Digital Commons Network^™

Memetic Epidemiology: A Mathematical Model For Tracking The Spread Of Linguistic Features Across Western Europe, Benjamin Shavitz

Dissertations, Theses, and Capstone Projects

The goal of this dissertation is to introduce a powerful new method for demonstrating the role of contact in potential cases of linguistic contact spread, Memetic Epidemiology, that can facilitate extensive future research. This dissertation introduces and demonstrates the use of this method on examples from Western and Central Europe.

Part I begins by providing theoretical background for Memetic Epidemiology using understandings, including Memetics, and Evolutionary Phonology and its extensions. Part I proceeds to lay out the objective of Memetic Epidemiology: to provide a new means of demonstrating that contact influenced the rise of linguistic features in certain languages during …

Conservative And Cultural Clashes With Comprehensive Sexuality Education, Bryan Z. Anderson

Dissertations, Theses, and Capstone Projects

This thesis analyzes the multifaceted debate over the use of comprehensive sexuality education (CSE) in United States public schools, while also emphasizing the ways in which withholding CSE is a strategy to uphold the white supremacist patriarchy. The work begins by historically framing the evolution of sexuality education through the United States’ history. This leads to the current discourse around CSE and the ways in which it is the optimal support for American youth today. After setting this foundation, the thesis looks at conservative figures and groups who are seeking to prevent public school adoption of CSE standards, as well …

The Development Of Novel Radioimmunoconjugates For The Pet Imaging And Radioimmunotherapy Of Cancer, Samantha M. Sarrett

Dissertations, Theses, and Capstone Projects

Antibodies have long played a vital role in nuclear medicine for both the diagnosis and therapy of various malignancies. The role and development of antibodies in nuclear medicine can be broadly separated into three different categories: 1) bioconjugation strategies, 2) immunoPET imaging, and 3) radioimmunotherapy. This dissertation will attempt to comprehensively cover each of these categories through a series of studies, protocols, and reviews. For the bioconjugation strategies, we will describe the development of a novel site-selective bioconjugation strategy using an innovative lysine-targeting reagent, PFP-bisN₃, to prepare [⁸⁹Zr]Zr-^SSKDFO-pertuzumab for visualizing HER2+ breast cancer. Further, …

Mood: A Zine Exploring The Value Of Youth-Oriented Media, Patricia K. Paul

Dissertations, Theses, and Capstone Projects

Media is a constant, persistent force in human lives that informs and influences through published, broadcasted, and digitally mediated formats. Mass media industries produce and distribute content consumed by diverse audiences, though the facilitators represent only a fraction of the demographics they serve.

Youth denote one of the most frequently misrepresented groups, with very few practical opportunities for young people to make decisions about the texts available to them. A jarring absence of youth participation in media creation at all levels suggests cultural contributions through art exclude young people's authentic perspectives and desires. Moreover, media portrayals of youth cannot adequately …

Feeling Otherwise: Affective Enactments Of Teaching And Learning Among Youth Researchers And Early-Career Teachers In A Cross-Course University Collaboration, Karen Zaino

Dissertations, Theses, and Capstone Projects

This study examines a cross-collaboration between early-career teachers enrolled in a graduate action research class and youth researchers taking part in a dual-enrollment youth participatory action research (YPAR) class at the same university. Grounded in critical youth studies, anti-colonial theories of the human, and queer-feminist studies in its approach to relationality, and drawing from transcripts of the combined class sessions and individual follow-up interviews, this critical narrative analysis seeks to understand how participants enact and experience the collaboration, with particular attention to how they understand and engage with one another. This study especially attends to the affective-discursive practices that participants …

Economic Factors And Theories Of Decline And Reform In The Late Ottoman Empire C. 1789–1911, Peter S. Gomori

Dissertations, Theses, and Capstone Projects

Tribes of Turkish speaking people (“Turks”) migrated in the 11th century from the Central Asian Steppes to what we consider the Middle East. Over the next two centuries this community would expand north, west and south to form a vast empire: the Ottoman Empire. Possibly the peak of the size of this empire would probably occur during the 16^th century under the rule of the Sultan, Suleiman the Magnificent (1494- 1566) where the population of the Ottoman Empire was estimated to be up to 30 million. Yet there would be rivals. To the East was the Safavid Empire (today …

Barriers To Optimal Audiological Care For Members Of The Deaf Community, Joyce Orenshein

Dissertations, Theses, and Capstone Projects

Background:

The purpose of this study was to identify the barriers to optimal audiological care for members of the Deaf community from the perspectives of Deaf individuals compared to audiologists. The goal is to help bridge the clinical communication barriers that lie between audiologists and the Deaf community by identifying the perceived gaps in care specifically and by gathering suggestions for improvement. A survey was administered to both audiologists and members of the Deaf community, making the present study unique and essential in that responses from both communities are compared and suggestions for bridging the gap are made.

