Digital Commons Network^™

Exploring Parametric Concepts And Principles For Furniture And Interior Design, Klawkanlayaphon Sawatmongkhonkul, Eakachat Joneurairatana, Veerawat Sirivesmas

Interiority

This research explores the incorporation of parametric models into the algorithmic design process, specifically focusing on furniture and interior design. It presents a case of an experimental equation centred around a waffle honeycomb structure. The first part of the article reviews three decades of literature on parametric design, which comprises its background, history, theory, and essential concepts and applications. The second part investigates the parametric design process to uncover its potential for interior design applications. The combination of parametric equations with algorithms through the utilisation of multiple steps, such as conditional loops, efficiently designs intricate systems. An intricate system in …

Robots As Pirates, Henry H. Perritt Jr.

Catholic University Law Review

Generative AI has created much excitement over its potential to create new works of authorship in the literary and graphical realms. Its underling machine-learning technology works by analyzing the relations among elements of preexisting material in enormous databases assembled from publicly available and licensed sources. Its algorithms “learn” to predict “what comes next” in different types of expression. A complete system thus can become glib in creating new factual summaries, essays, fictional stories and images.

A number of authors of the raw material used by Generative AI engines claim that the machine learning process infringes their copyrights. Careful evaluation of …

Ai And 6g Into The Metaverse: Fundamentals, Challenges And Future Research Trends, Muhammad Zawish, Fayaz Ali Dharejo, Sunder Ali Khowaja, Saleem Raza, Steven Davy, Kapal Dev, Paolo Bellavista

Articles

Since Facebook was renamed Meta, a lot of attention, debate, and exploration have intensified about what the Metaverse is, how it works, and the possible ways to exploit it. It is anticipated that Metaverse will be a continuum of rapidly emerging technologies, usecases, capabilities, and experiences that will make it up for the next evolution of the Internet. Several researchers have already surveyed the literature on artificial intelligence (AI) and wireless communications in realizing the Metaverse. However, due to the rapid emergence and continuous evolution of technologies, there is a need for a comprehensive and in-depth survey of the role …

The Hmong Experience With Modern Healthcare Services When Medical Intervention Is Necessary, Kristina Mauk

Walden Dissertations and Doctoral Studies

No abstract provided.

Patient-Derived Models Of Cancer In The Nci Pdmc Consortium: Selection, Pitfalls, And Practical Recommendations, Amber N Habowski, Deepthi P Budagavi, Sandra D Scherer, Arin B Aurora, Giuseppina Caligiuri, William F Flynn, Ellen M Langer, Jonathan R Brody, Rosalie C Sears, Giorgia Foggetti, Anna Arnal Estape, Don X Nguyen, Katerina A Politi, Xiling Shen, David S Hsu, Donna M Peehl, John Kurhanewicz, Renuka Sriram, Milagros Suarez, Sophie Xiao, Yuchen Du, Xiao-Nan Li, Nora M Navone, Estefania Labanca, Christopher D Willey

Faculty, Staff and Student Publications

For over a century, early researchers sought to study biological organisms in a laboratory setting, leading to the generation of both in vitro and in vivo model systems. Patient-derived models of cancer (PDMCs) have more recently come to the forefront of preclinical cancer models and are even finding their way into clinical practice as part of functional precision medicine programs. The PDMC Consortium, supported by the Division of Cancer Biology in the National Cancer Institute of the National Institutes of Health, seeks to understand the biological principles that govern the various PDMC behaviors, particularly in response to perturbagens, such as …

Relevance Theory And The Social Realities Of Communication, Marilynn Johnson

Philosophy: Faculty Scholarship

A central tenet of theories of meaning in the Gricean tradition—such as Relevance Theory—is that others will come to believe certain things simply by recognizing our intentions to communicate. In this article I demonstrate that this is not equally the case for all interlocutors; some bear additional burdens. In particular, I argue that this can happen in two ways. First, I demonstrate how a response to persistent testimonial injustice can be understood in terms of Sperber and Wilson’s distinction between meaning-that and showing-that; a speaker who experiences repeated testimonial injustice will often move down the meaning vs. showing continuum. This …

Dorsal Hippocampus To Nucleus Accumbens Projections Drive Reinforcement Via Activation Of Accumbal Dynorphin Neurons, Khairunisa Mohamad Ibrahim, Nicolas Massaly, Hye-Jean Yoon, Rossana Sandoval, Allie J Widman, Robert J Heuermann, Sidney Williams, William Post, Sulan Pathiranage, Tania Lintz, Azra Zec, Ashley Park, Robert W Gereau 4th, Jose A Morón, Et Al.

