Digital Commons Network^™

Genetically Caused Oral Disorders: Pathogenesis And Treatment: A Review, Ali Alsuraifi, Abdullah Ayad, Yousif Husam, Noor Alhuda R. Mohammed, Fatimah H. Mahdi, Jassem Mohammed, Zainab M. Sulaiman, Sarah Kareem

Al-Ameed Journal for Medical Research and Health Sciences

The mouth is a unique and intricate structure composed of various anatomical components that work together effectively to perform various functions. The oral cavity can be affected by various disorders, such as genetic diseases, infections, and metabolic disorders. A wide range of genetic disorders can affect the skeletal system, including craniofacial structures and teeth. These disorders exhibit a significant variety in terms of their causes when they show up, and how severe they are. Genetics is a significant risk factor in the development of oral diseases. It affects the pattern of inheritance, which can be dominant, recessive, or both. The …

Testosterone Hormone ; Clinical Indications, Dysregulation And Therapeutic Methods, Talal Z. Al-Darawsha

Al-Ameed Journal for Medical Research and Health Sciences

Testosterone is a hormone primarily produced by the testicles in adult men and it is the basic male sex hormone and an anabolic steroid. Androgen is important for survival. It is influences a man's appearance and sexual development, stimulating sperm production and regulating sex drive. This hormone is a key growth factor in prostate gland. Prostatic cells stop thriving when testosterone levels fall and Prostate cancer cells shrink both benign and malignant. Testosterone deficiency is a clinical and biochemical syndrome that is linked to ageing and is characterized by typical symptoms and a testosterone deficiency in the blood. The number …

What Is Task-Oriented Training? A Scoping Review, Erin Halford, Samantha Jakubiszak, Kassidy Krug, Amanda Umphress

Student Journal of Occupational Therapy

Task-Oriented Training (TOT) is an proven stroke rehabilitation intervention with significant evidence-based research that supports its effectiveness. The absence of a clear definition has led to variability in research reporting and subsequent confusion with practical implementation. A consistent definition seeks to remedy this ambiguity to facilitate knowledge translation. The objective of this study was to determine a comprehensive definition of TOT that encapsulates previous definitions and descriptions in the literature. In order to derive this definition, a two stage scoping review process was conducted across four databases searching for articles on the use of TOT in adult stroke rehabilitation therapy. …

Reviews Of Books Centering Justice + Liberation, Beth Spinner, Leah Van Belle, Rachel Cwiek

Michigan Reading Journal

No abstract provided.

Cas Connections- 2024 Spring Term - January, Dean's Office College Of Arts And Science

CAS Connections

No abstract provided.

Households' Preferences For Alternative Renewable Energy Technologies: An Attribute-Based Choice Experiment Survey In Metro Manila, Philippines, Rosalina Palanca-Tan, Daniel Del Barrio Alvarez, Ruth S. Palanca, Nelson Matthew P. Tan, Gem B. Castillo, Dino Carlo A. Saplala, Nan Wang

Economics Department Faculty Publications

Using a choice-based conjoint analysis, we measured willingness to pay (WTP) for an increase in the share of specific Renewable Energy (RE) technologies, namely solar, wind, biomass, and small-scale hydropower. The study found that on average, Metro Manila (MM) households are WTP an additional 19.3% of their electricity bill for an additional 20% share of RE in electric power capacity that is sourced from solar power. The corresponding WTP for the other RE technologies are substantially lower - 11.9% for biomass, 10.5% for wind, and 9.8% for small-scale hydropower. The skewed preference for solar energy augurs well for the government's …

Broadscale Coral Disease Interventions Elicit Efficiencies In Endemic Disease Response, Kathryn A. Toth, Samantha F. Buckley, Hunter Noren, Karen L. Neely, Brian K. Walker

Marine & Environmental Sciences Faculty Articles

The presence and abundance of reef-building corals are crucial to the long-term existence of Caribbean coral reef ecosystems, providing both direct and indirect, local and global, ecological, economic, and social benefits. In 2014, stony coral tissue loss disease (SCTLD) was first identified in southeast Florida and remains endemic to the region, while continuing to spread throughout the Caribbean. Effective in situ intervention treatments using antibiotic paste can halt lesion progression on Montastraea cavernosa up to 90% of the time. This study investigated intervention activities over a three-year period to identify efficiencies in disease response. Since May 2019, 1,037 corals, >85% …