Methods …

The Persephone Series: Storytelling, Art, And Making Sense Of Myself, Katie M. Frank

Dissertations, Theses, and Capstone Projects

What can I do with what I already have? How can I make of it something beautiful, or useful, or interesting? Over the past two and a half years, I have been creating wall sculptures and collages out of found objects that speak to the history of my family, the way the earth reclaims its space after being used by humans, and how our individual lives have impact beyond our recognition. The people we love, the things we have lost, the garbage and grief we try to bury: it doesn’t go away. It comes back to the surface in shapes …

Bi Erasure And Bi Invisibility In Media And Medicine: Moving Beyond, Lacy M. Telles

Dissertations, Theses, and Capstone Projects

This project examines the bisexual erasure and invisibility that is found in film, television, literature, and in the field of reproduction. Even though bisexual people make up a large portion of the LGBTQ community, because of bi invisibility, they tend to get lost in the cause. This website offers information about bi invisibility, highlights obstacles faced by bisexuals, provides resources for bisexuals, and includes some fun topics for bisexual people. It also has a page of bisexual testimonies: real bi people with real bi stories. There is evidence of erasure and invisibility, especially in children’s books and the field of …

Haunted Homelands: Mary Hunter Austin's Search For Belonging In California's Central Valley, Aimee M. Maddalena

Dissertations, Theses, and Capstone Projects

From childhood, Mary Hunter Austin resisted the social conformity expected of a young girl in 1850’s Carlinville, Illinois. Instead, causing her mother to “shed tears of vexation,” she was outspoken, opinionated, and read the “wrong” books, which, according to her mother, “was what made you queer so that people didn’t like you.” Young Mary had a rich inner life and was drawn in a spiritual, mystical way to the minutiae of the natural world. Also, she questioned the strict social structure that caused her mother to be outcast as a widow, while, at the same time, young women were beginning …

Jus Soli And Jus Sanguinis: Politics, Race, Culture, And Citizenship In The Dominican Republic And Haiti, Guido A. Proano

Dissertations, Theses, and Capstone Projects

The promulgation of laws such as the Dominican Republic’s Constitutional Court’s Judgment TC-168-13 serves as a basis upon which to argue the major impediments presented by the Dominican government to deny Haitians and Dominicans of Haitians descent citizenship. The right to citizenship is based on legal principles of jus soli and jus sanguinis and is recognized in a series of international legal documents. Following a Marxist framework, this research demonstrates the uncounted possible relationships between modern social forces and politics that have been working closely following European productions of knowledge for decades against Haitians and Dominicans of Haitian descent in …

Open Fire: The Expansion Of 9mm Hollow Point Bullets In Relation To Tissue Thickness, Abigail Wilson

Student Theses

Bullets can be broadly differentiated into jacketed and unjacketed groups. Jacketed ammunition can be further broken down based on the bullet’s design, one of which is hollow points. This research examines a representative brand of jacketed hollow point bullets used in a common caliber cartridge, the 9mm Luger. A jacketed hollow point bullet is designed to expand when it encounters a viscous medium such as tissue. This experiment simulated tissue using ballistic gelatin and simulated skin using a chamois overlay. As a positive and negative control, a series of bullets were fired into a full-size block of gelatin to achieve …

Magnesium Increases Numbers Of Foxp3+ Treg Cells And Reduces Arthritis Severity And Joint Damage In An Il-10-Dependent Manner Mediated By The Intestinal Microbiome, Teresina Laragione, Carolyn Harris, Nasim Azizgolshani, Christine Beeton, Gerold Bongers, Percio S Gulko

Faculty, Staff and Students Publications

BACKGROUND: Rheumatoid arthritis (RA) is a common autoimmune disease with emerging environmental and microbiome risk factors. The western diet is typically deficient in magnesium (Mg), and there is some evidence suggesting that Mg may have anti-inflammatory properties. But the actual role of Mg supplementation in arthritis or in T cell subsets has not been explored.

