governance And International Institutions To Advance Population Health Worldwide, Lawrence O. Gostin, Eric A. Friedman, Alexandra Finch

Georgetown Law Faculty Publications and Other Works

Policy Points Global health institutions and instruments should be reformed to fully incorporate the principles of good health governance: the right to health, equity, inclusive participation, transparency, accountability, and global solidarity. New legal instruments, like International Health Regulations amendments and the pandemic treaty, should be grounded in these principles of sound governance. Equity should be embedded into the prevention of, preparedness for, response to, and recovery from catastrophic health threats, within and across nations and sectors. This includes the extant model of charitable contributions for access to medical resources giving way to a new model that empowers low- and middle-income …

Rage Inhibitors In Neurodegenerative Diseases, V. Prakash Reddy, Puspa Aryal, Pallavi Soni

Chemistry Faculty Research & Creative Works

Nonenzymatic Reactions of Reducing Sugars with Primary Amino Groups of Amino Acids, Proteins, and Nucleic Acids, Followed by Oxidative Degradations Would Lead to the Formation of Advanced Glycation Endproducts (AGEs). the AGEs Exert Multifactorial Effects on Cell Damage Leading to the Onset of Neurological Disorders. the Interaction of AGEs with the Receptors for Advanced Glycation Endproducts (RAGE) Contribute to the Activation of Intracellular Signaling and the Expression of the Pro-Inflammatory Transcription Factors and Various Inflammatory Cytokines. This Inflammatory Signaling Cascade is Associated with Various Neurological Diseases, Including Alzheimer's Disease (AD), Secondary Effects of Traumatic Brain Injury (TBI), Amyotrophic Lateral Sclerosis …

Unsupervised Progressive And Continual Learning Of Disentangled Representations, Zhiyuan Li

Theses

Unsupervised representation learning is an important task in machine learning that identifies and models underlying explanatory factors hidden in the observed data. In recent years, unsupervised representation learning has been attracting increasing attention for its abilities to improve interpretability, extract useful features without expert annotations, and enhance downstream tasks, which has been successful in many machine learning topics, such as Computer Vision, Natural Language Processing, and Anomaly Detection. Unsupervised representation learning has many desirable abilities, including disentangling generative factors, generalization between different domains, and incremental knowledge accumulation. However, existing works had faced two critical challenges. First, the unsupervised representation learning …

Ensuring Food Security, Converting Urban Industrial Buildings For Indoor Agriculture: The Call For Urban Indoor Agriculture, Christopher Quinn Whittaker

Theses

Outdated food production models result in the continued disconnect between communities and vital nutrition. Poverty and a lack of food awareness perpetuate the effects of food insecurity within communities. These effects are most evident in urban areas where fresh produce is out of reach for large swaths of the population. Connecting communities back to the food they eat will benefit cities and residents economically, socially, and environmentally. Farming with the community in the community will empower a broad urban population. Urban areas pose several challenges to food production, such as a lack of open space and a high volume of …

Consensus-Based Evaluation Of Outcome Measures In Pediatric Stroke Care: A Toolkit, Samantha J Feldman, Lauren A Beslow, Ryan J Felling, Laura A Malone, Michaela Waak, Stuart Fraser, Nihal Bakeer, Jo Ellen M Lee, Victoria Sherman, Melissa M Howard, Beth Anne Cavanaugh, Robyn Westmacott, Lori C Jordan

Faculty, Staff and Student Publications

Following a pediatric stroke, outcome measures selected for monitoring functional recovery and development vary widely. We sought to develop a toolkit of outcome measures that are currently available to clinicians, possess strong psychometric properties, and are feasible for use within clinical settings. A multidisciplinary group of clinicians and scientists from the International Pediatric Stroke Organization comprehensively reviewed the quality of measures in multiple domains described in pediatric stroke populations including global performance, motor and cognitive function, language, quality of life, and behavior and adaptive functioning. The quality of each measure was evaluated using guidelines focused on responsiveness and sensitivity, reliability, …

Model-Constrained Reconstruction Accelerated With Fourier-Based Undersampling For Hyperpolarized [1-13c] Pyruvate Imaging, Zhan Xu, Keith A Michel, Christopher M Walker, Collin J Harlan, Gary V Martinez, Jeremy W Gordon, Hsin-Yu Chen, Daniel B Vigneron, James A Bankson