Sacred Nutrition: Asserting Indigenous Sovereignty And Rights Of Women And Nature To Ensure The Right To Food In The United States, Mariana Chilton, Phd, Mph

University of Miami International and Comparative Law Review

This Paper is a provocation to move beyond a standard human rights and right to food framework to encourage scholars, activists, and political leaders to engage in full throttle societal transformation. Ending hunger in the United States demands nothing less. The modern human rights framework is enshrined in the modern nation-state system that is rooted in the transatlantic slave trade, colonization, and genocide.1 Three primary ways in which these roots took hold were through land theft, rape, and starvation. Hence, to assert that integrating the right to food and freedom from hunger into nation-state constitutions or into national plans to …

The Rider (2024-01-16), Natalie Lapsley

The Rider Archives

Vol.9 No.15

Week Of January 16, 2024, Student Life

College, School and Department Newsletters, Magazines, and Journals

Your weekly hub for events, resources and updates.

Classification Of Colorectal Cancer Using Resnet And Efficientnet Models, Abhishek Ranjan, Priyanshu Srivastva, B Prabadevi, R Sivakumar, Rahul Soangra, Shamala K. Subramaniam

Physical Therapy Faculty Articles and Research

Introduction:

Cancer is one of the most prevalent diseases from children to elderly adults. This will be deadly if not detected at an earlier stage of the cancerous cell formation, thereby increasing the mortality rate. One such cancer is colorectal cancer, caused due to abnormal growth in the rectum or colon. Early screening of colorectal cancer helps to identify these abnormal growth and can exterminate them before they turn into cancerous cells.

Aim:

Therefore, this study aims to develop a robust and efficient classification system for colorectal cancer through Convolutional Neural Networks (CNNs) on histological images.

Methods:

Despite challenges in …

Resolving Acne With Optimized Adapalene Microspongeal Gel, In Vivo And Clinical Evaluations, Rania Yehia, Dalia Attia, M. M. Elmazar

Pharmacy

In our pursuit of enhancing acne treatment while minimizing side effects, we developed tailored Adapalene microsponges (MS) optimized using a Box–Behnken design 33. The independent variables, Eudragit RS100 percentage in the polymer mixture, organic phase volume, and drug to polymer percentage, were explored. The optimized formulation exhibited remarkable characteristics, with a 98.3% ± 1.6 production yield, 97.3% ± 1.64 entrapment efficiency, and a particle size of 31.8 ± 1.1 μm. Notably, it achieved a 24 h cumulative drug release of 75.1% ± 1.4. To delve deeper into its efficacy, we evaluated the optimized microspongeal-gel in vitro, in vivo, and clinically. …

The Respiratory Enzyme Complex Rnf Is Vital For Metabolic Adaptation And Virulence In Fusobacterium Nucleatum, Timmie A Britton, Chenggang Wu, Yi-Wei Chen, Dana Franklin, Yimin Chen, Martha I Camacho, Truc T Luong, Asis Das, Hung Ton-That

Faculty, Staff and Student Publications

The Gram-negative oral pathobiont Fusobacterium nucleatum can traverse to extra-oral sites such as placenta and colon, promoting adverse pregnancy outcomes and colorectal cancer, respectively. How this anaerobe sustains many metabolically changing environments enabling its virulence potential remains unclear. Informed by our genome-wide transposon mutagenesis, we report here that the highly conserved Rhodobacter nitrogen-fixation (Rnf) complex, encoded by the rnfCDGEAB gene cluster, is key to fusobacterial metabolic adaptation and virulence. Genetic disruption of the Rnf complex via non-polar, in-frame deletion of rnfC (ΔrnfC) abrogates polymicrobial interaction (or coaggregation) associated with adhesin RadD and biofilm formation. The defect in coaggregation …

Development And Validation Of A Nomogram For Predicting Pulmonary Infection In Patients Receiving Immunosuppressive Drugs, Chuxuan Luo, Yue Zhang, Jiajie Zhang, Chen Jin, Xiaolan Ye, Yan Ren, Huajuan Shen, Maosheng Chen, Yiwen Li, Qiang He, Guangbiao Xu, Lina Shao