METHODS: We investigated the role of a high Mg diet in two different mouse models of RA induced with the KRN serum, and collagen-induced arthritis. We also characterized the phenotypes of splenocytes, gene expression, and an extensive intestinal microbiome analyses including fecal material transplantation (FMT). …

Influence Of Age And Gender On Alveolar Bone Healing Post Tooth Extraction In 129 Sv Mice: A Microtomographic, Histological, And Biochemical Characterization, Cláudia Cristina Biguetti, Bhuvana Lakkasetter Chandrashekar, Gustavo Baroni Simionato, Nataira Regina Momesso, Marco Antonio Hungaro Duarte, Danieli C. Rodrigues, Mariza Akemi Matsumoto

School of Podiatric Medicine Publications

Objectives

To analyze the effect of biological sex and aging on craniofacial bone features in 129 Sv mice and their influence on dental socket healing post tooth extraction.

Materials and methods

A total of 52 129 Sv mice were used, of which 28 were young (3–4 months) and 24 were aged (17–18 months), equally distributed according to biological sex. After an upper right incisor extraction, mice specimens were collected at 7, 14, and 21-days post-surgery for microtomographic (microCT) and comprehensive histological analysis. Mandible, skull bones, and maxillae at 21 days were analyzed by microCT, while blood plasma samples were collected …

More (Sema|Meta)Phors: Additional Perspectives On Analogy Use From Concurrent Programming Students, Briana Christina Bettin, Linda Ott, Julia Hiebel

Michigan Tech Publications

A concurrent computing course is filled with challenges for upper-level programming students. Understanding concurrency provides deeper insight into many modern computing and programming language behaviors, but the subject matter can be difficult even for relatively proficient students. It can be a challenge to help students navigate and understand these unfamiliar topics. While there is a difference in general programming familiarity, teaching this novel material is not unlike some challenges faced when engaging introductory students with first programming concepts. In this work, we explore the use of analogy by students while learning a novel programming methodology. We investigate perceptions of the …

Protein Phosphatase 1 Γ Modulates Steady-State Bad Phosphorylation And Murine Platelet Survival, Masahiro Yanagisawa, Hyojeong Han, Subhashree Pradhan, Tanvir Khatlani, Deepika Subramanyam, K Vinod Vijayan

Faculty, Staff and Students Publications

No abstract provided.

The Concept Of Hadith, Meaning, And Position Of Hadith, Implementation And Comparison In Hadith Learning Application: Hadith Encyclopedia And Hadith Collection, Nurul Anggraeni Shinta Ilahi, Nurwahidin Nurwahidin, Mohammad Izdiyan

Journal Of Middle East and Islamic Studies

The rapid development of information and communication technology has added new perspectives to research on the concept of hadith, the meaning, and position of hadith, which can also be seen as an effort to improve, enforce, and preserve hadith among the Muslim community in the online realm. The results of this study identified two specific mobile applications, namely the Hadith Encyclopedia and the Hadith Collection. This research aims to test several mobile applications that can be used to speed up the learning process and show how simple the verification and authentication of a hadith is in modern times. Hadith data …

Exploring The Lexical And Contextual Meaning Of The Word “Zauj” In Quranic Discourse, Iqbal Fathi Izzudin, Muhammad Lukman Arifianto, Zulfa Azalia Mujahidah, Moh. Fery Fauzi

Al-Arabi: Journal of Teaching Arabic as a Foreign Language

Qur'an is the holy book of Muslims that contains religious teachings and serves as a guide to the life of all Muslims who demand to be studied and understood. One way to understand the meaning of the verse of the Qur'an is to study it from the point of

Studies On The Leukocyte-Associated Ig-Like Inhibitory Receptor-1 Signaling Pathway In T Lymphocytes, Chidi Zacheaus

Theses and Dissertations (ETD)

