Digital Commons Network^™

The Effects Of A Blood–Brain Barrier Penetrating Erythropoietin In A Mouse Model Of Tauopathy, Joshua Yang, Weijun Ou, Nataraj Jagadeesan, Juste Simanauskaite, Jiahong Sun, Demi M. Castellanos, David H. Cribbs, Rachita K. Sumbria

Pharmacy Faculty Articles and Research

Erythropoietin (EPO), a hematopoietic neurotrophin, is a potential therapeutic for Alzheimer’s disease (AD) but has limited blood–brain barrier (BBB) permeability. EPO fused to a chimeric transferrin receptor monoclonal antibody (cTfRMAb) enters the brain via TfR-mediated transcytosis across the BBB. We previously showed that cTfRMAb-EPO is protective in a mouse model of amyloidosis, but its effects on tauopathy are not known. Given that amyloid and tau pathology are characteristics of AD, the effects of cTfRMAb-EPO were studied in a tauopathy mouse model (PS19). Six-month-old PS19 mice were injected intraperitoneally with either saline (PS19-Saline; n = 9) or cTfRMAb-EPO (PS19-cTfRMAb-EPO, 10 mg/kg; …

A Phenomenological Study Of Parents Accessing And Receiving Professional Care For Their Child With Autism Spectrum Disorder (Asd) During The Covid-19 Outbreak In Washington State, Patrick Michael Barry

Doctoral Dissertations and Projects

COVID-19 changes and restrictions have necessitated a change in the way schools, mental health providers, medical providers, and other educational and therapy services provide for children with autism. This study explores, in-depth, the experience of parents of children with ASD as they have navigated the COVID-19 required changes to professional treatment and services for children with ASD and their families. Research suggests that raising a child with an autism spectrum disorder (ASD) can be an overwhelming experience for parents and families, and greater family burden is positively associated with the number of unmet professional help service needs. As services were …

Effects Of Emr On Community Health Center Communication, John M. Boyke

Doctoral Dissertations and Projects

Electronic medical record (EMR) systems impact healthcare communication in a significant number of ways. The physical presence of the EMR in the examination room can negatively impacts patient-provider communication. This research examined the impact of EMR on patient-provider communication within the microcosm of the community health center. The data for this research was collected via a quantitative survey using a random sample of 513 (10%) of the 5,101 patients of the Northwest Community Health Center (August 2021 to August 2022). These participants were at least 18 years of age and had seen their medical provider in the previous 12 months. …

The Differentiation And Quantification Of Bacterial Colonies Cultured On Plant Based Yogurt And Animal Based Yogurt, Nicolas Egros, Ishita Nair, Akeeme Brown, Cassandra S. Korte

Student Publications and Presentations

The variety of dairy products available on the market have now changed with the advent of alternative plant derived milks. Many believe that these plant based milks may be a healthier and a more sustainable option in contrast to dairy products. The production of both respective types of yogurts requires fermentation which is a process that is carried out by bacteria, hence the presence of live cultures. Fermentation of dairy products is a result of lactose sugars being metabolized by bacteria, probiotics, of which the final metabolic product is lactic acid. Due to the popularity of alternative yogurt, it is …

A Cross-Sectional Examination Of Wrist Wrap Use Prevalence And Characterization For Ergogenic Purposes In Actively Competing Powerlifters, Dillon Harris, Thomas Cardaci, Harry Cintineo, Richard Pham, Kristen Dunsmore, Leslee Funderburk, Steven Machek

Faculty Scholarship

Purpose: Wrist wraps are regularly incorporated by competitive powerlifters, but several product-specific variations may influence any potential ergogenic benefits. In addition, the prevalence of athletic wrist wrap use is hitherto undescribed.

