Digital Commons Network^™

Structural Foundations Of Potassium Selectivity In Channelrhodopsins, Sukyeong Lee, Sang Bum Lee, Nuri Sung, Wendy W Xu, Changsoo Chang, Hyun-Eui Kim, Andre Catic, Francis T F Tsai

Faculty, Staff and Student Publications

Mitochondria are critical to cellular and organismal health. To prevent damage, mitochondria have evolved protein quality control machines to survey and maintain the mitochondrial proteome. SKD3, also known as CLPB, is a ring-forming, ATP-fueled protein disaggregase essential for preserving mitochondrial integrity and structure. SKD3 deficiency causes 3-methylglutaconic aciduria type VII (MGCA7) and early death in infants, while mutations in the ATPase domain impair protein disaggregation with the observed loss-of-function correlating with disease severity. How mutations in the non-catalytic N-domain cause disease is unknown. Here, we show that the disease-associated N-domain mutation, Y272C, forms an intramolecular disulfide bond with Cys267 and …

Sting-Dependent Interferon Signatures Restrict Osteoclast Differentiation And Bone Loss In Mice, Susan Maclauchlan, Priyanka Kushwaha, Albert Tai, Sijia Chen, Catherine Manning, Gaurav Swarnkar, Yousef Abu-Amer, Katherine A Fitzgerald, Shruti Sharma, Ellen M Gravallese

2020-Current year OA Pubs

Stimulator of interferon genes (STING) is a key mediator of type-I interferon (IFN-I) signaling in response to a variety of stimuli, but the contribution of STING to homeostatic processes is not fully characterized. Previous studies showed that ligand activation of STING limits osteoclast differentiation in vitro through the induction of IFNβ and IFN-I interferon-stimulated genes (ISGs). In a disease model (SAVI) driven by the V154M gain-of-function mutation in STING, fewer osteoclasts form from SAVI precursors in response to receptor activator of NF-kappaB ligand (RANKL) in an IFN-I-dependent manner. Due to the described role of STING-mediated regulation of osteoclastogenesis in activation …

Foxi3 Pathogenic Variants Cause One Form Of Craniofacial Microsomia, Ke Mao, Christelle Borel, Muhammad Ansar, Angad Jolly, Periklis Makrythanasis, Christine Froehlich, Justyna Iwaszkiewicz, Bingqing Wang, Xiaopeng Xu, Qiang Li, Xavier Blanc, Hao Zhu, Qi Chen, Fujun Jin, Harinarayana Ankamreddy, Sunita Singh, Hongyuan Zhang, Xiaogang Wang, Peiwei Chen, Emmanuelle Ranza, Sohail Aziz Paracha, Syed Fahim Shah, Valentina Guida, Francesca Piceci-Sparascio, Daniela Melis, Bruno Dallapiccola, Maria Cristina Digilio, Antonio Novelli, Monia Magliozzi, Maria Teresa Fadda, Haley Streff, Keren Machol, Richard A Lewis, Vincent Zoete, Gabriella Maria Squeo, Paolo Prontera, Giorgia Mancano, Giulia Gori, Milena Mariani, Angelo Selicorni, Stavroula Psoni, Helen Fryssira, Sofia Douzgou, Sandrine Marlin, Saskia Biskup, Alessandro De Luca, Giuseppe Merla, Shouqin Zhao, Timothy C Cox, Andrew K Groves, James R Lupski, Qingguo Zhang, Yong-Biao Zhang, Stylianos E Antonarakis

Faculty, Staff and Students Publications

Craniofacial microsomia (CFM; also known as Goldenhar syndrome), is a craniofacial developmental disorder of variable expressivity and severity with a recognizable set of abnormalities. These birth defects are associated with structures derived from the first and second pharyngeal arches, can occur unilaterally and include ear dysplasia, microtia, preauricular tags and pits, facial asymmetry and other malformations. The inheritance pattern is controversial, and the molecular etiology of this syndrome is largely unknown. A total of 670 patients belonging to unrelated pedigrees with European and Chinese ancestry with CFM, are investigated. We identify 18 likely pathogenic variants in 21 probands (3.1%) in …

320 E. 73, Llc V. Alfredo

All Decisions

No abstract provided.