Inflammation is a natural process in which the immune system concertedly responds to pathogens and abnormal cell growth to protect the host. For an efficient/effective immune response that circumvents tissue atrophy, a delicate balance between stimulatory and inhibitory mechanisms is essential for the proper functioning of the immune system. Immuno-receptor Tyrosine-based Inhibitory Motif (ITIM)-bearing receptors in immune cells, including T lymphocytes, play a major role in preventing autoimmune responses. Leukocyte-associated Ig-like Inhibitory Receptor 1 (LAIR-1) is one of ITIM-bearing receptors. The mechanism by which LAIR-1 attenuates T-cell response has yet to be completely understood. In this study, I investigated a …

The Clinical And Molecular Spectrum Of The Kdm6b-Related Neurodevelopmental Disorder, Dmitrijs Rots, Taryn E Jakub, Crystal Keung, Adam Jackson, Siddharth Banka, Rolph Pfundt, Bert B A De Vries, Richard H Van Jaarsveld, Saskia M J Hopman, Ellen Van Binsbergen, Irene Valenzuela, Maja Hempel, Tatjana Bierhals, Fanny Kortüm, Francois Lecoquierre, Alice Goldenberg, Jens Michael Hertz, Charlotte Brasch Andersen, Maria Kibæk, Eloise J Prijoles, Roger E Stevenson, David B Everman, Wesley G Patterson, Linyan Meng, Charul Gijavanekar, Karl De Dios, Shenela Lakhani, Tess Levy, Matias Wagner, Dagmar Wieczorek, Paul J Benke, María Soledad Lopez Garcia, Renee Perrier, Sergio B Sousa, Pedro M Almeida, Maria José Simões, Bertrand Isidor, Wallid Deb, Andrew A Schmanski, Omar Abdul-Rahman, Christophe Philippe, Ange-Line Bruel, Laurence Faivre, Antonio Vitobello, Christel Thauvin, Jeroen J Smits, Livia Garavelli, Stefano G Caraffi, Francesca Peluso, Laura Davis-Keppen, Dylan Platt, Erin Royer, Lisette Leeuwen, Margje Sinnema, Alexander P A Stegmann, Constance T R M Stumpel, George E Tiller, Daniëlle G M Bosch, Stephanus T Potgieter, Shelagh Joss, Miranda Splitt, Simon Holden, Matina Prapa, Nicola Foulds, Sofia Douzgou, Kaija Puura, Regina Waltes, Andreas G Chiocchetti, Christine M Freitag, F Kyle Satterstrom, Silvia De Rubeis, Joseph Buxbaum, Bruce D Gelb, Aleksic Branko, Itaru Kushima, Jennifer Howe, Stephen W Scherer, Alessia Arado, Chiara Baldo, Olivier Patat, Demeer Bénédicte, Diego Lopergolo, Filippo M Santorelli, Tobias B Haack, Andreas Dufke, Miriam Bertrand, Ruth J Falb, Angelika Rieß, Peter Krieg, Stephanie Spranger, Maria Francesca Bedeschi, Maria Iascone, Sarah Josephi-Taylor, Tony Roscioli, Michael F Buckley, Jan Liebelt, Aditi I Dagli, Emmelien Aten, Anna C E Hurst, Alesha Hicks, Mohnish Suri, Ermal Aliu, Sunil Naik, Richard Sidlow, Juliette Coursimault, Gaël Nicolas, Hanna Küpper, Florence Petit, Veyan Ibrahim, Deniz Top, Francesca Di Cara, Raymond J Louie, Elliot Stolerman, Han G Brunner, Lisenka E L M Vissers, Jamie M Kramer, Tjitske Kleefstra

Faculty, Staff and Students Publications

De novo variants are a leading cause of neurodevelopmental disorders (NDDs), but because every monogenic NDD is different and usually extremely rare, it remains a major challenge to understand the complete phenotype and genotype spectrum of any morbid gene. According to OMIM, heterozygous variants in KDM6B cause "neurodevelopmental disorder with coarse facies and mild distal skeletal abnormalities." Here, by examining the molecular and clinical spectrum of 85 reported individuals with mostly de novo (likely) pathogenic KDM6B variants, we demonstrate that this description is inaccurate and potentially misleading. Cognitive deficits are seen consistently in all individuals, but the overall phenotype is …

Association Between Modifiable Social Determinants And Mental Health Among Post-9/11 Veterans: A Systematic Review, Nipa Kamdar, Sundas Khan, Diana P Brostow, Lia Spencer, Sharmily Roy, Amy Sisson, Natalie E Hundt

Faculty, Staff and Students Publications

Introduction: As U.S. Veterans reintegrate from active duty to civilian life, many are at risk for negative modifiable social determinants of health. The prevalence of mental health conditions among Veterans is also high. Awareness of the associations between these two factors is growing. This systematic review provides a comprehensive analysis of the current state of knowledge of the associations between modifiable social determinants and mental health among U.S. Veterans.

