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Embodied, Simulation-Based Cognition: A Hybrid Approach, Sean Christopher Kugele

Electronic Theses and Dissertations Archive

Embodied cognition is a paradigm in cognitive science that emphasizes the fundamental role of bodies, environmental interactions, situational contexts, and sensory and motor systems in cognitive processing. Much of the research in embodied cognition has focused on online cognitive activities (such as reactive, overt behaviors) that are directly coupled to environmental stimuli. Such research fails to explain offline cognitive activities (such as planning, deliberation, and mental imagery) that are spatially or temporally decoupled from one’s immediate sensory experiences. Embodied, simulation-based theories of cognition attempt to address this shortcoming by proposing a mechanism—modal simulations—by which sensory and motor systems can directly …

Spike-Phase Coupling Patterns Reveal Laminar Identity In Primate Cortex, Zachary W Davis, Nicholas M Dotson, Tom P Franken, Lyle Muller, John H Reynolds

2020-Current year OA Pubs

The cortical column is one of the fundamental computational circuits in the brain. In order to understand the role neurons in different layers of this circuit play in cortical function it is necessary to identify the boundaries that separate the laminar compartments. While histological approaches can reveal ground truth they are not a practical means of identifying cortical layers in vivo. The gold standard for identifying laminar compartments in electrophysiological recordings is current-source density (CSD) analysis. However, laminar CSD analysis requires averaging across reliably evoked responses that target the input layer in cortex, which may be difficult to generate in …

Fatty Acid, Carotenoid And Fat-Soluble Vitamin Composition Of Multispecies Swards Grown In Ireland—Implications For A Sustainable Feed In Dairy Farming, Samuel Rapisarda, Graham O'Neill, Nissreen Abu-Ghannam

Articles

Although traditional ryegrass pastures are still commonly used, they require intense management and input and do not perform well during the summer months. Multispecies systems have been recognised as more sustainable, needing less fertiliser and being tolerant to drought and heat. While data on monoculture system fat composition exist, information for multispecies is scarce. The present study compared the fatty acid (FA), carotenoid and fat-soluble composition of a multispecies system (consisting of perennial ryegrass, timothy, white clover, red clover, chicory and plantain) (MULTI) with two other conventional grazing systems (monoculture perennial ryegrass (PRG) and a binary mixture of perennial ryegrass …

Structure Of Anhydrotetracycline-Bound Tet(X6) Reveals The Mechanism For Inhibition Of Type 1 Tetracycline Destructases, Hirdesh Kumar, Emily E Williford, Kevin S Blake, Brett Virgin-Downey, Gautam Dantas, Timothy A Wencewicz, Niraj H Tolia

2020-Current year OA Pubs

Inactivation of tetracycline antibiotics by tetracycline destructases (TDases) remains a clinical and agricultural threat. TDases can be classified as type 1 Tet(X)-like TDases and type 2 soil-derived TDases. Type 1 TDases are widely identified in clinical pathogens. A combination therapy of tetracycline and a TDase inhibitor is much needed to rescue the clinical efficacy of tetracyclines. Anhydrotetracycline is a pan-TDase inhibitor that inhibits both type 1 and type 2 TDases. Here, we present structural, biochemical, and phenotypic evidence that anhydrotetracycline binds in a substrate-like orientation and competitively inhibits the type 1 TDase Tet(X6) to rescue tetracycline antibiotic activity as a …

A Pilot Investigation Of Differential Hydroxymethylation Levels In Patient-Derived Neural Stem Cells Implicates Altered Cortical Development In Bipolar Disorder, Ashish Kumar, Mark Z. Kos, Donna Roybal, Melanie A. Carless

School of Medicine Publications

Introduction: Bipolar disorder (BD) is a chronic mental illness characterized by recurrent episodes of mania and depression and associated with social and cognitive disturbances. Environmental factors, such as maternal smoking and childhood trauma, are believed to modulate risk genotypes and contribute to the pathogenesis of BD, suggesting a key role in epigenetic regulation during neurodevelopment. 5-hydroxymethylcytosine (5hmC) is an epigenetic variant of particular interest, as it is highly expressed in the brain and is implicated in neurodevelopment, and psychiatric and neurological disorders.

