Digital Commons Network^™

Combining Community Observations And Remote Sensing To Examine The Effects Of Roads On Wildfires In The East Siberian Boreal Forest, Vera Kuklina, Oleg Sizov, Victor Bogdanov, Natalia Krasnoshtanova, Arina Morozova, Andrey N. Petrov

Faculty Publications

The paper is aimed at assessing the associations between the road networks geography and dynamics of wildfire events in the East Siberian boreal forest. We examined the relationship between the function of roads, their use, and management and the wildfire ignition, propagation, and termination during the catastrophic fire season of 2016 in the Irkutsk Region of Russia. Document analysis and interviews were utilized to identify main forest users and road infrastructure functional types and examine wildfire management practices. We combined community observations and satellite remotely sensed data to assess relationships between the location, extent, and timing of wildfires and different …

Long-Term Mammal Herbivory On Arthropod Assemblages At Kruger National Park, South Africa, Ludzula Mukwevho, Tatenda Dalu, Frank Chidawanyika

All Peer-Reviewed Publications

Protected savannas are essential reserves for biological diversity, including endangered arthropod species, however, extreme grazing by mammals has cascading impacts on the communities and disrupts the functioning of these ecosystems globally. The current study assessed the abundance, species richness and composition of arthropods at the long-term grazing exclosures of Kruger National Park, South Africa. Pitfall traps and active searches were used to sample arthropods at the ungrazed, moderately, and heavily grazed exclosures. We found that Hymenoptera, Coleoptera, Diptera and Araneae were the most abundant orders of arthropods sampled. The abundance of multi-taxon, Diptera and Hymenoptera was significantly different between exclosures. …

Effect Of Use Of Tsetse Repellant Collar Technology On The Farm Performance And Household Welfare Of Small-Scale Livestock Farmers In Kenya, Beatrice W. Muriithi, Kassie Menale, Gracious M. Diiro, Michael N. Okal, Daniel K. Masiga

All Peer-Reviewed Publications

Tsetse-transmitted Animal African Trypanosomosis (AAT) is a disease of economic importance to livestock development in Sub-Saharan Africa. The disease is widely managed using trypanocides that are expensive for smallholders and associated with health risks due to drug residues in animal products and drug resistance. Developed recently by the International Centre of Insect Physiology and Ecology (icipe) and partners, the novel Tsetse repellent collar technology (TRCT) provides an effective alternative control measure that targets the tsetse fly vector of AAT. This study assessed the impact of TRCT on household welfare and food security by using ex-post non-experimental data obtained from 632 …

Proper Purposes And Directors' Duties: Time To Slay The Chimera?, Pearlie M. C. Koh

Research Collection Yong Pung How School Of Law

The statutory statement of directors' duties contained in the Companies Act 2006 imposes a duty on directors to ‘only exercise powers for the purposes for which they are conferred’. The duty has been equiparated with the equitable fraud on a power doctrine. This paper challenges the correctness of this approach, and argues that the unwarranted ‘merging’ of the duty and the doctrine has resulted in a legal chimera standing in the way of a proper understanding of the roles of each of the duty and the doctrine. It is submitted that this erroneous linking of two entirely different concepts is …

Peripheral And Central Impact Of Methionine Source And Level On Growth Performance, Circulating Methionine Levels And Metabolism In Broiler Chickens, Craig W. Maynard, Elizabeth Gilbert, Frances Yan, Mark A. Cline, Sami Dridi

Poultry Science Faculty Publications and Presentations

The present study was designed to evaluate the effects of DL-methionine (DL-Met) 2-hydroxy-4-(methylthio) butanoic acid (HMTBa), or S-(5′-Adenosyl)-L-methionine chloride (SAM), using feeding trial and central administration, on live performance, plasma metabolites, and the expression of feeding-related hypothalamic neuropeptides in broilers raised to a market age (35 d). Final average body weight (BW) and feed conversion ratio (FCR) from the feeding trial exceeded the performance measurements published by the primary breeder. At d35, the MTBHa group had better BW and lower feed intake, which resulted in a better FCR than the DL-Met group at 87 TSAA to lysine. At the molecular …

Impact Of Phytase Supplementation On Meat Quality Of Heat-Stressed Broilers, C. J. Maynard, C. W. Maynard, Garrett J. Mullenix, Alison Ramser, Elizabeth S. Greene, Mike R. Bedford, Sami Dridi

