Digital Commons Network^™

O Silêncio Da Mulher Carioca Oitocentista E Sua Representação No Romance Naturalista Lar De Pardal Mallet, Jessyca Kimberly De Oliveira Zanetti

Theses and Dissertations

The 19th century represents the arrival of the Portuguese royal family in Brazil and, with it, significant changes in society and the local population. A formerly reclusive member of society begins to take shape not only in public life but also within the literature: the Brazilian woman. Despite her changing social role, prevailing hygienist and medical theories of the time pointed to the lack of vocation of the nineteenth-century woman for rational matters; which in naturalism implies that these pseudo-scientific theories would be the base to dissect and explain the social pathologies of Rio de Janeiro, Brazil, and society at …

Il-15 Enhances Hiv-1 Infection By Promoting Survival And Proliferation Of Ccr5+Cd4+ T Cells, Yuhao Li, Hongbo Gao, Kolin M. Clark, Liang Shan

2020-Current year OA Pubs

HIV-1 usually utilizes CCR5 as its coreceptor and rarely switches to a CXCR4-tropic virus until the late stage of infection. CCR5+CD4+ T cells are the major virus-producing cells in viremic individuals as well as SIV-infected nonhuman primates. The differentiation of CCR5+CD4+ T cells is associated with the availability of IL-15, which increases during acute HIV-1 infection. Here, we report that CCR5 was expressed by CD4+ T cells exhibiting effector or effector memory phenotypes with high expression levels of the IL-2/IL-15 receptor common β and γ chains. IL-15, but not IL-7, improved the survival of CCR5+CD4+ T cells, drove their expansion, …

Utilizing Isothermal Titration Calorimetry To Measure Β-Galactosidase Activity In Dairy Products, Tyler Ronald Jarrard

Theses and Dissertations

The dairy industry uses enzymes to make cheese, alter product flavor, and eliminate lactose. The activities of these enzymes have been measured in clear buffered solutions, but because of the limitations of spectrophotometric methods, enzyme activities have not been measured in opaque or colored dairy products where they are used. Isothermal titration calorimetry (ITC) can be used to determine reaction kinetics in opaque and colored solutions by measuring the heat rate from enzyme-catalyzed reactions as a function of time. This study used ITC to measure β-galactosidase activity in opaque solutions of milk, sweet whey, sweet whey permeate, acid whey, and …

Mmu: 04/10/23–04/16/23, Student Bar Association

Monday Morning Update

This Week @ NDLS

Mass Times

Commons Daily Menu

General Announcements

1L of the Week: Morgan Rubino

2Ls Taking Ls: Lizzy Forzley

Ask a 3L: Emma Hildebrand

Jackie's Corner

Mapping The Metabolic Reprogramming Induced By Sodium-Glucose Cotransporter 2 Inhibition, Aviram Kogot-Levin, Yael Riahi, Ifat Abramovich, Ofri Mosenzon, Bella Agranovich, Liat Kadosh, Rachel Ben-Haroush Schyr, Doron Kleiman, Liad Hinden, Erol Cerasi, Danny Ben-Zvi, Ernesto Bernal-Mizrachi, Joseph Tam, Eyal Gottlieb, Gil Leibowitz

Faculty, Staff and Student Publications

Diabetes is associated with increased risk for kidney disease, heart failure, and mortality. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) prevent these adverse outcomes; however, the mechanisms involved are not clear. We generated a roadmap of the metabolic alterations that occur in different organs in diabetes and in response to SGLT2i. In vivo metabolic labeling with 13C-glucose in normoglycemic and diabetic mice treated with or without dapagliflozin, followed by metabolomics and metabolic flux analyses, showed that, in diabetes, glycolysis and glucose oxidation are impaired in the kidney, liver, and heart. Treatment with dapagliflozin failed to rescue glycolysis. SGLT2 inhibition increased glucose oxidation …

