Digital Commons Network^™

Smooth Muscle-Alpha Actin R149c Pathogenic Variant Downregulates Integrin Recruitment At Cell-Matrix Adhesions And Decreases Cellular Contractility, Krishna R Ojha, Hyoseon Kim, Samuel Padgham, Laura Hopkins, Robert J Zamen, Abhijnan Chattopadhyay, Gang Han, Dianna M Milewicz, Michael P Massett, Andreea Trache

Faculty, Staff and Student Publications

Thoracic aortic aneurysm is found in patients with ACTA2 pathogenic variants. ACTA2 missense variants are associated with impaired aortic smooth muscle cell (SMC) contraction. This study tested the hypothesis that the Acta2R149C/+ variant alters actin isoform expression and decreases integrin recruitment, thus, reducing aortic contractility. Stress relaxation measurements in thoracic aortic rings showed two functional regimes with a reduction of stress relaxation in the aorta from Acta2R149C/+ mice at low tension, but not at high tension values. Contractile responses to phenylephrine and potassium chloride were 50% lower in Acta2R149C/+ mice than in wild-type (WT) mice. Additionally, SMC were immunofluorescently labeled …

Ocular Toxicity Profile Of Targeted Cancer Therapy (Tct) At A Us Tertiary Cancer Center, Moe Ameri, Nagham Al Zubidi, Azadeh Razmandi, Andrew Whyte, Aung Naing, Nimisha A Patel, Dan S Gombos

Faculty, Staff and Student Publications

PURPOSE: Targeted cancer therapy (TCT) is a significant advancement in oncology with promising survival improvement in patients with cancer and remarkable effects on various cancers. There is evidence suggesting a connection between specific TCT classes and the occurrence of immune-related adverse events (irAEs). Our study aims to investigate the potential ocular toxicities of different classes of TCT, provide a better understanding of these toxicities, and aid in the future development of screening and management recommendations for ocular irAEs.

DESIGN: Retrospective observational case series.

PARTICIPANTS: Only ocular immune-related AEs were included in the study; patients on TCT who received a new …

Metamaterial-Based Soft Actuators, Savannah June Cheney, Nathan Kessenich, Marco Leen, Merek Mcgill

Mechanical Engineering

For this project the team was tasked with designing a soft actuator that incorporated aspects of mechanical metamaterials. The team’s goal was to demonstrate the feasibility of structural metamaterials in the field of soft robotics and demonstrate a novel response with a final assembly. Also included in the team's discussion are the manufacturing steps, protype tests & results, and suggested future next steps. Following the previous report (critical design review) the team chose to follow the path of designing a continuum robot with metamaterials incorporated into the design. A continuum robot consists of a soft cylindrical body with rigid evenly …

Zero-Waste Ocean Floor Hydrophone Mooring, Chloe Schofield, German Jack Ellsworth, Jathun Somasundaram, Evan Brown

Mechanical Engineering

Maddie Schroth-Glanz, from the Statistics Department of Cal Poly, requires a system that assists in the deployment and retrieval of a marine hydrophone used to record ocean mammal vocalization patterns, specifically in large whales. This report discusses the final design, including changes to the design after the Critical Design Review, and the tests that were done to ensure the final design achieves the specifications of the project. We will discuss everything from material purchases to manufacturing and assembly for all subsystems of the project, and then discuss how our testing justified the design choices we made. Finally, the report will …

Therapeutic Mechanical Horse Project, Broghan Martin, Carson Roff, Zach Barnisham, Lydia Barnes

Mechanical Engineering

This project team created a simple mechanical model of a horse that disabled children could ride on to feel more comfortable partaking in equine therapy. This project was sponsored by Jack’s Helping Hand as part of their equine therapy program. The team went through the entire design process of researching, ideating, prototyping, and testing to create the final product. Finite element analysis of the structural members of the horse was performed. The forces used in that model were later validated through testing of the strength of those same members after manufacturing. In the end, a self-actuating single degree of freedom …