Faculty, Staff and Student Publications

PURPOSE: Model-constrained reconstruction with Fourier-based undersampling (MoReFUn) is introduced to accelerate the acquisition of dynamic MRI using hyperpolarized [1-

METHODS: The MoReFUn method resolves spatial aliasing using constraints introduced by a pharmacokinetic model that describes the signal evolution of both pyruvate and lactate. Acceleration was evaluated on three single-channel data sets: a numerical digital phantom that is used to validate the accuracy of reconstruction and model parameter restoration under various SNR and undersampling ratios, prospectively and retrospectively sampled data of an in vitro dynamic multispectral phantom, and retrospectively undersampled imaging data from a prostate cancer patient to test the fidelity …

De Novo Mutations Disturb Early Brain Development More Frequently Than Common Variants In Schizophrenia, Toshiyuki Itai, Peilin Jia, Yulin Dai, Jingchun Chen, Xiangning Chen, Zhongming Zhao

Faculty, Staff and Student Publications

Investigating functional, temporal, and cell-type expression features of mutations is important for understanding a complex disease. Here, we collected and analyzed common variants and de novo mutations (DNMs) in schizophrenia (SCZ). We collected 2,636 missense and loss-of-function (LoF) DNMs in 2,263 genes across 3,477 SCZ patients (SCZ-DNMs). We curated three gene lists: (a) SCZ-neuroGenes (159 genes), which are intolerant to LoF and missense DNMs and are neurologically important, (b) SCZ-moduleGenes (52 genes), which were derived from network analyses of SCZ-DNMs, and (c) SCZ-commonGenes (120 genes) from a recent GWAS as reference. To compare temporal gene expression, we used the BrainSpan …

Hyperphosphorylated Tau In Mesial Temporal Lobe Epilepsy: A Neuropathological And Cognitive Study, Eliana C B Toscano, Érica L M Vieira, Lea T Grinberg, Natalia P Rocha, Joseane A S Brant, Regina S Paradela, Alexandre V Giannetti, Claudia K Suemoto, Renata E P Leite, Ricardo Nitrini, Milene A Rachid, Antonio L Teixeira

Faculty, Staff and Student Publications

Temporal lobe epilepsy (TLE) often courses with cognitive deficits, but its underlying neuronal basis remains unclear. Confluent data suggest that epilepsy share pathophysiological mechanisms with neurodegenerative diseases. However, as most studies analyze subjects 60 years old and older, it is challenging to rule out that neurodegenerative changes arise from age-related mechanisms rather than epilepsy in these individuals. To fill this gap, we conducted a neuropathological investigation of the hippocampal formation of 22 adults with mesial TLE and 20 age- and sex-matched controls (both younger than 60 years). Moreover, we interrogated the relationship between these neuropathological metrics and cognitive performance. Hippocampal …

Myosin Light-Chain 4 Gene-Transfer Attenuates Atrial Fibrosis While Correcting Autophagic Flux Dysregulation, Yuan Zhong, Kai Tang, Stanley Nattel, Ming Zhai, Shiyu Gong, Qing Yu, Yanxi Zeng, Guangxi E, Nuerbiyemu Maimaitiaili, Jun Wang, Yawei Xu, Wenhui Peng, Hailing Li

Faculty, Staff and Student Publications

OBJECTIVES: To determine the role of MYL4 regulation of lysosomal function and its disturbance in fibrotic atrial cardiomyopathy.

BACKGROUND: We have previously demonstrated that the atrial-specific essential light chain protein MYL4 is required for atrial contractile, electrical, and structural integrity. MYL4 mutation/dysfunction leads to atrial fibrosis, standstill, and dysrhythmia. However, the underlying pathogenic mechanisms remain unclear.