Poultry Science Faculty Publications and Presentations

Heat stress (HS) is one of the most challenging stressors to poultry production sustainability. The adverse effects of HS range from feed intake and growth depression to alteration of meat quality and safety. As phytase supplementation is known to improve nutrient utilization and consequently growth, we undertook the present study to evaluate the effects of dietary phytase on growth and meat quality in heat-stressed broilers. A total of 720 day-old hatch Cobb 500 chicks were assigned to 24 pens within controlled environmental chambers and fed three diets: Negative Control (NC), Positive Control (PC), and NC diet supplemented with 2000 phytase …

Impact Of Eimeria Meleagrimitis And Intermittent Amprolium Treatment On Performance And The Gut Microbiome Composition Of Turkey Poults, Carolina Trujillo-Peralta, Juan David Latorre, Jianmin Chai, Roberto Señas-Cuesta, Aaron Forga, Makenly Coles, Jiangchao Zhao, Xochitl Hernandez-Velasco, Guillermo Tellez-Isaias, John R. Barta, Lisa Bielke, Billy Hargis, Danielle Graham

Poultry Science Faculty Publications and Presentations

Introduction: Drug-sensitive live coccidiosis vaccines have been used to control coccidiosis and renew drug sensitivity in commercial chicken operations. However, only limited species coverage vaccines have been available for commercial turkey producers. This study aimed to assess the effect of an E. meleagrimitis vaccine candidate, with and without amprolium intervention, on performance and oocyst shedding. Additionally, the effect of vaccination, amprolium treatment, and E. meleagrimitis challenge on intestinal integrity and microbiome composition was evaluated.

Methods: Experimental groups included: (1) NC (non-vaccinated, non-challenged control); (2) PC (non-vaccinated, challenged control); (3) VX + Amprol (E. meleagrimitis candidate vaccine + amprolium); and …

Umm Huwaiwitat: A Neolithic Site Near Petra, Jordan, Daniel Plekhov, Cristiano Nicosia, Luiza Osorio G. Silva, Sarah Newman, Felipe Rojas

Anthropology Faculty Publications and Presentations

Studies of the rural landscapes around the Nabataean/Roman city of Petra in Jordan have tended to assume a developmental trajectory based on that of the urban centre. Recent archaeological investigations at the site of Umm Huwaiwitat, however, shed light on the longer-term histories of human occupation and land use in the region north of Petra. Excavation has revealed Late Neolithic deposits formed by the burning of animal dung and the disposal of ash. These deposits underlie walls, today serving as agricultural terraces, which date to at least the Early Bronze Age. Umm Huwaiwitat therefore provides a microcosm of the long-lived …

Flash-Rt: Using High-Dose Radiation For Clinical Radiation Therapy, Deja Stubbs

University Honors Theses

This paper is a literature review on the possible mechanisms behind the FLASH effect and why such research can advance the world of radiology treatment by modifying current clinical linear accelerators to produce ultra-high doses of radiation. Radiation Therapy, also known as external Beam Radiation Therapy, is a common type of cancer treatment. Globally, cancer is the second-leading cause of death, but has seen an increase in survival rates over the past couple of years. Cancer can develop in almost any part of the body since cancer is defined as uncontrolled cell growth. The FLASH Effect is seen when treating …

Examining Benefits Of Early Intervention In Cases Of Pediatric Chronic Hypoxia, Kendra Stefan

University Honors Theses

There is a strong foundation of evidence and consensus in the literature that hypoxia has adverse impacts on brain function. Recent research has broadened the field in two directions. One is the treatment for acute hypoxic injuries, and the second is regarding the accumulative impact of intermittent or chronic hypoxia. Historically, in cases of acute hypoxia, action is taken to remedy the source of hypoxia. Physical and cognitive rehabilitation has typically been provided as needed depending on the severity of the injury. While cases of intermittent or chronic hypoxia may not demonstrate an acute urgency for treatment and rehabilitation, current …

Indigenous Water Justice: Theory, Gaps, And Opportunities For Application, Ruby Howard