Information Ecology For Effective Knowledge Management In 21st Century, Jamilu Isah

Library Philosophy and Practice (e-journal)

Abstract: This paper is an opinion paper design to provides a conceptual framework on information ecology for effective knowledge management in 21^st century. itconsiders the creation of knowledge, and the flow of information within the society and organization. The paper hopes to encourage readers of any organizational setting on how to become accustomed to the information ecology to survive in knowledge management and competitive atmosphere. For that, based on literature review, the main elements of the information ecology in 21st century, knowledge and knowledge management, information ecology and technology, challenges of information ecology and knowledge management in 21^{st …}

Sailing Towards Freedom: Discourses Of Domination And Resistance In Online Piracy Communities, Lewie Andrew Carmichael

Electronic Theses and Dissertations Archive

For this study, 22 people over 18 years of age who illicitly downloaded media, sometimes called ‘pirates,’ were interviewed to explore how they accounted for their behavior and their communities. They claimed poverty, convenience, habit, archiving, and fun as their primary motivations for piracy. A Pirate Bill of Rights is proposed to represent foundational ethics from which many participants drew their basic moral and ethical assumptions. James C. Scott’s transcript theory is used to frame how pirates perceive domination and how piracy acts as a form of resistance against it. The concepts of the ‘pirate other’ and the ‘corporate other’ …

Impact Of Particle Sizes On Mri Signal Relaxation In Phantoms For Assessment Of Hepatic Steatosis And Iron Overload, Sarah Caroline Brasher

Electronic Theses and Dissertations Archive

Magnetic Resonance Imaging (MRI) is emerging as a powerful tool to non-invasively evaluate diffuse liver diseases such as hepatic steatosis and iron overload. To test new MRI techniques, phantom studies are utilized in place of patients but often do not consider the microscopic interactions of particles suspended in the media which may cause a notable difference in the signal. Hence, this study investigates the impact of differing particle sizes on the magnetic resonance signal using phantoms. To accomplish this, steatosis phantoms were created using two different mixing methods to control droplet size and while combination iron-fat phantoms featuring iron particles …

Neutrosophic Marcos In Decision Making On Smart Manufacturing System, Nivetha Martin, Said Broumi, S. Sudha, R. Priya

Neutrosophic Systems with Applications

Business firms prefer software-based smart manufacturing systems to monitor and supervise all production activities in a decentralized manner. The choice of software decides the degree of manufacturing robustness. This paper proposes a neutrosophic-based MARCOS (Measurement of Alternatives and Ranking according to COmpromise Solution) method of MCDM with single-valued triangular neutrosophic numbers to solve the software selection problem. The proposed neutrosophic method is applied to hypothetical data to test the efficacy of the method. The results obtained using the proposed method are compared with crisp, fuzzy, and intuitionistic data representations, and suitable inferences are acquired. The proposed method has several industrial …

Evaluating The Past And Charting The Future Of Human Rights Education, J. Paul Martin, Snigdha Dutt

International Journal of Human Rights Education

This article provides an overview of the field of human rights education (HRE) using an input/output schema. It examines the challenges encountered at the delivery points where instructors must contextualize the now extensive corpus of human rights documents and practices to meet the needs, and the political and cultural traditions, of their particular target population. The challenges also point to the dominance of prescriptive over evaluative HRE literature, the degree to which HRE is not a stand-alone activity and the limited HRE-specific teacher training. The authors therefore call for more research on the long-term HRE outcomes of human rights education …

Ordinary Solidarities: Re-Reading Refugee Education Response Through An Anticolonial Discursive Framework, Zeena Zakharia

