Digital Commons Network^™

Reactive Amine Functionalized Microelectrode Arrays Provide Short-Term Benefit But Long-Term Detriment To In Vivo Recording Performance, Lindsey N. Druschel, Pierce E. Boucher, George F. Hoeferlin, Dhariyat M. Menendez, Jonathan L. Duncan, Jeffrey R. Capadona

Faculty Scholarship

Intracortical microelectrode arrays (MEAs) are used for recording neural signals. However, indwelling devices result in chronic neuroinflammation, which leads to decreased recording performance through degradation of the device and surrounding tissue. Coating the MEAs with bioactive molecules is being explored to mitigate neuroinflammation. Such approaches often require an intermediate functionalization step such as (3-aminopropyl)triethoxysilane (APTES), which serves as a linker. However, the standalone effect of this intermediate step has not been previously characterized. Here, we investigated the effect of coating MEAs with APTES by comparing APTES-coated to uncoated controls in vivo and ex vivo. First, we measured water contact angles …

Review Of Caenorhabditis Elegans In Food Nutritional Function Evaluation, Chen Wang, He Hailun, Zheng Yanjun, Yi Cuiping

Food and Machinery

As an ideal model organism, Caenorhabditis elegans has been increasingly used in the evaluation of the nutritional function of food. Compared with other models such as cells and mice, C. elegans have the advantages of small size, short lifespan, high genetic homology with humans, easy observation of research results, and large batch culture in the laboratory. Therefore, the article summarizes the research methods, potential mechanisms and research progress of C. elegans in food nutritional function such as anti-obesity, antioxidant and anti-aging. In order to provide a reference for new methods in the evaluation of food nutrition function.

Simulation Analysis Of The Influencing Parameters On The Shelling Efficiency Of Rubber Roller Husker Based On Adams, Wang Zixiao, Wang Wangping, Song Shaoyun

Food and Machinery

Objective: Improve the hulling efficiency of the rice huller. Methods: Simulated the process of rice hulling, and analyzed the influence of various parameters on the hulling process by changing the movement speed of the rubber roller and the line speed difference. Firstly, the model of huller and the model of single-sided shelled brown rice were established in SolidWorks, and then the established model was imported into ADAMS for simulation, and the effects of the corresponding factors on the hulling efficiency of huller were observed by changing the rotational speeds of the fast and slow rollers, the difference in line speeds …

Selective Neural Inhibition Via Photobiomodulation Alleviates Behavioral Hypersensitivity Associated With Small Sensory Fiber Activation, Andrew Buzza, Kalista Tapas, Junqi Zhuo, Stephen J. Lewis, Michael W. Jenkins, Michael Moffitt

Faculty Scholarship

Objective: Photobiomodulation at higher irradiances has great potential as a pain-alleviating method that selectively inhibits small diameter nerve fibers and corresponding sensory experiences, such as nociception and heat sensation. The longevity and magnitude of these effects as a function of laser irradiation parameters at the nerve was explored. Methods: In a rodent chronic pain model (spared nerve injury—SNI), light was applied directly at the sural nerve with four delivery schemes: two irradiance levels (7.64 and 2.55 W/cm2) for two durations each, corresponding to either 4.8 or 14.4 J total energy, and the effect on sensory hypersensitivities was evaluated. Results: At …

Development Of A Culinary Medicine Toolkit To Improve Implementation Of Virtual Cooking Classes For Low-Income Adults With Type 2 Diabetes, David Ai, Natalia I Heredia, Vanessa Cruz, Diana C Guevara, Shreela V Sharma, Dolores Woods, Melisa Danho, John Wesley Mcwhorter

Faculty, Staff and Student Publications

Culinary medicine (CM) addresses diseases through nutrition and culinary education. To promote access to educational material for people with diabetes and engagement in virtual classes, we created a virtual culinary medicine toolkit (VCMT) sensitive to literacy levels and language preferences. The VCMT was developed to accompany existing virtual CM programs and help improve participant interaction and retention, offering educational materials for providers and participants. The provider VCMT offers level-setting education to reduce mixed nutrition messaging, including educational resources discussing inclusive nutrition and mindful eating topics. Each handout has a QR code and link to engaging, animated videos that provide further …

Family-Based Early Intervention For Expressive Language Skills Of Children With Hearing Impairments, Qori A’Ina Azzahra, Endang Rochyadi, Sunardi Sunardi