University Honors Theses

Indigenous people are particularly at risk of water scarcity in the U.S. and abroad, and face high rates of nonexistent or failing water infrastructure, water pollution, pipeline proposals that threaten water resources, and water-related climate change impacts. They also are often unequipped, politically and economically, to react and adapt to these impacts, resulting in devastating health impacts. Due to this widespread insecurity, many scholars are calling for the application of a theory and set of principles known as water justice. However, Indigenous people have pointed out that water justice literature does not focus enough on Indigenous issues, often neglecting the …

Lights, Camera, Climate Action: Investigating Emotional Responses To Climate Change Trailers (Documentary, Television, & Narrative Film), Erik Daniel Schell Devore

University Honors Theses

This research examined the emotional responses elicited by different genres of environmental visual media (VM) trailers. Six undergraduate Environmental Science and Management student participants self-selected to watch trailers from three different genres of VM: a documentary film, a television series, and a narrative film. The goal of this research was to understand the extent people become aware of various environmental VM topics, how VM elicits emotional responses, the effectiveness of VM in promoting action, and to gain a better understanding of how producers and directors can potentially modify VM to have a greater impact on changing participants' attitudes toward climate …

The Sanitary Lens: A Study Of 19th Century Public Health In British Colonial India And Australia, Josephine Cannistra

University Honors Theses

Specific colonial processes informed highly distinct policies of public health and sanitation in colonial India and Australia. Their distinctions and lasting legacies are obscured when they are uncritically lumped together within the British Empire. The 19th century was a period of great change throughout India and Australia. It was also a period of dramatic change in general understandings of sanitation and health. This paper examines colonial India and Australia through the lens of sanitation and medicine as it was understood and practiced in British spheres of influence. A comparative approach to these histories and this past sheds light on how …

Investigating The Mammillary Bodies As An Early Target Of Alzheimer's Disease, Cole Martinson

University Honors Theses

Alzheimer's disease (AD) is the most common form of dementia. With minimal treatment options and no cure, developing a deeper understanding of the pathology of the disease is crucial. For nearly four decades, the accumulation of beta-amyloid (Aβ) plaques has been correlated with the disease and its progression. Previous studies mapping this accumulation show that the mammillary bodies (MB) are an early target of the disease. Glutamatergic neurons are of key interest due to their prevalence in the central nervous system, specifically the MB. To understand the effects of AD on the glutamatergic system, we used vesicular glutamate transporter 2 …

Clinical Spectrum And Genetic Causes Of Mitochondrial Hepatopathy Phenotype In Children, James E Squires, Alexander G Miethke, C Alexander Valencia, Kieran Hawthorne, Lisa Henn, Johan L K Van Hove, Robert H Squires, Kevin Bove, Simon Horslen, Rohit Kohli, Jean P Molleston, Rene Romero, Estella M Alonso, Jorge A Bezerra, Stephen L Guthery, Evelyn Hsu, Saul J Karpen, Kathleen M Loomes, Vicky L Ng, Philip Rosenthal, Krupa Mysore, Kasper S Wang, Marisa W Friederich, John C Magee, Ronald J Sokol, Childhood Liver Disease Research Network (Children)

Faculty, Staff and Students Publications

BACKGROUND: Alterations in both mitochondrial DNA (mtDNA) and nuclear DNA genes affect mitochondria function, causing a range of liver-based conditions termed mitochondrial hepatopathies (MH), which are subcategorized as mtDNA depletion, RNA translation, mtDNA deletion, and enzymatic disorders. We aim to enhance the understanding of pathogenesis and natural history of MH.

METHODS: We analyzed data from patients with MH phenotypes to identify genetic causes, characterize the spectrum of clinical presentation, and determine outcomes.

RESULTS: Three enrollment phenotypes, that is, acute liver failure (ALF, n = 37), chronic liver disease (Chronic, n = 40), and post-liver transplant (n = 9), were analyzed. …

Preterm Birth Alters The Feeding-Induced Activation Of Akt Signaling In The Muscle Of Neonatal Piglets, Agus Suryawan, Marko Rudar, Jane K Naberhuis, Marta L Fiorotto, Teresa A Davis

Faculty, Staff and Students Publications

BACKGROUND: Postnatal lean mass accretion is commonly reduced in preterm infants. This study investigated mechanisms involved in the blunted feeding-induced activation of Akt in the skeletal muscle of preterm pigs that contributes to lower protein synthesis rates.