METHODS AND RESULTS: Rats subjected to knock-in of a pathogenic MYL4 mutant (p.E11K) developed fibrotic atrial cardiomyopathy. Proteome analysis and single-cell RNA sequencing indicate enrichment of autophagy pathways in mutant-MYL4 atrial dysfunction. Immunofluorescence and electron microscopy revealed undegraded autophagic vesicles accumulated in MYL4

CONCLUSIONS: …

The Glycoprotein Cd147 Defines Mirna-Enriched Extracellular Vesicles That Derive From Cancer Cells, Song Yi Ko, Wonjae Lee, Melanie Weigert, Eric Jonasch, Ernst Lengyel, Honami Naora

Faculty, Staff and Student Publications

Extracellular vesicles (EVs) are ideal for liquid biopsy, but distinguishing cancer cell‐derived EVs and subpopulations of biomarker‐containing EVs in body fluids has been challenging. Here, we identified that the glycoproteins CD147 and CD98 define subpopulations of EVs that are distinct from classical tetraspanin+ EVs in their biogenesis. Notably, we identified that CD147+ EVs have substantially higher microRNA (miRNA) content than tetraspanin+ EVs and are selectively enriched in miRNA through the interaction of CD147 with heterogeneous nuclear ribonucleoprotein A2/B1. Studies using mouse xenograft models showed that CD147+ EVs predominantly derive from cancer cells, whereas the majority of tetraspanin+ EVs are not …

Emerging Role Of Tak1 In The Regulation Of Skeletal Muscle Mass, Anirban Roy, Vihang A Narkar, Ashok Kumar

Faculty, Staff and Student Publications

Maintenance of skeletal muscle mass and strength throughout life is crucial for heathy living and longevity. Several signaling pathways have been implicated in the regulation of skeletal muscle mass in adults. TGF-β-activated kinase 1 (TAK1) is a key protein, which coordinates the activation of multiple signaling pathways. Recently, it was discovered that TAK1 is essential for the maintenance of skeletal muscle mass and myofiber hypertrophy following mechanical overload. Forced activation of TAK1 in skeletal muscle causes hypertrophy and attenuates denervation-induced muscle atrophy. TAK1-mediated signaling in skeletal muscle promotes protein synthesis, redox homeostasis, mitochondrial health, and integrity of neuromuscular junctions. In …

Rural Bashing, Kaceylee Klein, Lisa R. Pruitt

University of Richmond Law Review

Anti-rural sentiment is expressed in the United States in three major threads. The first is a narrative about the political structure of our representative democracy—an assertion that rural people are over-represented thanks to the structural features of the U.S. Senate and the Electoral College. Because rural residents are less than a fifth of the U.S. population, complaints about this situation are often framed as “minority rule.”

The second thread is related to the first: rural people and their communities get more than their fair share from federal government coffers. The argument, often expressed in terms of “subsidies,” is that rural …

With A Wink And A Nod: How Politicians, Regulators, And Corrupt Coal Companies Exploited Appalachia, Patrick C. Mcginley

University of Richmond Law Review

Environmental regulators treated America’s leading coal companies like Wall Street’s mismanaged banks leading to the “Great Recession”—big coal companies that produced millions of tons of coal were simply too big to fail. With a wink and a nod, federal and state regulators ignored a core provision of federal law that was intended to prevent coal companies from continuing their past practices of plundering Appalachia’s mineral wealth while ravaging her environment.

This Article examines how the coal industry successfully evaded compliance with that law. The consequences of this evasion include mass bankruptcies, thousands of acres of mined land laying unclaimed, …

Rural America As A Commons, Ann M. Eisenberg

University of Richmond Law Review

With many ready to dismiss non-urban life as a relic of history, rural America’s place in the future is in question. The rural role in the American past is understandably more apparent. As the story of urbanization goes in the United States and elsewhere, the majority of the population used to live in rural places, including small towns and sparsely populated counties. A substantial proportion of those people worked in agriculture, manufacturing, or extractive industries. But trends associated with modernity—mechanization, automation, globalization, and environmental conservation, for instance—have reduced the perceived need for a rural workforce. Roughly since the industrial revolution …

The World View Of The Believers Of “Strive To Benefit Humanity” (홍익인간): Vertical And Horizontal Connectivity, Yeomin Yoon

KAUPA Letters

No abstract provided.

Native American Intellectual Property Protection: Altering Federal Ip Law And The Indian Arts And Crafts Act To Aid Tribal Economic Development, Trey V. Perez

American Indian Law Journal

Native Americans tribes remain subject to an epidemic of poverty. Although tribal gaming has provided relief and a method of economic development for some groups, other tribes are unable to employ gaming to bring in revenue and grow out of poverty. One method to assist tribes that cannot use tribal gaming could be amending federal intellectual property law to better suit tribes needs and allowing them to better exploit the billion-dollar Native American arts and crafts industry.