Journal of ICSAR

The purpose of this study is early to formulate a hypothetical program of family-based early intervention that’s considered feasible and expected to be effective improving expressive language skills in children with hearing impairments. The study used a qualitative approach with family research subjects of deaf children aged 6 years who still have residual hearing and domiciled in Bandung. Data collection techniques are carried out through observation, interviews, and documentation studies. Based on the results of empirical analysis of abilities, obstacles, needs of children, and efforts that have been made by the family and its results, and based on the results …

The Integrated Sexual And Reproductive Health Learning Model For Children With Special Needs In West Java, East Java And North Sumatra Province, Ana Fatimatuzzahra, Endang Rochyadi, Riksma Nurhami Akhlan, Een Ratnengsih

Journal of ICSAR

The implementation of Sexual and Reproductive Health (SRH) Education in Special Schools is starting to get special attention. Having a Special Program designed for Children with Special Needs is an important factor that SRH’s material must be taught in Special Schools. However, in reality this Special Program is not comprehensive in delivering SRH’s material, so that it is widely spread in several other subjects such as Sciences, Religion, Character, Sports and Citizenship Education. The research aims to see the implementation of the SRH learning model in an integrated approach with those subjects that conducted by teachers in West Java, East …

The Effectiveness Of Learning Videos To Improve Elementary School Teachers' Understanding Of The Learning Characteristics Of Students With Special Needs, Ade Kartini, Imas Diana Aprilia, Endang Rochyadi

Journal of ICSAR

The lack of understanding of elementary school teachers about the learning characteristics of students with special needs and the lack of adaptive learning media is allegedly factors that do not optimize learning. This study aims to measure the effectiveness of learning videos in improving elementary school teachers' understanding of the learning characteristics of students with special needs. The research method used is descriptive quantitative with One Group Pre-test and Post-test design. Data collection was carried out through tests with research subjects, namely six teachers from two elementary schools in Sumedang Regency. The results of this study indicate an increase in …

[Review Of] Maria W. Stewart And The Roots Of Black Political Thought, By Kristin Waters, Jennifer Rycenga

Faculty Research, Scholarly, and Creative Activity

No abstract provided.

The Tone Poem: A Stolen Work, Michael Punt

School of Art, Design and Architecture

Medium: Image and text

Diversity In The Digital Age: How Consumers Respond To Diverse Virtual Influencers, Carla Ferraro, Sean Sands, Nives Zubcevic‐Basic, Colin L. Campbell

School of Business: Faculty Scholarship

In recent years the popularity of social media influencers has grown exponentially, in part because influencers tend to not be seen as advertising and they enable brands to reach engaged audiences. As such, influencer marketing is perceived as an effective and cost-effective marketing tool. However, like all areas of marketing there are broad-based shifts that are having significant effects on the domain of influencer marketing. First, there are calls for greater levels of diversity and broader representation of diverse communities. Second, digital innovation is having a profound effect on the field of influencer marketing, leading to the advent of virtual …

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

Myd88 In Myofibroblasts Enhances Nonalcoholic Fatty Liver Disease-Related Hepatocarcinogenesis Via Promoting Macrophage M2 Polarization, Yu Liu, Haiqiang Chen, Xuanxuan Yan, Jie Zhang, Zhenzhong Deng, Maosheng Huang, Jianchun Gu, Jinhua Zhang

Faculty, Staff and Student Publications

Background: Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver diseases and has emerged as the leading factor in the pathogenesis of hepatocellular carcinoma (HCC). MyD88 contributes to the development of HCC. However, the underlying mechanism by which MyD88 in myofibroblasts regulates NAFLD-associated liver cancer development remains unknown.