2020-Current year OA Pubs

The hippocampus is pivotal in integrating emotional processing, learning, memory, and reward-related behaviors. The dorsal hippocampus (dHPC) is particularly crucial for episodic, spatial, and associative memory, and has been shown to be necessary for context- and cue-associated reward behaviors. The nucleus accumbens (NAc), a central structure in the mesolimbic reward pathway, integrates the salience of aversive and rewarding stimuli. Despite extensive research on dHPC→NAc direct projections, their sufficiency in driving reinforcement and reward-related behavior remains to be determined. Our study establishes that activating excitatory neurons in the dHPC is sufficient to induce reinforcing behaviors through its direct projections to the …

Transmembrane Stem Factor Nanodiscs Enhanced Revascularization In A Hind Limb Ischemia Model In Diabetic, Hyperlipidemic Rabbits, Eri Takematsu, Miles Massidda, Gretchen Howe, Julia Goldman, Patricia Felli, Lei Mei, Gregory Callahan, Andrew D Sligar, Richard Smalling, Aaron B Baker

Faculty, Staff and Student Publications

Therapies to revascularize ischemic tissue have long been a goal for the treatment of vascular disease and other disorders. Therapies using stem cell factor (SCF), also known as a c-Kit ligand, had great promise for treating ischemia for myocardial infarct and stroke, however clinical development for SCF was stopped due to toxic side effects including mast cell activation in patients. We recently developed a novel therapy using a transmembrane form of SCF (tmSCF) delivered in lipid nanodiscs. In previous studies, we demonstrated tmSCF nanodiscs were able to induce revascularization of ischemia limbs in mice and did not activate mast cells. …

Effects Of Alcohol Consumption On Gambling Warning Message Recall And Recognition, Tori Horn

Electronic Theses and Dissertations Archive

Warning messages inform consumers of potential risks associated with product use and reduce the likelihood of excessive engagement in risky behaviors. Evidence supports that such messages can educate consumers and reduce gambling. Questions remain about how acute alcohol consumption may interfere with message reception and retention. Memory literature suggests that while alcohol consumption may not influence general message reception it may impact the recall of specific details of the messages. To examine this effect, participants (n = 82) were randomly assigned to consume alcoholic beverages (target blood alcohol concentrations of 0.06-0.08%) or juice. Participants then gambled on slot machines in …

Safety And Health Management Planning For Veterinarians, Jessie Salter, Michael Pate, Kerry A. Rood

All Current Publications

Veterinary staff health and safety are of primary importance to the profession. Although this is inherently understood, oftentimes, staff safety is not given the time and resources needed to promote a safe work environment free from unnecessary risks or exposures. This handbook educates clinic leaders on valuing and creating a safety culture in practice as well as implementing appropriate safety policies and procedures. Veterinary personnel are more likely to experience a work-related injury than policemen, firefighters, and construction workers. These statistics illustrate the need for a stronger safety culture in veterinary medicine. This handbook provides an outline on how to …

Chimes: January 29, 2024, Calvin University

Chimes

Invigorated by last year's momentum, Rangeela continues to grow by Maya Oeverman

Men's volleyball team kicks off their first season by Dillion Baumchen

Math Circle introduces local middle schoolers to mathematical thinking skills by Ethan Meyers

A rivalry for the common good: Calvin's SLC wraps up blood drive against Hope by Ewan Parker

Josh Steinberg wins gold with Team USA in Argentina by Lauren Nyong

A different kind of changing season: A conversation about the liturgical calendar by Nolan Cowan

Creating a tradition: The history of Calvin's January Series by Savannah Shustack

Sarah J. Maas's success comes at the expense …

Adult Neuromuscular Choristoma, A Rare Peripheral Nerve Pathology: Illustrative Case, Ashley Ricciardelli, Alex Flores, Hsiang-Chih Lu, Ekin Guney, Arie Perry, Joey Grochmal

Faculty, Staff and Students Publications

Background: Neuromuscular choristomas (NMCs) are rare tumors involving aberrant intercalation of muscle fibers into peripheral nerves, most commonly the sciatic nerve. Although benign, these lesions risk developing into NMCs with desmoid-type fibrosis (NMC-DTFs), aggressive lesions potentially requiring amputation. Currently, information on NMCs and the link between NMCs and NMC-DTFs is limited in adults, with the majority of cases reported in children. We present the case of a 66-year-old male with a sciatic NMC alongside a Preferred Reporting Items for Systematic Reviews and Meta-Analyses-based systematic review of similar cases to better characterize this lesion in the adult population.