Faculty, Staff and Student Publications

Objective: Pulmonary infection (PI), a severe complication of immunosuppressive therapy, affects patients' prognosis. As part of this study, we aimed to construct a pulmonary infection prediction (PIP) model and validate it in patients receiving immunosuppressive drugs (ISDs). Methods: Totally, 7,977 patients being treated with ISDs were randomised 7:3 to the developing (n = 5,583) versus validation datasets (n = 2,394). Our predictive nomogram was established using the least absolute shrinkage and selection operator (LASSO) and multivariate COX regression analyses. With the use of the concordance index (C-index) and calibration curve, the prediction performance of the final model was …

In-Patient Evolution Of A High-Persister Escherichia Coli Strain With Reduced In Vivo Antibiotic Susceptibility, Joshua B Parsons, Ashelyn E Sidders, Amanda Z Velez, Blake M Hanson, Michelle Angeles-Solano, Felicia Ruffin, Sarah E Rowe, Cesar A Arias, Vance G Fowler, Joshua T Thaden, Brian P Conlon

Faculty, Staff and Student Publications

Gram-negative bacterial bloodstream infections (GNB-BSI) are common and frequently lethal. Despite appropriate antibiotic treatment, relapse of GNB-BSI with the same bacterial strain is common and associated with poor clinical outcomes and high healthcare costs. The role of persister cells, which are sub-populations of bacteria that survive for prolonged periods in the presence of bactericidal antibiotics, in relapse of GNB-BSI is unclear. Using a cohort of patients with relapsed GNB-BSI, we aimed to determine how the pathogen evolves within the patient between the initial and subsequent episodes of GNB-BSI and how these changes impact persistence. Using

Tomato Seedling Performance In Commercial Organic Growing Media, Elizabeth Maynard, Wenjing Guan, Petrus Langenhoven, Lori A. Hoagland

Department of Horticulture & Landscape Architecture Faculty Publications

Healthy transplants are critical to productivity in the field. For certified organic production in the United States, seedlings must be grown in media that meet the standards of the US Department of Agriculture’s National Organic Program. Many commercial organic media options are available, they vary substantially in composition, and it is unknown to what extent this influences seedling performance. This project compared tomato (Solanum lycopersicum L.) seedling emergence and growth in seven commercially available media for organic production and evaluated posttransplant performance. Tomato seedlings were grown in greenhouses at Wanatah, West Lafayette, and Vincennes, IN, USA. Chemical characteristics of …

How To Overcome Poverty With Zakat, Eiman Ahmed Khaleel Alhashmi

All Works

This research paper explores the multifaceted role of Zakat in alleviating poverty within the Islamic economic framework. Emphasizing its significance in preserving wealth and promoting economic stability, the paper delves into various dimensions of Zakat, ranging from its impact on economic cycles to its flexible provisions that safeguard against inflation and recession. The study underscores Zakat's contribution to poverty eradication through the development of human capital, morally and materially, and its role in fostering goodwill and compassion in society. Additionally, the paper discusses Zakat as a tool for preserving wealth, demonstrating its ability to prevent economic crises and redirect money …

Ucc Minutes 1-16-24, Angela Brock

UCC Agendas/Minutes

No abstract provided.

Icc Agenda 1-16-24, Angela Brock

Individual Course Committee (ICC)

No abstract provided.

Approved Courses 1-16-24, Angela Brock

Individual Course Committee (ICC)

No abstract provided.

Stable, Neuron-Specific Gene Expression In The Mouse Brain, Osama Ahmed, Kingsley M. Ekumi, Francesco V. Nardi, Gulimiheranmu Maisumu, Khaled Moussawi, Eric D. Lazartigues, Bo Liang, Abraam M. Yakoub

School of Medicine Faculty Publications

Gene delivery to, and expression in, the mouse brain is important for understanding gene functions in brain development and disease, or testing gene therapies. Here, we describe an approach to express a transgene in the mouse brain in a cell-type-specific manner. We use stereotaxic injection of a transgene-expressing adeno-associated virus into the mouse brain via the intracerebroventricular route. We demonstrate stable and sustained expression of the transgene in neurons of adult mouse brain, using a reporter gene driven by a neuron-specific promoter. This approach represents a rapid, simple, and cost-effective method for global gene expression in the mouse brain, in …