International Journal of Human Rights Education

Growing attention to longstanding issues linked to racism and coloniality in humanitarian assistance has impelled important conversations about power inequities in global education spaces and their related scholarly fields. This paper contributes to these conversations by advancing an anticolonial discursive framework for rights-based interventions in and through education. Drawing on a three-year case study of one faith-based school in Lebanon, this paper explores how one ordinary school in a refugee hostile transit country secured and protected the right to education for refugee children from Syria, within a significant broader context of multiple compounding crises. The notion of “ordinary solidarities” is …

Forecasting Winners And Losers Of Climate Change: Insights From The Interactions Between Organisms And Their Microclimates, Michael Sears

Sustainability Seminar Series

Meaningful forecasts of the responses of organisms to climate require an explicit understanding of how organismal behavior and physiology are affected by environmental heterogeneity. Such predictions are complicated because physiology and behavior vary over different time scales, vary across different life stages, and do not operate in isolation of one another. In this talk, I review case studies from my lab to highlight progress that has been made along these fronts and provide generalizations that might be made to other systems, particularly in the context of predicting responses to climate change.

Retaggio, Divya Mehrish

The Woodward Review: A Creative and Critical Journal

No abstract provided.

Full Issue: The Woodward Review 2.2, Spring 2023

The Woodward Review: A Creative and Critical Journal

No abstract provided.

An Early Enriched Diet And Its Effect On Invertebrates (Blaberus Discoidalus), Diego De Gregorio

2023 Student Academic Showcase

Research with multiple animal species suggests that experiencing enriched diets and environmental conditions during early development facilitates positive outcomes in neurogenesis, associative learning, and memory (Cayre et al., 2007; Maegele et al., 2015; Mallory et al., 2016), social behavior (Oddi et al., 2015), and sensory system function (Leong et al., 2015). Whether the developmental gains that enriched environments provide apply similarly to all invertebrate species remains unknown. This study will help close this gap in the literature. To answer our research question, 120 nymph cockroaches were randomly assigned to one of three experimental conditions (40 subjects per condition) in which …

Agricultural Literacy And Food Production In Nigeria, Tor-Akwer Helen Famaren, Dominic Aondohemba Ihongo, Comfort Member Tyopev

Library Philosophy and Practice (e-journal)

There are growing concerns relating to current Nigerian agricultural food production practices and its impact on human nutrition. There is mounting evince that our current food system is responsible for diseases such as diabetes and obesity. Agricultural literacy is possessing knowledge and understanding of our food and fiber system. For citizens to be minimally educated about agricultural practices, agricultural literacy is important for both the individual and for the industries. An individual must be well informed to make responsible choices in matters of food and fiber. Improving agricultural literacy by understanding the needs of the society, as it relates to …

Habitat Effects On Scorpion Densities And Microhabitat Use By Centruroides Vittatus And Vaejovis Waueri In South Texas, Jonathan Beltran

Theses and Dissertations

Co-existence between Centruroides vittatus and Vaejovis waueri is influenced by environmental factors that shape their habitats. Differences in surface activity frequency between the two species suggest differential microhabitat use. The observed frequency of scorpions using microhabitats in the Martinez Ranch and La Union Ranch were not significantly different from the expected frequencies. Frequency of scorpions observed using microhabitats in La Union South was significantly different from the expected frequency (P<0.001). Microhabitat use of catclaw was lower than expected and higher than expected for other vegetation. Conditional comparisons of microhabitats were significantly different among habitats (P<0.001), size classes were significantly different among microhabitats (P<0.001), and size classes were significantly different among habitats (P<0.01). Microhabitat use by scorpions on the ground was higher among all habitats. Scorpion use of ground and grass were different among size classes. Size class I-II scorpions had a higher frequency than size class III. Scorpion density for C. vittatus was significantly different among habitats (P<0.0001) and scorpion density for V. waueri was significantly different among habitats (P<0.0001). Centruroides vittatus was significantly higher in the Martinez Ranch and in La Union South. Vaejovis waueri was significantly higher in La iv Union South. Associations between plant densities and scorpion size classes were tested. Plant densities had a significant association with C. vittatus size classes I and II in the Martinez Ranch. Association between plants had a significant correlation with C. vittatus size classes I and IV in La Union Ranch. Association between plants had a significant correlation with V. waueri’s total density. These associations may suggest plant densities may have a synergistic effect on scorpion densities. Soil type composition for the different habitats was hypothesized to influence scorpion densities. Maps for each site were created to show soil type compositions. Soil type findings suggest that La Union South had the soil types with the lowest soil strength. Vaejovis waueri was shown to have a higher density in La Union South where soils are sandier. Results indicate that co-existence between C. vittatus and V. waueri is possible because competition is low through minimal overlap in microhabitat use and intraguild predation avoidance.