Methods: Induced pluripotent stem cells (iPSCs) were generated from the white blood cells of two adolescent patients with …

Hepatocyte Srebp Signaling Mediates Clock Communication Within The Liver, Dongyin Guan, Hosung Bae, Dishu Zhou, Ying Chen, Chunjie Jiang, Cam Mong La, Yang Xiao, Kun Zhu, Wenxiang Hu, Trang Minh Trinh, Panpan Liu, Ying Xiong, Bishuang Cai, Cholsoon Jang, Mitchell A Lazar

Faculty, Staff and Students Publications

Rhythmic intraorgan communication coordinates environmental signals and the cell-intrinsic clock to maintain organ homeostasis. Hepatocyte-specific KO of core components of the molecular clock Rev-erbα and -β (Reverb-hDKO) alters cholesterol and lipid metabolism in hepatocytes as well as rhythmic gene expression in nonparenchymal cells (NPCs) of the liver. Here, we report that in fatty liver caused by diet-induced obesity (DIO), hepatocyte SREBP cleavage-activating protein (SCAP) was required for Reverb-hDKO-induced diurnal rhythmic remodeling and epigenomic reprogramming in liver macrophages (LMs). Integrative analyses of isolated hepatocytes and LMs revealed that SCAP-dependent lipidomic changes in REV-ERB-depleted hepatocytes led to the enhancement of LM metabolic …

The Hero’S Journey As A Novel, Narrative, And Improvisational Group Intervention On Quality Of Life For People With Parkinson’S Disease, Robert D. Cochrane, James W. Navalta, Anne E. Weisman

Heroism Science

Parkinson’s disease (PD) is one of the fastest-growing neurological diseases in the world. Pharmaceutical and surgical interventions continue to advance to better address motor symptoms. However, disability from non-motor symptoms, such as depression, anxiety, and stress persist. Expressive therapies, including art, music, and dance are being explored and implemented more frequently to address this growing need. We developed this study to examine the feasibility of a novel program using online narrative therapy, with constructs from Joseph Campbell’s Hero’s Journey, and improvisation for people with PD (PWPD). Participants from across the U.S. and U.K. met online via Zoom once a week …

Annual Faculty Research Symposium 2023, Oakwood University

Proceedings

No abstract provided.

Biden, Bennet, And Bipartisan Federal Judicial Selection, Carl Tobias

University of Colorado Law Review Forum

No abstract provided.

How Resilience Is Framed Matters For Governance Of Coastal Social-Ecological Systems, Sarah Clement, Javad Jozaei, Michael Mitchell, Craig R. Allen, Ahjond S. Garmestani

School of Natural Resources: Faculty Publications

Effective governance of social-ecological systems (SES) is an enduring challenge, especially in coastal environments where accelerating impacts of climate change are increasing pressure on already stressed systems. While resilience is often proposed as a suitable framing to re-orient governance and management, the literature includes many different, and sometimes conflicting, definitions and ideas that influence how the concept is applied, especially in coastal environments. This study combines discourse analysis of the coastal governance literature and key informant interviews in Tasmania, Australia, demonstrating inconsistencies and confusion in the way that resilience is framed in coastal governance research and practice. We find that …

The Socialization Of Willie B. - Part 2, Terry Maple

Tales of WellBeing

This tale is the second in a three-part series about Willie B., Atlanta’s iconic ape and one of the most famous gorillas in the world.