State Of Utah Plaintiff/ Appellee V. Alan Dudley Hamberlin Defendant/ Appellant : Brief Of Appellant, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

On appeal from the Sixth Judicial District Court, Kane County, Honorable Mandy Larsen, District Court No. 211600067

Sean Reyes, Counsel for Appellee

Freyja Johnson, Rachel Phillips Ainscough, Counsel for Appellant

Puerulus Settlement Forecasting In A Harvest Strategy Evaluation Of The Rock Lobster Fishery In South Australia, Richard Mcgarvey, Adrian Linnane, John E. Feenstra, Janet M. Matthews, Lachlan J. Mcleay, Annabel Jones, Kyriakos Toumazos, Simon De Lestang

Fisheries Research Articles

Harvest strategies are utilised in the management of fishery resources globally. Critical to their success is harvest strategy evaluation, whereby future performance is assessed through projection modelling. Using the observed relationship between a puerulus settlement index and model-estimated recruitment, we evaluated a southern rock lobster (Jasus edwardsii) harvest strategy in South Australia. Short-to-medium puerulus settlement recruitment forecasting was incorporated into future projections of catch, catch per unit effort, and percent unexploited egg production (%UEP) during 2019–2022. Observed values of indicators that closely aligned with projected outputs indicated that puerulus forecasting underpinned reliable evaluation of future fishery performance. A …

Gene Editing Of Pigs To Control Influenza A Virus Infections, Taeyong Kwon, Bianca L. Artiaga, Chester D. Mcdowell, Kristin M. Whitworth, Kevin D. Wells, Randall S. Prather, Gustavo Delhon, Mark Cigan, Stephen N. White, Jamie Retallick, Natasha N. Gaudreault, Igor Morozov, Juergen A. Richt

School of Veterinary and Biomedical Sciences: Faculty Publications

Proteolytic activation of the hemagglutinin (HA) glycoprotein by host cellular proteases is pivotal for influenza A virus (IAV) infectivity. Highly pathogenic avian influenza viruses possess the multibasic cleavage site of the HA which is cleaved by ubiquitous proteases, such as furin; in contrast, the monobasic HA motif is recognized and activated by trypsin-like proteases, such as the transmembrane serine protease 2 (TMPRSS2). Here, we aimed to determine the effects of TMPRSS2 on the replication of pandemic H1N1 and H3N2 subtype IAVs in the natural host, the pig. The use of the CRISPR/Cas 9 system led to the establishment of homozygous …

Badger Ecology, Bovine Tuberculosis, And Population Management: Lessons From The Island Of Ireland, Andrew W. Byrne, Adrian Allen, Simone Ciuti, Eamonn Gormley, David J. Kelly, Nikki J. Marks, Nicola M. Marples, Fraser Menzies, Ian Montgomery, Chris Newman, Maria O’Hagan, Neil Reid, David M. Scantlebury, Peter Stuart, Ming-Shan Tsai

Publications

The European badger, Meles meles, is an important wildlife host for Mycobacterium bovis and contributes to the epidemiology of bovine tuberculosis (bTB) in cattle in several countries. The control of zoonotic diseases, such as bTB, is a central component of global One-Health strategies. Such strategies are complicated by human–wildlife conflicts, particularly where wildlife reservoirs are legally protected. The contrasting objectives of disease management and wildlife conservation, therefore, can require significant investment in research to support evidence-based policies. In Britain and Ireland, for example, badgers are a legally protected species but are also subject to lethal control and vaccination for …

Novel Species Of Triatoma (Hemiptera: Reduviidae) Identified In A Case Of Vectorial Transmission Of Chagas Disease In Northern Belize, Sarah M Gunter, Alisa Nelson, Alexander R Kneubehl, Silvia A Justi, Russell Manzanero, Emily Zielinski-Gutierrez, Claudia Herrera, Julie Thompson, Rajendra Mandage, Hans Desale, Adrianna Maliga, Kim Bautista, Shannon E Ronca, Francis Morey, Rafael Chacon Fuentes, Beatriz Lopez, Eric Dumonteil, Gerhaldine H Morazan, Kristy O Murray