Consciousness, Evolution, And The Self-Organizing Brain, Karen Seymour

Journal of Conscious Evolution

While evolution is guided by natural selection, it is internally driven by self-organizing processes. The brain encompasses these complementary forces and dynamics of evolution in both its structure and dynamics by embodying a historical record of the factors that have shaped it throughout its evolutionary past, as well as by being shaped by selective parameters in real time. Self-organization is evident in not only the brain’s structure and form, but also in the processes that support consciousness. From the convergence of complex structure and the novelty-generating dynamics of chaos that both characterize the brain arises the experience of explicit consciousness, …

Neuronal Birthdate Reveals Topography In A Vestibular Brainstem Circuit For Gaze Stabilization, Dena Goldblatt, Stephanie Huang, Marie R Greaney, Kyla R Hamling, Venkatakaushik Voleti, Citlali Perez-Campos, Kripa B Patel, Wenze Li, Elizabeth M C Hillman, Martha W Bagnall, David Schoppik

Faculty, Staff and Student Publications

Across the nervous system, neurons with similar attributes are topographically organized. This topography reflects developmental pressures. Oddly, vestibular (balance) nuclei are thought to be disorganized. By measuring activity in birthdated neurons, we revealed a functional map within the central vestibular projection nucleus that stabilizes gaze in the larval zebrafish. We first discovered that both somatic position and stimulus selectivity follow projection neuron birthdate. Next, with electron microscopy and loss-of-function assays, we found that patterns of peripheral innervation to projection neurons were similarly organized by birthdate. Finally, birthdate revealed spatial patterns of axonal arborization and synapse formation to projection neuron outputs. …

Targeting The Mevalonate Pathway Suppresses Arid1a-Inactivated Cancers By Promoting Pyroptosis, Wei Zhou, Heng Liu, Zhe Yuan, Joseph Zundell, Martina Towers, Jianhuang Lin, Simona Lombardi, Hao Nie, Brennah Murphy, Tyler Yang, Chen Wang, Liping Liao, Aaron R Goldman, Toshitha Kannan, Andrew V Kossenkov, Ronny Drapkin, Luis J Montaner, Daniel T Claiborne, Nan Zhang, Shuai Wu, Rugang Zhang

Faculty, Staff and Student Publications

ARID1A, encoding a subunit of the SWI/SNF complex, is mutated in ∼50% of clear cell ovarian carcinoma (OCCC) cases. Here we show that inhibition of the mevalonate pathway synergizes with immune checkpoint blockade (ICB) by driving inflammasome-regulated immunomodulating pyroptosis in ARID1A-inactivated OCCCs. SWI/SNF inactivation downregulates the rate-limiting enzymes in the mevalonate pathway such as HMGCR and HMGCS1, which creates a dependence on the residual activity of the pathway in ARID1A-inactivated cells. Inhibitors of the mevalonate pathway such as simvastatin suppresses the growth of ARID1A mutant, but not wild-type, OCCCs. In addition, simvastatin synergizes with anti-PD-L1 antibody in a genetic OCCC …

Uropathogenic Escherichia Coli Infection-Induced Epithelial Trained Immunity Impacts Urinary Tract Disease Outcome, Seongmi K Russell, Jessica K Harrison, Benjamin S Olson, Hyung Joo Lee, Valerie P O'Brien, Xiaoyun Xing, Lu Yu, Elisha D O Roberson, Rajdeep Bomjan, Changxu Fan, Marina Sha, Marco Colonna, Ting Wang, Thomas J Hannan, Scott J Hultgren, Et Al.

2020-Current year OA Pubs

Previous urinary tract infections (UTIs) can predispose one to future infections; however, the underlying mechanisms affecting recurrence are poorly understood. We previously found that UTIs in mice cause differential bladder epithelial (urothelial) remodelling, depending on disease outcome, that impacts susceptibility to recurrent UTI. Here we compared urothelial stem cell (USC) lines isolated from mice with a history of either resolved or chronic uropathogenic Escherichia coli (UPEC) infection, elucidating evidence of molecular imprinting that involved epigenetic changes, including differences in chromatin accessibility, DNA methylation and histone modification. Epigenetic marks in USCs from chronically infected mice enhanced caspase-1-mediated cell death upon UPEC …

23-35 Bridge Street Llc V. Excel Automotive Tech Center, Inc.