Methods: Seventy actively competing powerlifters (n=70; 27±6y) who competed in the last two years were randomly recruited at sanctioned meets, whereby wrist wrap use descriptive data (wrap style [F or S], wrap length, and events used), wrap tightness (assessed via pulse oximeter-detected oxygen saturation (SpO2) and subjective discomfort [Borg CR10+]), as well as post-meet bench press one repetition maximum (1RM) were collected. Wrist wrap use prevalence data (wrap …

Folsom Activity, Mobility, And Flaked Stone Technological Organization At The Rio Rancho Folsom Site, New Mexico Locus 4147 And As-2, William A. Skidmore-Farren

Anthropology Graduate Student Publications

What are the similarities and differences within locus 4147/AS-2 technological organization? Determining the function of the site may reveal new adaptive strategies used by Paleoindian groups and perhaps tell us more about their social and technological organization. By measuring, identifying, analyzing, and comparing the lithic components of the locus 4147/AS-2, I hope to further our understanding of the Rio Rancho site’s function and technological organization. A study of the spatial distribution of various artifact types within the locus will also help determine the function. Chemical (XRF) and physical analysis of the variety of lithic materials from the sites will also …

Comparison Of Measurement Accuracy Between Caliper And Iphone Apps, Taryn Lagor, Alanna L. Lecher, April Watson

Student Publications and Presentations

Measuring artifacts is a fundamental method of archeological research. Measurements assist scientists in gaining knowledge about past human-animal interactions, the effects of those interactions on ecosystems, environmental changes over time, changes in ecological resources, and more. The caliper is the traditional tool for such work, but it is uncommon for scientists to carry a caliper around in their bag or pocket while in the field. There is a tool, however, that almost every person carries around with them constantly: the smartphone. In this experiment we endeavored to discover if two measuring apps, the “Ruler” app and the “ARuler” app would …

Calcium Ions Effect On Planaria Feeding Behavior, Jonathan Newman, Anden Velez, Cassandra S. Korte

Student Publications and Presentations

Calcium is important for the contraction of muscles, neurotransmission, and signaling in animals. Like other active movers, invertebrate planarian flatworms have musculature for motility. Therefore, it can be inferred that without the proper concentration of calcium ions in the water they can’t undulate or extend the pharynx, a muscular feeding structure. Planaria are generally cultured at a 0.5 g/L concentration of instant ocean sea salt (IOS), which contains calcium ion of 0.126 mM. However, there is uncertainty in the concentrations of important ions, such as calcium, which are optimal for the maintenance and homeostasis of the planaria. Previous research on …

A Visual Zooarchaeology Guide For Florida Artifacts, Brian Manzanares, Ivett De La Rosa, Maria Gabriella Almeida, Alanna L. Lecher

Student Publications and Presentations

One key factor of archeology research is discovering the faunal bones at excavation sites and seeing what lived many years ago. Faunal remains are bones, hair, shells, and more, any piece of animal anatomy. Discovering the different types of bones at excavations in Florida can give archeologists a sense of the different species in this state that were utilized by humans in the past. This study is creating a visual guide and key for faunal bone artifacts in south Florida. The key will consist of photos of bone artifacts excavated in south Florida of different types of fish and other …

Cell-Specific Role Of Il4rα Signaling In Allergic Asthma, Ishita Choudhary

LSU Doctoral Dissertations

IL-4 and IL-13 play a critical role in allergic asthma pathogenesis via their common receptor, i.e., interleukin 4 receptor alpha (IL4Rα). However, the cell type-specific role of IL4Rα-mediated signaling in allergic asthma has remained unclear. We hypothesized that the role of IL4Rα signaling in allergic asthma is cell-type specific. To test our hypothesis, we challenged myeloid cell-specific IL4Rα-deficient (LysMcre^+/+/IL4Rα^fl/fl), myeloid cell-specific IL4Rα-sufficient (LysMcre^+/+/IL4Rα^wt/wt), airway epithelial cell-specific IL4Rα-deficient (CCSP-Cre⁺/IL4Rα^fl/fl), and airway epithelial cell-specific IL4Rα-sufficient (CCSP-Cre^-/IL4Rα^fl/fl) mice with either mixed allergens (MA) or normal saline three …