Faculty, Staff and Students Publications

Chagas disease is a leading cause of non-ischemic cardiomyopathy in endemic regions of Central and South America. In Belize, Triatoma dimidiata sensu lato has been identified as the predominate taxon but vectorial transmission of Chagas disease is considered to be rare in the country. We recently identified an acute case of vector-borne Chagas disease in the northern region of Belize. Here we present a subsequent investigation of triatomines collected around the case-patient's home. We identified yet undescribed species, closely related to Triatoma huehuetenanguensis vector by molecular systematics methods occurring in the peridomestic environment. The identification of a T. cruzi-positive, novel …

Metabolomic Rewiring Promotes Endocrine Therapy Resistance In Breast Cancer, Songyeon Ahn, Jun Hyoung Park, Sandra L Grimm, Danthasinghe Waduge Badrajee Piyarathna, Tagari Samanta, Vasanta Putluri, Dereck Mezquita, Suzanne A W Fuqua, Nagireddy Putluri, Cristian Coarfa, Benny Abraham Kaipparettu

Faculty, Staff and Students Publications

Approximately one-third of endocrine-treated women with estrogen receptor-alpha positive (ER+) breast cancers (BC) are at risk of recurrence due to intrinsic or acquired resistance. Thus, it is vital to understand the mechanisms underlying endocrine therapy resistance in ER+ BC to improve patient treatment. Mitochondrial fatty acid β-oxidation (FAO) has been shown to be a major metabolic pathway in triple-negative BC (TNBC) that can activate Src signaling. Here, we found metabolic reprogramming that increases FAO in ER+ BC as a mechanism of resistance to endocrine therapy. A metabolically relevant, integrated gene signature was derived from transcriptomic, metabolomic, and lipidomic analyses in …

Susceptibility Of Toxoplasma Gondii To Autophagy In Human Cells Relies On Multiple Interacting Parasite Loci, Nicholas Rinkenberger, Alex Rosenberg, Joshua B Radke, Jaya Bhushan, Tadakimi Tomita, Louis M Weiss, L David Sibley

2020-Current year OA Pubs

Autophagy is a process used by cells to recycle organelles and macromolecules and to eliminate intracellular pathogens. Previous studies have shown that some stains of

Human Pluripotent Stem Cell Modeling Of Alveolar Type 2 Cell Dysfunction Caused By Abca3 Mutations, Yuliang L Sun, Erin E Hennessey, Hillary Heins, Ping Yang, Carlos Villacorta-Martin, Julian Kwan, Krithi Gopalan, Marianne James, Andrew Emili, F. Sessions Cole, Jennifer A. Wambach, Darrell N. Kotton

2020-Current year OA Pubs

Mutations in ATP-binding cassette A3 (ABCA3), a phospholipid transporter critical for surfactant homeostasis in pulmonary alveolar type II epithelial cells (AEC2s), are the most common genetic causes of childhood interstitial lung disease (chILD). Treatments for patients with pathological variants of ABCA3 mutations are limited, in part due to a lack of understanding of disease pathogenesis resulting from an inability to access primary AEC2s from affected children. Here, we report the generation of AEC2s from affected patient induced pluripotent stem cells (iPSCs) carrying homozygous versions of multiple ABCA3 mutations. We generated syngeneic CRISPR/Cas9 gene-corrected and uncorrected iPSCs and ABCA3-mutant knockin ABCA3:GFP …

Hormonal Basis Of Sex Differences In Anesthetic Sensitivity, Andrzej Z Wasilczuk, Cole Rinehart, Adeeti Aggarwal, Martha E Stone, George A Mashour, Michael S Avidan, Max B Kelz, Alex Proekt, Reccognition Study Group

2020-Current year OA Pubs

General anesthesia-a pharmacologically induced reversible state of unconsciousness-enables millions of life-saving procedures. Anesthetics induce unconsciousness in part by impinging upon sexually dimorphic and hormonally sensitive hypothalamic circuits regulating sleep and wakefulness. Thus, we hypothesized that anesthetic sensitivity should be sex-dependent and modulated by sex hormones. Using distinct behavioral measures, we show that at identical brain anesthetic concentrations, female mice are more resistant to volatile anesthetics than males. Anesthetic sensitivity is bidirectionally modulated by testosterone. Castration increases anesthetic resistance. Conversely, testosterone administration acutely increases anesthetic sensitivity. Conversion of testosterone to estradiol by aromatase is partially responsible for this effect. In contrast, …