All Decisions

The landlord sought reimbursement for costs, disbursements, attorney's fees, and lost market rents after the lease expired, following a previous declaratory judgment. The tenant cross-moved to vacate the trial decision and sought sanctions. The court awarded the landlord costs and disbursements but denied claims for attorney's fees and lost market rents. The tenant's cross-motion to vacate the decision and for sanctions was denied. Key legal points included interpretation of lease provisions and the enforceability of an option to purchase despite late exercise.

Toward Practical Integration Of Omic And Imaging Data In Co-Clinical Trials, Emel Alkim, Heidi Dowst, Julie Dicarlo, Lacey E Dobrolecki, Anadulce Hernández-Herrera, David A Hormuth, Yuxing Liao, Apollo Mcowiti, Robia Pautler, Mothaffar Rimawi, Ashley Roark, Ramakrishnan Rajaram Srinivasan, Jack Virostko, Bing Zhang, Fei Zheng, Daniel L Rubin, Thomas E Yankeelov, Michael T Lewis

Faculty, Staff and Students Publications

Co-clinical trials are the concurrent or sequential evaluation of therapeutics in both patients clinically and patient-derived xenografts (PDX) pre-clinically, in a manner designed to match the pharmacokinetics and pharmacodynamics of the agent(s) used. The primary goal is to determine the degree to which PDX cohort responses recapitulate patient cohort responses at the phenotypic and molecular levels, such that pre-clinical and clinical trials can inform one another. A major issue is how to manage, integrate, and analyze the abundance of data generated across both spatial and temporal scales, as well as across species. To address this issue, we are developing MIRACCL …

Neuronal Birthdate Reveals Topography In A Vestibular Brainstem Circuit For Gaze Stabilization, Dena Goldblatt, Stephanie Huang, Marie R Greaney, Kyla R Hamling, Venkatakaushik Voleti, Citlali Perez-Campos, Kripa B Patel, Wenze Li, Elizabeth M C Hillman, Martha W Bagnall, David Schoppik

2020-Current year OA Pubs

Across the nervous system, neurons with similar attributes are topographically organized. This topography reflects developmental pressures. Oddly, vestibular (balance) nuclei are thought to be disorganized. By measuring activity in birthdated neurons, we revealed a functional map within the central vestibular projection nucleus that stabilizes gaze in the larval zebrafish. We first discovered that both somatic position and stimulus selectivity follow projection neuron birthdate. Next, with electron microscopy and loss-of-function assays, we found that patterns of peripheral innervation to projection neurons were similarly organized by birthdate. Finally, birthdate revealed spatial patterns of axonal arborization and synapse formation to projection neuron outputs. …

The Trouble Department: May Brotherton And The Agency Of Women Cutters In The Early Film Industry, Rachael Camp

Electronic Theses and Dissertations Archive

This study examines the pioneering film editor May Brotherton as a case study to explore how studio industrialization in pre and early Hollywood influenced the contributions of women post-production workers. It considers why film editing, once categorized as a feminized sector, was recategorized after its creative power and financial implications were realized. As a result, we may become aware of the systematic gender discrimination in studio film, as well as an extremely important but unrecognized editor. Incorporating evidence from primary and secondary sources on early film industry development, including testimony, archival artifacts, and interviews with Brotherton’s descendants. The methodology is …

Ctr. For Biological Diversity V. United States Fish & Wildlife Serv., Ali Stapleton

Public Land & Resources Law Review

The Ninth Circuit Court of Appeals affirmed the District Court of Arizona’s decision to deny a proposed mining plan becuase the operations exceeded the boundaries of a valid mining claim. The issue the court addressed is whether a permanent occupancy of waste rock and tailings on land, absent the discovery of valuable minerals, is a reasonable use related to mining activities. The Ninth Circuit decision effectively prevented mining companies from amending the 1872 Mining Law on the administrative record. Motions for a rehearing and a rehearing en banc were denied.