Observations: A male …

Nowhere Stream, Rachel L. Wagner

Journal of Religion & Film

This is a film review of Nowhere Stream (2023), directed by Luis Grane.

Oxidative Stress And Ion Channels In Neurodegenerative Diseases, Razan Orfali, Adnan Z. Alwatban, Rawan S. Orfali, Liz Lau, Noble Chea, Abdullah M. Alotaibi, Young-Woo Nam, Miao Zhang

Pharmacy Faculty Articles and Research

Numerous neurodegenerative diseases result from altered ion channel function and mutations. The intracellular redox status can significantly alter the gating characteristics of ion channels. Abundant neurodegenerative diseases associated with oxidative stress have been documented, including Parkinson’s, Alzheimer’s, spinocerebellar ataxia, amyotrophic lateral sclerosis, and Huntington’s disease. Reactive oxygen and nitrogen species compounds trigger posttranslational alterations that target specific sites within the subunits responsible for channel assembly. These alterations include the adjustment of cysteine residues through redox reactions induced by reactive oxygen species (ROS), nitration, and S-nitrosylation assisted by nitric oxide of tyrosine residues through peroxynitrite. Several ion channels have been directly …

Important Features For Protein Foldings In Two Acyl Carrier Proteins From Enterococcus Faecalis, Seoyeong Yoo, Jiwon Yeon, Eunhee Kim, Yangmee Kim

Faculty, Staff and Student Publications

The emergence of multi-drug resistant Enterococcus faecalis raises a serious threat to global public health. E. faecalis is a gram-positive intestinal commensal bacterium found in humans. E. faecalis can endure extreme environments such as high temperature, pressure, and high salt, which facilitates them to cause infection in hospitals. E. faecalis has two acyl carrier proteins, AcpA (EfAcpA) in de novo fatty acid synthesis (FAS) and AcpB (EfAcpB) which utilizes exogenous fatty acids. Previously, we determined the tertiary structures of these two ACPs and investigated their structure-function relationships. Solution structures revealed that overall folding of these two ACPs is similar to …

Rates Of Reoperation In Duane Retraction Syndrome, Han Woong Lim, Bryce Hwang, Cyril Archambault, Scott Lambert

Wills Eye Hospital Papers

PURPOSE: To investigate the types of strabismus surgeries performed and the reoperation rate in patients with Duane retraction syndrome (DRS).

DESIGN: Retrospective cohort analysis.

PARTICIPANTS: An insurance claims data set was used to identify patients diagnosed with DRS between 2007 and 2021.

METHODS: We recorded the type of strabismus surgery performed and the timing and frequency of reoperations. The hazard ratios (HRs) for reoperation were estimated according to the surgical methods using Cox regression analysis.

RESULTS: Of the 9435 patients diagnosed with DRS, 1023 (10.8%) underwent ≥ 1 strabismus operation. The median age at surgery was 5.0 years, and patients …

Virtual Test Beds For Image-Based Control Simulations Using Blender, Akkarakaran Francis Leonard, Govanni Gjonaj, Minhazur Rahman, Helen E. Durand

Chemical Engineering and Materials Science Faculty Research Publications

Process systems engineering research often utilizes virtual testbeds consisting of physics- based process models. As machine learning and image processing become more relevant sensing frameworks for control, it becomes important to address how process systems engineers can research the development of control and analysis frameworks that utilize images of physical processes. One method for achieving this is to develop experimental systems; another is to use software that integrates the visualization of systems, as well as modeling of the physics, such as three-dimensional graphics software. The prior work in our group analyzed image-based control for the small-scale example of level in …

Aerodynamic Investigation Of Naca 0020 Airfoil With Extended And Serrated Trailing Edge At Various Turbulent Intensities, Livya E

Theses and Dissertations

Lift (upward force) is a significant aerodynamic component that directly relates to the aerodynamic efficiency (lift-to-drag ratio) of the airfoil. Enhancement of airfoil lift is important for industries like wind turbines, aircraft, and turbo machinery. The present study investigates the NACA series airfoil by modifying the trailing edge in the form of extension and serration. The angle of attack was changed from 0° to 35° instep of 5°, and the airflow Reynolds number was fixed as 2.14 × 105. To figure out the flow behavior, surface pressure has been collected from the 50 pressure ports provided over the airfoil surface. …

Immune Profiling In Puerto Rican Injection Drug Users With And Without Hiv-1 Infection, Sydney J. Bennett, Carmen Ana Davila, Zahiraliz Reyes, Aníbal Valentín-Acevedo, Kim Gocchi Carrasco, Roberto Abadie, M. Caleb Marlin, Marci Beel, Andrew G. Chapple, Samodha C. Fernando, Joel M. Guthridge, Kathy S. Chiou, Kirk Kirk, John T. West, Charles Wood