Mental Health Service Preferences Among Illinois Dairy Producers: A Best-Worst Scaling Approach, Brianna Messman

Theses and Dissertations

Importance of mental health within the agricultural community is growing, especially amongst dairy farmers. With the ongoing trend of negative economic returns facing the dairy industry, there is no better time to address mental health concerns of dairy producers. The goal of this study is to gain insight into the preferred services for mental health assistance amongst Illinois dairy producers. A questionnaire was administered to Illinois dairy producers and analyzed to acquire a greater understanding of this topic. The findings from this study have the potential to assist policy makers and benefit agricultural producers. An overwhelming preference among Illinois dairy …

Volume Cxlii, Number 17, April 7, 2023, Lawrence University

The Lawrentian

No abstract provided.

Nous Sommes Tous Des « Djadjas » : La Question De L’Identité Dans La Musique Française Et Francophone Au 21^E Siècle, Molly Earle

Honors Theses

Le titre de mon travail fait référence à une chanson qui représente les thèmes de la race,1 du genre, de la transculturalité et de la collaboration musicale : « Djadja », une chanson écrite par la chanteuse franco-malienne Aya Nakamura qui a eu beaucoup de succès en 2018 et puis en 2020 avec le remix en duo avec Maluma, un chanteur colombien. Comme d’autres chansons de Nakamura, « Djadja » utilise des sons africains et urbains, mais l’ajout d’influences latino-américaines a aidé la chanson à toucher une plus grande partie du monde (Nakamura et Maluma). Par exemple, cette chanson est …

Real-Time Imaging And Measurement Of Compartmentalized Redox Shifts Using Novel Redox-Sensitive Biosensors: Implications In Developmental Toxicology, Brandon Mitchell Davies

Theses and Dissertations

Glutathione (GSH) is a small antioxidant in the body and exists in large quantities compared to other antioxidants. The GSH redox state (Eh) helps developmental processes, however, when the GSH Eh is disrupted, cells may undergo significantly poor developmental pathways, possibly leading to long-lasting damages. Similarly, NADPH and Thioredoxin redox states can have a major impact on cellular function, viability, and response to both endogenous and exogenous toxicants. Subcellular, compartmentalized redox environments during normal or perturbed situations, specifically in the cytosol, mitochondria, and nucleus, are not well understood. Here, using the P19 neurogenesis model of cellular differentiation, the kinetics of …

Primary Bilateral Macronodular Adrenocortical Hyperplasia (Pbmah) Patient With Armc5 Mutations., Peng Tang, Jun Zhang, Song Peng, Xuzhi Yan, Yapeng Wang, Shuo Wang, Yao Zhang, Gaolei Liu, Jing Xu, Yiqiang Huang, Dianzheng Zhang, Qiuli Liu, Jun Jiang, Weihua Lan

PCOM Scholarly Works

BACKGROUND: Primary bilateral macronodular adrenocortical hyperplasia (PBMAH) is a highly heterogeneous disease with divergent manifestations ranging from asymptomatic subclinical Cushing syndrome (CS) to overt Cushing syndrome with severe complications. ARMC5 mutations occur in 20 to 55% PBMAH patients usually with more severe phenotypes. Different ARMC5 mutations might be associated with diverse phenotypes of PBMAH.

CASE PRESENTATION: A 39-year-old man was admitted to our hospital with progressive weight gain and severe hypertension. He presented typical CS and its classical metabolic and bone complications like hypertension and osteoporosis. The laboratory results showed high levels of cortisol and low levels of ACTH. Low- …

The Methylation Landscape Of Giga-Genome And The Epigenetic Timer Of Age In Chinese Pine, Jiang Li, Fangxu Han, Tongqi Yuan, Wei Li, Yue Li, Harry X. Wu, Hairong Wei, Shihui Niu