METHODS: On day 3 following cesarean section, preterm and term piglets were fasted or fed an enteral meal. Activation of Akt signaling pathways in skeletal muscle was determined.

RESULTS: Akt1 and Akt2, but not Akt3, phosphorylation were lower in the skeletal muscle of preterm than in term pigs (P < 0.05). Activation of Akt-positive regulators, PDK1 and mTORC2, but not FAK, were lower in preterm than in term (P < 0.05). The formation of Akt complexes with GAPDH and Hsp90 and the abundance of Ubl4A were lower in preterm than in term (P < 0.05). The abundance of Akt inhibitors, PHLPP and SHIP2, but not PTEN and IP6K1, were higher in preterm than in term pigs (P < 0.05). PP2A activation was inhibited by feeding in term but not in preterm pigs (P < 0.05).

CONCLUSIONS: Our results suggest that preterm birth impairs regulatory components involved in Akt activation, …

Forging New Therapeutic Targets: Efforts Of Tumor Derived Exosomes To Prepare The Pre-Metastatic Niche For Cancer Cell Dissemination And Dormancy, Ranvir Bhatia, Joanna Chang, Jessian L Munoz, Nykia D Walker

Faculty, Staff and Students Publications

Tumor-derived exosomes play a multifaceted role in preparing the pre-metastatic niche, promoting cancer dissemination, and regulating cancer cell dormancy. A brief review of three types of cells implicated in metastasis and an overview of other types of extracellular vesicles related to metastasis are described. A central focus of this review is on how exosomes influence cancer progression throughout metastatic disease. Exosomes are crucial mediators of intercellular communication by transferring their cargo to recipient cells, modulating their behavior, and promoting tumor pro-gression. First, their functional role in cancer cell dissemination in the peripheral blood by facilitating the establishment of a pro-angiogenic …

Synapse-Specific Changes In Arc And Bdnf In Rat Hippocampus Following Chronic Temporal Lobe Epilepsy, Daniel L Egbenya, Suleman Hussain, Yi-Chen Lai, Anne E Anderson, Svend Davanger

Faculty, Staff and Students Publications

Expression of immediate early genes (IEGs) in the brain is important for synaptic plasticity, and probably also in neurodegenerative conditions. To understand the cellular mechanisms of the underlying neuropathophysiological processes in epilepsy, we need to pinpoint changes in concentration of synaptic plasticity-related proteins at subsynaptic levels. In this study, we examined changes in synaptic expression of Activity-regulated cytoskeleton-associated (Arc) and Brai Derived Neurotrophic Factor (BDNF) in a rat model of kainate-induced temporal lobe epilepsy (TLE). Western blotting showed reduced concentrations of Arc and increased concentrations of BDNF in hippocampal synaptosomes in chronic TLE rats. Then, using quantitative electron microscopy, we …

X-Linked Variations In Shroom4 Are Implicated In Congenital Anomalies Of The Urinary Tract And The Anorectal, Cardiovascular And Central Nervous Systems, Caroline M. Kolvenbach, Tim Felger, Luca Schierbaum, Isabelle Thiffault, T Pastinen, Maria Szczepańska, Marcin Zaniew, Piotr Adamczyk, Allan Bayat, Öznur Yilmaz, Tobias T. Lindenberg, Holger Thiele, Friedhelm Hildebrandt, Katrin Hinderhofer, Ute Moog, Alina C Hilger, Bonnie Sullivan, Lauren E. Bartik, Piotr Gnyś, Phillip Grote, Benjamin Odermatt, Heiko M. Reutter, Gabriel C. Dworschak

Manuscripts, Articles, Book Chapters and Other Papers

Background: SHROOM4 is thought to play an important role in cytoskeletal modification and development of the early nervous system. Previously, single-nucleotide variants (SNVs) or copy number variations (CNVs) in SHROOM4 have been associated with the neurodevelopmental disorder Stocco dos Santos syndrome, but not with congenital anomalies of the urinary tract and the visceral or the cardiovascular system.

Methods: Here, exome sequencing and CNV analyses besides expression studies in zebrafish and mouse and knockdown (KD) experiments using a splice blocking morpholino in zebrafish were performed to study the role of SHROOM4 during embryonic development.