Results: Myofibroblast MyD88-deficient (SMAMyD88-/-) mice were protected from diet-induced obesity and developed fewer and smaller liver tumors. MyD88 deficiency in myofibroblasts attenuated macrophage M2 polarization and fat accumulation in HCC tissues. Mechanistically, MyD88 signaling in myofibroblasts enhanced CCL9 secretion, thereby promoting macrophage M2 polarization. This process may depend on …

A Cataract-Causing Mutation In The Trpm3 Cation Channel Disrupts Calcium Dynamics In The Lens, Yuefang Zhou, Thomas M Bennett, Philip A Ruzycki, Zhaohua Guo, Yu-Qing Cao, Mohammad Shahidullah, Nicholas A Delamere, Alan Shiels

2020-Current year OA Pubs

TRPM3 belongs to the melastatin sub-family of transient receptor potential (TRPM) cation channels and has been shown to function as a steroid-activated, heat-sensitive calcium ion (Ca

Hydrophobic Surface Patch Disruption To Produce Water-Soluble G-Protein Coupled Receptors, Christy Lynn Dyer

Electronic Theses and Dissertations Archive

G-Protein-Coupled Receptors (GPCR) are membrane protein receptors involved in most eukaryotic signaling processes. GPCR are the largest pharmaceutically relevant membrane protein group, serving as targets for approximately one-third of all drugs currently approved by the FDA and many drug candidates presently undergoing clinical trials. Still, only about one-fourth of all known GPCR are current pharmaceutical targets, leaving vast untapped potential. Chapter 1 describes the conserved structure of GPCR, and briefly introduces their diverse ligands and functions. The pharmaceutical relevance of GPCR is highlighted, along with some of the challenges associated with their structure determination that have hindered our understanding of …

Nest/Ing: An Emergent (Un)Methodology For Becoming Otherwise, Jayne Osgood, Claire Walsh

School of Law, Humanities and Social Sciences

A dense, pungent, brown-green, intricately woven, itchy-silky, moss-strewn, twig- ridden ball brought us together.Since then, nest(ing)[i] has become a shared methodology - nest/ing has offered a praxis of getting to know each other, getting to know nests (better) and it has become a capacious writing methodology. Taking nest(ing) seriously has drawn into sharp focus the perils of human exceptionalism. Nesting has gifted opportunities to wallow in porous boundaries and to luxuriate in modes of liminal reading/writing/experimenting, informed by a feminist politics to imagine the world differently (Despret, 2016). It is through lively storytelling, involving passing patterns back and forth that …

Enhancing Antibody Responses By Multivalent Antigen Display On Thymus-Independent Dna Origami Scaffolds, Eike-Christian Wamhoff, James Brett Case, Shilpa Sanapala, Michael S Diamond, Et Al.

2020-Current year OA Pubs

Protein-based virus-like particles (P-VLPs) are commonly used to spatially organize antigens and enhance humoral immunity through multivalent antigen display. However, P-VLPs are thymus-dependent antigens that are themselves immunogenic and can induce B cell responses that may neutralize the platform. Here, we investigate thymus-independent DNA origami as an alternative material for multivalent antigen display using the receptor binding domain (RBD) of the SARS-CoV-2 spike protein, the primary target of neutralizing antibody responses. Sequential immunization of mice with DNA-based VLPs (DNA-VLPs) elicits protective neutralizing antibodies to SARS-CoV-2 in a manner that depends on the valency of the antigen displayed and on T …

Expression Of Atoh1, Gfi1, And Pou4f3 In The Mature Cochlea Reprograms Nonsensory Cells Into Hair Cells, Melissa M Mcgovern, Ishwar V Hosamani, Yichi Niu, Ken Y Nguyen, Chenghang Zong, Andrew K Groves

Faculty, Staff and Students Publications

Mechanosensory hair cells of the mature mammalian organ of Corti do not regenerate; consequently, loss of hair cells leads to permanent hearing loss. Although nonmammalian vertebrates can regenerate hair cells from neighboring supporting cells, many humans with severe hearing loss lack both hair cells and supporting cells, with the organ of Corti being replaced by a flat epithelium of nonsensory cells. To determine whether the mature cochlea can produce hair cells in vivo, we reprogrammed nonsensory cells adjacent to the organ of Corti with three hair cell transcription factors: Gfi1, Atoh1, and Pou4f3. We generated numerous hair cell–like …

Hala Aswang!: A Zine On The Injustices During The Duterte Administration Foretold Through The Aswang Folklore, Eritch Angela Torrato

DLSU Senior High School Research Congress

The Duterte administration, which lasted from 2016 to 2022, incited a multitude of human rights violations against the marginalized groups of Philippine society, namely women, and the poor. It was discovered and established through literature that these injustices can primarily be attributed to the former president’s hypermasculinity, a manifestation of hegemonic masculinity in the contemporary era. Given this, this research then seeked to investigate the aforementioned phenomenon and communicate this using art, more specifically through the Aswang folklore and visual communication, to make these information accessible, especially to the masses; to foster social consciousness among its audience as a means …