Michigan Tech Publications, Part 1

Epigenetics has been revealed to play a crucial role in the long-term memory in plants. However, little is known about whether the epigenetic modifications occur with age progressively in conifers. Here, we present the single-base resolution DNA methylation landscapes of the 25-gigabase Chinese pine (Pinus tabuliformis) genome at different ages. The result shows that DNA methylation is closely coupled with the regulation of gene transcription. The age-dependent methylation profile with a linearly increasing trend is the most significant pattern of DMRs between ages. Two segments at the five-prime end of the first ultra-long intron in DAL1, a conservative age biomarker …

What Constitutes A Community? A Co-Occurrence Exploration Of The Costa Rican Avifauna, Mélusine F. Velde, Elizabeth M. Besozzi, Billi A. Krochuk, Kate M. Henderson, Brian R. Tsuru, Sara Velásquez Restrepo, Holly M. Garrod, Jacob C. Cooper

Neotropical Biodiversity

No abstract provided.

Missing The Boat: Black Americans And The Struggle To Stay Afloat In A Nineteenth Century Ocean Of Ideas, Jodie Salazar

Research Papers

This paper explores the effects of various social movements on Black Americans in the nineteenth century. This examination is used as an historical background of a larger Reacting to the Past pedagogical game design set in Chicago at the time of the World's Columbian Exposition. The focus of this work explores ideological views on colonization, immigration, and citizenship, as well as the various laws and viewpoints which worked to oppress Black Americans after Emancipation.

Reviving The Roots: A Qualitative Phenomenological Study Of Black Women In Agriculture And The Influence Of Post-Secondary Education, Alvianna Woodard-Davis

Doctoral Dissertations and Projects

The purpose of this qualitative phenomenological study was to explore the perceptions and lived experiences of twenty Black women in the southern United States and the influence of post-secondary education on agricultural science. Two theories guided this study, Maslow's hierarchy of needs and Crenshaw’s intersectionality theory. When considering the five levels of Maslow's hierarchy, coupled with Black women's marginality as identified by the intersectionality theory, the research helped better define the relationship between Black women in agriculture and the referenced theories. Criterion sampling was used to identify ten experienced Black female producers and ten agriculture students to determine the trend. …

Grounded Theory Study On The Perceived Relationship Between Classical Leadership Theories Education And Christian Ministry Leader's Success, Yannique Thomas

Doctoral Dissertations and Projects

A central aim of the research study was for colleges and universities that prepare Christian ministry leaders for ministry in the twenty-first century to include classical leadership theories education in order to meet the growing demand for equipping Christian ministry leaders of the future for success (Kessler & Kretszchmar, 2015). The research findings overwhelmingly suggested that there is a direct link between classical leadership theories education and Christian ministry leaders’ success. All of the characteristics, skills, talents, and attributes identified through receiving classical leadership theories education shifts the emphasis away from what the Christian ministry leader knows in his head …

Research Discussion With Philip Kavouriaris, Caroline Winnenberg, Philip Kavouriaris

Steeplechase: An ORCA Student Journal

Chief Editor Caroline Winnenberg conducted an interview with Philip Kavouriaris on November 30th, 2022 in Waterfield Library at 3:00 pm. Kavouriaris discusses his passion for ornithology and the experience of working on a large-scale field study.

Issue 415: April 6-20, 2023, The Local Voice

The Local Voice

No abstract provided.

A Quieter Ocean: Experimentally Derived Differences In Attentive Responses Of Tursiops Truncatus To Anthropogenic Noise Playbacks Before And During The Covid-19-Related Anthropause, Paige E. Stevens, Veda Allen, Jason N. Bruck

Faculty Publications

The effects of anthropogenic noise continue to threaten marine fauna, yet the impacts of human-produced sound on the broad aspects of cognition in marine mammals remain relatively understudied. The shutdown of non-essential activities due to the COVID-19-related anthropause created an opportunity to determine if reducing levels of oceanic anthropogenic noise on cetaceans affected processes of sensitization and habituation for common human-made sounds in an experimental setting. Dolphins at Dolphin Quest Bermuda were presented with three noises related to human activities (cruise ship, personal watercraft, and Navy low-frequency active sonar) both in 2018 and again during the anthropause in 2021 via …