Disc Golf Throwing Robot, Nevada S. Schultz, Sydney M. Lewis, Erick Edmundo Daza, Rachel Alysse Greenberg, Peter M. Kean

Mechanical Engineering

Disc golf companies need better methods to test disc flight. The scope of this project is to create a disc throwing robot that can throw a disc golf driver 450-500 feet, with control over the speed, spin, and release angle. Research shows that multiple disc-throwing products exist; however, none meet the full requirements of this project. The Cal Poly senior project design team created a proof-of-concept machine. This prototype started as a two-wheel mechanism. Eventually, a third wheel was added, allowing for complete control over disc spin. The three-wheel prototype reached 62 mph when perfectly calibrated. The prototype is accurate, …

Reformed Worship (Rw) 148 - Justice (June 2023), Reformed Worship Editors

Reformed Worship Magazine

Editorial: It Starts with the Land by Joyce Borger....2

Worship Series: The Art of Neighboring by Laura de Jong....3

Creation Care, Coal, and the Greatest Commandment by Kyle Meyaard-Schaap....11

A Prayer for the Flourishing of Bees by Joyce Borger....14

The Season of Creation by Rachel Mash and Suzana Moreira....15

Singing Creation by Debra and Ron Rienstra....20

Being a Good Guest by Adrian Jacobs....26

The Land We Stand On by Sam Cooper, Janina Krabbe, Silas Krabbe, and Jacqui Mignault....33

God Is a Homemaker by Jessica Maddox....40

For Pastors: To Preach Justice by …

Home Based Business Ordinance For The City Of Reno, Maxwell Hp Johnson

City and Regional Planning

Home based businesses allow for some commercial and business activities to occur within private residences by residents without the need of commercially zoned properties or structures. Home based businesses provide affordable accommodation for less impactful small businesses, but can additionally impact neighbors and communities with negative externalities when not properly regulated. The City of Reno, Nevada currently faces rising land prices and limited availability of commercial properties. Such conditions increase the adoption of home based businesses, and combined with the lack of regulation can create nuisances within communities.

The ordinance proposal analyzes relevant legal cases, case study ordinances, and the …

The Guardian The Month Of June 2023, Wright State Student Body

The Guardian Student Newspaper

News articles from The Guardian for the Month of June 2023. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.

Ipulse: June 2023, Lynn University

Student Newspapers

Issue:

• June 2023 [Summer Week #1]: A Campus Transformation for the Ages - All of Them; The Story Behind the Flags; In the Center of Campus: A Wellness Center Coming Soon; An Unforgettable Summer; Shining Knights of Boca; Lynn is a Hotbed for Sports Media; Summer Comes, Students Go; Lynn to the Max

Fraught Aging And Frayed Social Networks, Laura Zimmer-Tamakoshi

Pacific Studies

This article looks at the challenges of aging in Gende society and why the Papua New Guinea government should consider a safety net for more vulnerable populations. It begins with an overview of how the Gende used their exchange system over many generations to deal with periods of extreme uncertainty and inequality. Investing in a moral economy that encouraged gender equality and expansive kin relations and obligations, the Gende weathered tribal warfare that drove them off their traditional lands long ago. Moving into sparsely populated mountains in what is now Madang Province, Gende became middlemen in trade routes connecting the …

Analysis Of Research Papers On The Use Of English Movies In Chinese Senior High School English Teaching In The Past Three Years, Peiyuan Lin, Hong Mei

Journal of Educational Technology Development and Exchange (JETDE)

Much attention has been paid to using English movies in senior high school English teaching in China since the release of 2017 edition of Senior High School English Curriculum Standards that lists English Movie Appreciation as an optional compulsory course. Senior high school teachers have conducted substantial research over the past three years regarding the practical application of English movies in their teaching, yet there has been a lack of thorough and systematic of analysis of the large number of relevant papers published, which, more or less, limits the understanding and further advancements of this study area. This paper attempts, …