Sales Of Cage-Free Eggs: The Impact Of Proposition 12 On Egg Prices And Consumer Welfare In California, Mingcong Xie

The Journal of Purdue Undergraduate Research

California’s Proposition 12, which outlaws the use of cages in the egg production process, went into effect on January 1, 2022. The main focus of this study is to follow the trend of weekly Californian and national egg price changes before and after the implementation of Proposition 12. Using the price series reported by the United States Department of Agriculture (USDA), structural break tests and Ordinary Least Squares (OLS) regressions are carried out to directly measure the economic impacts of this new regulation on egg prices. With different models used, this study shows that California consumers now pay an additional …

Machine Learning Of Big Data: A Gaussian Regression Model To Predict The Spatiotemporal Distribution Of Ground Ozone, Jerry Gu

The Journal of Purdue Undergraduate Research

Tracking pollution levels on the ground is important to the environment and public health. One of the pollutants of concern is ozone, which, at high concentrations, can cause respiratory and cardiovascular problems. The National Center for Atmospheric Research (NCAR) has published valuable ozone data obtained from ground-based sensors installed at selected locations. Because it is unfeasible to measure the exact ozone levels everywhere at any time, it would be valuable to predict the temporal-spatial distributions of ozone concentration based on existing data. This would help us better understand the patterns and trends in the data and make better decisions to …

Asking Jurors To Do The Impossible, Peter Tiersma

Tennessee Journal of Law and Policy

No abstract provided.

Racial Discrimination In The Death Penalty In Tennessee: An Empirical Assessment, John M. Scheb Ii, Kristin A. Wagers

Tennessee Journal of Law and Policy

No abstract provided.

Saving Biodiversity At The Crossroads Of The Americas, Colin Crawford

Tennessee Journal of Law and Policy

No abstract provided.

Interruptions And Intersections: Journeys To The Center Of The Americas, Francisco Valdes

Tennessee Journal of Law and Policy

No abstract provided.

The Utah Statesman, January 29, 2024, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

The Rider (2024-01-29), Natalie Lapsley

The Rider Archives

Vol.9 No.17

Week Of January 29, 2024, Student Life

College, School and Department Newsletters, Magazines, and Journals

Your weekly hub for events, resources and updates.

Patient-Derived Models Of Cancer In The Nci Pdmc Consortium: Selection, Pitfalls, And Practical Recommendations., Amber N Habowski, Deepthi P Budagavi, Sandra D Scherer, Arin B Aurora, Giuseppina Caligiuri, William F Flynn, Ellen M Langer, Jonathan R Brody, Rosalie C Sears, Giorgia Foggetti, Anna Arnal Estape, Don X Nguyen, Katerina A Politi, Xiling Shen, David S Hsu, Donna M Peehl, John Kurhanewicz, Renuka Sriram, Milagros Suarez, Sophie Xiao, Yuchen Du, Xiao-Nan Li, Nora M Navone, Estefania Labanca, Christopher D Willey

Faculty Research 2024

For over a century, early researchers sought to study biological organisms in a laboratory setting, leading to the generation of both in vitro and in vivo model systems. Patient-derived models of cancer (PDMCs) have more recently come to the forefront of preclinical cancer models and are even finding their way into clinical practice as part of functional precision medicine programs. The PDMC Consortium, supported by the Division of Cancer Biology in the National Cancer Institute of the National Institutes of Health, seeks to understand the biological principles that govern the various PDMC behaviors, particularly in response to perturbagens, such as …

Buah Buton In Traditional House Interior: Representation Of Women's Role And Influence, Fakhrur Razi Maamor, Sabzali Musa Kahn, Basitah Taif

Interiority

Buah buton is a three-dimensional wooden carving as an interior object in the traditional house of Negeri Sembilan. The purpose of this article is to establish a link between the buah buton in Luak Tanah Mengandung, Negeri Sembilan and the position of women who connect the legacy and leadership in the Adat Perpatih, a customary community law, and how such a relationship manifests itself within the traditional house's interior. The function of buah buton was revealed through fieldwork and interviews with community leaders, which were then combined into a narrative that represented the function of buah buton. The …