Disruptive Lysosomal-Metabolic Signaling And Neurodevelopmental Deficits That Precede Purkinje Cell Loss In A Mouse Model Of Niemann-Pick Type-C Disease., Sarah Kim, Kathleen Ochoa, Sierra E Melli, Fawad A K Yousufzai, Zerian D Barrera, Aela A Williams, Gianna Mcintyre, Esteban Delgado, James N Bolish, Collin M Macleod, Mary Boghos, Hayden P Lens, Alex G Ramos, Vincent B Wilson, Kelly Maloney, Zachary M Padron, Amaal H Khan, Rosa E Blanco, Ileana Soto

College of Science & Mathematics Departmental Research

Purkinje cell (PC) loss occurs at an early age in patients and animal models of Niemann-Pick Type C (NPC), a lysosomal storage disease caused by mutations in the Npc1 or Npc2 genes. Although degeneration of PCs occurs early in NPC, little is known about how NPC1 deficiency affects the postnatal development of PCs. Using the Npc1nmf164 mouse model, we found that NPC1 deficiency significantly affected the postnatal development of PC dendrites and synapses. The developing dendrites of Npc1nmf164 PCs were significantly deficient in mitochondria and lysosomes. Furthermore, anabolic (mTORC1) and catabolic (TFEB) signaling pathways were not only perturbed …

The Indiana Statesman, April 6, 2023, Indiana State University

Student Newspaper

Indiana State University radio wins national award; How ISU can help you with upcoming finals; Maryland releases report on clergy abuse; Victims in Texas church shooting reach $144m settlement

The Power Of Citizen Science: Overcoming The Knowledge Gap Of The Marine Mammal Diversity In The Bay Islands Of Honduras, Gloria Joo Ryung Oh

Honors Theses

Preservation of regional biological diversity requires an understanding of the inhabiting species. However, species surveys are often difficult due to a a lack of resources.  This study utilized citizen science, which involves the use of non-scientists for data collection, to summarize the marine mammal sightings  in the Bay Islands of Honduras (BIH). After data filtration, thirteen species of marine mammals were identified in the 509 observations records, of which 92% originated from citizen science sources.  These included four species that did not have a previous record in the BIH, two of which were first reports for the country of Honduras: …

A Projectile Concussive Impact Model Produces Neuroinflammation In Both Mild And Moderate-Severe Traumatic Brain Injury., Lindsay T Michalovicz, Kimberly A Kelly, Travis J. A. Craddock, James P O'Callaghan

HPD Articles

Traumatic brain injury (TBI) is a major cause of death and disability and is experienced by nearly 3 million people annually as a result of falls, vehicular accidents, or from being struck by or against an object. While TBIs can range in severity, the majority of injuries are considered to be mild. However, TBI of any severity has the potential to have long-lasting neurological effects, including headaches, cognitive/memory impairments, mood dysfunction, and fatigue as a result of neural damage and neuroinflammation. Here, we modified a projectile concussive impact (PCI) model of TBI to deliver a closed-head impact with variable severity …

Spartan Daily, April 6, 2023, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2023

Volume 160, Issue 28

The Comment, April 6, 2023, Bridgewater State University

The Comment

No abstract provided.

Effect Of Padina Minor Powder Extract As Biostimulant And Black Soldier Fly Fertilizer On Growth And Yield Of Soybean (Glycine Max L. Merrill), Zozy Aneloi Noli, Suwirmen, Julita

Jurnal Kultivasi

Soybean production has not met domestic demand, causing dependence on imported soybeans. Increasing soybean production can be done by giving organic materials such as fertilizer and biostimulants. Applying Padina minor extract as a biostimulant and black soldier fly (BSF) fertilizer can be an alternative to increase the growth and production of soybean. The research aims to determine the effect of Padina minor powder extract, BSF fertilizer, and the combination of Padina minor powder extract and BSF fertilizer on the growth and yield of soybean. This research was carried out from April to July 2021 at the Plant Physiology Laboratory and …