A Randomized Clinical Trial Of Behavioral Activation And Exposure-Based Therapy For Adults With Generalized Anxiety Disorder., Hannah Berg, Elisabeth Akeman, Timothy J. Mcdermott, Kelly T. Cosgrove, Namik Kirlic, Ashley Clausen, Mallory Cannon, Hung-Wen Yeh, Evan White, Wesley K. Thompson, Emily M. Choquette, Cassandra A. Sturycz-Taylor, Gabe Cochran, Sam Ramirez, Christopher R. Martell, Kate B. Wolitzky-Taylor, Michelle G. Craske, James L. Abelson, Martin P. Paulus, Robin L. Aupperle

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: Exposure-based therapy (EXP) and behavioral activation (BA) are empirically-supported behavioral intervention techniques that target avoidance and approach behavior to alleviate symptoms. Although EXP is an established treatment for generalized anxiety disorder (GAD), the effectiveness of BA for GAD has not been directly tested or compared with that of EXP. This study examined the efficacy of EXP and BA for adults with GAD.

METHOD: In a randomized clinical trial (clinicaltrials.gov: NCT02807480) with partial blinding in Tulsa, OK, 102 adults with GAD were allocated to manualized, 10-session EXP or BA between April 2016-April 2021. Primary analyses were intention-to-treat and included the …

Vol. 43, No. 3, Summer 2023: Table Of Contents, Northern Illinois University Law Review

Northern Illinois University Law Review

Table of Contents and Masthead for Volume 43, Issue 3 of the Northern Illinois Law Review

Notes For A New Legal Research Pedagogy, Nicholas Mignanelli

Northern Illinois University Law Review

Do societal power structures shape the organization of legal information? Do they embed biases in legal research tools? If so, how can the insights of critical legal theory assist us in contending with this phenome-non? An entire body of scholarly literature using the lenses of critical legal studies, feminist legal theory, and Critical Race Theory to examine legal information and the legal research process has grown up around answering these questions. However, the theories, methods, and strategies proffered by the scholars writing in this area are rarely taught in the legal research classroom.

I begin this Essay with a discussion …

The Skin I’M In: A Critical Content Analysis Of Picture Books Written By Black Authors, Angela Latrece Justice

Dissertations

This study seeks to explore the experiences of Black male protagonists in picture books. The following question guided this study: How do Black authors demonstrate a commitment to social justice? The theoretical framework that guides this study is Critical Race Theory (CRT), which aids in understanding how Black authors use experiential knowledge to represent experiences that challenge dominant ideologies about Black males. The sample consists of 20 pictures books all written by Black authors and published within the United States from 2018 to 2021. The deductive and inductive approaches to critical content analysis is used as it is effective for …

Commencement Program 2023, Loma Linda University

Commencement Programs

CONTENTS

1 | Message from the President

3 | 2023 Events of Commencement

5 | The Academic Procession

6 | Institutional Administration

7 | Board of Trustees

8 | Significance of Academic Regalia

9 | University History Highlights

11 | Criteria for Institutional Awards

13 | Loma Linda University Health and Loma Linda University Honorees

25 | The Program, The School Honorees, and The Speakers

• School of Medicine, 26
• School of Pharmacy, 52
• School of Dentistry, 69
• School of Public Health, 93
• San Manuel Gateway College, 108
• School of Allied Health Professions—Allied Health Studies, Cardiopulmonary Sciences, Clinical Laboratory Science, Communication …

The Age Of Incoherence? Understanding Mixed And Unclear Ideology Extremism, Alexander Meleagrou-Hitchens, Moustafa Ayad, Program On Extremism, George Washington University, National Counterterrorism Innovation, Technology, And Education Center

Reports, Projects, and Research

In May 2019, the Federal Bureau of Investigation (FBI) issued an intelligence bulletin that included one of the first official acknowledgments of what they and other similar agencies in the West identified as an emerging violent extremist threat. It warned that “anti-government, identity based, and fringe political conspiracy theories” were playing an increasing role in motivating domestic extremists to commit criminal, sometimes violent, acts. Since then, officials have also noted the emergence of individuals acting based on “salad bar ideology” extremism, a term used in 2020 by FBI Director Christopher Wray to describe the nature of some of the recent …