The Characterization Of Selected Α- And Β-Carbonic Anhydrases Of Arabidopsis Thaliana, Hiruni Weerasooriya

LSU Doctoral Dissertations

Carbonic anhydrases (CAs) are zinc-metalloenzymes that interconvert two inorganic carbon (Ci) species, CO₂ and HCO₃^-. In Arabidopsis thaliana, there are eight αCA genes, six βCA genes, three γCA genes, and two γCA-like genes. The majority of CA research in plants has focused on finding a link between CA activity and photosynthesis rates. Since the CA genes are expressed in different plant tissues and multiple CA isoforms are distributed among various organelles of the plant cell, I hypothesize that CAs facilitate CO₂ diffusion among cell compartments and maintain Ci pools for carbon-requiring reactions by interconverting …

From Animal To Plant Sentience: Is There Credible Evidence?, Leonard Dung

Animal Sentience

Segundo-Ortin & Calvo argue that plants have a surprisingly varied and complex behavioral repertoire. Which of these behavioral capacities are credible indicators of sentience? If we use the standards of evidence common in discussions of animal sentience, the behavioral capacities reviewed are insufficient evidence of sentience. Even if some putative indicators of animal sentience are present in plants, it is not clear whether what we should conclude is that plants are sentient or that those indicators are inadequate.

Women's Chorale [And] Schola Cantorum, Department Of Music, University Of Richmond

Music Department Concert Programs

No abstract provided.

Investigating Iraqi Efl University Students' Use Of Key Morphological Terms, Yousuf Taresh Hilal Jabur Al Amaya, Elhaj Ali Adam Esmaeil

Uruk Journal of Human Sciences

The current study investigates the Iraqi college learners' abilities to handle morphological terms as a main part of EFL learners' grammatical competence. In this study, morphological terms are classified into two types: General Morphological Terms and Word-Formation Terms. It is worth mentioning that this study is restricted to the morphological terms that are of concern to the EFL university students because such terms represent rather important part of grammar, than minor concepts and details. After surveying such terms, the researcher devised a questionnaire prepared for a representative sample of (100) Iraqi EFL college students randomly chosen from the 3rd year …

"Azat, Ankakh, Artsakh": Music, Memory, And The Second Nagorno-Karabakh War, Sasha Linn Arteaga

Music ETDs

In this thesis, I examine a selection of music videos, from those created in 2015 at the centenary of the Armenian Genocide, to those created in response to the Second Nagorno-Karabakh War, considered by Armenians to be a continuation of the Armenian Genocide. To the Armenian people, Nagorno-Karabakh is part of their ethnic homeland and has maintained a majority-Armenian population and separatist government backed by the Republic of Armenia since the First Nagorno-Karabakh War. I apply a music-as-text approach in this thesis, examining these music videos through examination of the visual, musical, and lyrical elements. I then analyze these videos …

Higher Education Teaching Platforms With Research, Node-Based Visual Effects And Animation, Erika Grodzki, Daniel Coes, Hung Chum Kao

Faculty and Staff Publications & Presentations

This panel will discuss the current industry technology that can apply to higher education. From the history of Animation, Motion Graphic, and node base Animation and visual effect fields. Through this presentation and peers' discussions, we should have a strong understanding of how to adapt to advanced technology and reshape higher education with Modern Technology topics. Moderator: Erika Grodzki, Lynn University Panelists: Erika Grodzki, Lynn University Daniel Coes, Lynn University Kevin Kao, Lynn University

Initiating And Imaging Cavitation From Infused Echo Contrast Agents Through The Ekosonic Catheter, Sonya R Kennedy, Maxime Lafond, Kevin J Haworth, Daniel Suarez Escudero, Dan Ionascu, Brion Frierson, Shaoling Huang, Melvin E Klegerman, Tao Peng, David D Mcpherson, Curtis Genstler, Christy K Holland

Faculty, Staff and Student Publications

Ultrasound-enhanced delivery of therapeutic-loaded echogenic liposomes is under development for vascular applications using the EkoSonic Endovascular System. In this study, fibrin-targeted echogenic liposomes loaded with an anti-inflammatory agent were characterized before and after infusion through an EkoSonic catheter. Cavitation activity was nucleated by Definity or fibrin-targeted, drug-loaded echogenic liposomes infused and insonified with EkoSonic catheters. Passive cavitation imaging was used to quantify and map bubble activity in a flow phantom mimicking porcine arterial flow. Cavitation was sustained during 3-min infusions of Definity or echogenic liposomes along the distal 6 cm treatment zone of the catheter. Though the EkoSonic catheter was …