Department of Sociology: Faculty Publications

Antiretroviral therapy has been effective in suppressing HIV viral load and enabling people living with HIV to experience longer, more conventional lives. However, as people living with HIV are living longer, they are developing aging-related diseases prematurely and are more susceptible to comorbidities that have been linked to chronic inflammation. Coincident with HIV infection and aging, drug abuse has also been independently associated with gut dysbiosis, microbial translocation, and inflammation. Here, we hypothesized that injection drug use would exacerbate HIV-induced immune activation and inflammation, thereby intensifying immune dysfunction. We recruited 50 individuals not using injection drugs (36/50 HIV⁺) …

Thinking About The Public Trust Doctrine In A Modern Context As Applied To Non-Fungible Tokens, Dustyn Sams

Natural Resources Journal

This paper discusses two popular concepts in the legal world, the public trust doctrine and non-fungible tokens (NFTs). For the first time, it explores whether litigants could successfully use the doctrine to protect valuable NFTs. The public trust doctrine is the legal principle that the government holds and manages land under navigable water and closely associated natural resources in trust of the people. NFTs, on the other hand, are unique collections of cryptographical data that represent ownership of a digital artwork. This paper reconsiders the question of what exactly the scope of the public trust doctrine is and how its …

Reconstitution Of Human Pdac Using Primary Cells Reveals Oncogenic Transcriptomic Features At Tumor Onset, Yi Xu, Michael H Nipper, Angel A Dominguez, Zhenqing Ye, Naoki Akanuma, Kevin Lopez, Janice J Deng, Destiny Arenas, Ava Sanchez, Francis E Sharkey, Colin M Court, Aatur D Singhi, Huamin Wang, Martin E Fernandez-Zapico, Lu-Zhe Sun, Siyuan Zheng, Yidong Chen, Jun Liu, Pei Wang

Faculty, Staff and Student Publications

Animal studies have demonstrated the ability of pancreatic acinar cells to transform into pancreatic ductal adenocarcinoma (PDAC). However, the tumorigenic potential of human pancreatic acinar cells remains under debate. To address this gap in knowledge, we expand sorted human acinar cells as 3D organoids and genetically modify them through introduction of common PDAC mutations. The acinar organoids undergo dramatic transcriptional alterations but maintain a recognizable DNA methylation signature. The transcriptomes of acinar organoids are similar to those of disease-specific cell populations. Oncogenic KRAS alone do not transform acinar organoids. However, acinar organoids can form PDAC in vivo after acquiring the …

Influence Of Microbes In Mediating Sorghum Resistance To Sugarcane Aphids, Edith Ikuze, Stephanie Cromwell, Paul A. Ayayee, Joe Louis

Department of Entomology: Faculty Publications

Gut microbiomes profoundly influence insect health and mediate interactions between plant hosts and their environments. Insects, including aphids, harbour diverse obligate symbionts that synthesize essential nutrients and facultative symbionts that enhance host fitness in specific ecological contexts. Sorghum (Sorghum bicolor) is a significant cereal crop cultivated worldwide that has been negatively affected by the presence of an invasive piercing-sucking insect pest, the sugarcane aphid (SCA; Melanaphis sacchari). We previously identified SC265 and SC1345 as the resistant and susceptible sorghum lines, respectively, among the founder nested association mapping (NAM) population. Here, using these resistant and susceptible lines, we …

Single-Cell Multiomics Decodes Regulatory Programs For Mouse Secondary Palate Development, Fangfang Yan, Akiko Suzuki, Chihiro Iwaya, Guangsheng Pei, Xian Chen, Hiroki Yoshioka, Meifang Yu, Lukas M Simon, Junichi Iwata, Zhongming Zhao

Faculty, Staff and Student Publications

Perturbations in gene regulation during palatogenesis can lead to cleft palate, which is among the most common congenital birth defects. Here, we perform single-cell multiome sequencing and profile chromatin accessibility and gene expression simultaneously within the same cells (n = 36,154) isolated from mouse secondary palate across embryonic days (E) 12.5, E13.5, E14.0, and E14.5. We construct five trajectories representing continuous differentiation of cranial neural crest-derived multipotent cells into distinct lineages. By linking open chromatin signals to gene expression changes, we characterize the underlying lineage-determining transcription factors. In silico perturbation analysis identifies transcription factors SHOX2 and MEOX2 as important regulators …

Reviewing The Clostridioides Difficile Mouse Model: Insights Into Infection Mechanisms, José L Fachi, Marco A R Vinolo, Marco Colonna

2020-Current year OA Pubs

No abstract provided.