Seminarians In The Person-Of-The-Therapist (Pott) Training : A Phenomenological Study, Tomichan Moonnanappillil

Dissertations

This dissertation presented a transcendental phenomenological study conducted among eight seminarians in one of the theological schools in Southern Texas, who attended the personof-the- therapist (POTT) training program during the fall semester of 2019. This study aimed to examine seminarian participants' experiences in POTT training, their influence on their selfawareness, and their impact on their emotional maturity and the ability to make responsible life choices. The study was guided by an existential-humanistic philosophical orientation as an overarching theoretical orientation with the subjective epistemological worldview and socialconstructionism paradigm. Findings indicated POTT training positively impacted seminarian participants' human formation, which was foundational …

Dietary Parental Effects In A Generalist Heribivore, Emma J. Sellers

Undergraduate Theses, Capstones, and Recitals

The environment or experiences of a parent generation can impact the fitness of the next generation, a phenomenon known as parental effects. The parental diet, for example, can have consequences for their offspring who may perform better or worse on the same diet. Dietary specialists are often the focus of studies of parental effects due to diet because a narrow diet breadth suggests that the offspring environment may be predictable. Dietary generalists, in contrast, are less often studied regarding parental effects and this may be because their wide diet breadth makes the future environment less predictable.

We investigated whether parental …

(R2032) Modeling The Effect Of Sanitation Effort On The Spread Of Carrier-Dependent Infectious Diseases Due To Environmental Degradation, Ram Naresh, Sandhya Rani Verma, J. B. Shukla, Manju Agarwal

Applications and Applied Mathematics: An International Journal (AAM)

In this present study, an SIS model is proposed and analyzed to study the effect of sanitation effort in controlling the spread of carrier-dependent infectious disease in a human habitat due to environmental degradation. The dynamics of the model consist of six dependent variables, the susceptible population density, infective population density, carrier population density, cumulative density of environmental degradation and the density of sanitation effort applied on carrier population and degraded environment. In the modeling process, the carrier population density and sanitation effort are modeled logistically and the degradation of the environment is assumed to be directly proportional to the …

Human Activities And Species Biological Traits Drive The Long-Term Persistence Of Old Trees In Human-Dominated Landscapes, Li Huang, Cheng Jin, Yingji Pan, Lihua Zhou, Siwei Hu, Yanpei Guo, Yuanyuan Meng, Kun Song, Mingyue Pang, Hong Li, Dunmei Lin, Xiaoting Xu, Jesse Minor, Chris Coggins, C. Y. Jim, Enrong Yan, Yongchuan Yang, Zhiyao Tang, David B. Lindenmayer

All Faculty Scholarship

Old trees have many ecological and socio-cultural values. However, knowledge of the factors influencing their long-term persistence in human-dominated landscapes is limited. Here, using an extensive database (nearly 1.8 million individual old trees belonging to 1,580 species) from China, we identified which species were most likely to persist as old trees in human-dominated landscapes and where they were most likely to occur. We found that species with greater potential height, smaller leaf size and diverse human utilization attributes had the highest probability of long-term persistence. The persistence probabilities of human-associated species (taxa with diverse human utilization attributes) were relatively high …

Potential Impacts Of Environmental Bacteria On The Microbiota Of Loggerhead (Caretta Caretta) And Green (Chelonia Mydas) Sea Turtle Eggs And Their Hatching Success, Colleen Mcmaken, Derek Burkholder, Rosanna J. Milligan Dr., Jose V. Lopez

Biology Faculty Articles

Sea turtle hatching success can be affected by many variables, including pathogenic microbes, but it is unclear which microbes are most impactful and how they are transmitted into the eggs. This study characterized and compared the bacterial communities from the (i) cloaca of nesting sea turtles (ii) sand within and surrounding the nests; and (iii) hatched and unhatched eggshells from loggerhead (Caretta caretta) and green (Chelonia mydas) turtles. High throughput sequencing of bacterial 16S ribosomal RNA gene V4 region amplicons was performed on samples collected from 27 total nests in Fort Lauderdale and Hillsboro beaches in …