Methods: The authors systematically searched four databases and identified 28 articles representing 25 unique studies that met inclusion criteria. Findings from the studies were extracted and synthesized on the basis of …

Autophagy Prevents Early Proinflammatory Responses And Neutrophil Recruitment During Mycobacterium Tuberculosis Infection Without Affecting Pathogen Burden In Macrophages, Rachel L. Kinsella, Jacqueline M. Kimmey, Asya Smirnov, Reilly Woodson, Margaret R. Gaggioli, Sthefany M. Chavez, Darren Kreamalmeyer, Christina L. Stallings

2020-Current year OA Pubs

The immune response to Mycobacterium tuberculosis infection determines tuberculosis disease outcomes, yet we have an incomplete understanding of what immune factors contribute to a protective immune response. Neutrophilic inflammation has been associated with poor disease prognosis in humans and in animal models during M. tuberculosis infection and, therefore, must be tightly regulated. ATG5 is an essential autophagy protein that is required in innate immune cells to control neutrophil-dominated inflammation and promote survival during M. tuberculosis infection; however, the mechanistic basis for how ATG5 regulates neutrophil recruitment is unknown. To interrogate what innate immune cells require ATG5 to control neutrophil recruitment …

Replicative Acinetobacter Baumannii Strains Interfere With Phagosomal Maturation By Modulating The Vacuolar Ph, Jesus S. Distel, Gisela Di Venanzio, Joseph J. Mackel, David A. Rosen, Mario F. Feldman

2020-Current year OA Pubs

Bacterial pneumonia is a common infection of the lower respiratory tract that can afflict patients of all ages. Multidrug-resistant strains of Acinetobacter baumannii are increasingly responsible for causing nosocomial pneumonias, thus posing an urgent threat. Alveolar macrophages play a critical role in overcoming respiratory infections caused by this pathogen. Recently, we and others have shown that new clinical isolates of A. baumannii, but not the common lab strain ATCC 19606 (19606), can persist and replicate in macrophages within spacious vacuoles that we called Acinetobacter Containing Vacuoles (ACV). In this work, we demonstrate that the modern A. baumannii clinical isolate 398, …

Igg4 Antibodies To The Recombinant Filarial Antigen Wb-Bhp-1 Decrease Dramatically Following Treatment Of Lymphatic Filariasis, Sarah E. Greene, Yuefang Huang, Kurt C. Curtis, Christopher L. King, Peter U. Fischer, Gary J. Weil

2020-Current year OA Pubs

BACKGROUND: Lymphatic filariasis (LF) is a neglected tropical disease and a major cause of chronic disability. Improved diagnostic tests are needed because of long-term persistence of anti-filarial antibodies or circulating filarial antigenemia after treatments that clear microfilaremia. Here, we assess changes in levels of antibodies to the recombinant filarial antigens Wb-Bhp-1, Wb123, and Bm14 after anti-filarial treatment.

METHODOLOGY/PRINCIPAL FINDINGS: IgG4 antibodies to recombinant filarial antigens were assessed by ELISA. We tested serial plasma samples from a clinical trial in Papua New Guinea. Before treatment, 90%, 71% and 99% of participants had antibodies to Wb-Bhp-1, Wb123, and Bm14, respectively. Antibodies to …

Associations Between Socioeconomic Status, Obesity, Cognition, And White Matter Microstructure In Children, Zhaolong Adrian Li, Yuqi Cai, Rita L Taylor, Sarah A Eisenstein, Deanna M Barch, Scott Marek, Tamara Hershey

2020-Current year OA Pubs

IMPORTANCE: Lower neighborhood and household socioeconomic status (SES) are associated with negative health outcomes and altered brain structure in children. It is unclear whether such findings extend to white matter and via what mechanisms.