Moreover, tribes are able to determine which artists qualify as “Indian” under the Indian Arts and Crafts Act, which leaves individual artists subject …

Drinking Water Contaminants: Bacteria, Bruce I. Dvorak, Becky O. Schuerman

Department of Civil and Environmental Engineering: Faculty Publications

Testing drinking water for fecal bacteria or Escherichia coli (E. coli) is commonly used as an indicator of the presence of pathogenic microorganisms. The presence of pathogenic (disease-causing) microorganisms is a concern when considering the safety of drinking water. Pathogenic microorganisms can cause flu-like systems, intestinal infections, dysentery, hepatitis, typhoid fever, cholera, and other illnesses.

The Possible Role For Basigin Receptor Function In The Induction Of Matrix Metalloproteinase Expression In Human Endometrial Stromal Cells, Amy Abel

All NMU Master's Theses

10-15% of couples worldwide are affected by infertility. The leading cause of infertility is implantation failure. Molecular communication in precise time and space between an implanting embryo and a receptive uterus is essential for successful implantation. Basigin has been shown to have vital functions within the implantation process. Basigin is best known for inducing the expression of matrix metalloproteinases. Basigin has been shown to induce MMP expression in vitro in human endometrial stromal cell lines (HESC). Understanding how basigin induces matrix metalloproteinases within normal cellular conditions will help researchers understand how these signaling cascades flow in the framework of implantation. …

The Status Of Invasive Dusky Slug (Arion) Species In The Upper Great Lakes: A Molecular Approach, Olivia W. Hall

All NMU Master's Theses

I update the distribution of two cryptic slug species, Arion fuscus and Arion subfuscus, in the Upper Great Lakes of the United States using molecular identification methods. Arion fuscus has not previously been reported in the literature in this region, and Arion subfuscus has previously been reported as abundant. However, all previous distribution studies were determined using visual identification tools, which can result in misidentification between cryptic species. To molecularly re-examine these distribution maps, I used a mitochondrial ribosomal subunit 16S PCR amplification and subsequent SSpI and MfeI restriction enzyme digest to identify slug specimens. I collected slugs in …

Highly Pathogenic Avian Influenza A(H5n1) Virus Outbreak In New England Seals, United States, Wendy Puryear, Kaitlin Sawatzki, Nichola Hill, Alexa Foss, Jonathon J. Stone, Lynda Doughty, Dominique Walk, Katie Gilbert, Maureen Murray, Elena Cox, Priya Patel, Zak Mertz, Stephanie Ellis, Jennifer Taylor, Deborah Fauquier, Ainsley Smith, Robert A. Digiovanni, Adriana Van De Guchte, Ana Silvia Gonzalez-Reiche, Zain Khalil, Harm Van Bakel, Mia K. Torchetti, Kristina Lantz, Julianna B. Lenoch, Jonathan Runstadler

United States Department of Agriculture Wildlife Services: Staff Publications

We report the spillover of highly pathogenic avian influenza A(H5N1) into marine mammals in the northeastern United States, coincident with H5N1 in sympatric wild birds. Our data indicate monitoring both wild coastal birds and marine mammals will be critical to determine pandemic potential of influenza A viruses.

The Quest To End Human Trafficking: An Educational And Practical Guide For Everyone Who Wants To Help Break The Bonds And Assist Survivors, Dennis W. Mccarty

Emergency Preparedness, Homeland Security, and Cybersecurity Faculty Scholarship

People often assume that only legislators and law enforcement personnel can take meaningful steps to fight human trafficking, one of the most lucrative transnational crimes in the world. This inquiry sought to assess the validity of that belief. The study was informed by the author’s experience as a college instructor of human trafficking and the inspiration he drew from the range and quality of his students’ projects.

The methodology included examining the strategies that governmental and non-governmental organizations are using to fight trafficking and assist survivors. It also considered the work of individual activists and service providers such as social …

The Physician In The Execution Chamber: No Such Thing As The Normal Pain Of Dying, Joel Zivot

California Western International Law Journal

No abstract provided.