Results: In this study, we identified putative …

Ift74 Variants Cause Skeletal Ciliopathy And Motile Cilia Defects In Mice And Humans., Zeineb Bakey, Oscar A. Cabrera, Julia Hoefele, Dinu Antony, Kaman Wu, Michael W. Stuck, Dimitra Micha, Thibaut Eguether, Abigail O. Smith, Nicole N. Van Der Wel, Matias Wagner, Lara Strittmatter, Philip L. Beales, Julie A. Jonassen, Isabelle Thiffault, Maxime Cadieux-Dion, Laura Boyes, Saba Sharif, Beyhan Tüysüz, Desiree Dunstheimer, Hans W M Niessen, William Devine, Cecilia W. Lo, Hannah M. Mitchison, Miriam Schmidts, Gregory J. Pazour

Manuscripts, Articles, Book Chapters and Other Papers

Motile and non-motile cilia play critical roles in mammalian development and health. These organelles are composed of a 1000 or more unique proteins, but their assembly depends entirely on proteins synthesized in the cell body and transported into the cilium by intraflagellar transport (IFT). In mammals, malfunction of non-motile cilia due to IFT dysfunction results in complex developmental phenotypes that affect most organs. In contrast, disruption of motile cilia function causes subfertility, disruption of the left-right body axis, and recurrent airway infections with progressive lung damage. In this work, we characterize allele specific phenotypes resulting from IFT74 dysfunction in human …

The Detrimental Effects Of Peripartum Antibiotics On Gut Proliferation And Formula Feeding Injury In Neonatal Mice Are Alleviated With Lactobacillus Rhamnosus Gg, Alain Cuna, Marianne N. Nsumu, Heather Menden, Susana Chavez-Bueno, Venkatesh Sampath

Manuscripts, Articles, Book Chapters and Other Papers

Peripartum antibiotics can negatively impact the developing gut microbiome and are associated with necrotizing enterocolitis (NEC). The mechanisms by which peripartum antibiotics increase the risk of NEC and strategies that can help mitigate this risk remain poorly understood. In this study, we determined mechanisms by which peripartum antibiotics increase neonatal gut injury and evaluated whether probiotics protect against gut injury potentiated by peripartum antibiotics. To accomplish this objective, we administered broad-spectrum antibiotics or sterile water to pregnant C57BL6 mice and induced neonatal gut injury to their pups with formula feeding. We found that pups exposed to antibiotics had reduced villus …

Characterization Of Folic Acid, 5-Methyltetrahydrofolate And Synthetic Folinic Acid In The High-Affinity Folate Transporters: Impact On Pregnancy And Development, Ana M Palacios, Rachel A Feiner, Robert M Cabrera

Faculty, Staff and Students Publications

Folates are B vitamins that are essential for several molecular, cellular, and biological processes, including nucleotide synthesis, methylation, and methionine cycling. The physiological impacts of these processes on health also extend to cell proliferation, folate deficiency anemia, and reduction of the risk of birth defects during pregnancy. The primary objective of this study was to characterize the binding affinities of different folate forms, folic acid (FA), 5-methyltetrahydrofolate (5MTHF), and folinic acid, to the folate receptors α and β, and to the bovine milk folate binding protein. These three dietary forms of folate are found in enriched grains (FA), various fruits …

Babel, Daniel Horowitz

Dissertations, Theses, and Capstone Projects

This thesis is a series of three memoiristic essays around the vortex of identity. The first is an exploration of how childhood overmedication split the continuity of the author’s self-conception. The second traces the slipperiness of Jewish and Queer identifications detailing their synthesis in the klezmer revival in New York City in late 1980s and early 90s. The third is a polyphonic narration of the recovery of a lost klezmer’s life story in the face of the silence of time and slaughter.