OBJECTIVE: To assess whether and how neighborhood and household SES are independently associated with children's white matter microstructure and examine whether obesity and cognitive performance (reflecting environmental cognitive and sensory stimulation) are plausible mediators.

DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study used baseline data from participants in the Adolescent Brain Cognitive Development (ABCD) study. Data were collected at 21 US sites, and school-based recruitment was used …

Involucrin Modulates Vitamin D Receptor Activity In The Epidermis, Alina D Schmidt, Charlene Miciano, Qi Zheng, Mary Elizabeth Mathyer, Elizabeth A Grice, Cristina De Guzman Strong

2020-Current year OA Pubs

Terminally differentiated keratinocytes are critical for epidermal function and are surrounded by involucrin (IVL). Increased IVL expression is associated with a near-selective sweep in European populations compared with those in Africa. This positive selection for increased IVL in the epidermis identifies human adaptation outside of Africa. The functional significance is unclear. We hypothesize that IVL modulates the environmentally sensitive vitamin D receptor (VDR) in the epidermis. We investigated VDR activity in Ivl

Impact Of Covid-19 On Latinx And Black Communities, Carolina Zuluaga

Dissertations

This critical literature review project explored the impact of COVID-19 on Latinx and Black communities. According to the Centers for Disease Control and Prevention, as of September 28, 2022, around 16% of COVID-19 cases in the United States were among Latinx people, and 14% of cases were among Black people (Centers for Disease Control and Prevention, 2022). Since COVID-19 began, clinicians have become more conscious of the effects of health disparities within racial and ethnic minorities, which has warranted increased advocacy by educating health and mental health providers and creating and providing resources to these communities and clinicians. The review …

Narratives Of Perseverance By Latina Women Paving Their Way To Success In Science, Technology, Engineering, Art, And Math (Steam) Higher Education, Toni Carmichael

Dissertations

The purpose of this narrative study was to understand the experiences of successful Latina women attaining higher education in Science, Technology, Engineering, Art, and Mathematics (STEAM) and the challenges they have overcome along the way. Additionally, I sought to examine ways in which these students challenged the stigma of invisibility often attached to Latino communities. Representatives from Brazil, Ecuador, El Salvador, and Mexico, the participants of this study were seven women employed in various areas of STEAM with higher education degrees.

Cultural Capital and Feminist Cultural Studies provided the theoretical framework for this study. The three-dimensional narrative design was applied …

Particle Arc Single-Isocenter Stereotactic Radiosurgery Of Multiple Brain Metastases, L Volz, S Mein, T Tessonnier, Peilin Liu, A Mairani, M Durante, Xuanfeng Ding, C Graeff, T Li

Conference Presentation Abstracts

Purpose: To develop spot-scanning proton (SPArc) and heavy ion (SHArc) arc therapy for single-isocenter stereotatic radiosurgery (SISRS) of multiple brain metastases (MBMs). First results achieved with dedicated planning infrastructure are compared to state-of-the -art volumetric modulated photon arc therapy (HA-VMAT). Methods: A multi-institutional collaboration was established to develop bespoke SPArc and SHArc SISRS infrastructure with available research and commercial treatment planning systems. Devised planning and delivery methods considered dedicated energy, spot, and multi-arc selection strategies. SPArc and SHArc (carbon and helium ions) plans were generated for MBM patients exhibiting 3-12 intracranial lesions with GTV volumes between 0.03ccm and 19.8ccm, at …

Transcriptional Differences In Identical Twins With Different Reproductive Capacities: A Case Report, Katherine Campbell, Alexandra Dullea, Christian Ramsoomair, Kyle Schuppe, Armin Ghomeshi, Kajal Khodamoradi, Himanshu Arora, Carolina Jorgez, Ranjith Ramasamy

Faculty, Staff and Students Publications

Disorders of sperm production can be classified quantitatively as oligospermia (low sperm count) or azoospermia (no sperm during ejaculation). Numerous genes have been implicated in spermatogenesis. We describe a case of two identical twins who presented with different reproductive capabilities. One brother was infertile due to azoospermia, and the other, although oligospermic, previously naturally fathered a child. They were found to have differential gene expression based on RNA sequencing analysis. In the man with azoospermia, we found elevated E2F1 and HOXB9 gene expressions when compared with his brother, suggesting that the increased RNA expression of these genes could influence sperm …