Green Synthesis Of Nano Binary Oxide Sio2/V2o5 Nps Integrated Ointment Cream Application On Wound Dressings And Skin Cancer Cells, Marwa Ali, Abbas A-Ali Drea

Baghdad Science Journal

Green synthesis is depending on preparation of nano composited SiO2/V2O5 by using the modified sol-gel method depending on rice husk ash as a source for the extraction of silica gel and the product powder of nano composited SiO2/V2O5 characterization by many techniques such as X-ray diffraction spectroscopy (XRD), field emission scanning electron microscopy (FESEM), and N2 adsorptions/desorption isotherms (BET). This study also includs the biological effectiveness of SiO2/V2O5 and its effect on inhibiting bacterial growth after the prepared nanomaterial was applied to wound dressings, which gave a promising result for its use as topical dressings that remove microbes especially for …

Modeling The Power Grid Network Of Iraq, Rasha Al-Jarah, Manar Y. Kashmola

Baghdad Science Journal

Recently, the theory of Complex Networks gives a modern insight into a variety of applications in our life. Complex Networks are used to form complex phenomena into graph-based models that include nodes and edges connecting them. This representation can be analyzed by using network metrics such as node degree, clustering coefficient, path length, closeness, betweenness, density, and diameter, to mention a few. The topology of the complex interconnections of power grids is considered one of the challenges that can be faced in terms of understanding and analyzing them. Therefore, some countries use Complex Networks concepts to model their power grid …

Replaced By Ai: Developing A Kuyperian Philosophy Of Work In The Face Of Advancing Artificial Intelligence, Erin Holmberg

Pro Rege

Erin Holmberg, a Dordt University junior and Kuyper Honor Student majoring in Computer Science, submitted this essay to the Lambertus Verberg Prize for Excellence in Kuyperian Scholarship competition, 2023.

Wonder World, Liam M. Shaw, Briana Kuo

Computer Engineering

The main motivation for this project stems from a mutual lifelong love for video games, specifically sandbox games. These types of games, such as Mojang's Minecraft, ConcernedApe's Stardew Valley, and many more, have consistently provided us comfort in stressful times throughout our lives. Now, at the culmination of our undergraduate experience, the curriculum we have experienced throughout these past four years has provided us with the knowledge and resources that allows us to provide this same sense of comfort for others. Our game aims to encourage collaboration between two players through solving puzzles and minigames. In addition, our game seeks …

Filters For Fiji: A Modified Cracker Box Biosand Filter For Rural Fiji, Geneva Newell, Cameron Lowrey, Thomas Burt, Lexie Caterine

Civil and Environmental Engineering

Water quality remains a major issue throughout rural Fiji, as current solutions rely on outside organizations providing money or technology. The goal of Filters for Fiji’s research was to develop a sustainable water filtration method for the people of rural Fiji, through ethnographic and biological research. In order to be sustainable, the filter had to be inexpensive (less than USD$15), simply built and maintained, and suitable for the end-user. The driving question of the research was: can a plastic, modified biosand filter be constructed from materials that could be sourced locally in rural Fijian communities? To answer this question, feedback …

Boden Lecture: The Past’S Lessons For Today: Can Common-Carrier Principles Make For A Better Internet?, James B. Speta

Marquette Law Review

None.

The Nagging In Our Ears And Original Public Meaning, Perry Dane

Marquette Law Review

The debate over how to understand the meaning of legal texts once pitted intentionalism against a variety of other views united by the conviction that a legal enactment takes on a meaning not reducible to anybody’s mental state. Both these approaches are supported by powerful intuitions. This Article does not try to referee between them. Instead, it takes aim at a third set of views— theories of “original public meaning”—that in recent decades has upended the traditional debate and has now become gospel for the new majority on the United States Supreme Court.