Voter Due Process And The "Independent" State Legislature, Michael P. Bellis

Northwestern University Law Review

In a series of opinions surrounding the 2020 presidential election, multiple U.S. Supreme Court Justices broke from precedent to signal support of the “independent state legislature theory” (ISLT), a formerly obscure interpretation of state legislatures’ power over the administration of federal elections. Proponents of the ISLT allege that the U.S. Constitution grants state legislatures plenary power in federal election contexts—including the power to discount ballots, redraw legislative maps, or appoint alternative slates of presidential electors. Although the Court denied certiorari in each case, across the denials four current Justices dissented because they considered the ISLT to be a proper interpretation …

Effects Of Curricular Integration Of Students’ Identities, Reanne B. Rivera, Leah A. Nillas, Faculty Advisor

John Wesley Powell Student Research Conference

The curricular integration of students’ cultural identities is a critical component of maximizing students’ learning as educators bridge their students’ lived experiences and cultural backgrounds to their learning (Ladson-Billings, 1995). Another component of students’ identities entails their learning styles. When students’ preferred learning styles are implemented into the classroom they showed higher levels of academic achievement and engagement (Lauria, 2010). A final component of students’ identities explored in this classroom research includes students’ interests. Engagement is learning when students’ choices and interests are considered for their learning (Beecher & Sweeney, 2008). The significance of this research project is to analyze …

“Why You Always So Political?”: A Counterstory About Educational-Environmental Racism At A Predominantly White University, Martín Alberto Gonzalez

Taboo: The Journal of Culture and Education

Using critical race counterstorytelling, I tell a story about the experiences of Mexican/Mexican American/Xicanx (MMAX) undergraduate students at private, historically and predominantly white university in the Northeast. Drawing on in-depth interviews, participant observations, pláticas, document analyses, and literature on race and space and racism in higher education, I argue that the racially hostile campus environment experienced by MMAX students at their respective university manifests itself as a form of educational-environmental racism. Through narrated dialogue, Aurora (a composite character) and I delve into a critical conversation about how educational-environmental racism is experienced by MMAX students through a racialized landscape in the …

When Diversity Isn't The Point: Mirrors, Windows, And Sliding Glass Doors In The Classroom, Kaitlin M. Jackson

Taboo: The Journal of Culture and Education

This article seeks to provide tangible action steps for both preservice and current teachers toward cultural competence through the intentional use of diverse and inclusive children's literature. The article describes the implications of representation of various identities and the intersection of those identities in textbooks for children belonging to all marginalized identities as well as those in groups aligning with societal defaults, including race, culture, language, religion, gender, sexual orientation, and disability.

Occupational Therapists' Perspectives On Nursing Home Culture And Addressing The Psychosocial Needs Of Residents: Mixed Methods Design, Nayeli Mendoza, Mikayla C. Wandersee, Divya Sood

The Open Journal of Occupational Therapy

Background: The purpose of this study was to explore occupational therapists’ perspectives on the culture change movement to address the psychosocial components of care among nursing home residents and identify supports and barriers to implementing the culture change movement.

Methods: We used a sequential explanatory mixed methods design. Electronic surveys were completed by 102 occupational therapists who work in nursing home facilities. Three focus groups were conducted via conference call with occupational therapists (n = 9). The survey was analyzed using descriptive statistics and content analysis. Focus groups were analyzed using thematic analysis.

Results: Seventy-four of survey …

Shared Concepts Guiding The Practice Of A Community Occupational Therapy Program Serving Youth With Psychosocial Challenges, Chi-Kwan Shea, Nancy Jackson, Marianna Ayers Sordille

The Open Journal of Occupational Therapy

Background: Occupational therapy services to youth with trauma experiences and mental health challenges may follow unique practice concepts that deserve to be explored and illuminated. The study aimed to explore and identify shared concepts that have been guiding the occupational therapy practice of a community-based program serving the youth population.