A Tale Of Two Viruses: Why Smallpox Was Eradicated And Polio Persists, Katherine G. Mcgough, Erin N. Bodine

Spora: A Journal of Biomathematics

The smallpox and poliomyelitis (polio) viruses were, at a time, one of the largest threats to global public health killing millions until global eradication campaigns were put into effect. Vaccination led to the eradication of smallpox and the elimination of polio for most of the world. However, polio continues to persist at endemic levels in Pakistan and Afghanistan. We developed ODE models of smallpox and polio to explore differences in transmission dynamics and determine if the underlying biology has made poliomyelitis more difficult to eradicate. Our model analysis shows there are multiple factors which should allow polio to have a …

Applications For Uncrewed Aircraft Systems At Night To Identify Hazardous Wildlife Species At Airport Environments, Janelle Drennan

Student Research Symposium (SRS)

Abstract

Wildlife strikes are a growing safety and economic concern for the US aviation industry. In this ongoing study, our team has explored the use of uncrewed aircraft systems (UAS) technologies by using thermal sensors to support data collection and analysis during simulated nighttime Wildlife Hazard Assessments (WHAs). Data has been collected between twilight and nightfall in a farmland area that is located approximately two nautical miles south of Daytona Beach International Airport. The research team has developed a Concept of Operations (CONOPs) to address safety risk management concepts and protocols to identify hazards and mitigate the associated risks with …

Investigation Into Cardiacmyhc-Α 334–352-Specific Tcr Transgenic Mice Reveals A Role For Cytotoxic Cd4 T Cells In The Development Of Cardiac Autoimmunity, Meghna Sur, Mahima T. Rasquinha, Kiruthiga Mone, Chandirasegaran Massilamany, Ninaad Lasrado, Channabasavaiah B. Gurumurthy, Raymond A. Sobel, Jay Reddy

Jay Reddy Publications

Myocarditis is one of the major causes of heart failure in children and young adults and can lead to dilated cardiomyopathy. Lymphocytic myocarditis could result from autoreactive CD4+ and CD8+ T cells, but defining antigen specificity in disease pathogenesis is challenging. To address this issue, we generated T cell receptor (TCR) transgenic (Tg) C57BL/6J mice specific to cardiac myosin heavy chain (Myhc)-α 334–352 and found that Myhc-α-specific TCRs were expressed in both CD4⁺ and CD8⁺ T cells. To investigate if the phenotype is more pronounced in a myocarditis-susceptible genetic background, we backcrossed with A/J mice. At the fourth …

Review Of Just Fodder: The Ethics Of Feeding Animals, Christopher A. Bobier

Between the Species

No abstract provided.

Emerging Roles Of Cullin-Ring Ubiquitin Ligases In Cardiac Development, Josue Zambrano-Carrasco, Jianqiu Zou, Wenjuan Wang, Xinghui Sun, Jie Li, Huabo Su

Department of Biochemistry: Faculty Publications

Heart development is a spatiotemporally regulated process that extends from the embryonic phase to postnatal stages. Disruption of this highly orchestrated process can lead to congenital heart disease or predispose the heart to cardiomyopathy or heart failure. Consequently, gaining an in-depth understanding of the molecular mechanisms governing cardiac development holds considerable promise for the development of innovative therapies for various cardiac ailments. While significant progress in uncovering novel transcriptional and epigenetic regulators of heart development has been made, the exploration of post-translational mechanisms that influence this process has lagged. Culling-RING E3 ubiquitin ligases (CRLs), the largest family of ubiquitin ligases, …

Non-Invasive Identification Of Vehicle Suspension Parameters: A Methodology Based On Synthetic Data Analysis, José Luis Olazagoitia, Alfonso De Hoyos Fernández De Córdova, Carlos Gijón-Rivera

Artículos científicos

In this study, we introduce an innovative approach for the identification of vehicle suspension parameters, employing a methodology that utilizes synthetic and experimental data for non-invasive analysis. Central to our approach is the application of a basic local optimization algorithm, chosen to establish a baseline for parameter identification in increasingly complex vehicle models, ranging from quarter-vehicle to half-vehicle (bicycle) models. This methodology enables the accurate simulation of the vehicle dynamics and the identification of suspension parameters under various conditions, including road perturbations such as speed bumps and curbs, as well as in the presence of noise. A significant aspect of …