A Review Of Cpr Augmentation Devices, Moshe Bengio, Glenn Goodwin, Alexander Scumpia

HPD Articles

The study aims to assess cardiopulmonary resuscitation (CPR) outcomes in cardiac arrest patients when using CPR augmentation devices, such as the ZOLL ResQCPR system (Chelmsford, MA) or its components ResQPUMP and ResQPOD, which are manual active compression-decompression (ACD) device and impedance threshold device (ITD), respectively. The analysis included a Google Scholar-based literature review that took place between January 2015 and March 2023 and included recent publications with PubMed IDs or widely cited articles to assess the effectiveness of the ResQPUMP and ResQPOD or similar devices. This review also includes studies quoted by ZOLL, but those were not considered in our …

Evaluation Of Eastern Gamagrass As Dual-Purpose Complementary Bioenergy And Forage Feedstock To Switchgrass, Christina Kieffer, Dafeng Hui, Roser Matamala, Jianwei Li, Donald Tyler, E. Kudjo Dzantor

Biology Faculty Research

Switchgrass (SG) is considered a model bioenergy crop and a warm-season perennial grass (WSPG) that traditionally served as forage feedstock in the United States. To avoid the sole dependence on SG for bioenergy production, evaluation of other crops to diversify the pool of feedstock is needed. We conducted a 3-year field experiment evaluating eastern gamagrass (GG), another WSPG, as complementary feedstock to SG in one- and two-cut systems, with or without intercropping with crimson clover or hairy vetch, and under different nitrogen (N) application rates. Our results showed that GG generally produced lower biomass (by 29.5%), theoretical ethanol potential (TEP, …

Indocyanine Green-Based Glow Nanoparticles Probe For Cancer Imaging, Neeraj Chauhan, Marco A. Cabrera, Pallabita Chowdhury, Prashanth K.B. Nagesh, Anupam Dhasmana, Fnu Pranav, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu

School of Medicine Publications

Indocyanine green (ICG) is one of the FDA-approved near infra-red fluorescent (NIRF) probes for cancer imaging and image-guided surgery in the clinical setting. However, the limitations of ICG include poor photostability, high concentration toxicity, short circulation time, and poor cancer cell specificity. To overcome these hurdles, we engineered a nanoconstruct composed of poly (vinyl pyrrolidone) (PVP)-indocyanine green that is cloaked self-assembled with tannic acid (termed as indocyanine green-based glow nanoparticles probe, ICG-Glow NPs) for the cancer cell/tissue-specific targeting. The self-assembled ICG-Glow NPs were confirmed by spherical nanoparticles formation (DLS and TEM) and spectral analyses. The NIRF imaging characteristic of ICG-Glow …

Moderate-Intensity Exercise Improves Mesenteric Arterial Function In Male Uc Davis Type-2 Diabetes Mellitus (Ucd-T2dm) Rats: A Shift In The Relative Importance Of Endothelium-Derived Relaxing Factors (Edrf), Md Rahatullah Razan, Said Amissi, Rifat Ara Islam, James L. Graham, Kimber L. Stanhope, Peter J. Havel, Roshanak Rahimian

School of Pharmacy Faculty Articles

The beneficial cardiovascular effects of exercise are well documented, however the mechanisms by which exercise improves vascular function in diabetes are not fully understood. This study investigates whether there are (1) improvements in blood pressure and endothelium-dependent vasorelaxation (EDV) and (2) alterations in the relative contribution of endothelium-derived relaxing factors (EDRF) in modulating mesenteric arterial reactivity in male UC Davis type-2 diabetes mellitus (UCD-T2DM) rats, following an 8-week moderate-intensity exercise (MIE) intervention. EDV to acetylcholine (ACh) was measured before and after exposure to pharmacological inhibitors. Contractile responses to phenylephrine and myogenic tone were determined. The arterial expressions of endothelial nitric …