Mindo Y Baños, Cassie Klagge

2022-23 Postcards

Postcard from Cassie Klagge, during the Linfield University Spring Semester Abroad at University of San Francisco de Quito in Ecuador.

Am I Another You?, Laura Diane Cobb

School of Art, Art History, and Design: Theses and Student Creative Work

On my birth certificate are the names of my parents, though the name of my father stands in opposition to my genealogy. The script of his signature conceals my birth as donor conceived (DC). The truth of my origin would lay dormant for years behind his scrawl, burying my true heritage beneath the stories of my social father’s ancestry.

Learning the truth, I began to reevaluate my identity. Searching for myself along waterways, I explored the shores of the Platte River as if by knowing its sandbars, flora, and fauna, I would come to know myself. In searching the land, …

The Utah Statesman, April 10, 2023, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

2023 Forces, R. Scott Yarbrough

Forces

No abstract provided.

Comprehensive Review Of Acute Pancreatitis Pain Syndrome, Jacob Beiriger, Adnan Khan, Brian Yan, Heather Ross, Makala Wang, Michael Carducci, Natali Salinas, Salil Chowdhury, Ryan Erwin, Sarah Chen, Alexis Gerber

Jefferson Hospital Staff Papers and Presentations

Pancreatitis is a condition that causes inflammation in the pancreas, an organ located behind the stomach. This condition often presents as neuropathic, inflammatory, and/or visceral pain. Acute pancreatitis is typically characterized by sudden and severe abdominal pain, often in the upper right part of the abdomen. The pain from pancreatitis can be caused by different mechanisms, such as abnormal activation of pancreatic zymogens or NF-κB mediated inflammation in the pancreas. The treatment of pancreatitis depends on its type, severity, and underlying cause. Hospitalization and medications are typically necessary, while in others, surgery may be required. Proper management of pancreatitis is …

Body In Rebellion: The Closing Body, Romantic Mesmerism, And Gothic Doubles In Hogg's Justified Sinner, Elizabeth E. Hinds

Theses and Dissertations

This study explores the western Romantic period as a transition between the medieval “open body” and the modern “closed body.” It focuses on “closing body” phenomena such as “mesmerism” (i.e. animal magnetism), somnambulism, substance abuse, and the “second-self,” including notions of the subconscious and the trope of gothic Doppelgängers. This study draws from many pieces of western Romantic literature but is most centered around James Hogg’s 1824 The Private Memoirs and Confessions of a Justified Sinner. This new reading of Hogg’s novel suggests a core theme of body anxiety, rather than theological dispute.

Mandala: On The Logos Of Place, Michael Schwartz

Journal of Conscious Evolution

Suddenly, during the night, one awakens while dreaming – aware that this is a dream. The “rules” of action, reaction, and of form itself are not that of the waking state – one might leap in the air and fly, transform one’s body into any number of forms, reach up in the sky and grab the sun and clouds, pulling them to the side, bringing forth a canopy of moon and stars. The entire scene, in the lucid dream, has a heightened sense of radiance and joy, vitality and freedom.