An Offer You Cannot Refuse: Understanding The Elusive Construct Of "Voluntary" Plea Decisions, Melanie B. Fessinger

Dissertations, Theses, and Capstone Projects

Defendants often plead guilty in exchange for reduced punishments. Some argue that these reduced punishments are necessary for the functioning of the criminal justice system, whereas others argue that they are inherently coercive because they place a burden on the exercise of constitutional rights. This potential coercion is of concern because the constitution requires valid guilty pleas to be made by defendants voluntarily. However, “voluntary” is an elusive construct of which courts, scholars, and laypeople have differing definitions. Although limited research has focused specifically on perceptions of voluntary pleas, decades of research have shown that individuals generally perceive decisions more …

Metabolic Reprogramming In Kras-Driven Cancer Cells, Ahmet Hatipoglu

Dissertations, Theses, and Capstone Projects

Cancer cells require nutrient uptake for anabolic reactions needed for cellular growth and proliferation. The mammalian target of rapamycin (mTOR) is a key regulator of cellular growth that links nutrient availability and growth factor signals. mTOR mediated signaling pathways are often dysregulated in a wide range of cancers. We previously reported that KRas-driven cancer cells sense exogenous lipids via de novo production of phosphatidic acid, which ultimately activates both mTOR complexes – mTORC1 and mTORC2. Activated mTORC2 phosphorylates the survival kinase Akt at Ser 473 which is required for full Akt activation. A direct substrate of Akt and a major …

The Gilded Tropics: Winslow Homer And John Singer Sargent In Florida, 1886-1917, Theodore W. Barrow

Dissertations, Theses, and Capstone Projects

This dissertation examines the Floridian works of Winslow Homer and John Singer Sargent in the context of tourism, race, and the environment as perceptions of the tropics in an Anglo-American context. Both artists sojourned in Florida and produced a number of watercolors and related oils that not only testify to a rapidly-expanding tourist industry to the Sunshine State, but also update the Romantic myths of the tropics with a more sober, ironic Realist take. While Homer and Sargent continue to be popular subjects for studies and exhibitions on their own, this dissertation is the first to consider how their shared …

Play Makes Perfect: An Exploration Of Game And Play Elements In Composition And Performance, Gabrielle Chou

Dissertations, Theses, and Capstone Projects

This dissertation aims to explore the intersection of play and games in Western classical music and define a new category of pieces, “ludic pieces,” which contain play structures and game mechanics within their composition. Starting with surveying perspectives in ludology and ludomusicology, including those by Roger Caillois, Johan Huizinga, Jesper Juul, Katie Salen, and Eric Zimmerman, I will examine various definitions of a “game” and what its qualifying aspects are. I will then turn to music and consider pieces that interact with play and games without containing game structures, including examples of musical humor and pieces which evoke the imagery …

Transnational Ritual Poetics Of Blackness In Performance, Nina A. Mercer

Dissertations, Theses, and Capstone Projects

In this dissertation, I investigate transnational ritual poetics of Blackness through a historical, cultural, and spatial lens, centering my exploration on the recurrence of circles, the crossroads, and waterways. I show how these formal poetics activate Africana cosmologies, cosmogonies, and mythologies dramaturgically by centering contemporary New York City performance works that bring together dance, theatre, and music. I contextualize NYC performance case studies in relation to performance practices in contemporary Salvador da Bahia. I am particularly interested in how the recurrence of circles, the crossroads, and water as formal poetics catalyze interventions along contested water-ways and landscapes marked by Black …

Navigating Through World’S Military Spending Data With Scroll-Event Driven Visualization, Hong Beom Hur

Dissertations, Theses, and Capstone Projects

Catching up with the current geopolitical event is more important than ever these days. Anti-western nations like Russia, China, Iran, and North Korea constantly challenge the world order set by the United States and its close allies. As a result, the world has seen a rise in military spending consecutively for the last several years. This data visualization project aims to provide an easy-to-read summary of military spending data published by the Stockholm International Peace Research Institute for hotly conflicted regions: East Asia, Europe, and the Middle East.

Scroll-event-driven visualization implemented using Scrollama.js and D3.js combines text, map, and data …

Modulatory Effects Of Schreckstoff On The Startle Escape Response Of Goldfish (Carassius Auratus), Denis Shor

Dissertations, Theses, and Capstone Projects

Fish face a variety of stressors in nature, a prominent one being a predatory threat to which they respond with an adaptive behavioral response thus maximizing their chances of survival. A primary anti-predatory behavior is a startle response or C-start. This behavior is controlled by two large reticulospinal neurons, the Mauthner cells (M-cells) which integrate multimodal sensory inputs. Detecting a predator involves various sensory information such as visual and mechanosensory cues but also olfaction. Indeed, following an attack, an injured fish will release an alarm pheromone (Schreckstoff) and thus acutely alert close by conspecifics. However, whether the alarm pheromone in …