Method: The qualitative study analyzed data from transcripts of one-on-one interviews with occupational therapists who serve youth clients in the community-based program. Using a grounded theory qualitative approach, the analysis aimed to highlight unique concepts that the occupational therapists employed in their day-to-day practice with youth who experience …

Pten Inhibition Dedifferentiates Long-Distance Axon-Regenerating Intrinsically Photosensitive Retinal Ganglion Cells And Upregulates Mitochondria-Associated Dynlt1a And Lars2., Bruce A Rheaume, Jian Xing, Agnieszka Lukomska, William C Theune, Ashiti Damania, Greg Sjogren, Ephraim F Trakhtenberg

Faculty Research 2023

Central nervous system projection neurons fail to spontaneously regenerate injured axons. Targeting developmentally regulated genes in order to reactivate embryonic intrinsic axon growth capacity or targeting pro-growth tumor suppressor genes such as Pten promotes long-distance axon regeneration in only a small subset of injured retinal ganglion cells (RGCs), despite many RGCs regenerating short-distance axons. A recent study identified αRGCs as the primary type that regenerates short-distance axons in response to Pten inhibition, but the rare types which regenerate long-distance axons, and cellular features that enable such response, remained unknown. Here, we used a new method for capturing specifically the rare …

Irrigation Zone Delineation And Management With A Field-Scale Variable Rate Irrigation System In Winter Wheat, Elisa A. Flint, Bryan G. Hopkins, Jeffery D. Svedin, Ruth Kerry, Matthew J. Heaton, Ryan R. Jensen, Colin S. Campbell, Matt Yost, Neil C. Hansen

Plants, Soils, and Climate Faculty Publications

Understanding spatial and temporal dynamics of soil water within fields is critical for effective variable rate irrigation (VRI) management. The objectives of this study were to develop VRI zones, manage irrigation rates within VRI zones, and examine temporal differences in soil volumetric water content (VWC) from irrigation events via soil sensors across zones. Five irrigation zones were delineated after two years (2016 and 2017) of yield and evapotranspiration (ET) data collection. Soil sensors were placed within each zone to give real time data of VWC values and assist in irrigation decisions within a 23 ha field of winter wheat ( …

Identification Of A Heterogeneous And Dynamic Ciliome During Embryonic Development And Cell Differentiation., Kelsey H Elliott, Sai K Balchand, Christian Louis Bonatto Paese, Ching-Fang Chang, Yanfen Yang, Kari M Brown, Daniel T Rasicci, Hao He, Konrad Thorner, Praneet Chaturvedi, Stephen A Murray, Jing Chen, Aleksey Porollo, Kevin A Peterson, Samantha A Brugmann

Faculty Research 2023

Primary cilia are nearly ubiquitous organelles that transduce molecular and mechanical signals. Although the basic structure of the cilium and the cadre of genes that contribute to ciliary formation and function (the ciliome) are believed to be evolutionarily conserved, the presentation of ciliopathies with narrow, tissue-specific phenotypes and distinct molecular readouts suggests that an unappreciated heterogeneity exists within this organelle. Here, we provide a searchable transcriptomic resource for a curated primary ciliome, detailing various subgroups of differentially expressed genes within the ciliome that display tissue and temporal specificity. Genes within the differentially expressed ciliome exhibited a lower level of functional …

Ecological Impacts Of Invasive Crayfish In A Naïve Riparian System, Gregor L. Hamilton

Biology ETDs

Aquatic and riparian food webs are inextricably linked. In deserts, they provide critical energy subsidies to surrounding terrestrial food webs, but these vital subsidies are not guaranteed; streams in arid lands are especially sensitive to perturbations. In this dissertation, I investigated the role of an oft-cited threat to stream communities in the lower Colorado River basin: non-native crayfish. I contributed to methodologies in passive integrated transponder use and length-weight relationships in crayfish to aid future research. I leveraged stable isotope analysis of δ¹⁵N, δ¹³C, and δ²H to understand crayfish role in the food webs. …

Significant Montana Cases, Moriah Williams, Zachary Stauffer

Montana Law Review

No abstract provided.

A Unique Check On Government Power: Reconceptualizing The Right To Know As A Democracy-Promoting Provision, Constance Van Kley

Montana Law Review

No abstract provided.