Biodiversity Benefits Of An Ecosystem Engineer Are Negated By An Invasive Predator, E. Claire Watersmith, Brandon Mcdonald, Jeremy Dixon, Michael V. Cove

United States Fish and Wildlife Service: Publications

Ecosystem engineers play a vital role in community assembly by modifying the environment to create novel habitat features. Woodrats (Neotoma sp.) build and maintain intricate stick-nests that stockpile organic materials and create habitat for other small species. The Key Largo woodrat (Neotoma floridana smalli) is an endangered subspecies endemic to Key Largo, Florida, USA, that has undergone substantial declines due to habitat loss and predation by invasive predators. We leveraged data from a camera trap monitoring grid at supplemental woodrat nest structures to survey bird communities to evaluate the role of woodrat nest use and stick-nest building …

Co-Exploring Meaning In Everyday Life For People In Mental Health Recovery: A Photovoice Study, Siw H. Tønnessen, Ottar Ness, Trude G. Klevan

The Qualitative Report

Research on mental health recovery points to an interdependent relationship between experiences of meaning and experiences of recovery; meaning in everyday life promotes recovery, and recovery promotes meaning in everyday life. In this study we address the following question: What do people with mental challenges find meaningful in their everyday life? To explore this question, we offered disposable cameras to people with mental health challenges and asked them to photograph whatever makes their life meaningful. As part of the collaborative procedure of the study, a competence group contributed to different stages of the research process and the visual data were …

A Hybrid Mcdm Approach For Industrial Robots Selection For The Automotive Industry, Abduallah Gamal, Mona Mohamed

Neutrosophic Systems with Applications

The use of robots in various stages of the production process is now commonplace across practically all sectors of the economy. Additionally, even for present-day small and medium-sized businesses, this has developed into a very powerful need in recent years and continues to grow in importance. The selection of an industrial robot is a very complicated decision-making issue due to the fact that there are numerous aspects and criteria that are in conflict with one another, as almost all of the earlier research emphasized. In addition, the many sophisticated requirements that have been added to these robots by the makers …

Pengaruh Perbedaan Lokasi Mencari Makan Terhadap Keragaman Mangsa Tiga Jenis Kuntul Di Cagar Alam Pulau Dua Serang: Casmerodius Albus, Egretta Garzetta, Bubulcus Ibis, Dewi Elfidasari

Makara Journal of Science

Prey diversity influenced by the different or foraging areas for three species herons in Cagar Alam Pulau Dua Serang. This research is to know the influenced of foraging areas to prey diversity for three species herons in Cagar Alam Pulau Dua Serang, Banten Province. This research have been done at feeding area for the herons around Cagar Alam Pulau Dua. The data were from film shooting use Focal Observation Methods, while the film shooting analyze use scan sampling methods. It’s explain that Casmerodius albus and Egretta garzetta have preferency to select the mudflat and fisheries around CAPD as foranging location …

Pengaruh Perbedaan Lokasi Mencari Makan Terhadap Keragaman Mangsa Tiga Jenis Kuntul Di Cagar Alam Pulau Dua Serang: Casmerodius Albus, Egretta Garzetta, Bubulcus Ibis, Dewi Elfidasari

Makara Journal of Science

Prey diversity influenced by the different or foraging areas for three species herons in Cagar Alam Pulau Dua Serang. This research is to know the influenced of foraging areas to prey diversity for three species herons in Cagar Alam Pulau Dua Serang, Banten Province. This research have been done at feeding area for the herons around Cagar Alam Pulau Dua. The data were from film shooting use Focal Observation Methods, while the film shooting analyze use scan sampling methods. It’s explain that Casmerodius albus and Egretta garzetta have preferency to select the mudflat and fisheries around CAPD as foranging location …

Sr 22-23-39 Cc, Marshall University Faculty Senate

Recommendations

No abstract provided.