Imagine this sense of lucid dreaming is occurring right here …

Electrodermal Activity In Response To Stress Reduction: Virtual Reality Experience In Hydrotherapy And Non-Hydrotherapy Environments, Nthabeleng Macdonald

Undergraduate University Honors Capstones

Hydrotherapy, a holistic alternative medicine, uses methods like water therapy, cold water immersion, and balneotherapy to treat physical and mental illnesses while inducing tranquility (Bahadorfar, 2014). In this study, the water therapy approach was used, but with a unique twist. Rather than traditional hydrotherapy involving direct contact with water, participants were fully immersed in a virtual reality water environment. This study investigated whether immersing individuals with psychological stress in an underwater environment via virtual reality (VR) reduces their stress levels as compared to a non-hydrotherapy virtual city environment. The effects of underwater scenery versus non-hydrotherapy city scenery individuals experiencing stress …

Easy And Quick Binding Of Targeting Molecule And Radiotracer To Drug Nanocarrier For Cancer Therapy, Jeff Hansen

Browse All News

No abstract provided.

Hawks' Herald -- Apr. 10, 2023, Roger Williams University

Hawk's Herald

No abstract provided.

A Ferritin Nanoparticle-Based Zika Virus Vaccine Candidate Induces Robust Humoral And Cellular Immune Responses And Protects Mice From Lethal Virus Challenge, Aryamav Pattnaik, Bikash R. Sahoo, Lucas R. Struble, Gloria E. O. Borgstahl, You Zhou, Rodrigo Franco, Raul G. Barletta, Fernando A. Osorio, Thomas M. Petro, Asit K. Pattnaik

School of Veterinary and Biomedical Sciences: Faculty Publications

The severe consequences of the Zika virus (ZIKV) infections resulting in congenital Zika syndrome in infants and the autoimmune Guillain–Barre syndrome in adults warrant the development of safe and efficacious vaccines and therapeutics. Currently, there are no approved treatment options for ZIKV infection. Herein, we describe the development of a bacterial ferritin-based nanoparticle vaccine candidate for ZIKV. The viral envelope (E) protein domain III (DIII) was fused in-frame at the amino-terminus of ferritin. The resulting nanoparticle displaying the DIII was examined for its ability to induce immune responses and protect vaccinated animals upon lethal virus challenge. Our results show that …

The Genomics Of Autism-Related Genes Il1rapl1 And Il1rapl2: Insights Into Their Cortical Distribution, Cell-Type Specificity, And Developmental Trajectories, Jacob Weaver

MUSC Theses and Dissertations

Neuropsychiatric disorders have a significant impact on modern society. These disorders affect a large percentage of the population: schizophrenia has a world-wide prevalence of 1% and autism spectrum disorders (ASD) affects 1 in 59 school-aged children in the US. There is substantial evidence that most neuropsychiatric disorders have a genetic component. Thus, with the advent of high throughput sequencing much effort has gone into identifying genetic variants associated with these disorders. The emerging picture from these studies is a complex one where hundreds of genes with small effects interact with a varied landscape of common variants to result in disease. …

Automated Sensing Methods In Soft Stretchable Sensors For Soft Robotic Gripper, Prosenjit Kumar Ghosh

Electrical Engineering Theses

A soft robot is made from deformable and flexible materials such as silicone, rubber, polymers, etc. Soft robotics is a rapidly evolving field where the human-robot-interaction and bio-inspired design align. The physical characteristics such as highly deformable material and dexterity make soft robots widely applicable. A soft robotic gripper is a robotic hand that acts like a human hand and grasps any object. The most common applications of soft robotics grippers are gripping and locomotion in sensitive applications where high dynamic and sensitivity are essential. Nowadays, soft robotics grippers are used without any sensing method and feedback as it is …

Membership Probabilities Of White Dwarfs In Open Star Clusters, Sarah Phillips

Honors Theses

This thesis explores the relationship between astronomical position data and star cluster membership. Our research project focuses on the mathematical probability of cluster membership for white dwarf stars (WDs), specifically membership candidates within the open cluster Messier 35. Through Gaussian analysis of proper motion data, we examine the membership probability of each candidate. Establishing cluster membership has broad applications and can allow further determination of a star’s characteristics including stellar age and evolution. Of particular interest are two WD member candidates for Messier 35: LAWDS 4, a DB WD with a helium-dominated atmosphere as opposed to the more common hydrogen-dominated …