Sr 22-23-40 Cc, Marshall University Faculty Senate

Recommendations

No abstract provided.

Understanding And Mitigating Thiaminase Activity In Silver Carp, Patricia C. Wolfe, Amber M. Tuske, Donald E. Tillitt, Fred Allen, Katie A. Edwards

Pharmacy Faculty Scholarship

A deficiency of thiamine (vitamin B1), an essential cofactor for enzymes involved in metabolic processes, can be caused by the enzyme thiaminase. Thiaminase in food stocks has been linked to morbidity and mortality due to thiamine depletion in many ecologically and economically important species. Thiaminase activity has been detected in certain bacteria, plants, and fish species, including carp. The invasive silver carp (Hypophthalmichthys molitrix) presents an enormous burden to ecosystems throughout the Mississippi River watershed. Its large biomass and nutritional content offer an attractive possibility as a food source for humans, wild animals, or pets. Additionally, harvesting this fish could …

Human Cytomegalovirus (Cmv) Infection Associated With Decreased Risk Of Bronchogenic Carcinoma: Understanding How A Previous Cmv Infection Leads To An Enhanced Immune Response Against Malignancy., Selena Rashid, Amalia Ardeljan, Lexi R. Frankel, Matthew Cardeiro, Enoch Kim, Brittany M. Nagel, Kazuaki Takabe, Omar Rashid

HPD Articles

INTRODUCTION:  Cytomegalovirus (CMV) causes a long-lasting, asymptomatic infection that reportedly has both advantageous and deleterious effects on tumor progression. The purpose of this study was to evaluate the correlation between CMV infection and the incidence of bronchogenic carcinoma.

METHODS: The study was conducted using a Health Insurance Portability and Accountability Act (HIPAA) compliant national database to identify patients both with and without histories of CMV infection using International Classification of Diseases (ICD-10 and ICD-9) codes. Access to the database was granted by Holy Cross Health, Fort Lauderdale for the purpose of academic research with standard statistical methods used to analyze …

Lesson Plan: Create A Terrarium And Marshmallow Tower To Observe, Plan, And Execute A Design, Claudia Soto, Nancy Farhoud, Jasmin Barajas, John Pham, Yifeng Liu, Robin Jocius

STEAM Project Student Publications - Archive

This lesson focuses on forces and motion. Students apply creativity and experimentation to describe the movement of matter among animals, plants, decomposers, and the environment. To summarize their learning, students craft a marshmallow tower and create a terrarium.

By creating a terrarium and marshmallow tower, students will understand how to observe, plan, and execute a design while exploring concepts related to biology, engineering, and creative problem solving. How can we use our observations and creativity to design and build a terrarium and a stable marshmallow tower using toothpicks and marshmallows? This essential question encourages students to use critical thinking and …

2023 Lynn University Student Symposium: A Presentation Of Research Projects, Lynn University

Student Research Symposium Programs

2023 Lynn University Student Symposium Program, hosted by The College of Arts and Sciences

Gender Identity And The Impact On The Mental Health Crisis, Melissa Nicole Herbolsheimer

Masters Theses

Adolescents' mental health has been at the forefront of counseling for many years. As adolescents endure the physical and hormonal changes that occur during the formative years from 10-19, many feel confused and uncomfortable in their bodies. Throughout the decades, adolescents, specifically girls, searched for a way to ease the feelings experienced during that time. As a result, many issues have been prevalent among adolescent girls, such as eating disorders, cutting, suicidal ideations, sexual activity, and gender dysphoria. Utilizing studies completed by mental health professionals, this thesis seeks to identify the impact this acceptance and freedom to choose one’s gender …